id sid tid token lemma pos en-wikipedia-org-9224 1 1 Immune immune JJ en-wikipedia-org-9224 1 2 system system NN en-wikipedia-org-9224 1 3 - - HYPH en-wikipedia-org-9224 1 4 Wikipedia wikipedia NN en-wikipedia-org-9224 1 5 Immune Immune NNP en-wikipedia-org-9224 1 6 system system NN en-wikipedia-org-9224 1 7 From from IN en-wikipedia-org-9224 1 8 Wikipedia Wikipedia NNP en-wikipedia-org-9224 1 9 , , , en-wikipedia-org-9224 1 10 the the DT en-wikipedia-org-9224 1 11 free free JJ en-wikipedia-org-9224 1 12 encyclopedia encyclopedia NN en-wikipedia-org-9224 1 13 Jump Jump NNP en-wikipedia-org-9224 1 14 to to IN en-wikipedia-org-9224 1 15 navigation navigation NN en-wikipedia-org-9224 1 16 Jump Jump NNP en-wikipedia-org-9224 1 17 to to TO en-wikipedia-org-9224 1 18 search search VB en-wikipedia-org-9224 1 19 A a DT en-wikipedia-org-9224 1 20 biological biological JJ en-wikipedia-org-9224 1 21 system system NN en-wikipedia-org-9224 1 22 that that WDT en-wikipedia-org-9224 1 23 protects protect VBZ en-wikipedia-org-9224 1 24 an an DT en-wikipedia-org-9224 1 25 organism organism NN en-wikipedia-org-9224 1 26 against against IN en-wikipedia-org-9224 1 27 disease disease NN en-wikipedia-org-9224 1 28 A a DT en-wikipedia-org-9224 1 29 scanning scan VBG en-wikipedia-org-9224 1 30 electron electron NN en-wikipedia-org-9224 1 31 microscope microscope NN en-wikipedia-org-9224 1 32 image image NN en-wikipedia-org-9224 1 33 of of IN en-wikipedia-org-9224 1 34 a a DT en-wikipedia-org-9224 1 35 single single JJ en-wikipedia-org-9224 1 36 white white JJ en-wikipedia-org-9224 1 37 blood blood NN en-wikipedia-org-9224 1 38 cell cell NN en-wikipedia-org-9224 1 39 ( ( -LRB- en-wikipedia-org-9224 1 40 yellow yellow NNP en-wikipedia-org-9224 1 41 / / SYM en-wikipedia-org-9224 1 42 right right JJ en-wikipedia-org-9224 1 43 ) ) -RRB- en-wikipedia-org-9224 1 44 , , , en-wikipedia-org-9224 1 45 engulfing engulf VBG en-wikipedia-org-9224 1 46 anthrax anthrax NN en-wikipedia-org-9224 1 47 bacteria bacteria NNS en-wikipedia-org-9224 1 48 ( ( -LRB- en-wikipedia-org-9224 1 49 orange orange NNP en-wikipedia-org-9224 1 50 / / SYM en-wikipedia-org-9224 1 51 left left JJ en-wikipedia-org-9224 1 52 ) ) -RRB- en-wikipedia-org-9224 1 53 – – : en-wikipedia-org-9224 1 54 scale scale NN en-wikipedia-org-9224 1 55 bar bar NN en-wikipedia-org-9224 1 56 is be VBZ en-wikipedia-org-9224 1 57 5 5 CD en-wikipedia-org-9224 1 58 µm µm NNP en-wikipedia-org-9224 1 59 ( ( -LRB- en-wikipedia-org-9224 1 60 false false JJ en-wikipedia-org-9224 1 61 color color NN en-wikipedia-org-9224 1 62 ) ) -RRB- en-wikipedia-org-9224 1 63 The the DT en-wikipedia-org-9224 1 64 immune immune JJ en-wikipedia-org-9224 1 65 system system NN en-wikipedia-org-9224 1 66 is be VBZ en-wikipedia-org-9224 1 67 a a DT en-wikipedia-org-9224 1 68 network network NN en-wikipedia-org-9224 1 69 of of IN en-wikipedia-org-9224 1 70 biological biological JJ en-wikipedia-org-9224 1 71 processes process NNS en-wikipedia-org-9224 1 72 that that WDT en-wikipedia-org-9224 1 73 protects protect VBZ en-wikipedia-org-9224 1 74 an an DT en-wikipedia-org-9224 1 75 organism organism NN en-wikipedia-org-9224 1 76 against against IN en-wikipedia-org-9224 1 77 disease disease NN en-wikipedia-org-9224 1 78 . . . en-wikipedia-org-9224 2 1 It -PRON- PRP en-wikipedia-org-9224 2 2 detects detect VBZ en-wikipedia-org-9224 2 3 and and CC en-wikipedia-org-9224 2 4 responds respond VBZ en-wikipedia-org-9224 2 5 to to IN en-wikipedia-org-9224 2 6 a a DT en-wikipedia-org-9224 2 7 wide wide JJ en-wikipedia-org-9224 2 8 variety variety NN en-wikipedia-org-9224 2 9 of of IN en-wikipedia-org-9224 2 10 pathogens pathogen NNS en-wikipedia-org-9224 2 11 , , , en-wikipedia-org-9224 2 12 from from IN en-wikipedia-org-9224 2 13 viruses virus NNS en-wikipedia-org-9224 2 14 to to IN en-wikipedia-org-9224 2 15 parasitic parasitic JJ en-wikipedia-org-9224 2 16 worms worm NNS en-wikipedia-org-9224 2 17 , , , en-wikipedia-org-9224 2 18 as as RB en-wikipedia-org-9224 2 19 well well RB en-wikipedia-org-9224 2 20 as as IN en-wikipedia-org-9224 2 21 cancer cancer NN en-wikipedia-org-9224 2 22 cells cell NNS en-wikipedia-org-9224 2 23 and and CC en-wikipedia-org-9224 2 24 objects object NNS en-wikipedia-org-9224 2 25 such such JJ en-wikipedia-org-9224 2 26 as as IN en-wikipedia-org-9224 2 27 wood wood NN en-wikipedia-org-9224 2 28 splinters splinter NNS en-wikipedia-org-9224 2 29 , , , en-wikipedia-org-9224 2 30 distinguishing distinguish VBG en-wikipedia-org-9224 2 31 them -PRON- PRP en-wikipedia-org-9224 2 32 from from IN en-wikipedia-org-9224 2 33 the the DT en-wikipedia-org-9224 2 34 organism organism NN en-wikipedia-org-9224 2 35 's 's POS en-wikipedia-org-9224 2 36 own own JJ en-wikipedia-org-9224 2 37 healthy healthy JJ en-wikipedia-org-9224 2 38 tissue tissue NN en-wikipedia-org-9224 2 39 . . . en-wikipedia-org-9224 3 1 Many many JJ en-wikipedia-org-9224 3 2 species specie NNS en-wikipedia-org-9224 3 3 have have VBP en-wikipedia-org-9224 3 4 two two CD en-wikipedia-org-9224 3 5 major major JJ en-wikipedia-org-9224 3 6 subsystems subsystem NNS en-wikipedia-org-9224 3 7 of of IN en-wikipedia-org-9224 3 8 the the DT en-wikipedia-org-9224 3 9 immune immune JJ en-wikipedia-org-9224 3 10 system system NN en-wikipedia-org-9224 3 11 . . . en-wikipedia-org-9224 4 1 The the DT en-wikipedia-org-9224 4 2 innate innate JJ en-wikipedia-org-9224 4 3 immune immune JJ en-wikipedia-org-9224 4 4 system system NN en-wikipedia-org-9224 4 5 provides provide VBZ en-wikipedia-org-9224 4 6 a a DT en-wikipedia-org-9224 4 7 preconfigured preconfigure VBN en-wikipedia-org-9224 4 8 response response NN en-wikipedia-org-9224 4 9 to to IN en-wikipedia-org-9224 4 10 broad broad JJ en-wikipedia-org-9224 4 11 groups group NNS en-wikipedia-org-9224 4 12 of of IN en-wikipedia-org-9224 4 13 situations situation NNS en-wikipedia-org-9224 4 14 and and CC en-wikipedia-org-9224 4 15 stimuli stimulus NNS en-wikipedia-org-9224 4 16 . . . en-wikipedia-org-9224 5 1 The the DT en-wikipedia-org-9224 5 2 adaptive adaptive JJ en-wikipedia-org-9224 5 3 immune immune JJ en-wikipedia-org-9224 5 4 system system NN en-wikipedia-org-9224 5 5 provides provide VBZ en-wikipedia-org-9224 5 6 a a DT en-wikipedia-org-9224 5 7 tailored tailor VBN en-wikipedia-org-9224 5 8 response response NN en-wikipedia-org-9224 5 9 to to IN en-wikipedia-org-9224 5 10 each each DT en-wikipedia-org-9224 5 11 stimulus stimulus NN en-wikipedia-org-9224 5 12 by by IN en-wikipedia-org-9224 5 13 learning learn VBG en-wikipedia-org-9224 5 14 to to TO en-wikipedia-org-9224 5 15 recognize recognize VB en-wikipedia-org-9224 5 16 molecules molecule NNS en-wikipedia-org-9224 5 17 it -PRON- PRP en-wikipedia-org-9224 5 18 has have VBZ en-wikipedia-org-9224 5 19 previously previously RB en-wikipedia-org-9224 5 20 encountered encounter VBN en-wikipedia-org-9224 5 21 . . . en-wikipedia-org-9224 6 1 Both both DT en-wikipedia-org-9224 6 2 use use VBP en-wikipedia-org-9224 6 3 molecules molecule NNS en-wikipedia-org-9224 6 4 and and CC en-wikipedia-org-9224 6 5 cells cell NNS en-wikipedia-org-9224 6 6 to to TO en-wikipedia-org-9224 6 7 perform perform VB en-wikipedia-org-9224 6 8 their -PRON- PRP$ en-wikipedia-org-9224 6 9 functions function NNS en-wikipedia-org-9224 6 10 . . . en-wikipedia-org-9224 7 1 Nearly nearly RB en-wikipedia-org-9224 7 2 all all DT en-wikipedia-org-9224 7 3 organisms organism NNS en-wikipedia-org-9224 7 4 have have VBP en-wikipedia-org-9224 7 5 some some DT en-wikipedia-org-9224 7 6 kind kind NN en-wikipedia-org-9224 7 7 of of IN en-wikipedia-org-9224 7 8 immune immune JJ en-wikipedia-org-9224 7 9 system system NN en-wikipedia-org-9224 7 10 . . . en-wikipedia-org-9224 8 1 Bacteria Bacteria NNS en-wikipedia-org-9224 8 2 have have VBP en-wikipedia-org-9224 8 3 a a DT en-wikipedia-org-9224 8 4 rudimentary rudimentary JJ en-wikipedia-org-9224 8 5 immune immune JJ en-wikipedia-org-9224 8 6 system system NN en-wikipedia-org-9224 8 7 in in IN en-wikipedia-org-9224 8 8 the the DT en-wikipedia-org-9224 8 9 form form NN en-wikipedia-org-9224 8 10 of of IN en-wikipedia-org-9224 8 11 enzymes enzyme NNS en-wikipedia-org-9224 8 12 that that WDT en-wikipedia-org-9224 8 13 protect protect VBP en-wikipedia-org-9224 8 14 against against IN en-wikipedia-org-9224 8 15 virus virus NN en-wikipedia-org-9224 8 16 infections infection NNS en-wikipedia-org-9224 8 17 . . . en-wikipedia-org-9224 9 1 Other other JJ en-wikipedia-org-9224 9 2 basic basic JJ en-wikipedia-org-9224 9 3 immune immune JJ en-wikipedia-org-9224 9 4 mechanisms mechanism NNS en-wikipedia-org-9224 9 5 evolved evolve VBN en-wikipedia-org-9224 9 6 in in IN en-wikipedia-org-9224 9 7 ancient ancient JJ en-wikipedia-org-9224 9 8 plants plant NNS en-wikipedia-org-9224 9 9 and and CC en-wikipedia-org-9224 9 10 animals animal NNS en-wikipedia-org-9224 9 11 and and CC en-wikipedia-org-9224 9 12 remain remain VBP en-wikipedia-org-9224 9 13 in in IN en-wikipedia-org-9224 9 14 their -PRON- PRP$ en-wikipedia-org-9224 9 15 modern modern JJ en-wikipedia-org-9224 9 16 descendants descendant NNS en-wikipedia-org-9224 9 17 . . . en-wikipedia-org-9224 10 1 These these DT en-wikipedia-org-9224 10 2 mechanisms mechanism NNS en-wikipedia-org-9224 10 3 include include VBP en-wikipedia-org-9224 10 4 phagocytosis phagocytosis NN en-wikipedia-org-9224 10 5 , , , en-wikipedia-org-9224 10 6 antimicrobial antimicrobial JJ en-wikipedia-org-9224 10 7 peptides peptide NNS en-wikipedia-org-9224 10 8 called call VBD en-wikipedia-org-9224 10 9 defensins defensin NNS en-wikipedia-org-9224 10 10 , , , en-wikipedia-org-9224 10 11 and and CC en-wikipedia-org-9224 10 12 the the DT en-wikipedia-org-9224 10 13 complement complement NN en-wikipedia-org-9224 10 14 system system NN en-wikipedia-org-9224 10 15 . . . en-wikipedia-org-9224 11 1 Jawed jawed JJ en-wikipedia-org-9224 11 2 vertebrates vertebrate NNS en-wikipedia-org-9224 11 3 , , , en-wikipedia-org-9224 11 4 including include VBG en-wikipedia-org-9224 11 5 humans human NNS en-wikipedia-org-9224 11 6 , , , en-wikipedia-org-9224 11 7 have have VBP en-wikipedia-org-9224 11 8 even even RB en-wikipedia-org-9224 11 9 more more RBR en-wikipedia-org-9224 11 10 sophisticated sophisticated JJ en-wikipedia-org-9224 11 11 defense defense NN en-wikipedia-org-9224 11 12 mechanisms mechanism NNS en-wikipedia-org-9224 11 13 , , , en-wikipedia-org-9224 11 14 including include VBG en-wikipedia-org-9224 11 15 the the DT en-wikipedia-org-9224 11 16 ability ability NN en-wikipedia-org-9224 11 17 to to TO en-wikipedia-org-9224 11 18 adapt adapt VB en-wikipedia-org-9224 11 19 to to TO en-wikipedia-org-9224 11 20 recognize recognize VB en-wikipedia-org-9224 11 21 pathogens pathogen NNS en-wikipedia-org-9224 11 22 more more RBR en-wikipedia-org-9224 11 23 efficiently efficiently RB en-wikipedia-org-9224 11 24 . . . en-wikipedia-org-9224 12 1 Adaptive adaptive JJ en-wikipedia-org-9224 12 2 ( ( -LRB- en-wikipedia-org-9224 12 3 or or CC en-wikipedia-org-9224 12 4 acquired acquire VBN en-wikipedia-org-9224 12 5 ) ) -RRB- en-wikipedia-org-9224 12 6 immunity immunity NN en-wikipedia-org-9224 12 7 creates create VBZ en-wikipedia-org-9224 12 8 an an DT en-wikipedia-org-9224 12 9 immunological immunological JJ en-wikipedia-org-9224 12 10 memory memory NN en-wikipedia-org-9224 12 11 leading lead VBG en-wikipedia-org-9224 12 12 to to IN en-wikipedia-org-9224 12 13 an an DT en-wikipedia-org-9224 12 14 enhanced enhanced JJ en-wikipedia-org-9224 12 15 response response NN en-wikipedia-org-9224 12 16 to to IN en-wikipedia-org-9224 12 17 subsequent subsequent JJ en-wikipedia-org-9224 12 18 encounters encounter NNS en-wikipedia-org-9224 12 19 with with IN en-wikipedia-org-9224 12 20 that that DT en-wikipedia-org-9224 12 21 same same JJ en-wikipedia-org-9224 12 22 pathogen pathogen NN en-wikipedia-org-9224 12 23 . . . en-wikipedia-org-9224 13 1 This this DT en-wikipedia-org-9224 13 2 process process NN en-wikipedia-org-9224 13 3 of of IN en-wikipedia-org-9224 13 4 acquired acquire VBN en-wikipedia-org-9224 13 5 immunity immunity NN en-wikipedia-org-9224 13 6 is be VBZ en-wikipedia-org-9224 13 7 the the DT en-wikipedia-org-9224 13 8 basis basis NN en-wikipedia-org-9224 13 9 of of IN en-wikipedia-org-9224 13 10 vaccination vaccination NN en-wikipedia-org-9224 13 11 . . . en-wikipedia-org-9224 14 1 Dysfunction dysfunction NN en-wikipedia-org-9224 14 2 of of IN en-wikipedia-org-9224 14 3 the the DT en-wikipedia-org-9224 14 4 immune immune JJ en-wikipedia-org-9224 14 5 system system NN en-wikipedia-org-9224 14 6 can can MD en-wikipedia-org-9224 14 7 cause cause VB en-wikipedia-org-9224 14 8 autoimmune autoimmune JJ en-wikipedia-org-9224 14 9 diseases disease NNS en-wikipedia-org-9224 14 10 , , , en-wikipedia-org-9224 14 11 inflammatory inflammatory JJ en-wikipedia-org-9224 14 12 diseases disease NNS en-wikipedia-org-9224 14 13 and and CC en-wikipedia-org-9224 14 14 cancer cancer NN en-wikipedia-org-9224 14 15 . . . en-wikipedia-org-9224 15 1 Immunodeficiency immunodeficiency NN en-wikipedia-org-9224 15 2 occurs occur VBZ en-wikipedia-org-9224 15 3 when when WRB en-wikipedia-org-9224 15 4 the the DT en-wikipedia-org-9224 15 5 immune immune JJ en-wikipedia-org-9224 15 6 system system NN en-wikipedia-org-9224 15 7 is be VBZ en-wikipedia-org-9224 15 8 less less RBR en-wikipedia-org-9224 15 9 active active JJ en-wikipedia-org-9224 15 10 than than IN en-wikipedia-org-9224 15 11 normal normal JJ en-wikipedia-org-9224 15 12 , , , en-wikipedia-org-9224 15 13 resulting result VBG en-wikipedia-org-9224 15 14 in in IN en-wikipedia-org-9224 15 15 recurring recurring NN en-wikipedia-org-9224 15 16 and and CC en-wikipedia-org-9224 15 17 life life NN en-wikipedia-org-9224 15 18 - - HYPH en-wikipedia-org-9224 15 19 threatening threaten VBG en-wikipedia-org-9224 15 20 infections infection NNS en-wikipedia-org-9224 15 21 . . . en-wikipedia-org-9224 16 1 In in IN en-wikipedia-org-9224 16 2 humans human NNS en-wikipedia-org-9224 16 3 , , , en-wikipedia-org-9224 16 4 immunodeficiency immunodeficiency NN en-wikipedia-org-9224 16 5 can can MD en-wikipedia-org-9224 16 6 be be VB en-wikipedia-org-9224 16 7 the the DT en-wikipedia-org-9224 16 8 result result NN en-wikipedia-org-9224 16 9 of of IN en-wikipedia-org-9224 16 10 a a DT en-wikipedia-org-9224 16 11 genetic genetic JJ en-wikipedia-org-9224 16 12 disease disease NN en-wikipedia-org-9224 16 13 such such JJ en-wikipedia-org-9224 16 14 as as IN en-wikipedia-org-9224 16 15 severe severe JJ en-wikipedia-org-9224 16 16 combined combine VBN en-wikipedia-org-9224 16 17 immunodeficiency immunodeficiency NN en-wikipedia-org-9224 16 18 , , , en-wikipedia-org-9224 16 19 acquired acquire VBD en-wikipedia-org-9224 16 20 conditions condition NNS en-wikipedia-org-9224 16 21 such such JJ en-wikipedia-org-9224 16 22 as as IN en-wikipedia-org-9224 16 23 HIV HIV NNP en-wikipedia-org-9224 16 24 / / SYM en-wikipedia-org-9224 16 25 AIDS AIDS NNP en-wikipedia-org-9224 16 26 , , , en-wikipedia-org-9224 16 27 or or CC en-wikipedia-org-9224 16 28 the the DT en-wikipedia-org-9224 16 29 use use NN en-wikipedia-org-9224 16 30 of of IN en-wikipedia-org-9224 16 31 immunosuppressive immunosuppressive JJ en-wikipedia-org-9224 16 32 medication medication NN en-wikipedia-org-9224 16 33 . . . en-wikipedia-org-9224 17 1 Autoimmunity autoimmunity NN en-wikipedia-org-9224 17 2 results result VBZ en-wikipedia-org-9224 17 3 from from IN en-wikipedia-org-9224 17 4 a a DT en-wikipedia-org-9224 17 5 hyperactive hyperactive JJ en-wikipedia-org-9224 17 6 immune immune JJ en-wikipedia-org-9224 17 7 system system NN en-wikipedia-org-9224 17 8 attacking attack VBG en-wikipedia-org-9224 17 9 normal normal JJ en-wikipedia-org-9224 17 10 tissues tissue NNS en-wikipedia-org-9224 17 11 as as IN en-wikipedia-org-9224 17 12 if if IN en-wikipedia-org-9224 17 13 they -PRON- PRP en-wikipedia-org-9224 17 14 were be VBD en-wikipedia-org-9224 17 15 foreign foreign JJ en-wikipedia-org-9224 17 16 organisms organism NNS en-wikipedia-org-9224 17 17 . . . en-wikipedia-org-9224 18 1 Common common JJ en-wikipedia-org-9224 18 2 autoimmune autoimmune JJ en-wikipedia-org-9224 18 3 diseases disease NNS en-wikipedia-org-9224 18 4 include include VBP en-wikipedia-org-9224 18 5 Hashimoto Hashimoto NNP en-wikipedia-org-9224 18 6 's 's POS en-wikipedia-org-9224 18 7 thyroiditis thyroiditis NN en-wikipedia-org-9224 18 8 , , , en-wikipedia-org-9224 18 9 rheumatoid rheumatoid JJ en-wikipedia-org-9224 18 10 arthritis arthritis NNP en-wikipedia-org-9224 18 11 , , , en-wikipedia-org-9224 18 12 diabetes diabete VBZ en-wikipedia-org-9224 18 13 mellitus mellitus NN en-wikipedia-org-9224 18 14 type type NN en-wikipedia-org-9224 18 15 1 1 CD en-wikipedia-org-9224 18 16 , , , en-wikipedia-org-9224 18 17 and and CC en-wikipedia-org-9224 18 18 systemic systemic JJ en-wikipedia-org-9224 18 19 lupus lupus NNP en-wikipedia-org-9224 18 20 erythematosus erythematosus NNP en-wikipedia-org-9224 18 21 . . . en-wikipedia-org-9224 19 1 Immunology immunology NN en-wikipedia-org-9224 19 2 covers cover VBZ en-wikipedia-org-9224 19 3 the the DT en-wikipedia-org-9224 19 4 study study NN en-wikipedia-org-9224 19 5 of of IN en-wikipedia-org-9224 19 6 all all DT en-wikipedia-org-9224 19 7 aspects aspect NNS en-wikipedia-org-9224 19 8 of of IN en-wikipedia-org-9224 19 9 the the DT en-wikipedia-org-9224 19 10 immune immune JJ en-wikipedia-org-9224 19 11 system system NN en-wikipedia-org-9224 19 12 . . . en-wikipedia-org-9224 20 1 Contents content NNS en-wikipedia-org-9224 20 2 1 1 CD en-wikipedia-org-9224 20 3 Layered layered JJ en-wikipedia-org-9224 20 4 defense defense NN en-wikipedia-org-9224 20 5 2 2 CD en-wikipedia-org-9224 20 6 Surface Surface NNP en-wikipedia-org-9224 20 7 barriers barrier NNS en-wikipedia-org-9224 20 8 3 3 CD en-wikipedia-org-9224 20 9 Innate innate VBP en-wikipedia-org-9224 20 10 immune immune JJ en-wikipedia-org-9224 20 11 system system NN en-wikipedia-org-9224 20 12 3.1 3.1 CD en-wikipedia-org-9224 20 13 Immune immune JJ en-wikipedia-org-9224 20 14 sensing sense VBG en-wikipedia-org-9224 20 15 3.2 3.2 CD en-wikipedia-org-9224 20 16 Innate innate VBP en-wikipedia-org-9224 20 17 immune immune JJ en-wikipedia-org-9224 20 18 cells cell NNS en-wikipedia-org-9224 20 19 3.3 3.3 CD en-wikipedia-org-9224 20 20 Inflammation inflammation NN en-wikipedia-org-9224 20 21 3.4 3.4 CD en-wikipedia-org-9224 20 22 Humoral Humoral NNP en-wikipedia-org-9224 20 23 defenses defense VBZ en-wikipedia-org-9224 20 24 4 4 CD en-wikipedia-org-9224 20 25 Adaptive adaptive JJ en-wikipedia-org-9224 20 26 immune immune JJ en-wikipedia-org-9224 20 27 system system NN en-wikipedia-org-9224 20 28 4.1 4.1 CD en-wikipedia-org-9224 20 29 Recognition Recognition NNP en-wikipedia-org-9224 20 30 of of IN en-wikipedia-org-9224 20 31 antigen antigen NNP en-wikipedia-org-9224 20 32 4.2 4.2 CD en-wikipedia-org-9224 20 33 Antigen Antigen NNP en-wikipedia-org-9224 20 34 presentation presentation NN en-wikipedia-org-9224 20 35 to to IN en-wikipedia-org-9224 20 36 T t NN en-wikipedia-org-9224 20 37 lymphocytes lymphocyte VBZ en-wikipedia-org-9224 20 38 4.3 4.3 CD en-wikipedia-org-9224 20 39 Cell cell NN en-wikipedia-org-9224 20 40 mediated mediate VBN en-wikipedia-org-9224 20 41 immunity immunity NN en-wikipedia-org-9224 20 42 4.3.1 4.3.1 CD en-wikipedia-org-9224 20 43 Killer Killer NNP en-wikipedia-org-9224 20 44 T T NNP en-wikipedia-org-9224 20 45 cells cell NNS en-wikipedia-org-9224 20 46 4.3.2 4.3.2 CD en-wikipedia-org-9224 20 47 Helper helper NN en-wikipedia-org-9224 20 48 T T NNP en-wikipedia-org-9224 20 49 cells cell NNS en-wikipedia-org-9224 20 50 4.3.3 4.3.3 NNP en-wikipedia-org-9224 20 51 Gamma Gamma NNP en-wikipedia-org-9224 20 52 delta delta NN en-wikipedia-org-9224 20 53 T T NNP en-wikipedia-org-9224 20 54 cells cell VBZ en-wikipedia-org-9224 20 55 4.4 4.4 CD en-wikipedia-org-9224 20 56 Humoral humoral JJ en-wikipedia-org-9224 20 57 immune immune JJ en-wikipedia-org-9224 20 58 response response NN en-wikipedia-org-9224 20 59 4.5 4.5 CD en-wikipedia-org-9224 20 60 Immunological immunological JJ en-wikipedia-org-9224 20 61 memory memory NN en-wikipedia-org-9224 20 62 5 5 CD en-wikipedia-org-9224 20 63 Physiological physiological JJ en-wikipedia-org-9224 20 64 regulation regulation NN en-wikipedia-org-9224 20 65 5.1 5.1 CD en-wikipedia-org-9224 20 66 Hormones Hormones NNPS en-wikipedia-org-9224 20 67 5.2 5.2 CD en-wikipedia-org-9224 20 68 Vitamin vitamin NN en-wikipedia-org-9224 20 69 D d NN en-wikipedia-org-9224 20 70 5.3 5.3 CD en-wikipedia-org-9224 20 71 Sleep Sleep NNP en-wikipedia-org-9224 20 72 and and CC en-wikipedia-org-9224 20 73 rest rest VB en-wikipedia-org-9224 20 74 5.4 5.4 CD en-wikipedia-org-9224 20 75 Nutrition nutrition NN en-wikipedia-org-9224 20 76 and and CC en-wikipedia-org-9224 20 77 diet diet NN en-wikipedia-org-9224 20 78 5.5 5.5 CD en-wikipedia-org-9224 20 79 Repair repair NN en-wikipedia-org-9224 20 80 and and CC en-wikipedia-org-9224 20 81 regeneration regeneration NN en-wikipedia-org-9224 20 82 6 6 CD en-wikipedia-org-9224 20 83 Disorders Disorders NNPS en-wikipedia-org-9224 20 84 of of IN en-wikipedia-org-9224 20 85 human human JJ en-wikipedia-org-9224 20 86 immunity immunity NN en-wikipedia-org-9224 20 87 6.1 6.1 CD en-wikipedia-org-9224 20 88 Immunodeficiencies Immunodeficiencies NNPS en-wikipedia-org-9224 20 89 6.2 6.2 CD en-wikipedia-org-9224 20 90 Autoimmunity autoimmunity NN en-wikipedia-org-9224 20 91 6.3 6.3 CD en-wikipedia-org-9224 20 92 Hypersensitivity Hypersensitivity NNP en-wikipedia-org-9224 20 93 6.4 6.4 CD en-wikipedia-org-9224 20 94 Idiopathic idiopathic JJ en-wikipedia-org-9224 20 95 inflammation inflammation NN en-wikipedia-org-9224 20 96 7 7 CD en-wikipedia-org-9224 20 97 Manipulation manipulation NN en-wikipedia-org-9224 20 98 in in IN en-wikipedia-org-9224 20 99 medicine medicine NN en-wikipedia-org-9224 20 100 7.1 7.1 CD en-wikipedia-org-9224 20 101 Immunosuppression Immunosuppression NNP en-wikipedia-org-9224 20 102 7.2 7.2 CD en-wikipedia-org-9224 20 103 Immunostimulation Immunostimulation NNP en-wikipedia-org-9224 20 104 7.3 7.3 CD en-wikipedia-org-9224 20 105 Vaccination vaccination NN en-wikipedia-org-9224 20 106 7.4 7.4 CD en-wikipedia-org-9224 20 107 Tumor Tumor NNP en-wikipedia-org-9224 20 108 immunology immunology NN en-wikipedia-org-9224 20 109 7.5 7.5 CD en-wikipedia-org-9224 20 110 Predicting Predicting NNP en-wikipedia-org-9224 20 111 immunogenicity immunogenicity NN en-wikipedia-org-9224 20 112 8 8 CD en-wikipedia-org-9224 20 113 Evolution evolution NN en-wikipedia-org-9224 20 114 and and CC en-wikipedia-org-9224 20 115 other other JJ en-wikipedia-org-9224 20 116 mechanisms mechanism NNS en-wikipedia-org-9224 20 117 8.1 8.1 CD en-wikipedia-org-9224 20 118 Evolution Evolution NNP en-wikipedia-org-9224 20 119 of of IN en-wikipedia-org-9224 20 120 the the DT en-wikipedia-org-9224 20 121 immune immune JJ en-wikipedia-org-9224 20 122 system system NN en-wikipedia-org-9224 20 123 8.2 8.2 CD en-wikipedia-org-9224 20 124 Alternative alternative JJ en-wikipedia-org-9224 20 125 adaptive adaptive JJ en-wikipedia-org-9224 20 126 immune immune JJ en-wikipedia-org-9224 20 127 system system NN en-wikipedia-org-9224 20 128 8.3 8.3 CD en-wikipedia-org-9224 20 129 Manipulation Manipulation NNP en-wikipedia-org-9224 20 130 by by IN en-wikipedia-org-9224 20 131 pathogens pathogen NNS en-wikipedia-org-9224 20 132 9 9 CD en-wikipedia-org-9224 20 133 History history NN en-wikipedia-org-9224 20 134 of of IN en-wikipedia-org-9224 20 135 immunology immunology NN en-wikipedia-org-9224 20 136 10 10 CD en-wikipedia-org-9224 20 137 See see VB en-wikipedia-org-9224 20 138 also also RB en-wikipedia-org-9224 20 139 11 11 CD en-wikipedia-org-9224 20 140 References reference NNS en-wikipedia-org-9224 20 141 11.1 11.1 CD en-wikipedia-org-9224 20 142 Bibliography Bibliography NNP en-wikipedia-org-9224 20 143 12 12 CD en-wikipedia-org-9224 20 144 External external JJ en-wikipedia-org-9224 20 145 links link NNS en-wikipedia-org-9224 20 146 Layered layer VBD en-wikipedia-org-9224 20 147 defense[edit defense[edit LS en-wikipedia-org-9224 20 148 ] ] -RRB- en-wikipedia-org-9224 20 149 The the DT en-wikipedia-org-9224 20 150 immune immune JJ en-wikipedia-org-9224 20 151 system system NN en-wikipedia-org-9224 20 152 protects protect VBZ en-wikipedia-org-9224 20 153 its -PRON- PRP$ en-wikipedia-org-9224 20 154 host host NN en-wikipedia-org-9224 20 155 from from IN en-wikipedia-org-9224 20 156 infection infection NN en-wikipedia-org-9224 20 157 with with IN en-wikipedia-org-9224 20 158 layered layered JJ en-wikipedia-org-9224 20 159 defenses defense NNS en-wikipedia-org-9224 20 160 of of IN en-wikipedia-org-9224 20 161 increasing increase VBG en-wikipedia-org-9224 20 162 specificity specificity NN en-wikipedia-org-9224 20 163 . . . en-wikipedia-org-9224 21 1 Physical physical JJ en-wikipedia-org-9224 21 2 barriers barrier NNS en-wikipedia-org-9224 21 3 prevent prevent VBP en-wikipedia-org-9224 21 4 pathogens pathogen NNS en-wikipedia-org-9224 21 5 such such JJ en-wikipedia-org-9224 21 6 as as IN en-wikipedia-org-9224 21 7 bacteria bacteria NNS en-wikipedia-org-9224 21 8 and and CC en-wikipedia-org-9224 21 9 viruses virus NNS en-wikipedia-org-9224 21 10 from from IN en-wikipedia-org-9224 21 11 entering enter VBG en-wikipedia-org-9224 21 12 the the DT en-wikipedia-org-9224 21 13 organism organism NN en-wikipedia-org-9224 21 14 . . . en-wikipedia-org-9224 22 1 [ [ -LRB- en-wikipedia-org-9224 22 2 1 1 LS en-wikipedia-org-9224 22 3 ] ] -RRB- en-wikipedia-org-9224 22 4 If if IN en-wikipedia-org-9224 22 5 a a DT en-wikipedia-org-9224 22 6 pathogen pathogen NN en-wikipedia-org-9224 22 7 breaches breach VBZ en-wikipedia-org-9224 22 8 these these DT en-wikipedia-org-9224 22 9 barriers barrier NNS en-wikipedia-org-9224 22 10 , , , en-wikipedia-org-9224 22 11 the the DT en-wikipedia-org-9224 22 12 innate innate JJ en-wikipedia-org-9224 22 13 immune immune JJ en-wikipedia-org-9224 22 14 system system NN en-wikipedia-org-9224 22 15 provides provide VBZ en-wikipedia-org-9224 22 16 an an DT en-wikipedia-org-9224 22 17 immediate immediate JJ en-wikipedia-org-9224 22 18 , , , en-wikipedia-org-9224 22 19 but but CC en-wikipedia-org-9224 22 20 non non JJ en-wikipedia-org-9224 22 21 - - JJ en-wikipedia-org-9224 22 22 specific specific JJ en-wikipedia-org-9224 22 23 response response NN en-wikipedia-org-9224 22 24 . . . en-wikipedia-org-9224 23 1 Innate innate VB en-wikipedia-org-9224 23 2 immune immune JJ en-wikipedia-org-9224 23 3 systems system NNS en-wikipedia-org-9224 23 4 are be VBP en-wikipedia-org-9224 23 5 found find VBN en-wikipedia-org-9224 23 6 in in IN en-wikipedia-org-9224 23 7 all all DT en-wikipedia-org-9224 23 8 animals animal NNS en-wikipedia-org-9224 23 9 . . . en-wikipedia-org-9224 24 1 [ [ -LRB- en-wikipedia-org-9224 24 2 2 2 LS en-wikipedia-org-9224 24 3 ] ] -RRB- en-wikipedia-org-9224 24 4 If if IN en-wikipedia-org-9224 24 5 pathogens pathogen NNS en-wikipedia-org-9224 24 6 successfully successfully RB en-wikipedia-org-9224 24 7 evade evade VBP en-wikipedia-org-9224 24 8 the the DT en-wikipedia-org-9224 24 9 innate innate JJ en-wikipedia-org-9224 24 10 response response NN en-wikipedia-org-9224 24 11 , , , en-wikipedia-org-9224 24 12 vertebrates vertebrate NNS en-wikipedia-org-9224 24 13 possess possess VBP en-wikipedia-org-9224 24 14 a a DT en-wikipedia-org-9224 24 15 second second JJ en-wikipedia-org-9224 24 16 layer layer NN en-wikipedia-org-9224 24 17 of of IN en-wikipedia-org-9224 24 18 protection protection NN en-wikipedia-org-9224 24 19 , , , en-wikipedia-org-9224 24 20 the the DT en-wikipedia-org-9224 24 21 adaptive adaptive JJ en-wikipedia-org-9224 24 22 immune immune JJ en-wikipedia-org-9224 24 23 system system NN en-wikipedia-org-9224 24 24 , , , en-wikipedia-org-9224 24 25 which which WDT en-wikipedia-org-9224 24 26 is be VBZ en-wikipedia-org-9224 24 27 activated activate VBN en-wikipedia-org-9224 24 28 by by IN en-wikipedia-org-9224 24 29 the the DT en-wikipedia-org-9224 24 30 innate innate JJ en-wikipedia-org-9224 24 31 response response NN en-wikipedia-org-9224 24 32 . . . en-wikipedia-org-9224 25 1 [ [ -LRB- en-wikipedia-org-9224 25 2 3 3 LS en-wikipedia-org-9224 25 3 ] ] -RRB- en-wikipedia-org-9224 25 4 Here here RB en-wikipedia-org-9224 25 5 , , , en-wikipedia-org-9224 25 6 the the DT en-wikipedia-org-9224 25 7 immune immune JJ en-wikipedia-org-9224 25 8 system system NN en-wikipedia-org-9224 25 9 adapts adapt VBZ en-wikipedia-org-9224 25 10 its -PRON- PRP$ en-wikipedia-org-9224 25 11 response response NN en-wikipedia-org-9224 25 12 during during IN en-wikipedia-org-9224 25 13 an an DT en-wikipedia-org-9224 25 14 infection infection NN en-wikipedia-org-9224 25 15 to to TO en-wikipedia-org-9224 25 16 improve improve VB en-wikipedia-org-9224 25 17 its -PRON- PRP$ en-wikipedia-org-9224 25 18 recognition recognition NN en-wikipedia-org-9224 25 19 of of IN en-wikipedia-org-9224 25 20 the the DT en-wikipedia-org-9224 25 21 pathogen pathogen NN en-wikipedia-org-9224 25 22 . . . en-wikipedia-org-9224 26 1 This this DT en-wikipedia-org-9224 26 2 improved improved JJ en-wikipedia-org-9224 26 3 response response NN en-wikipedia-org-9224 26 4 is be VBZ en-wikipedia-org-9224 26 5 then then RB en-wikipedia-org-9224 26 6 retained retain VBN en-wikipedia-org-9224 26 7 after after IN en-wikipedia-org-9224 26 8 the the DT en-wikipedia-org-9224 26 9 pathogen pathogen NN en-wikipedia-org-9224 26 10 has have VBZ en-wikipedia-org-9224 26 11 been be VBN en-wikipedia-org-9224 26 12 eliminated eliminate VBN en-wikipedia-org-9224 26 13 , , , en-wikipedia-org-9224 26 14 in in IN en-wikipedia-org-9224 26 15 the the DT en-wikipedia-org-9224 26 16 form form NN en-wikipedia-org-9224 26 17 of of IN en-wikipedia-org-9224 26 18 an an DT en-wikipedia-org-9224 26 19 immunological immunological JJ en-wikipedia-org-9224 26 20 memory memory NN en-wikipedia-org-9224 26 21 , , , en-wikipedia-org-9224 26 22 and and CC en-wikipedia-org-9224 26 23 allows allow VBZ en-wikipedia-org-9224 26 24 the the DT en-wikipedia-org-9224 26 25 adaptive adaptive JJ en-wikipedia-org-9224 26 26 immune immune JJ en-wikipedia-org-9224 26 27 system system NN en-wikipedia-org-9224 26 28 to to TO en-wikipedia-org-9224 26 29 mount mount VB en-wikipedia-org-9224 26 30 faster fast RBR en-wikipedia-org-9224 26 31 and and CC en-wikipedia-org-9224 26 32 stronger strong JJR en-wikipedia-org-9224 26 33 attacks attack NNS en-wikipedia-org-9224 26 34 each each DT en-wikipedia-org-9224 26 35 time time NN en-wikipedia-org-9224 26 36 this this DT en-wikipedia-org-9224 26 37 pathogen pathogen NN en-wikipedia-org-9224 26 38 is be VBZ en-wikipedia-org-9224 26 39 encountered encounter VBN en-wikipedia-org-9224 26 40 . . . en-wikipedia-org-9224 27 1 [ [ -LRB- en-wikipedia-org-9224 27 2 4][5 4][5 NNP en-wikipedia-org-9224 27 3 ] ] -RRB- en-wikipedia-org-9224 27 4 Components Components NNP en-wikipedia-org-9224 27 5 of of IN en-wikipedia-org-9224 27 6 the the DT en-wikipedia-org-9224 27 7 immune immune JJ en-wikipedia-org-9224 27 8 system system NN en-wikipedia-org-9224 27 9 Innate innate VBP en-wikipedia-org-9224 27 10 immune immune JJ en-wikipedia-org-9224 27 11 system system NN en-wikipedia-org-9224 27 12 Adaptive adaptive JJ en-wikipedia-org-9224 27 13 immune immune JJ en-wikipedia-org-9224 27 14 system system NN en-wikipedia-org-9224 27 15 Response response NN en-wikipedia-org-9224 27 16 is be VBZ en-wikipedia-org-9224 27 17 non non JJ en-wikipedia-org-9224 27 18 - - JJ en-wikipedia-org-9224 27 19 specific specific JJ en-wikipedia-org-9224 27 20 Pathogen Pathogen NNP en-wikipedia-org-9224 27 21 and and CC en-wikipedia-org-9224 27 22 antigen antigen NNP en-wikipedia-org-9224 27 23 specific specific JJ en-wikipedia-org-9224 27 24 response response NN en-wikipedia-org-9224 27 25 Exposure exposure NN en-wikipedia-org-9224 27 26 leads lead VBZ en-wikipedia-org-9224 27 27 to to IN en-wikipedia-org-9224 27 28 immediate immediate JJ en-wikipedia-org-9224 27 29 maximal maximal JJ en-wikipedia-org-9224 27 30 response response NN en-wikipedia-org-9224 27 31 Lag Lag NNP en-wikipedia-org-9224 27 32 time time NN en-wikipedia-org-9224 27 33 between between IN en-wikipedia-org-9224 27 34 exposure exposure NN en-wikipedia-org-9224 27 35 and and CC en-wikipedia-org-9224 27 36 maximal maximal JJ en-wikipedia-org-9224 27 37 response response NN en-wikipedia-org-9224 27 38 Cell Cell NNP en-wikipedia-org-9224 27 39 - - HYPH en-wikipedia-org-9224 27 40 mediated mediate VBN en-wikipedia-org-9224 27 41 and and CC en-wikipedia-org-9224 27 42 humoral humoral NN en-wikipedia-org-9224 27 43 components component NNS en-wikipedia-org-9224 27 44 Cell cell NN en-wikipedia-org-9224 27 45 - - HYPH en-wikipedia-org-9224 27 46 mediated mediate VBN en-wikipedia-org-9224 27 47 and and CC en-wikipedia-org-9224 27 48 humoral humoral NN en-wikipedia-org-9224 27 49 components component NNS en-wikipedia-org-9224 27 50 No no DT en-wikipedia-org-9224 27 51 immunological immunological JJ en-wikipedia-org-9224 27 52 memory memory NN en-wikipedia-org-9224 27 53 Exposure exposure NN en-wikipedia-org-9224 27 54 leads lead VBZ en-wikipedia-org-9224 27 55 to to IN en-wikipedia-org-9224 27 56 immunological immunological JJ en-wikipedia-org-9224 27 57 memory memory NN en-wikipedia-org-9224 27 58 Found find VBN en-wikipedia-org-9224 27 59 in in IN en-wikipedia-org-9224 27 60 nearly nearly RB en-wikipedia-org-9224 27 61 all all DT en-wikipedia-org-9224 27 62 forms form NNS en-wikipedia-org-9224 27 63 of of IN en-wikipedia-org-9224 27 64 life life NN en-wikipedia-org-9224 27 65 Found find VBN en-wikipedia-org-9224 27 66 only only RB en-wikipedia-org-9224 27 67 in in IN en-wikipedia-org-9224 27 68 jawed jawed JJ en-wikipedia-org-9224 27 69 vertebrates vertebrate NNS en-wikipedia-org-9224 27 70 Both both DT en-wikipedia-org-9224 27 71 innate innate VBP en-wikipedia-org-9224 27 72 and and CC en-wikipedia-org-9224 27 73 adaptive adaptive JJ en-wikipedia-org-9224 27 74 immunity immunity NN en-wikipedia-org-9224 27 75 depend depend VBP en-wikipedia-org-9224 27 76 on on IN en-wikipedia-org-9224 27 77 the the DT en-wikipedia-org-9224 27 78 ability ability NN en-wikipedia-org-9224 27 79 of of IN en-wikipedia-org-9224 27 80 the the DT en-wikipedia-org-9224 27 81 immune immune JJ en-wikipedia-org-9224 27 82 system system NN en-wikipedia-org-9224 27 83 to to TO en-wikipedia-org-9224 27 84 distinguish distinguish VB en-wikipedia-org-9224 27 85 between between IN en-wikipedia-org-9224 27 86 self self NN en-wikipedia-org-9224 27 87 and and CC en-wikipedia-org-9224 27 88 non non JJ en-wikipedia-org-9224 27 89 - - JJ en-wikipedia-org-9224 27 90 self self JJ en-wikipedia-org-9224 27 91 molecules molecule NNS en-wikipedia-org-9224 27 92 . . . en-wikipedia-org-9224 28 1 In in IN en-wikipedia-org-9224 28 2 immunology immunology NN en-wikipedia-org-9224 28 3 , , , en-wikipedia-org-9224 28 4 self self NN en-wikipedia-org-9224 28 5 molecules molecule NNS en-wikipedia-org-9224 28 6 are be VBP en-wikipedia-org-9224 28 7 components component NNS en-wikipedia-org-9224 28 8 of of IN en-wikipedia-org-9224 28 9 an an DT en-wikipedia-org-9224 28 10 organism organism NN en-wikipedia-org-9224 28 11 's 's POS en-wikipedia-org-9224 28 12 body body NN en-wikipedia-org-9224 28 13 that that WDT en-wikipedia-org-9224 28 14 can can MD en-wikipedia-org-9224 28 15 be be VB en-wikipedia-org-9224 28 16 distinguished distinguish VBN en-wikipedia-org-9224 28 17 from from IN en-wikipedia-org-9224 28 18 foreign foreign JJ en-wikipedia-org-9224 28 19 substances substance NNS en-wikipedia-org-9224 28 20 by by IN en-wikipedia-org-9224 28 21 the the DT en-wikipedia-org-9224 28 22 immune immune JJ en-wikipedia-org-9224 28 23 system system NN en-wikipedia-org-9224 28 24 . . . en-wikipedia-org-9224 29 1 [ [ -LRB- en-wikipedia-org-9224 29 2 6 6 CD en-wikipedia-org-9224 29 3 ] ] -RRB- en-wikipedia-org-9224 29 4 Conversely conversely RB en-wikipedia-org-9224 29 5 , , , en-wikipedia-org-9224 29 6 non non JJ en-wikipedia-org-9224 29 7 - - JJ en-wikipedia-org-9224 29 8 self self JJ en-wikipedia-org-9224 29 9 molecules molecule NNS en-wikipedia-org-9224 29 10 are be VBP en-wikipedia-org-9224 29 11 those those DT en-wikipedia-org-9224 29 12 recognized recognize VBN en-wikipedia-org-9224 29 13 as as IN en-wikipedia-org-9224 29 14 foreign foreign JJ en-wikipedia-org-9224 29 15 molecules molecule NNS en-wikipedia-org-9224 29 16 . . . en-wikipedia-org-9224 30 1 One one CD en-wikipedia-org-9224 30 2 class class NN en-wikipedia-org-9224 30 3 of of IN en-wikipedia-org-9224 30 4 non non JJ en-wikipedia-org-9224 30 5 - - JJ en-wikipedia-org-9224 30 6 self self JJ en-wikipedia-org-9224 30 7 molecules molecule NNS en-wikipedia-org-9224 30 8 are be VBP en-wikipedia-org-9224 30 9 called call VBN en-wikipedia-org-9224 30 10 antigens antigen NNS en-wikipedia-org-9224 30 11 ( ( -LRB- en-wikipedia-org-9224 30 12 originally originally RB en-wikipedia-org-9224 30 13 named name VBN en-wikipedia-org-9224 30 14 for for IN en-wikipedia-org-9224 30 15 being be VBG en-wikipedia-org-9224 30 16 antibody antibody NN en-wikipedia-org-9224 30 17 generators generator NNS en-wikipedia-org-9224 30 18 ) ) -RRB- en-wikipedia-org-9224 30 19 and and CC en-wikipedia-org-9224 30 20 are be VBP en-wikipedia-org-9224 30 21 defined define VBN en-wikipedia-org-9224 30 22 as as IN en-wikipedia-org-9224 30 23 substances substance NNS en-wikipedia-org-9224 30 24 that that WDT en-wikipedia-org-9224 30 25 bind bind VBP en-wikipedia-org-9224 30 26 to to IN en-wikipedia-org-9224 30 27 specific specific JJ en-wikipedia-org-9224 30 28 immune immune JJ en-wikipedia-org-9224 30 29 receptors receptor NNS en-wikipedia-org-9224 30 30 and and CC en-wikipedia-org-9224 30 31 elicit elicit NN en-wikipedia-org-9224 30 32 an an DT en-wikipedia-org-9224 30 33 immune immune JJ en-wikipedia-org-9224 30 34 response response NN en-wikipedia-org-9224 30 35 . . . en-wikipedia-org-9224 31 1 [ [ -LRB- en-wikipedia-org-9224 31 2 7 7 CD en-wikipedia-org-9224 31 3 ] ] -RRB- en-wikipedia-org-9224 31 4 Surface Surface NNP en-wikipedia-org-9224 31 5 barriers[edit barriers[edit NFP en-wikipedia-org-9224 31 6 ] ] -RRB- en-wikipedia-org-9224 31 7 Several several JJ en-wikipedia-org-9224 31 8 barriers barrier NNS en-wikipedia-org-9224 31 9 protect protect VBP en-wikipedia-org-9224 31 10 organisms organism NNS en-wikipedia-org-9224 31 11 from from IN en-wikipedia-org-9224 31 12 infection infection NN en-wikipedia-org-9224 31 13 , , , en-wikipedia-org-9224 31 14 including include VBG en-wikipedia-org-9224 31 15 mechanical mechanical JJ en-wikipedia-org-9224 31 16 , , , en-wikipedia-org-9224 31 17 chemical chemical NN en-wikipedia-org-9224 31 18 , , , en-wikipedia-org-9224 31 19 and and CC en-wikipedia-org-9224 31 20 biological biological JJ en-wikipedia-org-9224 31 21 barriers barrier NNS en-wikipedia-org-9224 31 22 . . . en-wikipedia-org-9224 32 1 The the DT en-wikipedia-org-9224 32 2 waxy waxy NN en-wikipedia-org-9224 32 3 cuticle cuticle NN en-wikipedia-org-9224 32 4 of of IN en-wikipedia-org-9224 32 5 most most JJS en-wikipedia-org-9224 32 6 leaves leave NNS en-wikipedia-org-9224 32 7 , , , en-wikipedia-org-9224 32 8 the the DT en-wikipedia-org-9224 32 9 exoskeleton exoskeleton NN en-wikipedia-org-9224 32 10 of of IN en-wikipedia-org-9224 32 11 insects insect NNS en-wikipedia-org-9224 32 12 , , , en-wikipedia-org-9224 32 13 the the DT en-wikipedia-org-9224 32 14 shells shell NNS en-wikipedia-org-9224 32 15 and and CC en-wikipedia-org-9224 32 16 membranes membrane NNS en-wikipedia-org-9224 32 17 of of IN en-wikipedia-org-9224 32 18 externally externally RB en-wikipedia-org-9224 32 19 deposited deposit VBN en-wikipedia-org-9224 32 20 eggs egg NNS en-wikipedia-org-9224 32 21 , , , en-wikipedia-org-9224 32 22 and and CC en-wikipedia-org-9224 32 23 skin skin NN en-wikipedia-org-9224 32 24 are be VBP en-wikipedia-org-9224 32 25 examples example NNS en-wikipedia-org-9224 32 26 of of IN en-wikipedia-org-9224 32 27 mechanical mechanical JJ en-wikipedia-org-9224 32 28 barriers barrier NNS en-wikipedia-org-9224 32 29 that that WDT en-wikipedia-org-9224 32 30 are be VBP en-wikipedia-org-9224 32 31 the the DT en-wikipedia-org-9224 32 32 first first JJ en-wikipedia-org-9224 32 33 line line NN en-wikipedia-org-9224 32 34 of of IN en-wikipedia-org-9224 32 35 defense defense NN en-wikipedia-org-9224 32 36 against against IN en-wikipedia-org-9224 32 37 infection infection NN en-wikipedia-org-9224 32 38 . . . en-wikipedia-org-9224 33 1 [ [ -LRB- en-wikipedia-org-9224 33 2 8 8 CD en-wikipedia-org-9224 33 3 ] ] -RRB- en-wikipedia-org-9224 33 4 Organisms organism NNS en-wikipedia-org-9224 33 5 can can MD en-wikipedia-org-9224 33 6 not not RB en-wikipedia-org-9224 33 7 be be VB en-wikipedia-org-9224 33 8 completely completely RB en-wikipedia-org-9224 33 9 sealed seal VBN en-wikipedia-org-9224 33 10 from from IN en-wikipedia-org-9224 33 11 their -PRON- PRP$ en-wikipedia-org-9224 33 12 environments environment NNS en-wikipedia-org-9224 33 13 , , , en-wikipedia-org-9224 33 14 so so RB en-wikipedia-org-9224 33 15 systems system NNS en-wikipedia-org-9224 33 16 act act VBP en-wikipedia-org-9224 33 17 to to TO en-wikipedia-org-9224 33 18 protect protect VB en-wikipedia-org-9224 33 19 body body NN en-wikipedia-org-9224 33 20 openings opening NNS en-wikipedia-org-9224 33 21 such such JJ en-wikipedia-org-9224 33 22 as as IN en-wikipedia-org-9224 33 23 the the DT en-wikipedia-org-9224 33 24 lungs lung NNS en-wikipedia-org-9224 33 25 , , , en-wikipedia-org-9224 33 26 intestines intestine NNS en-wikipedia-org-9224 33 27 , , , en-wikipedia-org-9224 33 28 and and CC en-wikipedia-org-9224 33 29 the the DT en-wikipedia-org-9224 33 30 genitourinary genitourinary JJ en-wikipedia-org-9224 33 31 tract tract NN en-wikipedia-org-9224 33 32 . . . en-wikipedia-org-9224 34 1 In in IN en-wikipedia-org-9224 34 2 the the DT en-wikipedia-org-9224 34 3 lungs lung NNS en-wikipedia-org-9224 34 4 , , , en-wikipedia-org-9224 34 5 coughing cough VBG en-wikipedia-org-9224 34 6 and and CC en-wikipedia-org-9224 34 7 sneezing sneeze VBG en-wikipedia-org-9224 34 8 mechanically mechanically RB en-wikipedia-org-9224 34 9 eject eject VBP en-wikipedia-org-9224 34 10 pathogens pathogen NNS en-wikipedia-org-9224 34 11 and and CC en-wikipedia-org-9224 34 12 other other JJ en-wikipedia-org-9224 34 13 irritants irritant NNS en-wikipedia-org-9224 34 14 from from IN en-wikipedia-org-9224 34 15 the the DT en-wikipedia-org-9224 34 16 respiratory respiratory JJ en-wikipedia-org-9224 34 17 tract tract NN en-wikipedia-org-9224 34 18 . . . en-wikipedia-org-9224 35 1 The the DT en-wikipedia-org-9224 35 2 flushing flush VBG en-wikipedia-org-9224 35 3 action action NN en-wikipedia-org-9224 35 4 of of IN en-wikipedia-org-9224 35 5 tears tear NNS en-wikipedia-org-9224 35 6 and and CC en-wikipedia-org-9224 35 7 urine urine NN en-wikipedia-org-9224 35 8 also also RB en-wikipedia-org-9224 35 9 mechanically mechanically RB en-wikipedia-org-9224 35 10 expels expel VBZ en-wikipedia-org-9224 35 11 pathogens pathogen NNS en-wikipedia-org-9224 35 12 , , , en-wikipedia-org-9224 35 13 while while IN en-wikipedia-org-9224 35 14 mucus mucus NN en-wikipedia-org-9224 35 15 secreted secrete VBN en-wikipedia-org-9224 35 16 by by IN en-wikipedia-org-9224 35 17 the the DT en-wikipedia-org-9224 35 18 respiratory respiratory JJ en-wikipedia-org-9224 35 19 and and CC en-wikipedia-org-9224 35 20 gastrointestinal gastrointestinal JJ en-wikipedia-org-9224 35 21 tract tract NN en-wikipedia-org-9224 35 22 serves serve VBZ en-wikipedia-org-9224 35 23 to to IN en-wikipedia-org-9224 35 24 trap trap NN en-wikipedia-org-9224 35 25 and and CC en-wikipedia-org-9224 35 26 entangle entangle JJ en-wikipedia-org-9224 35 27 microorganisms microorganism NNS en-wikipedia-org-9224 35 28 . . . en-wikipedia-org-9224 36 1 [ [ -LRB- en-wikipedia-org-9224 36 2 9 9 CD en-wikipedia-org-9224 36 3 ] ] -RRB- en-wikipedia-org-9224 36 4 Chemical chemical NN en-wikipedia-org-9224 36 5 barriers barrier NNS en-wikipedia-org-9224 36 6 also also RB en-wikipedia-org-9224 36 7 protect protect VBP en-wikipedia-org-9224 36 8 against against IN en-wikipedia-org-9224 36 9 infection infection NN en-wikipedia-org-9224 36 10 . . . en-wikipedia-org-9224 37 1 The the DT en-wikipedia-org-9224 37 2 skin skin NN en-wikipedia-org-9224 37 3 and and CC en-wikipedia-org-9224 37 4 respiratory respiratory JJ en-wikipedia-org-9224 37 5 tract tract NN en-wikipedia-org-9224 37 6 secrete secrete NN en-wikipedia-org-9224 37 7 antimicrobial antimicrobial JJ en-wikipedia-org-9224 37 8 peptides peptide NNS en-wikipedia-org-9224 37 9 such such JJ en-wikipedia-org-9224 37 10 as as IN en-wikipedia-org-9224 37 11 the the DT en-wikipedia-org-9224 37 12 β β NNP en-wikipedia-org-9224 37 13 - - HYPH en-wikipedia-org-9224 37 14 defensins defensins NNP en-wikipedia-org-9224 37 15 . . . en-wikipedia-org-9224 38 1 [ [ -LRB- en-wikipedia-org-9224 38 2 10 10 CD en-wikipedia-org-9224 38 3 ] ] -RRB- en-wikipedia-org-9224 38 4 Enzymes enzyme NNS en-wikipedia-org-9224 38 5 such such JJ en-wikipedia-org-9224 38 6 as as IN en-wikipedia-org-9224 38 7 lysozyme lysozyme NNS en-wikipedia-org-9224 38 8 and and CC en-wikipedia-org-9224 38 9 phospholipase phospholipase NN en-wikipedia-org-9224 38 10 A2 A2 NNP en-wikipedia-org-9224 38 11 in in IN en-wikipedia-org-9224 38 12 saliva saliva NNP en-wikipedia-org-9224 38 13 , , , en-wikipedia-org-9224 38 14 tears tear NNS en-wikipedia-org-9224 38 15 , , , en-wikipedia-org-9224 38 16 and and CC en-wikipedia-org-9224 38 17 breast breast NN en-wikipedia-org-9224 38 18 milk milk NN en-wikipedia-org-9224 38 19 are be VBP en-wikipedia-org-9224 38 20 also also RB en-wikipedia-org-9224 38 21 antibacterials antibacterial NNS en-wikipedia-org-9224 38 22 . . . en-wikipedia-org-9224 39 1 [ [ -LRB- en-wikipedia-org-9224 39 2 11][12 11][12 CD en-wikipedia-org-9224 39 3 ] ] -RRB- en-wikipedia-org-9224 39 4 Vaginal vaginal JJ en-wikipedia-org-9224 39 5 secretions secretion NNS en-wikipedia-org-9224 39 6 serve serve VBP en-wikipedia-org-9224 39 7 as as IN en-wikipedia-org-9224 39 8 a a DT en-wikipedia-org-9224 39 9 chemical chemical NN en-wikipedia-org-9224 39 10 barrier barrier NN en-wikipedia-org-9224 39 11 following follow VBG en-wikipedia-org-9224 39 12 menarche menarche NNP en-wikipedia-org-9224 39 13 , , , en-wikipedia-org-9224 39 14 when when WRB en-wikipedia-org-9224 39 15 they -PRON- PRP en-wikipedia-org-9224 39 16 become become VBP en-wikipedia-org-9224 39 17 slightly slightly RB en-wikipedia-org-9224 39 18 acidic acidic JJ en-wikipedia-org-9224 39 19 , , , en-wikipedia-org-9224 39 20 while while IN en-wikipedia-org-9224 39 21 semen semen NNP en-wikipedia-org-9224 39 22 contains contain VBZ en-wikipedia-org-9224 39 23 defensins defensin NNS en-wikipedia-org-9224 39 24 and and CC en-wikipedia-org-9224 39 25 zinc zinc NN en-wikipedia-org-9224 39 26 to to TO en-wikipedia-org-9224 39 27 kill kill VB en-wikipedia-org-9224 39 28 pathogens pathogen NNS en-wikipedia-org-9224 39 29 . . . en-wikipedia-org-9224 40 1 [ [ -LRB- en-wikipedia-org-9224 40 2 13][14 13][14 CD en-wikipedia-org-9224 40 3 ] ] -RRB- en-wikipedia-org-9224 40 4 In in IN en-wikipedia-org-9224 40 5 the the DT en-wikipedia-org-9224 40 6 stomach stomach NN en-wikipedia-org-9224 40 7 , , , en-wikipedia-org-9224 40 8 gastric gastric JJ en-wikipedia-org-9224 40 9 acid acid NN en-wikipedia-org-9224 40 10 serves serve VBZ en-wikipedia-org-9224 40 11 as as IN en-wikipedia-org-9224 40 12 a a DT en-wikipedia-org-9224 40 13 chemical chemical NN en-wikipedia-org-9224 40 14 defense defense NN en-wikipedia-org-9224 40 15 against against IN en-wikipedia-org-9224 40 16 ingested ingested JJ en-wikipedia-org-9224 40 17 pathogens pathogen NNS en-wikipedia-org-9224 40 18 . . . en-wikipedia-org-9224 41 1 [ [ -LRB- en-wikipedia-org-9224 41 2 15 15 CD en-wikipedia-org-9224 41 3 ] ] -RRB- en-wikipedia-org-9224 41 4 Within within IN en-wikipedia-org-9224 41 5 the the DT en-wikipedia-org-9224 41 6 genitourinary genitourinary JJ en-wikipedia-org-9224 41 7 and and CC en-wikipedia-org-9224 41 8 gastrointestinal gastrointestinal JJ en-wikipedia-org-9224 41 9 tracts tract NNS en-wikipedia-org-9224 41 10 , , , en-wikipedia-org-9224 41 11 commensal commensal NN en-wikipedia-org-9224 41 12 flora flora NNS en-wikipedia-org-9224 41 13 serve serve VBP en-wikipedia-org-9224 41 14 as as IN en-wikipedia-org-9224 41 15 biological biological JJ en-wikipedia-org-9224 41 16 barriers barrier NNS en-wikipedia-org-9224 41 17 by by IN en-wikipedia-org-9224 41 18 competing compete VBG en-wikipedia-org-9224 41 19 with with IN en-wikipedia-org-9224 41 20 pathogenic pathogenic JJ en-wikipedia-org-9224 41 21 bacteria bacteria NNS en-wikipedia-org-9224 41 22 for for IN en-wikipedia-org-9224 41 23 food food NN en-wikipedia-org-9224 41 24 and and CC en-wikipedia-org-9224 41 25 space space NN en-wikipedia-org-9224 41 26 and and CC en-wikipedia-org-9224 41 27 , , , en-wikipedia-org-9224 41 28 in in IN en-wikipedia-org-9224 41 29 some some DT en-wikipedia-org-9224 41 30 cases case NNS en-wikipedia-org-9224 41 31 , , , en-wikipedia-org-9224 41 32 changing change VBG en-wikipedia-org-9224 41 33 the the DT en-wikipedia-org-9224 41 34 conditions condition NNS en-wikipedia-org-9224 41 35 in in IN en-wikipedia-org-9224 41 36 their -PRON- PRP$ en-wikipedia-org-9224 41 37 environment environment NN en-wikipedia-org-9224 41 38 , , , en-wikipedia-org-9224 41 39 such such JJ en-wikipedia-org-9224 41 40 as as IN en-wikipedia-org-9224 41 41 pH pH NNP en-wikipedia-org-9224 41 42 or or CC en-wikipedia-org-9224 41 43 available available JJ en-wikipedia-org-9224 41 44 iron iron NN en-wikipedia-org-9224 41 45 . . . en-wikipedia-org-9224 42 1 As as IN en-wikipedia-org-9224 42 2 a a DT en-wikipedia-org-9224 42 3 result result NN en-wikipedia-org-9224 42 4 , , , en-wikipedia-org-9224 42 5 the the DT en-wikipedia-org-9224 42 6 probability probability NN en-wikipedia-org-9224 42 7 that that WDT en-wikipedia-org-9224 42 8 pathogens pathogens NNP en-wikipedia-org-9224 42 9 will will MD en-wikipedia-org-9224 42 10 reach reach VB en-wikipedia-org-9224 42 11 sufficient sufficient JJ en-wikipedia-org-9224 42 12 numbers number NNS en-wikipedia-org-9224 42 13 to to TO en-wikipedia-org-9224 42 14 cause cause VB en-wikipedia-org-9224 42 15 illness illness NN en-wikipedia-org-9224 42 16 is be VBZ en-wikipedia-org-9224 42 17 reduced reduce VBN en-wikipedia-org-9224 42 18 . . . en-wikipedia-org-9224 43 1 [ [ -LRB- en-wikipedia-org-9224 43 2 16 16 CD en-wikipedia-org-9224 43 3 ] ] -RRB- en-wikipedia-org-9224 43 4 Innate innate VB en-wikipedia-org-9224 43 5 immune immune JJ en-wikipedia-org-9224 43 6 system[edit system[edit . en-wikipedia-org-9224 43 7 ] ] -RRB- en-wikipedia-org-9224 43 8 Further further JJ en-wikipedia-org-9224 43 9 information information NN en-wikipedia-org-9224 43 10 : : : en-wikipedia-org-9224 43 11 Innate innate VB en-wikipedia-org-9224 43 12 immune immune JJ en-wikipedia-org-9224 43 13 system system NN en-wikipedia-org-9224 43 14 Microorganisms microorganism NNS en-wikipedia-org-9224 43 15 or or CC en-wikipedia-org-9224 43 16 toxins toxin NNS en-wikipedia-org-9224 43 17 that that WDT en-wikipedia-org-9224 43 18 successfully successfully RB en-wikipedia-org-9224 43 19 enter enter VBP en-wikipedia-org-9224 43 20 an an DT en-wikipedia-org-9224 43 21 organism organism NN en-wikipedia-org-9224 43 22 encounter encounter VB en-wikipedia-org-9224 43 23 the the DT en-wikipedia-org-9224 43 24 cells cell NNS en-wikipedia-org-9224 43 25 and and CC en-wikipedia-org-9224 43 26 mechanisms mechanism NNS en-wikipedia-org-9224 43 27 of of IN en-wikipedia-org-9224 43 28 the the DT en-wikipedia-org-9224 43 29 innate innate JJ en-wikipedia-org-9224 43 30 immune immune JJ en-wikipedia-org-9224 43 31 system system NN en-wikipedia-org-9224 43 32 . . . en-wikipedia-org-9224 44 1 The the DT en-wikipedia-org-9224 44 2 innate innate JJ en-wikipedia-org-9224 44 3 response response NN en-wikipedia-org-9224 44 4 is be VBZ en-wikipedia-org-9224 44 5 usually usually RB en-wikipedia-org-9224 44 6 triggered trigger VBN en-wikipedia-org-9224 44 7 when when WRB en-wikipedia-org-9224 44 8 microbes microbe NNS en-wikipedia-org-9224 44 9 are be VBP en-wikipedia-org-9224 44 10 identified identify VBN en-wikipedia-org-9224 44 11 by by IN en-wikipedia-org-9224 44 12 pattern pattern NN en-wikipedia-org-9224 44 13 recognition recognition NN en-wikipedia-org-9224 44 14 receptors receptor NNS en-wikipedia-org-9224 44 15 , , , en-wikipedia-org-9224 44 16 which which WDT en-wikipedia-org-9224 44 17 recognize recognize VBP en-wikipedia-org-9224 44 18 components component NNS en-wikipedia-org-9224 44 19 that that WDT en-wikipedia-org-9224 44 20 are be VBP en-wikipedia-org-9224 44 21 conserved conserve VBN en-wikipedia-org-9224 44 22 among among IN en-wikipedia-org-9224 44 23 broad broad JJ en-wikipedia-org-9224 44 24 groups group NNS en-wikipedia-org-9224 44 25 of of IN en-wikipedia-org-9224 44 26 microorganisms,[17 microorganisms,[17 NN en-wikipedia-org-9224 44 27 ] ] -RRB- en-wikipedia-org-9224 44 28 or or CC en-wikipedia-org-9224 44 29 when when WRB en-wikipedia-org-9224 44 30 damaged damage VBN en-wikipedia-org-9224 44 31 , , , en-wikipedia-org-9224 44 32 injured injure VBN en-wikipedia-org-9224 44 33 or or CC en-wikipedia-org-9224 44 34 stressed stressed JJ en-wikipedia-org-9224 44 35 cells cell NNS en-wikipedia-org-9224 44 36 send send VBP en-wikipedia-org-9224 44 37 out out RP en-wikipedia-org-9224 44 38 alarm alarm NN en-wikipedia-org-9224 44 39 signals signal NNS en-wikipedia-org-9224 44 40 , , , en-wikipedia-org-9224 44 41 many many DT en-wikipedia-org-9224 44 42 of of IN en-wikipedia-org-9224 44 43 which which WDT en-wikipedia-org-9224 44 44 are be VBP en-wikipedia-org-9224 44 45 recognized recognize VBN en-wikipedia-org-9224 44 46 by by IN en-wikipedia-org-9224 44 47 the the DT en-wikipedia-org-9224 44 48 same same JJ en-wikipedia-org-9224 44 49 receptors receptor NNS en-wikipedia-org-9224 44 50 as as IN en-wikipedia-org-9224 44 51 those those DT en-wikipedia-org-9224 44 52 that that WDT en-wikipedia-org-9224 44 53 recognize recognize VBP en-wikipedia-org-9224 44 54 pathogens pathogen NNS en-wikipedia-org-9224 44 55 . . . en-wikipedia-org-9224 45 1 [ [ -LRB- en-wikipedia-org-9224 45 2 18 18 CD en-wikipedia-org-9224 45 3 ] ] -RRB- en-wikipedia-org-9224 45 4 Innate innate VB en-wikipedia-org-9224 45 5 immune immune JJ en-wikipedia-org-9224 45 6 defenses defense NNS en-wikipedia-org-9224 45 7 are be VBP en-wikipedia-org-9224 45 8 non non JJ en-wikipedia-org-9224 45 9 - - JJ en-wikipedia-org-9224 45 10 specific specific JJ en-wikipedia-org-9224 45 11 , , , en-wikipedia-org-9224 45 12 meaning mean VBG en-wikipedia-org-9224 45 13 these these DT en-wikipedia-org-9224 45 14 systems system NNS en-wikipedia-org-9224 45 15 respond respond VBP en-wikipedia-org-9224 45 16 to to IN en-wikipedia-org-9224 45 17 pathogens pathogen NNS en-wikipedia-org-9224 45 18 in in IN en-wikipedia-org-9224 45 19 a a DT en-wikipedia-org-9224 45 20 generic generic JJ en-wikipedia-org-9224 45 21 way way NN en-wikipedia-org-9224 45 22 . . . en-wikipedia-org-9224 46 1 [ [ -LRB- en-wikipedia-org-9224 46 2 19 19 CD en-wikipedia-org-9224 46 3 ] ] -RRB- en-wikipedia-org-9224 46 4 This this DT en-wikipedia-org-9224 46 5 system system NN en-wikipedia-org-9224 46 6 does do VBZ en-wikipedia-org-9224 46 7 not not RB en-wikipedia-org-9224 46 8 confer confer VB en-wikipedia-org-9224 46 9 long long RB en-wikipedia-org-9224 46 10 - - HYPH en-wikipedia-org-9224 46 11 lasting last VBG en-wikipedia-org-9224 46 12 immunity immunity NN en-wikipedia-org-9224 46 13 against against IN en-wikipedia-org-9224 46 14 a a DT en-wikipedia-org-9224 46 15 pathogen pathogen NN en-wikipedia-org-9224 46 16 . . . en-wikipedia-org-9224 47 1 The the DT en-wikipedia-org-9224 47 2 innate innate JJ en-wikipedia-org-9224 47 3 immune immune JJ en-wikipedia-org-9224 47 4 system system NN en-wikipedia-org-9224 47 5 is be VBZ en-wikipedia-org-9224 47 6 the the DT en-wikipedia-org-9224 47 7 dominant dominant JJ en-wikipedia-org-9224 47 8 system system NN en-wikipedia-org-9224 47 9 of of IN en-wikipedia-org-9224 47 10 host host NN en-wikipedia-org-9224 47 11 defense defense NN en-wikipedia-org-9224 47 12 in in IN en-wikipedia-org-9224 47 13 most most JJS en-wikipedia-org-9224 47 14 organisms,[2 organisms,[2 JJ en-wikipedia-org-9224 47 15 ] ] -RRB- en-wikipedia-org-9224 47 16 and and CC en-wikipedia-org-9224 47 17 the the DT en-wikipedia-org-9224 47 18 only only JJ en-wikipedia-org-9224 47 19 one one CD en-wikipedia-org-9224 47 20 in in IN en-wikipedia-org-9224 47 21 plants plant NNS en-wikipedia-org-9224 47 22 . . . en-wikipedia-org-9224 48 1 [ [ -LRB- en-wikipedia-org-9224 48 2 20 20 CD en-wikipedia-org-9224 48 3 ] ] -RRB- en-wikipedia-org-9224 48 4 Immune immune JJ en-wikipedia-org-9224 48 5 sensing[edit sensing[edit NFP en-wikipedia-org-9224 48 6 ] ] -RRB- en-wikipedia-org-9224 48 7 Cells cell NNS en-wikipedia-org-9224 48 8 in in IN en-wikipedia-org-9224 48 9 the the DT en-wikipedia-org-9224 48 10 innate innate JJ en-wikipedia-org-9224 48 11 immune immune JJ en-wikipedia-org-9224 48 12 system system NN en-wikipedia-org-9224 48 13 use use NN en-wikipedia-org-9224 48 14 pattern pattern NN en-wikipedia-org-9224 48 15 recognition recognition NN en-wikipedia-org-9224 48 16 receptors receptor NNS en-wikipedia-org-9224 48 17 to to TO en-wikipedia-org-9224 48 18 recognize recognize VB en-wikipedia-org-9224 48 19 molecular molecular JJ en-wikipedia-org-9224 48 20 structures structure NNS en-wikipedia-org-9224 48 21 that that WDT en-wikipedia-org-9224 48 22 are be VBP en-wikipedia-org-9224 48 23 produced produce VBN en-wikipedia-org-9224 48 24 by by IN en-wikipedia-org-9224 48 25 pathogens pathogen NNS en-wikipedia-org-9224 48 26 . . . en-wikipedia-org-9224 49 1 [ [ -LRB- en-wikipedia-org-9224 49 2 21 21 CD en-wikipedia-org-9224 49 3 ] ] -RRB- en-wikipedia-org-9224 49 4 They -PRON- PRP en-wikipedia-org-9224 49 5 are be VBP en-wikipedia-org-9224 49 6 proteins protein NNS en-wikipedia-org-9224 49 7 expressed express VBN en-wikipedia-org-9224 49 8 , , , en-wikipedia-org-9224 49 9 mainly mainly RB en-wikipedia-org-9224 49 10 , , , en-wikipedia-org-9224 49 11 by by IN en-wikipedia-org-9224 49 12 cells cell NNS en-wikipedia-org-9224 49 13 of of IN en-wikipedia-org-9224 49 14 the the DT en-wikipedia-org-9224 49 15 innate innate JJ en-wikipedia-org-9224 49 16 immune immune JJ en-wikipedia-org-9224 49 17 system system NN en-wikipedia-org-9224 49 18 , , , en-wikipedia-org-9224 49 19 such such JJ en-wikipedia-org-9224 49 20 as as IN en-wikipedia-org-9224 49 21 dendritic dendritic JJ en-wikipedia-org-9224 49 22 cells cell NNS en-wikipedia-org-9224 49 23 , , , en-wikipedia-org-9224 49 24 macrophages macrophage NNS en-wikipedia-org-9224 49 25 , , , en-wikipedia-org-9224 49 26 monocytes monocyte NNS en-wikipedia-org-9224 49 27 , , , en-wikipedia-org-9224 49 28 neutrophils neutrophil NNS en-wikipedia-org-9224 49 29 and and CC en-wikipedia-org-9224 49 30 epithelial epithelial NNP en-wikipedia-org-9224 49 31 cells[19][22 cells[19][22 NNP en-wikipedia-org-9224 49 32 ] ] -RRB- en-wikipedia-org-9224 49 33 to to TO en-wikipedia-org-9224 49 34 identify identify VB en-wikipedia-org-9224 49 35 two two CD en-wikipedia-org-9224 49 36 classes class NNS en-wikipedia-org-9224 49 37 of of IN en-wikipedia-org-9224 49 38 molecules molecule NNS en-wikipedia-org-9224 49 39 : : : en-wikipedia-org-9224 49 40 pathogen pathogen NNP en-wikipedia-org-9224 49 41 - - HYPH en-wikipedia-org-9224 49 42 associated associate VBN en-wikipedia-org-9224 49 43 molecular molecular JJ en-wikipedia-org-9224 49 44 patterns pattern NNS en-wikipedia-org-9224 49 45 ( ( -LRB- en-wikipedia-org-9224 49 46 PAMPs PAMPs NNP en-wikipedia-org-9224 49 47 ) ) -RRB- en-wikipedia-org-9224 49 48 , , , en-wikipedia-org-9224 49 49 which which WDT en-wikipedia-org-9224 49 50 are be VBP en-wikipedia-org-9224 49 51 associated associate VBN en-wikipedia-org-9224 49 52 with with IN en-wikipedia-org-9224 49 53 microbial microbial JJ en-wikipedia-org-9224 49 54 pathogens pathogen NNS en-wikipedia-org-9224 49 55 , , , en-wikipedia-org-9224 49 56 and and CC en-wikipedia-org-9224 49 57 damage damage NN en-wikipedia-org-9224 49 58 - - HYPH en-wikipedia-org-9224 49 59 associated associate VBN en-wikipedia-org-9224 49 60 molecular molecular JJ en-wikipedia-org-9224 49 61 patterns pattern NNS en-wikipedia-org-9224 49 62 ( ( -LRB- en-wikipedia-org-9224 49 63 DAMPs DAMPs NNP en-wikipedia-org-9224 49 64 ) ) -RRB- en-wikipedia-org-9224 49 65 , , , en-wikipedia-org-9224 49 66 which which WDT en-wikipedia-org-9224 49 67 are be VBP en-wikipedia-org-9224 49 68 associated associate VBN en-wikipedia-org-9224 49 69 with with IN en-wikipedia-org-9224 49 70 components component NNS en-wikipedia-org-9224 49 71 of of IN en-wikipedia-org-9224 49 72 host host NN en-wikipedia-org-9224 49 73 's 's POS en-wikipedia-org-9224 49 74 cells cell NNS en-wikipedia-org-9224 49 75 that that WDT en-wikipedia-org-9224 49 76 are be VBP en-wikipedia-org-9224 49 77 released release VBN en-wikipedia-org-9224 49 78 during during IN en-wikipedia-org-9224 49 79 cell cell NN en-wikipedia-org-9224 49 80 damage damage NN en-wikipedia-org-9224 49 81 or or CC en-wikipedia-org-9224 49 82 cell cell NN en-wikipedia-org-9224 49 83 death death NN en-wikipedia-org-9224 49 84 . . . en-wikipedia-org-9224 50 1 [ [ -LRB- en-wikipedia-org-9224 50 2 23 23 CD en-wikipedia-org-9224 50 3 ] ] -RRB- en-wikipedia-org-9224 50 4 Recognition Recognition NNP en-wikipedia-org-9224 50 5 of of IN en-wikipedia-org-9224 50 6 extracellular extracellular NNP en-wikipedia-org-9224 50 7 or or CC en-wikipedia-org-9224 50 8 endosomal endosomal JJ en-wikipedia-org-9224 50 9 PAMPs PAMPs NNP en-wikipedia-org-9224 50 10 is be VBZ en-wikipedia-org-9224 50 11 mediated mediate VBN en-wikipedia-org-9224 50 12 by by IN en-wikipedia-org-9224 50 13 transmembrane transmembrane JJ en-wikipedia-org-9224 50 14 proteins protein NNS en-wikipedia-org-9224 50 15 known know VBN en-wikipedia-org-9224 50 16 as as IN en-wikipedia-org-9224 50 17 toll toll NN en-wikipedia-org-9224 50 18 - - HYPH en-wikipedia-org-9224 50 19 like like JJ en-wikipedia-org-9224 50 20 receptors receptor NNS en-wikipedia-org-9224 50 21 ( ( -LRB- en-wikipedia-org-9224 50 22 TLRs TLRs NNP en-wikipedia-org-9224 50 23 ) ) -RRB- en-wikipedia-org-9224 50 24 . . . en-wikipedia-org-9224 51 1 [ [ -LRB- en-wikipedia-org-9224 51 2 24 24 CD en-wikipedia-org-9224 51 3 ] ] -RRB- en-wikipedia-org-9224 51 4 TLRs tlr NNS en-wikipedia-org-9224 51 5 share share VBP en-wikipedia-org-9224 51 6 a a DT en-wikipedia-org-9224 51 7 typical typical JJ en-wikipedia-org-9224 51 8 structural structural JJ en-wikipedia-org-9224 51 9 motif motif NN en-wikipedia-org-9224 51 10 , , , en-wikipedia-org-9224 51 11 the the DT en-wikipedia-org-9224 51 12 leucine leucine NN en-wikipedia-org-9224 51 13 rich rich JJ en-wikipedia-org-9224 51 14 repeats repeat NNS en-wikipedia-org-9224 51 15 ( ( -LRB- en-wikipedia-org-9224 51 16 LRR LRR NNP en-wikipedia-org-9224 51 17 ) ) -RRB- en-wikipedia-org-9224 51 18 , , , en-wikipedia-org-9224 51 19 which which WDT en-wikipedia-org-9224 51 20 give give VBP en-wikipedia-org-9224 51 21 them -PRON- PRP en-wikipedia-org-9224 51 22 a a DT en-wikipedia-org-9224 51 23 curved curved JJ en-wikipedia-org-9224 51 24 shape shape NN en-wikipedia-org-9224 51 25 . . . en-wikipedia-org-9224 52 1 [ [ -LRB- en-wikipedia-org-9224 52 2 25 25 CD en-wikipedia-org-9224 52 3 ] ] -RRB- en-wikipedia-org-9224 52 4 Toll toll NN en-wikipedia-org-9224 52 5 - - HYPH en-wikipedia-org-9224 52 6 like like JJ en-wikipedia-org-9224 52 7 receptors receptor NNS en-wikipedia-org-9224 52 8 were be VBD en-wikipedia-org-9224 52 9 first first RB en-wikipedia-org-9224 52 10 discovered discover VBN en-wikipedia-org-9224 52 11 in in IN en-wikipedia-org-9224 52 12 Drosophila Drosophila NNP en-wikipedia-org-9224 52 13 and and CC en-wikipedia-org-9224 52 14 trigger trigger VB en-wikipedia-org-9224 52 15 the the DT en-wikipedia-org-9224 52 16 synthesis synthesis NN en-wikipedia-org-9224 52 17 and and CC en-wikipedia-org-9224 52 18 secretion secretion NN en-wikipedia-org-9224 52 19 of of IN en-wikipedia-org-9224 52 20 cytokines cytokine NNS en-wikipedia-org-9224 52 21 and and CC en-wikipedia-org-9224 52 22 activation activation NN en-wikipedia-org-9224 52 23 of of IN en-wikipedia-org-9224 52 24 other other JJ en-wikipedia-org-9224 52 25 host host NN en-wikipedia-org-9224 52 26 defense defense NN en-wikipedia-org-9224 52 27 programs program NNS en-wikipedia-org-9224 52 28 that that WDT en-wikipedia-org-9224 52 29 are be VBP en-wikipedia-org-9224 52 30 necessary necessary JJ en-wikipedia-org-9224 52 31 for for IN en-wikipedia-org-9224 52 32 both both CC en-wikipedia-org-9224 52 33 innate innate VBP en-wikipedia-org-9224 52 34 or or CC en-wikipedia-org-9224 52 35 adaptive adaptive JJ en-wikipedia-org-9224 52 36 immune immune JJ en-wikipedia-org-9224 52 37 responses response NNS en-wikipedia-org-9224 52 38 . . . en-wikipedia-org-9224 53 1 Ten ten CD en-wikipedia-org-9224 53 2 toll toll NN en-wikipedia-org-9224 53 3 - - HYPH en-wikipedia-org-9224 53 4 like like JJ en-wikipedia-org-9224 53 5 receptors receptor NNS en-wikipedia-org-9224 53 6 have have VBP en-wikipedia-org-9224 53 7 been be VBN en-wikipedia-org-9224 53 8 described describe VBN en-wikipedia-org-9224 53 9 in in IN en-wikipedia-org-9224 53 10 humans human NNS en-wikipedia-org-9224 53 11 . . . en-wikipedia-org-9224 54 1 [ [ -LRB- en-wikipedia-org-9224 54 2 26 26 CD en-wikipedia-org-9224 54 3 ] ] -RRB- en-wikipedia-org-9224 54 4 Cells cell NNS en-wikipedia-org-9224 54 5 in in IN en-wikipedia-org-9224 54 6 the the DT en-wikipedia-org-9224 54 7 innate innate JJ en-wikipedia-org-9224 54 8 immune immune JJ en-wikipedia-org-9224 54 9 system system NN en-wikipedia-org-9224 54 10 have have VBP en-wikipedia-org-9224 54 11 pattern pattern NN en-wikipedia-org-9224 54 12 recognition recognition NN en-wikipedia-org-9224 54 13 receptors receptor NNS en-wikipedia-org-9224 54 14 , , , en-wikipedia-org-9224 54 15 which which WDT en-wikipedia-org-9224 54 16 detect detect VBP en-wikipedia-org-9224 54 17 infection infection NN en-wikipedia-org-9224 54 18 or or CC en-wikipedia-org-9224 54 19 cell cell NN en-wikipedia-org-9224 54 20 damage damage NN en-wikipedia-org-9224 54 21 , , , en-wikipedia-org-9224 54 22 inside inside RB en-wikipedia-org-9224 54 23 . . . en-wikipedia-org-9224 55 1 Three three CD en-wikipedia-org-9224 55 2 major major JJ en-wikipedia-org-9224 55 3 classes class NNS en-wikipedia-org-9224 55 4 of of IN en-wikipedia-org-9224 55 5 these these DT en-wikipedia-org-9224 55 6 " " `` en-wikipedia-org-9224 55 7 cytosolic cytosolic JJ en-wikipedia-org-9224 55 8 " " '' en-wikipedia-org-9224 55 9 receptors receptor NNS en-wikipedia-org-9224 55 10 are be VBP en-wikipedia-org-9224 55 11 NOD NOD NNP en-wikipedia-org-9224 55 12 – – : en-wikipedia-org-9224 55 13 like like IN en-wikipedia-org-9224 55 14 receptors receptor NNS en-wikipedia-org-9224 55 15 , , , en-wikipedia-org-9224 55 16 RIG RIG NNP en-wikipedia-org-9224 55 17 ( ( -LRB- en-wikipedia-org-9224 55 18 retinoic retinoic NNP en-wikipedia-org-9224 55 19 acid acid NN en-wikipedia-org-9224 55 20 - - HYPH en-wikipedia-org-9224 55 21 inducible inducible JJ en-wikipedia-org-9224 55 22 gene)-like gene)-like NNP en-wikipedia-org-9224 55 23 receptors receptor NNS en-wikipedia-org-9224 55 24 , , , en-wikipedia-org-9224 55 25 and and CC en-wikipedia-org-9224 55 26 cytosolic cytosolic JJ en-wikipedia-org-9224 55 27 DNA DNA NNP en-wikipedia-org-9224 55 28 sensors sensor NNS en-wikipedia-org-9224 55 29 . . . en-wikipedia-org-9224 56 1 [ [ -LRB- en-wikipedia-org-9224 56 2 27 27 CD en-wikipedia-org-9224 56 3 ] ] -RRB- en-wikipedia-org-9224 56 4 Innate innate VB en-wikipedia-org-9224 56 5 immune immune JJ en-wikipedia-org-9224 56 6 cells[edit cells[edit NFP en-wikipedia-org-9224 56 7 ] ] -RRB- en-wikipedia-org-9224 56 8 A a DT en-wikipedia-org-9224 56 9 scanning scan VBG en-wikipedia-org-9224 56 10 electron electron NN en-wikipedia-org-9224 56 11 microscope microscope NN en-wikipedia-org-9224 56 12 image image NN en-wikipedia-org-9224 56 13 of of IN en-wikipedia-org-9224 56 14 normal normal JJ en-wikipedia-org-9224 56 15 circulating circulate VBG en-wikipedia-org-9224 56 16 human human JJ en-wikipedia-org-9224 56 17 blood blood NN en-wikipedia-org-9224 56 18 . . . en-wikipedia-org-9224 57 1 One one PRP en-wikipedia-org-9224 57 2 can can MD en-wikipedia-org-9224 57 3 see see VB en-wikipedia-org-9224 57 4 red red JJ en-wikipedia-org-9224 57 5 blood blood NN en-wikipedia-org-9224 57 6 cells cell NNS en-wikipedia-org-9224 57 7 , , , en-wikipedia-org-9224 57 8 several several JJ en-wikipedia-org-9224 57 9 knobby knobby NNP en-wikipedia-org-9224 57 10 white white JJ en-wikipedia-org-9224 57 11 blood blood NN en-wikipedia-org-9224 57 12 cells cell NNS en-wikipedia-org-9224 57 13 including include VBG en-wikipedia-org-9224 57 14 lymphocytes lymphocyte NNS en-wikipedia-org-9224 57 15 , , , en-wikipedia-org-9224 57 16 a a DT en-wikipedia-org-9224 57 17 monocyte monocyte NN en-wikipedia-org-9224 57 18 , , , en-wikipedia-org-9224 57 19 a a DT en-wikipedia-org-9224 57 20 neutrophil neutrophil NN en-wikipedia-org-9224 57 21 , , , en-wikipedia-org-9224 57 22 and and CC en-wikipedia-org-9224 57 23 many many JJ en-wikipedia-org-9224 57 24 small small JJ en-wikipedia-org-9224 57 25 disc disc NN en-wikipedia-org-9224 57 26 - - HYPH en-wikipedia-org-9224 57 27 shaped shape VBN en-wikipedia-org-9224 57 28 platelets platelet NNS en-wikipedia-org-9224 57 29 . . . en-wikipedia-org-9224 58 1 Some some DT en-wikipedia-org-9224 58 2 leukocytes leukocyte NNS en-wikipedia-org-9224 58 3 ( ( -LRB- en-wikipedia-org-9224 58 4 white white JJ en-wikipedia-org-9224 58 5 blood blood NN en-wikipedia-org-9224 58 6 cells cell NNS en-wikipedia-org-9224 58 7 ) ) -RRB- en-wikipedia-org-9224 58 8 act act VBP en-wikipedia-org-9224 58 9 like like IN en-wikipedia-org-9224 58 10 independent independent JJ en-wikipedia-org-9224 58 11 , , , en-wikipedia-org-9224 58 12 single single RB en-wikipedia-org-9224 58 13 - - HYPH en-wikipedia-org-9224 58 14 celled celle VBN en-wikipedia-org-9224 58 15 organisms organism NNS en-wikipedia-org-9224 58 16 and and CC en-wikipedia-org-9224 58 17 are be VBP en-wikipedia-org-9224 58 18 the the DT en-wikipedia-org-9224 58 19 second second JJ en-wikipedia-org-9224 58 20 arm arm NN en-wikipedia-org-9224 58 21 of of IN en-wikipedia-org-9224 58 22 the the DT en-wikipedia-org-9224 58 23 innate innate JJ en-wikipedia-org-9224 58 24 immune immune JJ en-wikipedia-org-9224 58 25 system system NN en-wikipedia-org-9224 58 26 . . . en-wikipedia-org-9224 59 1 The the DT en-wikipedia-org-9224 59 2 innate innate JJ en-wikipedia-org-9224 59 3 leukocytes leukocyte NNS en-wikipedia-org-9224 59 4 include include VBP en-wikipedia-org-9224 59 5 the the DT en-wikipedia-org-9224 59 6 " " `` en-wikipedia-org-9224 59 7 professional professional JJ en-wikipedia-org-9224 59 8 " " '' en-wikipedia-org-9224 59 9 phagocytes phagocyte NNS en-wikipedia-org-9224 59 10 ( ( -LRB- en-wikipedia-org-9224 59 11 macrophages macrophage NNS en-wikipedia-org-9224 59 12 , , , en-wikipedia-org-9224 59 13 neutrophils neutrophil NNS en-wikipedia-org-9224 59 14 , , , en-wikipedia-org-9224 59 15 and and CC en-wikipedia-org-9224 59 16 dendritic dendritic JJ en-wikipedia-org-9224 59 17 cells cell NNS en-wikipedia-org-9224 59 18 ) ) -RRB- en-wikipedia-org-9224 59 19 . . . en-wikipedia-org-9224 60 1 These these DT en-wikipedia-org-9224 60 2 cells cell NNS en-wikipedia-org-9224 60 3 identify identify VBP en-wikipedia-org-9224 60 4 and and CC en-wikipedia-org-9224 60 5 eliminate eliminate VB en-wikipedia-org-9224 60 6 pathogens pathogen NNS en-wikipedia-org-9224 60 7 , , , en-wikipedia-org-9224 60 8 either either CC en-wikipedia-org-9224 60 9 by by IN en-wikipedia-org-9224 60 10 attacking attack VBG en-wikipedia-org-9224 60 11 larger large JJR en-wikipedia-org-9224 60 12 pathogens pathogen NNS en-wikipedia-org-9224 60 13 through through IN en-wikipedia-org-9224 60 14 contact contact NN en-wikipedia-org-9224 60 15 or or CC en-wikipedia-org-9224 60 16 by by IN en-wikipedia-org-9224 60 17 engulfing engulfing NNP en-wikipedia-org-9224 60 18 and and CC en-wikipedia-org-9224 60 19 then then RB en-wikipedia-org-9224 60 20 killing kill VBG en-wikipedia-org-9224 60 21 microorganisms microorganism NNS en-wikipedia-org-9224 60 22 . . . en-wikipedia-org-9224 61 1 The the DT en-wikipedia-org-9224 61 2 other other JJ en-wikipedia-org-9224 61 3 cells cell NNS en-wikipedia-org-9224 61 4 involved involve VBN en-wikipedia-org-9224 61 5 in in IN en-wikipedia-org-9224 61 6 the the DT en-wikipedia-org-9224 61 7 innate innate JJ en-wikipedia-org-9224 61 8 response response NN en-wikipedia-org-9224 61 9 include include VBP en-wikipedia-org-9224 61 10 innate innate JJ en-wikipedia-org-9224 61 11 lymphoid lymphoid JJ en-wikipedia-org-9224 61 12 cells cell NNS en-wikipedia-org-9224 61 13 , , , en-wikipedia-org-9224 61 14 mast mast JJ en-wikipedia-org-9224 61 15 cells cell NNS en-wikipedia-org-9224 61 16 , , , en-wikipedia-org-9224 61 17 eosinophils eosinophil NNS en-wikipedia-org-9224 61 18 , , , en-wikipedia-org-9224 61 19 basophils basophil NNS en-wikipedia-org-9224 61 20 , , , en-wikipedia-org-9224 61 21 and and CC en-wikipedia-org-9224 61 22 natural natural JJ en-wikipedia-org-9224 61 23 killer killer NN en-wikipedia-org-9224 61 24 cells cell NNS en-wikipedia-org-9224 61 25 . . . en-wikipedia-org-9224 62 1 [ [ -LRB- en-wikipedia-org-9224 62 2 28 28 CD en-wikipedia-org-9224 62 3 ] ] -RRB- en-wikipedia-org-9224 62 4 Phagocytosis Phagocytosis NNP en-wikipedia-org-9224 62 5 is be VBZ en-wikipedia-org-9224 62 6 an an DT en-wikipedia-org-9224 62 7 important important JJ en-wikipedia-org-9224 62 8 feature feature NN en-wikipedia-org-9224 62 9 of of IN en-wikipedia-org-9224 62 10 cellular cellular JJ en-wikipedia-org-9224 62 11 innate innate NN en-wikipedia-org-9224 62 12 immunity immunity NN en-wikipedia-org-9224 62 13 performed perform VBN en-wikipedia-org-9224 62 14 by by IN en-wikipedia-org-9224 62 15 cells cell NNS en-wikipedia-org-9224 62 16 called call VBN en-wikipedia-org-9224 62 17 phagocytes phagocyte NNS en-wikipedia-org-9224 62 18 that that IN en-wikipedia-org-9224 62 19 engulf engulf NN en-wikipedia-org-9224 62 20 pathogens pathogen VBZ en-wikipedia-org-9224 62 21 or or CC en-wikipedia-org-9224 62 22 particles particle NNS en-wikipedia-org-9224 62 23 . . . en-wikipedia-org-9224 63 1 Phagocytes phagocyte NNS en-wikipedia-org-9224 63 2 generally generally RB en-wikipedia-org-9224 63 3 patrol patrol VBP en-wikipedia-org-9224 63 4 the the DT en-wikipedia-org-9224 63 5 body body NN en-wikipedia-org-9224 63 6 searching search VBG en-wikipedia-org-9224 63 7 for for IN en-wikipedia-org-9224 63 8 pathogens pathogen NNS en-wikipedia-org-9224 63 9 , , , en-wikipedia-org-9224 63 10 but but CC en-wikipedia-org-9224 63 11 can can MD en-wikipedia-org-9224 63 12 be be VB en-wikipedia-org-9224 63 13 called call VBN en-wikipedia-org-9224 63 14 to to IN en-wikipedia-org-9224 63 15 specific specific JJ en-wikipedia-org-9224 63 16 locations location NNS en-wikipedia-org-9224 63 17 by by IN en-wikipedia-org-9224 63 18 cytokines cytokine NNS en-wikipedia-org-9224 63 19 . . . en-wikipedia-org-9224 64 1 [ [ -LRB- en-wikipedia-org-9224 64 2 29 29 CD en-wikipedia-org-9224 64 3 ] ] -RRB- en-wikipedia-org-9224 64 4 Once once RB en-wikipedia-org-9224 64 5 a a DT en-wikipedia-org-9224 64 6 pathogen pathogen NN en-wikipedia-org-9224 64 7 has have VBZ en-wikipedia-org-9224 64 8 been be VBN en-wikipedia-org-9224 64 9 engulfed engulf VBN en-wikipedia-org-9224 64 10 by by IN en-wikipedia-org-9224 64 11 a a DT en-wikipedia-org-9224 64 12 phagocyte phagocyte NN en-wikipedia-org-9224 64 13 , , , en-wikipedia-org-9224 64 14 it -PRON- PRP en-wikipedia-org-9224 64 15 becomes become VBZ en-wikipedia-org-9224 64 16 trapped trap VBN en-wikipedia-org-9224 64 17 in in IN en-wikipedia-org-9224 64 18 an an DT en-wikipedia-org-9224 64 19 intracellular intracellular JJ en-wikipedia-org-9224 64 20 vesicle vesicle NN en-wikipedia-org-9224 64 21 called call VBN en-wikipedia-org-9224 64 22 a a DT en-wikipedia-org-9224 64 23 phagosome phagosome NN en-wikipedia-org-9224 64 24 , , , en-wikipedia-org-9224 64 25 which which WDT en-wikipedia-org-9224 64 26 subsequently subsequently RB en-wikipedia-org-9224 64 27 fuses fuse VBZ en-wikipedia-org-9224 64 28 with with IN en-wikipedia-org-9224 64 29 another another DT en-wikipedia-org-9224 64 30 vesicle vesicle NN en-wikipedia-org-9224 64 31 called call VBN en-wikipedia-org-9224 64 32 a a DT en-wikipedia-org-9224 64 33 lysosome lysosome NN en-wikipedia-org-9224 64 34 to to TO en-wikipedia-org-9224 64 35 form form VB en-wikipedia-org-9224 64 36 a a DT en-wikipedia-org-9224 64 37 phagolysosome phagolysosome NN en-wikipedia-org-9224 64 38 . . . en-wikipedia-org-9224 65 1 The the DT en-wikipedia-org-9224 65 2 pathogen pathogen NN en-wikipedia-org-9224 65 3 is be VBZ en-wikipedia-org-9224 65 4 killed kill VBN en-wikipedia-org-9224 65 5 by by IN en-wikipedia-org-9224 65 6 the the DT en-wikipedia-org-9224 65 7 activity activity NN en-wikipedia-org-9224 65 8 of of IN en-wikipedia-org-9224 65 9 digestive digestive JJ en-wikipedia-org-9224 65 10 enzymes enzyme NNS en-wikipedia-org-9224 65 11 or or CC en-wikipedia-org-9224 65 12 following follow VBG en-wikipedia-org-9224 65 13 a a DT en-wikipedia-org-9224 65 14 respiratory respiratory JJ en-wikipedia-org-9224 65 15 burst burst NN en-wikipedia-org-9224 65 16 that that WDT en-wikipedia-org-9224 65 17 releases release VBZ en-wikipedia-org-9224 65 18 free free JJ en-wikipedia-org-9224 65 19 radicals radical NNS en-wikipedia-org-9224 65 20 into into IN en-wikipedia-org-9224 65 21 the the DT en-wikipedia-org-9224 65 22 phagolysosome phagolysosome NN en-wikipedia-org-9224 65 23 . . . en-wikipedia-org-9224 66 1 [ [ -LRB- en-wikipedia-org-9224 66 2 30][31 30][31 LS en-wikipedia-org-9224 66 3 ] ] -RRB- en-wikipedia-org-9224 66 4 Phagocytosis Phagocytosis NNP en-wikipedia-org-9224 66 5 evolved evolve VBD en-wikipedia-org-9224 66 6 as as IN en-wikipedia-org-9224 66 7 a a DT en-wikipedia-org-9224 66 8 means means NN en-wikipedia-org-9224 66 9 of of IN en-wikipedia-org-9224 66 10 acquiring acquire VBG en-wikipedia-org-9224 66 11 nutrients nutrient NNS en-wikipedia-org-9224 66 12 , , , en-wikipedia-org-9224 66 13 but but CC en-wikipedia-org-9224 66 14 this this DT en-wikipedia-org-9224 66 15 role role NN en-wikipedia-org-9224 66 16 was be VBD en-wikipedia-org-9224 66 17 extended extend VBN en-wikipedia-org-9224 66 18 in in IN en-wikipedia-org-9224 66 19 phagocytes phagocyte NNS en-wikipedia-org-9224 66 20 to to TO en-wikipedia-org-9224 66 21 include include VB en-wikipedia-org-9224 66 22 engulfment engulfment NN en-wikipedia-org-9224 66 23 of of IN en-wikipedia-org-9224 66 24 pathogens pathogens NNP en-wikipedia-org-9224 66 25 as as IN en-wikipedia-org-9224 66 26 a a DT en-wikipedia-org-9224 66 27 defense defense NN en-wikipedia-org-9224 66 28 mechanism mechanism NN en-wikipedia-org-9224 66 29 . . . en-wikipedia-org-9224 67 1 [ [ -LRB- en-wikipedia-org-9224 67 2 32 32 CD en-wikipedia-org-9224 67 3 ] ] -RRB- en-wikipedia-org-9224 67 4 Phagocytosis Phagocytosis NNP en-wikipedia-org-9224 67 5 probably probably RB en-wikipedia-org-9224 67 6 represents represent VBZ en-wikipedia-org-9224 67 7 the the DT en-wikipedia-org-9224 67 8 oldest old JJS en-wikipedia-org-9224 67 9 form form NN en-wikipedia-org-9224 67 10 of of IN en-wikipedia-org-9224 67 11 host host NN en-wikipedia-org-9224 67 12 defense defense NN en-wikipedia-org-9224 67 13 , , , en-wikipedia-org-9224 67 14 as as IN en-wikipedia-org-9224 67 15 phagocytes phagocyte NNS en-wikipedia-org-9224 67 16 have have VBP en-wikipedia-org-9224 67 17 been be VBN en-wikipedia-org-9224 67 18 identified identify VBN en-wikipedia-org-9224 67 19 in in IN en-wikipedia-org-9224 67 20 both both DT en-wikipedia-org-9224 67 21 vertebrate vertebrate NN en-wikipedia-org-9224 67 22 and and CC en-wikipedia-org-9224 67 23 invertebrate invertebrate VBP en-wikipedia-org-9224 67 24 animals animal NNS en-wikipedia-org-9224 67 25 . . . en-wikipedia-org-9224 68 1 [ [ -LRB- en-wikipedia-org-9224 68 2 33 33 CD en-wikipedia-org-9224 68 3 ] ] -RRB- en-wikipedia-org-9224 68 4 Neutrophils neutrophil NNS en-wikipedia-org-9224 68 5 and and CC en-wikipedia-org-9224 68 6 macrophages macrophage NNS en-wikipedia-org-9224 68 7 are be VBP en-wikipedia-org-9224 68 8 phagocytes phagocyte NNS en-wikipedia-org-9224 68 9 that that WDT en-wikipedia-org-9224 68 10 travel travel VBP en-wikipedia-org-9224 68 11 throughout throughout IN en-wikipedia-org-9224 68 12 the the DT en-wikipedia-org-9224 68 13 body body NN en-wikipedia-org-9224 68 14 in in IN en-wikipedia-org-9224 68 15 pursuit pursuit NN en-wikipedia-org-9224 68 16 of of IN en-wikipedia-org-9224 68 17 invading invade VBG en-wikipedia-org-9224 68 18 pathogens pathogen NNS en-wikipedia-org-9224 68 19 . . . en-wikipedia-org-9224 69 1 [ [ -LRB- en-wikipedia-org-9224 69 2 34 34 CD en-wikipedia-org-9224 69 3 ] ] -RRB- en-wikipedia-org-9224 69 4 Neutrophils neutrophil NNS en-wikipedia-org-9224 69 5 are be VBP en-wikipedia-org-9224 69 6 normally normally RB en-wikipedia-org-9224 69 7 found find VBN en-wikipedia-org-9224 69 8 in in IN en-wikipedia-org-9224 69 9 the the DT en-wikipedia-org-9224 69 10 bloodstream bloodstream NN en-wikipedia-org-9224 69 11 and and CC en-wikipedia-org-9224 69 12 are be VBP en-wikipedia-org-9224 69 13 the the DT en-wikipedia-org-9224 69 14 most most RBS en-wikipedia-org-9224 69 15 abundant abundant JJ en-wikipedia-org-9224 69 16 type type NN en-wikipedia-org-9224 69 17 of of IN en-wikipedia-org-9224 69 18 phagocyte phagocyte NNS en-wikipedia-org-9224 69 19 , , , en-wikipedia-org-9224 69 20 representing represent VBG en-wikipedia-org-9224 69 21 50 50 CD en-wikipedia-org-9224 69 22 % % NN en-wikipedia-org-9224 69 23 to to TO en-wikipedia-org-9224 69 24 60 60 CD en-wikipedia-org-9224 69 25 % % NN en-wikipedia-org-9224 69 26 of of IN en-wikipedia-org-9224 69 27 total total JJ en-wikipedia-org-9224 69 28 circulating circulate VBG en-wikipedia-org-9224 69 29 leukocytes leukocyte NNS en-wikipedia-org-9224 69 30 . . . en-wikipedia-org-9224 70 1 [ [ -LRB- en-wikipedia-org-9224 70 2 35 35 CD en-wikipedia-org-9224 70 3 ] ] -RRB- en-wikipedia-org-9224 70 4 During during IN en-wikipedia-org-9224 70 5 the the DT en-wikipedia-org-9224 70 6 acute acute JJ en-wikipedia-org-9224 70 7 phase phase NN en-wikipedia-org-9224 70 8 of of IN en-wikipedia-org-9224 70 9 inflammation inflammation NN en-wikipedia-org-9224 70 10 , , , en-wikipedia-org-9224 70 11 neutrophils neutrophil VBZ en-wikipedia-org-9224 70 12 migrate migrate NNP en-wikipedia-org-9224 70 13 toward toward IN en-wikipedia-org-9224 70 14 the the DT en-wikipedia-org-9224 70 15 site site NN en-wikipedia-org-9224 70 16 of of IN en-wikipedia-org-9224 70 17 inflammation inflammation NN en-wikipedia-org-9224 70 18 in in IN en-wikipedia-org-9224 70 19 a a DT en-wikipedia-org-9224 70 20 process process NN en-wikipedia-org-9224 70 21 called call VBN en-wikipedia-org-9224 70 22 chemotaxis chemotaxis NNP en-wikipedia-org-9224 70 23 , , , en-wikipedia-org-9224 70 24 and and CC en-wikipedia-org-9224 70 25 are be VBP en-wikipedia-org-9224 70 26 usually usually RB en-wikipedia-org-9224 70 27 the the DT en-wikipedia-org-9224 70 28 first first JJ en-wikipedia-org-9224 70 29 cells cell NNS en-wikipedia-org-9224 70 30 to to TO en-wikipedia-org-9224 70 31 arrive arrive VB en-wikipedia-org-9224 70 32 at at IN en-wikipedia-org-9224 70 33 the the DT en-wikipedia-org-9224 70 34 scene scene NN en-wikipedia-org-9224 70 35 of of IN en-wikipedia-org-9224 70 36 infection infection NN en-wikipedia-org-9224 70 37 . . . en-wikipedia-org-9224 71 1 Macrophages macrophage NNS en-wikipedia-org-9224 71 2 are be VBP en-wikipedia-org-9224 71 3 versatile versatile JJ en-wikipedia-org-9224 71 4 cells cell NNS en-wikipedia-org-9224 71 5 that that WDT en-wikipedia-org-9224 71 6 reside reside VBP en-wikipedia-org-9224 71 7 within within IN en-wikipedia-org-9224 71 8 tissues tissue NNS en-wikipedia-org-9224 71 9 and and CC en-wikipedia-org-9224 71 10 produce produce VB en-wikipedia-org-9224 71 11 an an DT en-wikipedia-org-9224 71 12 array array NN en-wikipedia-org-9224 71 13 of of IN en-wikipedia-org-9224 71 14 chemicals chemical NNS en-wikipedia-org-9224 71 15 including include VBG en-wikipedia-org-9224 71 16 enzymes enzyme NNS en-wikipedia-org-9224 71 17 , , , en-wikipedia-org-9224 71 18 complement complement NN en-wikipedia-org-9224 71 19 proteins protein NNS en-wikipedia-org-9224 71 20 , , , en-wikipedia-org-9224 71 21 and and CC en-wikipedia-org-9224 71 22 cytokines cytokine NNS en-wikipedia-org-9224 71 23 , , , en-wikipedia-org-9224 71 24 while while IN en-wikipedia-org-9224 71 25 they -PRON- PRP en-wikipedia-org-9224 71 26 can can MD en-wikipedia-org-9224 71 27 also also RB en-wikipedia-org-9224 71 28 act act VB en-wikipedia-org-9224 71 29 as as IN en-wikipedia-org-9224 71 30 scavengers scavenger NNS en-wikipedia-org-9224 71 31 that that WDT en-wikipedia-org-9224 71 32 rid rid VBD en-wikipedia-org-9224 71 33 the the DT en-wikipedia-org-9224 71 34 body body NN en-wikipedia-org-9224 71 35 of of IN en-wikipedia-org-9224 71 36 worn wear VBN en-wikipedia-org-9224 71 37 - - HYPH en-wikipedia-org-9224 71 38 out out RP en-wikipedia-org-9224 71 39 cells cell NNS en-wikipedia-org-9224 71 40 and and CC en-wikipedia-org-9224 71 41 other other JJ en-wikipedia-org-9224 71 42 debris debris NN en-wikipedia-org-9224 71 43 , , , en-wikipedia-org-9224 71 44 and and CC en-wikipedia-org-9224 71 45 as as IN en-wikipedia-org-9224 71 46 antigen antigen NN en-wikipedia-org-9224 71 47 - - HYPH en-wikipedia-org-9224 71 48 presenting present VBG en-wikipedia-org-9224 71 49 cells cell NNS en-wikipedia-org-9224 71 50 ( ( -LRB- en-wikipedia-org-9224 71 51 APC APC NNP en-wikipedia-org-9224 71 52 ) ) -RRB- en-wikipedia-org-9224 71 53 that that WDT en-wikipedia-org-9224 71 54 activate activate VBP en-wikipedia-org-9224 71 55 the the DT en-wikipedia-org-9224 71 56 adaptive adaptive JJ en-wikipedia-org-9224 71 57 immune immune JJ en-wikipedia-org-9224 71 58 system system NN en-wikipedia-org-9224 71 59 . . . en-wikipedia-org-9224 72 1 [ [ -LRB- en-wikipedia-org-9224 72 2 36 36 CD en-wikipedia-org-9224 72 3 ] ] -RRB- en-wikipedia-org-9224 72 4 Dendritic dendritic JJ en-wikipedia-org-9224 72 5 cells cell NNS en-wikipedia-org-9224 72 6 are be VBP en-wikipedia-org-9224 72 7 phagocytes phagocyte NNS en-wikipedia-org-9224 72 8 in in IN en-wikipedia-org-9224 72 9 tissues tissue NNS en-wikipedia-org-9224 72 10 that that WDT en-wikipedia-org-9224 72 11 are be VBP en-wikipedia-org-9224 72 12 in in IN en-wikipedia-org-9224 72 13 contact contact NN en-wikipedia-org-9224 72 14 with with IN en-wikipedia-org-9224 72 15 the the DT en-wikipedia-org-9224 72 16 external external JJ en-wikipedia-org-9224 72 17 environment environment NN en-wikipedia-org-9224 72 18 ; ; : en-wikipedia-org-9224 72 19 therefore therefore RB en-wikipedia-org-9224 72 20 , , , en-wikipedia-org-9224 72 21 they -PRON- PRP en-wikipedia-org-9224 72 22 are be VBP en-wikipedia-org-9224 72 23 located locate VBN en-wikipedia-org-9224 72 24 mainly mainly RB en-wikipedia-org-9224 72 25 in in IN en-wikipedia-org-9224 72 26 the the DT en-wikipedia-org-9224 72 27 skin skin NN en-wikipedia-org-9224 72 28 , , , en-wikipedia-org-9224 72 29 nose nose NN en-wikipedia-org-9224 72 30 , , , en-wikipedia-org-9224 72 31 lungs lung NNS en-wikipedia-org-9224 72 32 , , , en-wikipedia-org-9224 72 33 stomach stomach NN en-wikipedia-org-9224 72 34 , , , en-wikipedia-org-9224 72 35 and and CC en-wikipedia-org-9224 72 36 intestines intestine NNS en-wikipedia-org-9224 72 37 . . . en-wikipedia-org-9224 73 1 [ [ -LRB- en-wikipedia-org-9224 73 2 37 37 CD en-wikipedia-org-9224 73 3 ] ] -RRB- en-wikipedia-org-9224 73 4 They -PRON- PRP en-wikipedia-org-9224 73 5 are be VBP en-wikipedia-org-9224 73 6 named name VBN en-wikipedia-org-9224 73 7 for for IN en-wikipedia-org-9224 73 8 their -PRON- PRP$ en-wikipedia-org-9224 73 9 resemblance resemblance NN en-wikipedia-org-9224 73 10 to to IN en-wikipedia-org-9224 73 11 neuronal neuronal JJ en-wikipedia-org-9224 73 12 dendrites dendrite NNS en-wikipedia-org-9224 73 13 , , , en-wikipedia-org-9224 73 14 as as IN en-wikipedia-org-9224 73 15 both both DT en-wikipedia-org-9224 73 16 have have VBP en-wikipedia-org-9224 73 17 many many JJ en-wikipedia-org-9224 73 18 spine spine NN en-wikipedia-org-9224 73 19 - - HYPH en-wikipedia-org-9224 73 20 like like JJ en-wikipedia-org-9224 73 21 projections projection NNS en-wikipedia-org-9224 73 22 . . . en-wikipedia-org-9224 74 1 Dendritic dendritic JJ en-wikipedia-org-9224 74 2 cells cell NNS en-wikipedia-org-9224 74 3 serve serve VBP en-wikipedia-org-9224 74 4 as as IN en-wikipedia-org-9224 74 5 a a DT en-wikipedia-org-9224 74 6 link link NN en-wikipedia-org-9224 74 7 between between IN en-wikipedia-org-9224 74 8 the the DT en-wikipedia-org-9224 74 9 bodily bodily JJ en-wikipedia-org-9224 74 10 tissues tissue NNS en-wikipedia-org-9224 74 11 and and CC en-wikipedia-org-9224 74 12 the the DT en-wikipedia-org-9224 74 13 innate innate JJ en-wikipedia-org-9224 74 14 and and CC en-wikipedia-org-9224 74 15 adaptive adaptive JJ en-wikipedia-org-9224 74 16 immune immune JJ en-wikipedia-org-9224 74 17 systems system NNS en-wikipedia-org-9224 74 18 , , , en-wikipedia-org-9224 74 19 as as IN en-wikipedia-org-9224 74 20 they -PRON- PRP en-wikipedia-org-9224 74 21 present present VBP en-wikipedia-org-9224 74 22 antigens antigen NNS en-wikipedia-org-9224 74 23 to to IN en-wikipedia-org-9224 74 24 T t NN en-wikipedia-org-9224 74 25 cells cell NNS en-wikipedia-org-9224 74 26 , , , en-wikipedia-org-9224 74 27 one one CD en-wikipedia-org-9224 74 28 of of IN en-wikipedia-org-9224 74 29 the the DT en-wikipedia-org-9224 74 30 key key JJ en-wikipedia-org-9224 74 31 cell cell NN en-wikipedia-org-9224 74 32 types type NNS en-wikipedia-org-9224 74 33 of of IN en-wikipedia-org-9224 74 34 the the DT en-wikipedia-org-9224 74 35 adaptive adaptive JJ en-wikipedia-org-9224 74 36 immune immune JJ en-wikipedia-org-9224 74 37 system system NN en-wikipedia-org-9224 74 38 . . . en-wikipedia-org-9224 75 1 [ [ -LRB- en-wikipedia-org-9224 75 2 37 37 CD en-wikipedia-org-9224 75 3 ] ] -RRB- en-wikipedia-org-9224 75 4 Granulocytes Granulocytes NNPS en-wikipedia-org-9224 75 5 are be VBP en-wikipedia-org-9224 75 6 leukocytes leukocyte NNS en-wikipedia-org-9224 75 7 that that WDT en-wikipedia-org-9224 75 8 have have VBP en-wikipedia-org-9224 75 9 granules granule NNS en-wikipedia-org-9224 75 10 in in IN en-wikipedia-org-9224 75 11 their -PRON- PRP$ en-wikipedia-org-9224 75 12 cytoplasm cytoplasm NN en-wikipedia-org-9224 75 13 . . . en-wikipedia-org-9224 76 1 In in IN en-wikipedia-org-9224 76 2 this this DT en-wikipedia-org-9224 76 3 category category NN en-wikipedia-org-9224 76 4 are be VBP en-wikipedia-org-9224 76 5 neutrophils neutrophil NNS en-wikipedia-org-9224 76 6 , , , en-wikipedia-org-9224 76 7 mast mast JJ en-wikipedia-org-9224 76 8 cells cell NNS en-wikipedia-org-9224 76 9 , , , en-wikipedia-org-9224 76 10 basophils basophil NNS en-wikipedia-org-9224 76 11 , , , en-wikipedia-org-9224 76 12 and and CC en-wikipedia-org-9224 76 13 eosinophils eosinophil NNS en-wikipedia-org-9224 76 14 . . . en-wikipedia-org-9224 77 1 Mast mast JJ en-wikipedia-org-9224 77 2 cells cell NNS en-wikipedia-org-9224 77 3 reside reside VBP en-wikipedia-org-9224 77 4 in in IN en-wikipedia-org-9224 77 5 connective connective JJ en-wikipedia-org-9224 77 6 tissues tissue NNS en-wikipedia-org-9224 77 7 and and CC en-wikipedia-org-9224 77 8 mucous mucous JJ en-wikipedia-org-9224 77 9 membranes membrane NNS en-wikipedia-org-9224 77 10 , , , en-wikipedia-org-9224 77 11 and and CC en-wikipedia-org-9224 77 12 regulate regulate VB en-wikipedia-org-9224 77 13 the the DT en-wikipedia-org-9224 77 14 inflammatory inflammatory JJ en-wikipedia-org-9224 77 15 response response NN en-wikipedia-org-9224 77 16 . . . en-wikipedia-org-9224 78 1 [ [ -LRB- en-wikipedia-org-9224 78 2 38 38 CD en-wikipedia-org-9224 78 3 ] ] -RRB- en-wikipedia-org-9224 78 4 They -PRON- PRP en-wikipedia-org-9224 78 5 are be VBP en-wikipedia-org-9224 78 6 most most RBS en-wikipedia-org-9224 78 7 often often RB en-wikipedia-org-9224 78 8 associated associate VBN en-wikipedia-org-9224 78 9 with with IN en-wikipedia-org-9224 78 10 allergy allergy NN en-wikipedia-org-9224 78 11 and and CC en-wikipedia-org-9224 78 12 anaphylaxis anaphylaxi NNS en-wikipedia-org-9224 78 13 . . . en-wikipedia-org-9224 79 1 [ [ -LRB- en-wikipedia-org-9224 79 2 35 35 CD en-wikipedia-org-9224 79 3 ] ] -RRB- en-wikipedia-org-9224 79 4 Basophils basophil NNS en-wikipedia-org-9224 79 5 and and CC en-wikipedia-org-9224 79 6 eosinophils eosinophil NNS en-wikipedia-org-9224 79 7 are be VBP en-wikipedia-org-9224 79 8 related relate VBN en-wikipedia-org-9224 79 9 to to IN en-wikipedia-org-9224 79 10 neutrophils neutrophil NNS en-wikipedia-org-9224 79 11 . . . en-wikipedia-org-9224 80 1 They -PRON- PRP en-wikipedia-org-9224 80 2 secrete secrete VBP en-wikipedia-org-9224 80 3 chemical chemical NN en-wikipedia-org-9224 80 4 mediators mediator NNS en-wikipedia-org-9224 80 5 that that WDT en-wikipedia-org-9224 80 6 are be VBP en-wikipedia-org-9224 80 7 involved involve VBN en-wikipedia-org-9224 80 8 in in IN en-wikipedia-org-9224 80 9 defending defend VBG en-wikipedia-org-9224 80 10 against against IN en-wikipedia-org-9224 80 11 parasites parasite NNS en-wikipedia-org-9224 80 12 and and CC en-wikipedia-org-9224 80 13 play play VB en-wikipedia-org-9224 80 14 a a DT en-wikipedia-org-9224 80 15 role role NN en-wikipedia-org-9224 80 16 in in IN en-wikipedia-org-9224 80 17 allergic allergic JJ en-wikipedia-org-9224 80 18 reactions reaction NNS en-wikipedia-org-9224 80 19 , , , en-wikipedia-org-9224 80 20 such such JJ en-wikipedia-org-9224 80 21 as as IN en-wikipedia-org-9224 80 22 asthma asthma NN en-wikipedia-org-9224 80 23 . . . en-wikipedia-org-9224 81 1 [ [ -LRB- en-wikipedia-org-9224 81 2 39 39 CD en-wikipedia-org-9224 81 3 ] ] -RRB- en-wikipedia-org-9224 81 4 Innate innate VB en-wikipedia-org-9224 81 5 lymphoid lymphoid JJ en-wikipedia-org-9224 81 6 cells cell NNS en-wikipedia-org-9224 81 7 ( ( -LRB- en-wikipedia-org-9224 81 8 ILCs ILCs NNP en-wikipedia-org-9224 81 9 ) ) -RRB- en-wikipedia-org-9224 81 10 are be VBP en-wikipedia-org-9224 81 11 a a DT en-wikipedia-org-9224 81 12 group group NN en-wikipedia-org-9224 81 13 of of IN en-wikipedia-org-9224 81 14 innate innate JJ en-wikipedia-org-9224 81 15 immune immune JJ en-wikipedia-org-9224 81 16 cells cell NNS en-wikipedia-org-9224 81 17 that that WDT en-wikipedia-org-9224 81 18 are be VBP en-wikipedia-org-9224 81 19 derived derive VBN en-wikipedia-org-9224 81 20 from from IN en-wikipedia-org-9224 81 21 common common JJ en-wikipedia-org-9224 81 22 lymphoid lymphoid JJ en-wikipedia-org-9224 81 23 progenitor progenitor NN en-wikipedia-org-9224 81 24 and and CC en-wikipedia-org-9224 81 25 belong belong VB en-wikipedia-org-9224 81 26 to to IN en-wikipedia-org-9224 81 27 the the DT en-wikipedia-org-9224 81 28 lymphoid lymphoid JJ en-wikipedia-org-9224 81 29 lineage lineage NN en-wikipedia-org-9224 81 30 . . . en-wikipedia-org-9224 82 1 These these DT en-wikipedia-org-9224 82 2 cells cell NNS en-wikipedia-org-9224 82 3 are be VBP en-wikipedia-org-9224 82 4 defined define VBN en-wikipedia-org-9224 82 5 by by IN en-wikipedia-org-9224 82 6 absence absence NN en-wikipedia-org-9224 82 7 of of IN en-wikipedia-org-9224 82 8 antigen antigen NNP en-wikipedia-org-9224 82 9 specific specific JJ en-wikipedia-org-9224 82 10 B B NNP en-wikipedia-org-9224 82 11 or or CC en-wikipedia-org-9224 82 12 T T NNP en-wikipedia-org-9224 82 13 cell cell NN en-wikipedia-org-9224 82 14 receptor receptor NN en-wikipedia-org-9224 82 15 ( ( -LRB- en-wikipedia-org-9224 82 16 TCR TCR NNP en-wikipedia-org-9224 82 17 ) ) -RRB- en-wikipedia-org-9224 82 18 because because IN en-wikipedia-org-9224 82 19 of of IN en-wikipedia-org-9224 82 20 the the DT en-wikipedia-org-9224 82 21 lack lack NN en-wikipedia-org-9224 82 22 of of IN en-wikipedia-org-9224 82 23 recombination recombination NN en-wikipedia-org-9224 82 24 activating activate VBG en-wikipedia-org-9224 82 25 gene gene NN en-wikipedia-org-9224 82 26 . . . en-wikipedia-org-9224 83 1 ILCs ilc NNS en-wikipedia-org-9224 83 2 do do VBP en-wikipedia-org-9224 83 3 not not RB en-wikipedia-org-9224 83 4 express express VB en-wikipedia-org-9224 83 5 myeloid myeloid NN en-wikipedia-org-9224 83 6 or or CC en-wikipedia-org-9224 83 7 dendritic dendritic JJ en-wikipedia-org-9224 83 8 cell cell NN en-wikipedia-org-9224 83 9 markers marker NNS en-wikipedia-org-9224 83 10 . . . en-wikipedia-org-9224 84 1 [ [ -LRB- en-wikipedia-org-9224 84 2 40 40 CD en-wikipedia-org-9224 84 3 ] ] -RRB- en-wikipedia-org-9224 84 4 Natural natural JJ en-wikipedia-org-9224 84 5 killer killer NN en-wikipedia-org-9224 84 6 cells cell NNS en-wikipedia-org-9224 84 7 ( ( -LRB- en-wikipedia-org-9224 84 8 NK NK NNP en-wikipedia-org-9224 84 9 ) ) -RRB- en-wikipedia-org-9224 84 10 are be VBP en-wikipedia-org-9224 84 11 lymphocytes lymphocyte NNS en-wikipedia-org-9224 84 12 and and CC en-wikipedia-org-9224 84 13 a a DT en-wikipedia-org-9224 84 14 component component NN en-wikipedia-org-9224 84 15 of of IN en-wikipedia-org-9224 84 16 the the DT en-wikipedia-org-9224 84 17 innate innate JJ en-wikipedia-org-9224 84 18 immune immune JJ en-wikipedia-org-9224 84 19 system system NN en-wikipedia-org-9224 84 20 which which WDT en-wikipedia-org-9224 84 21 does do VBZ en-wikipedia-org-9224 84 22 not not RB en-wikipedia-org-9224 84 23 directly directly RB en-wikipedia-org-9224 84 24 attack attack VB en-wikipedia-org-9224 84 25 invading invade VBG en-wikipedia-org-9224 84 26 microbes microbe NNS en-wikipedia-org-9224 84 27 . . . en-wikipedia-org-9224 85 1 [ [ -LRB- en-wikipedia-org-9224 85 2 41 41 CD en-wikipedia-org-9224 85 3 ] ] -RRB- en-wikipedia-org-9224 85 4 Rather rather RB en-wikipedia-org-9224 85 5 , , , en-wikipedia-org-9224 85 6 NK NK NNP en-wikipedia-org-9224 85 7 cells cell NNS en-wikipedia-org-9224 85 8 destroy destroy VBP en-wikipedia-org-9224 85 9 compromised compromised JJ en-wikipedia-org-9224 85 10 host host NN en-wikipedia-org-9224 85 11 cells cell NNS en-wikipedia-org-9224 85 12 , , , en-wikipedia-org-9224 85 13 such such JJ en-wikipedia-org-9224 85 14 as as IN en-wikipedia-org-9224 85 15 tumor tumor NN en-wikipedia-org-9224 85 16 cells cell NNS en-wikipedia-org-9224 85 17 or or CC en-wikipedia-org-9224 85 18 virus virus NN en-wikipedia-org-9224 85 19 - - HYPH en-wikipedia-org-9224 85 20 infected infect VBN en-wikipedia-org-9224 85 21 cells cell NNS en-wikipedia-org-9224 85 22 , , , en-wikipedia-org-9224 85 23 recognizing recognize VBG en-wikipedia-org-9224 85 24 such such JJ en-wikipedia-org-9224 85 25 cells cell NNS en-wikipedia-org-9224 85 26 by by IN en-wikipedia-org-9224 85 27 a a DT en-wikipedia-org-9224 85 28 condition condition NN en-wikipedia-org-9224 85 29 known know VBN en-wikipedia-org-9224 85 30 as as IN en-wikipedia-org-9224 85 31 " " `` en-wikipedia-org-9224 85 32 missing miss VBG en-wikipedia-org-9224 85 33 self self NN en-wikipedia-org-9224 85 34 . . . en-wikipedia-org-9224 85 35 " " '' en-wikipedia-org-9224 86 1 This this DT en-wikipedia-org-9224 86 2 term term NN en-wikipedia-org-9224 86 3 describes describe VBZ en-wikipedia-org-9224 86 4 cells cell NNS en-wikipedia-org-9224 86 5 with with IN en-wikipedia-org-9224 86 6 low low JJ en-wikipedia-org-9224 86 7 levels level NNS en-wikipedia-org-9224 86 8 of of IN en-wikipedia-org-9224 86 9 a a DT en-wikipedia-org-9224 86 10 cell cell NN en-wikipedia-org-9224 86 11 - - HYPH en-wikipedia-org-9224 86 12 surface surface NN en-wikipedia-org-9224 86 13 marker marker NN en-wikipedia-org-9224 86 14 called call VBN en-wikipedia-org-9224 86 15 MHC MHC NNP en-wikipedia-org-9224 86 16 I -PRON- PRP en-wikipedia-org-9224 86 17 ( ( -LRB- en-wikipedia-org-9224 86 18 major major JJ en-wikipedia-org-9224 86 19 histocompatibility histocompatibility NN en-wikipedia-org-9224 86 20 complex)—a complex)—a NN en-wikipedia-org-9224 86 21 situation situation NN en-wikipedia-org-9224 86 22 that that WDT en-wikipedia-org-9224 86 23 can can MD en-wikipedia-org-9224 86 24 arise arise VB en-wikipedia-org-9224 86 25 in in IN en-wikipedia-org-9224 86 26 viral viral JJ en-wikipedia-org-9224 86 27 infections infection NNS en-wikipedia-org-9224 86 28 of of IN en-wikipedia-org-9224 86 29 host host NN en-wikipedia-org-9224 86 30 cells cell NNS en-wikipedia-org-9224 86 31 . . . en-wikipedia-org-9224 87 1 [ [ -LRB- en-wikipedia-org-9224 87 2 42 42 CD en-wikipedia-org-9224 87 3 ] ] -RRB- en-wikipedia-org-9224 87 4 Normal normal JJ en-wikipedia-org-9224 87 5 body body NN en-wikipedia-org-9224 87 6 cells cell NNS en-wikipedia-org-9224 87 7 are be VBP en-wikipedia-org-9224 87 8 not not RB en-wikipedia-org-9224 87 9 recognized recognize VBN en-wikipedia-org-9224 87 10 and and CC en-wikipedia-org-9224 87 11 attacked attack VBN en-wikipedia-org-9224 87 12 by by IN en-wikipedia-org-9224 87 13 NK NK NNP en-wikipedia-org-9224 87 14 cells cell NNS en-wikipedia-org-9224 87 15 because because IN en-wikipedia-org-9224 87 16 they -PRON- PRP en-wikipedia-org-9224 87 17 express express VBP en-wikipedia-org-9224 87 18 intact intact JJ en-wikipedia-org-9224 87 19 self self NN en-wikipedia-org-9224 87 20 MHC MHC NNP en-wikipedia-org-9224 87 21 antigens antigen VBZ en-wikipedia-org-9224 87 22 . . . en-wikipedia-org-9224 88 1 Those those DT en-wikipedia-org-9224 88 2 MHC MHC NNP en-wikipedia-org-9224 88 3 antigens antigen NNS en-wikipedia-org-9224 88 4 are be VBP en-wikipedia-org-9224 88 5 recognized recognize VBN en-wikipedia-org-9224 88 6 by by IN en-wikipedia-org-9224 88 7 killer killer NN en-wikipedia-org-9224 88 8 cell cell NNP en-wikipedia-org-9224 88 9 immunoglobulin immunoglobulin NNP en-wikipedia-org-9224 88 10 receptors receptor NNS en-wikipedia-org-9224 88 11 which which WDT en-wikipedia-org-9224 88 12 essentially essentially RB en-wikipedia-org-9224 88 13 put put VBD en-wikipedia-org-9224 88 14 the the DT en-wikipedia-org-9224 88 15 brakes brake NNS en-wikipedia-org-9224 88 16 on on IN en-wikipedia-org-9224 88 17 NK NK NNP en-wikipedia-org-9224 88 18 cells cell NNS en-wikipedia-org-9224 88 19 . . . en-wikipedia-org-9224 89 1 [ [ -LRB- en-wikipedia-org-9224 89 2 43 43 CD en-wikipedia-org-9224 89 3 ] ] -RRB- en-wikipedia-org-9224 89 4 Inflammation[edit inflammation[edit VB en-wikipedia-org-9224 89 5 ] ] -RRB- en-wikipedia-org-9224 89 6 Further further JJ en-wikipedia-org-9224 89 7 information information NN en-wikipedia-org-9224 89 8 : : : en-wikipedia-org-9224 89 9 Inflammation inflammation NN en-wikipedia-org-9224 89 10 Inflammation Inflammation NNP en-wikipedia-org-9224 89 11 is be VBZ en-wikipedia-org-9224 89 12 one one CD en-wikipedia-org-9224 89 13 of of IN en-wikipedia-org-9224 89 14 the the DT en-wikipedia-org-9224 89 15 first first JJ en-wikipedia-org-9224 89 16 responses response NNS en-wikipedia-org-9224 89 17 of of IN en-wikipedia-org-9224 89 18 the the DT en-wikipedia-org-9224 89 19 immune immune JJ en-wikipedia-org-9224 89 20 system system NN en-wikipedia-org-9224 89 21 to to IN en-wikipedia-org-9224 89 22 infection infection NN en-wikipedia-org-9224 89 23 . . . en-wikipedia-org-9224 90 1 [ [ -LRB- en-wikipedia-org-9224 90 2 44 44 CD en-wikipedia-org-9224 90 3 ] ] -RRB- en-wikipedia-org-9224 90 4 The the DT en-wikipedia-org-9224 90 5 symptoms symptom NNS en-wikipedia-org-9224 90 6 of of IN en-wikipedia-org-9224 90 7 inflammation inflammation NN en-wikipedia-org-9224 90 8 are be VBP en-wikipedia-org-9224 90 9 redness redness JJ en-wikipedia-org-9224 90 10 , , , en-wikipedia-org-9224 90 11 swelling swelling NN en-wikipedia-org-9224 90 12 , , , en-wikipedia-org-9224 90 13 heat heat NN en-wikipedia-org-9224 90 14 , , , en-wikipedia-org-9224 90 15 and and CC en-wikipedia-org-9224 90 16 pain pain NN en-wikipedia-org-9224 90 17 , , , en-wikipedia-org-9224 90 18 which which WDT en-wikipedia-org-9224 90 19 are be VBP en-wikipedia-org-9224 90 20 caused cause VBN en-wikipedia-org-9224 90 21 by by IN en-wikipedia-org-9224 90 22 increased increase VBN en-wikipedia-org-9224 90 23 blood blood NN en-wikipedia-org-9224 90 24 flow flow NN en-wikipedia-org-9224 90 25 into into IN en-wikipedia-org-9224 90 26 tissue tissue NN en-wikipedia-org-9224 90 27 . . . en-wikipedia-org-9224 91 1 Inflammation inflammation NN en-wikipedia-org-9224 91 2 is be VBZ en-wikipedia-org-9224 91 3 produced produce VBN en-wikipedia-org-9224 91 4 by by IN en-wikipedia-org-9224 91 5 eicosanoids eicosanoid NNS en-wikipedia-org-9224 91 6 and and CC en-wikipedia-org-9224 91 7 cytokines cytokine NNS en-wikipedia-org-9224 91 8 , , , en-wikipedia-org-9224 91 9 which which WDT en-wikipedia-org-9224 91 10 are be VBP en-wikipedia-org-9224 91 11 released release VBN en-wikipedia-org-9224 91 12 by by IN en-wikipedia-org-9224 91 13 injured injured JJ en-wikipedia-org-9224 91 14 or or CC en-wikipedia-org-9224 91 15 infected infected JJ en-wikipedia-org-9224 91 16 cells cell NNS en-wikipedia-org-9224 91 17 . . . en-wikipedia-org-9224 92 1 Eicosanoids eicosanoid NNS en-wikipedia-org-9224 92 2 include include VBP en-wikipedia-org-9224 92 3 prostaglandins prostaglandin NNS en-wikipedia-org-9224 92 4 that that WDT en-wikipedia-org-9224 92 5 produce produce VBP en-wikipedia-org-9224 92 6 fever fever NN en-wikipedia-org-9224 92 7 and and CC en-wikipedia-org-9224 92 8 the the DT en-wikipedia-org-9224 92 9 dilation dilation NN en-wikipedia-org-9224 92 10 of of IN en-wikipedia-org-9224 92 11 blood blood NN en-wikipedia-org-9224 92 12 vessels vessel NNS en-wikipedia-org-9224 92 13 associated associate VBN en-wikipedia-org-9224 92 14 with with IN en-wikipedia-org-9224 92 15 inflammation inflammation NN en-wikipedia-org-9224 92 16 , , , en-wikipedia-org-9224 92 17 and and CC en-wikipedia-org-9224 92 18 leukotrienes leukotriene NNS en-wikipedia-org-9224 92 19 that that WDT en-wikipedia-org-9224 92 20 attract attract VBP en-wikipedia-org-9224 92 21 certain certain JJ en-wikipedia-org-9224 92 22 white white JJ en-wikipedia-org-9224 92 23 blood blood NN en-wikipedia-org-9224 92 24 cells cell NNS en-wikipedia-org-9224 92 25 ( ( -LRB- en-wikipedia-org-9224 92 26 leukocytes leukocyte NNS en-wikipedia-org-9224 92 27 ) ) -RRB- en-wikipedia-org-9224 92 28 . . . en-wikipedia-org-9224 93 1 [ [ -LRB- en-wikipedia-org-9224 93 2 45][46 45][46 LS en-wikipedia-org-9224 93 3 ] ] -RRB- en-wikipedia-org-9224 93 4 Common common JJ en-wikipedia-org-9224 93 5 cytokines cytokine NNS en-wikipedia-org-9224 93 6 include include VBP en-wikipedia-org-9224 93 7 interleukins interleukin NNS en-wikipedia-org-9224 93 8 that that WDT en-wikipedia-org-9224 93 9 are be VBP en-wikipedia-org-9224 93 10 responsible responsible JJ en-wikipedia-org-9224 93 11 for for IN en-wikipedia-org-9224 93 12 communication communication NN en-wikipedia-org-9224 93 13 between between IN en-wikipedia-org-9224 93 14 white white JJ en-wikipedia-org-9224 93 15 blood blood NN en-wikipedia-org-9224 93 16 cells cell NNS en-wikipedia-org-9224 93 17 ; ; , en-wikipedia-org-9224 93 18 chemokines chemokine VBZ en-wikipedia-org-9224 93 19 that that WDT en-wikipedia-org-9224 93 20 promote promote VBP en-wikipedia-org-9224 93 21 chemotaxis chemotaxi NNS en-wikipedia-org-9224 93 22 ; ; : en-wikipedia-org-9224 93 23 and and CC en-wikipedia-org-9224 93 24 interferons interferon NNS en-wikipedia-org-9224 93 25 that that WDT en-wikipedia-org-9224 93 26 have have VBP en-wikipedia-org-9224 93 27 anti anti JJ en-wikipedia-org-9224 93 28 - - JJ en-wikipedia-org-9224 93 29 viral viral JJ en-wikipedia-org-9224 93 30 effects effect NNS en-wikipedia-org-9224 93 31 , , , en-wikipedia-org-9224 93 32 such such JJ en-wikipedia-org-9224 93 33 as as IN en-wikipedia-org-9224 93 34 shutting shut VBG en-wikipedia-org-9224 93 35 down down RP en-wikipedia-org-9224 93 36 protein protein NN en-wikipedia-org-9224 93 37 synthesis synthesis NN en-wikipedia-org-9224 93 38 in in IN en-wikipedia-org-9224 93 39 the the DT en-wikipedia-org-9224 93 40 host host NN en-wikipedia-org-9224 93 41 cell cell NN en-wikipedia-org-9224 93 42 . . . en-wikipedia-org-9224 94 1 [ [ -LRB- en-wikipedia-org-9224 94 2 47 47 CD en-wikipedia-org-9224 94 3 ] ] -RRB- en-wikipedia-org-9224 94 4 Growth growth NN en-wikipedia-org-9224 94 5 factors factor NNS en-wikipedia-org-9224 94 6 and and CC en-wikipedia-org-9224 94 7 cytotoxic cytotoxic NN en-wikipedia-org-9224 94 8 factors factor NNS en-wikipedia-org-9224 94 9 may may MD en-wikipedia-org-9224 94 10 also also RB en-wikipedia-org-9224 94 11 be be VB en-wikipedia-org-9224 94 12 released release VBN en-wikipedia-org-9224 94 13 . . . en-wikipedia-org-9224 95 1 These these DT en-wikipedia-org-9224 95 2 cytokines cytokine NNS en-wikipedia-org-9224 95 3 and and CC en-wikipedia-org-9224 95 4 other other JJ en-wikipedia-org-9224 95 5 chemicals chemical NNS en-wikipedia-org-9224 95 6 recruit recruit VBP en-wikipedia-org-9224 95 7 immune immune JJ en-wikipedia-org-9224 95 8 cells cell NNS en-wikipedia-org-9224 95 9 to to IN en-wikipedia-org-9224 95 10 the the DT en-wikipedia-org-9224 95 11 site site NN en-wikipedia-org-9224 95 12 of of IN en-wikipedia-org-9224 95 13 infection infection NN en-wikipedia-org-9224 95 14 and and CC en-wikipedia-org-9224 95 15 promote promote VB en-wikipedia-org-9224 95 16 healing healing NN en-wikipedia-org-9224 95 17 of of IN en-wikipedia-org-9224 95 18 any any DT en-wikipedia-org-9224 95 19 damaged damaged JJ en-wikipedia-org-9224 95 20 tissue tissue NN en-wikipedia-org-9224 95 21 following follow VBG en-wikipedia-org-9224 95 22 the the DT en-wikipedia-org-9224 95 23 removal removal NN en-wikipedia-org-9224 95 24 of of IN en-wikipedia-org-9224 95 25 pathogens pathogen NNS en-wikipedia-org-9224 95 26 . . . en-wikipedia-org-9224 96 1 [ [ -LRB- en-wikipedia-org-9224 96 2 48 48 CD en-wikipedia-org-9224 96 3 ] ] -RRB- en-wikipedia-org-9224 96 4 The the DT en-wikipedia-org-9224 96 5 pattern pattern NN en-wikipedia-org-9224 96 6 - - HYPH en-wikipedia-org-9224 96 7 recognition recognition NN en-wikipedia-org-9224 96 8 receptors receptor NNS en-wikipedia-org-9224 96 9 called call VBN en-wikipedia-org-9224 96 10 inflammasomes inflammasome NNS en-wikipedia-org-9224 96 11 are be VBP en-wikipedia-org-9224 96 12 multiprotein multiprotein NNP en-wikipedia-org-9224 96 13 complexes complex NNS en-wikipedia-org-9224 96 14 ( ( -LRB- en-wikipedia-org-9224 96 15 consisting consist VBG en-wikipedia-org-9224 96 16 of of IN en-wikipedia-org-9224 96 17 an an DT en-wikipedia-org-9224 96 18 NLR NLR NNP en-wikipedia-org-9224 96 19 , , , en-wikipedia-org-9224 96 20 the the DT en-wikipedia-org-9224 96 21 adaptor adaptor NN en-wikipedia-org-9224 96 22 protein protein NN en-wikipedia-org-9224 96 23 ASC ASC NNP en-wikipedia-org-9224 96 24 , , , en-wikipedia-org-9224 96 25 and and CC en-wikipedia-org-9224 96 26 the the DT en-wikipedia-org-9224 96 27 effector effector NN en-wikipedia-org-9224 96 28 molecule molecule VBP en-wikipedia-org-9224 96 29 pro pro JJ en-wikipedia-org-9224 96 30 - - JJ en-wikipedia-org-9224 96 31 caspase-1 caspase-1 NNP en-wikipedia-org-9224 96 32 ) ) -RRB- en-wikipedia-org-9224 96 33 that that WDT en-wikipedia-org-9224 96 34 form form VBP en-wikipedia-org-9224 96 35 in in IN en-wikipedia-org-9224 96 36 response response NN en-wikipedia-org-9224 96 37 to to IN en-wikipedia-org-9224 96 38 cytosolic cytosolic NNP en-wikipedia-org-9224 96 39 PAMPs PAMPs NNP en-wikipedia-org-9224 96 40 and and CC en-wikipedia-org-9224 96 41 DAMPs DAMPs NNP en-wikipedia-org-9224 96 42 , , , en-wikipedia-org-9224 96 43 whose whose WP$ en-wikipedia-org-9224 96 44 function function NN en-wikipedia-org-9224 96 45 is be VBZ en-wikipedia-org-9224 96 46 to to TO en-wikipedia-org-9224 96 47 generate generate VB en-wikipedia-org-9224 96 48 active active JJ en-wikipedia-org-9224 96 49 forms form NNS en-wikipedia-org-9224 96 50 of of IN en-wikipedia-org-9224 96 51 the the DT en-wikipedia-org-9224 96 52 inflammatory inflammatory JJ en-wikipedia-org-9224 96 53 cytokines cytokine NNS en-wikipedia-org-9224 96 54 IL-1β IL-1β NNP en-wikipedia-org-9224 96 55 and and CC en-wikipedia-org-9224 96 56 IL-18 IL-18 NNP en-wikipedia-org-9224 96 57 . . . en-wikipedia-org-9224 97 1 [ [ -LRB- en-wikipedia-org-9224 97 2 49 49 CD en-wikipedia-org-9224 97 3 ] ] -RRB- en-wikipedia-org-9224 97 4 Humoral Humoral NNP en-wikipedia-org-9224 97 5 defenses[edit defenses[edit , en-wikipedia-org-9224 97 6 ] ] -RRB- en-wikipedia-org-9224 97 7 The the DT en-wikipedia-org-9224 97 8 complement complement NN en-wikipedia-org-9224 97 9 system system NN en-wikipedia-org-9224 97 10 is be VBZ en-wikipedia-org-9224 97 11 a a DT en-wikipedia-org-9224 97 12 biochemical biochemical JJ en-wikipedia-org-9224 97 13 cascade cascade NN en-wikipedia-org-9224 97 14 that that WDT en-wikipedia-org-9224 97 15 attacks attack VBZ en-wikipedia-org-9224 97 16 the the DT en-wikipedia-org-9224 97 17 surfaces surface NNS en-wikipedia-org-9224 97 18 of of IN en-wikipedia-org-9224 97 19 foreign foreign JJ en-wikipedia-org-9224 97 20 cells cell NNS en-wikipedia-org-9224 97 21 . . . en-wikipedia-org-9224 98 1 It -PRON- PRP en-wikipedia-org-9224 98 2 contains contain VBZ en-wikipedia-org-9224 98 3 over over IN en-wikipedia-org-9224 98 4 20 20 CD en-wikipedia-org-9224 98 5 different different JJ en-wikipedia-org-9224 98 6 proteins protein NNS en-wikipedia-org-9224 98 7 and and CC en-wikipedia-org-9224 98 8 is be VBZ en-wikipedia-org-9224 98 9 named name VBN en-wikipedia-org-9224 98 10 for for IN en-wikipedia-org-9224 98 11 its -PRON- PRP$ en-wikipedia-org-9224 98 12 ability ability NN en-wikipedia-org-9224 98 13 to to TO en-wikipedia-org-9224 98 14 " " `` en-wikipedia-org-9224 98 15 complement complement VB en-wikipedia-org-9224 98 16 " " '' en-wikipedia-org-9224 98 17 the the DT en-wikipedia-org-9224 98 18 killing killing NN en-wikipedia-org-9224 98 19 of of IN en-wikipedia-org-9224 98 20 pathogens pathogen NNS en-wikipedia-org-9224 98 21 by by IN en-wikipedia-org-9224 98 22 antibodies antibody NNS en-wikipedia-org-9224 98 23 . . . en-wikipedia-org-9224 99 1 Complement Complement NNP en-wikipedia-org-9224 99 2 is be VBZ en-wikipedia-org-9224 99 3 the the DT en-wikipedia-org-9224 99 4 major major JJ en-wikipedia-org-9224 99 5 humoral humoral JJ en-wikipedia-org-9224 99 6 component component NN en-wikipedia-org-9224 99 7 of of IN en-wikipedia-org-9224 99 8 the the DT en-wikipedia-org-9224 99 9 innate innate JJ en-wikipedia-org-9224 99 10 immune immune JJ en-wikipedia-org-9224 99 11 response response NN en-wikipedia-org-9224 99 12 . . . en-wikipedia-org-9224 100 1 [ [ -LRB- en-wikipedia-org-9224 100 2 50][51 50][51 LS en-wikipedia-org-9224 100 3 ] ] -RRB- en-wikipedia-org-9224 100 4 Many many JJ en-wikipedia-org-9224 100 5 species specie NNS en-wikipedia-org-9224 100 6 have have VBP en-wikipedia-org-9224 100 7 complement complement JJ en-wikipedia-org-9224 100 8 systems system NNS en-wikipedia-org-9224 100 9 , , , en-wikipedia-org-9224 100 10 including include VBG en-wikipedia-org-9224 100 11 non non NNS en-wikipedia-org-9224 100 12 - - NNS en-wikipedia-org-9224 100 13 mammals mammal NNS en-wikipedia-org-9224 100 14 like like IN en-wikipedia-org-9224 100 15 plants plant NNS en-wikipedia-org-9224 100 16 , , , en-wikipedia-org-9224 100 17 fish fish NNS en-wikipedia-org-9224 100 18 , , , en-wikipedia-org-9224 100 19 and and CC en-wikipedia-org-9224 100 20 some some DT en-wikipedia-org-9224 100 21 invertebrates invertebrates NNPS en-wikipedia-org-9224 100 22 . . . en-wikipedia-org-9224 101 1 [ [ -LRB- en-wikipedia-org-9224 101 2 42 42 CD en-wikipedia-org-9224 101 3 ] ] -RRB- en-wikipedia-org-9224 101 4 In in IN en-wikipedia-org-9224 101 5 humans human NNS en-wikipedia-org-9224 101 6 , , , en-wikipedia-org-9224 101 7 this this DT en-wikipedia-org-9224 101 8 response response NN en-wikipedia-org-9224 101 9 is be VBZ en-wikipedia-org-9224 101 10 activated activate VBN en-wikipedia-org-9224 101 11 by by IN en-wikipedia-org-9224 101 12 complement complement NN en-wikipedia-org-9224 101 13 binding bind VBG en-wikipedia-org-9224 101 14 to to IN en-wikipedia-org-9224 101 15 antibodies antibody NNS en-wikipedia-org-9224 101 16 that that WDT en-wikipedia-org-9224 101 17 have have VBP en-wikipedia-org-9224 101 18 attached attach VBN en-wikipedia-org-9224 101 19 to to IN en-wikipedia-org-9224 101 20 these these DT en-wikipedia-org-9224 101 21 microbes microbe NNS en-wikipedia-org-9224 101 22 or or CC en-wikipedia-org-9224 101 23 the the DT en-wikipedia-org-9224 101 24 binding binding NN en-wikipedia-org-9224 101 25 of of IN en-wikipedia-org-9224 101 26 complement complement JJ en-wikipedia-org-9224 101 27 proteins protein NNS en-wikipedia-org-9224 101 28 to to IN en-wikipedia-org-9224 101 29 carbohydrates carbohydrate NNS en-wikipedia-org-9224 101 30 on on IN en-wikipedia-org-9224 101 31 the the DT en-wikipedia-org-9224 101 32 surfaces surface NNS en-wikipedia-org-9224 101 33 of of IN en-wikipedia-org-9224 101 34 microbes microbe NNS en-wikipedia-org-9224 101 35 . . . en-wikipedia-org-9224 102 1 This this DT en-wikipedia-org-9224 102 2 recognition recognition NN en-wikipedia-org-9224 102 3 signal signal NN en-wikipedia-org-9224 102 4 triggers trigger VBZ en-wikipedia-org-9224 102 5 a a DT en-wikipedia-org-9224 102 6 rapid rapid JJ en-wikipedia-org-9224 102 7 killing killing NN en-wikipedia-org-9224 102 8 response response NN en-wikipedia-org-9224 102 9 . . . en-wikipedia-org-9224 103 1 [ [ -LRB- en-wikipedia-org-9224 103 2 52 52 CD en-wikipedia-org-9224 103 3 ] ] -RRB- en-wikipedia-org-9224 103 4 The the DT en-wikipedia-org-9224 103 5 speed speed NN en-wikipedia-org-9224 103 6 of of IN en-wikipedia-org-9224 103 7 the the DT en-wikipedia-org-9224 103 8 response response NN en-wikipedia-org-9224 103 9 is be VBZ en-wikipedia-org-9224 103 10 a a DT en-wikipedia-org-9224 103 11 result result NN en-wikipedia-org-9224 103 12 of of IN en-wikipedia-org-9224 103 13 signal signal JJ en-wikipedia-org-9224 103 14 amplification amplification NN en-wikipedia-org-9224 103 15 that that WDT en-wikipedia-org-9224 103 16 occurs occur VBZ en-wikipedia-org-9224 103 17 after after IN en-wikipedia-org-9224 103 18 sequential sequential JJ en-wikipedia-org-9224 103 19 proteolytic proteolytic JJ en-wikipedia-org-9224 103 20 activation activation NN en-wikipedia-org-9224 103 21 of of IN en-wikipedia-org-9224 103 22 complement complement NN en-wikipedia-org-9224 103 23 molecules molecule NNS en-wikipedia-org-9224 103 24 , , , en-wikipedia-org-9224 103 25 which which WDT en-wikipedia-org-9224 103 26 are be VBP en-wikipedia-org-9224 103 27 also also RB en-wikipedia-org-9224 103 28 proteases protease NNS en-wikipedia-org-9224 103 29 . . . en-wikipedia-org-9224 104 1 After after IN en-wikipedia-org-9224 104 2 complement complement NN en-wikipedia-org-9224 104 3 proteins protein NNS en-wikipedia-org-9224 104 4 initially initially RB en-wikipedia-org-9224 104 5 bind bind VBP en-wikipedia-org-9224 104 6 to to IN en-wikipedia-org-9224 104 7 the the DT en-wikipedia-org-9224 104 8 microbe microbe NN en-wikipedia-org-9224 104 9 , , , en-wikipedia-org-9224 104 10 they -PRON- PRP en-wikipedia-org-9224 104 11 activate activate VBP en-wikipedia-org-9224 104 12 their -PRON- PRP$ en-wikipedia-org-9224 104 13 protease protease NN en-wikipedia-org-9224 104 14 activity activity NN en-wikipedia-org-9224 104 15 , , , en-wikipedia-org-9224 104 16 which which WDT en-wikipedia-org-9224 104 17 in in IN en-wikipedia-org-9224 104 18 turn turn NN en-wikipedia-org-9224 104 19 activates activate VBZ en-wikipedia-org-9224 104 20 other other JJ en-wikipedia-org-9224 104 21 complement complement JJ en-wikipedia-org-9224 104 22 proteases protease NNS en-wikipedia-org-9224 104 23 , , , en-wikipedia-org-9224 104 24 and and CC en-wikipedia-org-9224 104 25 so so RB en-wikipedia-org-9224 104 26 on on RB en-wikipedia-org-9224 104 27 . . . en-wikipedia-org-9224 105 1 This this DT en-wikipedia-org-9224 105 2 produces produce VBZ en-wikipedia-org-9224 105 3 a a DT en-wikipedia-org-9224 105 4 catalytic catalytic JJ en-wikipedia-org-9224 105 5 cascade cascade NN en-wikipedia-org-9224 105 6 that that WDT en-wikipedia-org-9224 105 7 amplifies amplify VBZ en-wikipedia-org-9224 105 8 the the DT en-wikipedia-org-9224 105 9 initial initial JJ en-wikipedia-org-9224 105 10 signal signal NN en-wikipedia-org-9224 105 11 by by IN en-wikipedia-org-9224 105 12 controlled control VBN en-wikipedia-org-9224 105 13 positive positive JJ en-wikipedia-org-9224 105 14 feedback feedback NN en-wikipedia-org-9224 105 15 . . . en-wikipedia-org-9224 106 1 [ [ -LRB- en-wikipedia-org-9224 106 2 53 53 CD en-wikipedia-org-9224 106 3 ] ] -RRB- en-wikipedia-org-9224 106 4 The the DT en-wikipedia-org-9224 106 5 cascade cascade NN en-wikipedia-org-9224 106 6 results result VBZ en-wikipedia-org-9224 106 7 in in IN en-wikipedia-org-9224 106 8 the the DT en-wikipedia-org-9224 106 9 production production NN en-wikipedia-org-9224 106 10 of of IN en-wikipedia-org-9224 106 11 peptides peptide NNS en-wikipedia-org-9224 106 12 that that WDT en-wikipedia-org-9224 106 13 attract attract VBP en-wikipedia-org-9224 106 14 immune immune JJ en-wikipedia-org-9224 106 15 cells cell NNS en-wikipedia-org-9224 106 16 , , , en-wikipedia-org-9224 106 17 increase increase VB en-wikipedia-org-9224 106 18 vascular vascular JJ en-wikipedia-org-9224 106 19 permeability permeability NN en-wikipedia-org-9224 106 20 , , , en-wikipedia-org-9224 106 21 and and CC en-wikipedia-org-9224 106 22 opsonize opsonize NNP en-wikipedia-org-9224 106 23 ( ( -LRB- en-wikipedia-org-9224 106 24 coat coat NN en-wikipedia-org-9224 106 25 ) ) -RRB- en-wikipedia-org-9224 106 26 the the DT en-wikipedia-org-9224 106 27 surface surface NN en-wikipedia-org-9224 106 28 of of IN en-wikipedia-org-9224 106 29 a a DT en-wikipedia-org-9224 106 30 pathogen pathogen NN en-wikipedia-org-9224 106 31 , , , en-wikipedia-org-9224 106 32 marking mark VBG en-wikipedia-org-9224 106 33 it -PRON- PRP en-wikipedia-org-9224 106 34 for for IN en-wikipedia-org-9224 106 35 destruction destruction NN en-wikipedia-org-9224 106 36 . . . en-wikipedia-org-9224 107 1 This this DT en-wikipedia-org-9224 107 2 deposition deposition NN en-wikipedia-org-9224 107 3 of of IN en-wikipedia-org-9224 107 4 complement complement NN en-wikipedia-org-9224 107 5 can can MD en-wikipedia-org-9224 107 6 also also RB en-wikipedia-org-9224 107 7 kill kill VB en-wikipedia-org-9224 107 8 cells cell NNS en-wikipedia-org-9224 107 9 directly directly RB en-wikipedia-org-9224 107 10 by by IN en-wikipedia-org-9224 107 11 disrupting disrupt VBG en-wikipedia-org-9224 107 12 their -PRON- PRP$ en-wikipedia-org-9224 107 13 plasma plasma NN en-wikipedia-org-9224 107 14 membrane membrane NN en-wikipedia-org-9224 107 15 . . . en-wikipedia-org-9224 108 1 [ [ -LRB- en-wikipedia-org-9224 108 2 50 50 CD en-wikipedia-org-9224 108 3 ] ] -RRB- en-wikipedia-org-9224 108 4 Adaptive adaptive JJ en-wikipedia-org-9224 108 5 immune immune NN en-wikipedia-org-9224 108 6 system[edit system[edit . en-wikipedia-org-9224 108 7 ] ] -RRB- en-wikipedia-org-9224 108 8 Further further JJ en-wikipedia-org-9224 108 9 information information NN en-wikipedia-org-9224 108 10 : : : en-wikipedia-org-9224 108 11 Adaptive adaptive JJ en-wikipedia-org-9224 108 12 immune immune JJ en-wikipedia-org-9224 108 13 system system NN en-wikipedia-org-9224 108 14 Overview Overview NNP en-wikipedia-org-9224 108 15 of of IN en-wikipedia-org-9224 108 16 the the DT en-wikipedia-org-9224 108 17 processes process NNS en-wikipedia-org-9224 108 18 involved involve VBN en-wikipedia-org-9224 108 19 in in IN en-wikipedia-org-9224 108 20 the the DT en-wikipedia-org-9224 108 21 primary primary JJ en-wikipedia-org-9224 108 22 immune immune JJ en-wikipedia-org-9224 108 23 response response NN en-wikipedia-org-9224 108 24 The the DT en-wikipedia-org-9224 108 25 adaptive adaptive JJ en-wikipedia-org-9224 108 26 immune immune JJ en-wikipedia-org-9224 108 27 system system NN en-wikipedia-org-9224 108 28 evolved evolve VBN en-wikipedia-org-9224 108 29 in in IN en-wikipedia-org-9224 108 30 early early JJ en-wikipedia-org-9224 108 31 vertebrates vertebrate NNS en-wikipedia-org-9224 108 32 and and CC en-wikipedia-org-9224 108 33 allows allow VBZ en-wikipedia-org-9224 108 34 for for IN en-wikipedia-org-9224 108 35 a a DT en-wikipedia-org-9224 108 36 stronger strong JJR en-wikipedia-org-9224 108 37 immune immune JJ en-wikipedia-org-9224 108 38 response response NN en-wikipedia-org-9224 108 39 as as RB en-wikipedia-org-9224 108 40 well well RB en-wikipedia-org-9224 108 41 as as IN en-wikipedia-org-9224 108 42 immunological immunological JJ en-wikipedia-org-9224 108 43 memory memory NN en-wikipedia-org-9224 108 44 , , , en-wikipedia-org-9224 108 45 where where WRB en-wikipedia-org-9224 108 46 each each DT en-wikipedia-org-9224 108 47 pathogen pathogen NN en-wikipedia-org-9224 108 48 is be VBZ en-wikipedia-org-9224 108 49 " " `` en-wikipedia-org-9224 108 50 remembered remember VBN en-wikipedia-org-9224 108 51 " " '' en-wikipedia-org-9224 108 52 by by IN en-wikipedia-org-9224 108 53 a a DT en-wikipedia-org-9224 108 54 signature signature NN en-wikipedia-org-9224 108 55 antigen antigen NN en-wikipedia-org-9224 108 56 . . . en-wikipedia-org-9224 109 1 [ [ -LRB- en-wikipedia-org-9224 109 2 54 54 CD en-wikipedia-org-9224 109 3 ] ] -RRB- en-wikipedia-org-9224 109 4 The the DT en-wikipedia-org-9224 109 5 adaptive adaptive JJ en-wikipedia-org-9224 109 6 immune immune JJ en-wikipedia-org-9224 109 7 response response NN en-wikipedia-org-9224 109 8 is be VBZ en-wikipedia-org-9224 109 9 antigen antigen NN en-wikipedia-org-9224 109 10 - - HYPH en-wikipedia-org-9224 109 11 specific specific NN en-wikipedia-org-9224 109 12 and and CC en-wikipedia-org-9224 109 13 requires require VBZ en-wikipedia-org-9224 109 14 the the DT en-wikipedia-org-9224 109 15 recognition recognition NN en-wikipedia-org-9224 109 16 of of IN en-wikipedia-org-9224 109 17 specific specific JJ en-wikipedia-org-9224 109 18 " " `` en-wikipedia-org-9224 109 19 non non JJ en-wikipedia-org-9224 109 20 - - JJ en-wikipedia-org-9224 109 21 self self JJ en-wikipedia-org-9224 109 22 " " '' en-wikipedia-org-9224 109 23 antigens antigen NNS en-wikipedia-org-9224 109 24 during during IN en-wikipedia-org-9224 109 25 a a DT en-wikipedia-org-9224 109 26 process process NN en-wikipedia-org-9224 109 27 called call VBN en-wikipedia-org-9224 109 28 antigen antigen NNP en-wikipedia-org-9224 109 29 presentation presentation NN en-wikipedia-org-9224 109 30 . . . en-wikipedia-org-9224 110 1 Antigen Antigen NNP en-wikipedia-org-9224 110 2 specificity specificity NN en-wikipedia-org-9224 110 3 allows allow VBZ en-wikipedia-org-9224 110 4 for for IN en-wikipedia-org-9224 110 5 the the DT en-wikipedia-org-9224 110 6 generation generation NN en-wikipedia-org-9224 110 7 of of IN en-wikipedia-org-9224 110 8 responses response NNS en-wikipedia-org-9224 110 9 that that WDT en-wikipedia-org-9224 110 10 are be VBP en-wikipedia-org-9224 110 11 tailored tailor VBN en-wikipedia-org-9224 110 12 to to IN en-wikipedia-org-9224 110 13 specific specific JJ en-wikipedia-org-9224 110 14 pathogens pathogen NNS en-wikipedia-org-9224 110 15 or or CC en-wikipedia-org-9224 110 16 pathogen pathogen NN en-wikipedia-org-9224 110 17 - - HYPH en-wikipedia-org-9224 110 18 infected infect VBN en-wikipedia-org-9224 110 19 cells cell NNS en-wikipedia-org-9224 110 20 . . . en-wikipedia-org-9224 111 1 The the DT en-wikipedia-org-9224 111 2 ability ability NN en-wikipedia-org-9224 111 3 to to TO en-wikipedia-org-9224 111 4 mount mount VB en-wikipedia-org-9224 111 5 these these DT en-wikipedia-org-9224 111 6 tailored tailor VBN en-wikipedia-org-9224 111 7 responses response NNS en-wikipedia-org-9224 111 8 is be VBZ en-wikipedia-org-9224 111 9 maintained maintain VBN en-wikipedia-org-9224 111 10 in in IN en-wikipedia-org-9224 111 11 the the DT en-wikipedia-org-9224 111 12 body body NN en-wikipedia-org-9224 111 13 by by IN en-wikipedia-org-9224 111 14 " " `` en-wikipedia-org-9224 111 15 memory memory NN en-wikipedia-org-9224 111 16 cells cell NNS en-wikipedia-org-9224 111 17 " " '' en-wikipedia-org-9224 111 18 . . . en-wikipedia-org-9224 112 1 Should Should MD en-wikipedia-org-9224 112 2 a a DT en-wikipedia-org-9224 112 3 pathogen pathogen NN en-wikipedia-org-9224 112 4 infect infect VB en-wikipedia-org-9224 112 5 the the DT en-wikipedia-org-9224 112 6 body body NN en-wikipedia-org-9224 112 7 more more RBR en-wikipedia-org-9224 112 8 than than IN en-wikipedia-org-9224 112 9 once once RB en-wikipedia-org-9224 112 10 , , , en-wikipedia-org-9224 112 11 these these DT en-wikipedia-org-9224 112 12 specific specific JJ en-wikipedia-org-9224 112 13 memory memory NN en-wikipedia-org-9224 112 14 cells cell NNS en-wikipedia-org-9224 112 15 are be VBP en-wikipedia-org-9224 112 16 used use VBN en-wikipedia-org-9224 112 17 to to TO en-wikipedia-org-9224 112 18 quickly quickly RB en-wikipedia-org-9224 112 19 eliminate eliminate VB en-wikipedia-org-9224 112 20 it -PRON- PRP en-wikipedia-org-9224 112 21 . . . en-wikipedia-org-9224 113 1 [ [ -LRB- en-wikipedia-org-9224 113 2 55 55 CD en-wikipedia-org-9224 113 3 ] ] -RRB- en-wikipedia-org-9224 113 4 Recognition recognition NN en-wikipedia-org-9224 113 5 of of IN en-wikipedia-org-9224 113 6 antigen[edit antigen[edit LS en-wikipedia-org-9224 113 7 ] ] -RRB- en-wikipedia-org-9224 113 8 The the DT en-wikipedia-org-9224 113 9 cells cell NNS en-wikipedia-org-9224 113 10 of of IN en-wikipedia-org-9224 113 11 the the DT en-wikipedia-org-9224 113 12 adaptive adaptive JJ en-wikipedia-org-9224 113 13 immune immune JJ en-wikipedia-org-9224 113 14 system system NN en-wikipedia-org-9224 113 15 are be VBP en-wikipedia-org-9224 113 16 special special JJ en-wikipedia-org-9224 113 17 types type NNS en-wikipedia-org-9224 113 18 of of IN en-wikipedia-org-9224 113 19 leukocytes leukocyte NNS en-wikipedia-org-9224 113 20 , , , en-wikipedia-org-9224 113 21 called call VBN en-wikipedia-org-9224 113 22 lymphocytes lymphocyte NNS en-wikipedia-org-9224 113 23 . . . en-wikipedia-org-9224 114 1 B b NN en-wikipedia-org-9224 114 2 cells cell NNS en-wikipedia-org-9224 114 3 and and CC en-wikipedia-org-9224 114 4 T t NN en-wikipedia-org-9224 114 5 cells cell NNS en-wikipedia-org-9224 114 6 are be VBP en-wikipedia-org-9224 114 7 the the DT en-wikipedia-org-9224 114 8 major major JJ en-wikipedia-org-9224 114 9 types type NNS en-wikipedia-org-9224 114 10 of of IN en-wikipedia-org-9224 114 11 lymphocytes lymphocyte NNS en-wikipedia-org-9224 114 12 and and CC en-wikipedia-org-9224 114 13 are be VBP en-wikipedia-org-9224 114 14 derived derive VBN en-wikipedia-org-9224 114 15 from from IN en-wikipedia-org-9224 114 16 hematopoietic hematopoietic JJ en-wikipedia-org-9224 114 17 stem stem NN en-wikipedia-org-9224 114 18 cells cell NNS en-wikipedia-org-9224 114 19 in in IN en-wikipedia-org-9224 114 20 the the DT en-wikipedia-org-9224 114 21 bone bone NN en-wikipedia-org-9224 114 22 marrow marrow NN en-wikipedia-org-9224 114 23 . . . en-wikipedia-org-9224 115 1 [ [ -LRB- en-wikipedia-org-9224 115 2 42 42 CD en-wikipedia-org-9224 115 3 ] ] -RRB- en-wikipedia-org-9224 115 4 B b NN en-wikipedia-org-9224 115 5 cells cell NNS en-wikipedia-org-9224 115 6 are be VBP en-wikipedia-org-9224 115 7 involved involve VBN en-wikipedia-org-9224 115 8 in in IN en-wikipedia-org-9224 115 9 the the DT en-wikipedia-org-9224 115 10 humoral humoral JJ en-wikipedia-org-9224 115 11 immune immune JJ en-wikipedia-org-9224 115 12 response response NN en-wikipedia-org-9224 115 13 , , , en-wikipedia-org-9224 115 14 whereas whereas IN en-wikipedia-org-9224 115 15 T t NN en-wikipedia-org-9224 115 16 cells cell NNS en-wikipedia-org-9224 115 17 are be VBP en-wikipedia-org-9224 115 18 involved involve VBN en-wikipedia-org-9224 115 19 in in IN en-wikipedia-org-9224 115 20 cell cell NN en-wikipedia-org-9224 115 21 - - HYPH en-wikipedia-org-9224 115 22 mediated mediate VBN en-wikipedia-org-9224 115 23 immune immune JJ en-wikipedia-org-9224 115 24 response response NN en-wikipedia-org-9224 115 25 . . . en-wikipedia-org-9224 116 1 Killer killer NN en-wikipedia-org-9224 116 2 T t NN en-wikipedia-org-9224 116 3 cells cell NNS en-wikipedia-org-9224 116 4 only only RB en-wikipedia-org-9224 116 5 recognize recognize VBP en-wikipedia-org-9224 116 6 antigens antigen NNS en-wikipedia-org-9224 116 7 coupled couple VBN en-wikipedia-org-9224 116 8 to to IN en-wikipedia-org-9224 116 9 Class Class NNP en-wikipedia-org-9224 116 10 I -PRON- PRP en-wikipedia-org-9224 116 11 MHC MHC NNP en-wikipedia-org-9224 116 12 molecules molecule NNS en-wikipedia-org-9224 116 13 , , , en-wikipedia-org-9224 116 14 while while IN en-wikipedia-org-9224 116 15 helper helper NN en-wikipedia-org-9224 116 16 T t NN en-wikipedia-org-9224 116 17 cells cell NNS en-wikipedia-org-9224 116 18 and and CC en-wikipedia-org-9224 116 19 regulatory regulatory JJ en-wikipedia-org-9224 116 20 T t NN en-wikipedia-org-9224 116 21 cells cell NNS en-wikipedia-org-9224 116 22 only only RB en-wikipedia-org-9224 116 23 recognize recognize VBP en-wikipedia-org-9224 116 24 antigens antigen NNS en-wikipedia-org-9224 116 25 coupled couple VBN en-wikipedia-org-9224 116 26 to to IN en-wikipedia-org-9224 116 27 Class Class NNP en-wikipedia-org-9224 116 28 II II NNP en-wikipedia-org-9224 116 29 MHC MHC NNP en-wikipedia-org-9224 116 30 molecules molecule NNS en-wikipedia-org-9224 116 31 . . . en-wikipedia-org-9224 117 1 These these DT en-wikipedia-org-9224 117 2 two two CD en-wikipedia-org-9224 117 3 mechanisms mechanism NNS en-wikipedia-org-9224 117 4 of of IN en-wikipedia-org-9224 117 5 antigen antigen NNP en-wikipedia-org-9224 117 6 presentation presentation NNP en-wikipedia-org-9224 117 7 reflect reflect VBP en-wikipedia-org-9224 117 8 the the DT en-wikipedia-org-9224 117 9 different different JJ en-wikipedia-org-9224 117 10 roles role NNS en-wikipedia-org-9224 117 11 of of IN en-wikipedia-org-9224 117 12 the the DT en-wikipedia-org-9224 117 13 two two CD en-wikipedia-org-9224 117 14 types type NNS en-wikipedia-org-9224 117 15 of of IN en-wikipedia-org-9224 117 16 T T NNP en-wikipedia-org-9224 117 17 cell cell NN en-wikipedia-org-9224 117 18 . . . en-wikipedia-org-9224 118 1 A a DT en-wikipedia-org-9224 118 2 third third JJ en-wikipedia-org-9224 118 3 , , , en-wikipedia-org-9224 118 4 minor minor JJ en-wikipedia-org-9224 118 5 subtype subtype NN en-wikipedia-org-9224 118 6 are be VBP en-wikipedia-org-9224 118 7 the the DT en-wikipedia-org-9224 118 8 γδ γδ NNP en-wikipedia-org-9224 118 9 T T NNP en-wikipedia-org-9224 118 10 cells cell NNS en-wikipedia-org-9224 118 11 that that WDT en-wikipedia-org-9224 118 12 recognize recognize VBP en-wikipedia-org-9224 118 13 intact intact JJ en-wikipedia-org-9224 118 14 antigens antigen NNS en-wikipedia-org-9224 118 15 that that WDT en-wikipedia-org-9224 118 16 are be VBP en-wikipedia-org-9224 118 17 not not RB en-wikipedia-org-9224 118 18 bound bind VBN en-wikipedia-org-9224 118 19 to to IN en-wikipedia-org-9224 118 20 MHC MHC NNP en-wikipedia-org-9224 118 21 receptors receptor NNS en-wikipedia-org-9224 118 22 . . . en-wikipedia-org-9224 119 1 [ [ -LRB- en-wikipedia-org-9224 119 2 56 56 CD en-wikipedia-org-9224 119 3 ] ] -RRB- en-wikipedia-org-9224 119 4 The the DT en-wikipedia-org-9224 119 5 double double JJ en-wikipedia-org-9224 119 6 - - HYPH en-wikipedia-org-9224 119 7 positive positive JJ en-wikipedia-org-9224 119 8 T t NN en-wikipedia-org-9224 119 9 cells cell NNS en-wikipedia-org-9224 119 10 are be VBP en-wikipedia-org-9224 119 11 exposed expose VBN en-wikipedia-org-9224 119 12 to to IN en-wikipedia-org-9224 119 13 a a DT en-wikipedia-org-9224 119 14 wide wide JJ en-wikipedia-org-9224 119 15 variety variety NN en-wikipedia-org-9224 119 16 of of IN en-wikipedia-org-9224 119 17 self self NN en-wikipedia-org-9224 119 18 - - HYPH en-wikipedia-org-9224 119 19 antigens antigen NNS en-wikipedia-org-9224 119 20 in in IN en-wikipedia-org-9224 119 21 the the DT en-wikipedia-org-9224 119 22 thymus thymus NN en-wikipedia-org-9224 119 23 , , , en-wikipedia-org-9224 119 24 in in IN en-wikipedia-org-9224 119 25 which which WDT en-wikipedia-org-9224 119 26 iodine iodine NN en-wikipedia-org-9224 119 27 is be VBZ en-wikipedia-org-9224 119 28 necessary necessary JJ en-wikipedia-org-9224 119 29 for for IN en-wikipedia-org-9224 119 30 its -PRON- PRP$ en-wikipedia-org-9224 119 31 thymus thymus NN en-wikipedia-org-9224 119 32 development development NN en-wikipedia-org-9224 119 33 and and CC en-wikipedia-org-9224 119 34 activity activity NN en-wikipedia-org-9224 119 35 . . . en-wikipedia-org-9224 120 1 [ [ -LRB- en-wikipedia-org-9224 120 2 57 57 CD en-wikipedia-org-9224 120 3 ] ] -RRB- en-wikipedia-org-9224 120 4 In in IN en-wikipedia-org-9224 120 5 contrast contrast NN en-wikipedia-org-9224 120 6 , , , en-wikipedia-org-9224 120 7 the the DT en-wikipedia-org-9224 120 8 B B NNP en-wikipedia-org-9224 120 9 cell cell NN en-wikipedia-org-9224 120 10 antigen antigen NN en-wikipedia-org-9224 120 11 - - HYPH en-wikipedia-org-9224 120 12 specific specific JJ en-wikipedia-org-9224 120 13 receptor receptor NN en-wikipedia-org-9224 120 14 is be VBZ en-wikipedia-org-9224 120 15 an an DT en-wikipedia-org-9224 120 16 antibody antibody NN en-wikipedia-org-9224 120 17 molecule molecule NN en-wikipedia-org-9224 120 18 on on IN en-wikipedia-org-9224 120 19 the the DT en-wikipedia-org-9224 120 20 B b NN en-wikipedia-org-9224 120 21 cell cell NN en-wikipedia-org-9224 120 22 surface surface NN en-wikipedia-org-9224 120 23 and and CC en-wikipedia-org-9224 120 24 recognizes recognize VBZ en-wikipedia-org-9224 120 25 native native JJ en-wikipedia-org-9224 120 26 ( ( -LRB- en-wikipedia-org-9224 120 27 unprocessed unprocessed JJ en-wikipedia-org-9224 120 28 ) ) -RRB- en-wikipedia-org-9224 120 29 antigen antigen NN en-wikipedia-org-9224 120 30 without without IN en-wikipedia-org-9224 120 31 any any DT en-wikipedia-org-9224 120 32 need need NN en-wikipedia-org-9224 120 33 for for IN en-wikipedia-org-9224 120 34 antigen antigen NN en-wikipedia-org-9224 120 35 processing processing NN en-wikipedia-org-9224 120 36 . . . en-wikipedia-org-9224 121 1 Such such JJ en-wikipedia-org-9224 121 2 antigens antigen NNS en-wikipedia-org-9224 121 3 may may MD en-wikipedia-org-9224 121 4 be be VB en-wikipedia-org-9224 121 5 large large JJ en-wikipedia-org-9224 121 6 molecules molecule NNS en-wikipedia-org-9224 121 7 found find VBN en-wikipedia-org-9224 121 8 on on IN en-wikipedia-org-9224 121 9 the the DT en-wikipedia-org-9224 121 10 surfaces surface NNS en-wikipedia-org-9224 121 11 of of IN en-wikipedia-org-9224 121 12 pathogens pathogen NNS en-wikipedia-org-9224 121 13 , , , en-wikipedia-org-9224 121 14 but but CC en-wikipedia-org-9224 121 15 can can MD en-wikipedia-org-9224 121 16 also also RB en-wikipedia-org-9224 121 17 be be VB en-wikipedia-org-9224 121 18 small small JJ en-wikipedia-org-9224 121 19 haptens hapten NNS en-wikipedia-org-9224 121 20 ( ( -LRB- en-wikipedia-org-9224 121 21 such such JJ en-wikipedia-org-9224 121 22 as as IN en-wikipedia-org-9224 121 23 penicillin penicillin NN en-wikipedia-org-9224 121 24 ) ) -RRB- en-wikipedia-org-9224 121 25 attached attach VBD en-wikipedia-org-9224 121 26 to to IN en-wikipedia-org-9224 121 27 carrier carrier NN en-wikipedia-org-9224 121 28 molecule molecule NN en-wikipedia-org-9224 121 29 . . . en-wikipedia-org-9224 122 1 [ [ -LRB- en-wikipedia-org-9224 122 2 58 58 CD en-wikipedia-org-9224 122 3 ] ] -RRB- en-wikipedia-org-9224 122 4 Each each DT en-wikipedia-org-9224 122 5 lineage lineage NN en-wikipedia-org-9224 122 6 of of IN en-wikipedia-org-9224 122 7 B b NN en-wikipedia-org-9224 122 8 cell cell NN en-wikipedia-org-9224 122 9 expresses express VBZ en-wikipedia-org-9224 122 10 a a DT en-wikipedia-org-9224 122 11 different different JJ en-wikipedia-org-9224 122 12 antibody antibody NN en-wikipedia-org-9224 122 13 , , , en-wikipedia-org-9224 122 14 so so RB en-wikipedia-org-9224 122 15 the the DT en-wikipedia-org-9224 122 16 complete complete JJ en-wikipedia-org-9224 122 17 set set NN en-wikipedia-org-9224 122 18 of of IN en-wikipedia-org-9224 122 19 B b NN en-wikipedia-org-9224 122 20 cell cell NN en-wikipedia-org-9224 122 21 antigen antigen NN en-wikipedia-org-9224 122 22 receptors receptor NNS en-wikipedia-org-9224 122 23 represent represent VBP en-wikipedia-org-9224 122 24 all all PDT en-wikipedia-org-9224 122 25 the the DT en-wikipedia-org-9224 122 26 antibodies antibody NNS en-wikipedia-org-9224 122 27 that that IN en-wikipedia-org-9224 122 28 the the DT en-wikipedia-org-9224 122 29 body body NN en-wikipedia-org-9224 122 30 can can MD en-wikipedia-org-9224 122 31 manufacture manufacture VB en-wikipedia-org-9224 122 32 . . . en-wikipedia-org-9224 123 1 [ [ -LRB- en-wikipedia-org-9224 123 2 42 42 CD en-wikipedia-org-9224 123 3 ] ] -RRB- en-wikipedia-org-9224 123 4 When when WRB en-wikipedia-org-9224 123 5 B b NN en-wikipedia-org-9224 123 6 or or CC en-wikipedia-org-9224 123 7 T t NN en-wikipedia-org-9224 123 8 cells cell NNS en-wikipedia-org-9224 123 9 encounter encounter VBP en-wikipedia-org-9224 123 10 their -PRON- PRP$ en-wikipedia-org-9224 123 11 related relate VBN en-wikipedia-org-9224 123 12 antigens antigen NNS en-wikipedia-org-9224 123 13 they -PRON- PRP en-wikipedia-org-9224 123 14 multiply multiply VBP en-wikipedia-org-9224 123 15 and and CC en-wikipedia-org-9224 123 16 many many JJ en-wikipedia-org-9224 123 17 " " `` en-wikipedia-org-9224 123 18 clones clone NNS en-wikipedia-org-9224 123 19 " " '' en-wikipedia-org-9224 123 20 of of IN en-wikipedia-org-9224 123 21 the the DT en-wikipedia-org-9224 123 22 cells cell NNS en-wikipedia-org-9224 123 23 are be VBP en-wikipedia-org-9224 123 24 produced produce VBN en-wikipedia-org-9224 123 25 that that IN en-wikipedia-org-9224 123 26 target target NN en-wikipedia-org-9224 123 27 the the DT en-wikipedia-org-9224 123 28 same same JJ en-wikipedia-org-9224 123 29 antigen antigen NN en-wikipedia-org-9224 123 30 . . . en-wikipedia-org-9224 124 1 This this DT en-wikipedia-org-9224 124 2 is be VBZ en-wikipedia-org-9224 124 3 called call VBN en-wikipedia-org-9224 124 4 clonal clonal JJ en-wikipedia-org-9224 124 5 selection selection NN en-wikipedia-org-9224 124 6 . . . en-wikipedia-org-9224 125 1 [ [ -LRB- en-wikipedia-org-9224 125 2 59 59 CD en-wikipedia-org-9224 125 3 ] ] -RRB- en-wikipedia-org-9224 125 4 Antigen Antigen NNP en-wikipedia-org-9224 125 5 presentation presentation NN en-wikipedia-org-9224 125 6 to to IN en-wikipedia-org-9224 125 7 T T NNP en-wikipedia-org-9224 125 8 lymphocytes[edit lymphocytes[edit . en-wikipedia-org-9224 125 9 ] ] -RRB- en-wikipedia-org-9224 125 10 Both both CC en-wikipedia-org-9224 125 11 B b NN en-wikipedia-org-9224 125 12 cells cell NNS en-wikipedia-org-9224 125 13 and and CC en-wikipedia-org-9224 125 14 T t NN en-wikipedia-org-9224 125 15 cells cell NNS en-wikipedia-org-9224 125 16 carry carry VBP en-wikipedia-org-9224 125 17 receptor receptor NN en-wikipedia-org-9224 125 18 molecules molecule NNS en-wikipedia-org-9224 125 19 that that WDT en-wikipedia-org-9224 125 20 recognize recognize VBP en-wikipedia-org-9224 125 21 specific specific JJ en-wikipedia-org-9224 125 22 targets target NNS en-wikipedia-org-9224 125 23 . . . en-wikipedia-org-9224 126 1 T t NN en-wikipedia-org-9224 126 2 cells cell NNS en-wikipedia-org-9224 126 3 recognize recognize VBP en-wikipedia-org-9224 126 4 a a DT en-wikipedia-org-9224 126 5 " " `` en-wikipedia-org-9224 126 6 non non JJ en-wikipedia-org-9224 126 7 - - JJ en-wikipedia-org-9224 126 8 self self JJ en-wikipedia-org-9224 126 9 " " '' en-wikipedia-org-9224 126 10 target target NN en-wikipedia-org-9224 126 11 , , , en-wikipedia-org-9224 126 12 such such JJ en-wikipedia-org-9224 126 13 as as IN en-wikipedia-org-9224 126 14 a a DT en-wikipedia-org-9224 126 15 pathogen pathogen NN en-wikipedia-org-9224 126 16 , , , en-wikipedia-org-9224 126 17 only only RB en-wikipedia-org-9224 126 18 after after IN en-wikipedia-org-9224 126 19 antigens antigen NNS en-wikipedia-org-9224 126 20 ( ( -LRB- en-wikipedia-org-9224 126 21 small small JJ en-wikipedia-org-9224 126 22 fragments fragment NNS en-wikipedia-org-9224 126 23 of of IN en-wikipedia-org-9224 126 24 the the DT en-wikipedia-org-9224 126 25 pathogen pathogen NN en-wikipedia-org-9224 126 26 ) ) -RRB- en-wikipedia-org-9224 126 27 have have VBP en-wikipedia-org-9224 126 28 been be VBN en-wikipedia-org-9224 126 29 processed process VBN en-wikipedia-org-9224 126 30 and and CC en-wikipedia-org-9224 126 31 presented present VBN en-wikipedia-org-9224 126 32 in in IN en-wikipedia-org-9224 126 33 combination combination NN en-wikipedia-org-9224 126 34 with with IN en-wikipedia-org-9224 126 35 a a DT en-wikipedia-org-9224 126 36 " " `` en-wikipedia-org-9224 126 37 self self NN en-wikipedia-org-9224 126 38 " " '' en-wikipedia-org-9224 126 39 receptor receptor NN en-wikipedia-org-9224 126 40 called call VBD en-wikipedia-org-9224 126 41 a a DT en-wikipedia-org-9224 126 42 major major JJ en-wikipedia-org-9224 126 43 histocompatibility histocompatibility NN en-wikipedia-org-9224 126 44 complex complex NN en-wikipedia-org-9224 126 45 ( ( -LRB- en-wikipedia-org-9224 126 46 MHC MHC NNP en-wikipedia-org-9224 126 47 ) ) -RRB- en-wikipedia-org-9224 126 48 molecule molecule VBP en-wikipedia-org-9224 126 49 . . . en-wikipedia-org-9224 127 1 [ [ -LRB- en-wikipedia-org-9224 127 2 60 60 CD en-wikipedia-org-9224 127 3 ] ] -RRB- en-wikipedia-org-9224 127 4 Cell Cell NNP en-wikipedia-org-9224 127 5 mediated mediate VBD en-wikipedia-org-9224 127 6 immunity[edit immunity[edit LS en-wikipedia-org-9224 127 7 ] ] -RRB- en-wikipedia-org-9224 127 8 There there EX en-wikipedia-org-9224 127 9 are be VBP en-wikipedia-org-9224 127 10 two two CD en-wikipedia-org-9224 127 11 major major JJ en-wikipedia-org-9224 127 12 subtypes subtype NNS en-wikipedia-org-9224 127 13 of of IN en-wikipedia-org-9224 127 14 T t NN en-wikipedia-org-9224 127 15 cells cell NNS en-wikipedia-org-9224 127 16 : : : en-wikipedia-org-9224 127 17 the the DT en-wikipedia-org-9224 127 18 killer killer NN en-wikipedia-org-9224 127 19 T T NNP en-wikipedia-org-9224 127 20 cell cell NN en-wikipedia-org-9224 127 21 and and CC en-wikipedia-org-9224 127 22 the the DT en-wikipedia-org-9224 127 23 helper helper NN en-wikipedia-org-9224 127 24 T T NNP en-wikipedia-org-9224 127 25 cell cell NN en-wikipedia-org-9224 127 26 . . . en-wikipedia-org-9224 128 1 In in IN en-wikipedia-org-9224 128 2 addition addition NN en-wikipedia-org-9224 128 3 there there EX en-wikipedia-org-9224 128 4 are be VBP en-wikipedia-org-9224 128 5 regulatory regulatory JJ en-wikipedia-org-9224 128 6 T t NN en-wikipedia-org-9224 128 7 cells cell NNS en-wikipedia-org-9224 128 8 which which WDT en-wikipedia-org-9224 128 9 have have VBP en-wikipedia-org-9224 128 10 a a DT en-wikipedia-org-9224 128 11 role role NN en-wikipedia-org-9224 128 12 in in IN en-wikipedia-org-9224 128 13 modulating modulate VBG en-wikipedia-org-9224 128 14 immune immune JJ en-wikipedia-org-9224 128 15 response response NN en-wikipedia-org-9224 128 16 . . . en-wikipedia-org-9224 129 1 [ [ -LRB- en-wikipedia-org-9224 129 2 61 61 CD en-wikipedia-org-9224 129 3 ] ] -RRB- en-wikipedia-org-9224 129 4 Killer Killer NNP en-wikipedia-org-9224 129 5 T T NNP en-wikipedia-org-9224 129 6 cells[edit cells[edit NNP en-wikipedia-org-9224 129 7 ] ] -RRB- en-wikipedia-org-9224 129 8 Killer Killer NNP en-wikipedia-org-9224 129 9 T T NNP en-wikipedia-org-9224 129 10 cells cell NNS en-wikipedia-org-9224 129 11 are be VBP en-wikipedia-org-9224 129 12 a a DT en-wikipedia-org-9224 129 13 sub sub NN en-wikipedia-org-9224 129 14 - - NN en-wikipedia-org-9224 129 15 group group NN en-wikipedia-org-9224 129 16 of of IN en-wikipedia-org-9224 129 17 T T NNP en-wikipedia-org-9224 129 18 cells cell NNS en-wikipedia-org-9224 129 19 that that WDT en-wikipedia-org-9224 129 20 kill kill VBP en-wikipedia-org-9224 129 21 cells cell NNS en-wikipedia-org-9224 129 22 that that WDT en-wikipedia-org-9224 129 23 are be VBP en-wikipedia-org-9224 129 24 infected infect VBN en-wikipedia-org-9224 129 25 with with IN en-wikipedia-org-9224 129 26 viruses virus NNS en-wikipedia-org-9224 129 27 ( ( -LRB- en-wikipedia-org-9224 129 28 and and CC en-wikipedia-org-9224 129 29 other other JJ en-wikipedia-org-9224 129 30 pathogens pathogen NNS en-wikipedia-org-9224 129 31 ) ) -RRB- en-wikipedia-org-9224 129 32 , , , en-wikipedia-org-9224 129 33 or or CC en-wikipedia-org-9224 129 34 are be VBP en-wikipedia-org-9224 129 35 otherwise otherwise RB en-wikipedia-org-9224 129 36 damaged damaged JJ en-wikipedia-org-9224 129 37 or or CC en-wikipedia-org-9224 129 38 dysfunctional dysfunctional JJ en-wikipedia-org-9224 129 39 . . . en-wikipedia-org-9224 130 1 [ [ -LRB- en-wikipedia-org-9224 130 2 62 62 CD en-wikipedia-org-9224 130 3 ] ] -RRB- en-wikipedia-org-9224 130 4 As as IN en-wikipedia-org-9224 130 5 with with IN en-wikipedia-org-9224 130 6 B b NN en-wikipedia-org-9224 130 7 cells cell NNS en-wikipedia-org-9224 130 8 , , , en-wikipedia-org-9224 130 9 each each DT en-wikipedia-org-9224 130 10 type type NN en-wikipedia-org-9224 130 11 of of IN en-wikipedia-org-9224 130 12 T t NN en-wikipedia-org-9224 130 13 cell cell NN en-wikipedia-org-9224 130 14 recognizes recognize VBZ en-wikipedia-org-9224 130 15 a a DT en-wikipedia-org-9224 130 16 different different JJ en-wikipedia-org-9224 130 17 antigen antigen NN en-wikipedia-org-9224 130 18 . . . en-wikipedia-org-9224 131 1 Killer killer NN en-wikipedia-org-9224 131 2 T t NN en-wikipedia-org-9224 131 3 cells cell NNS en-wikipedia-org-9224 131 4 are be VBP en-wikipedia-org-9224 131 5 activated activate VBN en-wikipedia-org-9224 131 6 when when WRB en-wikipedia-org-9224 131 7 their -PRON- PRP$ en-wikipedia-org-9224 131 8 T t NN en-wikipedia-org-9224 131 9 - - HYPH en-wikipedia-org-9224 131 10 cell cell NN en-wikipedia-org-9224 131 11 receptor receptor NN en-wikipedia-org-9224 131 12 binds bind NNS en-wikipedia-org-9224 131 13 to to IN en-wikipedia-org-9224 131 14 this this DT en-wikipedia-org-9224 131 15 specific specific JJ en-wikipedia-org-9224 131 16 antigen antigen NN en-wikipedia-org-9224 131 17 in in IN en-wikipedia-org-9224 131 18 a a DT en-wikipedia-org-9224 131 19 complex complex NN en-wikipedia-org-9224 131 20 with with IN en-wikipedia-org-9224 131 21 the the DT en-wikipedia-org-9224 131 22 MHC MHC NNP en-wikipedia-org-9224 131 23 Class Class NNP en-wikipedia-org-9224 131 24 I I NNP en-wikipedia-org-9224 131 25 receptor receptor NN en-wikipedia-org-9224 131 26 of of IN en-wikipedia-org-9224 131 27 another another DT en-wikipedia-org-9224 131 28 cell cell NN en-wikipedia-org-9224 131 29 . . . en-wikipedia-org-9224 132 1 Recognition Recognition NNP en-wikipedia-org-9224 132 2 of of IN en-wikipedia-org-9224 132 3 this this DT en-wikipedia-org-9224 132 4 MHC MHC NNP en-wikipedia-org-9224 132 5 : : : en-wikipedia-org-9224 132 6 antigen antigen NNP en-wikipedia-org-9224 132 7 complex complex NN en-wikipedia-org-9224 132 8 is be VBZ en-wikipedia-org-9224 132 9 aided aid VBN en-wikipedia-org-9224 132 10 by by IN en-wikipedia-org-9224 132 11 a a DT en-wikipedia-org-9224 132 12 co co NN en-wikipedia-org-9224 132 13 - - NN en-wikipedia-org-9224 132 14 receptor receptor NN en-wikipedia-org-9224 132 15 on on IN en-wikipedia-org-9224 132 16 the the DT en-wikipedia-org-9224 132 17 T T NNP en-wikipedia-org-9224 132 18 cell cell NN en-wikipedia-org-9224 132 19 , , , en-wikipedia-org-9224 132 20 called call VBD en-wikipedia-org-9224 132 21 CD8 CD8 NNP en-wikipedia-org-9224 132 22 . . . en-wikipedia-org-9224 133 1 The the DT en-wikipedia-org-9224 133 2 T T NNP en-wikipedia-org-9224 133 3 cell cell NN en-wikipedia-org-9224 133 4 then then RB en-wikipedia-org-9224 133 5 travels travel VBZ en-wikipedia-org-9224 133 6 throughout throughout IN en-wikipedia-org-9224 133 7 the the DT en-wikipedia-org-9224 133 8 body body NN en-wikipedia-org-9224 133 9 in in IN en-wikipedia-org-9224 133 10 search search NN en-wikipedia-org-9224 133 11 of of IN en-wikipedia-org-9224 133 12 cells cell NNS en-wikipedia-org-9224 133 13 where where WRB en-wikipedia-org-9224 133 14 the the DT en-wikipedia-org-9224 133 15 MHC MHC NNP en-wikipedia-org-9224 133 16 I -PRON- PRP en-wikipedia-org-9224 133 17 receptors receptor VBZ en-wikipedia-org-9224 133 18 bear bear VBP en-wikipedia-org-9224 133 19 this this DT en-wikipedia-org-9224 133 20 antigen antigen NN en-wikipedia-org-9224 133 21 . . . en-wikipedia-org-9224 134 1 When when WRB en-wikipedia-org-9224 134 2 an an DT en-wikipedia-org-9224 134 3 activated activate VBN en-wikipedia-org-9224 134 4 T t NN en-wikipedia-org-9224 134 5 cell cell NN en-wikipedia-org-9224 134 6 contacts contact VBZ en-wikipedia-org-9224 134 7 such such JJ en-wikipedia-org-9224 134 8 cells cell NNS en-wikipedia-org-9224 134 9 , , , en-wikipedia-org-9224 134 10 it -PRON- PRP en-wikipedia-org-9224 134 11 releases release VBZ en-wikipedia-org-9224 134 12 cytotoxins cytotoxin NNS en-wikipedia-org-9224 134 13 , , , en-wikipedia-org-9224 134 14 such such JJ en-wikipedia-org-9224 134 15 as as IN en-wikipedia-org-9224 134 16 perforin perforin NNP en-wikipedia-org-9224 134 17 , , , en-wikipedia-org-9224 134 18 which which WDT en-wikipedia-org-9224 134 19 form form NN en-wikipedia-org-9224 134 20 pores pore NNS en-wikipedia-org-9224 134 21 in in IN en-wikipedia-org-9224 134 22 the the DT en-wikipedia-org-9224 134 23 target target NN en-wikipedia-org-9224 134 24 cell cell NN en-wikipedia-org-9224 134 25 's 's POS en-wikipedia-org-9224 134 26 plasma plasma NN en-wikipedia-org-9224 134 27 membrane membrane NN en-wikipedia-org-9224 134 28 , , , en-wikipedia-org-9224 134 29 allowing allow VBG en-wikipedia-org-9224 134 30 ions ion NNS en-wikipedia-org-9224 134 31 , , , en-wikipedia-org-9224 134 32 water water NN en-wikipedia-org-9224 134 33 and and CC en-wikipedia-org-9224 134 34 toxins toxin NNS en-wikipedia-org-9224 134 35 to to TO en-wikipedia-org-9224 134 36 enter enter VB en-wikipedia-org-9224 134 37 . . . en-wikipedia-org-9224 135 1 The the DT en-wikipedia-org-9224 135 2 entry entry NN en-wikipedia-org-9224 135 3 of of IN en-wikipedia-org-9224 135 4 another another DT en-wikipedia-org-9224 135 5 toxin toxin NN en-wikipedia-org-9224 135 6 called call VBN en-wikipedia-org-9224 135 7 granulysin granulysin NNP en-wikipedia-org-9224 135 8 ( ( -LRB- en-wikipedia-org-9224 135 9 a a DT en-wikipedia-org-9224 135 10 protease protease NN en-wikipedia-org-9224 135 11 ) ) -RRB- en-wikipedia-org-9224 135 12 induces induce VBZ en-wikipedia-org-9224 135 13 the the DT en-wikipedia-org-9224 135 14 target target NN en-wikipedia-org-9224 135 15 cell cell NN en-wikipedia-org-9224 135 16 to to TO en-wikipedia-org-9224 135 17 undergo undergo VB en-wikipedia-org-9224 135 18 apoptosis apoptosis NN en-wikipedia-org-9224 135 19 . . . en-wikipedia-org-9224 136 1 [ [ -LRB- en-wikipedia-org-9224 136 2 63 63 CD en-wikipedia-org-9224 136 3 ] ] -RRB- en-wikipedia-org-9224 136 4 T t NN en-wikipedia-org-9224 136 5 cell cell NN en-wikipedia-org-9224 136 6 killing killing NN en-wikipedia-org-9224 136 7 of of IN en-wikipedia-org-9224 136 8 host host NN en-wikipedia-org-9224 136 9 cells cell NNS en-wikipedia-org-9224 136 10 is be VBZ en-wikipedia-org-9224 136 11 particularly particularly RB en-wikipedia-org-9224 136 12 important important JJ en-wikipedia-org-9224 136 13 in in IN en-wikipedia-org-9224 136 14 preventing prevent VBG en-wikipedia-org-9224 136 15 the the DT en-wikipedia-org-9224 136 16 replication replication NN en-wikipedia-org-9224 136 17 of of IN en-wikipedia-org-9224 136 18 viruses virus NNS en-wikipedia-org-9224 136 19 . . . en-wikipedia-org-9224 137 1 T T NNP en-wikipedia-org-9224 137 2 cell cell NN en-wikipedia-org-9224 137 3 activation activation NN en-wikipedia-org-9224 137 4 is be VBZ en-wikipedia-org-9224 137 5 tightly tightly RB en-wikipedia-org-9224 137 6 controlled control VBN en-wikipedia-org-9224 137 7 and and CC en-wikipedia-org-9224 137 8 generally generally RB en-wikipedia-org-9224 137 9 requires require VBZ en-wikipedia-org-9224 137 10 a a DT en-wikipedia-org-9224 137 11 very very RB en-wikipedia-org-9224 137 12 strong strong JJ en-wikipedia-org-9224 137 13 MHC MHC NNP en-wikipedia-org-9224 137 14 / / SYM en-wikipedia-org-9224 137 15 antigen antigen NNP en-wikipedia-org-9224 137 16 activation activation NN en-wikipedia-org-9224 137 17 signal signal NN en-wikipedia-org-9224 137 18 , , , en-wikipedia-org-9224 137 19 or or CC en-wikipedia-org-9224 137 20 additional additional JJ en-wikipedia-org-9224 137 21 activation activation NN en-wikipedia-org-9224 137 22 signals signal NNS en-wikipedia-org-9224 137 23 provided provide VBN en-wikipedia-org-9224 137 24 by by IN en-wikipedia-org-9224 137 25 " " `` en-wikipedia-org-9224 137 26 helper helper NN en-wikipedia-org-9224 137 27 " " '' en-wikipedia-org-9224 137 28 T t NN en-wikipedia-org-9224 137 29 cells cell NNS en-wikipedia-org-9224 137 30 ( ( -LRB- en-wikipedia-org-9224 137 31 see see VB en-wikipedia-org-9224 137 32 below below RB en-wikipedia-org-9224 137 33 ) ) -RRB- en-wikipedia-org-9224 137 34 . . . en-wikipedia-org-9224 138 1 [ [ -LRB- en-wikipedia-org-9224 138 2 63 63 CD en-wikipedia-org-9224 138 3 ] ] -RRB- en-wikipedia-org-9224 138 4 Helper helper NN en-wikipedia-org-9224 138 5 T T NNP en-wikipedia-org-9224 138 6 cells[edit cells[edit NNP en-wikipedia-org-9224 138 7 ] ] -RRB- en-wikipedia-org-9224 138 8 Helper helper NN en-wikipedia-org-9224 138 9 T t NN en-wikipedia-org-9224 138 10 cells cell NNS en-wikipedia-org-9224 138 11 regulate regulate VBP en-wikipedia-org-9224 138 12 both both CC en-wikipedia-org-9224 138 13 the the DT en-wikipedia-org-9224 138 14 innate innate JJ en-wikipedia-org-9224 138 15 and and CC en-wikipedia-org-9224 138 16 adaptive adaptive JJ en-wikipedia-org-9224 138 17 immune immune JJ en-wikipedia-org-9224 138 18 responses response NNS en-wikipedia-org-9224 138 19 and and CC en-wikipedia-org-9224 138 20 help help VB en-wikipedia-org-9224 138 21 determine determine VB en-wikipedia-org-9224 138 22 which which WDT en-wikipedia-org-9224 138 23 immune immune JJ en-wikipedia-org-9224 138 24 responses response NNS en-wikipedia-org-9224 138 25 the the DT en-wikipedia-org-9224 138 26 body body NN en-wikipedia-org-9224 138 27 makes make VBZ en-wikipedia-org-9224 138 28 to to IN en-wikipedia-org-9224 138 29 a a DT en-wikipedia-org-9224 138 30 particular particular JJ en-wikipedia-org-9224 138 31 pathogen pathogen NN en-wikipedia-org-9224 138 32 . . . en-wikipedia-org-9224 139 1 [ [ -LRB- en-wikipedia-org-9224 139 2 64][65 64][65 CD en-wikipedia-org-9224 139 3 ] ] -RRB- en-wikipedia-org-9224 139 4 These these DT en-wikipedia-org-9224 139 5 cells cell NNS en-wikipedia-org-9224 139 6 have have VBP en-wikipedia-org-9224 139 7 no no DT en-wikipedia-org-9224 139 8 cytotoxic cytotoxic JJ en-wikipedia-org-9224 139 9 activity activity NN en-wikipedia-org-9224 139 10 and and CC en-wikipedia-org-9224 139 11 do do VBP en-wikipedia-org-9224 139 12 not not RB en-wikipedia-org-9224 139 13 kill kill VB en-wikipedia-org-9224 139 14 infected infected JJ en-wikipedia-org-9224 139 15 cells cell NNS en-wikipedia-org-9224 139 16 or or CC en-wikipedia-org-9224 139 17 clear clear JJ en-wikipedia-org-9224 139 18 pathogens pathogen NNS en-wikipedia-org-9224 139 19 directly directly RB en-wikipedia-org-9224 139 20 . . . en-wikipedia-org-9224 140 1 They -PRON- PRP en-wikipedia-org-9224 140 2 instead instead RB en-wikipedia-org-9224 140 3 control control VBP en-wikipedia-org-9224 140 4 the the DT en-wikipedia-org-9224 140 5 immune immune JJ en-wikipedia-org-9224 140 6 response response NN en-wikipedia-org-9224 140 7 by by IN en-wikipedia-org-9224 140 8 directing direct VBG en-wikipedia-org-9224 140 9 other other JJ en-wikipedia-org-9224 140 10 cells cell NNS en-wikipedia-org-9224 140 11 to to TO en-wikipedia-org-9224 140 12 perform perform VB en-wikipedia-org-9224 140 13 these these DT en-wikipedia-org-9224 140 14 tasks task NNS en-wikipedia-org-9224 140 15 . . . en-wikipedia-org-9224 141 1 [ [ -LRB- en-wikipedia-org-9224 141 2 66 66 CD en-wikipedia-org-9224 141 3 ] ] -RRB- en-wikipedia-org-9224 141 4 Helper helper NN en-wikipedia-org-9224 141 5 T T NNP en-wikipedia-org-9224 141 6 cells cell NNS en-wikipedia-org-9224 141 7 express express VBP en-wikipedia-org-9224 141 8 T T NNP en-wikipedia-org-9224 141 9 cell cell NN en-wikipedia-org-9224 141 10 receptors receptor NNS en-wikipedia-org-9224 141 11 that that WDT en-wikipedia-org-9224 141 12 recognize recognize VBP en-wikipedia-org-9224 141 13 antigen antigen NN en-wikipedia-org-9224 141 14 bound bind VBN en-wikipedia-org-9224 141 15 to to IN en-wikipedia-org-9224 141 16 Class Class NNP en-wikipedia-org-9224 141 17 II II NNP en-wikipedia-org-9224 141 18 MHC MHC NNP en-wikipedia-org-9224 141 19 molecules molecule NNS en-wikipedia-org-9224 141 20 . . . en-wikipedia-org-9224 142 1 The the DT en-wikipedia-org-9224 142 2 MHC MHC NNP en-wikipedia-org-9224 142 3 : : : en-wikipedia-org-9224 142 4 antigen antigen NNP en-wikipedia-org-9224 142 5 complex complex NN en-wikipedia-org-9224 142 6 is be VBZ en-wikipedia-org-9224 142 7 also also RB en-wikipedia-org-9224 142 8 recognized recognize VBN en-wikipedia-org-9224 142 9 by by IN en-wikipedia-org-9224 142 10 the the DT en-wikipedia-org-9224 142 11 helper helper NN en-wikipedia-org-9224 142 12 cell cell NN en-wikipedia-org-9224 142 13 's 's POS en-wikipedia-org-9224 142 14 CD4 CD4 NNP en-wikipedia-org-9224 142 15 co co NN en-wikipedia-org-9224 142 16 - - NN en-wikipedia-org-9224 142 17 receptor receptor NN en-wikipedia-org-9224 142 18 , , , en-wikipedia-org-9224 142 19 which which WDT en-wikipedia-org-9224 142 20 recruits recruit VBZ en-wikipedia-org-9224 142 21 molecules molecule NNS en-wikipedia-org-9224 142 22 inside inside IN en-wikipedia-org-9224 142 23 the the DT en-wikipedia-org-9224 142 24 T T NNP en-wikipedia-org-9224 142 25 cell cell NN en-wikipedia-org-9224 142 26 ( ( -LRB- en-wikipedia-org-9224 142 27 such such JJ en-wikipedia-org-9224 142 28 as as IN en-wikipedia-org-9224 142 29 Lck Lck NNP en-wikipedia-org-9224 142 30 ) ) -RRB- en-wikipedia-org-9224 142 31 that that WDT en-wikipedia-org-9224 142 32 are be VBP en-wikipedia-org-9224 142 33 responsible responsible JJ en-wikipedia-org-9224 142 34 for for IN en-wikipedia-org-9224 142 35 the the DT en-wikipedia-org-9224 142 36 T T NNP en-wikipedia-org-9224 142 37 cell cell NN en-wikipedia-org-9224 142 38 's 's POS en-wikipedia-org-9224 142 39 activation activation NN en-wikipedia-org-9224 142 40 . . . en-wikipedia-org-9224 143 1 Helper helper NN en-wikipedia-org-9224 143 2 T t NN en-wikipedia-org-9224 143 3 cells cell NNS en-wikipedia-org-9224 143 4 have have VBP en-wikipedia-org-9224 143 5 a a DT en-wikipedia-org-9224 143 6 weaker weak JJR en-wikipedia-org-9224 143 7 association association NN en-wikipedia-org-9224 143 8 with with IN en-wikipedia-org-9224 143 9 the the DT en-wikipedia-org-9224 143 10 MHC MHC NNP en-wikipedia-org-9224 143 11 : : : en-wikipedia-org-9224 143 12 antigen antigen NN en-wikipedia-org-9224 143 13 complex complex NN en-wikipedia-org-9224 143 14 than than IN en-wikipedia-org-9224 143 15 observed observe VBN en-wikipedia-org-9224 143 16 for for IN en-wikipedia-org-9224 143 17 killer killer NN en-wikipedia-org-9224 143 18 T T NNP en-wikipedia-org-9224 143 19 cells cell NNS en-wikipedia-org-9224 143 20 , , , en-wikipedia-org-9224 143 21 meaning mean VBG en-wikipedia-org-9224 143 22 many many JJ en-wikipedia-org-9224 143 23 receptors receptor NNS en-wikipedia-org-9224 143 24 ( ( -LRB- en-wikipedia-org-9224 143 25 around around RB en-wikipedia-org-9224 143 26 200–300 200–300 CD en-wikipedia-org-9224 143 27 ) ) -RRB- en-wikipedia-org-9224 143 28 on on IN en-wikipedia-org-9224 143 29 the the DT en-wikipedia-org-9224 143 30 helper helper NN en-wikipedia-org-9224 143 31 T T NNP en-wikipedia-org-9224 143 32 cell cell NN en-wikipedia-org-9224 143 33 must must MD en-wikipedia-org-9224 143 34 be be VB en-wikipedia-org-9224 143 35 bound bind VBN en-wikipedia-org-9224 143 36 by by IN en-wikipedia-org-9224 143 37 an an DT en-wikipedia-org-9224 143 38 MHC MHC NNP en-wikipedia-org-9224 143 39 : : : en-wikipedia-org-9224 143 40 antigen antigen NN en-wikipedia-org-9224 143 41 to to TO en-wikipedia-org-9224 143 42 activate activate VB en-wikipedia-org-9224 143 43 the the DT en-wikipedia-org-9224 143 44 helper helper NN en-wikipedia-org-9224 143 45 cell cell NN en-wikipedia-org-9224 143 46 , , , en-wikipedia-org-9224 143 47 while while IN en-wikipedia-org-9224 143 48 killer killer NN en-wikipedia-org-9224 143 49 T t NN en-wikipedia-org-9224 143 50 cells cell NNS en-wikipedia-org-9224 143 51 can can MD en-wikipedia-org-9224 143 52 be be VB en-wikipedia-org-9224 143 53 activated activate VBN en-wikipedia-org-9224 143 54 by by IN en-wikipedia-org-9224 143 55 engagement engagement NN en-wikipedia-org-9224 143 56 of of IN en-wikipedia-org-9224 143 57 a a DT en-wikipedia-org-9224 143 58 single single JJ en-wikipedia-org-9224 143 59 MHC MHC NNP en-wikipedia-org-9224 143 60 : : : en-wikipedia-org-9224 143 61 antigen antigen NNP en-wikipedia-org-9224 143 62 molecule molecule NN en-wikipedia-org-9224 143 63 . . . en-wikipedia-org-9224 144 1 Helper helper NN en-wikipedia-org-9224 144 2 T T NNP en-wikipedia-org-9224 144 3 cell cell NN en-wikipedia-org-9224 144 4 activation activation NN en-wikipedia-org-9224 144 5 also also RB en-wikipedia-org-9224 144 6 requires require VBZ en-wikipedia-org-9224 144 7 longer long JJR en-wikipedia-org-9224 144 8 duration duration NN en-wikipedia-org-9224 144 9 of of IN en-wikipedia-org-9224 144 10 engagement engagement NN en-wikipedia-org-9224 144 11 with with IN en-wikipedia-org-9224 144 12 an an DT en-wikipedia-org-9224 144 13 antigen antigen NN en-wikipedia-org-9224 144 14 - - HYPH en-wikipedia-org-9224 144 15 presenting present VBG en-wikipedia-org-9224 144 16 cell cell NN en-wikipedia-org-9224 144 17 . . . en-wikipedia-org-9224 145 1 [ [ -LRB- en-wikipedia-org-9224 145 2 67 67 CD en-wikipedia-org-9224 145 3 ] ] -RRB- en-wikipedia-org-9224 145 4 The the DT en-wikipedia-org-9224 145 5 activation activation NN en-wikipedia-org-9224 145 6 of of IN en-wikipedia-org-9224 145 7 a a DT en-wikipedia-org-9224 145 8 resting rest VBG en-wikipedia-org-9224 145 9 helper helper NN en-wikipedia-org-9224 145 10 T T NNP en-wikipedia-org-9224 145 11 cell cell NN en-wikipedia-org-9224 145 12 causes cause VBZ en-wikipedia-org-9224 145 13 it -PRON- PRP en-wikipedia-org-9224 145 14 to to TO en-wikipedia-org-9224 145 15 release release VB en-wikipedia-org-9224 145 16 cytokines cytokine NNS en-wikipedia-org-9224 145 17 that that WDT en-wikipedia-org-9224 145 18 influence influence VBP en-wikipedia-org-9224 145 19 the the DT en-wikipedia-org-9224 145 20 activity activity NN en-wikipedia-org-9224 145 21 of of IN en-wikipedia-org-9224 145 22 many many JJ en-wikipedia-org-9224 145 23 cell cell NN en-wikipedia-org-9224 145 24 types type NNS en-wikipedia-org-9224 145 25 . . . en-wikipedia-org-9224 146 1 Cytokine cytokine JJ en-wikipedia-org-9224 146 2 signals signal NNS en-wikipedia-org-9224 146 3 produced produce VBN en-wikipedia-org-9224 146 4 by by IN en-wikipedia-org-9224 146 5 helper helper NN en-wikipedia-org-9224 146 6 T t NN en-wikipedia-org-9224 146 7 cells cell NNS en-wikipedia-org-9224 146 8 enhance enhance VBP en-wikipedia-org-9224 146 9 the the DT en-wikipedia-org-9224 146 10 microbicidal microbicidal JJ en-wikipedia-org-9224 146 11 function function NN en-wikipedia-org-9224 146 12 of of IN en-wikipedia-org-9224 146 13 macrophages macrophage NNS en-wikipedia-org-9224 146 14 and and CC en-wikipedia-org-9224 146 15 the the DT en-wikipedia-org-9224 146 16 activity activity NN en-wikipedia-org-9224 146 17 of of IN en-wikipedia-org-9224 146 18 killer killer NN en-wikipedia-org-9224 146 19 T T NNP en-wikipedia-org-9224 146 20 cells cell NNS en-wikipedia-org-9224 146 21 . . . en-wikipedia-org-9224 147 1 [ [ -LRB- en-wikipedia-org-9224 147 2 68 68 CD en-wikipedia-org-9224 147 3 ] ] -RRB- en-wikipedia-org-9224 147 4 In in IN en-wikipedia-org-9224 147 5 addition addition NN en-wikipedia-org-9224 147 6 , , , en-wikipedia-org-9224 147 7 helper helper NN en-wikipedia-org-9224 147 8 T T NNP en-wikipedia-org-9224 147 9 cell cell NN en-wikipedia-org-9224 147 10 activation activation NN en-wikipedia-org-9224 147 11 causes cause VBZ en-wikipedia-org-9224 147 12 an an DT en-wikipedia-org-9224 147 13 upregulation upregulation NN en-wikipedia-org-9224 147 14 of of IN en-wikipedia-org-9224 147 15 molecules molecule NNS en-wikipedia-org-9224 147 16 expressed express VBN en-wikipedia-org-9224 147 17 on on IN en-wikipedia-org-9224 147 18 the the DT en-wikipedia-org-9224 147 19 T T NNP en-wikipedia-org-9224 147 20 cell cell NN en-wikipedia-org-9224 147 21 's 's POS en-wikipedia-org-9224 147 22 surface surface NN en-wikipedia-org-9224 147 23 , , , en-wikipedia-org-9224 147 24 such such JJ en-wikipedia-org-9224 147 25 as as IN en-wikipedia-org-9224 147 26 CD40 CD40 NNP en-wikipedia-org-9224 147 27 ligand ligand NN en-wikipedia-org-9224 147 28 ( ( -LRB- en-wikipedia-org-9224 147 29 also also RB en-wikipedia-org-9224 147 30 called call VBN en-wikipedia-org-9224 147 31 CD154 CD154 NNP en-wikipedia-org-9224 147 32 ) ) -RRB- en-wikipedia-org-9224 147 33 , , , en-wikipedia-org-9224 147 34 which which WDT en-wikipedia-org-9224 147 35 provide provide VBP en-wikipedia-org-9224 147 36 extra extra JJ en-wikipedia-org-9224 147 37 stimulatory stimulatory JJ en-wikipedia-org-9224 147 38 signals signal NNS en-wikipedia-org-9224 147 39 typically typically RB en-wikipedia-org-9224 147 40 required require VBN en-wikipedia-org-9224 147 41 to to TO en-wikipedia-org-9224 147 42 activate activate VB en-wikipedia-org-9224 147 43 antibody antibody NN en-wikipedia-org-9224 147 44 - - HYPH en-wikipedia-org-9224 147 45 producing produce VBG en-wikipedia-org-9224 147 46 B b NN en-wikipedia-org-9224 147 47 cells cell NNS en-wikipedia-org-9224 147 48 . . . en-wikipedia-org-9224 148 1 [ [ -LRB- en-wikipedia-org-9224 148 2 69 69 CD en-wikipedia-org-9224 148 3 ] ] -RRB- en-wikipedia-org-9224 148 4 Gamma Gamma NNP en-wikipedia-org-9224 148 5 delta delta NN en-wikipedia-org-9224 148 6 T T NNP en-wikipedia-org-9224 148 7 cells[edit cells[edit NN en-wikipedia-org-9224 148 8 ] ] -RRB- en-wikipedia-org-9224 148 9 Gamma Gamma NNP en-wikipedia-org-9224 148 10 delta delta NN en-wikipedia-org-9224 148 11 T T NNP en-wikipedia-org-9224 148 12 cells cell NNS en-wikipedia-org-9224 148 13 ( ( -LRB- en-wikipedia-org-9224 148 14 γδ γδ CC en-wikipedia-org-9224 148 15 T T NNP en-wikipedia-org-9224 148 16 cells cell NNS en-wikipedia-org-9224 148 17 ) ) -RRB- en-wikipedia-org-9224 148 18 possess possess VBP en-wikipedia-org-9224 148 19 an an DT en-wikipedia-org-9224 148 20 alternative alternative JJ en-wikipedia-org-9224 148 21 T t NN en-wikipedia-org-9224 148 22 - - HYPH en-wikipedia-org-9224 148 23 cell cell NN en-wikipedia-org-9224 148 24 receptor receptor NN en-wikipedia-org-9224 148 25 ( ( -LRB- en-wikipedia-org-9224 148 26 TCR TCR NNP en-wikipedia-org-9224 148 27 ) ) -RRB- en-wikipedia-org-9224 148 28 as as IN en-wikipedia-org-9224 148 29 opposed oppose VBN en-wikipedia-org-9224 148 30 to to IN en-wikipedia-org-9224 148 31 CD4 CD4 NNP en-wikipedia-org-9224 148 32 + + NNPS en-wikipedia-org-9224 148 33 and and CC en-wikipedia-org-9224 148 34 CD8 CD8 NNP en-wikipedia-org-9224 148 35 + + NFP en-wikipedia-org-9224 148 36 ( ( -LRB- en-wikipedia-org-9224 148 37 αβ αβ FW en-wikipedia-org-9224 148 38 ) ) -RRB- en-wikipedia-org-9224 148 39 T t NN en-wikipedia-org-9224 148 40 cells cell NNS en-wikipedia-org-9224 148 41 and and CC en-wikipedia-org-9224 148 42 share share VB en-wikipedia-org-9224 148 43 the the DT en-wikipedia-org-9224 148 44 characteristics characteristic NNS en-wikipedia-org-9224 148 45 of of IN en-wikipedia-org-9224 148 46 helper helper NN en-wikipedia-org-9224 148 47 T t NN en-wikipedia-org-9224 148 48 cells cell NNS en-wikipedia-org-9224 148 49 , , , en-wikipedia-org-9224 148 50 cytotoxic cytotoxic JJ en-wikipedia-org-9224 148 51 T t NN en-wikipedia-org-9224 148 52 cells cell NNS en-wikipedia-org-9224 148 53 and and CC en-wikipedia-org-9224 148 54 NK nk NN en-wikipedia-org-9224 148 55 cells cell NNS en-wikipedia-org-9224 148 56 . . . en-wikipedia-org-9224 149 1 The the DT en-wikipedia-org-9224 149 2 conditions condition NNS en-wikipedia-org-9224 149 3 that that WDT en-wikipedia-org-9224 149 4 produce produce VBP en-wikipedia-org-9224 149 5 responses response NNS en-wikipedia-org-9224 149 6 from from IN en-wikipedia-org-9224 149 7 γδ γδ NN en-wikipedia-org-9224 149 8 T T NNP en-wikipedia-org-9224 149 9 cells cell NNS en-wikipedia-org-9224 149 10 are be VBP en-wikipedia-org-9224 149 11 not not RB en-wikipedia-org-9224 149 12 fully fully RB en-wikipedia-org-9224 149 13 understood understand VBN en-wikipedia-org-9224 149 14 . . . en-wikipedia-org-9224 150 1 Like like IN en-wikipedia-org-9224 150 2 other other JJ en-wikipedia-org-9224 150 3 ' ' `` en-wikipedia-org-9224 150 4 unconventional unconventional JJ en-wikipedia-org-9224 150 5 ' ' '' en-wikipedia-org-9224 150 6 T T NNP en-wikipedia-org-9224 150 7 cell cell NN en-wikipedia-org-9224 150 8 subsets subset VBZ en-wikipedia-org-9224 150 9 bearing bear VBG en-wikipedia-org-9224 150 10 invariant invariant JJ en-wikipedia-org-9224 150 11 TCRs tcr NNS en-wikipedia-org-9224 150 12 , , , en-wikipedia-org-9224 150 13 such such JJ en-wikipedia-org-9224 150 14 as as IN en-wikipedia-org-9224 150 15 CD1d cd1d NN en-wikipedia-org-9224 150 16 - - HYPH en-wikipedia-org-9224 150 17 restricted restrict VBN en-wikipedia-org-9224 150 18 natural natural JJ en-wikipedia-org-9224 150 19 killer killer NN en-wikipedia-org-9224 150 20 T T NNP en-wikipedia-org-9224 150 21 cells cell NNS en-wikipedia-org-9224 150 22 , , , en-wikipedia-org-9224 150 23 γδ γδ CC en-wikipedia-org-9224 150 24 T t NN en-wikipedia-org-9224 150 25 cells cell NNS en-wikipedia-org-9224 150 26 straddle straddle VBP en-wikipedia-org-9224 150 27 the the DT en-wikipedia-org-9224 150 28 border border NN en-wikipedia-org-9224 150 29 between between IN en-wikipedia-org-9224 150 30 innate innate JJ en-wikipedia-org-9224 150 31 and and CC en-wikipedia-org-9224 150 32 adaptive adaptive JJ en-wikipedia-org-9224 150 33 immunity immunity NN en-wikipedia-org-9224 150 34 . . . en-wikipedia-org-9224 151 1 [ [ -LRB- en-wikipedia-org-9224 151 2 70 70 CD en-wikipedia-org-9224 151 3 ] ] -RRB- en-wikipedia-org-9224 151 4 On on IN en-wikipedia-org-9224 151 5 one one CD en-wikipedia-org-9224 151 6 hand hand NN en-wikipedia-org-9224 151 7 , , , en-wikipedia-org-9224 151 8 γδ γδ CC en-wikipedia-org-9224 151 9 T t NN en-wikipedia-org-9224 151 10 cells cell NNS en-wikipedia-org-9224 151 11 are be VBP en-wikipedia-org-9224 151 12 a a DT en-wikipedia-org-9224 151 13 component component NN en-wikipedia-org-9224 151 14 of of IN en-wikipedia-org-9224 151 15 adaptive adaptive JJ en-wikipedia-org-9224 151 16 immunity immunity NN en-wikipedia-org-9224 151 17 as as IN en-wikipedia-org-9224 151 18 they -PRON- PRP en-wikipedia-org-9224 151 19 rearrange rearrange VBP en-wikipedia-org-9224 151 20 TCR TCR NNP en-wikipedia-org-9224 151 21 genes gene NNS en-wikipedia-org-9224 151 22 to to TO en-wikipedia-org-9224 151 23 produce produce VB en-wikipedia-org-9224 151 24 receptor receptor NN en-wikipedia-org-9224 151 25 diversity diversity NN en-wikipedia-org-9224 151 26 and and CC en-wikipedia-org-9224 151 27 can can MD en-wikipedia-org-9224 151 28 also also RB en-wikipedia-org-9224 151 29 develop develop VB en-wikipedia-org-9224 151 30 a a DT en-wikipedia-org-9224 151 31 memory memory NN en-wikipedia-org-9224 151 32 phenotype phenotype NN en-wikipedia-org-9224 151 33 . . . en-wikipedia-org-9224 152 1 On on IN en-wikipedia-org-9224 152 2 the the DT en-wikipedia-org-9224 152 3 other other JJ en-wikipedia-org-9224 152 4 hand hand NN en-wikipedia-org-9224 152 5 , , , en-wikipedia-org-9224 152 6 the the DT en-wikipedia-org-9224 152 7 various various JJ en-wikipedia-org-9224 152 8 subsets subset NNS en-wikipedia-org-9224 152 9 are be VBP en-wikipedia-org-9224 152 10 also also RB en-wikipedia-org-9224 152 11 part part NN en-wikipedia-org-9224 152 12 of of IN en-wikipedia-org-9224 152 13 the the DT en-wikipedia-org-9224 152 14 innate innate JJ en-wikipedia-org-9224 152 15 immune immune JJ en-wikipedia-org-9224 152 16 system system NN en-wikipedia-org-9224 152 17 , , , en-wikipedia-org-9224 152 18 as as IN en-wikipedia-org-9224 152 19 restricted restrict VBN en-wikipedia-org-9224 152 20 TCR TCR NNP en-wikipedia-org-9224 152 21 or or CC en-wikipedia-org-9224 152 22 NK NK NNP en-wikipedia-org-9224 152 23 receptors receptor NNS en-wikipedia-org-9224 152 24 may may MD en-wikipedia-org-9224 152 25 be be VB en-wikipedia-org-9224 152 26 used use VBN en-wikipedia-org-9224 152 27 as as IN en-wikipedia-org-9224 152 28 pattern pattern NN en-wikipedia-org-9224 152 29 recognition recognition NN en-wikipedia-org-9224 152 30 receptors receptor NNS en-wikipedia-org-9224 152 31 . . . en-wikipedia-org-9224 153 1 For for IN en-wikipedia-org-9224 153 2 example example NN en-wikipedia-org-9224 153 3 , , , en-wikipedia-org-9224 153 4 large large JJ en-wikipedia-org-9224 153 5 numbers number NNS en-wikipedia-org-9224 153 6 of of IN en-wikipedia-org-9224 153 7 human human JJ en-wikipedia-org-9224 153 8 Vγ9 Vγ9 NNS en-wikipedia-org-9224 153 9 / / SYM en-wikipedia-org-9224 153 10 Vδ2 vδ2 JJ en-wikipedia-org-9224 153 11 T t NN en-wikipedia-org-9224 153 12 cells cell NNS en-wikipedia-org-9224 153 13 respond respond VBP en-wikipedia-org-9224 153 14 within within IN en-wikipedia-org-9224 153 15 hours hour NNS en-wikipedia-org-9224 153 16 to to IN en-wikipedia-org-9224 153 17 common common JJ en-wikipedia-org-9224 153 18 molecules molecule NNS en-wikipedia-org-9224 153 19 produced produce VBN en-wikipedia-org-9224 153 20 by by IN en-wikipedia-org-9224 153 21 microbes microbe NNS en-wikipedia-org-9224 153 22 , , , en-wikipedia-org-9224 153 23 and and CC en-wikipedia-org-9224 153 24 highly highly RB en-wikipedia-org-9224 153 25 restricted restrict VBN en-wikipedia-org-9224 153 26 Vδ1 vδ1 NN en-wikipedia-org-9224 153 27 + + CC en-wikipedia-org-9224 153 28 T t NN en-wikipedia-org-9224 153 29 cells cell NNS en-wikipedia-org-9224 153 30 in in IN en-wikipedia-org-9224 153 31 epithelia epithelia NNP en-wikipedia-org-9224 153 32 respond respond NNP en-wikipedia-org-9224 153 33 to to IN en-wikipedia-org-9224 153 34 stressed stressed JJ en-wikipedia-org-9224 153 35 epithelial epithelial JJ en-wikipedia-org-9224 153 36 cells cell NNS en-wikipedia-org-9224 153 37 . . . en-wikipedia-org-9224 154 1 [ [ -LRB- en-wikipedia-org-9224 154 2 56 56 CD en-wikipedia-org-9224 154 3 ] ] -RRB- en-wikipedia-org-9224 154 4 Humoral humoral NN en-wikipedia-org-9224 154 5 immune immune NN en-wikipedia-org-9224 154 6 response[edit response[edit , en-wikipedia-org-9224 154 7 ] ] -RRB- en-wikipedia-org-9224 154 8 An an DT en-wikipedia-org-9224 154 9 antibody antibody NN en-wikipedia-org-9224 154 10 is be VBZ en-wikipedia-org-9224 154 11 made make VBN en-wikipedia-org-9224 154 12 up up RP en-wikipedia-org-9224 154 13 of of IN en-wikipedia-org-9224 154 14 two two CD en-wikipedia-org-9224 154 15 heavy heavy JJ en-wikipedia-org-9224 154 16 chains chain NNS en-wikipedia-org-9224 154 17 and and CC en-wikipedia-org-9224 154 18 two two CD en-wikipedia-org-9224 154 19 light light JJ en-wikipedia-org-9224 154 20 chains chain NNS en-wikipedia-org-9224 154 21 . . . en-wikipedia-org-9224 155 1 The the DT en-wikipedia-org-9224 155 2 unique unique JJ en-wikipedia-org-9224 155 3 variable variable JJ en-wikipedia-org-9224 155 4 region region NN en-wikipedia-org-9224 155 5 allows allow VBZ en-wikipedia-org-9224 155 6 an an DT en-wikipedia-org-9224 155 7 antibody antibody NN en-wikipedia-org-9224 155 8 to to TO en-wikipedia-org-9224 155 9 recognize recognize VB en-wikipedia-org-9224 155 10 its -PRON- PRP$ en-wikipedia-org-9224 155 11 matching match VBG en-wikipedia-org-9224 155 12 antigen antigen NN en-wikipedia-org-9224 155 13 . . . en-wikipedia-org-9224 156 1 [ [ -LRB- en-wikipedia-org-9224 156 2 71 71 CD en-wikipedia-org-9224 156 3 ] ] -RRB- en-wikipedia-org-9224 156 4 A a DT en-wikipedia-org-9224 156 5 B B NNP en-wikipedia-org-9224 156 6 cell cell NN en-wikipedia-org-9224 156 7 identifies identifie NNS en-wikipedia-org-9224 156 8 pathogens pathogen VBZ en-wikipedia-org-9224 156 9 when when WRB en-wikipedia-org-9224 156 10 antibodies antibody NNS en-wikipedia-org-9224 156 11 on on IN en-wikipedia-org-9224 156 12 its -PRON- PRP$ en-wikipedia-org-9224 156 13 surface surface NN en-wikipedia-org-9224 156 14 bind bind NN en-wikipedia-org-9224 156 15 to to IN en-wikipedia-org-9224 156 16 a a DT en-wikipedia-org-9224 156 17 specific specific JJ en-wikipedia-org-9224 156 18 foreign foreign JJ en-wikipedia-org-9224 156 19 antigen antigen NN en-wikipedia-org-9224 156 20 . . . en-wikipedia-org-9224 157 1 [ [ -LRB- en-wikipedia-org-9224 157 2 72 72 CD en-wikipedia-org-9224 157 3 ] ] -RRB- en-wikipedia-org-9224 157 4 This this DT en-wikipedia-org-9224 157 5 antigen antigen NN en-wikipedia-org-9224 157 6 / / SYM en-wikipedia-org-9224 157 7 antibody antibody NN en-wikipedia-org-9224 157 8 complex complex NN en-wikipedia-org-9224 157 9 is be VBZ en-wikipedia-org-9224 157 10 taken take VBN en-wikipedia-org-9224 157 11 up up RP en-wikipedia-org-9224 157 12 by by IN en-wikipedia-org-9224 157 13 the the DT en-wikipedia-org-9224 157 14 B b NN en-wikipedia-org-9224 157 15 cell cell NN en-wikipedia-org-9224 157 16 and and CC en-wikipedia-org-9224 157 17 processed process VBN en-wikipedia-org-9224 157 18 by by IN en-wikipedia-org-9224 157 19 proteolysis proteolysis NN en-wikipedia-org-9224 157 20 into into IN en-wikipedia-org-9224 157 21 peptides peptide NNS en-wikipedia-org-9224 157 22 . . . en-wikipedia-org-9224 158 1 The the DT en-wikipedia-org-9224 158 2 B B NNP en-wikipedia-org-9224 158 3 cell cell NN en-wikipedia-org-9224 158 4 then then RB en-wikipedia-org-9224 158 5 displays display VBZ en-wikipedia-org-9224 158 6 these these DT en-wikipedia-org-9224 158 7 antigenic antigenic JJ en-wikipedia-org-9224 158 8 peptides peptide NNS en-wikipedia-org-9224 158 9 on on IN en-wikipedia-org-9224 158 10 its -PRON- PRP$ en-wikipedia-org-9224 158 11 surface surface NN en-wikipedia-org-9224 158 12 MHC MHC NNP en-wikipedia-org-9224 158 13 class class NN en-wikipedia-org-9224 158 14 II II NNP en-wikipedia-org-9224 158 15 molecules molecule NNS en-wikipedia-org-9224 158 16 . . . en-wikipedia-org-9224 159 1 This this DT en-wikipedia-org-9224 159 2 combination combination NN en-wikipedia-org-9224 159 3 of of IN en-wikipedia-org-9224 159 4 MHC MHC NNP en-wikipedia-org-9224 159 5 and and CC en-wikipedia-org-9224 159 6 antigen antigen NNP en-wikipedia-org-9224 159 7 attracts attract VBZ en-wikipedia-org-9224 159 8 a a DT en-wikipedia-org-9224 159 9 matching match VBG en-wikipedia-org-9224 159 10 helper helper NN en-wikipedia-org-9224 159 11 T T NNP en-wikipedia-org-9224 159 12 cell cell NN en-wikipedia-org-9224 159 13 , , , en-wikipedia-org-9224 159 14 which which WDT en-wikipedia-org-9224 159 15 releases release VBZ en-wikipedia-org-9224 159 16 lymphokines lymphokine NNS en-wikipedia-org-9224 159 17 and and CC en-wikipedia-org-9224 159 18 activates activate VBZ en-wikipedia-org-9224 159 19 the the DT en-wikipedia-org-9224 159 20 B B NNP en-wikipedia-org-9224 159 21 cell cell NN en-wikipedia-org-9224 159 22 . . . en-wikipedia-org-9224 160 1 [ [ -LRB- en-wikipedia-org-9224 160 2 73 73 CD en-wikipedia-org-9224 160 3 ] ] -RRB- en-wikipedia-org-9224 160 4 As as IN en-wikipedia-org-9224 160 5 the the DT en-wikipedia-org-9224 160 6 activated activate VBN en-wikipedia-org-9224 160 7 B B NNP en-wikipedia-org-9224 160 8 cell cell NN en-wikipedia-org-9224 160 9 then then RB en-wikipedia-org-9224 160 10 begins begin VBZ en-wikipedia-org-9224 160 11 to to TO en-wikipedia-org-9224 160 12 divide divide VB en-wikipedia-org-9224 160 13 , , , en-wikipedia-org-9224 160 14 its -PRON- PRP$ en-wikipedia-org-9224 160 15 offspring offspring NN en-wikipedia-org-9224 160 16 ( ( -LRB- en-wikipedia-org-9224 160 17 plasma plasma NN en-wikipedia-org-9224 160 18 cells cell NNS en-wikipedia-org-9224 160 19 ) ) -RRB- en-wikipedia-org-9224 160 20 secrete secrete JJ en-wikipedia-org-9224 160 21 millions million NNS en-wikipedia-org-9224 160 22 of of IN en-wikipedia-org-9224 160 23 copies copy NNS en-wikipedia-org-9224 160 24 of of IN en-wikipedia-org-9224 160 25 the the DT en-wikipedia-org-9224 160 26 antibody antibody NN en-wikipedia-org-9224 160 27 that that WDT en-wikipedia-org-9224 160 28 recognizes recognize VBZ en-wikipedia-org-9224 160 29 this this DT en-wikipedia-org-9224 160 30 antigen antigen NN en-wikipedia-org-9224 160 31 . . . en-wikipedia-org-9224 161 1 These these DT en-wikipedia-org-9224 161 2 antibodies antibody NNS en-wikipedia-org-9224 161 3 circulate circulate VBP en-wikipedia-org-9224 161 4 in in IN en-wikipedia-org-9224 161 5 blood blood NN en-wikipedia-org-9224 161 6 plasma plasma NN en-wikipedia-org-9224 161 7 and and CC en-wikipedia-org-9224 161 8 lymph lymph NN en-wikipedia-org-9224 161 9 , , , en-wikipedia-org-9224 161 10 bind bind NN en-wikipedia-org-9224 161 11 to to IN en-wikipedia-org-9224 161 12 pathogens pathogen NNS en-wikipedia-org-9224 161 13 expressing express VBG en-wikipedia-org-9224 161 14 the the DT en-wikipedia-org-9224 161 15 antigen antigen NN en-wikipedia-org-9224 161 16 and and CC en-wikipedia-org-9224 161 17 mark mark VB en-wikipedia-org-9224 161 18 them -PRON- PRP en-wikipedia-org-9224 161 19 for for IN en-wikipedia-org-9224 161 20 destruction destruction NN en-wikipedia-org-9224 161 21 by by IN en-wikipedia-org-9224 161 22 complement complement JJ en-wikipedia-org-9224 161 23 activation activation NN en-wikipedia-org-9224 161 24 or or CC en-wikipedia-org-9224 161 25 for for IN en-wikipedia-org-9224 161 26 uptake uptake NN en-wikipedia-org-9224 161 27 and and CC en-wikipedia-org-9224 161 28 destruction destruction NN en-wikipedia-org-9224 161 29 by by IN en-wikipedia-org-9224 161 30 phagocytes phagocyte NNS en-wikipedia-org-9224 161 31 . . . en-wikipedia-org-9224 162 1 Antibodies antibody NNS en-wikipedia-org-9224 162 2 can can MD en-wikipedia-org-9224 162 3 also also RB en-wikipedia-org-9224 162 4 neutralize neutralize VB en-wikipedia-org-9224 162 5 challenges challenge NNS en-wikipedia-org-9224 162 6 directly directly RB en-wikipedia-org-9224 162 7 , , , en-wikipedia-org-9224 162 8 by by IN en-wikipedia-org-9224 162 9 binding bind VBG en-wikipedia-org-9224 162 10 to to IN en-wikipedia-org-9224 162 11 bacterial bacterial JJ en-wikipedia-org-9224 162 12 toxins toxin NNS en-wikipedia-org-9224 162 13 or or CC en-wikipedia-org-9224 162 14 by by IN en-wikipedia-org-9224 162 15 interfering interfere VBG en-wikipedia-org-9224 162 16 with with IN en-wikipedia-org-9224 162 17 the the DT en-wikipedia-org-9224 162 18 receptors receptor NNS en-wikipedia-org-9224 162 19 that that WDT en-wikipedia-org-9224 162 20 viruses virus NNS en-wikipedia-org-9224 162 21 and and CC en-wikipedia-org-9224 162 22 bacteria bacteria NNS en-wikipedia-org-9224 162 23 use use VBP en-wikipedia-org-9224 162 24 to to TO en-wikipedia-org-9224 162 25 infect infect VB en-wikipedia-org-9224 162 26 cells cell NNS en-wikipedia-org-9224 162 27 . . . en-wikipedia-org-9224 163 1 [ [ -LRB- en-wikipedia-org-9224 163 2 74 74 CD en-wikipedia-org-9224 163 3 ] ] -RRB- en-wikipedia-org-9224 163 4 Newborn newborn JJ en-wikipedia-org-9224 163 5 infants infant NNS en-wikipedia-org-9224 163 6 have have VBP en-wikipedia-org-9224 163 7 no no DT en-wikipedia-org-9224 163 8 prior prior JJ en-wikipedia-org-9224 163 9 exposure exposure NN en-wikipedia-org-9224 163 10 to to IN en-wikipedia-org-9224 163 11 microbes microbe NNS en-wikipedia-org-9224 163 12 and and CC en-wikipedia-org-9224 163 13 are be VBP en-wikipedia-org-9224 163 14 particularly particularly RB en-wikipedia-org-9224 163 15 vulnerable vulnerable JJ en-wikipedia-org-9224 163 16 to to IN en-wikipedia-org-9224 163 17 infection infection NN en-wikipedia-org-9224 163 18 . . . en-wikipedia-org-9224 164 1 Several several JJ en-wikipedia-org-9224 164 2 layers layer NNS en-wikipedia-org-9224 164 3 of of IN en-wikipedia-org-9224 164 4 passive passive JJ en-wikipedia-org-9224 164 5 protection protection NN en-wikipedia-org-9224 164 6 are be VBP en-wikipedia-org-9224 164 7 provided provide VBN en-wikipedia-org-9224 164 8 by by IN en-wikipedia-org-9224 164 9 the the DT en-wikipedia-org-9224 164 10 mother mother NN en-wikipedia-org-9224 164 11 . . . en-wikipedia-org-9224 165 1 During during IN en-wikipedia-org-9224 165 2 pregnancy pregnancy NN en-wikipedia-org-9224 165 3 , , , en-wikipedia-org-9224 165 4 a a DT en-wikipedia-org-9224 165 5 particular particular JJ en-wikipedia-org-9224 165 6 type type NN en-wikipedia-org-9224 165 7 of of IN en-wikipedia-org-9224 165 8 antibody antibody NN en-wikipedia-org-9224 165 9 , , , en-wikipedia-org-9224 165 10 called call VBN en-wikipedia-org-9224 165 11 IgG IgG NNP en-wikipedia-org-9224 165 12 , , , en-wikipedia-org-9224 165 13 is be VBZ en-wikipedia-org-9224 165 14 transported transport VBN en-wikipedia-org-9224 165 15 from from IN en-wikipedia-org-9224 165 16 mother mother NN en-wikipedia-org-9224 165 17 to to IN en-wikipedia-org-9224 165 18 baby baby NN en-wikipedia-org-9224 165 19 directly directly RB en-wikipedia-org-9224 165 20 through through IN en-wikipedia-org-9224 165 21 the the DT en-wikipedia-org-9224 165 22 placenta placenta NN en-wikipedia-org-9224 165 23 , , , en-wikipedia-org-9224 165 24 so so RB en-wikipedia-org-9224 165 25 human human JJ en-wikipedia-org-9224 165 26 babies baby NNS en-wikipedia-org-9224 165 27 have have VBP en-wikipedia-org-9224 165 28 high high JJ en-wikipedia-org-9224 165 29 levels level NNS en-wikipedia-org-9224 165 30 of of IN en-wikipedia-org-9224 165 31 antibodies antibody NNS en-wikipedia-org-9224 165 32 even even RB en-wikipedia-org-9224 165 33 at at IN en-wikipedia-org-9224 165 34 birth birth NN en-wikipedia-org-9224 165 35 , , , en-wikipedia-org-9224 165 36 with with IN en-wikipedia-org-9224 165 37 the the DT en-wikipedia-org-9224 165 38 same same JJ en-wikipedia-org-9224 165 39 range range NN en-wikipedia-org-9224 165 40 of of IN en-wikipedia-org-9224 165 41 antigen antigen NNP en-wikipedia-org-9224 165 42 specificities specificity NNS en-wikipedia-org-9224 165 43 as as IN en-wikipedia-org-9224 165 44 their -PRON- PRP$ en-wikipedia-org-9224 165 45 mother mother NN en-wikipedia-org-9224 165 46 . . . en-wikipedia-org-9224 166 1 [ [ -LRB- en-wikipedia-org-9224 166 2 75 75 CD en-wikipedia-org-9224 166 3 ] ] -RRB- en-wikipedia-org-9224 166 4 Breast breast NN en-wikipedia-org-9224 166 5 milk milk NN en-wikipedia-org-9224 166 6 or or CC en-wikipedia-org-9224 166 7 colostrum colostrum NN en-wikipedia-org-9224 166 8 also also RB en-wikipedia-org-9224 166 9 contains contain VBZ en-wikipedia-org-9224 166 10 antibodies antibody NNS en-wikipedia-org-9224 166 11 that that WDT en-wikipedia-org-9224 166 12 are be VBP en-wikipedia-org-9224 166 13 transferred transfer VBN en-wikipedia-org-9224 166 14 to to IN en-wikipedia-org-9224 166 15 the the DT en-wikipedia-org-9224 166 16 gut gut NN en-wikipedia-org-9224 166 17 of of IN en-wikipedia-org-9224 166 18 the the DT en-wikipedia-org-9224 166 19 infant infant NN en-wikipedia-org-9224 166 20 and and CC en-wikipedia-org-9224 166 21 protect protect VB en-wikipedia-org-9224 166 22 against against IN en-wikipedia-org-9224 166 23 bacterial bacterial JJ en-wikipedia-org-9224 166 24 infections infection NNS en-wikipedia-org-9224 166 25 until until IN en-wikipedia-org-9224 166 26 the the DT en-wikipedia-org-9224 166 27 newborn newborn JJ en-wikipedia-org-9224 166 28 can can MD en-wikipedia-org-9224 166 29 synthesize synthesize VB en-wikipedia-org-9224 166 30 its -PRON- PRP$ en-wikipedia-org-9224 166 31 own own JJ en-wikipedia-org-9224 166 32 antibodies antibody NNS en-wikipedia-org-9224 166 33 . . . en-wikipedia-org-9224 167 1 [ [ -LRB- en-wikipedia-org-9224 167 2 76 76 CD en-wikipedia-org-9224 167 3 ] ] -RRB- en-wikipedia-org-9224 167 4 This this DT en-wikipedia-org-9224 167 5 is be VBZ en-wikipedia-org-9224 167 6 passive passive JJ en-wikipedia-org-9224 167 7 immunity immunity NN en-wikipedia-org-9224 167 8 because because IN en-wikipedia-org-9224 167 9 the the DT en-wikipedia-org-9224 167 10 fetus fetus NN en-wikipedia-org-9224 167 11 does do VBZ en-wikipedia-org-9224 167 12 not not RB en-wikipedia-org-9224 167 13 actually actually RB en-wikipedia-org-9224 167 14 make make VB en-wikipedia-org-9224 167 15 any any DT en-wikipedia-org-9224 167 16 memory memory NN en-wikipedia-org-9224 167 17 cells cell NNS en-wikipedia-org-9224 167 18 or or CC en-wikipedia-org-9224 167 19 antibodies antibody NNS en-wikipedia-org-9224 167 20 — — : en-wikipedia-org-9224 167 21 it -PRON- PRP en-wikipedia-org-9224 167 22 only only RB en-wikipedia-org-9224 167 23 borrows borrow VBZ en-wikipedia-org-9224 167 24 them -PRON- PRP en-wikipedia-org-9224 167 25 . . . en-wikipedia-org-9224 168 1 This this DT en-wikipedia-org-9224 168 2 passive passive JJ en-wikipedia-org-9224 168 3 immunity immunity NN en-wikipedia-org-9224 168 4 is be VBZ en-wikipedia-org-9224 168 5 usually usually RB en-wikipedia-org-9224 168 6 short short JJ en-wikipedia-org-9224 168 7 - - HYPH en-wikipedia-org-9224 168 8 term term NN en-wikipedia-org-9224 168 9 , , , en-wikipedia-org-9224 168 10 lasting last VBG en-wikipedia-org-9224 168 11 from from IN en-wikipedia-org-9224 168 12 a a DT en-wikipedia-org-9224 168 13 few few JJ en-wikipedia-org-9224 168 14 days day NNS en-wikipedia-org-9224 168 15 up up IN en-wikipedia-org-9224 168 16 to to IN en-wikipedia-org-9224 168 17 several several JJ en-wikipedia-org-9224 168 18 months month NNS en-wikipedia-org-9224 168 19 . . . en-wikipedia-org-9224 169 1 In in IN en-wikipedia-org-9224 169 2 medicine medicine NN en-wikipedia-org-9224 169 3 , , , en-wikipedia-org-9224 169 4 protective protective JJ en-wikipedia-org-9224 169 5 passive passive JJ en-wikipedia-org-9224 169 6 immunity immunity NN en-wikipedia-org-9224 169 7 can can MD en-wikipedia-org-9224 169 8 also also RB en-wikipedia-org-9224 169 9 be be VB en-wikipedia-org-9224 169 10 transferred transfer VBN en-wikipedia-org-9224 169 11 artificially artificially RB en-wikipedia-org-9224 169 12 from from IN en-wikipedia-org-9224 169 13 one one CD en-wikipedia-org-9224 169 14 individual individual NN en-wikipedia-org-9224 169 15 to to IN en-wikipedia-org-9224 169 16 another another DT en-wikipedia-org-9224 169 17 . . . en-wikipedia-org-9224 170 1 [ [ -LRB- en-wikipedia-org-9224 170 2 77 77 CD en-wikipedia-org-9224 170 3 ] ] -RRB- en-wikipedia-org-9224 170 4 Immunological immunological JJ en-wikipedia-org-9224 170 5 memory[edit memory[edit NFP en-wikipedia-org-9224 170 6 ] ] -RRB- en-wikipedia-org-9224 170 7 Further further JJ en-wikipedia-org-9224 170 8 information information NN en-wikipedia-org-9224 170 9 : : : en-wikipedia-org-9224 170 10 Immunity immunity NN en-wikipedia-org-9224 170 11 ( ( -LRB- en-wikipedia-org-9224 170 12 medical medical JJ en-wikipedia-org-9224 170 13 ) ) -RRB- en-wikipedia-org-9224 170 14 When when WRB en-wikipedia-org-9224 170 15 B b NN en-wikipedia-org-9224 170 16 cells cell NNS en-wikipedia-org-9224 170 17 and and CC en-wikipedia-org-9224 170 18 T t NN en-wikipedia-org-9224 170 19 cells cell NNS en-wikipedia-org-9224 170 20 are be VBP en-wikipedia-org-9224 170 21 activated activate VBN en-wikipedia-org-9224 170 22 and and CC en-wikipedia-org-9224 170 23 begin begin VB en-wikipedia-org-9224 170 24 to to TO en-wikipedia-org-9224 170 25 replicate replicate VB en-wikipedia-org-9224 170 26 , , , en-wikipedia-org-9224 170 27 some some DT en-wikipedia-org-9224 170 28 of of IN en-wikipedia-org-9224 170 29 their -PRON- PRP$ en-wikipedia-org-9224 170 30 offspring offspring NN en-wikipedia-org-9224 170 31 become become VBP en-wikipedia-org-9224 170 32 long long RB en-wikipedia-org-9224 170 33 - - HYPH en-wikipedia-org-9224 170 34 lived live VBN en-wikipedia-org-9224 170 35 memory memory NN en-wikipedia-org-9224 170 36 cells cell NNS en-wikipedia-org-9224 170 37 . . . en-wikipedia-org-9224 171 1 Throughout throughout IN en-wikipedia-org-9224 171 2 the the DT en-wikipedia-org-9224 171 3 lifetime lifetime NN en-wikipedia-org-9224 171 4 of of IN en-wikipedia-org-9224 171 5 an an DT en-wikipedia-org-9224 171 6 animal animal NN en-wikipedia-org-9224 171 7 , , , en-wikipedia-org-9224 171 8 these these DT en-wikipedia-org-9224 171 9 memory memory NN en-wikipedia-org-9224 171 10 cells cell NNS en-wikipedia-org-9224 171 11 remember remember VBP en-wikipedia-org-9224 171 12 each each DT en-wikipedia-org-9224 171 13 specific specific JJ en-wikipedia-org-9224 171 14 pathogen pathogen NN en-wikipedia-org-9224 171 15 encountered encounter VBN en-wikipedia-org-9224 171 16 and and CC en-wikipedia-org-9224 171 17 can can MD en-wikipedia-org-9224 171 18 mount mount VB en-wikipedia-org-9224 171 19 a a DT en-wikipedia-org-9224 171 20 strong strong JJ en-wikipedia-org-9224 171 21 response response NN en-wikipedia-org-9224 171 22 if if IN en-wikipedia-org-9224 171 23 the the DT en-wikipedia-org-9224 171 24 pathogen pathogen NN en-wikipedia-org-9224 171 25 is be VBZ en-wikipedia-org-9224 171 26 detected detect VBN en-wikipedia-org-9224 171 27 again again RB en-wikipedia-org-9224 171 28 . . . en-wikipedia-org-9224 172 1 This this DT en-wikipedia-org-9224 172 2 is be VBZ en-wikipedia-org-9224 172 3 " " `` en-wikipedia-org-9224 172 4 adaptive adaptive JJ en-wikipedia-org-9224 172 5 " " '' en-wikipedia-org-9224 172 6 because because IN en-wikipedia-org-9224 172 7 it -PRON- PRP en-wikipedia-org-9224 172 8 occurs occur VBZ en-wikipedia-org-9224 172 9 during during IN en-wikipedia-org-9224 172 10 the the DT en-wikipedia-org-9224 172 11 lifetime lifetime NN en-wikipedia-org-9224 172 12 of of IN en-wikipedia-org-9224 172 13 an an DT en-wikipedia-org-9224 172 14 individual individual NN en-wikipedia-org-9224 172 15 as as IN en-wikipedia-org-9224 172 16 an an DT en-wikipedia-org-9224 172 17 adaptation adaptation NN en-wikipedia-org-9224 172 18 to to IN en-wikipedia-org-9224 172 19 infection infection NN en-wikipedia-org-9224 172 20 with with IN en-wikipedia-org-9224 172 21 that that DT en-wikipedia-org-9224 172 22 pathogen pathogen NN en-wikipedia-org-9224 172 23 and and CC en-wikipedia-org-9224 172 24 prepares prepare VBZ en-wikipedia-org-9224 172 25 the the DT en-wikipedia-org-9224 172 26 immune immune JJ en-wikipedia-org-9224 172 27 system system NN en-wikipedia-org-9224 172 28 for for IN en-wikipedia-org-9224 172 29 future future JJ en-wikipedia-org-9224 172 30 challenges challenge NNS en-wikipedia-org-9224 172 31 . . . en-wikipedia-org-9224 173 1 Immunological immunological JJ en-wikipedia-org-9224 173 2 memory memory NN en-wikipedia-org-9224 173 3 can can MD en-wikipedia-org-9224 173 4 be be VB en-wikipedia-org-9224 173 5 in in IN en-wikipedia-org-9224 173 6 the the DT en-wikipedia-org-9224 173 7 form form NN en-wikipedia-org-9224 173 8 of of IN en-wikipedia-org-9224 173 9 either either DT en-wikipedia-org-9224 173 10 passive passive JJ en-wikipedia-org-9224 173 11 short short JJ en-wikipedia-org-9224 173 12 - - HYPH en-wikipedia-org-9224 173 13 term term NN en-wikipedia-org-9224 173 14 memory memory NN en-wikipedia-org-9224 173 15 or or CC en-wikipedia-org-9224 173 16 active active JJ en-wikipedia-org-9224 173 17 long long JJ en-wikipedia-org-9224 173 18 - - HYPH en-wikipedia-org-9224 173 19 term term NN en-wikipedia-org-9224 173 20 memory memory NN en-wikipedia-org-9224 173 21 . . . en-wikipedia-org-9224 174 1 [ [ -LRB- en-wikipedia-org-9224 174 2 78 78 CD en-wikipedia-org-9224 174 3 ] ] -RRB- en-wikipedia-org-9224 174 4 Physiological physiological JJ en-wikipedia-org-9224 174 5 regulation[edit regulation[edit CD en-wikipedia-org-9224 174 6 ] ] -RRB- en-wikipedia-org-9224 174 7 The the DT en-wikipedia-org-9224 174 8 time time NN en-wikipedia-org-9224 174 9 - - HYPH en-wikipedia-org-9224 174 10 course course NN en-wikipedia-org-9224 174 11 of of IN en-wikipedia-org-9224 174 12 an an DT en-wikipedia-org-9224 174 13 immune immune JJ en-wikipedia-org-9224 174 14 response response NN en-wikipedia-org-9224 174 15 begins begin VBZ en-wikipedia-org-9224 174 16 with with IN en-wikipedia-org-9224 174 17 the the DT en-wikipedia-org-9224 174 18 initial initial JJ en-wikipedia-org-9224 174 19 pathogen pathogen NN en-wikipedia-org-9224 174 20 encounter encounter NN en-wikipedia-org-9224 174 21 , , , en-wikipedia-org-9224 174 22 ( ( -LRB- en-wikipedia-org-9224 174 23 or or CC en-wikipedia-org-9224 174 24 initial initial JJ en-wikipedia-org-9224 174 25 vaccination vaccination NN en-wikipedia-org-9224 174 26 ) ) -RRB- en-wikipedia-org-9224 174 27 and and CC en-wikipedia-org-9224 174 28 leads lead VBZ en-wikipedia-org-9224 174 29 to to IN en-wikipedia-org-9224 174 30 the the DT en-wikipedia-org-9224 174 31 formation formation NN en-wikipedia-org-9224 174 32 and and CC en-wikipedia-org-9224 174 33 maintenance maintenance NN en-wikipedia-org-9224 174 34 of of IN en-wikipedia-org-9224 174 35 active active JJ en-wikipedia-org-9224 174 36 immunological immunological JJ en-wikipedia-org-9224 174 37 memory memory NN en-wikipedia-org-9224 174 38 . . . en-wikipedia-org-9224 175 1 The the DT en-wikipedia-org-9224 175 2 immune immune JJ en-wikipedia-org-9224 175 3 system system NN en-wikipedia-org-9224 175 4 is be VBZ en-wikipedia-org-9224 175 5 involved involve VBN en-wikipedia-org-9224 175 6 in in IN en-wikipedia-org-9224 175 7 many many JJ en-wikipedia-org-9224 175 8 aspects aspect NNS en-wikipedia-org-9224 175 9 of of IN en-wikipedia-org-9224 175 10 physiological physiological JJ en-wikipedia-org-9224 175 11 regulation regulation NN en-wikipedia-org-9224 175 12 in in IN en-wikipedia-org-9224 175 13 the the DT en-wikipedia-org-9224 175 14 body body NN en-wikipedia-org-9224 175 15 . . . en-wikipedia-org-9224 176 1 The the DT en-wikipedia-org-9224 176 2 immune immune JJ en-wikipedia-org-9224 176 3 system system NN en-wikipedia-org-9224 176 4 interacts interact VBZ en-wikipedia-org-9224 176 5 intimately intimately RB en-wikipedia-org-9224 176 6 with with IN en-wikipedia-org-9224 176 7 other other JJ en-wikipedia-org-9224 176 8 systems system NNS en-wikipedia-org-9224 176 9 , , , en-wikipedia-org-9224 176 10 such such JJ en-wikipedia-org-9224 176 11 as as IN en-wikipedia-org-9224 176 12 the the DT en-wikipedia-org-9224 176 13 endocrine endocrine NN en-wikipedia-org-9224 176 14 [ [ -LRB- en-wikipedia-org-9224 176 15 79][80 79][80 CD en-wikipedia-org-9224 176 16 ] ] -RRB- en-wikipedia-org-9224 176 17 and and CC en-wikipedia-org-9224 176 18 the the DT en-wikipedia-org-9224 176 19 nervous nervous JJ en-wikipedia-org-9224 176 20 [ [ -LRB- en-wikipedia-org-9224 176 21 81][82][83 81][82][83 CD en-wikipedia-org-9224 176 22 ] ] -RRB- en-wikipedia-org-9224 176 23 systems system NNS en-wikipedia-org-9224 176 24 . . . en-wikipedia-org-9224 177 1 The the DT en-wikipedia-org-9224 177 2 immune immune JJ en-wikipedia-org-9224 177 3 system system NN en-wikipedia-org-9224 177 4 also also RB en-wikipedia-org-9224 177 5 plays play VBZ en-wikipedia-org-9224 177 6 a a DT en-wikipedia-org-9224 177 7 crucial crucial JJ en-wikipedia-org-9224 177 8 role role NN en-wikipedia-org-9224 177 9 in in IN en-wikipedia-org-9224 177 10 embryogenesis embryogenesis NN en-wikipedia-org-9224 177 11 ( ( -LRB- en-wikipedia-org-9224 177 12 development development NN en-wikipedia-org-9224 177 13 of of IN en-wikipedia-org-9224 177 14 the the DT en-wikipedia-org-9224 177 15 embryo embryo NN en-wikipedia-org-9224 177 16 ) ) -RRB- en-wikipedia-org-9224 177 17 , , , en-wikipedia-org-9224 177 18 as as RB en-wikipedia-org-9224 177 19 well well RB en-wikipedia-org-9224 177 20 as as IN en-wikipedia-org-9224 177 21 in in IN en-wikipedia-org-9224 177 22 tissue tissue NN en-wikipedia-org-9224 177 23 repair repair NN en-wikipedia-org-9224 177 24 and and CC en-wikipedia-org-9224 177 25 regeneration regeneration NN en-wikipedia-org-9224 177 26 . . . en-wikipedia-org-9224 178 1 [ [ -LRB- en-wikipedia-org-9224 178 2 84 84 CD en-wikipedia-org-9224 178 3 ] ] -RRB- en-wikipedia-org-9224 178 4 Hormones[edit hormones[edit NN en-wikipedia-org-9224 178 5 ] ] -RRB- en-wikipedia-org-9224 178 6 Hormones hormone NNS en-wikipedia-org-9224 178 7 can can MD en-wikipedia-org-9224 178 8 act act VB en-wikipedia-org-9224 178 9 as as IN en-wikipedia-org-9224 178 10 immunomodulators immunomodulator NNS en-wikipedia-org-9224 178 11 , , , en-wikipedia-org-9224 178 12 altering alter VBG en-wikipedia-org-9224 178 13 the the DT en-wikipedia-org-9224 178 14 sensitivity sensitivity NN en-wikipedia-org-9224 178 15 of of IN en-wikipedia-org-9224 178 16 the the DT en-wikipedia-org-9224 178 17 immune immune JJ en-wikipedia-org-9224 178 18 system system NN en-wikipedia-org-9224 178 19 . . . en-wikipedia-org-9224 179 1 For for IN en-wikipedia-org-9224 179 2 example example NN en-wikipedia-org-9224 179 3 , , , en-wikipedia-org-9224 179 4 female female JJ en-wikipedia-org-9224 179 5 sex sex NN en-wikipedia-org-9224 179 6 hormones hormone NNS en-wikipedia-org-9224 179 7 are be VBP en-wikipedia-org-9224 179 8 known know VBN en-wikipedia-org-9224 179 9 immunostimulators immunostimulator NNS en-wikipedia-org-9224 179 10 of of IN en-wikipedia-org-9224 179 11 both both DT en-wikipedia-org-9224 179 12 adaptive[85 adaptive[85 NNP en-wikipedia-org-9224 179 13 ] ] -RRB- en-wikipedia-org-9224 179 14 and and CC en-wikipedia-org-9224 179 15 innate innate VB en-wikipedia-org-9224 179 16 immune immune JJ en-wikipedia-org-9224 179 17 responses response NNS en-wikipedia-org-9224 179 18 . . . en-wikipedia-org-9224 180 1 [ [ -LRB- en-wikipedia-org-9224 180 2 86 86 CD en-wikipedia-org-9224 180 3 ] ] -RRB- en-wikipedia-org-9224 180 4 Some some DT en-wikipedia-org-9224 180 5 autoimmune autoimmune JJ en-wikipedia-org-9224 180 6 diseases disease NNS en-wikipedia-org-9224 180 7 such such JJ en-wikipedia-org-9224 180 8 as as IN en-wikipedia-org-9224 180 9 lupus lupus NNP en-wikipedia-org-9224 180 10 erythematosus erythematosus NN en-wikipedia-org-9224 180 11 strike strike NN en-wikipedia-org-9224 180 12 women woman NNS en-wikipedia-org-9224 180 13 preferentially preferentially RB en-wikipedia-org-9224 180 14 , , , en-wikipedia-org-9224 180 15 and and CC en-wikipedia-org-9224 180 16 their -PRON- PRP$ en-wikipedia-org-9224 180 17 onset onset NN en-wikipedia-org-9224 180 18 often often RB en-wikipedia-org-9224 180 19 coincides coincide VBZ en-wikipedia-org-9224 180 20 with with IN en-wikipedia-org-9224 180 21 puberty puberty NN en-wikipedia-org-9224 180 22 . . . en-wikipedia-org-9224 181 1 By by IN en-wikipedia-org-9224 181 2 contrast contrast NN en-wikipedia-org-9224 181 3 , , , en-wikipedia-org-9224 181 4 male male JJ en-wikipedia-org-9224 181 5 sex sex NN en-wikipedia-org-9224 181 6 hormones hormone NNS en-wikipedia-org-9224 181 7 such such JJ en-wikipedia-org-9224 181 8 as as IN en-wikipedia-org-9224 181 9 testosterone testosterone NN en-wikipedia-org-9224 181 10 seem seem VBP en-wikipedia-org-9224 181 11 to to TO en-wikipedia-org-9224 181 12 be be VB en-wikipedia-org-9224 181 13 immunosuppressive immunosuppressive JJ en-wikipedia-org-9224 181 14 . . . en-wikipedia-org-9224 182 1 [ [ -LRB- en-wikipedia-org-9224 182 2 87 87 CD en-wikipedia-org-9224 182 3 ] ] -RRB- en-wikipedia-org-9224 182 4 Other other JJ en-wikipedia-org-9224 182 5 hormones hormone NNS en-wikipedia-org-9224 182 6 appear appear VBP en-wikipedia-org-9224 182 7 to to TO en-wikipedia-org-9224 182 8 regulate regulate VB en-wikipedia-org-9224 182 9 the the DT en-wikipedia-org-9224 182 10 immune immune JJ en-wikipedia-org-9224 182 11 system system NN en-wikipedia-org-9224 182 12 as as RB en-wikipedia-org-9224 182 13 well well RB en-wikipedia-org-9224 182 14 , , , en-wikipedia-org-9224 182 15 most most RBS en-wikipedia-org-9224 182 16 notably notably RB en-wikipedia-org-9224 182 17 prolactin prolactin NN en-wikipedia-org-9224 182 18 , , , en-wikipedia-org-9224 182 19 growth growth NN en-wikipedia-org-9224 182 20 hormone hormone NN en-wikipedia-org-9224 182 21 and and CC en-wikipedia-org-9224 182 22 vitamin vitamin NN en-wikipedia-org-9224 182 23 D.[88][89 D.[88][89 NNS en-wikipedia-org-9224 182 24 ] ] -RRB- en-wikipedia-org-9224 182 25 Vitamin vitamin NN en-wikipedia-org-9224 182 26 D[edit d[edit NN en-wikipedia-org-9224 182 27 ] ] -RRB- en-wikipedia-org-9224 182 28 When when WRB en-wikipedia-org-9224 182 29 a a DT en-wikipedia-org-9224 182 30 T t NN en-wikipedia-org-9224 182 31 - - HYPH en-wikipedia-org-9224 182 32 cell cell NN en-wikipedia-org-9224 182 33 encounters encounter VBZ en-wikipedia-org-9224 182 34 a a DT en-wikipedia-org-9224 182 35 foreign foreign JJ en-wikipedia-org-9224 182 36 pathogen pathogen NN en-wikipedia-org-9224 182 37 , , , en-wikipedia-org-9224 182 38 it -PRON- PRP en-wikipedia-org-9224 182 39 extends extend VBZ en-wikipedia-org-9224 182 40 a a DT en-wikipedia-org-9224 182 41 vitamin vitamin NN en-wikipedia-org-9224 182 42 D d JJ en-wikipedia-org-9224 182 43 receptor receptor NN en-wikipedia-org-9224 182 44 . . . en-wikipedia-org-9224 183 1 This this DT en-wikipedia-org-9224 183 2 is be VBZ en-wikipedia-org-9224 183 3 essentially essentially RB en-wikipedia-org-9224 183 4 a a DT en-wikipedia-org-9224 183 5 signaling signal VBG en-wikipedia-org-9224 183 6 device device NN en-wikipedia-org-9224 183 7 that that WDT en-wikipedia-org-9224 183 8 allows allow VBZ en-wikipedia-org-9224 183 9 the the DT en-wikipedia-org-9224 183 10 T t NN en-wikipedia-org-9224 183 11 - - HYPH en-wikipedia-org-9224 183 12 cell cell NN en-wikipedia-org-9224 183 13 to to TO en-wikipedia-org-9224 183 14 bind bind VB en-wikipedia-org-9224 183 15 to to IN en-wikipedia-org-9224 183 16 the the DT en-wikipedia-org-9224 183 17 active active JJ en-wikipedia-org-9224 183 18 form form NN en-wikipedia-org-9224 183 19 of of IN en-wikipedia-org-9224 183 20 vitamin vitamin NN en-wikipedia-org-9224 183 21 D d NN en-wikipedia-org-9224 183 22 , , , en-wikipedia-org-9224 183 23 the the DT en-wikipedia-org-9224 183 24 steroid steroid NN en-wikipedia-org-9224 183 25 hormone hormone NNP en-wikipedia-org-9224 183 26 calcitriol calcitriol NNP en-wikipedia-org-9224 183 27 . . . en-wikipedia-org-9224 184 1 T T NNP en-wikipedia-org-9224 184 2 - - HYPH en-wikipedia-org-9224 184 3 cells cell NNS en-wikipedia-org-9224 184 4 have have VBP en-wikipedia-org-9224 184 5 a a DT en-wikipedia-org-9224 184 6 symbiotic symbiotic JJ en-wikipedia-org-9224 184 7 relationship relationship NN en-wikipedia-org-9224 184 8 with with IN en-wikipedia-org-9224 184 9 vitamin vitamin NN en-wikipedia-org-9224 184 10 D. D. NNP en-wikipedia-org-9224 184 11 Not not RB en-wikipedia-org-9224 184 12 only only RB en-wikipedia-org-9224 184 13 does do VBZ en-wikipedia-org-9224 184 14 the the DT en-wikipedia-org-9224 184 15 T t NN en-wikipedia-org-9224 184 16 - - HYPH en-wikipedia-org-9224 184 17 cell cell NN en-wikipedia-org-9224 184 18 extend extend VBP en-wikipedia-org-9224 184 19 a a DT en-wikipedia-org-9224 184 20 vitamin vitamin NN en-wikipedia-org-9224 184 21 D d JJ en-wikipedia-org-9224 184 22 receptor receptor NN en-wikipedia-org-9224 184 23 , , , en-wikipedia-org-9224 184 24 in in IN en-wikipedia-org-9224 184 25 essence essence NN en-wikipedia-org-9224 184 26 asking ask VBG en-wikipedia-org-9224 184 27 to to TO en-wikipedia-org-9224 184 28 bind bind VB en-wikipedia-org-9224 184 29 to to IN en-wikipedia-org-9224 184 30 the the DT en-wikipedia-org-9224 184 31 steroid steroid NNP en-wikipedia-org-9224 184 32 hormone hormone NNP en-wikipedia-org-9224 184 33 version version NN en-wikipedia-org-9224 184 34 of of IN en-wikipedia-org-9224 184 35 vitamin vitamin NN en-wikipedia-org-9224 184 36 D d NN en-wikipedia-org-9224 184 37 , , , en-wikipedia-org-9224 184 38 calcitriol calcitriol NN en-wikipedia-org-9224 184 39 , , , en-wikipedia-org-9224 184 40 but but CC en-wikipedia-org-9224 184 41 the the DT en-wikipedia-org-9224 184 42 T t NN en-wikipedia-org-9224 184 43 - - HYPH en-wikipedia-org-9224 184 44 cell cell NN en-wikipedia-org-9224 184 45 expresses express VBZ en-wikipedia-org-9224 184 46 the the DT en-wikipedia-org-9224 184 47 gene gene NN en-wikipedia-org-9224 184 48 CYP27B1 CYP27B1 NNP en-wikipedia-org-9224 184 49 , , , en-wikipedia-org-9224 184 50 which which WDT en-wikipedia-org-9224 184 51 is be VBZ en-wikipedia-org-9224 184 52 the the DT en-wikipedia-org-9224 184 53 gene gene NN en-wikipedia-org-9224 184 54 responsible responsible JJ en-wikipedia-org-9224 184 55 for for IN en-wikipedia-org-9224 184 56 converting convert VBG en-wikipedia-org-9224 184 57 the the DT en-wikipedia-org-9224 184 58 pre pre JJ en-wikipedia-org-9224 184 59 - - JJ en-wikipedia-org-9224 184 60 hormone hormone JJ en-wikipedia-org-9224 184 61 version version NN en-wikipedia-org-9224 184 62 of of IN en-wikipedia-org-9224 184 63 vitamin vitamin NN en-wikipedia-org-9224 184 64 D d NN en-wikipedia-org-9224 184 65 , , , en-wikipedia-org-9224 184 66 calcidiol calcidiol NN en-wikipedia-org-9224 184 67 into into IN en-wikipedia-org-9224 184 68 calcitriol calcitriol NNP en-wikipedia-org-9224 184 69 . . . en-wikipedia-org-9224 185 1 Only only RB en-wikipedia-org-9224 185 2 after after IN en-wikipedia-org-9224 185 3 binding bind VBG en-wikipedia-org-9224 185 4 to to IN en-wikipedia-org-9224 185 5 calcitriol calcitriol NN en-wikipedia-org-9224 185 6 can can MD en-wikipedia-org-9224 185 7 T t NN en-wikipedia-org-9224 185 8 - - HYPH en-wikipedia-org-9224 185 9 cells cell NNS en-wikipedia-org-9224 185 10 perform perform VBP en-wikipedia-org-9224 185 11 their -PRON- PRP$ en-wikipedia-org-9224 185 12 intended intend VBN en-wikipedia-org-9224 185 13 function function NN en-wikipedia-org-9224 185 14 . . . en-wikipedia-org-9224 186 1 Other other JJ en-wikipedia-org-9224 186 2 immune immune JJ en-wikipedia-org-9224 186 3 system system NN en-wikipedia-org-9224 186 4 cells cell NNS en-wikipedia-org-9224 186 5 that that WDT en-wikipedia-org-9224 186 6 are be VBP en-wikipedia-org-9224 186 7 known know VBN en-wikipedia-org-9224 186 8 to to TO en-wikipedia-org-9224 186 9 express express VB en-wikipedia-org-9224 186 10 CYP27B1 CYP27B1 NNP en-wikipedia-org-9224 186 11 and and CC en-wikipedia-org-9224 186 12 thus thus RB en-wikipedia-org-9224 186 13 activate activate VB en-wikipedia-org-9224 186 14 vitamin vitamin NN en-wikipedia-org-9224 186 15 D D NNP en-wikipedia-org-9224 186 16 calcidiol calcidiol NN en-wikipedia-org-9224 186 17 , , , en-wikipedia-org-9224 186 18 are be VBP en-wikipedia-org-9224 186 19 dendritic dendritic JJ en-wikipedia-org-9224 186 20 cells cell NNS en-wikipedia-org-9224 186 21 , , , en-wikipedia-org-9224 186 22 keratinocytes keratinocyte NNS en-wikipedia-org-9224 186 23 and and CC en-wikipedia-org-9224 186 24 macrophages macrophage NNS en-wikipedia-org-9224 186 25 . . . en-wikipedia-org-9224 187 1 [ [ -LRB- en-wikipedia-org-9224 187 2 90][91 90][91 CD en-wikipedia-org-9224 187 3 ] ] -RRB- en-wikipedia-org-9224 187 4 Sleep sleep NN en-wikipedia-org-9224 187 5 and and CC en-wikipedia-org-9224 187 6 rest[edit rest[edit LS en-wikipedia-org-9224 187 7 ] ] -RRB- en-wikipedia-org-9224 187 8 The the DT en-wikipedia-org-9224 187 9 immune immune JJ en-wikipedia-org-9224 187 10 system system NN en-wikipedia-org-9224 187 11 is be VBZ en-wikipedia-org-9224 187 12 affected affect VBN en-wikipedia-org-9224 187 13 by by IN en-wikipedia-org-9224 187 14 sleep sleep NN en-wikipedia-org-9224 187 15 and and CC en-wikipedia-org-9224 187 16 rest rest NN en-wikipedia-org-9224 187 17 , , , en-wikipedia-org-9224 187 18 and and CC en-wikipedia-org-9224 187 19 sleep sleep NN en-wikipedia-org-9224 187 20 deprivation deprivation NN en-wikipedia-org-9224 187 21 is be VBZ en-wikipedia-org-9224 187 22 detrimental detrimental JJ en-wikipedia-org-9224 187 23 to to IN en-wikipedia-org-9224 187 24 immune immune JJ en-wikipedia-org-9224 187 25 function function NN en-wikipedia-org-9224 187 26 . . . en-wikipedia-org-9224 188 1 [ [ -LRB- en-wikipedia-org-9224 188 2 92 92 CD en-wikipedia-org-9224 188 3 ] ] -RRB- en-wikipedia-org-9224 188 4 Complex complex JJ en-wikipedia-org-9224 188 5 feedback feedback NN en-wikipedia-org-9224 188 6 loops loop NNS en-wikipedia-org-9224 188 7 involving involve VBG en-wikipedia-org-9224 188 8 cytokines cytokine NNS en-wikipedia-org-9224 188 9 , , , en-wikipedia-org-9224 188 10 such such JJ en-wikipedia-org-9224 188 11 as as IN en-wikipedia-org-9224 188 12 interleukin-1 interleukin-1 NNP en-wikipedia-org-9224 188 13 and and CC en-wikipedia-org-9224 188 14 tumor tumor NN en-wikipedia-org-9224 188 15 necrosis necrosis NN en-wikipedia-org-9224 188 16 factor factor NN en-wikipedia-org-9224 188 17 - - HYPH en-wikipedia-org-9224 188 18 α α NNP en-wikipedia-org-9224 188 19 produced produce VBN en-wikipedia-org-9224 188 20 in in IN en-wikipedia-org-9224 188 21 response response NN en-wikipedia-org-9224 188 22 to to IN en-wikipedia-org-9224 188 23 infection infection NN en-wikipedia-org-9224 188 24 , , , en-wikipedia-org-9224 188 25 appear appear VB en-wikipedia-org-9224 188 26 to to TO en-wikipedia-org-9224 188 27 also also RB en-wikipedia-org-9224 188 28 play play VB en-wikipedia-org-9224 188 29 a a DT en-wikipedia-org-9224 188 30 role role NN en-wikipedia-org-9224 188 31 in in IN en-wikipedia-org-9224 188 32 the the DT en-wikipedia-org-9224 188 33 regulation regulation NN en-wikipedia-org-9224 188 34 of of IN en-wikipedia-org-9224 188 35 non non JJ en-wikipedia-org-9224 188 36 - - JJ en-wikipedia-org-9224 188 37 rapid rapid JJ en-wikipedia-org-9224 188 38 eye eye NN en-wikipedia-org-9224 188 39 movement movement NN en-wikipedia-org-9224 188 40 ( ( -LRB- en-wikipedia-org-9224 188 41 REM REM NNP en-wikipedia-org-9224 188 42 ) ) -RRB- en-wikipedia-org-9224 188 43 sleep sleep NN en-wikipedia-org-9224 188 44 . . . en-wikipedia-org-9224 189 1 [ [ -LRB- en-wikipedia-org-9224 189 2 93 93 CD en-wikipedia-org-9224 189 3 ] ] -RRB- en-wikipedia-org-9224 189 4 Thus thus RB en-wikipedia-org-9224 189 5 the the DT en-wikipedia-org-9224 189 6 immune immune JJ en-wikipedia-org-9224 189 7 response response NN en-wikipedia-org-9224 189 8 to to IN en-wikipedia-org-9224 189 9 infection infection NN en-wikipedia-org-9224 189 10 may may MD en-wikipedia-org-9224 189 11 result result VB en-wikipedia-org-9224 189 12 in in IN en-wikipedia-org-9224 189 13 changes change NNS en-wikipedia-org-9224 189 14 to to IN en-wikipedia-org-9224 189 15 the the DT en-wikipedia-org-9224 189 16 sleep sleep NN en-wikipedia-org-9224 189 17 cycle cycle NN en-wikipedia-org-9224 189 18 , , , en-wikipedia-org-9224 189 19 including include VBG en-wikipedia-org-9224 189 20 an an DT en-wikipedia-org-9224 189 21 increase increase NN en-wikipedia-org-9224 189 22 in in IN en-wikipedia-org-9224 189 23 slow slow JJ en-wikipedia-org-9224 189 24 - - HYPH en-wikipedia-org-9224 189 25 wave wave NN en-wikipedia-org-9224 189 26 sleep sleep NN en-wikipedia-org-9224 189 27 relative relative JJ en-wikipedia-org-9224 189 28 to to IN en-wikipedia-org-9224 189 29 REM rem NN en-wikipedia-org-9224 189 30 sleep sleep NN en-wikipedia-org-9224 189 31 . . . en-wikipedia-org-9224 190 1 [ [ -LRB- en-wikipedia-org-9224 190 2 94 94 CD en-wikipedia-org-9224 190 3 ] ] -RRB- en-wikipedia-org-9224 190 4 In in IN en-wikipedia-org-9224 190 5 people people NNS en-wikipedia-org-9224 190 6 suffering suffer VBG en-wikipedia-org-9224 190 7 from from IN en-wikipedia-org-9224 190 8 sleep sleep NN en-wikipedia-org-9224 190 9 deprivation deprivation NN en-wikipedia-org-9224 190 10 , , , en-wikipedia-org-9224 190 11 active active JJ en-wikipedia-org-9224 190 12 immunizations immunization NNS en-wikipedia-org-9224 190 13 may may MD en-wikipedia-org-9224 190 14 have have VB en-wikipedia-org-9224 190 15 a a DT en-wikipedia-org-9224 190 16 diminished diminished JJ en-wikipedia-org-9224 190 17 effect effect NN en-wikipedia-org-9224 190 18 and and CC en-wikipedia-org-9224 190 19 may may MD en-wikipedia-org-9224 190 20 result result VB en-wikipedia-org-9224 190 21 in in IN en-wikipedia-org-9224 190 22 lower low JJR en-wikipedia-org-9224 190 23 antibody antibody NN en-wikipedia-org-9224 190 24 production production NN en-wikipedia-org-9224 190 25 , , , en-wikipedia-org-9224 190 26 and and CC en-wikipedia-org-9224 190 27 a a DT en-wikipedia-org-9224 190 28 lower low JJR en-wikipedia-org-9224 190 29 immune immune JJ en-wikipedia-org-9224 190 30 response response NN en-wikipedia-org-9224 190 31 , , , en-wikipedia-org-9224 190 32 than than IN en-wikipedia-org-9224 190 33 would would MD en-wikipedia-org-9224 190 34 be be VB en-wikipedia-org-9224 190 35 noted note VBN en-wikipedia-org-9224 190 36 in in IN en-wikipedia-org-9224 190 37 a a DT en-wikipedia-org-9224 190 38 well well RB en-wikipedia-org-9224 190 39 - - HYPH en-wikipedia-org-9224 190 40 rested rest VBN en-wikipedia-org-9224 190 41 individual individual NN en-wikipedia-org-9224 190 42 . . . en-wikipedia-org-9224 191 1 [ [ -LRB- en-wikipedia-org-9224 191 2 95 95 CD en-wikipedia-org-9224 191 3 ] ] -RRB- en-wikipedia-org-9224 191 4 Additionally additionally RB en-wikipedia-org-9224 191 5 , , , en-wikipedia-org-9224 191 6 proteins protein NNS en-wikipedia-org-9224 191 7 such such JJ en-wikipedia-org-9224 191 8 as as IN en-wikipedia-org-9224 191 9 NFIL3 NFIL3 NNP en-wikipedia-org-9224 191 10 , , , en-wikipedia-org-9224 191 11 which which WDT en-wikipedia-org-9224 191 12 have have VBP en-wikipedia-org-9224 191 13 been be VBN en-wikipedia-org-9224 191 14 shown show VBN en-wikipedia-org-9224 191 15 to to TO en-wikipedia-org-9224 191 16 be be VB en-wikipedia-org-9224 191 17 closely closely RB en-wikipedia-org-9224 191 18 intertwined intertwine VBN en-wikipedia-org-9224 191 19 with with IN en-wikipedia-org-9224 191 20 both both DT en-wikipedia-org-9224 191 21 T T NNP en-wikipedia-org-9224 191 22 - - HYPH en-wikipedia-org-9224 191 23 cell cell NN en-wikipedia-org-9224 191 24 differentiation differentiation NN en-wikipedia-org-9224 191 25 and and CC en-wikipedia-org-9224 191 26 our -PRON- PRP$ en-wikipedia-org-9224 191 27 circadian circadian JJ en-wikipedia-org-9224 191 28 rhythms rhythm NNS en-wikipedia-org-9224 191 29 , , , en-wikipedia-org-9224 191 30 can can MD en-wikipedia-org-9224 191 31 be be VB en-wikipedia-org-9224 191 32 affected affect VBN en-wikipedia-org-9224 191 33 through through IN en-wikipedia-org-9224 191 34 the the DT en-wikipedia-org-9224 191 35 disturbance disturbance NN en-wikipedia-org-9224 191 36 of of IN en-wikipedia-org-9224 191 37 natural natural JJ en-wikipedia-org-9224 191 38 light light JJ en-wikipedia-org-9224 191 39 and and CC en-wikipedia-org-9224 191 40 dark dark JJ en-wikipedia-org-9224 191 41 cycles cycle NNS en-wikipedia-org-9224 191 42 through through IN en-wikipedia-org-9224 191 43 instances instance NNS en-wikipedia-org-9224 191 44 of of IN en-wikipedia-org-9224 191 45 sleep sleep NN en-wikipedia-org-9224 191 46 deprivation deprivation NN en-wikipedia-org-9224 191 47 , , , en-wikipedia-org-9224 191 48 shift shift NN en-wikipedia-org-9224 191 49 work work NN en-wikipedia-org-9224 191 50 . . . en-wikipedia-org-9224 192 1 As as IN en-wikipedia-org-9224 192 2 a a DT en-wikipedia-org-9224 192 3 result result NN en-wikipedia-org-9224 192 4 , , , en-wikipedia-org-9224 192 5 these these DT en-wikipedia-org-9224 192 6 disruptions disruption NNS en-wikipedia-org-9224 192 7 can can MD en-wikipedia-org-9224 192 8 lead lead VB en-wikipedia-org-9224 192 9 to to IN en-wikipedia-org-9224 192 10 an an DT en-wikipedia-org-9224 192 11 increase increase NN en-wikipedia-org-9224 192 12 in in IN en-wikipedia-org-9224 192 13 chronic chronic JJ en-wikipedia-org-9224 192 14 conditions condition NNS en-wikipedia-org-9224 192 15 such such JJ en-wikipedia-org-9224 192 16 as as IN en-wikipedia-org-9224 192 17 heart heart NN en-wikipedia-org-9224 192 18 disease disease NN en-wikipedia-org-9224 192 19 , , , en-wikipedia-org-9224 192 20 chronic chronic JJ en-wikipedia-org-9224 192 21 pain pain NN en-wikipedia-org-9224 192 22 , , , en-wikipedia-org-9224 192 23 and and CC en-wikipedia-org-9224 192 24 asthma asthma NN en-wikipedia-org-9224 192 25 . . . en-wikipedia-org-9224 193 1 [ [ -LRB- en-wikipedia-org-9224 193 2 96 96 CD en-wikipedia-org-9224 193 3 ] ] -RRB- en-wikipedia-org-9224 193 4 In in IN en-wikipedia-org-9224 193 5 addition addition NN en-wikipedia-org-9224 193 6 to to IN en-wikipedia-org-9224 193 7 the the DT en-wikipedia-org-9224 193 8 negative negative JJ en-wikipedia-org-9224 193 9 consequences consequence NNS en-wikipedia-org-9224 193 10 of of IN en-wikipedia-org-9224 193 11 sleep sleep NN en-wikipedia-org-9224 193 12 deprivation deprivation NN en-wikipedia-org-9224 193 13 , , , en-wikipedia-org-9224 193 14 sleep sleep NN en-wikipedia-org-9224 193 15 and and CC en-wikipedia-org-9224 193 16 the the DT en-wikipedia-org-9224 193 17 intertwined intertwine VBN en-wikipedia-org-9224 193 18 circadian circadian JJ en-wikipedia-org-9224 193 19 system system NN en-wikipedia-org-9224 193 20 have have VBP en-wikipedia-org-9224 193 21 been be VBN en-wikipedia-org-9224 193 22 shown show VBN en-wikipedia-org-9224 193 23 to to TO en-wikipedia-org-9224 193 24 have have VB en-wikipedia-org-9224 193 25 strong strong JJ en-wikipedia-org-9224 193 26 regulatory regulatory JJ en-wikipedia-org-9224 193 27 effects effect NNS en-wikipedia-org-9224 193 28 on on IN en-wikipedia-org-9224 193 29 immunological immunological JJ en-wikipedia-org-9224 193 30 functions function NNS en-wikipedia-org-9224 193 31 affecting affect VBG en-wikipedia-org-9224 193 32 both both DT en-wikipedia-org-9224 193 33 innate innate VBP en-wikipedia-org-9224 193 34 and and CC en-wikipedia-org-9224 193 35 adaptive adaptive JJ en-wikipedia-org-9224 193 36 immunity immunity NN en-wikipedia-org-9224 193 37 . . . en-wikipedia-org-9224 194 1 First first RB en-wikipedia-org-9224 194 2 , , , en-wikipedia-org-9224 194 3 during during IN en-wikipedia-org-9224 194 4 the the DT en-wikipedia-org-9224 194 5 early early JJ en-wikipedia-org-9224 194 6 slow slow JJ en-wikipedia-org-9224 194 7 - - HYPH en-wikipedia-org-9224 194 8 wave wave NN en-wikipedia-org-9224 194 9 - - HYPH en-wikipedia-org-9224 194 10 sleep sleep NN en-wikipedia-org-9224 194 11 stage stage NN en-wikipedia-org-9224 194 12 , , , en-wikipedia-org-9224 194 13 a a DT en-wikipedia-org-9224 194 14 sudden sudden JJ en-wikipedia-org-9224 194 15 drop drop NN en-wikipedia-org-9224 194 16 in in IN en-wikipedia-org-9224 194 17 blood blood NN en-wikipedia-org-9224 194 18 levels level NNS en-wikipedia-org-9224 194 19 of of IN en-wikipedia-org-9224 194 20 cortisol cortisol NNP en-wikipedia-org-9224 194 21 , , , en-wikipedia-org-9224 194 22 epinephrine epinephrine NNP en-wikipedia-org-9224 194 23 , , , en-wikipedia-org-9224 194 24 and and CC en-wikipedia-org-9224 194 25 norepinephrine norepinephrine NN en-wikipedia-org-9224 194 26 causes cause VBZ en-wikipedia-org-9224 194 27 increased increase VBN en-wikipedia-org-9224 194 28 blood blood NN en-wikipedia-org-9224 194 29 levels level NNS en-wikipedia-org-9224 194 30 of of IN en-wikipedia-org-9224 194 31 the the DT en-wikipedia-org-9224 194 32 hormones hormones NNPS en-wikipedia-org-9224 194 33 leptin leptin NNP en-wikipedia-org-9224 194 34 , , , en-wikipedia-org-9224 194 35 pituitary pituitary JJ en-wikipedia-org-9224 194 36 growth growth NN en-wikipedia-org-9224 194 37 hormone hormone NN en-wikipedia-org-9224 194 38 , , , en-wikipedia-org-9224 194 39 and and CC en-wikipedia-org-9224 194 40 prolactin prolactin NN en-wikipedia-org-9224 194 41 . . . en-wikipedia-org-9224 195 1 These these DT en-wikipedia-org-9224 195 2 signals signal NNS en-wikipedia-org-9224 195 3 induce induce VBP en-wikipedia-org-9224 195 4 a a DT en-wikipedia-org-9224 195 5 pro pro JJ en-wikipedia-org-9224 195 6 - - JJ en-wikipedia-org-9224 195 7 inflammatory inflammatory JJ en-wikipedia-org-9224 195 8 state state NN en-wikipedia-org-9224 195 9 through through IN en-wikipedia-org-9224 195 10 the the DT en-wikipedia-org-9224 195 11 production production NN en-wikipedia-org-9224 195 12 of of IN en-wikipedia-org-9224 195 13 the the DT en-wikipedia-org-9224 195 14 pro pro JJ en-wikipedia-org-9224 195 15 - - JJ en-wikipedia-org-9224 195 16 inflammatory inflammatory JJ en-wikipedia-org-9224 195 17 cytokines cytokine NNS en-wikipedia-org-9224 195 18 interleukin-1 interleukin-1 NNP en-wikipedia-org-9224 195 19 , , , en-wikipedia-org-9224 195 20 interleukin-12 interleukin-12 NN en-wikipedia-org-9224 195 21 , , , en-wikipedia-org-9224 195 22 TNF TNF NNP en-wikipedia-org-9224 195 23 - - HYPH en-wikipedia-org-9224 195 24 alpha alpha NN en-wikipedia-org-9224 195 25 and and CC en-wikipedia-org-9224 195 26 IFN IFN NNP en-wikipedia-org-9224 195 27 - - HYPH en-wikipedia-org-9224 195 28 gamma gamma NNP en-wikipedia-org-9224 195 29 . . . en-wikipedia-org-9224 196 1 These these DT en-wikipedia-org-9224 196 2 cytokines cytokine NNS en-wikipedia-org-9224 196 3 then then RB en-wikipedia-org-9224 196 4 stimulate stimulate VBP en-wikipedia-org-9224 196 5 immune immune JJ en-wikipedia-org-9224 196 6 functions function NNS en-wikipedia-org-9224 196 7 such such JJ en-wikipedia-org-9224 196 8 as as IN en-wikipedia-org-9224 196 9 immune immune JJ en-wikipedia-org-9224 196 10 cell cell NN en-wikipedia-org-9224 196 11 activation activation NN en-wikipedia-org-9224 196 12 , , , en-wikipedia-org-9224 196 13 proliferation proliferation NN en-wikipedia-org-9224 196 14 , , , en-wikipedia-org-9224 196 15 and and CC en-wikipedia-org-9224 196 16 differentiation differentiation NN en-wikipedia-org-9224 196 17 . . . en-wikipedia-org-9224 197 1 It -PRON- PRP en-wikipedia-org-9224 197 2 is be VBZ en-wikipedia-org-9224 197 3 during during IN en-wikipedia-org-9224 197 4 this this DT en-wikipedia-org-9224 197 5 time time NN en-wikipedia-org-9224 197 6 that that WDT en-wikipedia-org-9224 197 7 undifferentiated undifferentiate VBD en-wikipedia-org-9224 197 8 , , , en-wikipedia-org-9224 197 9 or or CC en-wikipedia-org-9224 197 10 less less RBR en-wikipedia-org-9224 197 11 differentiated differentiated JJ en-wikipedia-org-9224 197 12 , , , en-wikipedia-org-9224 197 13 like like IN en-wikipedia-org-9224 197 14 naïve naïve JJ en-wikipedia-org-9224 197 15 and and CC en-wikipedia-org-9224 197 16 central central JJ en-wikipedia-org-9224 197 17 memory memory NN en-wikipedia-org-9224 197 18 T T NNP en-wikipedia-org-9224 197 19 cells cell NNS en-wikipedia-org-9224 197 20 , , , en-wikipedia-org-9224 197 21 peak peak NN en-wikipedia-org-9224 197 22 ( ( -LRB- en-wikipedia-org-9224 197 23 that that RB en-wikipedia-org-9224 197 24 is is RB en-wikipedia-org-9224 197 25 , , , en-wikipedia-org-9224 197 26 during during IN en-wikipedia-org-9224 197 27 a a DT en-wikipedia-org-9224 197 28 time time NN en-wikipedia-org-9224 197 29 of of IN en-wikipedia-org-9224 197 30 a a DT en-wikipedia-org-9224 197 31 slowly slowly RB en-wikipedia-org-9224 197 32 evolving evolve VBG en-wikipedia-org-9224 197 33 adaptive adaptive JJ en-wikipedia-org-9224 197 34 immune immune JJ en-wikipedia-org-9224 197 35 response response NN en-wikipedia-org-9224 197 36 ) ) -RRB- en-wikipedia-org-9224 197 37 . . . en-wikipedia-org-9224 198 1 In in IN en-wikipedia-org-9224 198 2 addition addition NN en-wikipedia-org-9224 198 3 to to IN en-wikipedia-org-9224 198 4 these these DT en-wikipedia-org-9224 198 5 effects effect NNS en-wikipedia-org-9224 198 6 , , , en-wikipedia-org-9224 198 7 the the DT en-wikipedia-org-9224 198 8 milieu milieu NN en-wikipedia-org-9224 198 9 of of IN en-wikipedia-org-9224 198 10 hormones hormone NNS en-wikipedia-org-9224 198 11 produced produce VBN en-wikipedia-org-9224 198 12 at at IN en-wikipedia-org-9224 198 13 this this DT en-wikipedia-org-9224 198 14 time time NN en-wikipedia-org-9224 198 15 ( ( -LRB- en-wikipedia-org-9224 198 16 leptin leptin NNP en-wikipedia-org-9224 198 17 , , , en-wikipedia-org-9224 198 18 pituitary pituitary JJ en-wikipedia-org-9224 198 19 growth growth NN en-wikipedia-org-9224 198 20 hormone hormone NN en-wikipedia-org-9224 198 21 , , , en-wikipedia-org-9224 198 22 and and CC en-wikipedia-org-9224 198 23 prolactin prolactin NN en-wikipedia-org-9224 198 24 ) ) -RRB- en-wikipedia-org-9224 198 25 supports support VBZ en-wikipedia-org-9224 198 26 the the DT en-wikipedia-org-9224 198 27 interactions interaction NNS en-wikipedia-org-9224 198 28 between between IN en-wikipedia-org-9224 198 29 APCs APCs NNPS en-wikipedia-org-9224 198 30 and and CC en-wikipedia-org-9224 198 31 T t NN en-wikipedia-org-9224 198 32 - - HYPH en-wikipedia-org-9224 198 33 cells cell NNS en-wikipedia-org-9224 198 34 , , , en-wikipedia-org-9224 198 35 a a DT en-wikipedia-org-9224 198 36 shift shift NN en-wikipedia-org-9224 198 37 of of IN en-wikipedia-org-9224 198 38 the the DT en-wikipedia-org-9224 198 39 Th1 th1 NN en-wikipedia-org-9224 198 40 / / SYM en-wikipedia-org-9224 198 41 Th2 th2 NN en-wikipedia-org-9224 198 42 cytokine cytokine JJ en-wikipedia-org-9224 198 43 balance balance NN en-wikipedia-org-9224 198 44 towards towards IN en-wikipedia-org-9224 198 45 one one CD en-wikipedia-org-9224 198 46 that that WDT en-wikipedia-org-9224 198 47 supports support VBZ en-wikipedia-org-9224 198 48 Th1 th1 NN en-wikipedia-org-9224 198 49 , , , en-wikipedia-org-9224 198 50 an an DT en-wikipedia-org-9224 198 51 increase increase NN en-wikipedia-org-9224 198 52 in in IN en-wikipedia-org-9224 198 53 overall overall JJ en-wikipedia-org-9224 198 54 Th Th NNP en-wikipedia-org-9224 198 55 cell cell NN en-wikipedia-org-9224 198 56 proliferation proliferation NN en-wikipedia-org-9224 198 57 , , , en-wikipedia-org-9224 198 58 and and CC en-wikipedia-org-9224 198 59 naïve naïve NNP en-wikipedia-org-9224 198 60 T T NNP en-wikipedia-org-9224 198 61 cell cell NN en-wikipedia-org-9224 198 62 migration migration NN en-wikipedia-org-9224 198 63 to to TO en-wikipedia-org-9224 198 64 lymph lymph VB en-wikipedia-org-9224 198 65 nodes node NNS en-wikipedia-org-9224 198 66 . . . en-wikipedia-org-9224 199 1 This this DT en-wikipedia-org-9224 199 2 is be VBZ en-wikipedia-org-9224 199 3 also also RB en-wikipedia-org-9224 199 4 thought think VBN en-wikipedia-org-9224 199 5 to to TO en-wikipedia-org-9224 199 6 support support VB en-wikipedia-org-9224 199 7 the the DT en-wikipedia-org-9224 199 8 formation formation NN en-wikipedia-org-9224 199 9 of of IN en-wikipedia-org-9224 199 10 long long RB en-wikipedia-org-9224 199 11 - - HYPH en-wikipedia-org-9224 199 12 lasting last VBG en-wikipedia-org-9224 199 13 immune immune JJ en-wikipedia-org-9224 199 14 memory memory NN en-wikipedia-org-9224 199 15 through through IN en-wikipedia-org-9224 199 16 the the DT en-wikipedia-org-9224 199 17 initiation initiation NN en-wikipedia-org-9224 199 18 of of IN en-wikipedia-org-9224 199 19 Th1 th1 CD en-wikipedia-org-9224 199 20 immune immune JJ en-wikipedia-org-9224 199 21 responses response NNS en-wikipedia-org-9224 199 22 . . . en-wikipedia-org-9224 200 1 [ [ -LRB- en-wikipedia-org-9224 200 2 97 97 CD en-wikipedia-org-9224 200 3 ] ] -RRB- en-wikipedia-org-9224 200 4 During during IN en-wikipedia-org-9224 200 5 wake wake NN en-wikipedia-org-9224 200 6 periods period NNS en-wikipedia-org-9224 200 7 differentiated differentiate VBN en-wikipedia-org-9224 200 8 effector effector NN en-wikipedia-org-9224 200 9 cells cell NNS en-wikipedia-org-9224 200 10 , , , en-wikipedia-org-9224 200 11 such such JJ en-wikipedia-org-9224 200 12 as as IN en-wikipedia-org-9224 200 13 cytotoxic cytotoxic NNP en-wikipedia-org-9224 200 14 natural natural JJ en-wikipedia-org-9224 200 15 killer killer NN en-wikipedia-org-9224 200 16 cells cell NNS en-wikipedia-org-9224 200 17 and and CC en-wikipedia-org-9224 200 18 cytotoxic cytotoxic JJ en-wikipedia-org-9224 200 19 T t NN en-wikipedia-org-9224 200 20 lymphocytes lymphocyte NNS en-wikipedia-org-9224 200 21 , , , en-wikipedia-org-9224 200 22 peak peak VBP en-wikipedia-org-9224 200 23 to to TO en-wikipedia-org-9224 200 24 elicit elicit VB en-wikipedia-org-9224 200 25 an an DT en-wikipedia-org-9224 200 26 effective effective JJ en-wikipedia-org-9224 200 27 response response NN en-wikipedia-org-9224 200 28 against against IN en-wikipedia-org-9224 200 29 any any DT en-wikipedia-org-9224 200 30 intruding intrude VBG en-wikipedia-org-9224 200 31 pathogens pathogen NNS en-wikipedia-org-9224 200 32 . . . en-wikipedia-org-9224 201 1 Anti anti JJ en-wikipedia-org-9224 201 2 - - JJ en-wikipedia-org-9224 201 3 inflammatory inflammatory JJ en-wikipedia-org-9224 201 4 molecules molecule NNS en-wikipedia-org-9224 201 5 , , , en-wikipedia-org-9224 201 6 such such JJ en-wikipedia-org-9224 201 7 as as IN en-wikipedia-org-9224 201 8 cortisol cortisol NNP en-wikipedia-org-9224 201 9 and and CC en-wikipedia-org-9224 201 10 catecholamines catecholamines NNP en-wikipedia-org-9224 201 11 , , , en-wikipedia-org-9224 201 12 also also RB en-wikipedia-org-9224 201 13 peak peak VBP en-wikipedia-org-9224 201 14 during during IN en-wikipedia-org-9224 201 15 awake awake JJ en-wikipedia-org-9224 201 16 active active JJ en-wikipedia-org-9224 201 17 times time NNS en-wikipedia-org-9224 201 18 . . . en-wikipedia-org-9224 202 1 Inflammation inflammation NN en-wikipedia-org-9224 202 2 would would MD en-wikipedia-org-9224 202 3 cause cause VB en-wikipedia-org-9224 202 4 serious serious JJ en-wikipedia-org-9224 202 5 cognitive cognitive JJ en-wikipedia-org-9224 202 6 and and CC en-wikipedia-org-9224 202 7 physical physical JJ en-wikipedia-org-9224 202 8 impairments impairment NNS en-wikipedia-org-9224 202 9 if if IN en-wikipedia-org-9224 202 10 it -PRON- PRP en-wikipedia-org-9224 202 11 were be VBD en-wikipedia-org-9224 202 12 to to TO en-wikipedia-org-9224 202 13 occur occur VB en-wikipedia-org-9224 202 14 during during IN en-wikipedia-org-9224 202 15 wake wake NN en-wikipedia-org-9224 202 16 times time NNS en-wikipedia-org-9224 202 17 , , , en-wikipedia-org-9224 202 18 and and CC en-wikipedia-org-9224 202 19 inflammation inflammation NN en-wikipedia-org-9224 202 20 may may MD en-wikipedia-org-9224 202 21 occur occur VB en-wikipedia-org-9224 202 22 during during IN en-wikipedia-org-9224 202 23 sleep sleep NN en-wikipedia-org-9224 202 24 times time NNS en-wikipedia-org-9224 202 25 due due JJ en-wikipedia-org-9224 202 26 to to IN en-wikipedia-org-9224 202 27 the the DT en-wikipedia-org-9224 202 28 presence presence NN en-wikipedia-org-9224 202 29 of of IN en-wikipedia-org-9224 202 30 melatonin melatonin NNP en-wikipedia-org-9224 202 31 . . . en-wikipedia-org-9224 203 1 Inflammation inflammation NN en-wikipedia-org-9224 203 2 causes cause VBZ en-wikipedia-org-9224 203 3 a a DT en-wikipedia-org-9224 203 4 great great JJ en-wikipedia-org-9224 203 5 deal deal NN en-wikipedia-org-9224 203 6 of of IN en-wikipedia-org-9224 203 7 oxidative oxidative JJ en-wikipedia-org-9224 203 8 stress stress NN en-wikipedia-org-9224 203 9 and and CC en-wikipedia-org-9224 203 10 the the DT en-wikipedia-org-9224 203 11 presence presence NN en-wikipedia-org-9224 203 12 of of IN en-wikipedia-org-9224 203 13 melatonin melatonin NNP en-wikipedia-org-9224 203 14 during during IN en-wikipedia-org-9224 203 15 sleep sleep NN en-wikipedia-org-9224 203 16 times time NNS en-wikipedia-org-9224 203 17 could could MD en-wikipedia-org-9224 203 18 actively actively RB en-wikipedia-org-9224 203 19 counteract counteract VB en-wikipedia-org-9224 203 20 free free JJ en-wikipedia-org-9224 203 21 radical radical JJ en-wikipedia-org-9224 203 22 production production NN en-wikipedia-org-9224 203 23 during during IN en-wikipedia-org-9224 203 24 this this DT en-wikipedia-org-9224 203 25 time time NN en-wikipedia-org-9224 203 26 . . . en-wikipedia-org-9224 204 1 [ [ -LRB- en-wikipedia-org-9224 204 2 97][98 97][98 CD en-wikipedia-org-9224 204 3 ] ] -RRB- en-wikipedia-org-9224 204 4 Nutrition nutrition NN en-wikipedia-org-9224 204 5 and and CC en-wikipedia-org-9224 204 6 diet[edit diet[edit LS en-wikipedia-org-9224 204 7 ] ] -RRB- en-wikipedia-org-9224 204 8 Overnutrition overnutrition NN en-wikipedia-org-9224 204 9 is be VBZ en-wikipedia-org-9224 204 10 associated associate VBN en-wikipedia-org-9224 204 11 with with IN en-wikipedia-org-9224 204 12 diseases disease NNS en-wikipedia-org-9224 204 13 such such JJ en-wikipedia-org-9224 204 14 as as IN en-wikipedia-org-9224 204 15 diabetes diabetes NN en-wikipedia-org-9224 204 16 and and CC en-wikipedia-org-9224 204 17 obesity obesity NN en-wikipedia-org-9224 204 18 , , , en-wikipedia-org-9224 204 19 which which WDT en-wikipedia-org-9224 204 20 are be VBP en-wikipedia-org-9224 204 21 known know VBN en-wikipedia-org-9224 204 22 to to TO en-wikipedia-org-9224 204 23 affect affect VB en-wikipedia-org-9224 204 24 immune immune JJ en-wikipedia-org-9224 204 25 function function NN en-wikipedia-org-9224 204 26 . . . en-wikipedia-org-9224 205 1 More more RBR en-wikipedia-org-9224 205 2 moderate moderate JJ en-wikipedia-org-9224 205 3 malnutrition malnutrition NN en-wikipedia-org-9224 205 4 , , , en-wikipedia-org-9224 205 5 as as RB en-wikipedia-org-9224 205 6 well well RB en-wikipedia-org-9224 205 7 as as IN en-wikipedia-org-9224 205 8 specific specific JJ en-wikipedia-org-9224 205 9 trace trace NN en-wikipedia-org-9224 205 10 mineral mineral NN en-wikipedia-org-9224 205 11 and and CC en-wikipedia-org-9224 205 12 nutrient nutrient NN en-wikipedia-org-9224 205 13 deficiencies deficiency NNS en-wikipedia-org-9224 205 14 , , , en-wikipedia-org-9224 205 15 can can MD en-wikipedia-org-9224 205 16 also also RB en-wikipedia-org-9224 205 17 compromise compromise VB en-wikipedia-org-9224 205 18 the the DT en-wikipedia-org-9224 205 19 immune immune JJ en-wikipedia-org-9224 205 20 response response NN en-wikipedia-org-9224 205 21 . . . en-wikipedia-org-9224 206 1 [ [ -LRB- en-wikipedia-org-9224 206 2 99 99 CD en-wikipedia-org-9224 206 3 ] ] -RRB- en-wikipedia-org-9224 206 4 Foods food NNS en-wikipedia-org-9224 206 5 rich rich JJ en-wikipedia-org-9224 206 6 in in IN en-wikipedia-org-9224 206 7 certain certain JJ en-wikipedia-org-9224 206 8 fatty fatty NN en-wikipedia-org-9224 206 9 acids acid NNS en-wikipedia-org-9224 206 10 may may MD en-wikipedia-org-9224 206 11 foster foster VB en-wikipedia-org-9224 206 12 a a DT en-wikipedia-org-9224 206 13 healthy healthy JJ en-wikipedia-org-9224 206 14 immune immune JJ en-wikipedia-org-9224 206 15 system,[100 system,[100 NNS en-wikipedia-org-9224 206 16 ] ] -RRB- en-wikipedia-org-9224 206 17 and and CC en-wikipedia-org-9224 206 18 fetal fetal JJ en-wikipedia-org-9224 206 19 undernourishment undernourishment NN en-wikipedia-org-9224 206 20 can can MD en-wikipedia-org-9224 206 21 cause cause VB en-wikipedia-org-9224 206 22 a a DT en-wikipedia-org-9224 206 23 lifelong lifelong JJ en-wikipedia-org-9224 206 24 impairment impairment NN en-wikipedia-org-9224 206 25 of of IN en-wikipedia-org-9224 206 26 the the DT en-wikipedia-org-9224 206 27 immune immune JJ en-wikipedia-org-9224 206 28 system system NN en-wikipedia-org-9224 206 29 . . . en-wikipedia-org-9224 207 1 [ [ -LRB- en-wikipedia-org-9224 207 2 101 101 CD en-wikipedia-org-9224 207 3 ] ] -RRB- en-wikipedia-org-9224 207 4 Repair repair NN en-wikipedia-org-9224 207 5 and and CC en-wikipedia-org-9224 207 6 regeneration[edit regeneration[edit LS en-wikipedia-org-9224 207 7 ] ] -RRB- en-wikipedia-org-9224 207 8 The the DT en-wikipedia-org-9224 207 9 immune immune JJ en-wikipedia-org-9224 207 10 system system NN en-wikipedia-org-9224 207 11 , , , en-wikipedia-org-9224 207 12 particularly particularly RB en-wikipedia-org-9224 207 13 the the DT en-wikipedia-org-9224 207 14 innate innate JJ en-wikipedia-org-9224 207 15 component component NN en-wikipedia-org-9224 207 16 , , , en-wikipedia-org-9224 207 17 plays play VBZ en-wikipedia-org-9224 207 18 a a DT en-wikipedia-org-9224 207 19 decisive decisive JJ en-wikipedia-org-9224 207 20 role role NN en-wikipedia-org-9224 207 21 in in IN en-wikipedia-org-9224 207 22 tissue tissue NN en-wikipedia-org-9224 207 23 repair repair NN en-wikipedia-org-9224 207 24 after after IN en-wikipedia-org-9224 207 25 an an DT en-wikipedia-org-9224 207 26 insult insult NN en-wikipedia-org-9224 207 27 . . . en-wikipedia-org-9224 208 1 Key key JJ en-wikipedia-org-9224 208 2 actors actor NNS en-wikipedia-org-9224 208 3 include include VBP en-wikipedia-org-9224 208 4 macrophages macrophage NNS en-wikipedia-org-9224 208 5 and and CC en-wikipedia-org-9224 208 6 neutrophils neutrophil NNS en-wikipedia-org-9224 208 7 , , , en-wikipedia-org-9224 208 8 but but CC en-wikipedia-org-9224 208 9 other other JJ en-wikipedia-org-9224 208 10 cellular cellular JJ en-wikipedia-org-9224 208 11 actors actor NNS en-wikipedia-org-9224 208 12 , , , en-wikipedia-org-9224 208 13 including include VBG en-wikipedia-org-9224 208 14 γδ γδ CC en-wikipedia-org-9224 208 15 T T NNP en-wikipedia-org-9224 208 16 cells cell NNS en-wikipedia-org-9224 208 17 , , , en-wikipedia-org-9224 208 18 innate innate VBP en-wikipedia-org-9224 208 19 lymphoid lymphoid JJ en-wikipedia-org-9224 208 20 cells cell NNS en-wikipedia-org-9224 208 21 ( ( -LRB- en-wikipedia-org-9224 208 22 ILCs ILCs NNP en-wikipedia-org-9224 208 23 ) ) -RRB- en-wikipedia-org-9224 208 24 , , , en-wikipedia-org-9224 208 25 and and CC en-wikipedia-org-9224 208 26 regulatory regulatory JJ en-wikipedia-org-9224 208 27 T t NN en-wikipedia-org-9224 208 28 cells cell NNS en-wikipedia-org-9224 208 29 ( ( -LRB- en-wikipedia-org-9224 208 30 Tregs Tregs NNP en-wikipedia-org-9224 208 31 ) ) -RRB- en-wikipedia-org-9224 208 32 , , , en-wikipedia-org-9224 208 33 are be VBP en-wikipedia-org-9224 208 34 also also RB en-wikipedia-org-9224 208 35 important important JJ en-wikipedia-org-9224 208 36 . . . en-wikipedia-org-9224 209 1 The the DT en-wikipedia-org-9224 209 2 plasticity plasticity NN en-wikipedia-org-9224 209 3 of of IN en-wikipedia-org-9224 209 4 immune immune JJ en-wikipedia-org-9224 209 5 cells cell NNS en-wikipedia-org-9224 209 6 and and CC en-wikipedia-org-9224 209 7 the the DT en-wikipedia-org-9224 209 8 balance balance NN en-wikipedia-org-9224 209 9 between between IN en-wikipedia-org-9224 209 10 pro pro JJ en-wikipedia-org-9224 209 11 - - JJ en-wikipedia-org-9224 209 12 inflammatory inflammatory JJ en-wikipedia-org-9224 209 13 and and CC en-wikipedia-org-9224 209 14 anti anti JJ en-wikipedia-org-9224 209 15 - - JJ en-wikipedia-org-9224 209 16 inflammatory inflammatory JJ en-wikipedia-org-9224 209 17 signals signal NNS en-wikipedia-org-9224 209 18 are be VBP en-wikipedia-org-9224 209 19 crucial crucial JJ en-wikipedia-org-9224 209 20 aspects aspect NNS en-wikipedia-org-9224 209 21 of of IN en-wikipedia-org-9224 209 22 efficient efficient JJ en-wikipedia-org-9224 209 23 tissue tissue NN en-wikipedia-org-9224 209 24 repair repair NN en-wikipedia-org-9224 209 25 . . . en-wikipedia-org-9224 210 1 Immune immune JJ en-wikipedia-org-9224 210 2 components component NNS en-wikipedia-org-9224 210 3 and and CC en-wikipedia-org-9224 210 4 pathways pathway NNS en-wikipedia-org-9224 210 5 are be VBP en-wikipedia-org-9224 210 6 involved involve VBN en-wikipedia-org-9224 210 7 in in IN en-wikipedia-org-9224 210 8 regeneration regeneration NN en-wikipedia-org-9224 210 9 as as RB en-wikipedia-org-9224 210 10 well well RB en-wikipedia-org-9224 210 11 , , , en-wikipedia-org-9224 210 12 for for IN en-wikipedia-org-9224 210 13 example example NN en-wikipedia-org-9224 210 14 in in IN en-wikipedia-org-9224 210 15 amphibians amphibian NNS en-wikipedia-org-9224 210 16 . . . en-wikipedia-org-9224 211 1 According accord VBG en-wikipedia-org-9224 211 2 to to IN en-wikipedia-org-9224 211 3 one one CD en-wikipedia-org-9224 211 4 hypothesis hypothesis NN en-wikipedia-org-9224 211 5 , , , en-wikipedia-org-9224 211 6 organisms organism NNS en-wikipedia-org-9224 211 7 that that WDT en-wikipedia-org-9224 211 8 can can MD en-wikipedia-org-9224 211 9 regenerate regenerate VB en-wikipedia-org-9224 211 10 could could MD en-wikipedia-org-9224 211 11 be be VB en-wikipedia-org-9224 211 12 less less RBR en-wikipedia-org-9224 211 13 immunocompetent immunocompetent JJ en-wikipedia-org-9224 211 14 than than IN en-wikipedia-org-9224 211 15 organisms organism NNS en-wikipedia-org-9224 211 16 that that WDT en-wikipedia-org-9224 211 17 can can MD en-wikipedia-org-9224 211 18 not not RB en-wikipedia-org-9224 211 19 regenerate regenerate VB en-wikipedia-org-9224 211 20 . . . en-wikipedia-org-9224 212 1 [ [ -LRB- en-wikipedia-org-9224 212 2 102 102 CD en-wikipedia-org-9224 212 3 ] ] -RRB- en-wikipedia-org-9224 212 4 Disorders Disorders NNPS en-wikipedia-org-9224 212 5 of of IN en-wikipedia-org-9224 212 6 human human NN en-wikipedia-org-9224 212 7 immunity[edit immunity[edit NN en-wikipedia-org-9224 212 8 ] ] -RRB- en-wikipedia-org-9224 212 9 Failures failure NNS en-wikipedia-org-9224 212 10 of of IN en-wikipedia-org-9224 212 11 host host NN en-wikipedia-org-9224 212 12 defense defense NN en-wikipedia-org-9224 212 13 occur occur VBP en-wikipedia-org-9224 212 14 and and CC en-wikipedia-org-9224 212 15 fall fall VB en-wikipedia-org-9224 212 16 into into IN en-wikipedia-org-9224 212 17 three three CD en-wikipedia-org-9224 212 18 broad broad JJ en-wikipedia-org-9224 212 19 categories category NNS en-wikipedia-org-9224 212 20 : : : en-wikipedia-org-9224 212 21 immunodeficiencies,[103 immunodeficiencies,[103 NNP en-wikipedia-org-9224 212 22 ] ] -RRB- en-wikipedia-org-9224 212 23 autoimmunity,[104 autoimmunity,[104 NN en-wikipedia-org-9224 212 24 ] ] -RRB- en-wikipedia-org-9224 212 25 and and CC en-wikipedia-org-9224 212 26 hypersensitivities hypersensitivity NNS en-wikipedia-org-9224 212 27 . . . en-wikipedia-org-9224 213 1 [ [ -LRB- en-wikipedia-org-9224 213 2 105 105 CD en-wikipedia-org-9224 213 3 ] ] -RRB- en-wikipedia-org-9224 213 4 Immunodeficiencies[edit immunodeficiencies[edit NN en-wikipedia-org-9224 213 5 ] ] -RRB- en-wikipedia-org-9224 213 6 Further further JJ en-wikipedia-org-9224 213 7 information information NN en-wikipedia-org-9224 213 8 : : : en-wikipedia-org-9224 213 9 Immunodeficiency immunodeficiency NN en-wikipedia-org-9224 213 10 Immunodeficiencies Immunodeficiencies NNPS en-wikipedia-org-9224 213 11 occur occur VBP en-wikipedia-org-9224 213 12 when when WRB en-wikipedia-org-9224 213 13 one one CD en-wikipedia-org-9224 213 14 or or CC en-wikipedia-org-9224 213 15 more more JJR en-wikipedia-org-9224 213 16 of of IN en-wikipedia-org-9224 213 17 the the DT en-wikipedia-org-9224 213 18 components component NNS en-wikipedia-org-9224 213 19 of of IN en-wikipedia-org-9224 213 20 the the DT en-wikipedia-org-9224 213 21 immune immune JJ en-wikipedia-org-9224 213 22 system system NN en-wikipedia-org-9224 213 23 are be VBP en-wikipedia-org-9224 213 24 inactive inactive JJ en-wikipedia-org-9224 213 25 . . . en-wikipedia-org-9224 214 1 The the DT en-wikipedia-org-9224 214 2 ability ability NN en-wikipedia-org-9224 214 3 of of IN en-wikipedia-org-9224 214 4 the the DT en-wikipedia-org-9224 214 5 immune immune JJ en-wikipedia-org-9224 214 6 system system NN en-wikipedia-org-9224 214 7 to to TO en-wikipedia-org-9224 214 8 respond respond VB en-wikipedia-org-9224 214 9 to to IN en-wikipedia-org-9224 214 10 pathogens pathogens NNP en-wikipedia-org-9224 214 11 is be VBZ en-wikipedia-org-9224 214 12 diminished diminish VBN en-wikipedia-org-9224 214 13 in in IN en-wikipedia-org-9224 214 14 both both CC en-wikipedia-org-9224 214 15 the the DT en-wikipedia-org-9224 214 16 young young JJ en-wikipedia-org-9224 214 17 and and CC en-wikipedia-org-9224 214 18 the the DT en-wikipedia-org-9224 214 19 elderly elderly JJ en-wikipedia-org-9224 214 20 , , , en-wikipedia-org-9224 214 21 with with IN en-wikipedia-org-9224 214 22 immune immune JJ en-wikipedia-org-9224 214 23 responses response NNS en-wikipedia-org-9224 214 24 beginning begin VBG en-wikipedia-org-9224 214 25 to to TO en-wikipedia-org-9224 214 26 decline decline VB en-wikipedia-org-9224 214 27 at at IN en-wikipedia-org-9224 214 28 around around RB en-wikipedia-org-9224 214 29 50 50 CD en-wikipedia-org-9224 214 30 years year NNS en-wikipedia-org-9224 214 31 of of IN en-wikipedia-org-9224 214 32 age age NN en-wikipedia-org-9224 214 33 due due IN en-wikipedia-org-9224 214 34 to to IN en-wikipedia-org-9224 214 35 immunosenescence immunosenescence NN en-wikipedia-org-9224 214 36 . . . en-wikipedia-org-9224 215 1 [ [ -LRB- en-wikipedia-org-9224 215 2 106][107 106][107 LS en-wikipedia-org-9224 215 3 ] ] -RRB- en-wikipedia-org-9224 215 4 In in IN en-wikipedia-org-9224 215 5 developed develop VBN en-wikipedia-org-9224 215 6 countries country NNS en-wikipedia-org-9224 215 7 , , , en-wikipedia-org-9224 215 8 obesity obesity NN en-wikipedia-org-9224 215 9 , , , en-wikipedia-org-9224 215 10 alcoholism alcoholism NN en-wikipedia-org-9224 215 11 , , , en-wikipedia-org-9224 215 12 and and CC en-wikipedia-org-9224 215 13 drug drug NN en-wikipedia-org-9224 215 14 use use NN en-wikipedia-org-9224 215 15 are be VBP en-wikipedia-org-9224 215 16 common common JJ en-wikipedia-org-9224 215 17 causes cause NNS en-wikipedia-org-9224 215 18 of of IN en-wikipedia-org-9224 215 19 poor poor JJ en-wikipedia-org-9224 215 20 immune immune JJ en-wikipedia-org-9224 215 21 function function NN en-wikipedia-org-9224 215 22 , , , en-wikipedia-org-9224 215 23 while while IN en-wikipedia-org-9224 215 24 malnutrition malnutrition NN en-wikipedia-org-9224 215 25 is be VBZ en-wikipedia-org-9224 215 26 the the DT en-wikipedia-org-9224 215 27 most most RBS en-wikipedia-org-9224 215 28 common common JJ en-wikipedia-org-9224 215 29 cause cause NN en-wikipedia-org-9224 215 30 of of IN en-wikipedia-org-9224 215 31 immunodeficiency immunodeficiency NN en-wikipedia-org-9224 215 32 in in IN en-wikipedia-org-9224 215 33 developing develop VBG en-wikipedia-org-9224 215 34 countries country NNS en-wikipedia-org-9224 215 35 . . . en-wikipedia-org-9224 216 1 [ [ -LRB- en-wikipedia-org-9224 216 2 107 107 LS en-wikipedia-org-9224 216 3 ] ] -RRB- en-wikipedia-org-9224 216 4 Diets diet NNS en-wikipedia-org-9224 216 5 lacking lack VBG en-wikipedia-org-9224 216 6 sufficient sufficient JJ en-wikipedia-org-9224 216 7 protein protein NN en-wikipedia-org-9224 216 8 are be VBP en-wikipedia-org-9224 216 9 associated associate VBN en-wikipedia-org-9224 216 10 with with IN en-wikipedia-org-9224 216 11 impaired impaired JJ en-wikipedia-org-9224 216 12 cell cell NN en-wikipedia-org-9224 216 13 - - HYPH en-wikipedia-org-9224 216 14 mediated mediate VBN en-wikipedia-org-9224 216 15 immunity immunity NN en-wikipedia-org-9224 216 16 , , , en-wikipedia-org-9224 216 17 complement complement JJ en-wikipedia-org-9224 216 18 activity activity NN en-wikipedia-org-9224 216 19 , , , en-wikipedia-org-9224 216 20 phagocyte phagocyte NN en-wikipedia-org-9224 216 21 function function NN en-wikipedia-org-9224 216 22 , , , en-wikipedia-org-9224 216 23 IgA IgA NNP en-wikipedia-org-9224 216 24 antibody antibody NN en-wikipedia-org-9224 216 25 concentrations concentration NNS en-wikipedia-org-9224 216 26 , , , en-wikipedia-org-9224 216 27 and and CC en-wikipedia-org-9224 216 28 cytokine cytokine NN en-wikipedia-org-9224 216 29 production production NN en-wikipedia-org-9224 216 30 . . . en-wikipedia-org-9224 217 1 Additionally additionally RB en-wikipedia-org-9224 217 2 , , , en-wikipedia-org-9224 217 3 the the DT en-wikipedia-org-9224 217 4 loss loss NN en-wikipedia-org-9224 217 5 of of IN en-wikipedia-org-9224 217 6 the the DT en-wikipedia-org-9224 217 7 thymus thymus NN en-wikipedia-org-9224 217 8 at at IN en-wikipedia-org-9224 217 9 an an DT en-wikipedia-org-9224 217 10 early early JJ en-wikipedia-org-9224 217 11 age age NN en-wikipedia-org-9224 217 12 through through IN en-wikipedia-org-9224 217 13 genetic genetic JJ en-wikipedia-org-9224 217 14 mutation mutation NN en-wikipedia-org-9224 217 15 or or CC en-wikipedia-org-9224 217 16 surgical surgical JJ en-wikipedia-org-9224 217 17 removal removal NN en-wikipedia-org-9224 217 18 results result NNS en-wikipedia-org-9224 217 19 in in IN en-wikipedia-org-9224 217 20 severe severe JJ en-wikipedia-org-9224 217 21 immunodeficiency immunodeficiency NN en-wikipedia-org-9224 217 22 and and CC en-wikipedia-org-9224 217 23 a a DT en-wikipedia-org-9224 217 24 high high JJ en-wikipedia-org-9224 217 25 susceptibility susceptibility NN en-wikipedia-org-9224 217 26 to to IN en-wikipedia-org-9224 217 27 infection infection NN en-wikipedia-org-9224 217 28 . . . en-wikipedia-org-9224 218 1 [ [ -LRB- en-wikipedia-org-9224 218 2 108 108 CD en-wikipedia-org-9224 218 3 ] ] -RRB- en-wikipedia-org-9224 218 4 Immunodeficiencies immunodeficiency NNS en-wikipedia-org-9224 218 5 can can MD en-wikipedia-org-9224 218 6 also also RB en-wikipedia-org-9224 218 7 be be VB en-wikipedia-org-9224 218 8 inherited inherit VBN en-wikipedia-org-9224 218 9 or or CC en-wikipedia-org-9224 218 10 ' ' `` en-wikipedia-org-9224 218 11 acquired acquire VBN en-wikipedia-org-9224 218 12 ' ' '' en-wikipedia-org-9224 218 13 . . . en-wikipedia-org-9224 219 1 [ [ -LRB- en-wikipedia-org-9224 219 2 109 109 CD en-wikipedia-org-9224 219 3 ] ] -RRB- en-wikipedia-org-9224 219 4 Severe severe JJ en-wikipedia-org-9224 219 5 combined combine VBN en-wikipedia-org-9224 219 6 immunodeficiency immunodeficiency NN en-wikipedia-org-9224 219 7 is be VBZ en-wikipedia-org-9224 219 8 a a DT en-wikipedia-org-9224 219 9 rare rare JJ en-wikipedia-org-9224 219 10 genetic genetic JJ en-wikipedia-org-9224 219 11 disorder disorder NN en-wikipedia-org-9224 219 12 characterized characterize VBN en-wikipedia-org-9224 219 13 by by IN en-wikipedia-org-9224 219 14 the the DT en-wikipedia-org-9224 219 15 disturbed disturbed JJ en-wikipedia-org-9224 219 16 development development NN en-wikipedia-org-9224 219 17 of of IN en-wikipedia-org-9224 219 18 functional functional JJ en-wikipedia-org-9224 219 19 T T NNP en-wikipedia-org-9224 219 20 cells cell NNS en-wikipedia-org-9224 219 21 and and CC en-wikipedia-org-9224 219 22 B b NN en-wikipedia-org-9224 219 23 cells cell NNS en-wikipedia-org-9224 219 24 caused cause VBN en-wikipedia-org-9224 219 25 by by IN en-wikipedia-org-9224 219 26 numerous numerous JJ en-wikipedia-org-9224 219 27 genetic genetic JJ en-wikipedia-org-9224 219 28 mutations mutation NNS en-wikipedia-org-9224 219 29 . . . en-wikipedia-org-9224 220 1 [ [ -LRB- en-wikipedia-org-9224 220 2 110 110 CD en-wikipedia-org-9224 220 3 ] ] -RRB- en-wikipedia-org-9224 220 4 Chronic chronic JJ en-wikipedia-org-9224 220 5 granulomatous granulomatous JJ en-wikipedia-org-9224 220 6 disease disease NN en-wikipedia-org-9224 220 7 , , , en-wikipedia-org-9224 220 8 where where WRB en-wikipedia-org-9224 220 9 phagocytes phagocyte NNS en-wikipedia-org-9224 220 10 have have VBP en-wikipedia-org-9224 220 11 a a DT en-wikipedia-org-9224 220 12 reduced reduce VBN en-wikipedia-org-9224 220 13 ability ability NN en-wikipedia-org-9224 220 14 to to TO en-wikipedia-org-9224 220 15 destroy destroy VB en-wikipedia-org-9224 220 16 pathogens pathogens NNP en-wikipedia-org-9224 220 17 , , , en-wikipedia-org-9224 220 18 is be VBZ en-wikipedia-org-9224 220 19 an an DT en-wikipedia-org-9224 220 20 example example NN en-wikipedia-org-9224 220 21 of of IN en-wikipedia-org-9224 220 22 an an DT en-wikipedia-org-9224 220 23 inherited inherit VBN en-wikipedia-org-9224 220 24 , , , en-wikipedia-org-9224 220 25 or or CC en-wikipedia-org-9224 220 26 congenital congenital JJ en-wikipedia-org-9224 220 27 , , , en-wikipedia-org-9224 220 28 immunodeficiency immunodeficiency NN en-wikipedia-org-9224 220 29 . . . en-wikipedia-org-9224 221 1 AIDS AIDS NNP en-wikipedia-org-9224 221 2 and and CC en-wikipedia-org-9224 221 3 some some DT en-wikipedia-org-9224 221 4 types type NNS en-wikipedia-org-9224 221 5 of of IN en-wikipedia-org-9224 221 6 cancer cancer NN en-wikipedia-org-9224 221 7 cause cause NN en-wikipedia-org-9224 221 8 acquired acquire VBN en-wikipedia-org-9224 221 9 immunodeficiency immunodeficiency NN en-wikipedia-org-9224 221 10 . . . en-wikipedia-org-9224 222 1 [ [ -LRB- en-wikipedia-org-9224 222 2 111][112 111][112 CD en-wikipedia-org-9224 222 3 ] ] -RRB- en-wikipedia-org-9224 222 4 Autoimmunity[edit Autoimmunity[edit `` en-wikipedia-org-9224 222 5 ] ] -RRB- en-wikipedia-org-9224 222 6 Further further JJ en-wikipedia-org-9224 222 7 information information NN en-wikipedia-org-9224 222 8 : : : en-wikipedia-org-9224 222 9 Autoimmunity autoimmunity NN en-wikipedia-org-9224 222 10 Joints Joints NNPS en-wikipedia-org-9224 222 11 of of IN en-wikipedia-org-9224 222 12 a a DT en-wikipedia-org-9224 222 13 hand hand NN en-wikipedia-org-9224 222 14 swollen swollen NN en-wikipedia-org-9224 222 15 and and CC en-wikipedia-org-9224 222 16 deformed deform VBN en-wikipedia-org-9224 222 17 by by IN en-wikipedia-org-9224 222 18 rheumatoid rheumatoid NNP en-wikipedia-org-9224 222 19 arthritis arthritis NNP en-wikipedia-org-9224 222 20 , , , en-wikipedia-org-9224 222 21 an an DT en-wikipedia-org-9224 222 22 autoimmune autoimmune JJ en-wikipedia-org-9224 222 23 disorder disorder NN en-wikipedia-org-9224 222 24 Overactive overactive JJ en-wikipedia-org-9224 222 25 immune immune JJ en-wikipedia-org-9224 222 26 responses response NNS en-wikipedia-org-9224 222 27 form form VBP en-wikipedia-org-9224 222 28 the the DT en-wikipedia-org-9224 222 29 other other JJ en-wikipedia-org-9224 222 30 end end NN en-wikipedia-org-9224 222 31 of of IN en-wikipedia-org-9224 222 32 immune immune JJ en-wikipedia-org-9224 222 33 dysfunction dysfunction NN en-wikipedia-org-9224 222 34 , , , en-wikipedia-org-9224 222 35 particularly particularly RB en-wikipedia-org-9224 222 36 the the DT en-wikipedia-org-9224 222 37 autoimmune autoimmune JJ en-wikipedia-org-9224 222 38 disorders disorder NNS en-wikipedia-org-9224 222 39 . . . en-wikipedia-org-9224 223 1 Here here RB en-wikipedia-org-9224 223 2 , , , en-wikipedia-org-9224 223 3 the the DT en-wikipedia-org-9224 223 4 immune immune JJ en-wikipedia-org-9224 223 5 system system NN en-wikipedia-org-9224 223 6 fails fail VBZ en-wikipedia-org-9224 223 7 to to TO en-wikipedia-org-9224 223 8 properly properly RB en-wikipedia-org-9224 223 9 distinguish distinguish VB en-wikipedia-org-9224 223 10 between between IN en-wikipedia-org-9224 223 11 self self NN en-wikipedia-org-9224 223 12 and and CC en-wikipedia-org-9224 223 13 non non NN en-wikipedia-org-9224 223 14 - - NN en-wikipedia-org-9224 223 15 self self JJ en-wikipedia-org-9224 223 16 , , , en-wikipedia-org-9224 223 17 and and CC en-wikipedia-org-9224 223 18 attacks attack VBZ en-wikipedia-org-9224 223 19 part part NN en-wikipedia-org-9224 223 20 of of IN en-wikipedia-org-9224 223 21 the the DT en-wikipedia-org-9224 223 22 body body NN en-wikipedia-org-9224 223 23 . . . en-wikipedia-org-9224 224 1 Under under IN en-wikipedia-org-9224 224 2 normal normal JJ en-wikipedia-org-9224 224 3 circumstances circumstance NNS en-wikipedia-org-9224 224 4 , , , en-wikipedia-org-9224 224 5 many many JJ en-wikipedia-org-9224 224 6 T t NN en-wikipedia-org-9224 224 7 cells cell NNS en-wikipedia-org-9224 224 8 and and CC en-wikipedia-org-9224 224 9 antibodies antibody NNS en-wikipedia-org-9224 224 10 react react VBP en-wikipedia-org-9224 224 11 with with IN en-wikipedia-org-9224 224 12 " " `` en-wikipedia-org-9224 224 13 self self NN en-wikipedia-org-9224 224 14 " " '' en-wikipedia-org-9224 224 15 peptides peptide NNS en-wikipedia-org-9224 224 16 . . . en-wikipedia-org-9224 225 1 [ [ -LRB- en-wikipedia-org-9224 225 2 113 113 CD en-wikipedia-org-9224 225 3 ] ] -RRB- en-wikipedia-org-9224 225 4 One one CD en-wikipedia-org-9224 225 5 of of IN en-wikipedia-org-9224 225 6 the the DT en-wikipedia-org-9224 225 7 functions function NNS en-wikipedia-org-9224 225 8 of of IN en-wikipedia-org-9224 225 9 specialized specialized JJ en-wikipedia-org-9224 225 10 cells cell NNS en-wikipedia-org-9224 225 11 ( ( -LRB- en-wikipedia-org-9224 225 12 located locate VBN en-wikipedia-org-9224 225 13 in in IN en-wikipedia-org-9224 225 14 the the DT en-wikipedia-org-9224 225 15 thymus thymus NN en-wikipedia-org-9224 225 16 and and CC en-wikipedia-org-9224 225 17 bone bone NN en-wikipedia-org-9224 225 18 marrow marrow NNP en-wikipedia-org-9224 225 19 ) ) -RRB- en-wikipedia-org-9224 225 20 is be VBZ en-wikipedia-org-9224 225 21 to to TO en-wikipedia-org-9224 225 22 present present VB en-wikipedia-org-9224 225 23 young young JJ en-wikipedia-org-9224 225 24 lymphocytes lymphocyte NNS en-wikipedia-org-9224 225 25 with with IN en-wikipedia-org-9224 225 26 self self NN en-wikipedia-org-9224 225 27 antigens antigen NNS en-wikipedia-org-9224 225 28 produced produce VBN en-wikipedia-org-9224 225 29 throughout throughout IN en-wikipedia-org-9224 225 30 the the DT en-wikipedia-org-9224 225 31 body body NN en-wikipedia-org-9224 225 32 and and CC en-wikipedia-org-9224 225 33 to to TO en-wikipedia-org-9224 225 34 eliminate eliminate VB en-wikipedia-org-9224 225 35 those those DT en-wikipedia-org-9224 225 36 cells cell NNS en-wikipedia-org-9224 225 37 that that WDT en-wikipedia-org-9224 225 38 recognize recognize VBP en-wikipedia-org-9224 225 39 self self NN en-wikipedia-org-9224 225 40 - - HYPH en-wikipedia-org-9224 225 41 antigens antigen NNS en-wikipedia-org-9224 225 42 , , , en-wikipedia-org-9224 225 43 preventing prevent VBG en-wikipedia-org-9224 225 44 autoimmunity autoimmunity NN en-wikipedia-org-9224 225 45 . . . en-wikipedia-org-9224 226 1 [ [ -LRB- en-wikipedia-org-9224 226 2 72 72 CD en-wikipedia-org-9224 226 3 ] ] -RRB- en-wikipedia-org-9224 226 4 Common common JJ en-wikipedia-org-9224 226 5 autoimmune autoimmune JJ en-wikipedia-org-9224 226 6 diseases disease NNS en-wikipedia-org-9224 226 7 include include VBP en-wikipedia-org-9224 226 8 Hashimoto Hashimoto NNP en-wikipedia-org-9224 226 9 's 's POS en-wikipedia-org-9224 226 10 thyroiditis,[114 thyroiditis,[114 NNP en-wikipedia-org-9224 226 11 ] ] -RRB- en-wikipedia-org-9224 226 12 rheumatoid rheumatoid NNP en-wikipedia-org-9224 226 13 arthritis,[115 arthritis,[115 NNP en-wikipedia-org-9224 226 14 ] ] -RRB- en-wikipedia-org-9224 226 15 diabetes diabete VBZ en-wikipedia-org-9224 226 16 mellitus mellitus NN en-wikipedia-org-9224 226 17 type type NN en-wikipedia-org-9224 226 18 1,[116 1,[116 CD en-wikipedia-org-9224 226 19 ] ] -RRB- en-wikipedia-org-9224 226 20 and and CC en-wikipedia-org-9224 226 21 systemic systemic JJ en-wikipedia-org-9224 226 22 lupus lupus NNP en-wikipedia-org-9224 226 23 erythematosus erythematosus NNP en-wikipedia-org-9224 226 24 . . . en-wikipedia-org-9224 227 1 [ [ -LRB- en-wikipedia-org-9224 227 2 117 117 CD en-wikipedia-org-9224 227 3 ] ] -RRB- en-wikipedia-org-9224 227 4 Hypersensitivity[edit hypersensitivity[edit NN en-wikipedia-org-9224 227 5 ] ] -RRB- en-wikipedia-org-9224 227 6 Further further JJ en-wikipedia-org-9224 227 7 information information NN en-wikipedia-org-9224 227 8 : : : en-wikipedia-org-9224 227 9 Hypersensitivity Hypersensitivity NNP en-wikipedia-org-9224 227 10 Hypersensitivity Hypersensitivity NNP en-wikipedia-org-9224 227 11 is be VBZ en-wikipedia-org-9224 227 12 an an DT en-wikipedia-org-9224 227 13 immune immune JJ en-wikipedia-org-9224 227 14 response response NN en-wikipedia-org-9224 227 15 that that WDT en-wikipedia-org-9224 227 16 damages damage VBZ en-wikipedia-org-9224 227 17 the the DT en-wikipedia-org-9224 227 18 body body NN en-wikipedia-org-9224 227 19 's 's POS en-wikipedia-org-9224 227 20 own own JJ en-wikipedia-org-9224 227 21 tissues tissue NNS en-wikipedia-org-9224 227 22 . . . en-wikipedia-org-9224 228 1 It -PRON- PRP en-wikipedia-org-9224 228 2 is be VBZ en-wikipedia-org-9224 228 3 divided divide VBN en-wikipedia-org-9224 228 4 into into IN en-wikipedia-org-9224 228 5 four four CD en-wikipedia-org-9224 228 6 classes class NNS en-wikipedia-org-9224 228 7 ( ( -LRB- en-wikipedia-org-9224 228 8 Type Type NNP en-wikipedia-org-9224 228 9 I I NNP en-wikipedia-org-9224 228 10   _SP en-wikipedia-org-9224 228 11 – – : en-wikipedia-org-9224 228 12 IV IV NNP en-wikipedia-org-9224 228 13 ) ) -RRB- en-wikipedia-org-9224 228 14 based base VBN en-wikipedia-org-9224 228 15 on on IN en-wikipedia-org-9224 228 16 the the DT en-wikipedia-org-9224 228 17 mechanisms mechanism NNS en-wikipedia-org-9224 228 18 involved involve VBN en-wikipedia-org-9224 228 19 and and CC en-wikipedia-org-9224 228 20 the the DT en-wikipedia-org-9224 228 21 time time NN en-wikipedia-org-9224 228 22 course course NN en-wikipedia-org-9224 228 23 of of IN en-wikipedia-org-9224 228 24 the the DT en-wikipedia-org-9224 228 25 hypersensitive hypersensitive JJ en-wikipedia-org-9224 228 26 reaction reaction NN en-wikipedia-org-9224 228 27 . . . en-wikipedia-org-9224 229 1 Type type NN en-wikipedia-org-9224 229 2 I -PRON- PRP en-wikipedia-org-9224 229 3 hypersensitivity hypersensitivity NN en-wikipedia-org-9224 229 4 is be VBZ en-wikipedia-org-9224 229 5 an an DT en-wikipedia-org-9224 229 6 immediate immediate JJ en-wikipedia-org-9224 229 7 or or CC en-wikipedia-org-9224 229 8 anaphylactic anaphylactic JJ en-wikipedia-org-9224 229 9 reaction reaction NN en-wikipedia-org-9224 229 10 , , , en-wikipedia-org-9224 229 11 often often RB en-wikipedia-org-9224 229 12 associated associate VBN en-wikipedia-org-9224 229 13 with with IN en-wikipedia-org-9224 229 14 allergy allergy NN en-wikipedia-org-9224 229 15 . . . en-wikipedia-org-9224 230 1 Symptoms symptom NNS en-wikipedia-org-9224 230 2 can can MD en-wikipedia-org-9224 230 3 range range VB en-wikipedia-org-9224 230 4 from from IN en-wikipedia-org-9224 230 5 mild mild JJ en-wikipedia-org-9224 230 6 discomfort discomfort NN en-wikipedia-org-9224 230 7 to to IN en-wikipedia-org-9224 230 8 death death NN en-wikipedia-org-9224 230 9 . . . en-wikipedia-org-9224 231 1 Type type NN en-wikipedia-org-9224 231 2 I -PRON- PRP en-wikipedia-org-9224 231 3 hypersensitivity hypersensitivity NN en-wikipedia-org-9224 231 4 is be VBZ en-wikipedia-org-9224 231 5 mediated mediate VBN en-wikipedia-org-9224 231 6 by by IN en-wikipedia-org-9224 231 7 IgE IgE NNP en-wikipedia-org-9224 231 8 , , , en-wikipedia-org-9224 231 9 which which WDT en-wikipedia-org-9224 231 10 triggers trigger VBZ en-wikipedia-org-9224 231 11 degranulation degranulation NN en-wikipedia-org-9224 231 12 of of IN en-wikipedia-org-9224 231 13 mast mast JJ en-wikipedia-org-9224 231 14 cells cell NNS en-wikipedia-org-9224 231 15 and and CC en-wikipedia-org-9224 231 16 basophils basophil NNS en-wikipedia-org-9224 231 17 when when WRB en-wikipedia-org-9224 231 18 cross cross JJ en-wikipedia-org-9224 231 19 - - VBN en-wikipedia-org-9224 231 20 linked link VBN en-wikipedia-org-9224 231 21 by by IN en-wikipedia-org-9224 231 22 antigen antigen NNP en-wikipedia-org-9224 231 23 . . . en-wikipedia-org-9224 232 1 [ [ -LRB- en-wikipedia-org-9224 232 2 118 118 CD en-wikipedia-org-9224 232 3 ] ] -RRB- en-wikipedia-org-9224 232 4 Type type NN en-wikipedia-org-9224 232 5 II II NNP en-wikipedia-org-9224 232 6 hypersensitivity hypersensitivity NN en-wikipedia-org-9224 232 7 occurs occur VBZ en-wikipedia-org-9224 232 8 when when WRB en-wikipedia-org-9224 232 9 antibodies antibody NNS en-wikipedia-org-9224 232 10 bind bind NN en-wikipedia-org-9224 232 11 to to IN en-wikipedia-org-9224 232 12 antigens antigen NNS en-wikipedia-org-9224 232 13 on on IN en-wikipedia-org-9224 232 14 the the DT en-wikipedia-org-9224 232 15 individual individual NN en-wikipedia-org-9224 232 16 's 's POS en-wikipedia-org-9224 232 17 own own JJ en-wikipedia-org-9224 232 18 cells cell NNS en-wikipedia-org-9224 232 19 , , , en-wikipedia-org-9224 232 20 marking mark VBG en-wikipedia-org-9224 232 21 them -PRON- PRP en-wikipedia-org-9224 232 22 for for IN en-wikipedia-org-9224 232 23 destruction destruction NN en-wikipedia-org-9224 232 24 . . . en-wikipedia-org-9224 233 1 This this DT en-wikipedia-org-9224 233 2 is be VBZ en-wikipedia-org-9224 233 3 also also RB en-wikipedia-org-9224 233 4 called call VBN en-wikipedia-org-9224 233 5 antibody antibody NN en-wikipedia-org-9224 233 6 - - HYPH en-wikipedia-org-9224 233 7 dependent dependent JJ en-wikipedia-org-9224 233 8 ( ( -LRB- en-wikipedia-org-9224 233 9 or or CC en-wikipedia-org-9224 233 10 cytotoxic cytotoxic NN en-wikipedia-org-9224 233 11 ) ) -RRB- en-wikipedia-org-9224 233 12 hypersensitivity hypersensitivity NN en-wikipedia-org-9224 233 13 , , , en-wikipedia-org-9224 233 14 and and CC en-wikipedia-org-9224 233 15 is be VBZ en-wikipedia-org-9224 233 16 mediated mediate VBN en-wikipedia-org-9224 233 17 by by IN en-wikipedia-org-9224 233 18 IgG IgG NNP en-wikipedia-org-9224 233 19 and and CC en-wikipedia-org-9224 233 20 IgM IgM NNP en-wikipedia-org-9224 233 21 antibodies antibody NNS en-wikipedia-org-9224 233 22 . . . en-wikipedia-org-9224 234 1 [ [ -LRB- en-wikipedia-org-9224 234 2 118 118 CD en-wikipedia-org-9224 234 3 ] ] -RRB- en-wikipedia-org-9224 234 4 Immune immune JJ en-wikipedia-org-9224 234 5 complexes complex NNS en-wikipedia-org-9224 234 6 ( ( -LRB- en-wikipedia-org-9224 234 7 aggregations aggregation NNS en-wikipedia-org-9224 234 8 of of IN en-wikipedia-org-9224 234 9 antigens antigen NNS en-wikipedia-org-9224 234 10 , , , en-wikipedia-org-9224 234 11 complement complement JJ en-wikipedia-org-9224 234 12 proteins protein NNS en-wikipedia-org-9224 234 13 , , , en-wikipedia-org-9224 234 14 and and CC en-wikipedia-org-9224 234 15 IgG IgG NNP en-wikipedia-org-9224 234 16 and and CC en-wikipedia-org-9224 234 17 IgM IgM NNP en-wikipedia-org-9224 234 18 antibodies antibody NNS en-wikipedia-org-9224 234 19 ) ) -RRB- en-wikipedia-org-9224 234 20 deposited deposit VBN en-wikipedia-org-9224 234 21 in in IN en-wikipedia-org-9224 234 22 various various JJ en-wikipedia-org-9224 234 23 tissues tissue NNS en-wikipedia-org-9224 234 24 trigger trigger NN en-wikipedia-org-9224 234 25 Type type NN en-wikipedia-org-9224 234 26 III iii CD en-wikipedia-org-9224 234 27 hypersensitivity hypersensitivity NN en-wikipedia-org-9224 234 28 reactions reaction NNS en-wikipedia-org-9224 234 29 . . . en-wikipedia-org-9224 235 1 [ [ -LRB- en-wikipedia-org-9224 235 2 118 118 CD en-wikipedia-org-9224 235 3 ] ] -RRB- en-wikipedia-org-9224 235 4 Type Type NNP en-wikipedia-org-9224 235 5 IV IV NNP en-wikipedia-org-9224 235 6 hypersensitivity hypersensitivity NN en-wikipedia-org-9224 235 7 ( ( -LRB- en-wikipedia-org-9224 235 8 also also RB en-wikipedia-org-9224 235 9 known know VBN en-wikipedia-org-9224 235 10 as as IN en-wikipedia-org-9224 235 11 cell cell NN en-wikipedia-org-9224 235 12 - - HYPH en-wikipedia-org-9224 235 13 mediated mediate VBN en-wikipedia-org-9224 235 14 or or CC en-wikipedia-org-9224 235 15 delayed delay VBN en-wikipedia-org-9224 235 16 type type NN en-wikipedia-org-9224 235 17 hypersensitivity hypersensitivity NN en-wikipedia-org-9224 235 18 ) ) -RRB- en-wikipedia-org-9224 235 19 usually usually RB en-wikipedia-org-9224 235 20 takes take VBZ en-wikipedia-org-9224 235 21 between between IN en-wikipedia-org-9224 235 22 two two CD en-wikipedia-org-9224 235 23 and and CC en-wikipedia-org-9224 235 24 three three CD en-wikipedia-org-9224 235 25 days day NNS en-wikipedia-org-9224 235 26 to to TO en-wikipedia-org-9224 235 27 develop develop VB en-wikipedia-org-9224 235 28 . . . en-wikipedia-org-9224 236 1 Type Type NNP en-wikipedia-org-9224 236 2 IV IV NNP en-wikipedia-org-9224 236 3 reactions reaction NNS en-wikipedia-org-9224 236 4 are be VBP en-wikipedia-org-9224 236 5 involved involve VBN en-wikipedia-org-9224 236 6 in in IN en-wikipedia-org-9224 236 7 many many JJ en-wikipedia-org-9224 236 8 autoimmune autoimmune JJ en-wikipedia-org-9224 236 9 and and CC en-wikipedia-org-9224 236 10 infectious infectious JJ en-wikipedia-org-9224 236 11 diseases disease NNS en-wikipedia-org-9224 236 12 , , , en-wikipedia-org-9224 236 13 but but CC en-wikipedia-org-9224 236 14 may may MD en-wikipedia-org-9224 236 15 also also RB en-wikipedia-org-9224 236 16 involve involve VB en-wikipedia-org-9224 236 17 contact contact NN en-wikipedia-org-9224 236 18 dermatitis dermatitis NN en-wikipedia-org-9224 236 19 . . . en-wikipedia-org-9224 237 1 These these DT en-wikipedia-org-9224 237 2 reactions reaction NNS en-wikipedia-org-9224 237 3 are be VBP en-wikipedia-org-9224 237 4 mediated mediate VBN en-wikipedia-org-9224 237 5 by by IN en-wikipedia-org-9224 237 6 T t NN en-wikipedia-org-9224 237 7 cells cell NNS en-wikipedia-org-9224 237 8 , , , en-wikipedia-org-9224 237 9 monocytes monocyte NNS en-wikipedia-org-9224 237 10 , , , en-wikipedia-org-9224 237 11 and and CC en-wikipedia-org-9224 237 12 macrophages macrophage NNS en-wikipedia-org-9224 237 13 . . . en-wikipedia-org-9224 238 1 [ [ -LRB- en-wikipedia-org-9224 238 2 118 118 CD en-wikipedia-org-9224 238 3 ] ] -RRB- en-wikipedia-org-9224 238 4 Idiopathic Idiopathic NNP en-wikipedia-org-9224 238 5 inflammation[edit inflammation[edit CD en-wikipedia-org-9224 238 6 ] ] -RRB- en-wikipedia-org-9224 238 7 Further further JJ en-wikipedia-org-9224 238 8 information information NN en-wikipedia-org-9224 238 9 : : : en-wikipedia-org-9224 238 10 Immune Immune NNP en-wikipedia-org-9224 238 11 - - HYPH en-wikipedia-org-9224 238 12 mediated mediate VBN en-wikipedia-org-9224 238 13 inflammatory inflammatory JJ en-wikipedia-org-9224 238 14 diseases disease NNS en-wikipedia-org-9224 238 15 Inflammation inflammation NN en-wikipedia-org-9224 238 16 is be VBZ en-wikipedia-org-9224 238 17 one one CD en-wikipedia-org-9224 238 18 of of IN en-wikipedia-org-9224 238 19 the the DT en-wikipedia-org-9224 238 20 first first JJ en-wikipedia-org-9224 238 21 responses response NNS en-wikipedia-org-9224 238 22 of of IN en-wikipedia-org-9224 238 23 the the DT en-wikipedia-org-9224 238 24 immune immune JJ en-wikipedia-org-9224 238 25 system system NN en-wikipedia-org-9224 238 26 to to IN en-wikipedia-org-9224 238 27 infection,[44 infection,[44 ADD en-wikipedia-org-9224 238 28 ] ] -RRB- en-wikipedia-org-9224 238 29 but but CC en-wikipedia-org-9224 238 30 it -PRON- PRP en-wikipedia-org-9224 238 31 can can MD en-wikipedia-org-9224 238 32 appear appear VB en-wikipedia-org-9224 238 33 without without IN en-wikipedia-org-9224 238 34 known know VBN en-wikipedia-org-9224 238 35 cause cause NN en-wikipedia-org-9224 238 36 . . . en-wikipedia-org-9224 239 1 Inflammation inflammation NN en-wikipedia-org-9224 239 2 is be VBZ en-wikipedia-org-9224 239 3 produced produce VBN en-wikipedia-org-9224 239 4 by by IN en-wikipedia-org-9224 239 5 eicosanoids eicosanoid NNS en-wikipedia-org-9224 239 6 and and CC en-wikipedia-org-9224 239 7 cytokines cytokine NNS en-wikipedia-org-9224 239 8 , , , en-wikipedia-org-9224 239 9 which which WDT en-wikipedia-org-9224 239 10 are be VBP en-wikipedia-org-9224 239 11 released release VBN en-wikipedia-org-9224 239 12 by by IN en-wikipedia-org-9224 239 13 injured injured JJ en-wikipedia-org-9224 239 14 or or CC en-wikipedia-org-9224 239 15 infected infected JJ en-wikipedia-org-9224 239 16 cells cell NNS en-wikipedia-org-9224 239 17 . . . en-wikipedia-org-9224 240 1 Eicosanoids eicosanoid NNS en-wikipedia-org-9224 240 2 include include VBP en-wikipedia-org-9224 240 3 prostaglandins prostaglandin NNS en-wikipedia-org-9224 240 4 that that WDT en-wikipedia-org-9224 240 5 produce produce VBP en-wikipedia-org-9224 240 6 fever fever NN en-wikipedia-org-9224 240 7 and and CC en-wikipedia-org-9224 240 8 the the DT en-wikipedia-org-9224 240 9 dilation dilation NN en-wikipedia-org-9224 240 10 of of IN en-wikipedia-org-9224 240 11 blood blood NN en-wikipedia-org-9224 240 12 vessels vessel NNS en-wikipedia-org-9224 240 13 associated associate VBN en-wikipedia-org-9224 240 14 with with IN en-wikipedia-org-9224 240 15 inflammation inflammation NN en-wikipedia-org-9224 240 16 , , , en-wikipedia-org-9224 240 17 and and CC en-wikipedia-org-9224 240 18 leukotrienes leukotriene NNS en-wikipedia-org-9224 240 19 that that WDT en-wikipedia-org-9224 240 20 attract attract VBP en-wikipedia-org-9224 240 21 certain certain JJ en-wikipedia-org-9224 240 22 white white JJ en-wikipedia-org-9224 240 23 blood blood NN en-wikipedia-org-9224 240 24 cells cell NNS en-wikipedia-org-9224 240 25 ( ( -LRB- en-wikipedia-org-9224 240 26 leukocytes leukocyte NNS en-wikipedia-org-9224 240 27 ) ) -RRB- en-wikipedia-org-9224 240 28 . . . en-wikipedia-org-9224 241 1 [ [ -LRB- en-wikipedia-org-9224 241 2 45][46 45][46 LS en-wikipedia-org-9224 241 3 ] ] -RRB- en-wikipedia-org-9224 241 4 Common common JJ en-wikipedia-org-9224 241 5 cytokines cytokine NNS en-wikipedia-org-9224 241 6 include include VBP en-wikipedia-org-9224 241 7 interleukins interleukin NNS en-wikipedia-org-9224 241 8 that that WDT en-wikipedia-org-9224 241 9 are be VBP en-wikipedia-org-9224 241 10 responsible responsible JJ en-wikipedia-org-9224 241 11 for for IN en-wikipedia-org-9224 241 12 communication communication NN en-wikipedia-org-9224 241 13 between between IN en-wikipedia-org-9224 241 14 white white JJ en-wikipedia-org-9224 241 15 blood blood NN en-wikipedia-org-9224 241 16 cells cell NNS en-wikipedia-org-9224 241 17 ; ; , en-wikipedia-org-9224 241 18 chemokines chemokine VBZ en-wikipedia-org-9224 241 19 that that WDT en-wikipedia-org-9224 241 20 promote promote VBP en-wikipedia-org-9224 241 21 chemotaxis chemotaxi NNS en-wikipedia-org-9224 241 22 ; ; : en-wikipedia-org-9224 241 23 and and CC en-wikipedia-org-9224 241 24 interferons interferon NNS en-wikipedia-org-9224 241 25 that that WDT en-wikipedia-org-9224 241 26 have have VBP en-wikipedia-org-9224 241 27 anti anti JJ en-wikipedia-org-9224 241 28 - - JJ en-wikipedia-org-9224 241 29 viral viral JJ en-wikipedia-org-9224 241 30 effects effect NNS en-wikipedia-org-9224 241 31 , , , en-wikipedia-org-9224 241 32 such such JJ en-wikipedia-org-9224 241 33 as as IN en-wikipedia-org-9224 241 34 shutting shut VBG en-wikipedia-org-9224 241 35 down down RP en-wikipedia-org-9224 241 36 protein protein NN en-wikipedia-org-9224 241 37 synthesis synthesis NN en-wikipedia-org-9224 241 38 in in IN en-wikipedia-org-9224 241 39 the the DT en-wikipedia-org-9224 241 40 host host NN en-wikipedia-org-9224 241 41 cell cell NN en-wikipedia-org-9224 241 42 . . . en-wikipedia-org-9224 242 1 [ [ -LRB- en-wikipedia-org-9224 242 2 47 47 CD en-wikipedia-org-9224 242 3 ] ] -RRB- en-wikipedia-org-9224 242 4 Growth growth NN en-wikipedia-org-9224 242 5 factors factor NNS en-wikipedia-org-9224 242 6 and and CC en-wikipedia-org-9224 242 7 cytotoxic cytotoxic NN en-wikipedia-org-9224 242 8 factors factor NNS en-wikipedia-org-9224 242 9 may may MD en-wikipedia-org-9224 242 10 also also RB en-wikipedia-org-9224 242 11 be be VB en-wikipedia-org-9224 242 12 released release VBN en-wikipedia-org-9224 242 13 . . . en-wikipedia-org-9224 243 1 These these DT en-wikipedia-org-9224 243 2 cytokines cytokine NNS en-wikipedia-org-9224 243 3 and and CC en-wikipedia-org-9224 243 4 other other JJ en-wikipedia-org-9224 243 5 chemicals chemical NNS en-wikipedia-org-9224 243 6 recruit recruit VBP en-wikipedia-org-9224 243 7 immune immune JJ en-wikipedia-org-9224 243 8 cells cell NNS en-wikipedia-org-9224 243 9 to to IN en-wikipedia-org-9224 243 10 the the DT en-wikipedia-org-9224 243 11 site site NN en-wikipedia-org-9224 243 12 of of IN en-wikipedia-org-9224 243 13 infection infection NN en-wikipedia-org-9224 243 14 and and CC en-wikipedia-org-9224 243 15 promote promote VB en-wikipedia-org-9224 243 16 healing healing NN en-wikipedia-org-9224 243 17 of of IN en-wikipedia-org-9224 243 18 any any DT en-wikipedia-org-9224 243 19 damaged damaged JJ en-wikipedia-org-9224 243 20 tissue tissue NN en-wikipedia-org-9224 243 21 following follow VBG en-wikipedia-org-9224 243 22 the the DT en-wikipedia-org-9224 243 23 removal removal NN en-wikipedia-org-9224 243 24 of of IN en-wikipedia-org-9224 243 25 pathogens pathogen NNS en-wikipedia-org-9224 243 26 . . . en-wikipedia-org-9224 244 1 [ [ -LRB- en-wikipedia-org-9224 244 2 48 48 CD en-wikipedia-org-9224 244 3 ] ] -RRB- en-wikipedia-org-9224 244 4 Manipulation manipulation NN en-wikipedia-org-9224 244 5 in in IN en-wikipedia-org-9224 244 6 medicine[edit medicine[edit RB en-wikipedia-org-9224 244 7 ] ] -RRB- en-wikipedia-org-9224 244 8 Skeletal skeletal JJ en-wikipedia-org-9224 244 9 structural structural JJ en-wikipedia-org-9224 244 10 formula formula NN en-wikipedia-org-9224 244 11 of of IN en-wikipedia-org-9224 244 12 the the DT en-wikipedia-org-9224 244 13 immunosuppressive immunosuppressive JJ en-wikipedia-org-9224 244 14 drug drug NN en-wikipedia-org-9224 244 15 dexamethasone dexamethasone NN en-wikipedia-org-9224 244 16 The the DT en-wikipedia-org-9224 244 17 immune immune JJ en-wikipedia-org-9224 244 18 response response NN en-wikipedia-org-9224 244 19 can can MD en-wikipedia-org-9224 244 20 be be VB en-wikipedia-org-9224 244 21 manipulated manipulate VBN en-wikipedia-org-9224 244 22 to to TO en-wikipedia-org-9224 244 23 suppress suppress VB en-wikipedia-org-9224 244 24 unwanted unwanted JJ en-wikipedia-org-9224 244 25 responses response NNS en-wikipedia-org-9224 244 26 resulting result VBG en-wikipedia-org-9224 244 27 from from IN en-wikipedia-org-9224 244 28 autoimmunity autoimmunity NN en-wikipedia-org-9224 244 29 , , , en-wikipedia-org-9224 244 30 allergy allergy NN en-wikipedia-org-9224 244 31 , , , en-wikipedia-org-9224 244 32 and and CC en-wikipedia-org-9224 244 33 transplant transplant NN en-wikipedia-org-9224 244 34 rejection rejection NN en-wikipedia-org-9224 244 35 , , , en-wikipedia-org-9224 244 36 and and CC en-wikipedia-org-9224 244 37 to to TO en-wikipedia-org-9224 244 38 stimulate stimulate VB en-wikipedia-org-9224 244 39 protective protective JJ en-wikipedia-org-9224 244 40 responses response NNS en-wikipedia-org-9224 244 41 against against IN en-wikipedia-org-9224 244 42 pathogens pathogen NNS en-wikipedia-org-9224 244 43 that that WDT en-wikipedia-org-9224 244 44 largely largely RB en-wikipedia-org-9224 244 45 elude elude VBP en-wikipedia-org-9224 244 46 the the DT en-wikipedia-org-9224 244 47 immune immune JJ en-wikipedia-org-9224 244 48 system system NN en-wikipedia-org-9224 244 49 ( ( -LRB- en-wikipedia-org-9224 244 50 see see VB en-wikipedia-org-9224 244 51 immunization immunization NN en-wikipedia-org-9224 244 52 ) ) -RRB- en-wikipedia-org-9224 244 53 or or CC en-wikipedia-org-9224 244 54 cancer cancer NN en-wikipedia-org-9224 244 55 . . . en-wikipedia-org-9224 245 1 [ [ -LRB- en-wikipedia-org-9224 245 2 119 119 CD en-wikipedia-org-9224 245 3 ] ] -RRB- en-wikipedia-org-9224 245 4 Immunosuppression[edit immunosuppression[edit NN en-wikipedia-org-9224 245 5 ] ] -RRB- en-wikipedia-org-9224 245 6 Immunosuppressive immunosuppressive JJ en-wikipedia-org-9224 245 7 drugs drug NNS en-wikipedia-org-9224 245 8 are be VBP en-wikipedia-org-9224 245 9 used use VBN en-wikipedia-org-9224 245 10 to to TO en-wikipedia-org-9224 245 11 control control VB en-wikipedia-org-9224 245 12 autoimmune autoimmune JJ en-wikipedia-org-9224 245 13 disorders disorder NNS en-wikipedia-org-9224 245 14 or or CC en-wikipedia-org-9224 245 15 inflammation inflammation NN en-wikipedia-org-9224 245 16 when when WRB en-wikipedia-org-9224 245 17 excessive excessive JJ en-wikipedia-org-9224 245 18 tissue tissue NN en-wikipedia-org-9224 245 19 damage damage NN en-wikipedia-org-9224 245 20 occurs occur VBZ en-wikipedia-org-9224 245 21 , , , en-wikipedia-org-9224 245 22 and and CC en-wikipedia-org-9224 245 23 to to TO en-wikipedia-org-9224 245 24 prevent prevent VB en-wikipedia-org-9224 245 25 rejection rejection NN en-wikipedia-org-9224 245 26 after after IN en-wikipedia-org-9224 245 27 an an DT en-wikipedia-org-9224 245 28 organ organ NN en-wikipedia-org-9224 245 29 transplant transplant NN en-wikipedia-org-9224 245 30 . . . en-wikipedia-org-9224 246 1 [ [ -LRB- en-wikipedia-org-9224 246 2 42][120 42][120 CD en-wikipedia-org-9224 246 3 ] ] -RRB- en-wikipedia-org-9224 246 4 Anti anti JJ en-wikipedia-org-9224 246 5 - - JJ en-wikipedia-org-9224 246 6 inflammatory inflammatory JJ en-wikipedia-org-9224 246 7 drugs drug NNS en-wikipedia-org-9224 246 8 are be VBP en-wikipedia-org-9224 246 9 often often RB en-wikipedia-org-9224 246 10 used use VBN en-wikipedia-org-9224 246 11 to to TO en-wikipedia-org-9224 246 12 control control VB en-wikipedia-org-9224 246 13 the the DT en-wikipedia-org-9224 246 14 effects effect NNS en-wikipedia-org-9224 246 15 of of IN en-wikipedia-org-9224 246 16 inflammation inflammation NN en-wikipedia-org-9224 246 17 . . . en-wikipedia-org-9224 247 1 Glucocorticoids glucocorticoid NNS en-wikipedia-org-9224 247 2 are be VBP en-wikipedia-org-9224 247 3 the the DT en-wikipedia-org-9224 247 4 most most RBS en-wikipedia-org-9224 247 5 powerful powerful JJ en-wikipedia-org-9224 247 6 of of IN en-wikipedia-org-9224 247 7 these these DT en-wikipedia-org-9224 247 8 drugs drug NNS en-wikipedia-org-9224 247 9 and and CC en-wikipedia-org-9224 247 10 can can MD en-wikipedia-org-9224 247 11 have have VB en-wikipedia-org-9224 247 12 many many JJ en-wikipedia-org-9224 247 13 undesirable undesirable JJ en-wikipedia-org-9224 247 14 side side NN en-wikipedia-org-9224 247 15 effects effect NNS en-wikipedia-org-9224 247 16 , , , en-wikipedia-org-9224 247 17 such such JJ en-wikipedia-org-9224 247 18 as as IN en-wikipedia-org-9224 247 19 central central JJ en-wikipedia-org-9224 247 20 obesity obesity NN en-wikipedia-org-9224 247 21 , , , en-wikipedia-org-9224 247 22 hyperglycemia hyperglycemia NN en-wikipedia-org-9224 247 23 , , , en-wikipedia-org-9224 247 24 and and CC en-wikipedia-org-9224 247 25 osteoporosis osteoporosis NN en-wikipedia-org-9224 247 26 . . . en-wikipedia-org-9224 248 1 [ [ -LRB- en-wikipedia-org-9224 248 2 121 121 CD en-wikipedia-org-9224 248 3 ] ] -RRB- en-wikipedia-org-9224 248 4 Their -PRON- PRP$ en-wikipedia-org-9224 248 5 use use NN en-wikipedia-org-9224 248 6 is be VBZ en-wikipedia-org-9224 248 7 tightly tightly RB en-wikipedia-org-9224 248 8 controlled control VBN en-wikipedia-org-9224 248 9 . . . en-wikipedia-org-9224 249 1 Lower low JJR en-wikipedia-org-9224 249 2 doses dose NNS en-wikipedia-org-9224 249 3 of of IN en-wikipedia-org-9224 249 4 anti anti JJ en-wikipedia-org-9224 249 5 - - JJ en-wikipedia-org-9224 249 6 inflammatory inflammatory JJ en-wikipedia-org-9224 249 7 drugs drug NNS en-wikipedia-org-9224 249 8 are be VBP en-wikipedia-org-9224 249 9 often often RB en-wikipedia-org-9224 249 10 used use VBN en-wikipedia-org-9224 249 11 in in IN en-wikipedia-org-9224 249 12 conjunction conjunction NN en-wikipedia-org-9224 249 13 with with IN en-wikipedia-org-9224 249 14 cytotoxic cytotoxic JJ en-wikipedia-org-9224 249 15 or or CC en-wikipedia-org-9224 249 16 immunosuppressive immunosuppressive JJ en-wikipedia-org-9224 249 17 drugs drug NNS en-wikipedia-org-9224 249 18 such such JJ en-wikipedia-org-9224 249 19 as as IN en-wikipedia-org-9224 249 20 methotrexate methotrexate NN en-wikipedia-org-9224 249 21 or or CC en-wikipedia-org-9224 249 22 azathioprine azathioprine NNP en-wikipedia-org-9224 249 23 . . . en-wikipedia-org-9224 250 1 Cytotoxic cytotoxic JJ en-wikipedia-org-9224 250 2 drugs drug NNS en-wikipedia-org-9224 250 3 inhibit inhibit VBP en-wikipedia-org-9224 250 4 the the DT en-wikipedia-org-9224 250 5 immune immune JJ en-wikipedia-org-9224 250 6 response response NN en-wikipedia-org-9224 250 7 by by IN en-wikipedia-org-9224 250 8 killing kill VBG en-wikipedia-org-9224 250 9 dividing divide VBG en-wikipedia-org-9224 250 10 cells cell NNS en-wikipedia-org-9224 250 11 such such JJ en-wikipedia-org-9224 250 12 as as IN en-wikipedia-org-9224 250 13 activated activate VBN en-wikipedia-org-9224 250 14 T t NN en-wikipedia-org-9224 250 15 cells cell NNS en-wikipedia-org-9224 250 16 . . . en-wikipedia-org-9224 251 1 This this DT en-wikipedia-org-9224 251 2 killing killing NN en-wikipedia-org-9224 251 3 is be VBZ en-wikipedia-org-9224 251 4 indiscriminate indiscriminate JJ en-wikipedia-org-9224 251 5 and and CC en-wikipedia-org-9224 251 6 other other JJ en-wikipedia-org-9224 251 7 constantly constantly RB en-wikipedia-org-9224 251 8 dividing divide VBG en-wikipedia-org-9224 251 9 cells cell NNS en-wikipedia-org-9224 251 10 and and CC en-wikipedia-org-9224 251 11 their -PRON- PRP$ en-wikipedia-org-9224 251 12 organs organ NNS en-wikipedia-org-9224 251 13 are be VBP en-wikipedia-org-9224 251 14 affected affect VBN en-wikipedia-org-9224 251 15 , , , en-wikipedia-org-9224 251 16 which which WDT en-wikipedia-org-9224 251 17 causes cause VBZ en-wikipedia-org-9224 251 18 toxic toxic JJ en-wikipedia-org-9224 251 19 side side NN en-wikipedia-org-9224 251 20 effects effect NNS en-wikipedia-org-9224 251 21 . . . en-wikipedia-org-9224 252 1 [ [ -LRB- en-wikipedia-org-9224 252 2 120 120 CD en-wikipedia-org-9224 252 3 ] ] -RRB- en-wikipedia-org-9224 252 4 Immunosuppressive immunosuppressive JJ en-wikipedia-org-9224 252 5 drugs drug NNS en-wikipedia-org-9224 252 6 such such JJ en-wikipedia-org-9224 252 7 as as IN en-wikipedia-org-9224 252 8 cyclosporin cyclosporin NN en-wikipedia-org-9224 252 9 prevent prevent NN en-wikipedia-org-9224 252 10 T T NNP en-wikipedia-org-9224 252 11 cells cell NNS en-wikipedia-org-9224 252 12 from from IN en-wikipedia-org-9224 252 13 responding respond VBG en-wikipedia-org-9224 252 14 to to IN en-wikipedia-org-9224 252 15 signals signal NNS en-wikipedia-org-9224 252 16 correctly correctly RB en-wikipedia-org-9224 252 17 by by IN en-wikipedia-org-9224 252 18 inhibiting inhibit VBG en-wikipedia-org-9224 252 19 signal signal NN en-wikipedia-org-9224 252 20 transduction transduction NN en-wikipedia-org-9224 252 21 pathways pathway NNS en-wikipedia-org-9224 252 22 . . . en-wikipedia-org-9224 253 1 [ [ -LRB- en-wikipedia-org-9224 253 2 122 122 CD en-wikipedia-org-9224 253 3 ] ] -RRB- en-wikipedia-org-9224 253 4 Immunostimulation[edit immunostimulation[edit NN en-wikipedia-org-9224 253 5 ] ] -RRB- en-wikipedia-org-9224 253 6 Main main JJ en-wikipedia-org-9224 253 7 articles article NNS en-wikipedia-org-9224 253 8 : : : en-wikipedia-org-9224 253 9 Immunotherapy Immunotherapy NNP en-wikipedia-org-9224 253 10 and and CC en-wikipedia-org-9224 253 11 Vaccination Vaccination NNP en-wikipedia-org-9224 253 12 Vaccination[edit vaccination[edit NN en-wikipedia-org-9224 253 13 ] ] -RRB- en-wikipedia-org-9224 253 14 Polio Polio NNP en-wikipedia-org-9224 253 15 vaccination vaccination NN en-wikipedia-org-9224 253 16 in in IN en-wikipedia-org-9224 253 17 Egypt Egypt NNP en-wikipedia-org-9224 253 18 Long Long NNP en-wikipedia-org-9224 253 19 - - HYPH en-wikipedia-org-9224 253 20 term term NN en-wikipedia-org-9224 253 21 active active JJ en-wikipedia-org-9224 253 22 memory memory NN en-wikipedia-org-9224 253 23 is be VBZ en-wikipedia-org-9224 253 24 acquired acquire VBN en-wikipedia-org-9224 253 25 following follow VBG en-wikipedia-org-9224 253 26 infection infection NN en-wikipedia-org-9224 253 27 by by IN en-wikipedia-org-9224 253 28 activation activation NN en-wikipedia-org-9224 253 29 of of IN en-wikipedia-org-9224 253 30 B b NN en-wikipedia-org-9224 253 31 and and CC en-wikipedia-org-9224 253 32 T T NNP en-wikipedia-org-9224 253 33 cells cell NNS en-wikipedia-org-9224 253 34 . . . en-wikipedia-org-9224 254 1 Active active JJ en-wikipedia-org-9224 254 2 immunity immunity NN en-wikipedia-org-9224 254 3 can can MD en-wikipedia-org-9224 254 4 also also RB en-wikipedia-org-9224 254 5 be be VB en-wikipedia-org-9224 254 6 generated generate VBN en-wikipedia-org-9224 254 7 artificially artificially RB en-wikipedia-org-9224 254 8 , , , en-wikipedia-org-9224 254 9 through through IN en-wikipedia-org-9224 254 10 vaccination vaccination NN en-wikipedia-org-9224 254 11 . . . en-wikipedia-org-9224 255 1 The the DT en-wikipedia-org-9224 255 2 principle principle NN en-wikipedia-org-9224 255 3 behind behind IN en-wikipedia-org-9224 255 4 vaccination vaccination NN en-wikipedia-org-9224 255 5 ( ( -LRB- en-wikipedia-org-9224 255 6 also also RB en-wikipedia-org-9224 255 7 called call VBN en-wikipedia-org-9224 255 8 immunization immunization NN en-wikipedia-org-9224 255 9 ) ) -RRB- en-wikipedia-org-9224 255 10 is be VBZ en-wikipedia-org-9224 255 11 to to TO en-wikipedia-org-9224 255 12 introduce introduce VB en-wikipedia-org-9224 255 13 an an DT en-wikipedia-org-9224 255 14 antigen antigen NN en-wikipedia-org-9224 255 15 from from IN en-wikipedia-org-9224 255 16 a a DT en-wikipedia-org-9224 255 17 pathogen pathogen NN en-wikipedia-org-9224 255 18 to to TO en-wikipedia-org-9224 255 19 stimulate stimulate VB en-wikipedia-org-9224 255 20 the the DT en-wikipedia-org-9224 255 21 immune immune JJ en-wikipedia-org-9224 255 22 system system NN en-wikipedia-org-9224 255 23 and and CC en-wikipedia-org-9224 255 24 develop develop VB en-wikipedia-org-9224 255 25 specific specific JJ en-wikipedia-org-9224 255 26 immunity immunity NN en-wikipedia-org-9224 255 27 against against IN en-wikipedia-org-9224 255 28 that that DT en-wikipedia-org-9224 255 29 particular particular JJ en-wikipedia-org-9224 255 30 pathogen pathogen NN en-wikipedia-org-9224 255 31 without without IN en-wikipedia-org-9224 255 32 causing cause VBG en-wikipedia-org-9224 255 33 disease disease NN en-wikipedia-org-9224 255 34 associated associate VBN en-wikipedia-org-9224 255 35 with with IN en-wikipedia-org-9224 255 36 that that DT en-wikipedia-org-9224 255 37 organism organism NN en-wikipedia-org-9224 255 38 . . . en-wikipedia-org-9224 256 1 [ [ -LRB- en-wikipedia-org-9224 256 2 123 123 CD en-wikipedia-org-9224 256 3 ] ] -RRB- en-wikipedia-org-9224 256 4 This this DT en-wikipedia-org-9224 256 5 deliberate deliberate JJ en-wikipedia-org-9224 256 6 induction induction NN en-wikipedia-org-9224 256 7 of of IN en-wikipedia-org-9224 256 8 an an DT en-wikipedia-org-9224 256 9 immune immune JJ en-wikipedia-org-9224 256 10 response response NN en-wikipedia-org-9224 256 11 is be VBZ en-wikipedia-org-9224 256 12 successful successful JJ en-wikipedia-org-9224 256 13 because because IN en-wikipedia-org-9224 256 14 it -PRON- PRP en-wikipedia-org-9224 256 15 exploits exploit VBZ en-wikipedia-org-9224 256 16 the the DT en-wikipedia-org-9224 256 17 natural natural JJ en-wikipedia-org-9224 256 18 specificity specificity NN en-wikipedia-org-9224 256 19 of of IN en-wikipedia-org-9224 256 20 the the DT en-wikipedia-org-9224 256 21 immune immune JJ en-wikipedia-org-9224 256 22 system system NN en-wikipedia-org-9224 256 23 , , , en-wikipedia-org-9224 256 24 as as RB en-wikipedia-org-9224 256 25 well well RB en-wikipedia-org-9224 256 26 as as IN en-wikipedia-org-9224 256 27 its -PRON- PRP$ en-wikipedia-org-9224 256 28 inducibility inducibility NN en-wikipedia-org-9224 256 29 . . . en-wikipedia-org-9224 257 1 With with IN en-wikipedia-org-9224 257 2 infectious infectious JJ en-wikipedia-org-9224 257 3 disease disease NN en-wikipedia-org-9224 257 4 remaining remain VBG en-wikipedia-org-9224 257 5 one one CD en-wikipedia-org-9224 257 6 of of IN en-wikipedia-org-9224 257 7 the the DT en-wikipedia-org-9224 257 8 leading lead VBG en-wikipedia-org-9224 257 9 causes cause NNS en-wikipedia-org-9224 257 10 of of IN en-wikipedia-org-9224 257 11 death death NN en-wikipedia-org-9224 257 12 in in IN en-wikipedia-org-9224 257 13 the the DT en-wikipedia-org-9224 257 14 human human JJ en-wikipedia-org-9224 257 15 population population NN en-wikipedia-org-9224 257 16 , , , en-wikipedia-org-9224 257 17 vaccination vaccination NN en-wikipedia-org-9224 257 18 represents represent VBZ en-wikipedia-org-9224 257 19 the the DT en-wikipedia-org-9224 257 20 most most RBS en-wikipedia-org-9224 257 21 effective effective JJ en-wikipedia-org-9224 257 22 manipulation manipulation NN en-wikipedia-org-9224 257 23 of of IN en-wikipedia-org-9224 257 24 the the DT en-wikipedia-org-9224 257 25 immune immune JJ en-wikipedia-org-9224 257 26 system system NN en-wikipedia-org-9224 257 27 mankind mankind NN en-wikipedia-org-9224 257 28 has have VBZ en-wikipedia-org-9224 257 29 developed develop VBN en-wikipedia-org-9224 257 30 . . . en-wikipedia-org-9224 258 1 [ [ -LRB- en-wikipedia-org-9224 258 2 42][124 42][124 CD en-wikipedia-org-9224 258 3 ] ] -RRB- en-wikipedia-org-9224 258 4 Many many JJ en-wikipedia-org-9224 258 5 vaccines vaccine NNS en-wikipedia-org-9224 258 6 are be VBP en-wikipedia-org-9224 258 7 based base VBN en-wikipedia-org-9224 258 8 on on IN en-wikipedia-org-9224 258 9 acellular acellular JJ en-wikipedia-org-9224 258 10 components component NNS en-wikipedia-org-9224 258 11 of of IN en-wikipedia-org-9224 258 12 micro micro JJ en-wikipedia-org-9224 258 13 - - HYPH en-wikipedia-org-9224 258 14 organisms organism NNS en-wikipedia-org-9224 258 15 , , , en-wikipedia-org-9224 258 16 including include VBG en-wikipedia-org-9224 258 17 harmless harmless JJ en-wikipedia-org-9224 258 18 toxin toxin NN en-wikipedia-org-9224 258 19 components component NNS en-wikipedia-org-9224 258 20 . . . en-wikipedia-org-9224 259 1 [ [ -LRB- en-wikipedia-org-9224 259 2 123 123 CD en-wikipedia-org-9224 259 3 ] ] -RRB- en-wikipedia-org-9224 259 4 Since since IN en-wikipedia-org-9224 259 5 many many JJ en-wikipedia-org-9224 259 6 antigens antigen NNS en-wikipedia-org-9224 259 7 derived derive VBN en-wikipedia-org-9224 259 8 from from IN en-wikipedia-org-9224 259 9 acellular acellular JJ en-wikipedia-org-9224 259 10 vaccines vaccine NNS en-wikipedia-org-9224 259 11 do do VBP en-wikipedia-org-9224 259 12 not not RB en-wikipedia-org-9224 259 13 strongly strongly RB en-wikipedia-org-9224 259 14 induce induce VB en-wikipedia-org-9224 259 15 the the DT en-wikipedia-org-9224 259 16 adaptive adaptive JJ en-wikipedia-org-9224 259 17 response response NN en-wikipedia-org-9224 259 18 , , , en-wikipedia-org-9224 259 19 most most JJS en-wikipedia-org-9224 259 20 bacterial bacterial JJ en-wikipedia-org-9224 259 21 vaccines vaccine NNS en-wikipedia-org-9224 259 22 are be VBP en-wikipedia-org-9224 259 23 provided provide VBN en-wikipedia-org-9224 259 24 with with IN en-wikipedia-org-9224 259 25 additional additional JJ en-wikipedia-org-9224 259 26 adjuvants adjuvant NNS en-wikipedia-org-9224 259 27 that that WDT en-wikipedia-org-9224 259 28 activate activate VBP en-wikipedia-org-9224 259 29 the the DT en-wikipedia-org-9224 259 30 antigen antigen NN en-wikipedia-org-9224 259 31 - - HYPH en-wikipedia-org-9224 259 32 presenting present VBG en-wikipedia-org-9224 259 33 cells cell NNS en-wikipedia-org-9224 259 34 of of IN en-wikipedia-org-9224 259 35 the the DT en-wikipedia-org-9224 259 36 innate innate JJ en-wikipedia-org-9224 259 37 immune immune JJ en-wikipedia-org-9224 259 38 system system NN en-wikipedia-org-9224 259 39 and and CC en-wikipedia-org-9224 259 40 maximize maximize NN en-wikipedia-org-9224 259 41 immunogenicity immunogenicity NN en-wikipedia-org-9224 259 42 . . . en-wikipedia-org-9224 260 1 [ [ -LRB- en-wikipedia-org-9224 260 2 125 125 CD en-wikipedia-org-9224 260 3 ] ] -RRB- en-wikipedia-org-9224 260 4 Tumor Tumor NNP en-wikipedia-org-9224 260 5 immunology[edit immunology[edit NFP en-wikipedia-org-9224 260 6 ] ] -RRB- en-wikipedia-org-9224 260 7 Further further JJ en-wikipedia-org-9224 260 8 information information NN en-wikipedia-org-9224 260 9 : : : en-wikipedia-org-9224 260 10 Cancer cancer NN en-wikipedia-org-9224 260 11 immunology immunology NN en-wikipedia-org-9224 260 12 Another another DT en-wikipedia-org-9224 260 13 important important JJ en-wikipedia-org-9224 260 14 role role NN en-wikipedia-org-9224 260 15 of of IN en-wikipedia-org-9224 260 16 the the DT en-wikipedia-org-9224 260 17 immune immune JJ en-wikipedia-org-9224 260 18 system system NN en-wikipedia-org-9224 260 19 is be VBZ en-wikipedia-org-9224 260 20 to to TO en-wikipedia-org-9224 260 21 identify identify VB en-wikipedia-org-9224 260 22 and and CC en-wikipedia-org-9224 260 23 eliminate eliminate VB en-wikipedia-org-9224 260 24 tumors tumor NNS en-wikipedia-org-9224 260 25 . . . en-wikipedia-org-9224 261 1 This this DT en-wikipedia-org-9224 261 2 is be VBZ en-wikipedia-org-9224 261 3 called call VBN en-wikipedia-org-9224 261 4 immune immune JJ en-wikipedia-org-9224 261 5 surveillance surveillance NN en-wikipedia-org-9224 261 6 . . . en-wikipedia-org-9224 262 1 The the DT en-wikipedia-org-9224 262 2 transformed transform VBN en-wikipedia-org-9224 262 3 cells cell NNS en-wikipedia-org-9224 262 4 of of IN en-wikipedia-org-9224 262 5 tumors tumor NNS en-wikipedia-org-9224 262 6 express express VBP en-wikipedia-org-9224 262 7 antigens antigen NNS en-wikipedia-org-9224 262 8 that that WDT en-wikipedia-org-9224 262 9 are be VBP en-wikipedia-org-9224 262 10 not not RB en-wikipedia-org-9224 262 11 found find VBN en-wikipedia-org-9224 262 12 on on IN en-wikipedia-org-9224 262 13 normal normal JJ en-wikipedia-org-9224 262 14 cells cell NNS en-wikipedia-org-9224 262 15 . . . en-wikipedia-org-9224 263 1 To to IN en-wikipedia-org-9224 263 2 the the DT en-wikipedia-org-9224 263 3 immune immune JJ en-wikipedia-org-9224 263 4 system system NN en-wikipedia-org-9224 263 5 , , , en-wikipedia-org-9224 263 6 these these DT en-wikipedia-org-9224 263 7 antigens antigen NNS en-wikipedia-org-9224 263 8 appear appear VBP en-wikipedia-org-9224 263 9 foreign foreign JJ en-wikipedia-org-9224 263 10 , , , en-wikipedia-org-9224 263 11 and and CC en-wikipedia-org-9224 263 12 their -PRON- PRP$ en-wikipedia-org-9224 263 13 presence presence NN en-wikipedia-org-9224 263 14 causes cause VBZ en-wikipedia-org-9224 263 15 immune immune JJ en-wikipedia-org-9224 263 16 cells cell NNS en-wikipedia-org-9224 263 17 to to TO en-wikipedia-org-9224 263 18 attack attack VB en-wikipedia-org-9224 263 19 the the DT en-wikipedia-org-9224 263 20 transformed transform VBN en-wikipedia-org-9224 263 21 tumor tumor NN en-wikipedia-org-9224 263 22 cells cell NNS en-wikipedia-org-9224 263 23 . . . en-wikipedia-org-9224 264 1 The the DT en-wikipedia-org-9224 264 2 antigens antigen NNS en-wikipedia-org-9224 264 3 expressed express VBN en-wikipedia-org-9224 264 4 by by IN en-wikipedia-org-9224 264 5 tumors tumor NNS en-wikipedia-org-9224 264 6 have have VBP en-wikipedia-org-9224 264 7 several several JJ en-wikipedia-org-9224 264 8 sources;[126 sources;[126 : en-wikipedia-org-9224 264 9 ] ] -RRB- en-wikipedia-org-9224 264 10 some some DT en-wikipedia-org-9224 264 11 are be VBP en-wikipedia-org-9224 264 12 derived derive VBN en-wikipedia-org-9224 264 13 from from IN en-wikipedia-org-9224 264 14 oncogenic oncogenic JJ en-wikipedia-org-9224 264 15 viruses virus NNS en-wikipedia-org-9224 264 16 like like IN en-wikipedia-org-9224 264 17 human human JJ en-wikipedia-org-9224 264 18 papillomavirus papillomavirus NN en-wikipedia-org-9224 264 19 , , , en-wikipedia-org-9224 264 20 which which WDT en-wikipedia-org-9224 264 21 causes cause VBZ en-wikipedia-org-9224 264 22 cancer cancer NN en-wikipedia-org-9224 264 23 of of IN en-wikipedia-org-9224 264 24 the the DT en-wikipedia-org-9224 264 25 cervix,[127 cervix,[127 NN en-wikipedia-org-9224 264 26 ] ] -RRB- en-wikipedia-org-9224 264 27 vulva vulva NN en-wikipedia-org-9224 264 28 , , , en-wikipedia-org-9224 264 29 vagina vagina NNP en-wikipedia-org-9224 264 30 , , , en-wikipedia-org-9224 264 31 penis penis NN en-wikipedia-org-9224 264 32 , , , en-wikipedia-org-9224 264 33 anus anus NN en-wikipedia-org-9224 264 34 , , , en-wikipedia-org-9224 264 35 mouth mouth NN en-wikipedia-org-9224 264 36 , , , en-wikipedia-org-9224 264 37 and and CC en-wikipedia-org-9224 264 38 throat,[128 throat,[128 NN en-wikipedia-org-9224 264 39 ] ] -RRB- en-wikipedia-org-9224 264 40 while while IN en-wikipedia-org-9224 264 41 others other NNS en-wikipedia-org-9224 264 42 are be VBP en-wikipedia-org-9224 264 43 the the DT en-wikipedia-org-9224 264 44 organism organism NN en-wikipedia-org-9224 264 45 's 's POS en-wikipedia-org-9224 264 46 own own JJ en-wikipedia-org-9224 264 47 proteins protein NNS en-wikipedia-org-9224 264 48 that that WDT en-wikipedia-org-9224 264 49 occur occur VBP en-wikipedia-org-9224 264 50 at at IN en-wikipedia-org-9224 264 51 low low JJ en-wikipedia-org-9224 264 52 levels level NNS en-wikipedia-org-9224 264 53 in in IN en-wikipedia-org-9224 264 54 normal normal JJ en-wikipedia-org-9224 264 55 cells cell NNS en-wikipedia-org-9224 264 56 but but CC en-wikipedia-org-9224 264 57 reach reach VB en-wikipedia-org-9224 264 58 high high JJ en-wikipedia-org-9224 264 59 levels level NNS en-wikipedia-org-9224 264 60 in in IN en-wikipedia-org-9224 264 61 tumor tumor NN en-wikipedia-org-9224 264 62 cells cell NNS en-wikipedia-org-9224 264 63 . . . en-wikipedia-org-9224 265 1 One one CD en-wikipedia-org-9224 265 2 example example NN en-wikipedia-org-9224 265 3 is be VBZ en-wikipedia-org-9224 265 4 an an DT en-wikipedia-org-9224 265 5 enzyme enzyme NNS en-wikipedia-org-9224 265 6 called call VBN en-wikipedia-org-9224 265 7 tyrosinase tyrosinase NN en-wikipedia-org-9224 265 8 that that DT en-wikipedia-org-9224 265 9 , , , en-wikipedia-org-9224 265 10 when when WRB en-wikipedia-org-9224 265 11 expressed express VBN en-wikipedia-org-9224 265 12 at at IN en-wikipedia-org-9224 265 13 high high JJ en-wikipedia-org-9224 265 14 levels level NNS en-wikipedia-org-9224 265 15 , , , en-wikipedia-org-9224 265 16 transforms transform VBZ en-wikipedia-org-9224 265 17 certain certain JJ en-wikipedia-org-9224 265 18 skin skin NN en-wikipedia-org-9224 265 19 cells cell NNS en-wikipedia-org-9224 265 20 ( ( -LRB- en-wikipedia-org-9224 265 21 for for IN en-wikipedia-org-9224 265 22 example example NN en-wikipedia-org-9224 265 23 , , , en-wikipedia-org-9224 265 24 melanocytes melanocyte NNS en-wikipedia-org-9224 265 25 ) ) -RRB- en-wikipedia-org-9224 265 26 into into IN en-wikipedia-org-9224 265 27 tumors tumor NNS en-wikipedia-org-9224 265 28 called call VBN en-wikipedia-org-9224 265 29 melanomas melanoma NNS en-wikipedia-org-9224 265 30 . . . en-wikipedia-org-9224 266 1 [ [ -LRB- en-wikipedia-org-9224 266 2 129][130 129][130 LS en-wikipedia-org-9224 266 3 ] ] -RRB- en-wikipedia-org-9224 266 4 A a DT en-wikipedia-org-9224 266 5 third third JJ en-wikipedia-org-9224 266 6 possible possible JJ en-wikipedia-org-9224 266 7 source source NN en-wikipedia-org-9224 266 8 of of IN en-wikipedia-org-9224 266 9 tumor tumor NN en-wikipedia-org-9224 266 10 antigens antigen NNS en-wikipedia-org-9224 266 11 are be VBP en-wikipedia-org-9224 266 12 proteins protein NNS en-wikipedia-org-9224 266 13 normally normally RB en-wikipedia-org-9224 266 14 important important JJ en-wikipedia-org-9224 266 15 for for IN en-wikipedia-org-9224 266 16 regulating regulate VBG en-wikipedia-org-9224 266 17 cell cell NN en-wikipedia-org-9224 266 18 growth growth NN en-wikipedia-org-9224 266 19 and and CC en-wikipedia-org-9224 266 20 survival survival NN en-wikipedia-org-9224 266 21 , , , en-wikipedia-org-9224 266 22 that that WDT en-wikipedia-org-9224 266 23 commonly commonly RB en-wikipedia-org-9224 266 24 mutate mutate VBP en-wikipedia-org-9224 266 25 into into IN en-wikipedia-org-9224 266 26 cancer cancer NN en-wikipedia-org-9224 266 27 inducing induce VBG en-wikipedia-org-9224 266 28 molecules molecule NNS en-wikipedia-org-9224 266 29 called call VBN en-wikipedia-org-9224 266 30 oncogenes oncogene NNS en-wikipedia-org-9224 266 31 . . . en-wikipedia-org-9224 267 1 [ [ -LRB- en-wikipedia-org-9224 267 2 126][131][132 126][131][132 CD en-wikipedia-org-9224 267 3 ] ] -RRB- en-wikipedia-org-9224 267 4 Macrophages macrophage NNS en-wikipedia-org-9224 267 5 have have VBP en-wikipedia-org-9224 267 6 identified identify VBN en-wikipedia-org-9224 267 7 a a DT en-wikipedia-org-9224 267 8 cancer cancer NN en-wikipedia-org-9224 267 9 cell cell NN en-wikipedia-org-9224 267 10 ( ( -LRB- en-wikipedia-org-9224 267 11 the the DT en-wikipedia-org-9224 267 12 large large JJ en-wikipedia-org-9224 267 13 , , , en-wikipedia-org-9224 267 14 spiky spiky NNP en-wikipedia-org-9224 267 15 mass mass NN en-wikipedia-org-9224 267 16 ) ) -RRB- en-wikipedia-org-9224 267 17 . . . en-wikipedia-org-9224 268 1 Upon upon IN en-wikipedia-org-9224 268 2 fusing fuse VBG en-wikipedia-org-9224 268 3 with with IN en-wikipedia-org-9224 268 4 the the DT en-wikipedia-org-9224 268 5 cancer cancer NN en-wikipedia-org-9224 268 6 cell cell NN en-wikipedia-org-9224 268 7 , , , en-wikipedia-org-9224 268 8 the the DT en-wikipedia-org-9224 268 9 macrophages macrophage NNS en-wikipedia-org-9224 268 10 ( ( -LRB- en-wikipedia-org-9224 268 11 smaller small JJR en-wikipedia-org-9224 268 12 white white JJ en-wikipedia-org-9224 268 13 cells cell NNS en-wikipedia-org-9224 268 14 ) ) -RRB- en-wikipedia-org-9224 268 15 inject inject VBP en-wikipedia-org-9224 268 16 toxins toxin NNS en-wikipedia-org-9224 268 17 that that WDT en-wikipedia-org-9224 268 18 kill kill VBP en-wikipedia-org-9224 268 19 the the DT en-wikipedia-org-9224 268 20 tumor tumor NN en-wikipedia-org-9224 268 21 cell cell NN en-wikipedia-org-9224 268 22 . . . en-wikipedia-org-9224 269 1 Immunotherapy immunotherapy NN en-wikipedia-org-9224 269 2 for for IN en-wikipedia-org-9224 269 3 the the DT en-wikipedia-org-9224 269 4 treatment treatment NN en-wikipedia-org-9224 269 5 of of IN en-wikipedia-org-9224 269 6 cancer cancer NN en-wikipedia-org-9224 269 7 is be VBZ en-wikipedia-org-9224 269 8 an an DT en-wikipedia-org-9224 269 9 active active JJ en-wikipedia-org-9224 269 10 area area NN en-wikipedia-org-9224 269 11 of of IN en-wikipedia-org-9224 269 12 medical medical JJ en-wikipedia-org-9224 269 13 research research NN en-wikipedia-org-9224 269 14 . . . en-wikipedia-org-9224 270 1 [ [ -LRB- en-wikipedia-org-9224 270 2 133 133 CD en-wikipedia-org-9224 270 3 ] ] -RRB- en-wikipedia-org-9224 270 4 The the DT en-wikipedia-org-9224 270 5 main main JJ en-wikipedia-org-9224 270 6 response response NN en-wikipedia-org-9224 270 7 of of IN en-wikipedia-org-9224 270 8 the the DT en-wikipedia-org-9224 270 9 immune immune JJ en-wikipedia-org-9224 270 10 system system NN en-wikipedia-org-9224 270 11 to to IN en-wikipedia-org-9224 270 12 tumors tumor NNS en-wikipedia-org-9224 270 13 is be VBZ en-wikipedia-org-9224 270 14 to to TO en-wikipedia-org-9224 270 15 destroy destroy VB en-wikipedia-org-9224 270 16 the the DT en-wikipedia-org-9224 270 17 abnormal abnormal JJ en-wikipedia-org-9224 270 18 cells cell NNS en-wikipedia-org-9224 270 19 using use VBG en-wikipedia-org-9224 270 20 killer killer NN en-wikipedia-org-9224 270 21 T t NN en-wikipedia-org-9224 270 22 cells cell NNS en-wikipedia-org-9224 270 23 , , , en-wikipedia-org-9224 270 24 sometimes sometimes RB en-wikipedia-org-9224 270 25 with with IN en-wikipedia-org-9224 270 26 the the DT en-wikipedia-org-9224 270 27 assistance assistance NN en-wikipedia-org-9224 270 28 of of IN en-wikipedia-org-9224 270 29 helper helper NN en-wikipedia-org-9224 270 30 T t NN en-wikipedia-org-9224 270 31 cells cell NNS en-wikipedia-org-9224 270 32 . . . en-wikipedia-org-9224 271 1 [ [ -LRB- en-wikipedia-org-9224 271 2 130][134 130][134 LS en-wikipedia-org-9224 271 3 ] ] -RRB- en-wikipedia-org-9224 271 4 Tumor tumor NN en-wikipedia-org-9224 271 5 antigens antigen NNS en-wikipedia-org-9224 271 6 are be VBP en-wikipedia-org-9224 271 7 presented present VBN en-wikipedia-org-9224 271 8 on on IN en-wikipedia-org-9224 271 9 MHC MHC NNP en-wikipedia-org-9224 271 10 class class NN en-wikipedia-org-9224 271 11 I -PRON- PRP en-wikipedia-org-9224 271 12 molecules molecule VBZ en-wikipedia-org-9224 271 13 in in IN en-wikipedia-org-9224 271 14 a a DT en-wikipedia-org-9224 271 15 similar similar JJ en-wikipedia-org-9224 271 16 way way NN en-wikipedia-org-9224 271 17 to to IN en-wikipedia-org-9224 271 18 viral viral JJ en-wikipedia-org-9224 271 19 antigens antigen NNS en-wikipedia-org-9224 271 20 . . . en-wikipedia-org-9224 272 1 This this DT en-wikipedia-org-9224 272 2 allows allow VBZ en-wikipedia-org-9224 272 3 killer killer NN en-wikipedia-org-9224 272 4 T t NN en-wikipedia-org-9224 272 5 cells cell NNS en-wikipedia-org-9224 272 6 to to TO en-wikipedia-org-9224 272 7 recognize recognize VB en-wikipedia-org-9224 272 8 the the DT en-wikipedia-org-9224 272 9 tumor tumor NN en-wikipedia-org-9224 272 10 cell cell NN en-wikipedia-org-9224 272 11 as as IN en-wikipedia-org-9224 272 12 abnormal abnormal JJ en-wikipedia-org-9224 272 13 . . . en-wikipedia-org-9224 273 1 [ [ -LRB- en-wikipedia-org-9224 273 2 135 135 CD en-wikipedia-org-9224 273 3 ] ] -RRB- en-wikipedia-org-9224 273 4 NK NK NNP en-wikipedia-org-9224 273 5 cells cell NNS en-wikipedia-org-9224 273 6 also also RB en-wikipedia-org-9224 273 7 kill kill VBP en-wikipedia-org-9224 273 8 tumorous tumorous JJ en-wikipedia-org-9224 273 9 cells cell NNS en-wikipedia-org-9224 273 10 in in IN en-wikipedia-org-9224 273 11 a a DT en-wikipedia-org-9224 273 12 similar similar JJ en-wikipedia-org-9224 273 13 way way NN en-wikipedia-org-9224 273 14 , , , en-wikipedia-org-9224 273 15 especially especially RB en-wikipedia-org-9224 273 16 if if IN en-wikipedia-org-9224 273 17 the the DT en-wikipedia-org-9224 273 18 tumor tumor NN en-wikipedia-org-9224 273 19 cells cell NNS en-wikipedia-org-9224 273 20 have have VBP en-wikipedia-org-9224 273 21 fewer few JJR en-wikipedia-org-9224 273 22 MHC MHC NNP en-wikipedia-org-9224 273 23 class class NN en-wikipedia-org-9224 273 24 I -PRON- PRP en-wikipedia-org-9224 273 25 molecules molecule VBZ en-wikipedia-org-9224 273 26 on on IN en-wikipedia-org-9224 273 27 their -PRON- PRP$ en-wikipedia-org-9224 273 28 surface surface NN en-wikipedia-org-9224 273 29 than than IN en-wikipedia-org-9224 273 30 normal normal JJ en-wikipedia-org-9224 273 31 ; ; : en-wikipedia-org-9224 273 32 this this DT en-wikipedia-org-9224 273 33 is be VBZ en-wikipedia-org-9224 273 34 a a DT en-wikipedia-org-9224 273 35 common common JJ en-wikipedia-org-9224 273 36 phenomenon phenomenon NN en-wikipedia-org-9224 273 37 with with IN en-wikipedia-org-9224 273 38 tumors tumor NNS en-wikipedia-org-9224 273 39 . . . en-wikipedia-org-9224 274 1 [ [ -LRB- en-wikipedia-org-9224 274 2 136 136 CD en-wikipedia-org-9224 274 3 ] ] -RRB- en-wikipedia-org-9224 274 4 Sometimes sometimes RB en-wikipedia-org-9224 274 5 antibodies antibody NNS en-wikipedia-org-9224 274 6 are be VBP en-wikipedia-org-9224 274 7 generated generate VBN en-wikipedia-org-9224 274 8 against against IN en-wikipedia-org-9224 274 9 tumor tumor NN en-wikipedia-org-9224 274 10 cells cell NNS en-wikipedia-org-9224 274 11 allowing allow VBG en-wikipedia-org-9224 274 12 for for IN en-wikipedia-org-9224 274 13 their -PRON- PRP$ en-wikipedia-org-9224 274 14 destruction destruction NN en-wikipedia-org-9224 274 15 by by IN en-wikipedia-org-9224 274 16 the the DT en-wikipedia-org-9224 274 17 complement complement NN en-wikipedia-org-9224 274 18 system system NN en-wikipedia-org-9224 274 19 . . . en-wikipedia-org-9224 275 1 [ [ -LRB- en-wikipedia-org-9224 275 2 131 131 CD en-wikipedia-org-9224 275 3 ] ] -RRB- en-wikipedia-org-9224 275 4 Some some DT en-wikipedia-org-9224 275 5 tumors tumor NNS en-wikipedia-org-9224 275 6 evade evade VBP en-wikipedia-org-9224 275 7 the the DT en-wikipedia-org-9224 275 8 immune immune JJ en-wikipedia-org-9224 275 9 system system NN en-wikipedia-org-9224 275 10 and and CC en-wikipedia-org-9224 275 11 go go VB en-wikipedia-org-9224 275 12 on on RP en-wikipedia-org-9224 275 13 to to TO en-wikipedia-org-9224 275 14 become become VB en-wikipedia-org-9224 275 15 cancers cancer NNS en-wikipedia-org-9224 275 16 . . . en-wikipedia-org-9224 276 1 [ [ -LRB- en-wikipedia-org-9224 276 2 137][138 137][138 CD en-wikipedia-org-9224 276 3 ] ] -RRB- en-wikipedia-org-9224 276 4 Tumor tumor NN en-wikipedia-org-9224 276 5 cells cell NNS en-wikipedia-org-9224 276 6 often often RB en-wikipedia-org-9224 276 7 have have VBP en-wikipedia-org-9224 276 8 a a DT en-wikipedia-org-9224 276 9 reduced reduced JJ en-wikipedia-org-9224 276 10 number number NN en-wikipedia-org-9224 276 11 of of IN en-wikipedia-org-9224 276 12 MHC MHC NNP en-wikipedia-org-9224 276 13 class class NN en-wikipedia-org-9224 276 14 I -PRON- PRP en-wikipedia-org-9224 276 15 molecules molecule VBZ en-wikipedia-org-9224 276 16 on on IN en-wikipedia-org-9224 276 17 their -PRON- PRP$ en-wikipedia-org-9224 276 18 surface surface NN en-wikipedia-org-9224 276 19 , , , en-wikipedia-org-9224 276 20 thus thus RB en-wikipedia-org-9224 276 21 avoiding avoid VBG en-wikipedia-org-9224 276 22 detection detection NN en-wikipedia-org-9224 276 23 by by IN en-wikipedia-org-9224 276 24 killer killer NN en-wikipedia-org-9224 276 25 T T NNP en-wikipedia-org-9224 276 26 cells cell NNS en-wikipedia-org-9224 276 27 . . . en-wikipedia-org-9224 277 1 [ [ -LRB- en-wikipedia-org-9224 277 2 135][137 135][137 LS en-wikipedia-org-9224 277 3 ] ] -RRB- en-wikipedia-org-9224 277 4 Some some DT en-wikipedia-org-9224 277 5 tumor tumor NN en-wikipedia-org-9224 277 6 cells cell NNS en-wikipedia-org-9224 277 7 also also RB en-wikipedia-org-9224 277 8 release release VBP en-wikipedia-org-9224 277 9 products product NNS en-wikipedia-org-9224 277 10 that that WDT en-wikipedia-org-9224 277 11 inhibit inhibit VBP en-wikipedia-org-9224 277 12 the the DT en-wikipedia-org-9224 277 13 immune immune JJ en-wikipedia-org-9224 277 14 response response NN en-wikipedia-org-9224 277 15 ; ; : en-wikipedia-org-9224 277 16 for for IN en-wikipedia-org-9224 277 17 example example NN en-wikipedia-org-9224 277 18 by by IN en-wikipedia-org-9224 277 19 secreting secrete VBG en-wikipedia-org-9224 277 20 the the DT en-wikipedia-org-9224 277 21 cytokine cytokine JJ en-wikipedia-org-9224 277 22 TGF TGF NNP en-wikipedia-org-9224 277 23 - - HYPH en-wikipedia-org-9224 277 24 β β NNP en-wikipedia-org-9224 277 25 , , , en-wikipedia-org-9224 277 26 which which WDT en-wikipedia-org-9224 277 27 suppresses suppress VBZ en-wikipedia-org-9224 277 28 the the DT en-wikipedia-org-9224 277 29 activity activity NN en-wikipedia-org-9224 277 30 of of IN en-wikipedia-org-9224 277 31 macrophages macrophage NNS en-wikipedia-org-9224 277 32 and and CC en-wikipedia-org-9224 277 33 lymphocytes lymphocyte NNS en-wikipedia-org-9224 277 34 . . . en-wikipedia-org-9224 278 1 [ [ -LRB- en-wikipedia-org-9224 278 2 137][139 137][139 CD en-wikipedia-org-9224 278 3 ] ] -RRB- en-wikipedia-org-9224 278 4 In in IN en-wikipedia-org-9224 278 5 addition addition NN en-wikipedia-org-9224 278 6 , , , en-wikipedia-org-9224 278 7 immunological immunological JJ en-wikipedia-org-9224 278 8 tolerance tolerance NN en-wikipedia-org-9224 278 9 may may MD en-wikipedia-org-9224 278 10 develop develop VB en-wikipedia-org-9224 278 11 against against IN en-wikipedia-org-9224 278 12 tumor tumor NN en-wikipedia-org-9224 278 13 antigens antigen NNS en-wikipedia-org-9224 278 14 , , , en-wikipedia-org-9224 278 15 so so IN en-wikipedia-org-9224 278 16 the the DT en-wikipedia-org-9224 278 17 immune immune JJ en-wikipedia-org-9224 278 18 system system NN en-wikipedia-org-9224 278 19 no no RB en-wikipedia-org-9224 278 20 longer long RBR en-wikipedia-org-9224 278 21 attacks attack VBZ en-wikipedia-org-9224 278 22 the the DT en-wikipedia-org-9224 278 23 tumor tumor NN en-wikipedia-org-9224 278 24 cells cell NNS en-wikipedia-org-9224 278 25 . . . en-wikipedia-org-9224 279 1 [ [ -LRB- en-wikipedia-org-9224 279 2 137][138 137][138 CD en-wikipedia-org-9224 279 3 ] ] -RRB- en-wikipedia-org-9224 279 4 Paradoxically paradoxically RB en-wikipedia-org-9224 279 5 , , , en-wikipedia-org-9224 279 6 macrophages macrophage NNS en-wikipedia-org-9224 279 7 can can MD en-wikipedia-org-9224 279 8 promote promote VB en-wikipedia-org-9224 279 9 tumor tumor NN en-wikipedia-org-9224 279 10 growth[140 growth[140 NNP en-wikipedia-org-9224 279 11 ] ] -RRB- en-wikipedia-org-9224 279 12 when when WRB en-wikipedia-org-9224 279 13 tumor tumor NN en-wikipedia-org-9224 279 14 cells cell NNS en-wikipedia-org-9224 279 15 send send VBP en-wikipedia-org-9224 279 16 out out RP en-wikipedia-org-9224 279 17 cytokines cytokine NNS en-wikipedia-org-9224 279 18 that that WDT en-wikipedia-org-9224 279 19 attract attract VBP en-wikipedia-org-9224 279 20 macrophages macrophage NNS en-wikipedia-org-9224 279 21 , , , en-wikipedia-org-9224 279 22 which which WDT en-wikipedia-org-9224 279 23 then then RB en-wikipedia-org-9224 279 24 generate generate VBP en-wikipedia-org-9224 279 25 cytokines cytokine NNS en-wikipedia-org-9224 279 26 and and CC en-wikipedia-org-9224 279 27 growth growth NN en-wikipedia-org-9224 279 28 factors factor NNS en-wikipedia-org-9224 279 29 such such JJ en-wikipedia-org-9224 279 30 as as IN en-wikipedia-org-9224 279 31 tumor tumor NN en-wikipedia-org-9224 279 32 - - HYPH en-wikipedia-org-9224 279 33 necrosis necrosis NN en-wikipedia-org-9224 279 34 factor factor NN en-wikipedia-org-9224 279 35 alpha alpha NN en-wikipedia-org-9224 279 36 that that WDT en-wikipedia-org-9224 279 37 nurture nurture VBP en-wikipedia-org-9224 279 38 tumor tumor NN en-wikipedia-org-9224 279 39 development development NN en-wikipedia-org-9224 279 40 or or CC en-wikipedia-org-9224 279 41 promote promote VB en-wikipedia-org-9224 279 42 stem stem NN en-wikipedia-org-9224 279 43 - - HYPH en-wikipedia-org-9224 279 44 cell cell NN en-wikipedia-org-9224 279 45 - - HYPH en-wikipedia-org-9224 279 46 like like JJ en-wikipedia-org-9224 279 47 plasticity plasticity NN en-wikipedia-org-9224 279 48 . . . en-wikipedia-org-9224 280 1 [ [ -LRB- en-wikipedia-org-9224 280 2 137 137 CD en-wikipedia-org-9224 280 3 ] ] -RRB- en-wikipedia-org-9224 280 4 In in IN en-wikipedia-org-9224 280 5 addition addition NN en-wikipedia-org-9224 280 6 , , , en-wikipedia-org-9224 280 7 a a DT en-wikipedia-org-9224 280 8 combination combination NN en-wikipedia-org-9224 280 9 of of IN en-wikipedia-org-9224 280 10 hypoxia hypoxia NNP en-wikipedia-org-9224 280 11 in in IN en-wikipedia-org-9224 280 12 the the DT en-wikipedia-org-9224 280 13 tumor tumor NN en-wikipedia-org-9224 280 14 and and CC en-wikipedia-org-9224 280 15 a a DT en-wikipedia-org-9224 280 16 cytokine cytokine NN en-wikipedia-org-9224 280 17 produced produce VBN en-wikipedia-org-9224 280 18 by by IN en-wikipedia-org-9224 280 19 macrophages macrophages NNP en-wikipedia-org-9224 280 20 induces induces NNPS en-wikipedia-org-9224 280 21 tumor tumor NN en-wikipedia-org-9224 280 22 cells cell NNS en-wikipedia-org-9224 280 23 to to TO en-wikipedia-org-9224 280 24 decrease decrease VB en-wikipedia-org-9224 280 25 production production NN en-wikipedia-org-9224 280 26 of of IN en-wikipedia-org-9224 280 27 a a DT en-wikipedia-org-9224 280 28 protein protein NN en-wikipedia-org-9224 280 29 that that WDT en-wikipedia-org-9224 280 30 blocks block VBZ en-wikipedia-org-9224 280 31 metastasis metastasis NN en-wikipedia-org-9224 280 32 and and CC en-wikipedia-org-9224 280 33 thereby thereby RB en-wikipedia-org-9224 280 34 assists assist NNS en-wikipedia-org-9224 280 35 spread spread VBP en-wikipedia-org-9224 280 36 of of IN en-wikipedia-org-9224 280 37 cancer cancer NN en-wikipedia-org-9224 280 38 cells cell NNS en-wikipedia-org-9224 280 39 . . . en-wikipedia-org-9224 281 1 [ [ -LRB- en-wikipedia-org-9224 281 2 137 137 CD en-wikipedia-org-9224 281 3 ] ] -RRB- en-wikipedia-org-9224 281 4 Anti anti JJ en-wikipedia-org-9224 281 5 - - JJ en-wikipedia-org-9224 281 6 tumor tumor JJ en-wikipedia-org-9224 281 7 M1 M1 NNP en-wikipedia-org-9224 281 8 macrophages macrophage NNS en-wikipedia-org-9224 281 9 are be VBP en-wikipedia-org-9224 281 10 recruited recruit VBN en-wikipedia-org-9224 281 11 in in IN en-wikipedia-org-9224 281 12 early early JJ en-wikipedia-org-9224 281 13 phases phase NNS en-wikipedia-org-9224 281 14 to to TO en-wikipedia-org-9224 281 15 tumor tumor NN en-wikipedia-org-9224 281 16 development development NN en-wikipedia-org-9224 281 17 but but CC en-wikipedia-org-9224 281 18 are be VBP en-wikipedia-org-9224 281 19 progressively progressively RB en-wikipedia-org-9224 281 20 differentiated differentiate VBN en-wikipedia-org-9224 281 21 to to IN en-wikipedia-org-9224 281 22 M2 M2 NNP en-wikipedia-org-9224 281 23 with with IN en-wikipedia-org-9224 281 24 pro pro JJ en-wikipedia-org-9224 281 25 - - JJ en-wikipedia-org-9224 281 26 tumor tumor JJ en-wikipedia-org-9224 281 27 effect effect NN en-wikipedia-org-9224 281 28 , , , en-wikipedia-org-9224 281 29 an an DT en-wikipedia-org-9224 281 30 immunosuppressor immunosuppressor NN en-wikipedia-org-9224 281 31 switch switch NN en-wikipedia-org-9224 281 32 . . . en-wikipedia-org-9224 282 1 The the DT en-wikipedia-org-9224 282 2 hypoxia hypoxia NN en-wikipedia-org-9224 282 3 reduces reduce VBZ en-wikipedia-org-9224 282 4 the the DT en-wikipedia-org-9224 282 5 cytokine cytokine NN en-wikipedia-org-9224 282 6 production production NN en-wikipedia-org-9224 282 7 for for IN en-wikipedia-org-9224 282 8 the the DT en-wikipedia-org-9224 282 9 anti anti JJ en-wikipedia-org-9224 282 10 - - JJ en-wikipedia-org-9224 282 11 tumor tumor JJ en-wikipedia-org-9224 282 12 response response NN en-wikipedia-org-9224 282 13 and and CC en-wikipedia-org-9224 282 14 progressively progressively RB en-wikipedia-org-9224 282 15 macrophages macrophage NNS en-wikipedia-org-9224 282 16 acquire acquire VBP en-wikipedia-org-9224 282 17 pro pro JJ en-wikipedia-org-9224 282 18 - - JJ en-wikipedia-org-9224 282 19 tumor tumor JJ en-wikipedia-org-9224 282 20 M2 M2 NNP en-wikipedia-org-9224 282 21 functions function NNS en-wikipedia-org-9224 282 22 driven drive VBN en-wikipedia-org-9224 282 23 by by IN en-wikipedia-org-9224 282 24 the the DT en-wikipedia-org-9224 282 25 tumor tumor NN en-wikipedia-org-9224 282 26 microenvironment microenvironment NN en-wikipedia-org-9224 282 27 , , , en-wikipedia-org-9224 282 28 including include VBG en-wikipedia-org-9224 282 29 IL-4 IL-4 NNP en-wikipedia-org-9224 282 30 and and CC en-wikipedia-org-9224 282 31 IL-10 IL-10 NNP en-wikipedia-org-9224 282 32 . . . en-wikipedia-org-9224 283 1 [ [ -LRB- en-wikipedia-org-9224 283 2 141 141 CD en-wikipedia-org-9224 283 3 ] ] -RRB- en-wikipedia-org-9224 283 4 Cancer Cancer NNP en-wikipedia-org-9224 283 5 immunotherapy immunotherapy NN en-wikipedia-org-9224 283 6 covers cover VBZ en-wikipedia-org-9224 283 7 the the DT en-wikipedia-org-9224 283 8 medical medical JJ en-wikipedia-org-9224 283 9 ways way NNS en-wikipedia-org-9224 283 10 to to TO en-wikipedia-org-9224 283 11 stimulate stimulate VB en-wikipedia-org-9224 283 12 the the DT en-wikipedia-org-9224 283 13 immune immune JJ en-wikipedia-org-9224 283 14 system system NN en-wikipedia-org-9224 283 15 to to TO en-wikipedia-org-9224 283 16 attack attack VB en-wikipedia-org-9224 283 17 cancer cancer NN en-wikipedia-org-9224 283 18 tumors tumor NNS en-wikipedia-org-9224 283 19 . . . en-wikipedia-org-9224 284 1 [ [ -LRB- en-wikipedia-org-9224 284 2 142 142 CD en-wikipedia-org-9224 284 3 ] ] -RRB- en-wikipedia-org-9224 284 4 Predicting predict VBG en-wikipedia-org-9224 284 5 immunogenicity[edit immunogenicity[edit LS en-wikipedia-org-9224 284 6 ] ] -RRB- en-wikipedia-org-9224 284 7 Some some DT en-wikipedia-org-9224 284 8 drugs drug NNS en-wikipedia-org-9224 284 9 can can MD en-wikipedia-org-9224 284 10 cause cause VB en-wikipedia-org-9224 284 11 a a DT en-wikipedia-org-9224 284 12 neutralizing neutralizing JJ en-wikipedia-org-9224 284 13 immune immune JJ en-wikipedia-org-9224 284 14 response response NN en-wikipedia-org-9224 284 15 , , , en-wikipedia-org-9224 284 16 meaning mean VBG en-wikipedia-org-9224 284 17 that that IN en-wikipedia-org-9224 284 18 the the DT en-wikipedia-org-9224 284 19 immune immune JJ en-wikipedia-org-9224 284 20 system system NN en-wikipedia-org-9224 284 21 produces produce VBZ en-wikipedia-org-9224 284 22 neutralizing neutralize VBG en-wikipedia-org-9224 284 23 antibodies antibody NNS en-wikipedia-org-9224 284 24 that that WDT en-wikipedia-org-9224 284 25 counteract counteract VBP en-wikipedia-org-9224 284 26 the the DT en-wikipedia-org-9224 284 27 action action NN en-wikipedia-org-9224 284 28 of of IN en-wikipedia-org-9224 284 29 the the DT en-wikipedia-org-9224 284 30 drugs drug NNS en-wikipedia-org-9224 284 31 , , , en-wikipedia-org-9224 284 32 particularly particularly RB en-wikipedia-org-9224 284 33 if if IN en-wikipedia-org-9224 284 34 the the DT en-wikipedia-org-9224 284 35 drugs drug NNS en-wikipedia-org-9224 284 36 are be VBP en-wikipedia-org-9224 284 37 administered administer VBN en-wikipedia-org-9224 284 38 repeatedly repeatedly RB en-wikipedia-org-9224 284 39 , , , en-wikipedia-org-9224 284 40 or or CC en-wikipedia-org-9224 284 41 in in IN en-wikipedia-org-9224 284 42 larger large JJR en-wikipedia-org-9224 284 43 doses dose NNS en-wikipedia-org-9224 284 44 . . . en-wikipedia-org-9224 285 1 This this DT en-wikipedia-org-9224 285 2 limits limit VBZ en-wikipedia-org-9224 285 3 the the DT en-wikipedia-org-9224 285 4 effectiveness effectiveness NN en-wikipedia-org-9224 285 5 of of IN en-wikipedia-org-9224 285 6 drugs drug NNS en-wikipedia-org-9224 285 7 based base VBN en-wikipedia-org-9224 285 8 on on IN en-wikipedia-org-9224 285 9 larger large JJR en-wikipedia-org-9224 285 10 peptides peptide NNS en-wikipedia-org-9224 285 11 and and CC en-wikipedia-org-9224 285 12 proteins protein NNS en-wikipedia-org-9224 285 13 ( ( -LRB- en-wikipedia-org-9224 285 14 which which WDT en-wikipedia-org-9224 285 15 are be VBP en-wikipedia-org-9224 285 16 typically typically RB en-wikipedia-org-9224 285 17 larger large JJR en-wikipedia-org-9224 285 18 than than IN en-wikipedia-org-9224 285 19 6000 6000 CD en-wikipedia-org-9224 285 20 Da Da NNP en-wikipedia-org-9224 285 21 ) ) -RRB- en-wikipedia-org-9224 285 22 . . . en-wikipedia-org-9224 286 1 [ [ -LRB- en-wikipedia-org-9224 286 2 143 143 CD en-wikipedia-org-9224 286 3 ] ] -RRB- en-wikipedia-org-9224 286 4 In in IN en-wikipedia-org-9224 286 5 some some DT en-wikipedia-org-9224 286 6 cases case NNS en-wikipedia-org-9224 286 7 , , , en-wikipedia-org-9224 286 8 the the DT en-wikipedia-org-9224 286 9 drug drug NN en-wikipedia-org-9224 286 10 itself -PRON- PRP en-wikipedia-org-9224 286 11 is be VBZ en-wikipedia-org-9224 286 12 not not RB en-wikipedia-org-9224 286 13 immunogenic immunogenic JJ en-wikipedia-org-9224 286 14 , , , en-wikipedia-org-9224 286 15 but but CC en-wikipedia-org-9224 286 16 may may MD en-wikipedia-org-9224 286 17 be be VB en-wikipedia-org-9224 286 18 co co VBN en-wikipedia-org-9224 286 19 - - VBN en-wikipedia-org-9224 286 20 administered administer VBN en-wikipedia-org-9224 286 21 with with IN en-wikipedia-org-9224 286 22 an an DT en-wikipedia-org-9224 286 23 immunogenic immunogenic JJ en-wikipedia-org-9224 286 24 compound compound NN en-wikipedia-org-9224 286 25 , , , en-wikipedia-org-9224 286 26 as as IN en-wikipedia-org-9224 286 27 is be VBZ en-wikipedia-org-9224 286 28 sometimes sometimes RB en-wikipedia-org-9224 286 29 the the DT en-wikipedia-org-9224 286 30 case case NN en-wikipedia-org-9224 286 31 for for IN en-wikipedia-org-9224 286 32 Taxol Taxol NNP en-wikipedia-org-9224 286 33 . . . en-wikipedia-org-9224 287 1 Computational computational JJ en-wikipedia-org-9224 287 2 methods method NNS en-wikipedia-org-9224 287 3 have have VBP en-wikipedia-org-9224 287 4 been be VBN en-wikipedia-org-9224 287 5 developed develop VBN en-wikipedia-org-9224 287 6 to to TO en-wikipedia-org-9224 287 7 predict predict VB en-wikipedia-org-9224 287 8 the the DT en-wikipedia-org-9224 287 9 immunogenicity immunogenicity NN en-wikipedia-org-9224 287 10 of of IN en-wikipedia-org-9224 287 11 peptides peptide NNS en-wikipedia-org-9224 287 12 and and CC en-wikipedia-org-9224 287 13 proteins protein NNS en-wikipedia-org-9224 287 14 , , , en-wikipedia-org-9224 287 15 which which WDT en-wikipedia-org-9224 287 16 are be VBP en-wikipedia-org-9224 287 17 particularly particularly RB en-wikipedia-org-9224 287 18 useful useful JJ en-wikipedia-org-9224 287 19 in in IN en-wikipedia-org-9224 287 20 designing design VBG en-wikipedia-org-9224 287 21 therapeutic therapeutic JJ en-wikipedia-org-9224 287 22 antibodies antibody NNS en-wikipedia-org-9224 287 23 , , , en-wikipedia-org-9224 287 24 assessing assess VBG en-wikipedia-org-9224 287 25 likely likely JJ en-wikipedia-org-9224 287 26 virulence virulence NN en-wikipedia-org-9224 287 27 of of IN en-wikipedia-org-9224 287 28 mutations mutation NNS en-wikipedia-org-9224 287 29 in in IN en-wikipedia-org-9224 287 30 viral viral JJ en-wikipedia-org-9224 287 31 coat coat NN en-wikipedia-org-9224 287 32 particles particle NNS en-wikipedia-org-9224 287 33 , , , en-wikipedia-org-9224 287 34 and and CC en-wikipedia-org-9224 287 35 validation validation NN en-wikipedia-org-9224 287 36 of of IN en-wikipedia-org-9224 287 37 proposed propose VBN en-wikipedia-org-9224 287 38 peptide peptide NN en-wikipedia-org-9224 287 39 - - HYPH en-wikipedia-org-9224 287 40 based base VBN en-wikipedia-org-9224 287 41 drug drug NN en-wikipedia-org-9224 287 42 treatments treatment NNS en-wikipedia-org-9224 287 43 . . . en-wikipedia-org-9224 288 1 Early early JJ en-wikipedia-org-9224 288 2 techniques technique NNS en-wikipedia-org-9224 288 3 relied rely VBD en-wikipedia-org-9224 288 4 mainly mainly RB en-wikipedia-org-9224 288 5 on on IN en-wikipedia-org-9224 288 6 the the DT en-wikipedia-org-9224 288 7 observation observation NN en-wikipedia-org-9224 288 8 that that IN en-wikipedia-org-9224 288 9 hydrophilic hydrophilic JJ en-wikipedia-org-9224 288 10 amino amino NN en-wikipedia-org-9224 288 11 acids acid NNS en-wikipedia-org-9224 288 12 are be VBP en-wikipedia-org-9224 288 13 overrepresented overrepresente VBN en-wikipedia-org-9224 288 14 in in IN en-wikipedia-org-9224 288 15 epitope epitope NN en-wikipedia-org-9224 288 16 regions region NNS en-wikipedia-org-9224 288 17 than than IN en-wikipedia-org-9224 288 18 hydrophobic hydrophobic NN en-wikipedia-org-9224 288 19 amino amino NN en-wikipedia-org-9224 288 20 acids;[144 acids;[144 NNS en-wikipedia-org-9224 288 21 ] ] -RRB- en-wikipedia-org-9224 288 22 however however RB en-wikipedia-org-9224 288 23 , , , en-wikipedia-org-9224 288 24 more more RBR en-wikipedia-org-9224 288 25 recent recent JJ en-wikipedia-org-9224 288 26 developments development NNS en-wikipedia-org-9224 288 27 rely rely VBP en-wikipedia-org-9224 288 28 on on IN en-wikipedia-org-9224 288 29 machine machine NN en-wikipedia-org-9224 288 30 learning learning NN en-wikipedia-org-9224 288 31 techniques technique NNS en-wikipedia-org-9224 288 32 using use VBG en-wikipedia-org-9224 288 33 databases database NNS en-wikipedia-org-9224 288 34 of of IN en-wikipedia-org-9224 288 35 existing exist VBG en-wikipedia-org-9224 288 36 known know VBN en-wikipedia-org-9224 288 37 epitopes epitope NNS en-wikipedia-org-9224 288 38 , , , en-wikipedia-org-9224 288 39 usually usually RB en-wikipedia-org-9224 288 40 on on IN en-wikipedia-org-9224 288 41 well well RB en-wikipedia-org-9224 288 42 - - HYPH en-wikipedia-org-9224 288 43 studied study VBN en-wikipedia-org-9224 288 44 virus virus NN en-wikipedia-org-9224 288 45 proteins protein NNS en-wikipedia-org-9224 288 46 , , , en-wikipedia-org-9224 288 47 as as IN en-wikipedia-org-9224 288 48 a a DT en-wikipedia-org-9224 288 49 training training NN en-wikipedia-org-9224 288 50 set set NN en-wikipedia-org-9224 288 51 . . . en-wikipedia-org-9224 289 1 [ [ -LRB- en-wikipedia-org-9224 289 2 145 145 CD en-wikipedia-org-9224 289 3 ] ] -RRB- en-wikipedia-org-9224 289 4 A a DT en-wikipedia-org-9224 289 5 publicly publicly RB en-wikipedia-org-9224 289 6 accessible accessible JJ en-wikipedia-org-9224 289 7 database database NN en-wikipedia-org-9224 289 8 has have VBZ en-wikipedia-org-9224 289 9 been be VBN en-wikipedia-org-9224 289 10 established establish VBN en-wikipedia-org-9224 289 11 for for IN en-wikipedia-org-9224 289 12 the the DT en-wikipedia-org-9224 289 13 cataloguing cataloguing NN en-wikipedia-org-9224 289 14 of of IN en-wikipedia-org-9224 289 15 epitopes epitope NNS en-wikipedia-org-9224 289 16 from from IN en-wikipedia-org-9224 289 17 pathogens pathogen NNS en-wikipedia-org-9224 289 18 known know VBN en-wikipedia-org-9224 289 19 to to TO en-wikipedia-org-9224 289 20 be be VB en-wikipedia-org-9224 289 21 recognizable recognizable JJ en-wikipedia-org-9224 289 22 by by IN en-wikipedia-org-9224 289 23 B b NN en-wikipedia-org-9224 289 24 cells cell NNS en-wikipedia-org-9224 289 25 . . . en-wikipedia-org-9224 290 1 [ [ -LRB- en-wikipedia-org-9224 290 2 146 146 CD en-wikipedia-org-9224 290 3 ] ] -RRB- en-wikipedia-org-9224 290 4 The the DT en-wikipedia-org-9224 290 5 emerging emerge VBG en-wikipedia-org-9224 290 6 field field NN en-wikipedia-org-9224 290 7 of of IN en-wikipedia-org-9224 290 8 bioinformatics bioinformatic NNS en-wikipedia-org-9224 290 9 - - HYPH en-wikipedia-org-9224 290 10 based base VBN en-wikipedia-org-9224 290 11 studies study NNS en-wikipedia-org-9224 290 12 of of IN en-wikipedia-org-9224 290 13 immunogenicity immunogenicity NN en-wikipedia-org-9224 290 14 is be VBZ en-wikipedia-org-9224 290 15 referred refer VBN en-wikipedia-org-9224 290 16 to to IN en-wikipedia-org-9224 290 17 as as IN en-wikipedia-org-9224 290 18 immunoinformatics immunoinformatic NNS en-wikipedia-org-9224 290 19 . . . en-wikipedia-org-9224 291 1 [ [ -LRB- en-wikipedia-org-9224 291 2 147 147 CD en-wikipedia-org-9224 291 3 ] ] -RRB- en-wikipedia-org-9224 291 4 Immunoproteomics Immunoproteomics NNP en-wikipedia-org-9224 291 5 is be VBZ en-wikipedia-org-9224 291 6 the the DT en-wikipedia-org-9224 291 7 study study NN en-wikipedia-org-9224 291 8 of of IN en-wikipedia-org-9224 291 9 large large JJ en-wikipedia-org-9224 291 10 sets set NNS en-wikipedia-org-9224 291 11 of of IN en-wikipedia-org-9224 291 12 proteins protein NNS en-wikipedia-org-9224 291 13 ( ( -LRB- en-wikipedia-org-9224 291 14 proteomics proteomic NNS en-wikipedia-org-9224 291 15 ) ) -RRB- en-wikipedia-org-9224 291 16 involved involve VBN en-wikipedia-org-9224 291 17 in in IN en-wikipedia-org-9224 291 18 the the DT en-wikipedia-org-9224 291 19 immune immune JJ en-wikipedia-org-9224 291 20 response response NN en-wikipedia-org-9224 291 21 . . . en-wikipedia-org-9224 292 1 [ [ -LRB- en-wikipedia-org-9224 292 2 148 148 CD en-wikipedia-org-9224 292 3 ] ] -RRB- en-wikipedia-org-9224 292 4 Evolution evolution NN en-wikipedia-org-9224 292 5 and and CC en-wikipedia-org-9224 292 6 other other JJ en-wikipedia-org-9224 292 7 mechanisms[edit mechanisms[edit . en-wikipedia-org-9224 292 8 ] ] -RRB- en-wikipedia-org-9224 292 9 Further further JJ en-wikipedia-org-9224 292 10 information information NN en-wikipedia-org-9224 292 11 : : : en-wikipedia-org-9224 292 12 Innate innate VB en-wikipedia-org-9224 292 13 immune immune JJ en-wikipedia-org-9224 292 14 system system NN en-wikipedia-org-9224 292 15 § § -LRB- en-wikipedia-org-9224 292 16   _SP en-wikipedia-org-9224 292 17 Other other JJ en-wikipedia-org-9224 292 18 forms form NNS en-wikipedia-org-9224 292 19 of of IN en-wikipedia-org-9224 292 20 innate innate VBP en-wikipedia-org-9224 292 21 immunity immunity NN en-wikipedia-org-9224 292 22 Evolution evolution NN en-wikipedia-org-9224 292 23 of of IN en-wikipedia-org-9224 292 24 the the DT en-wikipedia-org-9224 292 25 immune immune NN en-wikipedia-org-9224 292 26 system[edit system[edit . en-wikipedia-org-9224 292 27 ] ] -RRB- en-wikipedia-org-9224 292 28 It -PRON- PRP en-wikipedia-org-9224 292 29 is be VBZ en-wikipedia-org-9224 292 30 likely likely JJ en-wikipedia-org-9224 292 31 that that IN en-wikipedia-org-9224 292 32 a a DT en-wikipedia-org-9224 292 33 multicomponent multicomponent NN en-wikipedia-org-9224 292 34 , , , en-wikipedia-org-9224 292 35 adaptive adaptive JJ en-wikipedia-org-9224 292 36 immune immune JJ en-wikipedia-org-9224 292 37 system system NN en-wikipedia-org-9224 292 38 arose arise VBD en-wikipedia-org-9224 292 39 with with IN en-wikipedia-org-9224 292 40 the the DT en-wikipedia-org-9224 292 41 first first JJ en-wikipedia-org-9224 292 42 vertebrates vertebrate NNS en-wikipedia-org-9224 292 43 , , , en-wikipedia-org-9224 292 44 as as IN en-wikipedia-org-9224 292 45 invertebrates invertebrates NNPS en-wikipedia-org-9224 292 46 do do VBP en-wikipedia-org-9224 292 47 not not RB en-wikipedia-org-9224 292 48 generate generate VB en-wikipedia-org-9224 292 49 lymphocytes lymphocyte NNS en-wikipedia-org-9224 292 50 or or CC en-wikipedia-org-9224 292 51 an an DT en-wikipedia-org-9224 292 52 antibody antibody NN en-wikipedia-org-9224 292 53 - - HYPH en-wikipedia-org-9224 292 54 based base VBN en-wikipedia-org-9224 292 55 humoral humoral JJ en-wikipedia-org-9224 292 56 response response NN en-wikipedia-org-9224 292 57 . . . en-wikipedia-org-9224 293 1 [ [ -LRB- en-wikipedia-org-9224 293 2 149 149 CD en-wikipedia-org-9224 293 3 ] ] -RRB- en-wikipedia-org-9224 293 4 Many many JJ en-wikipedia-org-9224 293 5 species specie NNS en-wikipedia-org-9224 293 6 , , , en-wikipedia-org-9224 293 7 however however RB en-wikipedia-org-9224 293 8 , , , en-wikipedia-org-9224 293 9 use use VB en-wikipedia-org-9224 293 10 mechanisms mechanism NNS en-wikipedia-org-9224 293 11 that that WDT en-wikipedia-org-9224 293 12 appear appear VBP en-wikipedia-org-9224 293 13 to to TO en-wikipedia-org-9224 293 14 be be VB en-wikipedia-org-9224 293 15 precursors precursor NNS en-wikipedia-org-9224 293 16 of of IN en-wikipedia-org-9224 293 17 these these DT en-wikipedia-org-9224 293 18 aspects aspect NNS en-wikipedia-org-9224 293 19 of of IN en-wikipedia-org-9224 293 20 vertebrate vertebrate NN en-wikipedia-org-9224 293 21 immunity immunity NN en-wikipedia-org-9224 293 22 . . . en-wikipedia-org-9224 294 1 Immune immune JJ en-wikipedia-org-9224 294 2 systems system NNS en-wikipedia-org-9224 294 3 appear appear VBP en-wikipedia-org-9224 294 4 even even RB en-wikipedia-org-9224 294 5 in in IN en-wikipedia-org-9224 294 6 the the DT en-wikipedia-org-9224 294 7 structurally structurally RB en-wikipedia-org-9224 294 8 simplest simple JJS en-wikipedia-org-9224 294 9 forms form NNS en-wikipedia-org-9224 294 10 of of IN en-wikipedia-org-9224 294 11 life life NN en-wikipedia-org-9224 294 12 , , , en-wikipedia-org-9224 294 13 with with IN en-wikipedia-org-9224 294 14 bacteria bacteria NNS en-wikipedia-org-9224 294 15 using use VBG en-wikipedia-org-9224 294 16 a a DT en-wikipedia-org-9224 294 17 unique unique JJ en-wikipedia-org-9224 294 18 defense defense NN en-wikipedia-org-9224 294 19 mechanism mechanism NN en-wikipedia-org-9224 294 20 , , , en-wikipedia-org-9224 294 21 called call VBD en-wikipedia-org-9224 294 22 the the DT en-wikipedia-org-9224 294 23 restriction restriction NN en-wikipedia-org-9224 294 24 modification modification NN en-wikipedia-org-9224 294 25 system system NN en-wikipedia-org-9224 294 26 to to TO en-wikipedia-org-9224 294 27 protect protect VB en-wikipedia-org-9224 294 28 themselves -PRON- PRP en-wikipedia-org-9224 294 29 from from IN en-wikipedia-org-9224 294 30 viral viral JJ en-wikipedia-org-9224 294 31 pathogens pathogen NNS en-wikipedia-org-9224 294 32 , , , en-wikipedia-org-9224 294 33 called call VBD en-wikipedia-org-9224 294 34 bacteriophages bacteriophage NNS en-wikipedia-org-9224 294 35 . . . en-wikipedia-org-9224 295 1 [ [ -LRB- en-wikipedia-org-9224 295 2 150 150 CD en-wikipedia-org-9224 295 3 ] ] -RRB- en-wikipedia-org-9224 295 4 Prokaryotes Prokaryotes NNPS en-wikipedia-org-9224 295 5 also also RB en-wikipedia-org-9224 295 6 possess possess VBP en-wikipedia-org-9224 295 7 acquired acquire VBN en-wikipedia-org-9224 295 8 immunity immunity NN en-wikipedia-org-9224 295 9 , , , en-wikipedia-org-9224 295 10 through through IN en-wikipedia-org-9224 295 11 a a DT en-wikipedia-org-9224 295 12 system system NN en-wikipedia-org-9224 295 13 that that WDT en-wikipedia-org-9224 295 14 uses use VBZ en-wikipedia-org-9224 295 15 CRISPR CRISPR NNP en-wikipedia-org-9224 295 16 sequences sequence NNS en-wikipedia-org-9224 295 17 to to TO en-wikipedia-org-9224 295 18 retain retain VB en-wikipedia-org-9224 295 19 fragments fragment NNS en-wikipedia-org-9224 295 20 of of IN en-wikipedia-org-9224 295 21 the the DT en-wikipedia-org-9224 295 22 genomes genome NNS en-wikipedia-org-9224 295 23 of of IN en-wikipedia-org-9224 295 24 phage phage NN en-wikipedia-org-9224 295 25 that that WDT en-wikipedia-org-9224 295 26 they -PRON- PRP en-wikipedia-org-9224 295 27 have have VBP en-wikipedia-org-9224 295 28 come come VBN en-wikipedia-org-9224 295 29 into into IN en-wikipedia-org-9224 295 30 contact contact NN en-wikipedia-org-9224 295 31 with with IN en-wikipedia-org-9224 295 32 in in IN en-wikipedia-org-9224 295 33 the the DT en-wikipedia-org-9224 295 34 past past NN en-wikipedia-org-9224 295 35 , , , en-wikipedia-org-9224 295 36 which which WDT en-wikipedia-org-9224 295 37 allows allow VBZ en-wikipedia-org-9224 295 38 them -PRON- PRP en-wikipedia-org-9224 295 39 to to TO en-wikipedia-org-9224 295 40 block block VB en-wikipedia-org-9224 295 41 virus virus NN en-wikipedia-org-9224 295 42 replication replication NN en-wikipedia-org-9224 295 43 through through IN en-wikipedia-org-9224 295 44 a a DT en-wikipedia-org-9224 295 45 form form NN en-wikipedia-org-9224 295 46 of of IN en-wikipedia-org-9224 295 47 RNA RNA NNP en-wikipedia-org-9224 295 48 interference interference NN en-wikipedia-org-9224 295 49 . . . en-wikipedia-org-9224 296 1 [ [ -LRB- en-wikipedia-org-9224 296 2 151][152 151][152 CD en-wikipedia-org-9224 296 3 ] ] -RRB- en-wikipedia-org-9224 296 4 Prokaryotes Prokaryotes NNPS en-wikipedia-org-9224 296 5 also also RB en-wikipedia-org-9224 296 6 possess possess VBP en-wikipedia-org-9224 296 7 other other JJ en-wikipedia-org-9224 296 8 defense defense NN en-wikipedia-org-9224 296 9 mechanisms mechanism NNS en-wikipedia-org-9224 296 10 . . . en-wikipedia-org-9224 297 1 [ [ -LRB- en-wikipedia-org-9224 297 2 153][154 153][154 LS en-wikipedia-org-9224 297 3 ] ] -RRB- en-wikipedia-org-9224 297 4 Offensive offensive JJ en-wikipedia-org-9224 297 5 elements element NNS en-wikipedia-org-9224 297 6 of of IN en-wikipedia-org-9224 297 7 the the DT en-wikipedia-org-9224 297 8 immune immune JJ en-wikipedia-org-9224 297 9 systems system NNS en-wikipedia-org-9224 297 10 are be VBP en-wikipedia-org-9224 297 11 also also RB en-wikipedia-org-9224 297 12 present present JJ en-wikipedia-org-9224 297 13 in in IN en-wikipedia-org-9224 297 14 unicellular unicellular JJ en-wikipedia-org-9224 297 15 eukaryotes eukaryote NNS en-wikipedia-org-9224 297 16 , , , en-wikipedia-org-9224 297 17 but but CC en-wikipedia-org-9224 297 18 studies study NNS en-wikipedia-org-9224 297 19 of of IN en-wikipedia-org-9224 297 20 their -PRON- PRP$ en-wikipedia-org-9224 297 21 roles role NNS en-wikipedia-org-9224 297 22 in in IN en-wikipedia-org-9224 297 23 defense defense NN en-wikipedia-org-9224 297 24 are be VBP en-wikipedia-org-9224 297 25 few few JJ en-wikipedia-org-9224 297 26 . . . en-wikipedia-org-9224 298 1 [ [ -LRB- en-wikipedia-org-9224 298 2 155 155 CD en-wikipedia-org-9224 298 3 ] ] -RRB- en-wikipedia-org-9224 298 4 Pattern pattern NN en-wikipedia-org-9224 298 5 recognition recognition NN en-wikipedia-org-9224 298 6 receptors receptor NNS en-wikipedia-org-9224 298 7 are be VBP en-wikipedia-org-9224 298 8 proteins protein NNS en-wikipedia-org-9224 298 9 used use VBN en-wikipedia-org-9224 298 10 by by IN en-wikipedia-org-9224 298 11 nearly nearly RB en-wikipedia-org-9224 298 12 all all DT en-wikipedia-org-9224 298 13 organisms organism NNS en-wikipedia-org-9224 298 14 to to TO en-wikipedia-org-9224 298 15 identify identify VB en-wikipedia-org-9224 298 16 molecules molecule NNS en-wikipedia-org-9224 298 17 associated associate VBN en-wikipedia-org-9224 298 18 with with IN en-wikipedia-org-9224 298 19 pathogens pathogen NNS en-wikipedia-org-9224 298 20 . . . en-wikipedia-org-9224 299 1 Antimicrobial antimicrobial JJ en-wikipedia-org-9224 299 2 peptides peptide NNS en-wikipedia-org-9224 299 3 called call VBD en-wikipedia-org-9224 299 4 defensins defensin NNS en-wikipedia-org-9224 299 5 are be VBP en-wikipedia-org-9224 299 6 an an DT en-wikipedia-org-9224 299 7 evolutionarily evolutionarily RB en-wikipedia-org-9224 299 8 conserved conserve VBN en-wikipedia-org-9224 299 9 component component NN en-wikipedia-org-9224 299 10 of of IN en-wikipedia-org-9224 299 11 the the DT en-wikipedia-org-9224 299 12 innate innate JJ en-wikipedia-org-9224 299 13 immune immune JJ en-wikipedia-org-9224 299 14 response response NN en-wikipedia-org-9224 299 15 found find VBN en-wikipedia-org-9224 299 16 in in IN en-wikipedia-org-9224 299 17 all all DT en-wikipedia-org-9224 299 18 animals animal NNS en-wikipedia-org-9224 299 19 and and CC en-wikipedia-org-9224 299 20 plants plant NNS en-wikipedia-org-9224 299 21 , , , en-wikipedia-org-9224 299 22 and and CC en-wikipedia-org-9224 299 23 represent represent VB en-wikipedia-org-9224 299 24 the the DT en-wikipedia-org-9224 299 25 main main JJ en-wikipedia-org-9224 299 26 form form NN en-wikipedia-org-9224 299 27 of of IN en-wikipedia-org-9224 299 28 invertebrate invertebrate JJ en-wikipedia-org-9224 299 29 systemic systemic JJ en-wikipedia-org-9224 299 30 immunity immunity NN en-wikipedia-org-9224 299 31 . . . en-wikipedia-org-9224 300 1 [ [ -LRB- en-wikipedia-org-9224 300 2 149 149 CD en-wikipedia-org-9224 300 3 ] ] -RRB- en-wikipedia-org-9224 300 4 The the DT en-wikipedia-org-9224 300 5 complement complement NN en-wikipedia-org-9224 300 6 system system NN en-wikipedia-org-9224 300 7 and and CC en-wikipedia-org-9224 300 8 phagocytic phagocytic JJ en-wikipedia-org-9224 300 9 cells cell NNS en-wikipedia-org-9224 300 10 are be VBP en-wikipedia-org-9224 300 11 also also RB en-wikipedia-org-9224 300 12 used use VBN en-wikipedia-org-9224 300 13 by by IN en-wikipedia-org-9224 300 14 most most JJS en-wikipedia-org-9224 300 15 forms form NNS en-wikipedia-org-9224 300 16 of of IN en-wikipedia-org-9224 300 17 invertebrate invertebrate JJ en-wikipedia-org-9224 300 18 life life NN en-wikipedia-org-9224 300 19 . . . en-wikipedia-org-9224 301 1 Ribonucleases ribonuclease NNS en-wikipedia-org-9224 301 2 and and CC en-wikipedia-org-9224 301 3 the the DT en-wikipedia-org-9224 301 4 RNA RNA NNP en-wikipedia-org-9224 301 5 interference interference NN en-wikipedia-org-9224 301 6 pathway pathway NN en-wikipedia-org-9224 301 7 are be VBP en-wikipedia-org-9224 301 8 conserved conserve VBN en-wikipedia-org-9224 301 9 across across IN en-wikipedia-org-9224 301 10 all all DT en-wikipedia-org-9224 301 11 eukaryotes eukaryote NNS en-wikipedia-org-9224 301 12 , , , en-wikipedia-org-9224 301 13 and and CC en-wikipedia-org-9224 301 14 are be VBP en-wikipedia-org-9224 301 15 thought think VBN en-wikipedia-org-9224 301 16 to to TO en-wikipedia-org-9224 301 17 play play VB en-wikipedia-org-9224 301 18 a a DT en-wikipedia-org-9224 301 19 role role NN en-wikipedia-org-9224 301 20 in in IN en-wikipedia-org-9224 301 21 the the DT en-wikipedia-org-9224 301 22 immune immune JJ en-wikipedia-org-9224 301 23 response response NN en-wikipedia-org-9224 301 24 to to IN en-wikipedia-org-9224 301 25 viruses virus NNS en-wikipedia-org-9224 301 26 . . . en-wikipedia-org-9224 302 1 [ [ -LRB- en-wikipedia-org-9224 302 2 156 156 CD en-wikipedia-org-9224 302 3 ] ] -RRB- en-wikipedia-org-9224 302 4 Unlike unlike IN en-wikipedia-org-9224 302 5 animals animal NNS en-wikipedia-org-9224 302 6 , , , en-wikipedia-org-9224 302 7 plants plant NNS en-wikipedia-org-9224 302 8 lack lack VBP en-wikipedia-org-9224 302 9 phagocytic phagocytic JJ en-wikipedia-org-9224 302 10 cells cell NNS en-wikipedia-org-9224 302 11 , , , en-wikipedia-org-9224 302 12 but but CC en-wikipedia-org-9224 302 13 many many JJ en-wikipedia-org-9224 302 14 plant plant NN en-wikipedia-org-9224 302 15 immune immune JJ en-wikipedia-org-9224 302 16 responses response NNS en-wikipedia-org-9224 302 17 involve involve VBP en-wikipedia-org-9224 302 18 systemic systemic JJ en-wikipedia-org-9224 302 19 chemical chemical NN en-wikipedia-org-9224 302 20 signals signal NNS en-wikipedia-org-9224 302 21 that that WDT en-wikipedia-org-9224 302 22 are be VBP en-wikipedia-org-9224 302 23 sent send VBN en-wikipedia-org-9224 302 24 through through IN en-wikipedia-org-9224 302 25 a a DT en-wikipedia-org-9224 302 26 plant plant NN en-wikipedia-org-9224 302 27 . . . en-wikipedia-org-9224 303 1 [ [ -LRB- en-wikipedia-org-9224 303 2 157 157 CD en-wikipedia-org-9224 303 3 ] ] -RRB- en-wikipedia-org-9224 303 4 Individual individual JJ en-wikipedia-org-9224 303 5 plant plant NN en-wikipedia-org-9224 303 6 cells cell NNS en-wikipedia-org-9224 303 7 respond respond VBP en-wikipedia-org-9224 303 8 to to IN en-wikipedia-org-9224 303 9 molecules molecule NNS en-wikipedia-org-9224 303 10 associated associate VBN en-wikipedia-org-9224 303 11 with with IN en-wikipedia-org-9224 303 12 pathogens pathogen NNS en-wikipedia-org-9224 303 13 known know VBN en-wikipedia-org-9224 303 14 as as IN en-wikipedia-org-9224 303 15 pathogen pathogen NNP en-wikipedia-org-9224 303 16 - - HYPH en-wikipedia-org-9224 303 17 associated associate VBN en-wikipedia-org-9224 303 18 molecular molecular JJ en-wikipedia-org-9224 303 19 patterns pattern NNS en-wikipedia-org-9224 303 20 or or CC en-wikipedia-org-9224 303 21 PAMPs pamp NNS en-wikipedia-org-9224 303 22 . . . en-wikipedia-org-9224 304 1 [ [ -LRB- en-wikipedia-org-9224 304 2 158 158 CD en-wikipedia-org-9224 304 3 ] ] -RRB- en-wikipedia-org-9224 304 4 When when WRB en-wikipedia-org-9224 304 5 a a DT en-wikipedia-org-9224 304 6 part part NN en-wikipedia-org-9224 304 7 of of IN en-wikipedia-org-9224 304 8 a a DT en-wikipedia-org-9224 304 9 plant plant NN en-wikipedia-org-9224 304 10 becomes become VBZ en-wikipedia-org-9224 304 11 infected infect VBN en-wikipedia-org-9224 304 12 , , , en-wikipedia-org-9224 304 13 the the DT en-wikipedia-org-9224 304 14 plant plant NN en-wikipedia-org-9224 304 15 produces produce VBZ en-wikipedia-org-9224 304 16 a a DT en-wikipedia-org-9224 304 17 localized localized JJ en-wikipedia-org-9224 304 18 hypersensitive hypersensitive JJ en-wikipedia-org-9224 304 19 response response NN en-wikipedia-org-9224 304 20 , , , en-wikipedia-org-9224 304 21 whereby whereby WRB en-wikipedia-org-9224 304 22 cells cell NNS en-wikipedia-org-9224 304 23 at at IN en-wikipedia-org-9224 304 24 the the DT en-wikipedia-org-9224 304 25 site site NN en-wikipedia-org-9224 304 26 of of IN en-wikipedia-org-9224 304 27 infection infection NN en-wikipedia-org-9224 304 28 undergo undergo VBP en-wikipedia-org-9224 304 29 rapid rapid JJ en-wikipedia-org-9224 304 30 apoptosis apoptosis NN en-wikipedia-org-9224 304 31 to to TO en-wikipedia-org-9224 304 32 prevent prevent VB en-wikipedia-org-9224 304 33 the the DT en-wikipedia-org-9224 304 34 spread spread NN en-wikipedia-org-9224 304 35 of of IN en-wikipedia-org-9224 304 36 the the DT en-wikipedia-org-9224 304 37 disease disease NN en-wikipedia-org-9224 304 38 to to IN en-wikipedia-org-9224 304 39 other other JJ en-wikipedia-org-9224 304 40 parts part NNS en-wikipedia-org-9224 304 41 of of IN en-wikipedia-org-9224 304 42 the the DT en-wikipedia-org-9224 304 43 plant plant NN en-wikipedia-org-9224 304 44 . . . en-wikipedia-org-9224 305 1 Systemic systemic JJ en-wikipedia-org-9224 305 2 acquired acquire VBN en-wikipedia-org-9224 305 3 resistance resistance NN en-wikipedia-org-9224 305 4 is be VBZ en-wikipedia-org-9224 305 5 a a DT en-wikipedia-org-9224 305 6 type type NN en-wikipedia-org-9224 305 7 of of IN en-wikipedia-org-9224 305 8 defensive defensive JJ en-wikipedia-org-9224 305 9 response response NN en-wikipedia-org-9224 305 10 used use VBN en-wikipedia-org-9224 305 11 by by IN en-wikipedia-org-9224 305 12 plants plant NNS en-wikipedia-org-9224 305 13 that that WDT en-wikipedia-org-9224 305 14 renders render VBZ en-wikipedia-org-9224 305 15 the the DT en-wikipedia-org-9224 305 16 entire entire JJ en-wikipedia-org-9224 305 17 plant plant NN en-wikipedia-org-9224 305 18 resistant resistant JJ en-wikipedia-org-9224 305 19 to to IN en-wikipedia-org-9224 305 20 a a DT en-wikipedia-org-9224 305 21 particular particular JJ en-wikipedia-org-9224 305 22 infectious infectious JJ en-wikipedia-org-9224 305 23 agent agent NN en-wikipedia-org-9224 305 24 . . . en-wikipedia-org-9224 306 1 [ [ -LRB- en-wikipedia-org-9224 306 2 157 157 CD en-wikipedia-org-9224 306 3 ] ] -RRB- en-wikipedia-org-9224 306 4 RNA RNA NNP en-wikipedia-org-9224 306 5 silencing silencing NN en-wikipedia-org-9224 306 6 mechanisms mechanism NNS en-wikipedia-org-9224 306 7 are be VBP en-wikipedia-org-9224 306 8 particularly particularly RB en-wikipedia-org-9224 306 9 important important JJ en-wikipedia-org-9224 306 10 in in IN en-wikipedia-org-9224 306 11 this this DT en-wikipedia-org-9224 306 12 systemic systemic JJ en-wikipedia-org-9224 306 13 response response NN en-wikipedia-org-9224 306 14 as as IN en-wikipedia-org-9224 306 15 they -PRON- PRP en-wikipedia-org-9224 306 16 can can MD en-wikipedia-org-9224 306 17 block block VB en-wikipedia-org-9224 306 18 virus virus NN en-wikipedia-org-9224 306 19 replication replication NN en-wikipedia-org-9224 306 20 . . . en-wikipedia-org-9224 307 1 [ [ -LRB- en-wikipedia-org-9224 307 2 159 159 CD en-wikipedia-org-9224 307 3 ] ] -RRB- en-wikipedia-org-9224 307 4 Alternative alternative JJ en-wikipedia-org-9224 307 5 adaptive adaptive JJ en-wikipedia-org-9224 307 6 immune immune NN en-wikipedia-org-9224 307 7 system[edit system[edit . en-wikipedia-org-9224 307 8 ] ] -RRB- en-wikipedia-org-9224 307 9 Evolution evolution NN en-wikipedia-org-9224 307 10 of of IN en-wikipedia-org-9224 307 11 the the DT en-wikipedia-org-9224 307 12 adaptive adaptive JJ en-wikipedia-org-9224 307 13 immune immune JJ en-wikipedia-org-9224 307 14 system system NN en-wikipedia-org-9224 307 15 occurred occur VBD en-wikipedia-org-9224 307 16 in in IN en-wikipedia-org-9224 307 17 an an DT en-wikipedia-org-9224 307 18 ancestor ancestor NN en-wikipedia-org-9224 307 19 of of IN en-wikipedia-org-9224 307 20 the the DT en-wikipedia-org-9224 307 21 jawed jawed JJ en-wikipedia-org-9224 307 22 vertebrates vertebrate NNS en-wikipedia-org-9224 307 23 . . . en-wikipedia-org-9224 308 1 Many many JJ en-wikipedia-org-9224 308 2 of of IN en-wikipedia-org-9224 308 3 the the DT en-wikipedia-org-9224 308 4 classical classical JJ en-wikipedia-org-9224 308 5 molecules molecule NNS en-wikipedia-org-9224 308 6 of of IN en-wikipedia-org-9224 308 7 the the DT en-wikipedia-org-9224 308 8 adaptive adaptive JJ en-wikipedia-org-9224 308 9 immune immune JJ en-wikipedia-org-9224 308 10 system system NN en-wikipedia-org-9224 308 11 ( ( -LRB- en-wikipedia-org-9224 308 12 for for IN en-wikipedia-org-9224 308 13 example example NN en-wikipedia-org-9224 308 14 , , , en-wikipedia-org-9224 308 15 immunoglobulins immunoglobulin NNS en-wikipedia-org-9224 308 16 and and CC en-wikipedia-org-9224 308 17 T t NN en-wikipedia-org-9224 308 18 - - HYPH en-wikipedia-org-9224 308 19 cell cell NN en-wikipedia-org-9224 308 20 receptors receptor NNS en-wikipedia-org-9224 308 21 ) ) -RRB- en-wikipedia-org-9224 308 22 exist exist VBP en-wikipedia-org-9224 308 23 only only RB en-wikipedia-org-9224 308 24 in in IN en-wikipedia-org-9224 308 25 jawed jawed JJ en-wikipedia-org-9224 308 26 vertebrates vertebrate NNS en-wikipedia-org-9224 308 27 . . . en-wikipedia-org-9224 309 1 A a DT en-wikipedia-org-9224 309 2 distinct distinct JJ en-wikipedia-org-9224 309 3 lymphocyte lymphocyte NN en-wikipedia-org-9224 309 4 - - HYPH en-wikipedia-org-9224 309 5 derived derive VBN en-wikipedia-org-9224 309 6 molecule molecule NN en-wikipedia-org-9224 309 7 has have VBZ en-wikipedia-org-9224 309 8 been be VBN en-wikipedia-org-9224 309 9 discovered discover VBN en-wikipedia-org-9224 309 10 in in IN en-wikipedia-org-9224 309 11 primitive primitive JJ en-wikipedia-org-9224 309 12 jawless jawless NN en-wikipedia-org-9224 309 13 vertebrates vertebrate NNS en-wikipedia-org-9224 309 14 , , , en-wikipedia-org-9224 309 15 such such JJ en-wikipedia-org-9224 309 16 as as IN en-wikipedia-org-9224 309 17 the the DT en-wikipedia-org-9224 309 18 lamprey lamprey NNP en-wikipedia-org-9224 309 19 and and CC en-wikipedia-org-9224 309 20 hagfish hagfish JJ en-wikipedia-org-9224 309 21 . . . en-wikipedia-org-9224 310 1 These these DT en-wikipedia-org-9224 310 2 animals animal NNS en-wikipedia-org-9224 310 3 possess possess VBP en-wikipedia-org-9224 310 4 a a DT en-wikipedia-org-9224 310 5 large large JJ en-wikipedia-org-9224 310 6 array array NN en-wikipedia-org-9224 310 7 of of IN en-wikipedia-org-9224 310 8 molecules molecule NNS en-wikipedia-org-9224 310 9 called call VBN en-wikipedia-org-9224 310 10 Variable Variable NNP en-wikipedia-org-9224 310 11 lymphocyte lymphocyte NN en-wikipedia-org-9224 310 12 receptors receptor NNS en-wikipedia-org-9224 310 13 ( ( -LRB- en-wikipedia-org-9224 310 14 VLRs VLRs NNP en-wikipedia-org-9224 310 15 ) ) -RRB- en-wikipedia-org-9224 310 16 that that IN en-wikipedia-org-9224 310 17 , , , en-wikipedia-org-9224 310 18 like like IN en-wikipedia-org-9224 310 19 the the DT en-wikipedia-org-9224 310 20 antigen antigen NN en-wikipedia-org-9224 310 21 receptors receptor NNS en-wikipedia-org-9224 310 22 of of IN en-wikipedia-org-9224 310 23 jawed jawed JJ en-wikipedia-org-9224 310 24 vertebrates vertebrate NNS en-wikipedia-org-9224 310 25 , , , en-wikipedia-org-9224 310 26 are be VBP en-wikipedia-org-9224 310 27 produced produce VBN en-wikipedia-org-9224 310 28 from from IN en-wikipedia-org-9224 310 29 only only RB en-wikipedia-org-9224 310 30 a a DT en-wikipedia-org-9224 310 31 small small JJ en-wikipedia-org-9224 310 32 number number NN en-wikipedia-org-9224 310 33 ( ( -LRB- en-wikipedia-org-9224 310 34 one one CD en-wikipedia-org-9224 310 35 or or CC en-wikipedia-org-9224 310 36 two two CD en-wikipedia-org-9224 310 37 ) ) -RRB- en-wikipedia-org-9224 310 38 of of IN en-wikipedia-org-9224 310 39 genes gene NNS en-wikipedia-org-9224 310 40 . . . en-wikipedia-org-9224 311 1 These these DT en-wikipedia-org-9224 311 2 molecules molecule NNS en-wikipedia-org-9224 311 3 are be VBP en-wikipedia-org-9224 311 4 believed believe VBN en-wikipedia-org-9224 311 5 to to TO en-wikipedia-org-9224 311 6 bind bind VB en-wikipedia-org-9224 311 7 pathogenic pathogenic JJ en-wikipedia-org-9224 311 8 antigens antigen NNS en-wikipedia-org-9224 311 9 in in IN en-wikipedia-org-9224 311 10 a a DT en-wikipedia-org-9224 311 11 similar similar JJ en-wikipedia-org-9224 311 12 way way NN en-wikipedia-org-9224 311 13 to to IN en-wikipedia-org-9224 311 14 antibodies antibody NNS en-wikipedia-org-9224 311 15 , , , en-wikipedia-org-9224 311 16 and and CC en-wikipedia-org-9224 311 17 with with IN en-wikipedia-org-9224 311 18 the the DT en-wikipedia-org-9224 311 19 same same JJ en-wikipedia-org-9224 311 20 degree degree NN en-wikipedia-org-9224 311 21 of of IN en-wikipedia-org-9224 311 22 specificity specificity NN en-wikipedia-org-9224 311 23 . . . en-wikipedia-org-9224 312 1 [ [ -LRB- en-wikipedia-org-9224 312 2 160 160 CD en-wikipedia-org-9224 312 3 ] ] -RRB- en-wikipedia-org-9224 312 4 Manipulation manipulation NN en-wikipedia-org-9224 312 5 by by IN en-wikipedia-org-9224 312 6 pathogens[edit pathogens[edit LS en-wikipedia-org-9224 312 7 ] ] -RRB- en-wikipedia-org-9224 312 8 The the DT en-wikipedia-org-9224 312 9 success success NN en-wikipedia-org-9224 312 10 of of IN en-wikipedia-org-9224 312 11 any any DT en-wikipedia-org-9224 312 12 pathogen pathogen NN en-wikipedia-org-9224 312 13 depends depend VBZ en-wikipedia-org-9224 312 14 on on IN en-wikipedia-org-9224 312 15 its -PRON- PRP$ en-wikipedia-org-9224 312 16 ability ability NN en-wikipedia-org-9224 312 17 to to TO en-wikipedia-org-9224 312 18 elude elude VB en-wikipedia-org-9224 312 19 host host NN en-wikipedia-org-9224 312 20 immune immune JJ en-wikipedia-org-9224 312 21 responses response NNS en-wikipedia-org-9224 312 22 . . . en-wikipedia-org-9224 313 1 Therefore therefore RB en-wikipedia-org-9224 313 2 , , , en-wikipedia-org-9224 313 3 pathogens pathogens NNP en-wikipedia-org-9224 313 4 evolved evolve VBD en-wikipedia-org-9224 313 5 several several JJ en-wikipedia-org-9224 313 6 methods method NNS en-wikipedia-org-9224 313 7 that that WDT en-wikipedia-org-9224 313 8 allow allow VBP en-wikipedia-org-9224 313 9 them -PRON- PRP en-wikipedia-org-9224 313 10 to to TO en-wikipedia-org-9224 313 11 successfully successfully RB en-wikipedia-org-9224 313 12 infect infect VB en-wikipedia-org-9224 313 13 a a DT en-wikipedia-org-9224 313 14 host host NN en-wikipedia-org-9224 313 15 , , , en-wikipedia-org-9224 313 16 while while IN en-wikipedia-org-9224 313 17 evading evade VBG en-wikipedia-org-9224 313 18 detection detection NN en-wikipedia-org-9224 313 19 or or CC en-wikipedia-org-9224 313 20 destruction destruction NN en-wikipedia-org-9224 313 21 by by IN en-wikipedia-org-9224 313 22 the the DT en-wikipedia-org-9224 313 23 immune immune JJ en-wikipedia-org-9224 313 24 system system NN en-wikipedia-org-9224 313 25 . . . en-wikipedia-org-9224 314 1 [ [ -LRB- en-wikipedia-org-9224 314 2 161 161 CD en-wikipedia-org-9224 314 3 ] ] -RRB- en-wikipedia-org-9224 314 4 Bacteria Bacteria NNS en-wikipedia-org-9224 314 5 often often RB en-wikipedia-org-9224 314 6 overcome overcome VBP en-wikipedia-org-9224 314 7 physical physical JJ en-wikipedia-org-9224 314 8 barriers barrier NNS en-wikipedia-org-9224 314 9 by by IN en-wikipedia-org-9224 314 10 secreting secrete VBG en-wikipedia-org-9224 314 11 enzymes enzyme NNS en-wikipedia-org-9224 314 12 that that WDT en-wikipedia-org-9224 314 13 digest digest VBP en-wikipedia-org-9224 314 14 the the DT en-wikipedia-org-9224 314 15 barrier barrier NN en-wikipedia-org-9224 314 16 , , , en-wikipedia-org-9224 314 17 for for IN en-wikipedia-org-9224 314 18 example example NN en-wikipedia-org-9224 314 19 , , , en-wikipedia-org-9224 314 20 by by IN en-wikipedia-org-9224 314 21 using use VBG en-wikipedia-org-9224 314 22 a a DT en-wikipedia-org-9224 314 23 type type NN en-wikipedia-org-9224 314 24 II II NNP en-wikipedia-org-9224 314 25 secretion secretion NN en-wikipedia-org-9224 314 26 system system NN en-wikipedia-org-9224 314 27 . . . en-wikipedia-org-9224 315 1 [ [ -LRB- en-wikipedia-org-9224 315 2 162 162 CD en-wikipedia-org-9224 315 3 ] ] -RRB- en-wikipedia-org-9224 315 4 Alternatively alternatively RB en-wikipedia-org-9224 315 5 , , , en-wikipedia-org-9224 315 6 using use VBG en-wikipedia-org-9224 315 7 a a DT en-wikipedia-org-9224 315 8 type type NN en-wikipedia-org-9224 315 9 III iii CD en-wikipedia-org-9224 315 10 secretion secretion NN en-wikipedia-org-9224 315 11 system system NN en-wikipedia-org-9224 315 12 , , , en-wikipedia-org-9224 315 13 they -PRON- PRP en-wikipedia-org-9224 315 14 may may MD en-wikipedia-org-9224 315 15 insert insert VB en-wikipedia-org-9224 315 16 a a DT en-wikipedia-org-9224 315 17 hollow hollow JJ en-wikipedia-org-9224 315 18 tube tube NN en-wikipedia-org-9224 315 19 into into IN en-wikipedia-org-9224 315 20 the the DT en-wikipedia-org-9224 315 21 host host NN en-wikipedia-org-9224 315 22 cell cell NN en-wikipedia-org-9224 315 23 , , , en-wikipedia-org-9224 315 24 providing provide VBG en-wikipedia-org-9224 315 25 a a DT en-wikipedia-org-9224 315 26 direct direct JJ en-wikipedia-org-9224 315 27 route route NN en-wikipedia-org-9224 315 28 for for IN en-wikipedia-org-9224 315 29 proteins protein NNS en-wikipedia-org-9224 315 30 to to TO en-wikipedia-org-9224 315 31 move move VB en-wikipedia-org-9224 315 32 from from IN en-wikipedia-org-9224 315 33 the the DT en-wikipedia-org-9224 315 34 pathogen pathogen NN en-wikipedia-org-9224 315 35 to to IN en-wikipedia-org-9224 315 36 the the DT en-wikipedia-org-9224 315 37 host host NN en-wikipedia-org-9224 315 38 . . . en-wikipedia-org-9224 316 1 These these DT en-wikipedia-org-9224 316 2 proteins protein NNS en-wikipedia-org-9224 316 3 are be VBP en-wikipedia-org-9224 316 4 often often RB en-wikipedia-org-9224 316 5 used use VBN en-wikipedia-org-9224 316 6 to to TO en-wikipedia-org-9224 316 7 shut shut VB en-wikipedia-org-9224 316 8 down down RP en-wikipedia-org-9224 316 9 host host NN en-wikipedia-org-9224 316 10 defenses defense NNS en-wikipedia-org-9224 316 11 . . . en-wikipedia-org-9224 317 1 [ [ -LRB- en-wikipedia-org-9224 317 2 163 163 CD en-wikipedia-org-9224 317 3 ] ] -RRB- en-wikipedia-org-9224 317 4 An an DT en-wikipedia-org-9224 317 5 evasion evasion NN en-wikipedia-org-9224 317 6 strategy strategy NN en-wikipedia-org-9224 317 7 used use VBN en-wikipedia-org-9224 317 8 by by IN en-wikipedia-org-9224 317 9 several several JJ en-wikipedia-org-9224 317 10 pathogens pathogen NNS en-wikipedia-org-9224 317 11 to to TO en-wikipedia-org-9224 317 12 avoid avoid VB en-wikipedia-org-9224 317 13 the the DT en-wikipedia-org-9224 317 14 innate innate JJ en-wikipedia-org-9224 317 15 immune immune JJ en-wikipedia-org-9224 317 16 system system NN en-wikipedia-org-9224 317 17 is be VBZ en-wikipedia-org-9224 317 18 to to TO en-wikipedia-org-9224 317 19 hide hide VB en-wikipedia-org-9224 317 20 within within IN en-wikipedia-org-9224 317 21 the the DT en-wikipedia-org-9224 317 22 cells cell NNS en-wikipedia-org-9224 317 23 of of IN en-wikipedia-org-9224 317 24 their -PRON- PRP$ en-wikipedia-org-9224 317 25 host host NN en-wikipedia-org-9224 317 26 ( ( -LRB- en-wikipedia-org-9224 317 27 also also RB en-wikipedia-org-9224 317 28 called call VBN en-wikipedia-org-9224 317 29 intracellular intracellular JJ en-wikipedia-org-9224 317 30 pathogenesis pathogenesis NN en-wikipedia-org-9224 317 31 ) ) -RRB- en-wikipedia-org-9224 317 32 . . . en-wikipedia-org-9224 318 1 Here here RB en-wikipedia-org-9224 318 2 , , , en-wikipedia-org-9224 318 3 a a DT en-wikipedia-org-9224 318 4 pathogen pathogen NN en-wikipedia-org-9224 318 5 spends spend VBZ en-wikipedia-org-9224 318 6 most most JJS en-wikipedia-org-9224 318 7 of of IN en-wikipedia-org-9224 318 8 its -PRON- PRP$ en-wikipedia-org-9224 318 9 life life NN en-wikipedia-org-9224 318 10 - - HYPH en-wikipedia-org-9224 318 11 cycle cycle NN en-wikipedia-org-9224 318 12 inside inside IN en-wikipedia-org-9224 318 13 host host NN en-wikipedia-org-9224 318 14 cells cell NNS en-wikipedia-org-9224 318 15 , , , en-wikipedia-org-9224 318 16 where where WRB en-wikipedia-org-9224 318 17 it -PRON- PRP en-wikipedia-org-9224 318 18 is be VBZ en-wikipedia-org-9224 318 19 shielded shield VBN en-wikipedia-org-9224 318 20 from from IN en-wikipedia-org-9224 318 21 direct direct JJ en-wikipedia-org-9224 318 22 contact contact NN en-wikipedia-org-9224 318 23 with with IN en-wikipedia-org-9224 318 24 immune immune JJ en-wikipedia-org-9224 318 25 cells cell NNS en-wikipedia-org-9224 318 26 , , , en-wikipedia-org-9224 318 27 antibodies antibody NNS en-wikipedia-org-9224 318 28 and and CC en-wikipedia-org-9224 318 29 complement complement NN en-wikipedia-org-9224 318 30 . . . en-wikipedia-org-9224 319 1 Some some DT en-wikipedia-org-9224 319 2 examples example NNS en-wikipedia-org-9224 319 3 of of IN en-wikipedia-org-9224 319 4 intracellular intracellular JJ en-wikipedia-org-9224 319 5 pathogens pathogen NNS en-wikipedia-org-9224 319 6 include include VBP en-wikipedia-org-9224 319 7 viruses virus NNS en-wikipedia-org-9224 319 8 , , , en-wikipedia-org-9224 319 9 the the DT en-wikipedia-org-9224 319 10 food food NN en-wikipedia-org-9224 319 11 poisoning poisoning NN en-wikipedia-org-9224 319 12 bacterium bacterium NN en-wikipedia-org-9224 319 13 Salmonella Salmonella NNP en-wikipedia-org-9224 319 14 and and CC en-wikipedia-org-9224 319 15 the the DT en-wikipedia-org-9224 319 16 eukaryotic eukaryotic JJ en-wikipedia-org-9224 319 17 parasites parasite NNS en-wikipedia-org-9224 319 18 that that WDT en-wikipedia-org-9224 319 19 cause cause VBP en-wikipedia-org-9224 319 20 malaria malaria NN en-wikipedia-org-9224 319 21 ( ( -LRB- en-wikipedia-org-9224 319 22 Plasmodium Plasmodium NNP en-wikipedia-org-9224 319 23 spp spp NN en-wikipedia-org-9224 319 24 . . . en-wikipedia-org-9224 319 25 ) ) -RRB- en-wikipedia-org-9224 320 1 and and CC en-wikipedia-org-9224 320 2 leishmaniasis leishmaniasis NNP en-wikipedia-org-9224 320 3 ( ( -LRB- en-wikipedia-org-9224 320 4 Leishmania Leishmania NNP en-wikipedia-org-9224 320 5 spp spp NN en-wikipedia-org-9224 320 6 . . . en-wikipedia-org-9224 320 7 ) ) -RRB- en-wikipedia-org-9224 320 8 . . . en-wikipedia-org-9224 321 1 Other other JJ en-wikipedia-org-9224 321 2 bacteria bacteria NNS en-wikipedia-org-9224 321 3 , , , en-wikipedia-org-9224 321 4 such such JJ en-wikipedia-org-9224 321 5 as as IN en-wikipedia-org-9224 321 6 Mycobacterium mycobacterium JJ en-wikipedia-org-9224 321 7 tuberculosis tuberculosis NN en-wikipedia-org-9224 321 8 , , , en-wikipedia-org-9224 321 9 live live VBP en-wikipedia-org-9224 321 10 inside inside IN en-wikipedia-org-9224 321 11 a a DT en-wikipedia-org-9224 321 12 protective protective JJ en-wikipedia-org-9224 321 13 capsule capsule NN en-wikipedia-org-9224 321 14 that that WDT en-wikipedia-org-9224 321 15 prevents prevent VBZ en-wikipedia-org-9224 321 16 lysis lysis NN en-wikipedia-org-9224 321 17 by by IN en-wikipedia-org-9224 321 18 complement complement NN en-wikipedia-org-9224 321 19 . . . en-wikipedia-org-9224 322 1 [ [ -LRB- en-wikipedia-org-9224 322 2 164 164 CD en-wikipedia-org-9224 322 3 ] ] -RRB- en-wikipedia-org-9224 322 4 Many many JJ en-wikipedia-org-9224 322 5 pathogens pathogen VBZ en-wikipedia-org-9224 322 6 secrete secrete JJ en-wikipedia-org-9224 322 7 compounds compound NNS en-wikipedia-org-9224 322 8 that that WDT en-wikipedia-org-9224 322 9 diminish diminish VBP en-wikipedia-org-9224 322 10 or or CC en-wikipedia-org-9224 322 11 misdirect misdirect VBP en-wikipedia-org-9224 322 12 the the DT en-wikipedia-org-9224 322 13 host host NN en-wikipedia-org-9224 322 14 's 's POS en-wikipedia-org-9224 322 15 immune immune JJ en-wikipedia-org-9224 322 16 response response NN en-wikipedia-org-9224 322 17 . . . en-wikipedia-org-9224 323 1 [ [ -LRB- en-wikipedia-org-9224 323 2 161 161 CD en-wikipedia-org-9224 323 3 ] ] -RRB- en-wikipedia-org-9224 323 4 Some some DT en-wikipedia-org-9224 323 5 bacteria bacteria NNS en-wikipedia-org-9224 323 6 form form VBP en-wikipedia-org-9224 323 7 biofilms biofilm NNS en-wikipedia-org-9224 323 8 to to TO en-wikipedia-org-9224 323 9 protect protect VB en-wikipedia-org-9224 323 10 themselves -PRON- PRP en-wikipedia-org-9224 323 11 from from IN en-wikipedia-org-9224 323 12 the the DT en-wikipedia-org-9224 323 13 cells cell NNS en-wikipedia-org-9224 323 14 and and CC en-wikipedia-org-9224 323 15 proteins protein NNS en-wikipedia-org-9224 323 16 of of IN en-wikipedia-org-9224 323 17 the the DT en-wikipedia-org-9224 323 18 immune immune JJ en-wikipedia-org-9224 323 19 system system NN en-wikipedia-org-9224 323 20 . . . en-wikipedia-org-9224 324 1 Such such JJ en-wikipedia-org-9224 324 2 biofilms biofilm NNS en-wikipedia-org-9224 324 3 are be VBP en-wikipedia-org-9224 324 4 present present JJ en-wikipedia-org-9224 324 5 in in IN en-wikipedia-org-9224 324 6 many many JJ en-wikipedia-org-9224 324 7 successful successful JJ en-wikipedia-org-9224 324 8 infections infection NNS en-wikipedia-org-9224 324 9 , , , en-wikipedia-org-9224 324 10 such such JJ en-wikipedia-org-9224 324 11 as as IN en-wikipedia-org-9224 324 12 the the DT en-wikipedia-org-9224 324 13 chronic chronic JJ en-wikipedia-org-9224 324 14 Pseudomonas Pseudomonas NNP en-wikipedia-org-9224 324 15 aeruginosa aeruginosa NNP en-wikipedia-org-9224 324 16 and and CC en-wikipedia-org-9224 324 17 Burkholderia Burkholderia NNP en-wikipedia-org-9224 324 18 cenocepacia cenocepacia NN en-wikipedia-org-9224 324 19 infections infection NNS en-wikipedia-org-9224 324 20 characteristic characteristic JJ en-wikipedia-org-9224 324 21 of of IN en-wikipedia-org-9224 324 22 cystic cystic JJ en-wikipedia-org-9224 324 23 fibrosis fibrosis NN en-wikipedia-org-9224 324 24 . . . en-wikipedia-org-9224 325 1 [ [ -LRB- en-wikipedia-org-9224 325 2 165 165 CD en-wikipedia-org-9224 325 3 ] ] -RRB- en-wikipedia-org-9224 325 4 Other other JJ en-wikipedia-org-9224 325 5 bacteria bacteria NNS en-wikipedia-org-9224 325 6 generate generate VBP en-wikipedia-org-9224 325 7 surface surface NN en-wikipedia-org-9224 325 8 proteins protein NNS en-wikipedia-org-9224 325 9 that that WDT en-wikipedia-org-9224 325 10 bind bind VBP en-wikipedia-org-9224 325 11 to to IN en-wikipedia-org-9224 325 12 antibodies antibody NNS en-wikipedia-org-9224 325 13 , , , en-wikipedia-org-9224 325 14 rendering render VBG en-wikipedia-org-9224 325 15 them -PRON- PRP en-wikipedia-org-9224 325 16 ineffective ineffective JJ en-wikipedia-org-9224 325 17 ; ; : en-wikipedia-org-9224 325 18 examples example NNS en-wikipedia-org-9224 325 19 include include VBP en-wikipedia-org-9224 325 20 Streptococcus Streptococcus NNP en-wikipedia-org-9224 325 21 ( ( -LRB- en-wikipedia-org-9224 325 22 protein protein NN en-wikipedia-org-9224 325 23 G g NN en-wikipedia-org-9224 325 24 ) ) -RRB- en-wikipedia-org-9224 325 25 , , , en-wikipedia-org-9224 325 26 Staphylococcus Staphylococcus NNP en-wikipedia-org-9224 325 27 aureus aureus NNP en-wikipedia-org-9224 325 28 ( ( -LRB- en-wikipedia-org-9224 325 29 protein protein NN en-wikipedia-org-9224 325 30 A a NN en-wikipedia-org-9224 325 31 ) ) -RRB- en-wikipedia-org-9224 325 32 , , , en-wikipedia-org-9224 325 33 and and CC en-wikipedia-org-9224 325 34 Peptostreptococcus Peptostreptococcus NNP en-wikipedia-org-9224 325 35 magnus magnus NN en-wikipedia-org-9224 325 36 ( ( -LRB- en-wikipedia-org-9224 325 37 protein protein NN en-wikipedia-org-9224 325 38 L L NNP en-wikipedia-org-9224 325 39 ) ) -RRB- en-wikipedia-org-9224 325 40 . . . en-wikipedia-org-9224 326 1 [ [ -LRB- en-wikipedia-org-9224 326 2 166 166 CD en-wikipedia-org-9224 326 3 ] ] -RRB- en-wikipedia-org-9224 326 4 The the DT en-wikipedia-org-9224 326 5 mechanisms mechanism NNS en-wikipedia-org-9224 326 6 used use VBD en-wikipedia-org-9224 326 7 to to TO en-wikipedia-org-9224 326 8 evade evade VB en-wikipedia-org-9224 326 9 the the DT en-wikipedia-org-9224 326 10 adaptive adaptive JJ en-wikipedia-org-9224 326 11 immune immune JJ en-wikipedia-org-9224 326 12 system system NN en-wikipedia-org-9224 326 13 are be VBP en-wikipedia-org-9224 326 14 more more RBR en-wikipedia-org-9224 326 15 complicated complicated JJ en-wikipedia-org-9224 326 16 . . . en-wikipedia-org-9224 327 1 The the DT en-wikipedia-org-9224 327 2 simplest simple JJS en-wikipedia-org-9224 327 3 approach approach NN en-wikipedia-org-9224 327 4 is be VBZ en-wikipedia-org-9224 327 5 to to TO en-wikipedia-org-9224 327 6 rapidly rapidly RB en-wikipedia-org-9224 327 7 change change VB en-wikipedia-org-9224 327 8 non non JJ en-wikipedia-org-9224 327 9 - - JJ en-wikipedia-org-9224 327 10 essential essential JJ en-wikipedia-org-9224 327 11 epitopes epitope NNS en-wikipedia-org-9224 327 12 ( ( -LRB- en-wikipedia-org-9224 327 13 amino amino JJ en-wikipedia-org-9224 327 14 acids acid NNS en-wikipedia-org-9224 327 15 and/or and/or CC en-wikipedia-org-9224 327 16 sugars sugar VBZ en-wikipedia-org-9224 327 17 ) ) -RRB- en-wikipedia-org-9224 327 18 on on IN en-wikipedia-org-9224 327 19 the the DT en-wikipedia-org-9224 327 20 surface surface NN en-wikipedia-org-9224 327 21 of of IN en-wikipedia-org-9224 327 22 the the DT en-wikipedia-org-9224 327 23 pathogen pathogen NN en-wikipedia-org-9224 327 24 , , , en-wikipedia-org-9224 327 25 while while IN en-wikipedia-org-9224 327 26 keeping keep VBG en-wikipedia-org-9224 327 27 essential essential JJ en-wikipedia-org-9224 327 28 epitopes epitope NNS en-wikipedia-org-9224 327 29 concealed conceal VBD en-wikipedia-org-9224 327 30 . . . en-wikipedia-org-9224 328 1 This this DT en-wikipedia-org-9224 328 2 is be VBZ en-wikipedia-org-9224 328 3 called call VBN en-wikipedia-org-9224 328 4 antigenic antigenic JJ en-wikipedia-org-9224 328 5 variation variation NN en-wikipedia-org-9224 328 6 . . . en-wikipedia-org-9224 329 1 An an DT en-wikipedia-org-9224 329 2 example example NN en-wikipedia-org-9224 329 3 is be VBZ en-wikipedia-org-9224 329 4 HIV HIV NNP en-wikipedia-org-9224 329 5 , , , en-wikipedia-org-9224 329 6 which which WDT en-wikipedia-org-9224 329 7 mutates mutate VBZ en-wikipedia-org-9224 329 8 rapidly rapidly RB en-wikipedia-org-9224 329 9 , , , en-wikipedia-org-9224 329 10 so so RB en-wikipedia-org-9224 329 11 the the DT en-wikipedia-org-9224 329 12 proteins protein NNS en-wikipedia-org-9224 329 13 on on IN en-wikipedia-org-9224 329 14 its -PRON- PRP$ en-wikipedia-org-9224 329 15 viral viral JJ en-wikipedia-org-9224 329 16 envelope envelope NN en-wikipedia-org-9224 329 17 that that WDT en-wikipedia-org-9224 329 18 are be VBP en-wikipedia-org-9224 329 19 essential essential JJ en-wikipedia-org-9224 329 20 for for IN en-wikipedia-org-9224 329 21 entry entry NN en-wikipedia-org-9224 329 22 into into IN en-wikipedia-org-9224 329 23 its -PRON- PRP$ en-wikipedia-org-9224 329 24 host host NN en-wikipedia-org-9224 329 25 target target NN en-wikipedia-org-9224 329 26 cell cell NN en-wikipedia-org-9224 329 27 are be VBP en-wikipedia-org-9224 329 28 constantly constantly RB en-wikipedia-org-9224 329 29 changing change VBG en-wikipedia-org-9224 329 30 . . . en-wikipedia-org-9224 330 1 These these DT en-wikipedia-org-9224 330 2 frequent frequent JJ en-wikipedia-org-9224 330 3 changes change NNS en-wikipedia-org-9224 330 4 in in IN en-wikipedia-org-9224 330 5 antigens antigen NNS en-wikipedia-org-9224 330 6 may may MD en-wikipedia-org-9224 330 7 explain explain VB en-wikipedia-org-9224 330 8 the the DT en-wikipedia-org-9224 330 9 failures failure NNS en-wikipedia-org-9224 330 10 of of IN en-wikipedia-org-9224 330 11 vaccines vaccine NNS en-wikipedia-org-9224 330 12 directed direct VBN en-wikipedia-org-9224 330 13 at at IN en-wikipedia-org-9224 330 14 this this DT en-wikipedia-org-9224 330 15 virus virus NN en-wikipedia-org-9224 330 16 . . . en-wikipedia-org-9224 331 1 [ [ -LRB- en-wikipedia-org-9224 331 2 167 167 CD en-wikipedia-org-9224 331 3 ] ] -RRB- en-wikipedia-org-9224 331 4 The the DT en-wikipedia-org-9224 331 5 parasite parasite NN en-wikipedia-org-9224 331 6 Trypanosoma Trypanosoma NNP en-wikipedia-org-9224 331 7 brucei brucei NN en-wikipedia-org-9224 331 8 uses use VBZ en-wikipedia-org-9224 331 9 a a DT en-wikipedia-org-9224 331 10 similar similar JJ en-wikipedia-org-9224 331 11 strategy strategy NN en-wikipedia-org-9224 331 12 , , , en-wikipedia-org-9224 331 13 constantly constantly RB en-wikipedia-org-9224 331 14 switching switch VBG en-wikipedia-org-9224 331 15 one one CD en-wikipedia-org-9224 331 16 type type NN en-wikipedia-org-9224 331 17 of of IN en-wikipedia-org-9224 331 18 surface surface NN en-wikipedia-org-9224 331 19 protein protein NN en-wikipedia-org-9224 331 20 for for IN en-wikipedia-org-9224 331 21 another another DT en-wikipedia-org-9224 331 22 , , , en-wikipedia-org-9224 331 23 allowing allow VBG en-wikipedia-org-9224 331 24 it -PRON- PRP en-wikipedia-org-9224 331 25 to to TO en-wikipedia-org-9224 331 26 stay stay VB en-wikipedia-org-9224 331 27 one one CD en-wikipedia-org-9224 331 28 step step NN en-wikipedia-org-9224 331 29 ahead ahead RB en-wikipedia-org-9224 331 30 of of IN en-wikipedia-org-9224 331 31 the the DT en-wikipedia-org-9224 331 32 antibody antibody NN en-wikipedia-org-9224 331 33 response response NN en-wikipedia-org-9224 331 34 . . . en-wikipedia-org-9224 332 1 [ [ -LRB- en-wikipedia-org-9224 332 2 168 168 CD en-wikipedia-org-9224 332 3 ] ] -RRB- en-wikipedia-org-9224 332 4 Masking mask VBG en-wikipedia-org-9224 332 5 antigens antigen NNS en-wikipedia-org-9224 332 6 with with IN en-wikipedia-org-9224 332 7 host host NN en-wikipedia-org-9224 332 8 molecules molecule NNS en-wikipedia-org-9224 332 9 is be VBZ en-wikipedia-org-9224 332 10 another another DT en-wikipedia-org-9224 332 11 common common JJ en-wikipedia-org-9224 332 12 strategy strategy NN en-wikipedia-org-9224 332 13 for for IN en-wikipedia-org-9224 332 14 avoiding avoid VBG en-wikipedia-org-9224 332 15 detection detection NN en-wikipedia-org-9224 332 16 by by IN en-wikipedia-org-9224 332 17 the the DT en-wikipedia-org-9224 332 18 immune immune JJ en-wikipedia-org-9224 332 19 system system NN en-wikipedia-org-9224 332 20 . . . en-wikipedia-org-9224 333 1 In in IN en-wikipedia-org-9224 333 2 HIV HIV NNP en-wikipedia-org-9224 333 3 , , , en-wikipedia-org-9224 333 4 the the DT en-wikipedia-org-9224 333 5 envelope envelope NN en-wikipedia-org-9224 333 6 that that WDT en-wikipedia-org-9224 333 7 covers cover VBZ en-wikipedia-org-9224 333 8 the the DT en-wikipedia-org-9224 333 9 virion virion NN en-wikipedia-org-9224 333 10 is be VBZ en-wikipedia-org-9224 333 11 formed form VBN en-wikipedia-org-9224 333 12 from from IN en-wikipedia-org-9224 333 13 the the DT en-wikipedia-org-9224 333 14 outermost outermost JJ en-wikipedia-org-9224 333 15 membrane membrane NN en-wikipedia-org-9224 333 16 of of IN en-wikipedia-org-9224 333 17 the the DT en-wikipedia-org-9224 333 18 host host NN en-wikipedia-org-9224 333 19 cell cell NN en-wikipedia-org-9224 333 20 ; ; : en-wikipedia-org-9224 333 21 such such JJ en-wikipedia-org-9224 333 22 " " `` en-wikipedia-org-9224 333 23 self self NN en-wikipedia-org-9224 333 24 - - HYPH en-wikipedia-org-9224 333 25 cloaked cloak VBN en-wikipedia-org-9224 333 26 " " '' en-wikipedia-org-9224 333 27 viruses virus NNS en-wikipedia-org-9224 333 28 make make VBP en-wikipedia-org-9224 333 29 it -PRON- PRP en-wikipedia-org-9224 333 30 difficult difficult JJ en-wikipedia-org-9224 333 31 for for IN en-wikipedia-org-9224 333 32 the the DT en-wikipedia-org-9224 333 33 immune immune JJ en-wikipedia-org-9224 333 34 system system NN en-wikipedia-org-9224 333 35 to to TO en-wikipedia-org-9224 333 36 identify identify VB en-wikipedia-org-9224 333 37 them -PRON- PRP en-wikipedia-org-9224 333 38 as as IN en-wikipedia-org-9224 333 39 " " `` en-wikipedia-org-9224 333 40 non non JJ en-wikipedia-org-9224 333 41 - - JJ en-wikipedia-org-9224 333 42 self self JJ en-wikipedia-org-9224 333 43 " " '' en-wikipedia-org-9224 333 44 structures structure NNS en-wikipedia-org-9224 333 45 . . . en-wikipedia-org-9224 334 1 [ [ -LRB- en-wikipedia-org-9224 334 2 169 169 CD en-wikipedia-org-9224 334 3 ] ] -RRB- en-wikipedia-org-9224 334 4 History history NN en-wikipedia-org-9224 334 5 of of IN en-wikipedia-org-9224 334 6 immunology[edit immunology[edit LS en-wikipedia-org-9224 334 7 ] ] -RRB- en-wikipedia-org-9224 334 8 Further further JJ en-wikipedia-org-9224 334 9 information information NN en-wikipedia-org-9224 334 10 : : : en-wikipedia-org-9224 334 11 History history NN en-wikipedia-org-9224 334 12 of of IN en-wikipedia-org-9224 334 13 immunology immunology NN en-wikipedia-org-9224 334 14 Paul Paul NNP en-wikipedia-org-9224 334 15 Ehrlich Ehrlich NNP en-wikipedia-org-9224 334 16 ( ( -LRB- en-wikipedia-org-9224 334 17 1854–1915 1854–1915 CD en-wikipedia-org-9224 334 18 ) ) -RRB- en-wikipedia-org-9224 334 19 was be VBD en-wikipedia-org-9224 334 20 awarded award VBN en-wikipedia-org-9224 334 21 a a DT en-wikipedia-org-9224 334 22 Nobel Nobel NNP en-wikipedia-org-9224 334 23 Prize Prize NNP en-wikipedia-org-9224 334 24 in in IN en-wikipedia-org-9224 334 25 1908 1908 CD en-wikipedia-org-9224 334 26 for for IN en-wikipedia-org-9224 334 27 his -PRON- PRP$ en-wikipedia-org-9224 334 28 contributions contribution NNS en-wikipedia-org-9224 334 29 to to IN en-wikipedia-org-9224 334 30 immunology immunology NN en-wikipedia-org-9224 334 31 . . . en-wikipedia-org-9224 335 1 [ [ -LRB- en-wikipedia-org-9224 335 2 170 170 CD en-wikipedia-org-9224 335 3 ] ] -RRB- en-wikipedia-org-9224 335 4 Immunology immunology NN en-wikipedia-org-9224 335 5 is be VBZ en-wikipedia-org-9224 335 6 a a DT en-wikipedia-org-9224 335 7 science science NN en-wikipedia-org-9224 335 8 that that WDT en-wikipedia-org-9224 335 9 examines examine VBZ en-wikipedia-org-9224 335 10 the the DT en-wikipedia-org-9224 335 11 structure structure NN en-wikipedia-org-9224 335 12 and and CC en-wikipedia-org-9224 335 13 function function NN en-wikipedia-org-9224 335 14 of of IN en-wikipedia-org-9224 335 15 the the DT en-wikipedia-org-9224 335 16 immune immune JJ en-wikipedia-org-9224 335 17 system system NN en-wikipedia-org-9224 335 18 . . . en-wikipedia-org-9224 336 1 It -PRON- PRP en-wikipedia-org-9224 336 2 originates originate VBZ en-wikipedia-org-9224 336 3 from from IN en-wikipedia-org-9224 336 4 medicine medicine NN en-wikipedia-org-9224 336 5 and and CC en-wikipedia-org-9224 336 6 early early JJ en-wikipedia-org-9224 336 7 studies study NNS en-wikipedia-org-9224 336 8 on on IN en-wikipedia-org-9224 336 9 the the DT en-wikipedia-org-9224 336 10 causes cause NNS en-wikipedia-org-9224 336 11 of of IN en-wikipedia-org-9224 336 12 immunity immunity NN en-wikipedia-org-9224 336 13 to to IN en-wikipedia-org-9224 336 14 disease disease NN en-wikipedia-org-9224 336 15 . . . en-wikipedia-org-9224 337 1 The the DT en-wikipedia-org-9224 337 2 earliest early JJS en-wikipedia-org-9224 337 3 known know VBN en-wikipedia-org-9224 337 4 reference reference NN en-wikipedia-org-9224 337 5 to to IN en-wikipedia-org-9224 337 6 immunity immunity NN en-wikipedia-org-9224 337 7 was be VBD en-wikipedia-org-9224 337 8 during during IN en-wikipedia-org-9224 337 9 the the DT en-wikipedia-org-9224 337 10 plague plague NN en-wikipedia-org-9224 337 11 of of IN en-wikipedia-org-9224 337 12 Athens Athens NNP en-wikipedia-org-9224 337 13 in in IN en-wikipedia-org-9224 337 14 430 430 CD en-wikipedia-org-9224 337 15 BC BC NNP en-wikipedia-org-9224 337 16 . . . en-wikipedia-org-9224 338 1 Thucydides thucydide NNS en-wikipedia-org-9224 338 2 noted note VBD en-wikipedia-org-9224 338 3 that that IN en-wikipedia-org-9224 338 4 people people NNS en-wikipedia-org-9224 338 5 who who WP en-wikipedia-org-9224 338 6 had have VBD en-wikipedia-org-9224 338 7 recovered recover VBN en-wikipedia-org-9224 338 8 from from IN en-wikipedia-org-9224 338 9 a a DT en-wikipedia-org-9224 338 10 previous previous JJ en-wikipedia-org-9224 338 11 bout bout NN en-wikipedia-org-9224 338 12 of of IN en-wikipedia-org-9224 338 13 the the DT en-wikipedia-org-9224 338 14 disease disease NN en-wikipedia-org-9224 338 15 could could MD en-wikipedia-org-9224 338 16 nurse nurse VB en-wikipedia-org-9224 338 17 the the DT en-wikipedia-org-9224 338 18 sick sick JJ en-wikipedia-org-9224 338 19 without without IN en-wikipedia-org-9224 338 20 contracting contract VBG en-wikipedia-org-9224 338 21 the the DT en-wikipedia-org-9224 338 22 illness illness NN en-wikipedia-org-9224 338 23 a a DT en-wikipedia-org-9224 338 24 second second JJ en-wikipedia-org-9224 338 25 time time NN en-wikipedia-org-9224 338 26 . . . en-wikipedia-org-9224 339 1 [ [ -LRB- en-wikipedia-org-9224 339 2 171 171 CD en-wikipedia-org-9224 339 3 ] ] -RRB- en-wikipedia-org-9224 339 4 In in IN en-wikipedia-org-9224 339 5 the the DT en-wikipedia-org-9224 339 6 18th 18th JJ en-wikipedia-org-9224 339 7 century century NN en-wikipedia-org-9224 339 8 , , , en-wikipedia-org-9224 339 9 Pierre Pierre NNP en-wikipedia-org-9224 339 10 - - HYPH en-wikipedia-org-9224 339 11 Louis Louis NNP en-wikipedia-org-9224 339 12 Moreau Moreau NNP en-wikipedia-org-9224 339 13 de de NNP en-wikipedia-org-9224 339 14 Maupertuis Maupertuis NNP en-wikipedia-org-9224 339 15 experimented experiment VBD en-wikipedia-org-9224 339 16 with with IN en-wikipedia-org-9224 339 17 scorpion scorpion NN en-wikipedia-org-9224 339 18 venom venom NN en-wikipedia-org-9224 339 19 and and CC en-wikipedia-org-9224 339 20 observed observe VBD en-wikipedia-org-9224 339 21 that that IN en-wikipedia-org-9224 339 22 certain certain JJ en-wikipedia-org-9224 339 23 dogs dog NNS en-wikipedia-org-9224 339 24 and and CC en-wikipedia-org-9224 339 25 mice mouse NNS en-wikipedia-org-9224 339 26 were be VBD en-wikipedia-org-9224 339 27 immune immune JJ en-wikipedia-org-9224 339 28 to to IN en-wikipedia-org-9224 339 29 this this DT en-wikipedia-org-9224 339 30 venom venom NN en-wikipedia-org-9224 339 31 . . . en-wikipedia-org-9224 340 1 [ [ -LRB- en-wikipedia-org-9224 340 2 172 172 CD en-wikipedia-org-9224 340 3 ] ] -RRB- en-wikipedia-org-9224 340 4 In in IN en-wikipedia-org-9224 340 5 the the DT en-wikipedia-org-9224 340 6 10th 10th JJ en-wikipedia-org-9224 340 7 century century NN en-wikipedia-org-9224 340 8 , , , en-wikipedia-org-9224 340 9 Persian persian JJ en-wikipedia-org-9224 340 10 physician physician NN en-wikipedia-org-9224 340 11 al al NNP en-wikipedia-org-9224 340 12 - - HYPH en-wikipedia-org-9224 340 13 Razi Razi NNP en-wikipedia-org-9224 340 14 ( ( -LRB- en-wikipedia-org-9224 340 15 also also RB en-wikipedia-org-9224 340 16 known know VBN en-wikipedia-org-9224 340 17 as as IN en-wikipedia-org-9224 340 18 Rhazes Rhazes NNPS en-wikipedia-org-9224 340 19 ) ) -RRB- en-wikipedia-org-9224 340 20 wrote write VBD en-wikipedia-org-9224 340 21 the the DT en-wikipedia-org-9224 340 22 first first JJ en-wikipedia-org-9224 340 23 recorded recorded JJ en-wikipedia-org-9224 340 24 theory theory NN en-wikipedia-org-9224 340 25 of of IN en-wikipedia-org-9224 340 26 acquired acquire VBN en-wikipedia-org-9224 340 27 immunity,[173][174 immunity,[173][174 NNP en-wikipedia-org-9224 340 28 ] ] -RRB- en-wikipedia-org-9224 340 29 noting note VBG en-wikipedia-org-9224 340 30 that that IN en-wikipedia-org-9224 340 31 a a DT en-wikipedia-org-9224 340 32 smallpox smallpox NN en-wikipedia-org-9224 340 33 bout bout NN en-wikipedia-org-9224 340 34 protected protect VBD en-wikipedia-org-9224 340 35 its -PRON- PRP$ en-wikipedia-org-9224 340 36 survivors survivor NNS en-wikipedia-org-9224 340 37 from from IN en-wikipedia-org-9224 340 38 future future JJ en-wikipedia-org-9224 340 39 infections infection NNS en-wikipedia-org-9224 340 40 . . . en-wikipedia-org-9224 341 1 Although although IN en-wikipedia-org-9224 341 2 he -PRON- PRP en-wikipedia-org-9224 341 3 explained explain VBD en-wikipedia-org-9224 341 4 the the DT en-wikipedia-org-9224 341 5 immunity immunity NN en-wikipedia-org-9224 341 6 in in IN en-wikipedia-org-9224 341 7 terms term NNS en-wikipedia-org-9224 341 8 of of IN en-wikipedia-org-9224 341 9 " " `` en-wikipedia-org-9224 341 10 excess excess JJ en-wikipedia-org-9224 341 11 moisture moisture NN en-wikipedia-org-9224 341 12 " " '' en-wikipedia-org-9224 341 13 being be VBG en-wikipedia-org-9224 341 14 expelled expel VBN en-wikipedia-org-9224 341 15 from from IN en-wikipedia-org-9224 341 16 the the DT en-wikipedia-org-9224 341 17 blood blood NN en-wikipedia-org-9224 341 18 — — : en-wikipedia-org-9224 341 19 therefore therefore RB en-wikipedia-org-9224 341 20 preventing prevent VBG en-wikipedia-org-9224 341 21 a a DT en-wikipedia-org-9224 341 22 second second JJ en-wikipedia-org-9224 341 23 occurrence occurrence NN en-wikipedia-org-9224 341 24 of of IN en-wikipedia-org-9224 341 25 the the DT en-wikipedia-org-9224 341 26 disease disease NN en-wikipedia-org-9224 341 27 — — : en-wikipedia-org-9224 341 28 this this DT en-wikipedia-org-9224 341 29 theory theory NN en-wikipedia-org-9224 341 30 explained explain VBD en-wikipedia-org-9224 341 31 many many JJ en-wikipedia-org-9224 341 32 observations observation NNS en-wikipedia-org-9224 341 33 about about IN en-wikipedia-org-9224 341 34 smallpox smallpox NN en-wikipedia-org-9224 341 35 known know VBN en-wikipedia-org-9224 341 36 during during IN en-wikipedia-org-9224 341 37 this this DT en-wikipedia-org-9224 341 38 time time NN en-wikipedia-org-9224 341 39 . . . en-wikipedia-org-9224 342 1 [ [ -LRB- en-wikipedia-org-9224 342 2 175 175 CD en-wikipedia-org-9224 342 3 ] ] -RRB- en-wikipedia-org-9224 342 4 These these DT en-wikipedia-org-9224 342 5 and and CC en-wikipedia-org-9224 342 6 other other JJ en-wikipedia-org-9224 342 7 observations observation NNS en-wikipedia-org-9224 342 8 of of IN en-wikipedia-org-9224 342 9 acquired acquire VBN en-wikipedia-org-9224 342 10 immunity immunity NN en-wikipedia-org-9224 342 11 were be VBD en-wikipedia-org-9224 342 12 later later RB en-wikipedia-org-9224 342 13 exploited exploit VBN en-wikipedia-org-9224 342 14 by by IN en-wikipedia-org-9224 342 15 Louis Louis NNP en-wikipedia-org-9224 342 16 Pasteur Pasteur NNP en-wikipedia-org-9224 342 17 in in IN en-wikipedia-org-9224 342 18 his -PRON- PRP$ en-wikipedia-org-9224 342 19 development development NN en-wikipedia-org-9224 342 20 of of IN en-wikipedia-org-9224 342 21 vaccination vaccination NN en-wikipedia-org-9224 342 22 and and CC en-wikipedia-org-9224 342 23 his -PRON- PRP$ en-wikipedia-org-9224 342 24 proposed propose VBN en-wikipedia-org-9224 342 25 germ germ NN en-wikipedia-org-9224 342 26 theory theory NN en-wikipedia-org-9224 342 27 of of IN en-wikipedia-org-9224 342 28 disease disease NN en-wikipedia-org-9224 342 29 . . . en-wikipedia-org-9224 343 1 [ [ -LRB- en-wikipedia-org-9224 343 2 176 176 CD en-wikipedia-org-9224 343 3 ] ] -RRB- en-wikipedia-org-9224 343 4 Pasteur Pasteur NNP en-wikipedia-org-9224 343 5 's 's POS en-wikipedia-org-9224 343 6 theory theory NN en-wikipedia-org-9224 343 7 was be VBD en-wikipedia-org-9224 343 8 in in IN en-wikipedia-org-9224 343 9 direct direct JJ en-wikipedia-org-9224 343 10 opposition opposition NN en-wikipedia-org-9224 343 11 to to IN en-wikipedia-org-9224 343 12 contemporary contemporary JJ en-wikipedia-org-9224 343 13 theories theory NNS en-wikipedia-org-9224 343 14 of of IN en-wikipedia-org-9224 343 15 disease disease NN en-wikipedia-org-9224 343 16 , , , en-wikipedia-org-9224 343 17 such such JJ en-wikipedia-org-9224 343 18 as as IN en-wikipedia-org-9224 343 19 the the DT en-wikipedia-org-9224 343 20 miasma miasma NN en-wikipedia-org-9224 343 21 theory theory NN en-wikipedia-org-9224 343 22 . . . en-wikipedia-org-9224 344 1 It -PRON- PRP en-wikipedia-org-9224 344 2 was be VBD en-wikipedia-org-9224 344 3 not not RB en-wikipedia-org-9224 344 4 until until IN en-wikipedia-org-9224 344 5 Robert Robert NNP en-wikipedia-org-9224 344 6 Koch Koch NNP en-wikipedia-org-9224 344 7 's 's POS en-wikipedia-org-9224 344 8 1891 1891 CD en-wikipedia-org-9224 344 9 proofs proofs NNP en-wikipedia-org-9224 344 10 , , , en-wikipedia-org-9224 344 11 for for IN en-wikipedia-org-9224 344 12 which which WDT en-wikipedia-org-9224 344 13 he -PRON- PRP en-wikipedia-org-9224 344 14 was be VBD en-wikipedia-org-9224 344 15 awarded award VBN en-wikipedia-org-9224 344 16 a a DT en-wikipedia-org-9224 344 17 Nobel Nobel NNP en-wikipedia-org-9224 344 18 Prize Prize NNP en-wikipedia-org-9224 344 19 in in IN en-wikipedia-org-9224 344 20 1905 1905 CD en-wikipedia-org-9224 344 21 , , , en-wikipedia-org-9224 344 22 that that IN en-wikipedia-org-9224 344 23 microorganisms microorganism NNS en-wikipedia-org-9224 344 24 were be VBD en-wikipedia-org-9224 344 25 confirmed confirm VBN en-wikipedia-org-9224 344 26 as as IN en-wikipedia-org-9224 344 27 the the DT en-wikipedia-org-9224 344 28 cause cause NN en-wikipedia-org-9224 344 29 of of IN en-wikipedia-org-9224 344 30 infectious infectious JJ en-wikipedia-org-9224 344 31 disease disease NN en-wikipedia-org-9224 344 32 . . . en-wikipedia-org-9224 345 1 [ [ -LRB- en-wikipedia-org-9224 345 2 177 177 CD en-wikipedia-org-9224 345 3 ] ] -RRB- en-wikipedia-org-9224 345 4 Viruses virus NNS en-wikipedia-org-9224 345 5 were be VBD en-wikipedia-org-9224 345 6 confirmed confirm VBN en-wikipedia-org-9224 345 7 as as IN en-wikipedia-org-9224 345 8 human human JJ en-wikipedia-org-9224 345 9 pathogens pathogen NNS en-wikipedia-org-9224 345 10 in in IN en-wikipedia-org-9224 345 11 1901 1901 CD en-wikipedia-org-9224 345 12 , , , en-wikipedia-org-9224 345 13 with with IN en-wikipedia-org-9224 345 14 the the DT en-wikipedia-org-9224 345 15 discovery discovery NN en-wikipedia-org-9224 345 16 of of IN en-wikipedia-org-9224 345 17 the the DT en-wikipedia-org-9224 345 18 yellow yellow JJ en-wikipedia-org-9224 345 19 fever fever NN en-wikipedia-org-9224 345 20 virus virus NN en-wikipedia-org-9224 345 21 by by IN en-wikipedia-org-9224 345 22 Walter Walter NNP en-wikipedia-org-9224 345 23 Reed Reed NNP en-wikipedia-org-9224 345 24 . . . en-wikipedia-org-9224 346 1 [ [ -LRB- en-wikipedia-org-9224 346 2 178 178 CD en-wikipedia-org-9224 346 3 ] ] -RRB- en-wikipedia-org-9224 346 4 Immunology immunology NN en-wikipedia-org-9224 346 5 made make VBD en-wikipedia-org-9224 346 6 a a DT en-wikipedia-org-9224 346 7 great great JJ en-wikipedia-org-9224 346 8 advance advance NN en-wikipedia-org-9224 346 9 towards towards IN en-wikipedia-org-9224 346 10 the the DT en-wikipedia-org-9224 346 11 end end NN en-wikipedia-org-9224 346 12 of of IN en-wikipedia-org-9224 346 13 the the DT en-wikipedia-org-9224 346 14 19th 19th JJ en-wikipedia-org-9224 346 15 century century NN en-wikipedia-org-9224 346 16 , , , en-wikipedia-org-9224 346 17 through through IN en-wikipedia-org-9224 346 18 rapid rapid JJ en-wikipedia-org-9224 346 19 developments development NNS en-wikipedia-org-9224 346 20 in in IN en-wikipedia-org-9224 346 21 the the DT en-wikipedia-org-9224 346 22 study study NN en-wikipedia-org-9224 346 23 of of IN en-wikipedia-org-9224 346 24 humoral humoral JJ en-wikipedia-org-9224 346 25 immunity immunity NN en-wikipedia-org-9224 346 26 and and CC en-wikipedia-org-9224 346 27 cellular cellular JJ en-wikipedia-org-9224 346 28 immunity immunity NN en-wikipedia-org-9224 346 29 . . . en-wikipedia-org-9224 347 1 [ [ -LRB- en-wikipedia-org-9224 347 2 179 179 CD en-wikipedia-org-9224 347 3 ] ] -RRB- en-wikipedia-org-9224 347 4 Particularly particularly RB en-wikipedia-org-9224 347 5 important important JJ en-wikipedia-org-9224 347 6 was be VBD en-wikipedia-org-9224 347 7 the the DT en-wikipedia-org-9224 347 8 work work NN en-wikipedia-org-9224 347 9 of of IN en-wikipedia-org-9224 347 10 Paul Paul NNP en-wikipedia-org-9224 347 11 Ehrlich Ehrlich NNP en-wikipedia-org-9224 347 12 , , , en-wikipedia-org-9224 347 13 who who WP en-wikipedia-org-9224 347 14 proposed propose VBD en-wikipedia-org-9224 347 15 the the DT en-wikipedia-org-9224 347 16 side side NN en-wikipedia-org-9224 347 17 - - HYPH en-wikipedia-org-9224 347 18 chain chain NN en-wikipedia-org-9224 347 19 theory theory NN en-wikipedia-org-9224 347 20 to to TO en-wikipedia-org-9224 347 21 explain explain VB en-wikipedia-org-9224 347 22 the the DT en-wikipedia-org-9224 347 23 specificity specificity NN en-wikipedia-org-9224 347 24 of of IN en-wikipedia-org-9224 347 25 the the DT en-wikipedia-org-9224 347 26 antigen antigen NN en-wikipedia-org-9224 347 27 - - HYPH en-wikipedia-org-9224 347 28 antibody antibody NN en-wikipedia-org-9224 347 29 reaction reaction NN en-wikipedia-org-9224 347 30 ; ; : en-wikipedia-org-9224 347 31 his -PRON- PRP$ en-wikipedia-org-9224 347 32 contributions contribution NNS en-wikipedia-org-9224 347 33 to to IN en-wikipedia-org-9224 347 34 the the DT en-wikipedia-org-9224 347 35 understanding understanding NN en-wikipedia-org-9224 347 36 of of IN en-wikipedia-org-9224 347 37 humoral humoral JJ en-wikipedia-org-9224 347 38 immunity immunity NN en-wikipedia-org-9224 347 39 were be VBD en-wikipedia-org-9224 347 40 recognized recognize VBN en-wikipedia-org-9224 347 41 by by IN en-wikipedia-org-9224 347 42 the the DT en-wikipedia-org-9224 347 43 award award NN en-wikipedia-org-9224 347 44 of of IN en-wikipedia-org-9224 347 45 a a DT en-wikipedia-org-9224 347 46 joint joint JJ en-wikipedia-org-9224 347 47 Nobel Nobel NNP en-wikipedia-org-9224 347 48 Prize Prize NNP en-wikipedia-org-9224 347 49 in in IN en-wikipedia-org-9224 347 50 1908 1908 CD en-wikipedia-org-9224 347 51 , , , en-wikipedia-org-9224 347 52 along along IN en-wikipedia-org-9224 347 53 with with IN en-wikipedia-org-9224 347 54 the the DT en-wikipedia-org-9224 347 55 founder founder NN en-wikipedia-org-9224 347 56 of of IN en-wikipedia-org-9224 347 57 cellular cellular JJ en-wikipedia-org-9224 347 58 immunology immunology NN en-wikipedia-org-9224 347 59 , , , en-wikipedia-org-9224 347 60 Elie Elie NNP en-wikipedia-org-9224 347 61 Metchnikoff Metchnikoff NNP en-wikipedia-org-9224 347 62 . . . en-wikipedia-org-9224 348 1 [ [ -LRB- en-wikipedia-org-9224 348 2 170 170 CD en-wikipedia-org-9224 348 3 ] ] -RRB- en-wikipedia-org-9224 348 4 In in IN en-wikipedia-org-9224 348 5 1974 1974 CD en-wikipedia-org-9224 348 6 , , , en-wikipedia-org-9224 348 7 Niels Niels NNP en-wikipedia-org-9224 348 8 Kaj Kaj NNP en-wikipedia-org-9224 348 9 Jerne Jerne NNP en-wikipedia-org-9224 348 10 developed develop VBD en-wikipedia-org-9224 348 11 the the DT en-wikipedia-org-9224 348 12 immune immune JJ en-wikipedia-org-9224 348 13 network network NN en-wikipedia-org-9224 348 14 theory theory NN en-wikipedia-org-9224 348 15 ; ; : en-wikipedia-org-9224 348 16 he -PRON- PRP en-wikipedia-org-9224 348 17 shared share VBD en-wikipedia-org-9224 348 18 a a DT en-wikipedia-org-9224 348 19 Nobel Nobel NNP en-wikipedia-org-9224 348 20 Prize Prize NNP en-wikipedia-org-9224 348 21 in in IN en-wikipedia-org-9224 348 22 1984 1984 CD en-wikipedia-org-9224 348 23 with with IN en-wikipedia-org-9224 348 24 Georges Georges NNP en-wikipedia-org-9224 348 25 J. J. NNP en-wikipedia-org-9224 348 26 F. F. NNP en-wikipedia-org-9224 348 27 Köhler Köhler NNP en-wikipedia-org-9224 348 28 and and CC en-wikipedia-org-9224 348 29 César César NNP en-wikipedia-org-9224 348 30 Milstein Milstein NNP en-wikipedia-org-9224 348 31 for for IN en-wikipedia-org-9224 348 32 theories theory NNS en-wikipedia-org-9224 348 33 related relate VBN en-wikipedia-org-9224 348 34 to to IN en-wikipedia-org-9224 348 35 the the DT en-wikipedia-org-9224 348 36 immune immune JJ en-wikipedia-org-9224 348 37 system system NN en-wikipedia-org-9224 348 38 . . . en-wikipedia-org-9224 349 1 [ [ -LRB- en-wikipedia-org-9224 349 2 180][181 180][181 LS en-wikipedia-org-9224 349 3 ] ] -RRB- en-wikipedia-org-9224 349 4 See see VB en-wikipedia-org-9224 349 5 also[edit also[edit NFP en-wikipedia-org-9224 349 6 ] ] -RRB- en-wikipedia-org-9224 349 7 Fc Fc NNP en-wikipedia-org-9224 349 8 receptor receptor NN en-wikipedia-org-9224 349 9 Immune immune JJ en-wikipedia-org-9224 349 10 system system NN en-wikipedia-org-9224 349 11 receptors receptor VBZ en-wikipedia-org-9224 349 12 Immunostimulator Immunostimulator NNP en-wikipedia-org-9224 349 13 Original original JJ en-wikipedia-org-9224 349 14 antigenic antigenic JJ en-wikipedia-org-9224 349 15 sin sin NN en-wikipedia-org-9224 349 16 – – : en-wikipedia-org-9224 349 17 when when WRB en-wikipedia-org-9224 349 18 the the DT en-wikipedia-org-9224 349 19 immune immune JJ en-wikipedia-org-9224 349 20 system system NN en-wikipedia-org-9224 349 21 uses use VBZ en-wikipedia-org-9224 349 22 immunological immunological JJ en-wikipedia-org-9224 349 23 memory memory NN en-wikipedia-org-9224 349 24 upon upon IN en-wikipedia-org-9224 349 25 encountering encounter VBG en-wikipedia-org-9224 349 26 a a DT en-wikipedia-org-9224 349 27 slightly slightly RB en-wikipedia-org-9224 349 28 different different JJ en-wikipedia-org-9224 349 29 pathogen pathogen NN en-wikipedia-org-9224 349 30 Plant plant NN en-wikipedia-org-9224 349 31 disease disease NN en-wikipedia-org-9224 349 32 resistance resistance NN en-wikipedia-org-9224 349 33 Polyclonal polyclonal JJ en-wikipedia-org-9224 349 34 response response NN en-wikipedia-org-9224 349 35 Tumor Tumor NNP en-wikipedia-org-9224 349 36 antigens antigen VBZ en-wikipedia-org-9224 349 37 References[edit references[edit NN en-wikipedia-org-9224 349 38 ] ] -RRB- en-wikipedia-org-9224 349 39 ^ ^ NN en-wikipedia-org-9224 349 40 Sompayrac Sompayrac NNP en-wikipedia-org-9224 349 41 2019 2019 CD en-wikipedia-org-9224 349 42 , , , en-wikipedia-org-9224 349 43 p. p. NN en-wikipedia-org-9224 349 44   _SP en-wikipedia-org-9224 349 45 1 1 CD en-wikipedia-org-9224 349 46 . . . en-wikipedia-org-9224 350 1 ^ ^ NNP en-wikipedia-org-9224 350 2 a a DT en-wikipedia-org-9224 350 3 b b NN en-wikipedia-org-9224 350 4 Litman Litman NNP en-wikipedia-org-9224 350 5 GW GW NNP en-wikipedia-org-9224 350 6 , , , en-wikipedia-org-9224 350 7 Cannon Cannon NNP en-wikipedia-org-9224 350 8 JP JP NNP en-wikipedia-org-9224 350 9 , , , en-wikipedia-org-9224 350 10 Dishaw Dishaw NNP en-wikipedia-org-9224 350 11 LJ LJ NNP en-wikipedia-org-9224 350 12 ( ( -LRB- en-wikipedia-org-9224 350 13 November November NNP en-wikipedia-org-9224 350 14 2005 2005 CD en-wikipedia-org-9224 350 15 ) ) -RRB- en-wikipedia-org-9224 350 16 . . . en-wikipedia-org-9224 351 1 " " `` en-wikipedia-org-9224 351 2 Reconstructing reconstruct VBG en-wikipedia-org-9224 351 3 immune immune JJ en-wikipedia-org-9224 351 4 phylogeny phylogeny NN en-wikipedia-org-9224 351 5 : : : en-wikipedia-org-9224 351 6 new new JJ en-wikipedia-org-9224 351 7 perspectives perspective NNS en-wikipedia-org-9224 351 8 " " '' en-wikipedia-org-9224 351 9 . . . en-wikipedia-org-9224 352 1 Nature Nature NNP en-wikipedia-org-9224 352 2 Reviews Reviews NNPS en-wikipedia-org-9224 352 3 . . . en-wikipedia-org-9224 353 1 Immunology immunology NN en-wikipedia-org-9224 353 2 . . . en-wikipedia-org-9224 354 1 5 5 CD en-wikipedia-org-9224 354 2 ( ( -LRB- en-wikipedia-org-9224 354 3 11 11 CD en-wikipedia-org-9224 354 4 ) ) -RRB- en-wikipedia-org-9224 354 5 : : : en-wikipedia-org-9224 354 6 866–79 866–79 CD en-wikipedia-org-9224 354 7 . . . en-wikipedia-org-9224 355 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 355 2 / / SYM en-wikipedia-org-9224 355 3 nri1712 nri1712 NNP en-wikipedia-org-9224 355 4 . . . en-wikipedia-org-9224 356 1 PMC PMC NNP en-wikipedia-org-9224 356 2   _SP en-wikipedia-org-9224 356 3 3683834 3683834 CD en-wikipedia-org-9224 356 4 . . . en-wikipedia-org-9224 357 1 PMID PMID NNP en-wikipedia-org-9224 357 2   _SP en-wikipedia-org-9224 357 3 16261174 16261174 CD en-wikipedia-org-9224 357 4 . . . en-wikipedia-org-9224 358 1 ^ ^ NNP en-wikipedia-org-9224 358 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 358 3 2019 2019 CD en-wikipedia-org-9224 358 4 , , , en-wikipedia-org-9224 358 5 p. p. NN en-wikipedia-org-9224 358 6   _SP en-wikipedia-org-9224 358 7 4 4 CD en-wikipedia-org-9224 358 8 . . . en-wikipedia-org-9224 359 1 ^ ^ NNP en-wikipedia-org-9224 359 2 Restifo Restifo NNP en-wikipedia-org-9224 359 3 NP NP NNP en-wikipedia-org-9224 359 4 , , , en-wikipedia-org-9224 359 5 Gattinoni Gattinoni NNP en-wikipedia-org-9224 359 6 L L NNP en-wikipedia-org-9224 359 7 ( ( -LRB- en-wikipedia-org-9224 359 8 October October NNP en-wikipedia-org-9224 359 9 2013 2013 CD en-wikipedia-org-9224 359 10 ) ) -RRB- en-wikipedia-org-9224 359 11 . . . en-wikipedia-org-9224 360 1 " " `` en-wikipedia-org-9224 360 2 Lineage lineage NN en-wikipedia-org-9224 360 3 relationship relationship NN en-wikipedia-org-9224 360 4 of of IN en-wikipedia-org-9224 360 5 effector effector NN en-wikipedia-org-9224 360 6 and and CC en-wikipedia-org-9224 360 7 memory memory NN en-wikipedia-org-9224 360 8 T t NN en-wikipedia-org-9224 360 9 cells cell NNS en-wikipedia-org-9224 360 10 " " '' en-wikipedia-org-9224 360 11 . . . en-wikipedia-org-9224 361 1 Current current JJ en-wikipedia-org-9224 361 2 Opinion Opinion NNP en-wikipedia-org-9224 361 3 in in IN en-wikipedia-org-9224 361 4 Immunology Immunology NNP en-wikipedia-org-9224 361 5 . . . en-wikipedia-org-9224 362 1 25 25 CD en-wikipedia-org-9224 362 2 ( ( -LRB- en-wikipedia-org-9224 362 3 5 5 CD en-wikipedia-org-9224 362 4 ) ) -RRB- en-wikipedia-org-9224 362 5 : : : en-wikipedia-org-9224 362 6 556–63 556–63 CD en-wikipedia-org-9224 362 7 . . . en-wikipedia-org-9224 363 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 363 2 / / SYM en-wikipedia-org-9224 363 3 j.coi.2013.09.003 j.coi.2013.09.003 NN en-wikipedia-org-9224 363 4 . . . en-wikipedia-org-9224 364 1 PMC PMC NNP en-wikipedia-org-9224 364 2   _SP en-wikipedia-org-9224 364 3 3858177 3858177 CD en-wikipedia-org-9224 364 4 . . . en-wikipedia-org-9224 365 1 PMID PMID NNP en-wikipedia-org-9224 365 2   _SP en-wikipedia-org-9224 365 3 24148236 24148236 CD en-wikipedia-org-9224 365 4 . . . en-wikipedia-org-9224 366 1 ^ ^ NNP en-wikipedia-org-9224 366 2 Kurosaki Kurosaki NNP en-wikipedia-org-9224 366 3 T T NNP en-wikipedia-org-9224 366 4 , , , en-wikipedia-org-9224 366 5 Kometani Kometani NNP en-wikipedia-org-9224 366 6 K K NNP en-wikipedia-org-9224 366 7 , , , en-wikipedia-org-9224 366 8 Ise Ise NNP en-wikipedia-org-9224 366 9 W W NNP en-wikipedia-org-9224 366 10 ( ( -LRB- en-wikipedia-org-9224 366 11 March March NNP en-wikipedia-org-9224 366 12 2015 2015 CD en-wikipedia-org-9224 366 13 ) ) -RRB- en-wikipedia-org-9224 366 14 . . . en-wikipedia-org-9224 367 1 " " `` en-wikipedia-org-9224 367 2 Memory memory NN en-wikipedia-org-9224 367 3 B b NN en-wikipedia-org-9224 367 4 cells cell NNS en-wikipedia-org-9224 367 5 " " '' en-wikipedia-org-9224 367 6 . . . en-wikipedia-org-9224 368 1 Nature Nature NNP en-wikipedia-org-9224 368 2 Reviews Reviews NNPS en-wikipedia-org-9224 368 3 . . . en-wikipedia-org-9224 369 1 Immunology immunology NN en-wikipedia-org-9224 369 2 . . . en-wikipedia-org-9224 370 1 15 15 CD en-wikipedia-org-9224 370 2 ( ( -LRB- en-wikipedia-org-9224 370 3 3 3 CD en-wikipedia-org-9224 370 4 ) ) -RRB- en-wikipedia-org-9224 370 5 : : : en-wikipedia-org-9224 370 6 149–59 149–59 CD en-wikipedia-org-9224 370 7 . . . en-wikipedia-org-9224 371 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 371 2 / / SYM en-wikipedia-org-9224 371 3 nri3802 nri3802 NNP en-wikipedia-org-9224 371 4 . . . en-wikipedia-org-9224 372 1 PMID PMID NNP en-wikipedia-org-9224 372 2   _SP en-wikipedia-org-9224 372 3 25677494 25677494 CD en-wikipedia-org-9224 372 4 . . . en-wikipedia-org-9224 373 1 S2CID S2CID NNS en-wikipedia-org-9224 373 2   _SP en-wikipedia-org-9224 373 3 20825732 20825732 CD en-wikipedia-org-9224 373 4 . . . en-wikipedia-org-9224 374 1 ^ ^ NNP en-wikipedia-org-9224 374 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 374 3 2019 2019 CD en-wikipedia-org-9224 374 4 , , , en-wikipedia-org-9224 374 5 p. p. NN en-wikipedia-org-9224 374 6   _SP en-wikipedia-org-9224 374 7 11 11 CD en-wikipedia-org-9224 374 8 . . . en-wikipedia-org-9224 375 1 ^ ^ NNP en-wikipedia-org-9224 375 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 375 3 2019 2019 CD en-wikipedia-org-9224 375 4 , , , en-wikipedia-org-9224 375 5 p. p. NN en-wikipedia-org-9224 375 6   _SP en-wikipedia-org-9224 375 7 146 146 CD en-wikipedia-org-9224 375 8 . . . en-wikipedia-org-9224 376 1 ^ ^ NNP en-wikipedia-org-9224 376 2 Alberts Alberts NNP en-wikipedia-org-9224 376 3 et et FW en-wikipedia-org-9224 376 4 al al NNP en-wikipedia-org-9224 376 5 . . . en-wikipedia-org-9224 377 1 2002 2002 CD en-wikipedia-org-9224 377 2 , , , en-wikipedia-org-9224 377 3 sec sec NNP en-wikipedia-org-9224 377 4 . . . en-wikipedia-org-9224 378 1 " " `` en-wikipedia-org-9224 378 2 Pathogens pathogen VBZ en-wikipedia-org-9224 378 3 Cross Cross NNP en-wikipedia-org-9224 378 4 Protective Protective NNP en-wikipedia-org-9224 378 5 Barriers Barriers NNPS en-wikipedia-org-9224 378 6 to to TO en-wikipedia-org-9224 378 7 Colonize colonize VB en-wikipedia-org-9224 378 8 the the DT en-wikipedia-org-9224 378 9 Host host NN en-wikipedia-org-9224 378 10 " " '' en-wikipedia-org-9224 378 11 . . . en-wikipedia-org-9224 379 1 ^ ^ NNP en-wikipedia-org-9224 379 2 Boyton Boyton NNP en-wikipedia-org-9224 379 3 RJ RJ NNP en-wikipedia-org-9224 379 4 , , , en-wikipedia-org-9224 379 5 Openshaw Openshaw NNP en-wikipedia-org-9224 379 6 PJ PJ NNP en-wikipedia-org-9224 379 7 ( ( -LRB- en-wikipedia-org-9224 379 8 2002 2002 CD en-wikipedia-org-9224 379 9 ) ) -RRB- en-wikipedia-org-9224 379 10 . . . en-wikipedia-org-9224 380 1 " " `` en-wikipedia-org-9224 380 2 Pulmonary pulmonary JJ en-wikipedia-org-9224 380 3 defences defence NNS en-wikipedia-org-9224 380 4 to to TO en-wikipedia-org-9224 380 5 acute acute VB en-wikipedia-org-9224 380 6 respiratory respiratory JJ en-wikipedia-org-9224 380 7 infection infection NN en-wikipedia-org-9224 380 8 " " '' en-wikipedia-org-9224 380 9 . . . en-wikipedia-org-9224 381 1 British British NNP en-wikipedia-org-9224 381 2 Medical Medical NNP en-wikipedia-org-9224 381 3 Bulletin Bulletin NNP en-wikipedia-org-9224 381 4 . . . en-wikipedia-org-9224 382 1 61 61 CD en-wikipedia-org-9224 382 2 ( ( -LRB- en-wikipedia-org-9224 382 3 1 1 CD en-wikipedia-org-9224 382 4 ) ) -RRB- en-wikipedia-org-9224 382 5 : : : en-wikipedia-org-9224 382 6 1–12 1–12 CD en-wikipedia-org-9224 382 7 . . . en-wikipedia-org-9224 383 1 doi:10.1093 doi:10.1093 NNP en-wikipedia-org-9224 383 2 / / SYM en-wikipedia-org-9224 383 3 bmb/61.1.1 bmb/61.1.1 NNP en-wikipedia-org-9224 383 4 . . . en-wikipedia-org-9224 384 1 PMID PMID NNP en-wikipedia-org-9224 384 2   _SP en-wikipedia-org-9224 384 3 11997295 11997295 CD en-wikipedia-org-9224 384 4 . . . en-wikipedia-org-9224 385 1 ^ ^ NFP en-wikipedia-org-9224 385 2 Agerberth Agerberth NNP en-wikipedia-org-9224 385 3 B B NNP en-wikipedia-org-9224 385 4 , , , en-wikipedia-org-9224 385 5 Gudmundsson Gudmundsson NNP en-wikipedia-org-9224 385 6 GH GH NNP en-wikipedia-org-9224 385 7 ( ( -LRB- en-wikipedia-org-9224 385 8 2006 2006 CD en-wikipedia-org-9224 385 9 ) ) -RRB- en-wikipedia-org-9224 385 10 . . . en-wikipedia-org-9224 386 1 " " `` en-wikipedia-org-9224 386 2 Host host NN en-wikipedia-org-9224 386 3 antimicrobial antimicrobial JJ en-wikipedia-org-9224 386 4 defence defence NN en-wikipedia-org-9224 386 5 peptides peptide NNS en-wikipedia-org-9224 386 6 in in IN en-wikipedia-org-9224 386 7 human human JJ en-wikipedia-org-9224 386 8 disease disease NN en-wikipedia-org-9224 386 9 " " '' en-wikipedia-org-9224 386 10 . . . en-wikipedia-org-9224 387 1 Current current JJ en-wikipedia-org-9224 387 2 Topics Topics NNPS en-wikipedia-org-9224 387 3 in in IN en-wikipedia-org-9224 387 4 Microbiology Microbiology NNP en-wikipedia-org-9224 387 5 and and CC en-wikipedia-org-9224 387 6 Immunology immunology NN en-wikipedia-org-9224 387 7 . . . en-wikipedia-org-9224 388 1 306 306 CD en-wikipedia-org-9224 388 2 : : SYM en-wikipedia-org-9224 388 3 67–90 67–90 CD en-wikipedia-org-9224 388 4 . . . en-wikipedia-org-9224 389 1 doi:10.1007/3 doi:10.1007/3 : en-wikipedia-org-9224 389 2 - - HYPH en-wikipedia-org-9224 389 3 540 540 CD en-wikipedia-org-9224 389 4 - - HYPH en-wikipedia-org-9224 389 5 29916 29916 CD en-wikipedia-org-9224 389 6 - - HYPH en-wikipedia-org-9224 389 7 5_3 5_3 CD en-wikipedia-org-9224 389 8 . . . en-wikipedia-org-9224 390 1 ISBN ISBN NNP en-wikipedia-org-9224 390 2   _SP en-wikipedia-org-9224 390 3 978 978 CD en-wikipedia-org-9224 390 4 - - HYPH en-wikipedia-org-9224 390 5 3 3 CD en-wikipedia-org-9224 390 6 - - HYPH en-wikipedia-org-9224 390 7 540 540 CD en-wikipedia-org-9224 390 8 - - HYPH en-wikipedia-org-9224 390 9 29915 29915 CD en-wikipedia-org-9224 390 10 - - HYPH en-wikipedia-org-9224 390 11 8 8 CD en-wikipedia-org-9224 390 12 . . . en-wikipedia-org-9224 391 1 PMID PMID NNP en-wikipedia-org-9224 391 2   _SP en-wikipedia-org-9224 391 3 16909918 16909918 CD en-wikipedia-org-9224 391 4 . . . en-wikipedia-org-9224 392 1 ^ ^ NNP en-wikipedia-org-9224 392 2 Moreau Moreau NNP en-wikipedia-org-9224 392 3 JM JM NNP en-wikipedia-org-9224 392 4 , , , en-wikipedia-org-9224 392 5 Girgis Girgis NNP en-wikipedia-org-9224 392 6 DO DO NNP en-wikipedia-org-9224 392 7 , , , en-wikipedia-org-9224 392 8 Hume hume VB en-wikipedia-org-9224 392 9 EB EB NNP en-wikipedia-org-9224 392 10 , , , en-wikipedia-org-9224 392 11 Dajcs Dajcs NNP en-wikipedia-org-9224 392 12 JJ JJ NNP en-wikipedia-org-9224 392 13 , , , en-wikipedia-org-9224 392 14 Austin Austin NNP en-wikipedia-org-9224 392 15 MS MS NNP en-wikipedia-org-9224 392 16 , , , en-wikipedia-org-9224 392 17 O'Callaghan O'Callaghan NNP en-wikipedia-org-9224 392 18 RJ RJ NNP en-wikipedia-org-9224 392 19 ( ( -LRB- en-wikipedia-org-9224 392 20 September September NNP en-wikipedia-org-9224 392 21 2001 2001 CD en-wikipedia-org-9224 392 22 ) ) -RRB- en-wikipedia-org-9224 392 23 . . . en-wikipedia-org-9224 393 1 " " `` en-wikipedia-org-9224 393 2 Phospholipase Phospholipase NNP en-wikipedia-org-9224 393 3 A(2 A(2 NFP en-wikipedia-org-9224 393 4 ) ) -RRB- en-wikipedia-org-9224 393 5 in in IN en-wikipedia-org-9224 393 6 rabbit rabbit NN en-wikipedia-org-9224 393 7 tears tear NNS en-wikipedia-org-9224 393 8 : : : en-wikipedia-org-9224 393 9 a a DT en-wikipedia-org-9224 393 10 host host NN en-wikipedia-org-9224 393 11 defense defense NN en-wikipedia-org-9224 393 12 against against IN en-wikipedia-org-9224 393 13 Staphylococcus Staphylococcus NNP en-wikipedia-org-9224 393 14 aureus aureus NNP en-wikipedia-org-9224 393 15 " " '' en-wikipedia-org-9224 393 16 . . . en-wikipedia-org-9224 394 1 Investigative Investigative NNP en-wikipedia-org-9224 394 2 Ophthalmology Ophthalmology NNP en-wikipedia-org-9224 394 3 & & CC en-wikipedia-org-9224 394 4 Visual Visual NNP en-wikipedia-org-9224 394 5 Science Science NNP en-wikipedia-org-9224 394 6 . . . en-wikipedia-org-9224 395 1 42 42 CD en-wikipedia-org-9224 395 2 ( ( -LRB- en-wikipedia-org-9224 395 3 10 10 CD en-wikipedia-org-9224 395 4 ) ) -RRB- en-wikipedia-org-9224 395 5 : : : en-wikipedia-org-9224 395 6 2347–54 2347–54 LS en-wikipedia-org-9224 395 7 . . . en-wikipedia-org-9224 396 1 PMID PMID NNP en-wikipedia-org-9224 396 2   _SP en-wikipedia-org-9224 396 3 11527949 11527949 CD en-wikipedia-org-9224 396 4 . . . en-wikipedia-org-9224 397 1 ^ ^ NNP en-wikipedia-org-9224 397 2 Hankiewicz Hankiewicz NNP en-wikipedia-org-9224 397 3 J J NNP en-wikipedia-org-9224 397 4 , , , en-wikipedia-org-9224 397 5 Swierczek Swierczek NNP en-wikipedia-org-9224 397 6 E e NN en-wikipedia-org-9224 397 7 ( ( -LRB- en-wikipedia-org-9224 397 8 December December NNP en-wikipedia-org-9224 397 9 1974 1974 CD en-wikipedia-org-9224 397 10 ) ) -RRB- en-wikipedia-org-9224 397 11 . . . en-wikipedia-org-9224 398 1 " " `` en-wikipedia-org-9224 398 2 Lysozyme Lysozyme NNS en-wikipedia-org-9224 398 3 in in IN en-wikipedia-org-9224 398 4 human human JJ en-wikipedia-org-9224 398 5 body body NN en-wikipedia-org-9224 398 6 fluids fluid NNS en-wikipedia-org-9224 398 7 " " '' en-wikipedia-org-9224 398 8 . . . en-wikipedia-org-9224 399 1 Clinica Clinica NNP en-wikipedia-org-9224 399 2 Chimica Chimica NNP en-wikipedia-org-9224 399 3 Acta Acta NNP en-wikipedia-org-9224 399 4 ; ; : en-wikipedia-org-9224 399 5 International International NNP en-wikipedia-org-9224 399 6 Journal Journal NNP en-wikipedia-org-9224 399 7 of of IN en-wikipedia-org-9224 399 8 Clinical Clinical NNP en-wikipedia-org-9224 399 9 Chemistry Chemistry NNP en-wikipedia-org-9224 399 10 . . . en-wikipedia-org-9224 400 1 57 57 CD en-wikipedia-org-9224 400 2 ( ( -LRB- en-wikipedia-org-9224 400 3 3 3 CD en-wikipedia-org-9224 400 4 ) ) -RRB- en-wikipedia-org-9224 400 5 : : : en-wikipedia-org-9224 400 6 205–09 205–09 CD en-wikipedia-org-9224 400 7 . . . en-wikipedia-org-9224 401 1 doi:10.1016/0009 doi:10.1016/0009 NN en-wikipedia-org-9224 401 2 - - HYPH en-wikipedia-org-9224 401 3 8981(74)90398 8981(74)90398 NNP en-wikipedia-org-9224 401 4 - - HYPH en-wikipedia-org-9224 401 5 2 2 CD en-wikipedia-org-9224 401 6 . . . en-wikipedia-org-9224 402 1 PMID PMID NNP en-wikipedia-org-9224 402 2   _SP en-wikipedia-org-9224 402 3 4434640 4434640 CD en-wikipedia-org-9224 402 4 . . . en-wikipedia-org-9224 403 1 ^ ^ FW en-wikipedia-org-9224 403 2 Fair Fair NNP en-wikipedia-org-9224 403 3 WR WR NNP en-wikipedia-org-9224 403 4 , , , en-wikipedia-org-9224 403 5 Couch Couch NNP en-wikipedia-org-9224 403 6 J J NNP en-wikipedia-org-9224 403 7 , , , en-wikipedia-org-9224 403 8 Wehner Wehner NNP en-wikipedia-org-9224 403 9 N N NNP en-wikipedia-org-9224 403 10 ( ( -LRB- en-wikipedia-org-9224 403 11 February February NNP en-wikipedia-org-9224 403 12 1976 1976 CD en-wikipedia-org-9224 403 13 ) ) -RRB- en-wikipedia-org-9224 403 14 . . . en-wikipedia-org-9224 404 1 " " `` en-wikipedia-org-9224 404 2 Prostatic prostatic JJ en-wikipedia-org-9224 404 3 antibacterial antibacterial JJ en-wikipedia-org-9224 404 4 factor factor NN en-wikipedia-org-9224 404 5 . . . en-wikipedia-org-9224 405 1 Identity identity NN en-wikipedia-org-9224 405 2 and and CC en-wikipedia-org-9224 405 3 significance significance NN en-wikipedia-org-9224 405 4 " " '' en-wikipedia-org-9224 405 5 . . . en-wikipedia-org-9224 406 1 Urology urology NN en-wikipedia-org-9224 406 2 . . . en-wikipedia-org-9224 407 1 7 7 CD en-wikipedia-org-9224 407 2 ( ( -LRB- en-wikipedia-org-9224 407 3 2 2 CD en-wikipedia-org-9224 407 4 ) ) -RRB- en-wikipedia-org-9224 407 5 : : : en-wikipedia-org-9224 407 6 169–77 169–77 CD en-wikipedia-org-9224 407 7 . . . en-wikipedia-org-9224 408 1 doi:10.1016/0090 doi:10.1016/0090 NNP en-wikipedia-org-9224 408 2 - - HYPH en-wikipedia-org-9224 408 3 4295(76)90305 4295(76)90305 NNP en-wikipedia-org-9224 408 4 - - HYPH en-wikipedia-org-9224 408 5 8 8 CD en-wikipedia-org-9224 408 6 . . . en-wikipedia-org-9224 409 1 PMID PMID NNP en-wikipedia-org-9224 409 2   _SP en-wikipedia-org-9224 409 3 54972 54972 CD en-wikipedia-org-9224 409 4 . . . en-wikipedia-org-9224 410 1 ^ ^ NNP en-wikipedia-org-9224 410 2 Yenugu Yenugu NNP en-wikipedia-org-9224 410 3 S S NNP en-wikipedia-org-9224 410 4 , , , en-wikipedia-org-9224 410 5 Hamil Hamil NNP en-wikipedia-org-9224 410 6 KG KG NNP en-wikipedia-org-9224 410 7 , , , en-wikipedia-org-9224 410 8 Birse Birse NNP en-wikipedia-org-9224 410 9 CE CE NNP en-wikipedia-org-9224 410 10 , , , en-wikipedia-org-9224 410 11 Ruben Ruben NNP en-wikipedia-org-9224 410 12 SM SM NNP en-wikipedia-org-9224 410 13 , , , en-wikipedia-org-9224 410 14 French French NNP en-wikipedia-org-9224 410 15 FS FS NNP en-wikipedia-org-9224 410 16 , , , en-wikipedia-org-9224 410 17 Hall Hall NNP en-wikipedia-org-9224 410 18 SH SH NNP en-wikipedia-org-9224 410 19 ( ( -LRB- en-wikipedia-org-9224 410 20 June June NNP en-wikipedia-org-9224 410 21 2003 2003 CD en-wikipedia-org-9224 410 22 ) ) -RRB- en-wikipedia-org-9224 410 23 . . . en-wikipedia-org-9224 411 1 " " `` en-wikipedia-org-9224 411 2 Antibacterial antibacterial JJ en-wikipedia-org-9224 411 3 properties property NNS en-wikipedia-org-9224 411 4 of of IN en-wikipedia-org-9224 411 5 the the DT en-wikipedia-org-9224 411 6 sperm sperm RB en-wikipedia-org-9224 411 7 - - HYPH en-wikipedia-org-9224 411 8 binding bind VBG en-wikipedia-org-9224 411 9 proteins protein NNS en-wikipedia-org-9224 411 10 and and CC en-wikipedia-org-9224 411 11 peptides peptide NNS en-wikipedia-org-9224 411 12 of of IN en-wikipedia-org-9224 411 13 human human JJ en-wikipedia-org-9224 411 14 epididymis epididymis NNP en-wikipedia-org-9224 411 15 2 2 CD en-wikipedia-org-9224 411 16 ( ( -LRB- en-wikipedia-org-9224 411 17 HE2 HE2 NNP en-wikipedia-org-9224 411 18 ) ) -RRB- en-wikipedia-org-9224 411 19 family family NN en-wikipedia-org-9224 411 20 ; ; : en-wikipedia-org-9224 411 21 salt salt NN en-wikipedia-org-9224 411 22 sensitivity sensitivity NN en-wikipedia-org-9224 411 23 , , , en-wikipedia-org-9224 411 24 structural structural JJ en-wikipedia-org-9224 411 25 dependence dependence NN en-wikipedia-org-9224 411 26 and and CC en-wikipedia-org-9224 411 27 their -PRON- PRP$ en-wikipedia-org-9224 411 28 interaction interaction NN en-wikipedia-org-9224 411 29 with with IN en-wikipedia-org-9224 411 30 outer outer JJ en-wikipedia-org-9224 411 31 and and CC en-wikipedia-org-9224 411 32 cytoplasmic cytoplasmic JJ en-wikipedia-org-9224 411 33 membranes membrane NNS en-wikipedia-org-9224 411 34 of of IN en-wikipedia-org-9224 411 35 Escherichia Escherichia NNP en-wikipedia-org-9224 411 36 coli coli NNS en-wikipedia-org-9224 411 37 " " '' en-wikipedia-org-9224 411 38 . . . en-wikipedia-org-9224 412 1 The the DT en-wikipedia-org-9224 412 2 Biochemical Biochemical NNP en-wikipedia-org-9224 412 3 Journal Journal NNP en-wikipedia-org-9224 412 4 . . . en-wikipedia-org-9224 413 1 372 372 CD en-wikipedia-org-9224 413 2 ( ( -LRB- en-wikipedia-org-9224 413 3 Pt Pt NNP en-wikipedia-org-9224 413 4 2 2 CD en-wikipedia-org-9224 413 5 ) ) -RRB- en-wikipedia-org-9224 413 6 : : : en-wikipedia-org-9224 413 7 473–83 473–83 CD en-wikipedia-org-9224 413 8 . . . en-wikipedia-org-9224 414 1 doi:10.1042 doi:10.1042 LS en-wikipedia-org-9224 414 2 / / SYM en-wikipedia-org-9224 414 3 BJ20030225 bj20030225 UH en-wikipedia-org-9224 414 4 . . . en-wikipedia-org-9224 415 1 PMC PMC NNP en-wikipedia-org-9224 415 2   _SP en-wikipedia-org-9224 415 3 1223422 1223422 CD en-wikipedia-org-9224 415 4 . . . en-wikipedia-org-9224 416 1 PMID PMID NNP en-wikipedia-org-9224 416 2   _SP en-wikipedia-org-9224 416 3 12628001 12628001 CD en-wikipedia-org-9224 416 4 . . . en-wikipedia-org-9224 417 1 ^ ^ NN en-wikipedia-org-9224 417 2 Smith Smith NNP en-wikipedia-org-9224 417 3 JL JL NNP en-wikipedia-org-9224 417 4 ( ( -LRB- en-wikipedia-org-9224 417 5 2003 2003 CD en-wikipedia-org-9224 417 6 ) ) -RRB- en-wikipedia-org-9224 417 7 . . . en-wikipedia-org-9224 418 1 " " `` en-wikipedia-org-9224 418 2 The the DT en-wikipedia-org-9224 418 3 role role NN en-wikipedia-org-9224 418 4 of of IN en-wikipedia-org-9224 418 5 gastric gastric JJ en-wikipedia-org-9224 418 6 acid acid NN en-wikipedia-org-9224 418 7 in in IN en-wikipedia-org-9224 418 8 preventing prevent VBG en-wikipedia-org-9224 418 9 foodborne foodborne JJ en-wikipedia-org-9224 418 10 disease disease NN en-wikipedia-org-9224 418 11 and and CC en-wikipedia-org-9224 418 12 how how WRB en-wikipedia-org-9224 418 13 bacteria bacteria NNS en-wikipedia-org-9224 418 14 overcome overcome VBP en-wikipedia-org-9224 418 15 acid acid JJ en-wikipedia-org-9224 418 16 conditions condition NNS en-wikipedia-org-9224 418 17 " " '' en-wikipedia-org-9224 418 18 . . . en-wikipedia-org-9224 419 1 J J NNP en-wikipedia-org-9224 419 2 Food Food NNP en-wikipedia-org-9224 419 3 Prot Prot NNP en-wikipedia-org-9224 419 4 . . . en-wikipedia-org-9224 420 1 66 66 CD en-wikipedia-org-9224 420 2 ( ( -LRB- en-wikipedia-org-9224 420 3 7 7 CD en-wikipedia-org-9224 420 4 ) ) -RRB- en-wikipedia-org-9224 420 5 : : : en-wikipedia-org-9224 420 6 1292–1303 1292–1303 CD en-wikipedia-org-9224 420 7 . . . en-wikipedia-org-9224 421 1 doi:10.4315/0362 doi:10.4315/0362 NNP en-wikipedia-org-9224 421 2 - - HYPH en-wikipedia-org-9224 421 3 028X-66.7.1292 028X-66.7.1292 NNP en-wikipedia-org-9224 421 4 . . . en-wikipedia-org-9224 422 1 PMID PMID NNP en-wikipedia-org-9224 422 2   _SP en-wikipedia-org-9224 422 3 12870767 12870767 CD en-wikipedia-org-9224 422 4 . . . en-wikipedia-org-9224 423 1 ^ ^ NNP en-wikipedia-org-9224 423 2 Gorbach Gorbach NNP en-wikipedia-org-9224 423 3 SL SL NNP en-wikipedia-org-9224 423 4 ( ( -LRB- en-wikipedia-org-9224 423 5 February February NNP en-wikipedia-org-9224 423 6 1990 1990 CD en-wikipedia-org-9224 423 7 ) ) -RRB- en-wikipedia-org-9224 423 8 . . . en-wikipedia-org-9224 424 1 " " `` en-wikipedia-org-9224 424 2 Lactic lactic JJ en-wikipedia-org-9224 424 3 acid acid NN en-wikipedia-org-9224 424 4 bacteria bacteria NNS en-wikipedia-org-9224 424 5 and and CC en-wikipedia-org-9224 424 6 human human JJ en-wikipedia-org-9224 424 7 health health NN en-wikipedia-org-9224 424 8 " " '' en-wikipedia-org-9224 424 9 . . . en-wikipedia-org-9224 425 1 Annals Annals NNP en-wikipedia-org-9224 425 2 of of IN en-wikipedia-org-9224 425 3 Medicine Medicine NNP en-wikipedia-org-9224 425 4 . . . en-wikipedia-org-9224 426 1 22 22 CD en-wikipedia-org-9224 426 2 ( ( -LRB- en-wikipedia-org-9224 426 3 1 1 CD en-wikipedia-org-9224 426 4 ) ) -RRB- en-wikipedia-org-9224 426 5 : : : en-wikipedia-org-9224 426 6 37–41 37–41 CD en-wikipedia-org-9224 426 7 . . . en-wikipedia-org-9224 427 1 doi:10.3109/07853899009147239 doi:10.3109/07853899009147239 NNP en-wikipedia-org-9224 427 2 . . . en-wikipedia-org-9224 428 1 PMID PMID NNP en-wikipedia-org-9224 428 2   _SP en-wikipedia-org-9224 428 3 2109988 2109988 CD en-wikipedia-org-9224 428 4 . . . en-wikipedia-org-9224 429 1 ^ ^ NFP en-wikipedia-org-9224 429 2 Medzhitov Medzhitov NNP en-wikipedia-org-9224 429 3 R R NNP en-wikipedia-org-9224 429 4 ( ( -LRB- en-wikipedia-org-9224 429 5 October October NNP en-wikipedia-org-9224 429 6 2007 2007 CD en-wikipedia-org-9224 429 7 ) ) -RRB- en-wikipedia-org-9224 429 8 . . . en-wikipedia-org-9224 430 1 " " `` en-wikipedia-org-9224 430 2 Recognition recognition NN en-wikipedia-org-9224 430 3 of of IN en-wikipedia-org-9224 430 4 microorganisms microorganism NNS en-wikipedia-org-9224 430 5 and and CC en-wikipedia-org-9224 430 6 activation activation NN en-wikipedia-org-9224 430 7 of of IN en-wikipedia-org-9224 430 8 the the DT en-wikipedia-org-9224 430 9 immune immune JJ en-wikipedia-org-9224 430 10 response response NN en-wikipedia-org-9224 430 11 " " '' en-wikipedia-org-9224 430 12 . . . en-wikipedia-org-9224 431 1 Nature nature NN en-wikipedia-org-9224 431 2 . . . en-wikipedia-org-9224 432 1 449 449 CD en-wikipedia-org-9224 432 2 ( ( -LRB- en-wikipedia-org-9224 432 3 7164 7164 CD en-wikipedia-org-9224 432 4 ) ) -RRB- en-wikipedia-org-9224 432 5 : : : en-wikipedia-org-9224 432 6 819–26 819–26 CD en-wikipedia-org-9224 432 7 . . . en-wikipedia-org-9224 433 1 Bibcode:2007Natur.449 bibcode:2007natur.449 LS en-wikipedia-org-9224 433 2 .. .. NFP en-wikipedia-org-9224 433 3 819M. 819m. CD en-wikipedia-org-9224 434 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 434 2 / / SYM en-wikipedia-org-9224 434 3 nature06246 nature06246 NNP en-wikipedia-org-9224 434 4 . . . en-wikipedia-org-9224 435 1 PMID PMID NNP en-wikipedia-org-9224 435 2   _SP en-wikipedia-org-9224 435 3 17943118 17943118 CD en-wikipedia-org-9224 435 4 . . . en-wikipedia-org-9224 436 1 S2CID S2CID NNS en-wikipedia-org-9224 436 2   _SP en-wikipedia-org-9224 436 3 4392839 4392839 CD en-wikipedia-org-9224 436 4 . . . en-wikipedia-org-9224 437 1 ^ ^ NNP en-wikipedia-org-9224 437 2 Matzinger Matzinger NNP en-wikipedia-org-9224 437 3 P P NNP en-wikipedia-org-9224 437 4 ( ( -LRB- en-wikipedia-org-9224 437 5 April April NNP en-wikipedia-org-9224 437 6 2002 2002 CD en-wikipedia-org-9224 437 7 ) ) -RRB- en-wikipedia-org-9224 437 8 . . . en-wikipedia-org-9224 438 1 " " `` en-wikipedia-org-9224 438 2 The the DT en-wikipedia-org-9224 438 3 danger danger NN en-wikipedia-org-9224 438 4 model model NN en-wikipedia-org-9224 438 5 : : : en-wikipedia-org-9224 438 6 a a DT en-wikipedia-org-9224 438 7 renewed renew VBN en-wikipedia-org-9224 438 8 sense sense NN en-wikipedia-org-9224 438 9 of of IN en-wikipedia-org-9224 438 10 self self NN en-wikipedia-org-9224 438 11 " " '' en-wikipedia-org-9224 438 12 ( ( -LRB- en-wikipedia-org-9224 438 13 PDF PDF NNP en-wikipedia-org-9224 438 14 ) ) -RRB- en-wikipedia-org-9224 438 15 . . . en-wikipedia-org-9224 439 1 Science science NN en-wikipedia-org-9224 439 2 . . . en-wikipedia-org-9224 440 1 296 296 CD en-wikipedia-org-9224 440 2 ( ( -LRB- en-wikipedia-org-9224 440 3 5566 5566 CD en-wikipedia-org-9224 440 4 ) ) -RRB- en-wikipedia-org-9224 440 5 : : : en-wikipedia-org-9224 440 6 301–05 301–05 CD en-wikipedia-org-9224 440 7 . . . en-wikipedia-org-9224 441 1 Bibcode:2002Sci Bibcode:2002Sci NNS en-wikipedia-org-9224 441 2 ... ... : en-wikipedia-org-9224 441 3 296 296 CD en-wikipedia-org-9224 441 4 .. .. NFP en-wikipedia-org-9224 441 5 301M. 301m. CD en-wikipedia-org-9224 442 1 doi:10.1126 doi:10.1126 VB en-wikipedia-org-9224 442 2 / / SYM en-wikipedia-org-9224 442 3 science.1071059 science.1071059 NN en-wikipedia-org-9224 442 4 . . . en-wikipedia-org-9224 443 1 PMID PMID NNP en-wikipedia-org-9224 443 2   _SP en-wikipedia-org-9224 443 3 11951032 11951032 CD en-wikipedia-org-9224 443 4 . . . en-wikipedia-org-9224 444 1 S2CID S2CID NNS en-wikipedia-org-9224 444 2   _SP en-wikipedia-org-9224 444 3 13615808 13615808 CD en-wikipedia-org-9224 444 4 . . . en-wikipedia-org-9224 445 1 ^ ^ NNP en-wikipedia-org-9224 445 2 a a DT en-wikipedia-org-9224 445 3 b b NNP en-wikipedia-org-9224 445 4 Alberts Alberts NNP en-wikipedia-org-9224 445 5 et et NNP en-wikipedia-org-9224 445 6 al al NNP en-wikipedia-org-9224 445 7 . . . en-wikipedia-org-9224 446 1 2002 2002 CD en-wikipedia-org-9224 446 2 , , , en-wikipedia-org-9224 446 3 Chapter chapter NN en-wikipedia-org-9224 446 4 : : : en-wikipedia-org-9224 446 5 " " `` en-wikipedia-org-9224 446 6 Innate innate VB en-wikipedia-org-9224 446 7 Immunity immunity NN en-wikipedia-org-9224 446 8 " " '' en-wikipedia-org-9224 446 9 . . . en-wikipedia-org-9224 447 1 ^ ^ NNP en-wikipedia-org-9224 447 2 Iriti Iriti NNP en-wikipedia-org-9224 447 3 2019 2019 CD en-wikipedia-org-9224 447 4 , , , en-wikipedia-org-9224 447 5 p. p. NN en-wikipedia-org-9224 447 6   _SP en-wikipedia-org-9224 447 7 xi xi NNP en-wikipedia-org-9224 447 8 . . . en-wikipedia-org-9224 448 1 ^ ^ NN en-wikipedia-org-9224 448 2 Kumar Kumar NNP en-wikipedia-org-9224 448 3 H H NNP en-wikipedia-org-9224 448 4 , , , en-wikipedia-org-9224 448 5 Kawai Kawai NNP en-wikipedia-org-9224 448 6 T T NNP en-wikipedia-org-9224 448 7 , , , en-wikipedia-org-9224 448 8 Akira Akira NNP en-wikipedia-org-9224 448 9 S S NNP en-wikipedia-org-9224 448 10 ( ( -LRB- en-wikipedia-org-9224 448 11 February February NNP en-wikipedia-org-9224 448 12 2011 2011 CD en-wikipedia-org-9224 448 13 ) ) -RRB- en-wikipedia-org-9224 448 14 . . . en-wikipedia-org-9224 449 1 " " `` en-wikipedia-org-9224 449 2 Pathogen Pathogen NNP en-wikipedia-org-9224 449 3 recognition recognition NN en-wikipedia-org-9224 449 4 by by IN en-wikipedia-org-9224 449 5 the the DT en-wikipedia-org-9224 449 6 innate innate JJ en-wikipedia-org-9224 449 7 immune immune JJ en-wikipedia-org-9224 449 8 system system NN en-wikipedia-org-9224 449 9 " " '' en-wikipedia-org-9224 449 10 . . . en-wikipedia-org-9224 450 1 International International NNP en-wikipedia-org-9224 450 2 Reviews Reviews NNPS en-wikipedia-org-9224 450 3 of of IN en-wikipedia-org-9224 450 4 Immunology Immunology NNP en-wikipedia-org-9224 450 5 . . . en-wikipedia-org-9224 451 1 30 30 CD en-wikipedia-org-9224 451 2 ( ( -LRB- en-wikipedia-org-9224 451 3 1 1 CD en-wikipedia-org-9224 451 4 ) ) -RRB- en-wikipedia-org-9224 451 5 : : : en-wikipedia-org-9224 451 6 16–34 16–34 CD en-wikipedia-org-9224 451 7 . . . en-wikipedia-org-9224 452 1 doi:10.3109/08830185.2010.529976 doi:10.3109/08830185.2010.529976 NNP en-wikipedia-org-9224 452 2 . . . en-wikipedia-org-9224 453 1 PMID PMID NNP en-wikipedia-org-9224 453 2   _SP en-wikipedia-org-9224 453 3 21235323 21235323 CD en-wikipedia-org-9224 453 4 . . . en-wikipedia-org-9224 454 1 S2CID S2CID NNS en-wikipedia-org-9224 454 2   _SP en-wikipedia-org-9224 454 3 42000671 42000671 CD en-wikipedia-org-9224 454 4 . . . en-wikipedia-org-9224 455 1 ^ ^ NFP en-wikipedia-org-9224 455 2 Schroder Schroder NNP en-wikipedia-org-9224 455 3 K K NNP en-wikipedia-org-9224 455 4 , , , en-wikipedia-org-9224 455 5 Tschopp Tschopp NNP en-wikipedia-org-9224 455 6 J J NNP en-wikipedia-org-9224 455 7 ( ( -LRB- en-wikipedia-org-9224 455 8 March March NNP en-wikipedia-org-9224 455 9 2010 2010 CD en-wikipedia-org-9224 455 10 ) ) -RRB- en-wikipedia-org-9224 455 11 . . . en-wikipedia-org-9224 456 1 " " `` en-wikipedia-org-9224 456 2 The the DT en-wikipedia-org-9224 456 3 inflammasomes inflammasome NNS en-wikipedia-org-9224 456 4 " " '' en-wikipedia-org-9224 456 5 . . . en-wikipedia-org-9224 457 1 Cell cell NN en-wikipedia-org-9224 457 2 . . . en-wikipedia-org-9224 458 1 140 140 CD en-wikipedia-org-9224 458 2 ( ( -LRB- en-wikipedia-org-9224 458 3 6 6 CD en-wikipedia-org-9224 458 4 ) ) -RRB- en-wikipedia-org-9224 458 5 : : : en-wikipedia-org-9224 458 6 821–32 821–32 CD en-wikipedia-org-9224 458 7 . . . en-wikipedia-org-9224 459 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 459 2 / / SYM en-wikipedia-org-9224 459 3 j.cell.2010.01.040 j.cell.2010.01.040 CD en-wikipedia-org-9224 459 4 . . . en-wikipedia-org-9224 460 1 PMID PMID NNP en-wikipedia-org-9224 460 2   _SP en-wikipedia-org-9224 460 3 20303873 20303873 CD en-wikipedia-org-9224 460 4 . . . en-wikipedia-org-9224 461 1 S2CID S2CID NNS en-wikipedia-org-9224 461 2   _SP en-wikipedia-org-9224 461 3 16916572 16916572 CD en-wikipedia-org-9224 461 4 . . . en-wikipedia-org-9224 462 1 ^ ^ NNP en-wikipedia-org-9224 462 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 462 3 2019 2019 CD en-wikipedia-org-9224 462 4 , , , en-wikipedia-org-9224 462 5 p. p. NN en-wikipedia-org-9224 462 6   _SP en-wikipedia-org-9224 462 7 20 20 CD en-wikipedia-org-9224 462 8 . . . en-wikipedia-org-9224 463 1 ^ ^ NNP en-wikipedia-org-9224 463 2 Beutler Beutler NNP en-wikipedia-org-9224 463 3 B B NNP en-wikipedia-org-9224 463 4 , , , en-wikipedia-org-9224 463 5 Jiang Jiang NNP en-wikipedia-org-9224 463 6 Z Z NNP en-wikipedia-org-9224 463 7 , , , en-wikipedia-org-9224 463 8 Georgel Georgel NNP en-wikipedia-org-9224 463 9 P P NNP en-wikipedia-org-9224 463 10 , , , en-wikipedia-org-9224 463 11 Crozat Crozat NNP en-wikipedia-org-9224 463 12 K K NNP en-wikipedia-org-9224 463 13 , , , en-wikipedia-org-9224 463 14 Croker Croker NNP en-wikipedia-org-9224 463 15 B B NNP en-wikipedia-org-9224 463 16 , , , en-wikipedia-org-9224 463 17 Rutschmann Rutschmann NNP en-wikipedia-org-9224 463 18 S S NNP en-wikipedia-org-9224 463 19 , , , en-wikipedia-org-9224 463 20 Du Du NNP en-wikipedia-org-9224 463 21 X X NNP en-wikipedia-org-9224 463 22 , , , en-wikipedia-org-9224 463 23 Hoebe Hoebe NNP en-wikipedia-org-9224 463 24 K K NNP en-wikipedia-org-9224 463 25 ( ( -LRB- en-wikipedia-org-9224 463 26 2006 2006 CD en-wikipedia-org-9224 463 27 ) ) -RRB- en-wikipedia-org-9224 463 28 . . . en-wikipedia-org-9224 464 1 " " `` en-wikipedia-org-9224 464 2 Genetic genetic JJ en-wikipedia-org-9224 464 3 analysis analysis NN en-wikipedia-org-9224 464 4 of of IN en-wikipedia-org-9224 464 5 host host NN en-wikipedia-org-9224 464 6 resistance resistance NN en-wikipedia-org-9224 464 7 : : : en-wikipedia-org-9224 464 8 Toll toll NN en-wikipedia-org-9224 464 9 - - HYPH en-wikipedia-org-9224 464 10 like like JJ en-wikipedia-org-9224 464 11 receptor receptor NN en-wikipedia-org-9224 464 12 signaling signaling NN en-wikipedia-org-9224 464 13 and and CC en-wikipedia-org-9224 464 14 immunity immunity NN en-wikipedia-org-9224 464 15 at at IN en-wikipedia-org-9224 464 16 large large JJ en-wikipedia-org-9224 464 17 " " '' en-wikipedia-org-9224 464 18 . . . en-wikipedia-org-9224 465 1 Annual Annual NNP en-wikipedia-org-9224 465 2 Review Review NNP en-wikipedia-org-9224 465 3 of of IN en-wikipedia-org-9224 465 4 Immunology Immunology NNP en-wikipedia-org-9224 465 5 . . . en-wikipedia-org-9224 466 1 24 24 CD en-wikipedia-org-9224 466 2 : : SYM en-wikipedia-org-9224 466 3 353–89 353–89 CD en-wikipedia-org-9224 466 4 . . . en-wikipedia-org-9224 467 1 doi:10.1146 doi:10.1146 NNP en-wikipedia-org-9224 467 2 / / SYM en-wikipedia-org-9224 467 3 annurev.immunol.24.021605.090552 annurev.immunol.24.021605.090552 NNP en-wikipedia-org-9224 467 4 . . . en-wikipedia-org-9224 468 1 PMID PMID NNP en-wikipedia-org-9224 468 2   _SP en-wikipedia-org-9224 468 3 16551253 16551253 CD en-wikipedia-org-9224 468 4 . . . en-wikipedia-org-9224 469 1 S2CID S2CID NNS en-wikipedia-org-9224 469 2   _SP en-wikipedia-org-9224 469 3 20991617 20991617 CD en-wikipedia-org-9224 469 4 . . . en-wikipedia-org-9224 470 1 ^ ^ NFP en-wikipedia-org-9224 470 2 Botos Botos NNP en-wikipedia-org-9224 470 3 I I NNP en-wikipedia-org-9224 470 4 , , , en-wikipedia-org-9224 470 5 Segal Segal NNP en-wikipedia-org-9224 470 6 DM DM NNP en-wikipedia-org-9224 470 7 , , , en-wikipedia-org-9224 470 8 Davies Davies NNP en-wikipedia-org-9224 470 9 DR DR NNP en-wikipedia-org-9224 470 10 ( ( -LRB- en-wikipedia-org-9224 470 11 April April NNP en-wikipedia-org-9224 470 12 2011 2011 CD en-wikipedia-org-9224 470 13 ) ) -RRB- en-wikipedia-org-9224 470 14 . . . en-wikipedia-org-9224 471 1 " " `` en-wikipedia-org-9224 471 2 The the DT en-wikipedia-org-9224 471 3 structural structural JJ en-wikipedia-org-9224 471 4 biology biology NN en-wikipedia-org-9224 471 5 of of IN en-wikipedia-org-9224 471 6 Toll Toll NNP en-wikipedia-org-9224 471 7 - - HYPH en-wikipedia-org-9224 471 8 like like JJ en-wikipedia-org-9224 471 9 receptors receptor NNS en-wikipedia-org-9224 471 10 " " '' en-wikipedia-org-9224 471 11 . . . en-wikipedia-org-9224 472 1 Structure structure NN en-wikipedia-org-9224 472 2 . . . en-wikipedia-org-9224 473 1 19 19 CD en-wikipedia-org-9224 473 2 ( ( -LRB- en-wikipedia-org-9224 473 3 4 4 CD en-wikipedia-org-9224 473 4 ) ) -RRB- en-wikipedia-org-9224 473 5 : : : en-wikipedia-org-9224 473 6 447–59 447–59 CD en-wikipedia-org-9224 473 7 . . . en-wikipedia-org-9224 474 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 474 2 / / SYM en-wikipedia-org-9224 474 3 j.str.2011.02.004 j.str.2011.02.004 NNP en-wikipedia-org-9224 474 4 . . . en-wikipedia-org-9224 475 1 PMC PMC NNP en-wikipedia-org-9224 475 2   _SP en-wikipedia-org-9224 475 3 3075535 3075535 CD en-wikipedia-org-9224 475 4 . . . en-wikipedia-org-9224 476 1 PMID PMID NNP en-wikipedia-org-9224 476 2   _SP en-wikipedia-org-9224 476 3 21481769 21481769 CD en-wikipedia-org-9224 476 4 . . . en-wikipedia-org-9224 477 1 ^ ^ NNP en-wikipedia-org-9224 477 2 Vijay Vijay NNP en-wikipedia-org-9224 477 3 K K NNP en-wikipedia-org-9224 477 4 ( ( -LRB- en-wikipedia-org-9224 477 5 June June NNP en-wikipedia-org-9224 477 6 2018 2018 CD en-wikipedia-org-9224 477 7 ) ) -RRB- en-wikipedia-org-9224 477 8 . . . en-wikipedia-org-9224 478 1 " " `` en-wikipedia-org-9224 478 2 Toll toll NN en-wikipedia-org-9224 478 3 - - HYPH en-wikipedia-org-9224 478 4 like like JJ en-wikipedia-org-9224 478 5 receptors receptor NNS en-wikipedia-org-9224 478 6 in in IN en-wikipedia-org-9224 478 7 immunity immunity NN en-wikipedia-org-9224 478 8 and and CC en-wikipedia-org-9224 478 9 inflammatory inflammatory JJ en-wikipedia-org-9224 478 10 diseases disease NNS en-wikipedia-org-9224 478 11 : : : en-wikipedia-org-9224 478 12 Past past NN en-wikipedia-org-9224 478 13 , , , en-wikipedia-org-9224 478 14 present present JJ en-wikipedia-org-9224 478 15 , , , en-wikipedia-org-9224 478 16 and and CC en-wikipedia-org-9224 478 17 future future JJ en-wikipedia-org-9224 478 18 " " '' en-wikipedia-org-9224 478 19 . . . en-wikipedia-org-9224 479 1 Int Int NNP en-wikipedia-org-9224 479 2 Immunopharmacol Immunopharmacol NNP en-wikipedia-org-9224 479 3 . . . en-wikipedia-org-9224 480 1 59 59 CD en-wikipedia-org-9224 480 2 : : : en-wikipedia-org-9224 480 3 391–412 391–412 CD en-wikipedia-org-9224 480 4 . . . en-wikipedia-org-9224 481 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 481 2 / / SYM en-wikipedia-org-9224 481 3 j.intimp.2018.03.002 j.intimp.2018.03.002 NNP en-wikipedia-org-9224 481 4 . . . en-wikipedia-org-9224 482 1 PMC PMC NNP en-wikipedia-org-9224 482 2   _SP en-wikipedia-org-9224 482 3 7106078 7106078 CD en-wikipedia-org-9224 482 4 . . . en-wikipedia-org-9224 483 1 PMID PMID NNP en-wikipedia-org-9224 483 2   _SP en-wikipedia-org-9224 483 3 29730580 29730580 CD en-wikipedia-org-9224 483 4 . . . en-wikipedia-org-9224 484 1 ^ ^ NNP en-wikipedia-org-9224 484 2 Thompson Thompson NNP en-wikipedia-org-9224 484 3 MR MR NNP en-wikipedia-org-9224 484 4 , , , en-wikipedia-org-9224 484 5 Kaminski Kaminski NNP en-wikipedia-org-9224 484 6 JJ JJ NNP en-wikipedia-org-9224 484 7 , , , en-wikipedia-org-9224 484 8 Kurt Kurt NNP en-wikipedia-org-9224 484 9 - - HYPH en-wikipedia-org-9224 484 10 Jones Jones NNP en-wikipedia-org-9224 484 11 EA EA NNP en-wikipedia-org-9224 484 12 , , , en-wikipedia-org-9224 484 13 Fitzgerald Fitzgerald NNP en-wikipedia-org-9224 484 14 KA KA NNP en-wikipedia-org-9224 484 15 ( ( -LRB- en-wikipedia-org-9224 484 16 June June NNP en-wikipedia-org-9224 484 17 2011 2011 CD en-wikipedia-org-9224 484 18 ) ) -RRB- en-wikipedia-org-9224 484 19 . . . en-wikipedia-org-9224 485 1 " " `` en-wikipedia-org-9224 485 2 Pattern pattern NN en-wikipedia-org-9224 485 3 recognition recognition NN en-wikipedia-org-9224 485 4 receptors receptor NNS en-wikipedia-org-9224 485 5 and and CC en-wikipedia-org-9224 485 6 the the DT en-wikipedia-org-9224 485 7 innate innate JJ en-wikipedia-org-9224 485 8 immune immune JJ en-wikipedia-org-9224 485 9 response response NN en-wikipedia-org-9224 485 10 to to IN en-wikipedia-org-9224 485 11 viral viral JJ en-wikipedia-org-9224 485 12 infection infection NN en-wikipedia-org-9224 485 13 " " '' en-wikipedia-org-9224 485 14 . . . en-wikipedia-org-9224 486 1 Viruses virus NNS en-wikipedia-org-9224 486 2 . . . en-wikipedia-org-9224 487 1 3 3 CD en-wikipedia-org-9224 487 2 ( ( -LRB- en-wikipedia-org-9224 487 3 6 6 CD en-wikipedia-org-9224 487 4 ) ) -RRB- en-wikipedia-org-9224 487 5 : : : en-wikipedia-org-9224 487 6 920–40 920–40 CD en-wikipedia-org-9224 487 7 . . . en-wikipedia-org-9224 488 1 doi:10.3390 doi:10.3390 NNP en-wikipedia-org-9224 488 2 / / SYM en-wikipedia-org-9224 488 3 v3060920 v3060920 NNP en-wikipedia-org-9224 488 4 . . . en-wikipedia-org-9224 489 1 PMC PMC NNP en-wikipedia-org-9224 489 2   _SP en-wikipedia-org-9224 489 3 3186011 3186011 CD en-wikipedia-org-9224 489 4 . . . en-wikipedia-org-9224 490 1 PMID PMID NNP en-wikipedia-org-9224 490 2   _SP en-wikipedia-org-9224 490 3 21994762 21994762 CD en-wikipedia-org-9224 490 4 . . . en-wikipedia-org-9224 491 1 ^ ^ NNP en-wikipedia-org-9224 491 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 491 3 2019 2019 CD en-wikipedia-org-9224 491 4 , , , en-wikipedia-org-9224 491 5 pp pp NNP en-wikipedia-org-9224 491 6 . . . en-wikipedia-org-9224 492 1 1–4 1–4 LS en-wikipedia-org-9224 492 2 . . . en-wikipedia-org-9224 493 1 ^ ^ NNP en-wikipedia-org-9224 493 2 Alberts Alberts NNP en-wikipedia-org-9224 493 3 et et FW en-wikipedia-org-9224 493 4 al al NNP en-wikipedia-org-9224 493 5 . . . en-wikipedia-org-9224 494 1 2002 2002 CD en-wikipedia-org-9224 494 2 , , , en-wikipedia-org-9224 494 3 sec sec NNP en-wikipedia-org-9224 494 4 . . . en-wikipedia-org-9224 495 1 " " `` en-wikipedia-org-9224 495 2 Phagocytic phagocytic JJ en-wikipedia-org-9224 495 3 Cells cell NNS en-wikipedia-org-9224 495 4 Seek seek VBP en-wikipedia-org-9224 495 5 , , , en-wikipedia-org-9224 495 6 Engulf engulf NN en-wikipedia-org-9224 495 7 , , , en-wikipedia-org-9224 495 8 and and CC en-wikipedia-org-9224 495 9 Destroy Destroy NNP en-wikipedia-org-9224 495 10 Pathogens Pathogens NNP en-wikipedia-org-9224 495 11 " " '' en-wikipedia-org-9224 495 12 . . . en-wikipedia-org-9224 496 1 ^ ^ NFP en-wikipedia-org-9224 496 2 Ryter Ryter NNP en-wikipedia-org-9224 496 3 A a NN en-wikipedia-org-9224 496 4 ( ( -LRB- en-wikipedia-org-9224 496 5 1985 1985 CD en-wikipedia-org-9224 496 6 ) ) -RRB- en-wikipedia-org-9224 496 7 . . . en-wikipedia-org-9224 497 1 " " `` en-wikipedia-org-9224 497 2 Relationship relationship NN en-wikipedia-org-9224 497 3 between between IN en-wikipedia-org-9224 497 4 ultrastructure ultrastructure JJ en-wikipedia-org-9224 497 5 and and CC en-wikipedia-org-9224 497 6 specific specific JJ en-wikipedia-org-9224 497 7 functions function NNS en-wikipedia-org-9224 497 8 of of IN en-wikipedia-org-9224 497 9 macrophages macrophage NNS en-wikipedia-org-9224 497 10 " " '' en-wikipedia-org-9224 497 11 . . . en-wikipedia-org-9224 498 1 Comparative comparative JJ en-wikipedia-org-9224 498 2 Immunology Immunology NNP en-wikipedia-org-9224 498 3 , , , en-wikipedia-org-9224 498 4 Microbiology Microbiology NNP en-wikipedia-org-9224 498 5 and and CC en-wikipedia-org-9224 498 6 Infectious Infectious NNP en-wikipedia-org-9224 498 7 Diseases Diseases NNPS en-wikipedia-org-9224 498 8 . . . en-wikipedia-org-9224 499 1 8 8 CD en-wikipedia-org-9224 499 2 ( ( -LRB- en-wikipedia-org-9224 499 3 2 2 CD en-wikipedia-org-9224 499 4 ) ) -RRB- en-wikipedia-org-9224 499 5 : : : en-wikipedia-org-9224 499 6 119–33 119–33 CD en-wikipedia-org-9224 499 7 . . . en-wikipedia-org-9224 500 1 doi:10.1016/0147 doi:10.1016/0147 VB en-wikipedia-org-9224 500 2 - - HYPH en-wikipedia-org-9224 500 3 9571(85)90039 9571(85)90039 NNP en-wikipedia-org-9224 500 4 - - HYPH en-wikipedia-org-9224 500 5 6 6 CD en-wikipedia-org-9224 500 6 . . . en-wikipedia-org-9224 501 1 PMID PMID NNP en-wikipedia-org-9224 501 2   _SP en-wikipedia-org-9224 501 3 3910340 3910340 CD en-wikipedia-org-9224 501 4 . . . en-wikipedia-org-9224 502 1 ^ ^ NFP en-wikipedia-org-9224 502 2 Langermans Langermans NNPS en-wikipedia-org-9224 502 3 JA JA NNP en-wikipedia-org-9224 502 4 , , , en-wikipedia-org-9224 502 5 Hazenbos Hazenbos NNP en-wikipedia-org-9224 502 6 WL WL NNP en-wikipedia-org-9224 502 7 , , , en-wikipedia-org-9224 502 8 van van NNP en-wikipedia-org-9224 502 9 Furth Furth NNP en-wikipedia-org-9224 502 10 R R NNP en-wikipedia-org-9224 502 11 ( ( -LRB- en-wikipedia-org-9224 502 12 September September NNP en-wikipedia-org-9224 502 13 1994 1994 CD en-wikipedia-org-9224 502 14 ) ) -RRB- en-wikipedia-org-9224 502 15 . . . en-wikipedia-org-9224 503 1 " " `` en-wikipedia-org-9224 503 2 Antimicrobial antimicrobial JJ en-wikipedia-org-9224 503 3 functions function NNS en-wikipedia-org-9224 503 4 of of IN en-wikipedia-org-9224 503 5 mononuclear mononuclear NN en-wikipedia-org-9224 503 6 phagocytes phagocyte NNS en-wikipedia-org-9224 503 7 " " '' en-wikipedia-org-9224 503 8 . . . en-wikipedia-org-9224 504 1 Journal Journal NNP en-wikipedia-org-9224 504 2 of of IN en-wikipedia-org-9224 504 3 Immunological Immunological NNP en-wikipedia-org-9224 504 4 Methods Methods NNPS en-wikipedia-org-9224 504 5 . . . en-wikipedia-org-9224 505 1 174 174 CD en-wikipedia-org-9224 505 2 ( ( -LRB- en-wikipedia-org-9224 505 3 1–2 1–2 CD en-wikipedia-org-9224 505 4 ) ) -RRB- en-wikipedia-org-9224 505 5 : : : en-wikipedia-org-9224 505 6 185–94 185–94 CD en-wikipedia-org-9224 505 7 . . . en-wikipedia-org-9224 506 1 doi:10.1016/0022 doi:10.1016/0022 NNP en-wikipedia-org-9224 506 2 - - HYPH en-wikipedia-org-9224 506 3 1759(94)90021 1759(94)90021 NNP en-wikipedia-org-9224 506 4 - - HYPH en-wikipedia-org-9224 506 5 3 3 CD en-wikipedia-org-9224 506 6 . . . en-wikipedia-org-9224 507 1 PMID PMID NNP en-wikipedia-org-9224 507 2   _SP en-wikipedia-org-9224 507 3 8083520 8083520 CD en-wikipedia-org-9224 507 4 . . . en-wikipedia-org-9224 508 1 ^ ^ NN en-wikipedia-org-9224 508 2 May May NNP en-wikipedia-org-9224 508 3 RC rc VB en-wikipedia-org-9224 508 4 , , , en-wikipedia-org-9224 508 5 Machesky Machesky NNP en-wikipedia-org-9224 508 6 LM LM NNP en-wikipedia-org-9224 508 7 ( ( -LRB- en-wikipedia-org-9224 508 8 March March NNP en-wikipedia-org-9224 508 9 2001 2001 CD en-wikipedia-org-9224 508 10 ) ) -RRB- en-wikipedia-org-9224 508 11 . . . en-wikipedia-org-9224 509 1 " " `` en-wikipedia-org-9224 509 2 Phagocytosis Phagocytosis NNP en-wikipedia-org-9224 509 3 and and CC en-wikipedia-org-9224 509 4 the the DT en-wikipedia-org-9224 509 5 actin actin NNP en-wikipedia-org-9224 509 6 cytoskeleton cytoskeleton NN en-wikipedia-org-9224 509 7 " " '' en-wikipedia-org-9224 509 8 . . . en-wikipedia-org-9224 510 1 Journal Journal NNP en-wikipedia-org-9224 510 2 of of IN en-wikipedia-org-9224 510 3 Cell Cell NNP en-wikipedia-org-9224 510 4 Science Science NNP en-wikipedia-org-9224 510 5 . . . en-wikipedia-org-9224 511 1 114 114 CD en-wikipedia-org-9224 511 2 ( ( -LRB- en-wikipedia-org-9224 511 3 Pt Pt NNP en-wikipedia-org-9224 511 4 6 6 CD en-wikipedia-org-9224 511 5 ) ) -RRB- en-wikipedia-org-9224 511 6 : : : en-wikipedia-org-9224 511 7 1061–77 1061–77 CD en-wikipedia-org-9224 511 8 . . . en-wikipedia-org-9224 512 1 PMID PMID NNP en-wikipedia-org-9224 512 2   _SP en-wikipedia-org-9224 512 3 11228151 11228151 CD en-wikipedia-org-9224 512 4 . . . en-wikipedia-org-9224 513 1 ^ ^ NFP en-wikipedia-org-9224 513 2 Salzet Salzet NNP en-wikipedia-org-9224 513 3 M M NNP en-wikipedia-org-9224 513 4 , , , en-wikipedia-org-9224 513 5 Tasiemski Tasiemski NNP en-wikipedia-org-9224 513 6 A A NNP en-wikipedia-org-9224 513 7 , , , en-wikipedia-org-9224 513 8 Cooper Cooper NNP en-wikipedia-org-9224 513 9 E e NN en-wikipedia-org-9224 513 10 ( ( -LRB- en-wikipedia-org-9224 513 11 2006 2006 CD en-wikipedia-org-9224 513 12 ) ) -RRB- en-wikipedia-org-9224 513 13 . . . en-wikipedia-org-9224 514 1 " " `` en-wikipedia-org-9224 514 2 Innate innate VB en-wikipedia-org-9224 514 3 immunity immunity NN en-wikipedia-org-9224 514 4 in in IN en-wikipedia-org-9224 514 5 lophotrochozoans lophotrochozoan NNS en-wikipedia-org-9224 514 6 : : : en-wikipedia-org-9224 514 7 the the DT en-wikipedia-org-9224 514 8 annelids annelid NNS en-wikipedia-org-9224 514 9 " " '' en-wikipedia-org-9224 514 10 . . . en-wikipedia-org-9224 515 1 Current Current NNP en-wikipedia-org-9224 515 2 Pharmaceutical Pharmaceutical NNP en-wikipedia-org-9224 515 3 Design Design NNP en-wikipedia-org-9224 515 4 . . . en-wikipedia-org-9224 516 1 12 12 CD en-wikipedia-org-9224 516 2 ( ( -LRB- en-wikipedia-org-9224 516 3 24 24 CD en-wikipedia-org-9224 516 4 ) ) -RRB- en-wikipedia-org-9224 516 5 : : : en-wikipedia-org-9224 516 6 3043–50 3043–50 LS en-wikipedia-org-9224 516 7 . . . en-wikipedia-org-9224 517 1 doi:10.2174/138161206777947551 doi:10.2174/138161206777947551 NNP en-wikipedia-org-9224 517 2 . . . en-wikipedia-org-9224 518 1 PMID PMID NNP en-wikipedia-org-9224 518 2   _SP en-wikipedia-org-9224 518 3 16918433 16918433 CD en-wikipedia-org-9224 518 4 . . . en-wikipedia-org-9224 519 1 S2CID S2CID NNS en-wikipedia-org-9224 519 2   _SP en-wikipedia-org-9224 519 3 28520695 28520695 CD en-wikipedia-org-9224 519 4 . . . en-wikipedia-org-9224 520 1 ^ ^ NNP en-wikipedia-org-9224 520 2 Zen Zen NNP en-wikipedia-org-9224 520 3 K K NNP en-wikipedia-org-9224 520 4 , , , en-wikipedia-org-9224 520 5 Parkos Parkos NNP en-wikipedia-org-9224 520 6 CA CA NNP en-wikipedia-org-9224 520 7 ( ( -LRB- en-wikipedia-org-9224 520 8 October October NNP en-wikipedia-org-9224 520 9 2003 2003 CD en-wikipedia-org-9224 520 10 ) ) -RRB- en-wikipedia-org-9224 520 11 . . . en-wikipedia-org-9224 521 1 " " `` en-wikipedia-org-9224 521 2 Leukocyte Leukocyte NNP en-wikipedia-org-9224 521 3 - - HYPH en-wikipedia-org-9224 521 4 epithelial epithelial JJ en-wikipedia-org-9224 521 5 interactions interaction NNS en-wikipedia-org-9224 521 6 " " '' en-wikipedia-org-9224 521 7 . . . en-wikipedia-org-9224 522 1 Current current JJ en-wikipedia-org-9224 522 2 Opinion opinion NN en-wikipedia-org-9224 522 3 in in IN en-wikipedia-org-9224 522 4 Cell Cell NNP en-wikipedia-org-9224 522 5 Biology Biology NNP en-wikipedia-org-9224 522 6 . . . en-wikipedia-org-9224 523 1 15 15 CD en-wikipedia-org-9224 523 2 ( ( -LRB- en-wikipedia-org-9224 523 3 5 5 CD en-wikipedia-org-9224 523 4 ) ) -RRB- en-wikipedia-org-9224 523 5 : : : en-wikipedia-org-9224 523 6 557–64 557–64 CD en-wikipedia-org-9224 523 7 . . . en-wikipedia-org-9224 524 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 524 2 / / SYM en-wikipedia-org-9224 524 3 S0955 S0955 NNP en-wikipedia-org-9224 524 4 - - HYPH en-wikipedia-org-9224 524 5 0674(03)00103 0674(03)00103 NNP en-wikipedia-org-9224 524 6 - - HYPH en-wikipedia-org-9224 524 7 0 0 NFP en-wikipedia-org-9224 524 8 . . . en-wikipedia-org-9224 525 1 PMID PMID NNP en-wikipedia-org-9224 525 2   _SP en-wikipedia-org-9224 525 3 14519390 14519390 CD en-wikipedia-org-9224 525 4 . . . en-wikipedia-org-9224 526 1 ^ ^ NNP en-wikipedia-org-9224 526 2 a a DT en-wikipedia-org-9224 526 3 b b NNP en-wikipedia-org-9224 526 4 Stvrtinová Stvrtinová NNP en-wikipedia-org-9224 526 5 , , , en-wikipedia-org-9224 526 6 Jakubovský Jakubovský NNP en-wikipedia-org-9224 526 7 & & CC en-wikipedia-org-9224 526 8 Hulín Hulín NNP en-wikipedia-org-9224 526 9 1995 1995 CD en-wikipedia-org-9224 526 10 , , , en-wikipedia-org-9224 526 11 Chapter chapter NN en-wikipedia-org-9224 526 12 : : : en-wikipedia-org-9224 526 13 Inflammation Inflammation NNP en-wikipedia-org-9224 526 14 and and CC en-wikipedia-org-9224 526 15 Fever Fever NNP en-wikipedia-org-9224 526 16 . . . en-wikipedia-org-9224 527 1 ^ ^ NFP en-wikipedia-org-9224 527 2 Rua Rua NNP en-wikipedia-org-9224 527 3 R R NNP en-wikipedia-org-9224 527 4 , , , en-wikipedia-org-9224 527 5 McGavern McGavern NNP en-wikipedia-org-9224 527 6 DB DB NNP en-wikipedia-org-9224 527 7 ( ( -LRB- en-wikipedia-org-9224 527 8 September September NNP en-wikipedia-org-9224 527 9 2015 2015 CD en-wikipedia-org-9224 527 10 ) ) -RRB- en-wikipedia-org-9224 527 11 . . . en-wikipedia-org-9224 528 1 " " `` en-wikipedia-org-9224 528 2 Elucidation elucidation NN en-wikipedia-org-9224 528 3 of of IN en-wikipedia-org-9224 528 4 monocyte monocyte NN en-wikipedia-org-9224 528 5 / / SYM en-wikipedia-org-9224 528 6 macrophage macrophage NN en-wikipedia-org-9224 528 7 dynamics dynamic NNS en-wikipedia-org-9224 528 8 and and CC en-wikipedia-org-9224 528 9 function function NN en-wikipedia-org-9224 528 10 by by IN en-wikipedia-org-9224 528 11 intravital intravital JJ en-wikipedia-org-9224 528 12 imaging imaging NN en-wikipedia-org-9224 528 13 " " '' en-wikipedia-org-9224 528 14 . . . en-wikipedia-org-9224 529 1 Journal Journal NNP en-wikipedia-org-9224 529 2 of of IN en-wikipedia-org-9224 529 3 Leukocyte Leukocyte NNP en-wikipedia-org-9224 529 4 Biology Biology NNP en-wikipedia-org-9224 529 5 . . . en-wikipedia-org-9224 530 1 98 98 CD en-wikipedia-org-9224 530 2 ( ( -LRB- en-wikipedia-org-9224 530 3 3 3 CD en-wikipedia-org-9224 530 4 ) ) -RRB- en-wikipedia-org-9224 530 5 : : : en-wikipedia-org-9224 530 6 319–32 319–32 CD en-wikipedia-org-9224 530 7 . . . en-wikipedia-org-9224 531 1 doi:10.1189 doi:10.1189 NNP en-wikipedia-org-9224 531 2 / / SYM en-wikipedia-org-9224 531 3 jlb.4RI0115 jlb.4RI0115 NNP en-wikipedia-org-9224 531 4 - - HYPH en-wikipedia-org-9224 531 5 006RR 006RR NNP en-wikipedia-org-9224 531 6 . . . en-wikipedia-org-9224 532 1 PMC PMC NNP en-wikipedia-org-9224 532 2   _SP en-wikipedia-org-9224 532 3 4763596 4763596 CD en-wikipedia-org-9224 532 4 . . . en-wikipedia-org-9224 533 1 PMID PMID NNP en-wikipedia-org-9224 533 2   _SP en-wikipedia-org-9224 533 3 26162402 26162402 CD en-wikipedia-org-9224 533 4 . . . en-wikipedia-org-9224 534 1 ^ ^ NNP en-wikipedia-org-9224 534 2 a a DT en-wikipedia-org-9224 534 3 b b NN en-wikipedia-org-9224 534 4 Guermonprez Guermonprez NNP en-wikipedia-org-9224 534 5 P P NNP en-wikipedia-org-9224 534 6 , , , en-wikipedia-org-9224 534 7 Valladeau Valladeau NNP en-wikipedia-org-9224 534 8 J J NNP en-wikipedia-org-9224 534 9 , , , en-wikipedia-org-9224 534 10 Zitvogel Zitvogel NNP en-wikipedia-org-9224 534 11 L L NNP en-wikipedia-org-9224 534 12 , , , en-wikipedia-org-9224 534 13 Théry Théry NNP en-wikipedia-org-9224 534 14 C C NNP en-wikipedia-org-9224 534 15 , , , en-wikipedia-org-9224 534 16 Amigorena Amigorena NNP en-wikipedia-org-9224 534 17 S S NNP en-wikipedia-org-9224 534 18 ( ( -LRB- en-wikipedia-org-9224 534 19 2002 2002 CD en-wikipedia-org-9224 534 20 ) ) -RRB- en-wikipedia-org-9224 534 21 . . . en-wikipedia-org-9224 535 1 " " `` en-wikipedia-org-9224 535 2 Antigen Antigen NNP en-wikipedia-org-9224 535 3 presentation presentation NN en-wikipedia-org-9224 535 4 and and CC en-wikipedia-org-9224 535 5 T t JJ en-wikipedia-org-9224 535 6 cell cell NN en-wikipedia-org-9224 535 7 stimulation stimulation NN en-wikipedia-org-9224 535 8 by by IN en-wikipedia-org-9224 535 9 dendritic dendritic JJ en-wikipedia-org-9224 535 10 cells cell NNS en-wikipedia-org-9224 535 11 " " '' en-wikipedia-org-9224 535 12 . . . en-wikipedia-org-9224 536 1 Annual Annual NNP en-wikipedia-org-9224 536 2 Review Review NNP en-wikipedia-org-9224 536 3 of of IN en-wikipedia-org-9224 536 4 Immunology Immunology NNP en-wikipedia-org-9224 536 5 . . . en-wikipedia-org-9224 537 1 20 20 CD en-wikipedia-org-9224 537 2 ( ( -LRB- en-wikipedia-org-9224 537 3 1 1 CD en-wikipedia-org-9224 537 4 ) ) -RRB- en-wikipedia-org-9224 537 5 : : : en-wikipedia-org-9224 537 6 621–67 621–67 CD en-wikipedia-org-9224 537 7 . . . en-wikipedia-org-9224 538 1 doi:10.1146 doi:10.1146 NNP en-wikipedia-org-9224 538 2 / / SYM en-wikipedia-org-9224 538 3 annurev.immunol.20.100301.064828 annurev.immunol.20.100301.064828 NNP en-wikipedia-org-9224 538 4 . . . en-wikipedia-org-9224 539 1 PMID PMID NNP en-wikipedia-org-9224 539 2   _SP en-wikipedia-org-9224 539 3 11861614 11861614 CD en-wikipedia-org-9224 539 4 . . . en-wikipedia-org-9224 540 1 ^ ^ NNP en-wikipedia-org-9224 540 2 Krishnaswamy Krishnaswamy NNP en-wikipedia-org-9224 540 3 , , , en-wikipedia-org-9224 540 4 Ajitawi Ajitawi NNP en-wikipedia-org-9224 540 5 & & CC en-wikipedia-org-9224 540 6 Chi Chi NNP en-wikipedia-org-9224 540 7 2006 2006 CD en-wikipedia-org-9224 540 8 , , , en-wikipedia-org-9224 540 9 pp pp NNP en-wikipedia-org-9224 540 10 . . . en-wikipedia-org-9224 541 1 13–34 13–34 CD en-wikipedia-org-9224 541 2 . . . en-wikipedia-org-9224 542 1 ^ ^ NNP en-wikipedia-org-9224 542 2 Kariyawasam Kariyawasam NNP en-wikipedia-org-9224 542 3 HH HH NNP en-wikipedia-org-9224 542 4 , , , en-wikipedia-org-9224 542 5 Robinson Robinson NNP en-wikipedia-org-9224 542 6 DS DS NNP en-wikipedia-org-9224 542 7 ( ( -LRB- en-wikipedia-org-9224 542 8 April April NNP en-wikipedia-org-9224 542 9 2006 2006 CD en-wikipedia-org-9224 542 10 ) ) -RRB- en-wikipedia-org-9224 542 11 . . . en-wikipedia-org-9224 543 1 " " `` en-wikipedia-org-9224 543 2 The the DT en-wikipedia-org-9224 543 3 eosinophil eosinophil NNS en-wikipedia-org-9224 543 4 : : : en-wikipedia-org-9224 543 5 the the DT en-wikipedia-org-9224 543 6 cell cell NN en-wikipedia-org-9224 543 7 and and CC en-wikipedia-org-9224 543 8 its -PRON- PRP$ en-wikipedia-org-9224 543 9 weapons weapon NNS en-wikipedia-org-9224 543 10 , , , en-wikipedia-org-9224 543 11 the the DT en-wikipedia-org-9224 543 12 cytokines cytokine NNS en-wikipedia-org-9224 543 13 , , , en-wikipedia-org-9224 543 14 its -PRON- PRP$ en-wikipedia-org-9224 543 15 locations location NNS en-wikipedia-org-9224 543 16 " " '' en-wikipedia-org-9224 543 17 . . . en-wikipedia-org-9224 544 1 Seminars seminar NNS en-wikipedia-org-9224 544 2 in in IN en-wikipedia-org-9224 544 3 Respiratory Respiratory NNP en-wikipedia-org-9224 544 4 and and CC en-wikipedia-org-9224 544 5 Critical Critical NNP en-wikipedia-org-9224 544 6 Care Care NNP en-wikipedia-org-9224 544 7 Medicine medicine NN en-wikipedia-org-9224 544 8 . . . en-wikipedia-org-9224 545 1 27 27 CD en-wikipedia-org-9224 545 2 ( ( -LRB- en-wikipedia-org-9224 545 3 2 2 CD en-wikipedia-org-9224 545 4 ) ) -RRB- en-wikipedia-org-9224 545 5 : : : en-wikipedia-org-9224 545 6 117–27 117–27 CD en-wikipedia-org-9224 545 7 . . . en-wikipedia-org-9224 546 1 doi:10.1055 doi:10.1055 NNP en-wikipedia-org-9224 546 2 / / SYM en-wikipedia-org-9224 546 3 s-2006 s-2006 NNP en-wikipedia-org-9224 546 4 - - HYPH en-wikipedia-org-9224 546 5 939514 939514 CD en-wikipedia-org-9224 546 6 . . . en-wikipedia-org-9224 547 1 PMID PMID NNP en-wikipedia-org-9224 547 2   _SP en-wikipedia-org-9224 547 3 16612762 16612762 CD en-wikipedia-org-9224 547 4 . . . en-wikipedia-org-9224 548 1 ^ ^ NNP en-wikipedia-org-9224 548 2 Spits Spits NNPS en-wikipedia-org-9224 548 3 H H NNP en-wikipedia-org-9224 548 4 , , , en-wikipedia-org-9224 548 5 Cupedo Cupedo NNP en-wikipedia-org-9224 548 6 T T NNP en-wikipedia-org-9224 548 7 ( ( -LRB- en-wikipedia-org-9224 548 8 2012 2012 CD en-wikipedia-org-9224 548 9 ) ) -RRB- en-wikipedia-org-9224 548 10 . . . en-wikipedia-org-9224 549 1 " " `` en-wikipedia-org-9224 549 2 Innate innate VB en-wikipedia-org-9224 549 3 lymphoid lymphoid JJ en-wikipedia-org-9224 549 4 cells cell NNS en-wikipedia-org-9224 549 5 : : : en-wikipedia-org-9224 549 6 emerging emerge VBG en-wikipedia-org-9224 549 7 insights insight NNS en-wikipedia-org-9224 549 8 in in IN en-wikipedia-org-9224 549 9 development development NN en-wikipedia-org-9224 549 10 , , , en-wikipedia-org-9224 549 11 lineage lineage NN en-wikipedia-org-9224 549 12 relationships relationship NNS en-wikipedia-org-9224 549 13 , , , en-wikipedia-org-9224 549 14 and and CC en-wikipedia-org-9224 549 15 function function NN en-wikipedia-org-9224 549 16 " " '' en-wikipedia-org-9224 549 17 . . . en-wikipedia-org-9224 550 1 Annual Annual NNP en-wikipedia-org-9224 550 2 Review Review NNP en-wikipedia-org-9224 550 3 of of IN en-wikipedia-org-9224 550 4 Immunology Immunology NNP en-wikipedia-org-9224 550 5 . . . en-wikipedia-org-9224 551 1 30 30 CD en-wikipedia-org-9224 551 2 : : SYM en-wikipedia-org-9224 551 3 647–75 647–75 CD en-wikipedia-org-9224 551 4 . . . en-wikipedia-org-9224 552 1 doi:10.1146 doi:10.1146 NNP en-wikipedia-org-9224 552 2 / / SYM en-wikipedia-org-9224 552 3 annurev annurev JJ en-wikipedia-org-9224 552 4 - - HYPH en-wikipedia-org-9224 552 5 immunol-020711 immunol-020711 NN en-wikipedia-org-9224 552 6 - - HYPH en-wikipedia-org-9224 552 7 075053 075053 CD en-wikipedia-org-9224 552 8 . . . en-wikipedia-org-9224 553 1 PMID PMID NNP en-wikipedia-org-9224 553 2   _SP en-wikipedia-org-9224 553 3 22224763 22224763 CD en-wikipedia-org-9224 553 4 . . . en-wikipedia-org-9224 554 1 ^ ^ NNP en-wikipedia-org-9224 554 2 Gabrielli Gabrielli NNP en-wikipedia-org-9224 554 3 S S NNP en-wikipedia-org-9224 554 4 , , , en-wikipedia-org-9224 554 5 Ortolani Ortolani NNP en-wikipedia-org-9224 554 6 C C NNP en-wikipedia-org-9224 554 7 , , , en-wikipedia-org-9224 554 8 Del Del NNP en-wikipedia-org-9224 554 9 Zotto Zotto NNP en-wikipedia-org-9224 554 10 G G NNP en-wikipedia-org-9224 554 11 , , , en-wikipedia-org-9224 554 12 Luchetti Luchetti NNP en-wikipedia-org-9224 554 13 F F NNP en-wikipedia-org-9224 554 14 , , , en-wikipedia-org-9224 554 15 Canonico Canonico NNP en-wikipedia-org-9224 554 16 B B NNP en-wikipedia-org-9224 554 17 , , , en-wikipedia-org-9224 554 18 Buccella Buccella NNP en-wikipedia-org-9224 554 19 F F NNP en-wikipedia-org-9224 554 20 , , , en-wikipedia-org-9224 554 21 Artico Artico NNP en-wikipedia-org-9224 554 22 M M NNP en-wikipedia-org-9224 554 23 , , , en-wikipedia-org-9224 554 24 Papa Papa NNP en-wikipedia-org-9224 554 25 S S NNP en-wikipedia-org-9224 554 26 , , , en-wikipedia-org-9224 554 27 Zamai Zamai NNP en-wikipedia-org-9224 554 28 L L NNP en-wikipedia-org-9224 554 29 ( ( -LRB- en-wikipedia-org-9224 554 30 2016 2016 CD en-wikipedia-org-9224 554 31 ) ) -RRB- en-wikipedia-org-9224 554 32 . . . en-wikipedia-org-9224 555 1 " " `` en-wikipedia-org-9224 555 2 The the DT en-wikipedia-org-9224 555 3 Memories Memories NNPS en-wikipedia-org-9224 555 4 of of IN en-wikipedia-org-9224 555 5 NK NK NNP en-wikipedia-org-9224 555 6 Cells Cells NNPS en-wikipedia-org-9224 555 7 : : : en-wikipedia-org-9224 555 8 Innate innate VB en-wikipedia-org-9224 555 9 - - HYPH en-wikipedia-org-9224 555 10 Adaptive adaptive JJ en-wikipedia-org-9224 555 11 Immune Immune NNP en-wikipedia-org-9224 555 12 Intrinsic Intrinsic NNP en-wikipedia-org-9224 555 13 Crosstalk Crosstalk NNP en-wikipedia-org-9224 555 14 " " '' en-wikipedia-org-9224 555 15 . . . en-wikipedia-org-9224 556 1 Journal Journal NNP en-wikipedia-org-9224 556 2 of of IN en-wikipedia-org-9224 556 3 Immunology Immunology NNP en-wikipedia-org-9224 556 4 Research Research NNP en-wikipedia-org-9224 556 5 . . . en-wikipedia-org-9224 557 1 2016 2016 CD en-wikipedia-org-9224 557 2 : : : en-wikipedia-org-9224 557 3 1376595 1376595 CD en-wikipedia-org-9224 557 4 . . . en-wikipedia-org-9224 557 5 doi:10.1155/2016/1376595 doi:10.1155/2016/1376595 NNP en-wikipedia-org-9224 557 6 . . . en-wikipedia-org-9224 558 1 PMC PMC NNP en-wikipedia-org-9224 558 2   _SP en-wikipedia-org-9224 558 3 5204097 5204097 CD en-wikipedia-org-9224 558 4 . . . en-wikipedia-org-9224 559 1 PMID PMID NNP en-wikipedia-org-9224 559 2   _SP en-wikipedia-org-9224 559 3 28078307 28078307 CD en-wikipedia-org-9224 559 4 . . . en-wikipedia-org-9224 560 1 ^ ^ NNP en-wikipedia-org-9224 560 2 a a DT en-wikipedia-org-9224 560 3 b b NNP en-wikipedia-org-9224 560 4 c c NNP en-wikipedia-org-9224 560 5 d d NN en-wikipedia-org-9224 560 6 e e NNP en-wikipedia-org-9224 560 7 f f NNP en-wikipedia-org-9224 560 8 Janeway Janeway NNP en-wikipedia-org-9224 560 9 2005 2005 CD en-wikipedia-org-9224 560 10 . . . en-wikipedia-org-9224 561 1 ^ ^ NNP en-wikipedia-org-9224 561 2 Rajalingam Rajalingam NNP en-wikipedia-org-9224 561 3 2012 2012 CD en-wikipedia-org-9224 561 4 , , , en-wikipedia-org-9224 561 5 Chapter chapter NN en-wikipedia-org-9224 561 6 : : . en-wikipedia-org-9224 561 7 Overview overview NN en-wikipedia-org-9224 561 8 of of IN en-wikipedia-org-9224 561 9 the the DT en-wikipedia-org-9224 561 10 killer killer NN en-wikipedia-org-9224 561 11 cell cell NN en-wikipedia-org-9224 561 12 immunoglobulin immunoglobulin NNP en-wikipedia-org-9224 561 13 - - HYPH en-wikipedia-org-9224 561 14 like like JJ en-wikipedia-org-9224 561 15 receptor receptor NN en-wikipedia-org-9224 561 16 system system NN en-wikipedia-org-9224 561 17 . . . en-wikipedia-org-9224 562 1 ^ ^ NNP en-wikipedia-org-9224 562 2 a a DT en-wikipedia-org-9224 562 3 b b NN en-wikipedia-org-9224 562 4 Kawai Kawai NNP en-wikipedia-org-9224 562 5 T T NNP en-wikipedia-org-9224 562 6 , , , en-wikipedia-org-9224 562 7 Akira Akira NNP en-wikipedia-org-9224 562 8 S S NNP en-wikipedia-org-9224 562 9 ( ( -LRB- en-wikipedia-org-9224 562 10 February February NNP en-wikipedia-org-9224 562 11 2006 2006 CD en-wikipedia-org-9224 562 12 ) ) -RRB- en-wikipedia-org-9224 562 13 . . . en-wikipedia-org-9224 563 1 " " `` en-wikipedia-org-9224 563 2 Innate innate VB en-wikipedia-org-9224 563 3 immune immune JJ en-wikipedia-org-9224 563 4 recognition recognition NN en-wikipedia-org-9224 563 5 of of IN en-wikipedia-org-9224 563 6 viral viral JJ en-wikipedia-org-9224 563 7 infection infection NN en-wikipedia-org-9224 563 8 " " '' en-wikipedia-org-9224 563 9 . . . en-wikipedia-org-9224 564 1 Nature Nature NNP en-wikipedia-org-9224 564 2 Immunology Immunology NNP en-wikipedia-org-9224 564 3 . . . en-wikipedia-org-9224 565 1 7 7 CD en-wikipedia-org-9224 565 2 ( ( -LRB- en-wikipedia-org-9224 565 3 2 2 CD en-wikipedia-org-9224 565 4 ) ) -RRB- en-wikipedia-org-9224 565 5 : : : en-wikipedia-org-9224 565 6 131–37 131–37 CD en-wikipedia-org-9224 565 7 . . . en-wikipedia-org-9224 566 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 566 2 / / SYM en-wikipedia-org-9224 566 3 ni1303 ni1303 NNP en-wikipedia-org-9224 566 4 . . . en-wikipedia-org-9224 567 1 PMID PMID NNP en-wikipedia-org-9224 567 2   _SP en-wikipedia-org-9224 567 3 16424890 16424890 CD en-wikipedia-org-9224 567 4 . . . en-wikipedia-org-9224 568 1 S2CID S2CID NNS en-wikipedia-org-9224 568 2   _SP en-wikipedia-org-9224 568 3 9567407 9567407 CD en-wikipedia-org-9224 568 4 . . . en-wikipedia-org-9224 569 1 ^ ^ NNP en-wikipedia-org-9224 569 2 a a DT en-wikipedia-org-9224 569 3 b b NN en-wikipedia-org-9224 569 4 Miller Miller NNP en-wikipedia-org-9224 569 5 SB SB NNP en-wikipedia-org-9224 569 6 ( ( -LRB- en-wikipedia-org-9224 569 7 August August NNP en-wikipedia-org-9224 569 8 2006 2006 CD en-wikipedia-org-9224 569 9 ) ) -RRB- en-wikipedia-org-9224 569 10 . . . en-wikipedia-org-9224 570 1 " " `` en-wikipedia-org-9224 570 2 Prostaglandins Prostaglandins NNPS en-wikipedia-org-9224 570 3 in in IN en-wikipedia-org-9224 570 4 health health NN en-wikipedia-org-9224 570 5 and and CC en-wikipedia-org-9224 570 6 disease disease NN en-wikipedia-org-9224 570 7 : : : en-wikipedia-org-9224 570 8 an an DT en-wikipedia-org-9224 570 9 overview overview NN en-wikipedia-org-9224 570 10 " " '' en-wikipedia-org-9224 570 11 . . . en-wikipedia-org-9224 571 1 Seminars Seminars NNPS en-wikipedia-org-9224 571 2 in in IN en-wikipedia-org-9224 571 3 Arthritis Arthritis NNP en-wikipedia-org-9224 571 4 and and CC en-wikipedia-org-9224 571 5 Rheumatism Rheumatism NNP en-wikipedia-org-9224 571 6 . . . en-wikipedia-org-9224 572 1 36 36 CD en-wikipedia-org-9224 572 2 ( ( -LRB- en-wikipedia-org-9224 572 3 1 1 CD en-wikipedia-org-9224 572 4 ) ) -RRB- en-wikipedia-org-9224 572 5 : : : en-wikipedia-org-9224 572 6 37–49 37–49 NNP en-wikipedia-org-9224 572 7 . . . en-wikipedia-org-9224 573 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 573 2 / / SYM en-wikipedia-org-9224 573 3 j.semarthrit.2006.03.005 j.semarthrit.2006.03.005 NN en-wikipedia-org-9224 573 4 . . . en-wikipedia-org-9224 574 1 PMID PMID NNP en-wikipedia-org-9224 574 2   _SP en-wikipedia-org-9224 574 3 16887467 16887467 CD en-wikipedia-org-9224 574 4 . . . en-wikipedia-org-9224 575 1 ^ ^ NNP en-wikipedia-org-9224 575 2 a a DT en-wikipedia-org-9224 575 3 b b NN en-wikipedia-org-9224 575 4 Ogawa Ogawa NNP en-wikipedia-org-9224 575 5 Y Y NNP en-wikipedia-org-9224 575 6 , , , en-wikipedia-org-9224 575 7 Calhoun Calhoun NNP en-wikipedia-org-9224 575 8 WJ WJ NNP en-wikipedia-org-9224 575 9 ( ( -LRB- en-wikipedia-org-9224 575 10 October October NNP en-wikipedia-org-9224 575 11 2006 2006 CD en-wikipedia-org-9224 575 12 ) ) -RRB- en-wikipedia-org-9224 575 13 . . . en-wikipedia-org-9224 576 1 " " `` en-wikipedia-org-9224 576 2 The the DT en-wikipedia-org-9224 576 3 role role NN en-wikipedia-org-9224 576 4 of of IN en-wikipedia-org-9224 576 5 leukotrienes leukotriene NNS en-wikipedia-org-9224 576 6 in in IN en-wikipedia-org-9224 576 7 airway airway NN en-wikipedia-org-9224 576 8 inflammation inflammation NN en-wikipedia-org-9224 576 9 " " '' en-wikipedia-org-9224 576 10 . . . en-wikipedia-org-9224 577 1 The the DT en-wikipedia-org-9224 577 2 Journal Journal NNP en-wikipedia-org-9224 577 3 of of IN en-wikipedia-org-9224 577 4 Allergy Allergy NNP en-wikipedia-org-9224 577 5 and and CC en-wikipedia-org-9224 577 6 Clinical Clinical NNP en-wikipedia-org-9224 577 7 Immunology Immunology NNP en-wikipedia-org-9224 577 8 . . . en-wikipedia-org-9224 578 1 118 118 CD en-wikipedia-org-9224 578 2 ( ( -LRB- en-wikipedia-org-9224 578 3 4 4 CD en-wikipedia-org-9224 578 4 ) ) -RRB- en-wikipedia-org-9224 578 5 : : : en-wikipedia-org-9224 578 6 789–98 789–98 CD en-wikipedia-org-9224 578 7 , , , en-wikipedia-org-9224 578 8 quiz quiz NN en-wikipedia-org-9224 578 9 799–800 799–800 CD en-wikipedia-org-9224 578 10 . . . en-wikipedia-org-9224 579 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 579 2 / / SYM en-wikipedia-org-9224 579 3 j.jaci.2006.08.009 j.jaci.2006.08.009 CD en-wikipedia-org-9224 579 4 . . . en-wikipedia-org-9224 580 1 PMID PMID NNP en-wikipedia-org-9224 580 2   _SP en-wikipedia-org-9224 580 3 17030228 17030228 CD en-wikipedia-org-9224 580 4 . . . en-wikipedia-org-9224 581 1 ^ ^ NNP en-wikipedia-org-9224 581 2 a a DT en-wikipedia-org-9224 581 3 b b NN en-wikipedia-org-9224 581 4 Le Le NNP en-wikipedia-org-9224 581 5 Y Y NNP en-wikipedia-org-9224 581 6 , , , en-wikipedia-org-9224 581 7 Zhou Zhou NNP en-wikipedia-org-9224 581 8 Y Y NNP en-wikipedia-org-9224 581 9 , , , en-wikipedia-org-9224 581 10 Iribarren Iribarren NNP en-wikipedia-org-9224 581 11 P P NNP en-wikipedia-org-9224 581 12 , , , en-wikipedia-org-9224 581 13 Wang Wang NNP en-wikipedia-org-9224 581 14 J J NNP en-wikipedia-org-9224 581 15 ( ( -LRB- en-wikipedia-org-9224 581 16 April April NNP en-wikipedia-org-9224 581 17 2004 2004 CD en-wikipedia-org-9224 581 18 ) ) -RRB- en-wikipedia-org-9224 581 19 . . . en-wikipedia-org-9224 582 1 " " `` en-wikipedia-org-9224 582 2 Chemokines Chemokines NNPS en-wikipedia-org-9224 582 3 and and CC en-wikipedia-org-9224 582 4 chemokine chemokine NN en-wikipedia-org-9224 582 5 receptors receptor NNS en-wikipedia-org-9224 582 6 : : : en-wikipedia-org-9224 582 7 their -PRON- PRP$ en-wikipedia-org-9224 582 8 manifold manifold JJ en-wikipedia-org-9224 582 9 roles role NNS en-wikipedia-org-9224 582 10 in in IN en-wikipedia-org-9224 582 11 homeostasis homeostasis NN en-wikipedia-org-9224 582 12 and and CC en-wikipedia-org-9224 582 13 disease disease NN en-wikipedia-org-9224 582 14 " " '' en-wikipedia-org-9224 582 15 ( ( -LRB- en-wikipedia-org-9224 582 16 PDF PDF NNP en-wikipedia-org-9224 582 17 ) ) -RRB- en-wikipedia-org-9224 582 18 . . . en-wikipedia-org-9224 583 1 Cellular Cellular NNP en-wikipedia-org-9224 583 2 & & CC en-wikipedia-org-9224 583 3 Molecular Molecular NNP en-wikipedia-org-9224 583 4 Immunology Immunology NNP en-wikipedia-org-9224 583 5 . . . en-wikipedia-org-9224 584 1 1 1 CD en-wikipedia-org-9224 584 2 ( ( -LRB- en-wikipedia-org-9224 584 3 2 2 CD en-wikipedia-org-9224 584 4 ) ) -RRB- en-wikipedia-org-9224 584 5 : : : en-wikipedia-org-9224 584 6 95–104 95–104 CD en-wikipedia-org-9224 584 7 . . . en-wikipedia-org-9224 585 1 PMID PMID NNP en-wikipedia-org-9224 585 2   _SP en-wikipedia-org-9224 585 3 16212895 16212895 CD en-wikipedia-org-9224 585 4 . . . en-wikipedia-org-9224 586 1 ^ ^ NNP en-wikipedia-org-9224 586 2 a a DT en-wikipedia-org-9224 586 3 b b NN en-wikipedia-org-9224 586 4 Martin Martin NNP en-wikipedia-org-9224 586 5 P P NNP en-wikipedia-org-9224 586 6 , , , en-wikipedia-org-9224 586 7 Leibovich Leibovich NNP en-wikipedia-org-9224 586 8 SJ SJ NNP en-wikipedia-org-9224 586 9 ( ( -LRB- en-wikipedia-org-9224 586 10 November November NNP en-wikipedia-org-9224 586 11 2005 2005 CD en-wikipedia-org-9224 586 12 ) ) -RRB- en-wikipedia-org-9224 586 13 . . . en-wikipedia-org-9224 587 1 " " `` en-wikipedia-org-9224 587 2 Inflammatory inflammatory JJ en-wikipedia-org-9224 587 3 cells cell NNS en-wikipedia-org-9224 587 4 during during IN en-wikipedia-org-9224 587 5 wound wound NNP en-wikipedia-org-9224 587 6 repair repair NN en-wikipedia-org-9224 587 7 : : : en-wikipedia-org-9224 587 8 the the DT en-wikipedia-org-9224 587 9 good good JJ en-wikipedia-org-9224 587 10 , , , en-wikipedia-org-9224 587 11 the the DT en-wikipedia-org-9224 587 12 bad bad JJ en-wikipedia-org-9224 587 13 and and CC en-wikipedia-org-9224 587 14 the the DT en-wikipedia-org-9224 587 15 ugly ugly JJ en-wikipedia-org-9224 587 16 " " '' en-wikipedia-org-9224 587 17 . . . en-wikipedia-org-9224 588 1 Trends trend NNS en-wikipedia-org-9224 588 2 in in IN en-wikipedia-org-9224 588 3 Cell Cell NNP en-wikipedia-org-9224 588 4 Biology Biology NNP en-wikipedia-org-9224 588 5 . . . en-wikipedia-org-9224 589 1 15 15 CD en-wikipedia-org-9224 589 2 ( ( -LRB- en-wikipedia-org-9224 589 3 11 11 CD en-wikipedia-org-9224 589 4 ) ) -RRB- en-wikipedia-org-9224 589 5 : : : en-wikipedia-org-9224 589 6 599–607 599–607 CD en-wikipedia-org-9224 589 7 . . . en-wikipedia-org-9224 590 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 590 2 / / SYM en-wikipedia-org-9224 590 3 j.tcb.2005.09.002 j.tcb.2005.09.002 NNP en-wikipedia-org-9224 590 4 . . . en-wikipedia-org-9224 591 1 PMID PMID NNP en-wikipedia-org-9224 591 2   _SP en-wikipedia-org-9224 591 3 16202600 16202600 CD en-wikipedia-org-9224 591 4 . . . en-wikipedia-org-9224 592 1 ^ ^ NNP en-wikipedia-org-9224 592 2 Platnich Platnich NNP en-wikipedia-org-9224 592 3 JM JM NNP en-wikipedia-org-9224 592 4 , , , en-wikipedia-org-9224 592 5 Muruve Muruve NNP en-wikipedia-org-9224 592 6 DA DA NNP en-wikipedia-org-9224 592 7 ( ( -LRB- en-wikipedia-org-9224 592 8 February February NNP en-wikipedia-org-9224 592 9 2019 2019 CD en-wikipedia-org-9224 592 10 ) ) -RRB- en-wikipedia-org-9224 592 11 . . . en-wikipedia-org-9224 593 1 " " `` en-wikipedia-org-9224 593 2 NOD NOD NNP en-wikipedia-org-9224 593 3 - - HYPH en-wikipedia-org-9224 593 4 like like JJ en-wikipedia-org-9224 593 5 receptors receptor NNS en-wikipedia-org-9224 593 6 and and CC en-wikipedia-org-9224 593 7 inflammasomes inflammasome NNS en-wikipedia-org-9224 593 8 : : : en-wikipedia-org-9224 593 9 A a DT en-wikipedia-org-9224 593 10 review review NN en-wikipedia-org-9224 593 11 of of IN en-wikipedia-org-9224 593 12 their -PRON- PRP$ en-wikipedia-org-9224 593 13 canonical canonical JJ en-wikipedia-org-9224 593 14 and and CC en-wikipedia-org-9224 593 15 non non JJ en-wikipedia-org-9224 593 16 - - JJ en-wikipedia-org-9224 593 17 canonical canonical JJ en-wikipedia-org-9224 593 18 signaling signaling NN en-wikipedia-org-9224 593 19 pathways pathway NNS en-wikipedia-org-9224 593 20 " " '' en-wikipedia-org-9224 593 21 . . . en-wikipedia-org-9224 594 1 Archives archive NNS en-wikipedia-org-9224 594 2 of of IN en-wikipedia-org-9224 594 3 Biochemistry Biochemistry NNP en-wikipedia-org-9224 594 4 and and CC en-wikipedia-org-9224 594 5 Biophysics Biophysics NNPS en-wikipedia-org-9224 594 6 . . . en-wikipedia-org-9224 595 1 670 670 CD en-wikipedia-org-9224 595 2 : : : en-wikipedia-org-9224 595 3 4–14 4–14 JJ en-wikipedia-org-9224 595 4 . . . en-wikipedia-org-9224 596 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 596 2 / / SYM en-wikipedia-org-9224 596 3 j.abb.2019.02.008 j.abb.2019.02.008 NNP en-wikipedia-org-9224 596 4 . . . en-wikipedia-org-9224 597 1 PMID PMID NNP en-wikipedia-org-9224 597 2   _SP en-wikipedia-org-9224 597 3 30772258 30772258 CD en-wikipedia-org-9224 597 4 . . . en-wikipedia-org-9224 598 1 ^ ^ NNP en-wikipedia-org-9224 598 2 a a DT en-wikipedia-org-9224 598 3 b b NNP en-wikipedia-org-9224 598 4 Rus Rus NNP en-wikipedia-org-9224 598 5 H H NNP en-wikipedia-org-9224 598 6 , , , en-wikipedia-org-9224 598 7 Cudrici Cudrici NNP en-wikipedia-org-9224 598 8 C C NNP en-wikipedia-org-9224 598 9 , , , en-wikipedia-org-9224 598 10 Niculescu Niculescu NNP en-wikipedia-org-9224 598 11 F F NNP en-wikipedia-org-9224 598 12 ( ( -LRB- en-wikipedia-org-9224 598 13 2005 2005 CD en-wikipedia-org-9224 598 14 ) ) -RRB- en-wikipedia-org-9224 598 15 . . . en-wikipedia-org-9224 599 1 " " `` en-wikipedia-org-9224 599 2 The the DT en-wikipedia-org-9224 599 3 role role NN en-wikipedia-org-9224 599 4 of of IN en-wikipedia-org-9224 599 5 the the DT en-wikipedia-org-9224 599 6 complement complement JJ en-wikipedia-org-9224 599 7 system system NN en-wikipedia-org-9224 599 8 in in IN en-wikipedia-org-9224 599 9 innate innate NN en-wikipedia-org-9224 599 10 immunity immunity NN en-wikipedia-org-9224 599 11 " " '' en-wikipedia-org-9224 599 12 . . . en-wikipedia-org-9224 600 1 Immunologic Immunologic NNP en-wikipedia-org-9224 600 2 Research Research NNP en-wikipedia-org-9224 600 3 . . . en-wikipedia-org-9224 601 1 33 33 CD en-wikipedia-org-9224 601 2 ( ( -LRB- en-wikipedia-org-9224 601 3 2 2 CD en-wikipedia-org-9224 601 4 ) ) -RRB- en-wikipedia-org-9224 601 5 : : : en-wikipedia-org-9224 601 6 103–12 103–12 CD en-wikipedia-org-9224 601 7 . . . en-wikipedia-org-9224 602 1 doi:10.1385 doi:10.1385 NNP en-wikipedia-org-9224 602 2 / / SYM en-wikipedia-org-9224 602 3 IR:33:2:103 IR:33:2:103 NNP en-wikipedia-org-9224 602 4 . . . en-wikipedia-org-9224 603 1 PMID PMID NNP en-wikipedia-org-9224 603 2   _SP en-wikipedia-org-9224 603 3 16234578 16234578 CD en-wikipedia-org-9224 603 4 . . . en-wikipedia-org-9224 604 1 S2CID S2CID NNS en-wikipedia-org-9224 604 2   _SP en-wikipedia-org-9224 604 3 46096567 46096567 CD en-wikipedia-org-9224 604 4 . . . en-wikipedia-org-9224 605 1 ^ ^ NNP en-wikipedia-org-9224 605 2 Degn Degn NNP en-wikipedia-org-9224 605 3 SE SE NNP en-wikipedia-org-9224 605 4 , , , en-wikipedia-org-9224 605 5 Thiel Thiel NNP en-wikipedia-org-9224 605 6 S S NNP en-wikipedia-org-9224 605 7 ( ( -LRB- en-wikipedia-org-9224 605 8 August August NNP en-wikipedia-org-9224 605 9 2013 2013 CD en-wikipedia-org-9224 605 10 ) ) -RRB- en-wikipedia-org-9224 605 11 . . . en-wikipedia-org-9224 606 1 " " `` en-wikipedia-org-9224 606 2 Humoral humoral JJ en-wikipedia-org-9224 606 3 pattern pattern NN en-wikipedia-org-9224 606 4 recognition recognition NN en-wikipedia-org-9224 606 5 and and CC en-wikipedia-org-9224 606 6 the the DT en-wikipedia-org-9224 606 7 complement complement NN en-wikipedia-org-9224 606 8 system system NN en-wikipedia-org-9224 606 9 " " '' en-wikipedia-org-9224 606 10 . . . en-wikipedia-org-9224 607 1 Scandinavian Scandinavian NNP en-wikipedia-org-9224 607 2 Journal Journal NNP en-wikipedia-org-9224 607 3 of of IN en-wikipedia-org-9224 607 4 Immunology Immunology NNP en-wikipedia-org-9224 607 5 . . . en-wikipedia-org-9224 608 1 78 78 CD en-wikipedia-org-9224 608 2 ( ( -LRB- en-wikipedia-org-9224 608 3 2 2 CD en-wikipedia-org-9224 608 4 ) ) -RRB- en-wikipedia-org-9224 608 5 : : : en-wikipedia-org-9224 608 6 181–93 181–93 CD en-wikipedia-org-9224 608 7 . . . en-wikipedia-org-9224 609 1 doi:10.1111 doi:10.1111 NNP en-wikipedia-org-9224 609 2 / / SYM en-wikipedia-org-9224 609 3 sji.12070 sji.12070 NN en-wikipedia-org-9224 609 4 . . . en-wikipedia-org-9224 610 1 PMID PMID NNP en-wikipedia-org-9224 610 2   _SP en-wikipedia-org-9224 610 3 23672641 23672641 CD en-wikipedia-org-9224 610 4 . . . en-wikipedia-org-9224 611 1 ^ ^ NFP en-wikipedia-org-9224 611 2 Liszewski Liszewski NNP en-wikipedia-org-9224 611 3 MK MK NNP en-wikipedia-org-9224 611 4 , , , en-wikipedia-org-9224 611 5 Farries farrie VBZ en-wikipedia-org-9224 611 6 TC TC NNP en-wikipedia-org-9224 611 7 , , , en-wikipedia-org-9224 611 8 Lublin Lublin NNP en-wikipedia-org-9224 611 9 DM DM NNP en-wikipedia-org-9224 611 10 , , , en-wikipedia-org-9224 611 11 Rooney Rooney NNP en-wikipedia-org-9224 611 12 IA IA NNP en-wikipedia-org-9224 611 13 , , , en-wikipedia-org-9224 611 14 Atkinson Atkinson NNP en-wikipedia-org-9224 611 15 JP JP NNP en-wikipedia-org-9224 611 16 ( ( -LRB- en-wikipedia-org-9224 611 17 1996 1996 CD en-wikipedia-org-9224 611 18 ) ) -RRB- en-wikipedia-org-9224 611 19 . . . en-wikipedia-org-9224 612 1 " " `` en-wikipedia-org-9224 612 2 Control Control NNP en-wikipedia-org-9224 612 3 of of IN en-wikipedia-org-9224 612 4 the the DT en-wikipedia-org-9224 612 5 complement complement NN en-wikipedia-org-9224 612 6 system system NN en-wikipedia-org-9224 612 7 " " '' en-wikipedia-org-9224 612 8 . . . en-wikipedia-org-9224 613 1 Advances advance NNS en-wikipedia-org-9224 613 2 in in IN en-wikipedia-org-9224 613 3 Immunology immunology NN en-wikipedia-org-9224 613 4 . . . en-wikipedia-org-9224 614 1 61 61 CD en-wikipedia-org-9224 614 2 : : : en-wikipedia-org-9224 614 3 201–283 201–283 CD en-wikipedia-org-9224 614 4 . . . en-wikipedia-org-9224 615 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 615 2 / / SYM en-wikipedia-org-9224 615 3 S0065 S0065 NNP en-wikipedia-org-9224 615 4 - - HYPH en-wikipedia-org-9224 615 5 2776(08)60868 2776(08)60868 NNP en-wikipedia-org-9224 615 6 - - HYPH en-wikipedia-org-9224 615 7 8 8 NNP en-wikipedia-org-9224 615 8 . . . en-wikipedia-org-9224 616 1 ISBN ISBN NNP en-wikipedia-org-9224 616 2   _SP en-wikipedia-org-9224 616 3 978 978 CD en-wikipedia-org-9224 616 4 - - HYPH en-wikipedia-org-9224 616 5 0 0 CD en-wikipedia-org-9224 616 6 - - HYPH en-wikipedia-org-9224 616 7 12 12 CD en-wikipedia-org-9224 616 8 - - HYPH en-wikipedia-org-9224 616 9 022461 022461 CD en-wikipedia-org-9224 616 10 - - HYPH en-wikipedia-org-9224 616 11 6 6 CD en-wikipedia-org-9224 616 12 . . . en-wikipedia-org-9224 617 1 PMID PMID NNP en-wikipedia-org-9224 617 2   _SP en-wikipedia-org-9224 617 3 8834497 8834497 CD en-wikipedia-org-9224 617 4 . . . en-wikipedia-org-9224 618 1 ^ ^ NNP en-wikipedia-org-9224 618 2 Sim Sim NNP en-wikipedia-org-9224 618 3 RB RB NNP en-wikipedia-org-9224 618 4 , , , en-wikipedia-org-9224 618 5 Tsiftsoglou Tsiftsoglou NNP en-wikipedia-org-9224 618 6 SA SA NNP en-wikipedia-org-9224 618 7 ( ( -LRB- en-wikipedia-org-9224 618 8 February February NNP en-wikipedia-org-9224 618 9 2004 2004 CD en-wikipedia-org-9224 618 10 ) ) -RRB- en-wikipedia-org-9224 618 11 . . . en-wikipedia-org-9224 619 1 " " `` en-wikipedia-org-9224 619 2 Proteases protease NNS en-wikipedia-org-9224 619 3 of of IN en-wikipedia-org-9224 619 4 the the DT en-wikipedia-org-9224 619 5 complement complement NN en-wikipedia-org-9224 619 6 system system NN en-wikipedia-org-9224 619 7 " " '' en-wikipedia-org-9224 619 8 . . . en-wikipedia-org-9224 620 1 Biochemical Biochemical NNP en-wikipedia-org-9224 620 2 Society Society NNP en-wikipedia-org-9224 620 3 Transactions Transactions NNPS en-wikipedia-org-9224 620 4 . . . en-wikipedia-org-9224 621 1 32 32 CD en-wikipedia-org-9224 621 2 ( ( -LRB- en-wikipedia-org-9224 621 3 Pt Pt NNP en-wikipedia-org-9224 621 4 1 1 CD en-wikipedia-org-9224 621 5 ) ) -RRB- en-wikipedia-org-9224 621 6 : : : en-wikipedia-org-9224 621 7 21–27 21–27 CD en-wikipedia-org-9224 621 8 . . . en-wikipedia-org-9224 622 1 doi:10.1042 doi:10.1042 NNP en-wikipedia-org-9224 622 2 / / SYM en-wikipedia-org-9224 622 3 BST0320021 BST0320021 NNP en-wikipedia-org-9224 622 4 . . . en-wikipedia-org-9224 623 1 PMID PMID NNP en-wikipedia-org-9224 623 2   _SP en-wikipedia-org-9224 623 3 14748705 14748705 CD en-wikipedia-org-9224 623 4 . . . en-wikipedia-org-9224 624 1 S2CID S2CID NNS en-wikipedia-org-9224 624 2   _SP en-wikipedia-org-9224 624 3 24505041 24505041 CD en-wikipedia-org-9224 624 4 . . . en-wikipedia-org-9224 625 1 ^ ^ NNP en-wikipedia-org-9224 625 2 Pancer Pancer NNP en-wikipedia-org-9224 625 3 Z Z NNP en-wikipedia-org-9224 625 4 , , , en-wikipedia-org-9224 625 5 Cooper Cooper NNP en-wikipedia-org-9224 625 6 MD MD NNP en-wikipedia-org-9224 625 7 ( ( -LRB- en-wikipedia-org-9224 625 8 2006 2006 CD en-wikipedia-org-9224 625 9 ) ) -RRB- en-wikipedia-org-9224 625 10 . . . en-wikipedia-org-9224 626 1 " " `` en-wikipedia-org-9224 626 2 The the DT en-wikipedia-org-9224 626 3 evolution evolution NN en-wikipedia-org-9224 626 4 of of IN en-wikipedia-org-9224 626 5 adaptive adaptive JJ en-wikipedia-org-9224 626 6 immunity immunity NN en-wikipedia-org-9224 626 7 " " '' en-wikipedia-org-9224 626 8 . . . en-wikipedia-org-9224 627 1 Annual Annual NNP en-wikipedia-org-9224 627 2 Review Review NNP en-wikipedia-org-9224 627 3 of of IN en-wikipedia-org-9224 627 4 Immunology Immunology NNP en-wikipedia-org-9224 627 5 . . . en-wikipedia-org-9224 628 1 24 24 CD en-wikipedia-org-9224 628 2 ( ( -LRB- en-wikipedia-org-9224 628 3 1 1 CD en-wikipedia-org-9224 628 4 ) ) -RRB- en-wikipedia-org-9224 628 5 : : : en-wikipedia-org-9224 628 6 497–518 497–518 CD en-wikipedia-org-9224 628 7 . . . en-wikipedia-org-9224 629 1 doi:10.1146 doi:10.1146 NNP en-wikipedia-org-9224 629 2 / / SYM en-wikipedia-org-9224 629 3 annurev.immunol.24.021605.090542 annurev.immunol.24.021605.090542 NNP en-wikipedia-org-9224 629 4 . . . en-wikipedia-org-9224 630 1 PMID PMID NNP en-wikipedia-org-9224 630 2   _SP en-wikipedia-org-9224 630 3 16551257 16551257 CD en-wikipedia-org-9224 630 4 . . . en-wikipedia-org-9224 631 1 ^ ^ NNP en-wikipedia-org-9224 631 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 631 3 2019 2019 CD en-wikipedia-org-9224 631 4 , , , en-wikipedia-org-9224 631 5 p. p. NN en-wikipedia-org-9224 631 6   _SP en-wikipedia-org-9224 631 7 38 38 CD en-wikipedia-org-9224 631 8 . . . en-wikipedia-org-9224 632 1 ^ ^ NNP en-wikipedia-org-9224 632 2 a a DT en-wikipedia-org-9224 632 3 b b NN en-wikipedia-org-9224 632 4 Holtmeier Holtmeier NNP en-wikipedia-org-9224 632 5 W W NNP en-wikipedia-org-9224 632 6 , , , en-wikipedia-org-9224 632 7 Kabelitz Kabelitz NNP en-wikipedia-org-9224 632 8 D D NNP en-wikipedia-org-9224 632 9 ( ( -LRB- en-wikipedia-org-9224 632 10 2005 2005 CD en-wikipedia-org-9224 632 11 ) ) -RRB- en-wikipedia-org-9224 632 12 . . . en-wikipedia-org-9224 633 1 " " `` en-wikipedia-org-9224 633 2 gammadelta gammadelta NNP en-wikipedia-org-9224 633 3 T T NNP en-wikipedia-org-9224 633 4 cells cell NNS en-wikipedia-org-9224 633 5 link link VBP en-wikipedia-org-9224 633 6 innate innate VBP en-wikipedia-org-9224 633 7 and and CC en-wikipedia-org-9224 633 8 adaptive adaptive JJ en-wikipedia-org-9224 633 9 immune immune JJ en-wikipedia-org-9224 633 10 responses response NNS en-wikipedia-org-9224 633 11 " " '' en-wikipedia-org-9224 633 12 . . . en-wikipedia-org-9224 634 1 Chemical Chemical NNP en-wikipedia-org-9224 634 2 Immunology Immunology NNP en-wikipedia-org-9224 634 3 and and CC en-wikipedia-org-9224 634 4 Allergy Allergy NNP en-wikipedia-org-9224 634 5 . . . en-wikipedia-org-9224 635 1 86 86 CD en-wikipedia-org-9224 635 2 : : SYM en-wikipedia-org-9224 635 3 151–83 151–83 CD en-wikipedia-org-9224 635 4 . . . en-wikipedia-org-9224 636 1 doi:10.1159/000086659 doi:10.1159/000086659 NNP en-wikipedia-org-9224 636 2 . . . en-wikipedia-org-9224 637 1 ISBN ISBN NNP en-wikipedia-org-9224 637 2   _SP en-wikipedia-org-9224 637 3 3 3 CD en-wikipedia-org-9224 637 4 - - HYPH en-wikipedia-org-9224 637 5 8055 8055 CD en-wikipedia-org-9224 637 6 - - HYPH en-wikipedia-org-9224 637 7 7862 7862 CD en-wikipedia-org-9224 637 8 - - HYPH en-wikipedia-org-9224 637 9 8 8 CD en-wikipedia-org-9224 637 10 . . . en-wikipedia-org-9224 638 1 PMID PMID NNP en-wikipedia-org-9224 638 2   _SP en-wikipedia-org-9224 638 3 15976493 15976493 CD en-wikipedia-org-9224 638 4 . . . en-wikipedia-org-9224 639 1 ^ ^ NNP en-wikipedia-org-9224 639 2 Venturi Venturi NNP en-wikipedia-org-9224 639 3 S S NNP en-wikipedia-org-9224 639 4 , , , en-wikipedia-org-9224 639 5 Venturi venturi NN en-wikipedia-org-9224 639 6 M M NNP en-wikipedia-org-9224 639 7 ( ( -LRB- en-wikipedia-org-9224 639 8 September September NNP en-wikipedia-org-9224 639 9 2009 2009 CD en-wikipedia-org-9224 639 10 ) ) -RRB- en-wikipedia-org-9224 639 11 . . . en-wikipedia-org-9224 640 1 " " `` en-wikipedia-org-9224 640 2 Iodine Iodine NNP en-wikipedia-org-9224 640 3 , , , en-wikipedia-org-9224 640 4 thymus thymus NN en-wikipedia-org-9224 640 5 , , , en-wikipedia-org-9224 640 6 and and CC en-wikipedia-org-9224 640 7 immunity immunity NN en-wikipedia-org-9224 640 8 " " '' en-wikipedia-org-9224 640 9 . . . en-wikipedia-org-9224 641 1 Nutrition nutrition NN en-wikipedia-org-9224 641 2 . . . en-wikipedia-org-9224 642 1 25 25 CD en-wikipedia-org-9224 642 2 ( ( -LRB- en-wikipedia-org-9224 642 3 9 9 CD en-wikipedia-org-9224 642 4 ) ) -RRB- en-wikipedia-org-9224 642 5 : : : en-wikipedia-org-9224 642 6 977–79 977–79 CD en-wikipedia-org-9224 642 7 . . . en-wikipedia-org-9224 643 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 643 2 / / SYM en-wikipedia-org-9224 643 3 j.nut.2009.06.002 j.nut.2009.06.002 NNP en-wikipedia-org-9224 643 4 . . . en-wikipedia-org-9224 644 1 PMID PMID NNP en-wikipedia-org-9224 644 2   _SP en-wikipedia-org-9224 644 3 19647627 19647627 CD en-wikipedia-org-9224 644 4 . . . en-wikipedia-org-9224 645 1 ^ ^ NNP en-wikipedia-org-9224 645 2 Janeway Janeway NNP en-wikipedia-org-9224 645 3 , , , en-wikipedia-org-9224 645 4 Travers Travers NNP en-wikipedia-org-9224 645 5 & & CC en-wikipedia-org-9224 645 6 Walport Walport NNP en-wikipedia-org-9224 645 7 2001 2001 CD en-wikipedia-org-9224 645 8 , , , en-wikipedia-org-9224 645 9 sec sec NNP en-wikipedia-org-9224 645 10 . . . en-wikipedia-org-9224 646 1 12 12 CD en-wikipedia-org-9224 646 2 - - SYM en-wikipedia-org-9224 646 3 10 10 CD en-wikipedia-org-9224 646 4 . . . en-wikipedia-org-9224 647 1 ^ ^ NNP en-wikipedia-org-9224 647 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 647 3 2019 2019 CD en-wikipedia-org-9224 647 4 , , , en-wikipedia-org-9224 647 5 pp pp NNP en-wikipedia-org-9224 647 6 . . . en-wikipedia-org-9224 648 1 5–6 5–6 CD en-wikipedia-org-9224 648 2 . . . en-wikipedia-org-9224 649 1 ^ ^ NNP en-wikipedia-org-9224 649 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 649 3 2019 2019 CD en-wikipedia-org-9224 649 4 , , , en-wikipedia-org-9224 649 5 pp pp NNP en-wikipedia-org-9224 649 6 . . . en-wikipedia-org-9224 650 1 51–53 51–53 CD en-wikipedia-org-9224 650 2 . . . en-wikipedia-org-9224 651 1 ^ ^ NNP en-wikipedia-org-9224 651 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 651 3 2019 2019 CD en-wikipedia-org-9224 651 4 , , , en-wikipedia-org-9224 651 5 pp pp NNP en-wikipedia-org-9224 651 6 . . . en-wikipedia-org-9224 652 1 7–8 7–8 LS en-wikipedia-org-9224 652 2 . . . en-wikipedia-org-9224 653 1 ^ ^ NNP en-wikipedia-org-9224 653 2 Harty Harty NNP en-wikipedia-org-9224 653 3 JT JT NNP en-wikipedia-org-9224 653 4 , , , en-wikipedia-org-9224 653 5 Tvinnereim Tvinnereim NNP en-wikipedia-org-9224 653 6 AR AR NNP en-wikipedia-org-9224 653 7 , , , en-wikipedia-org-9224 653 8 White White NNP en-wikipedia-org-9224 653 9 DW DW NNP en-wikipedia-org-9224 653 10 ( ( -LRB- en-wikipedia-org-9224 653 11 2000 2000 CD en-wikipedia-org-9224 653 12 ) ) -RRB- en-wikipedia-org-9224 653 13 . . . en-wikipedia-org-9224 654 1 " " `` en-wikipedia-org-9224 654 2 CD8 CD8 NNP en-wikipedia-org-9224 654 3 + + NNP en-wikipedia-org-9224 654 4 T T NNP en-wikipedia-org-9224 654 5 cell cell NN en-wikipedia-org-9224 654 6 effector effector NN en-wikipedia-org-9224 654 7 mechanisms mechanism NNS en-wikipedia-org-9224 654 8 in in IN en-wikipedia-org-9224 654 9 resistance resistance NN en-wikipedia-org-9224 654 10 to to IN en-wikipedia-org-9224 654 11 infection infection NN en-wikipedia-org-9224 654 12 " " '' en-wikipedia-org-9224 654 13 . . . en-wikipedia-org-9224 655 1 Annual Annual NNP en-wikipedia-org-9224 655 2 Review Review NNP en-wikipedia-org-9224 655 3 of of IN en-wikipedia-org-9224 655 4 Immunology Immunology NNP en-wikipedia-org-9224 655 5 . . . en-wikipedia-org-9224 656 1 18 18 CD en-wikipedia-org-9224 656 2 ( ( -LRB- en-wikipedia-org-9224 656 3 1 1 CD en-wikipedia-org-9224 656 4 ) ) -RRB- en-wikipedia-org-9224 656 5 : : : en-wikipedia-org-9224 656 6 275–308 275–308 CD en-wikipedia-org-9224 656 7 . . . en-wikipedia-org-9224 657 1 doi:10.1146 doi:10.1146 NNP en-wikipedia-org-9224 657 2 / / SYM en-wikipedia-org-9224 657 3 annurev.immunol.18.1.275 annurev.immunol.18.1.275 NNP en-wikipedia-org-9224 657 4 . . . en-wikipedia-org-9224 658 1 PMID PMID NNP en-wikipedia-org-9224 658 2   _SP en-wikipedia-org-9224 658 3 10837060 10837060 CD en-wikipedia-org-9224 658 4 . . . en-wikipedia-org-9224 659 1 ^ ^ NNP en-wikipedia-org-9224 659 2 a a DT en-wikipedia-org-9224 659 3 b b NNP en-wikipedia-org-9224 659 4 Radoja Radoja NNP en-wikipedia-org-9224 659 5 S S NNP en-wikipedia-org-9224 659 6 , , , en-wikipedia-org-9224 659 7 Frey Frey NNP en-wikipedia-org-9224 659 8 AB AB NNP en-wikipedia-org-9224 659 9 , , , en-wikipedia-org-9224 659 10 Vukmanovic Vukmanovic NNP en-wikipedia-org-9224 659 11 S S NNP en-wikipedia-org-9224 659 12 ( ( -LRB- en-wikipedia-org-9224 659 13 2006 2006 CD en-wikipedia-org-9224 659 14 ) ) -RRB- en-wikipedia-org-9224 659 15 . . . en-wikipedia-org-9224 660 1 " " `` en-wikipedia-org-9224 660 2 T t NN en-wikipedia-org-9224 660 3 - - HYPH en-wikipedia-org-9224 660 4 cell cell NN en-wikipedia-org-9224 660 5 receptor receptor NN en-wikipedia-org-9224 660 6 signaling signal VBG en-wikipedia-org-9224 660 7 events event NNS en-wikipedia-org-9224 660 8 triggering trigger VBG en-wikipedia-org-9224 660 9 granule granule JJ en-wikipedia-org-9224 660 10 exocytosis exocytosis NN en-wikipedia-org-9224 660 11 " " '' en-wikipedia-org-9224 660 12 . . . en-wikipedia-org-9224 661 1 Critical Critical NNP en-wikipedia-org-9224 661 2 Reviews Reviews NNPS en-wikipedia-org-9224 661 3 in in IN en-wikipedia-org-9224 661 4 Immunology Immunology NNP en-wikipedia-org-9224 661 5 . . . en-wikipedia-org-9224 662 1 26 26 CD en-wikipedia-org-9224 662 2 ( ( -LRB- en-wikipedia-org-9224 662 3 3 3 CD en-wikipedia-org-9224 662 4 ) ) -RRB- en-wikipedia-org-9224 662 5 : : : en-wikipedia-org-9224 662 6 265–90 265–90 CD en-wikipedia-org-9224 662 7 . . . en-wikipedia-org-9224 663 1 doi:10.1615 doi:10.1615 NNP en-wikipedia-org-9224 663 2 / / SYM en-wikipedia-org-9224 663 3 CritRevImmunol.v26.i3.40 CritRevImmunol.v26.i3.40 NNP en-wikipedia-org-9224 663 4 . . . en-wikipedia-org-9224 664 1 PMID PMID NNP en-wikipedia-org-9224 664 2   _SP en-wikipedia-org-9224 664 3 16928189 16928189 CD en-wikipedia-org-9224 664 4 . . . en-wikipedia-org-9224 665 1 ^ ^ NNP en-wikipedia-org-9224 665 2 Abbas Abbas NNP en-wikipedia-org-9224 665 3 AK AK NNP en-wikipedia-org-9224 665 4 , , , en-wikipedia-org-9224 665 5 Murphy Murphy NNP en-wikipedia-org-9224 665 6 KM KM NNP en-wikipedia-org-9224 665 7 , , , en-wikipedia-org-9224 665 8 Sher Sher NNP en-wikipedia-org-9224 665 9 A A NNP en-wikipedia-org-9224 665 10 ( ( -LRB- en-wikipedia-org-9224 665 11 October October NNP en-wikipedia-org-9224 665 12 1996 1996 CD en-wikipedia-org-9224 665 13 ) ) -RRB- en-wikipedia-org-9224 665 14 . . . en-wikipedia-org-9224 666 1 " " `` en-wikipedia-org-9224 666 2 Functional functional JJ en-wikipedia-org-9224 666 3 diversity diversity NN en-wikipedia-org-9224 666 4 of of IN en-wikipedia-org-9224 666 5 helper helper NN en-wikipedia-org-9224 666 6 T t NN en-wikipedia-org-9224 666 7 lymphocytes lymphocyte VBZ en-wikipedia-org-9224 666 8 " " '' en-wikipedia-org-9224 666 9 . . . en-wikipedia-org-9224 667 1 Nature nature NN en-wikipedia-org-9224 667 2 . . . en-wikipedia-org-9224 668 1 383 383 CD en-wikipedia-org-9224 668 2 ( ( -LRB- en-wikipedia-org-9224 668 3 6603 6603 CD en-wikipedia-org-9224 668 4 ) ) -RRB- en-wikipedia-org-9224 668 5 : : : en-wikipedia-org-9224 668 6 787–93 787–93 CD en-wikipedia-org-9224 668 7 . . . en-wikipedia-org-9224 669 1 Bibcode:1996Natur.383 bibcode:1996natur.383 CD en-wikipedia-org-9224 669 2 .. .. NFP en-wikipedia-org-9224 669 3 787A. 787a. CD en-wikipedia-org-9224 670 1 doi:10.1038/383787a0 doi:10.1038/383787a0 NN en-wikipedia-org-9224 670 2 . . . en-wikipedia-org-9224 671 1 PMID PMID NNP en-wikipedia-org-9224 671 2   _SP en-wikipedia-org-9224 671 3 8893001 8893001 CD en-wikipedia-org-9224 671 4 . . . en-wikipedia-org-9224 672 1 S2CID S2CID NNS en-wikipedia-org-9224 672 2   _SP en-wikipedia-org-9224 672 3 4319699 4319699 CD en-wikipedia-org-9224 672 4 . . . en-wikipedia-org-9224 673 1 ^ ^ NNP en-wikipedia-org-9224 673 2 McHeyzer McHeyzer NNP en-wikipedia-org-9224 673 3 - - HYPH en-wikipedia-org-9224 673 4 Williams Williams NNP en-wikipedia-org-9224 673 5 LJ LJ NNP en-wikipedia-org-9224 673 6 , , , en-wikipedia-org-9224 673 7 Malherbe Malherbe NNP en-wikipedia-org-9224 673 8 LP LP NNP en-wikipedia-org-9224 673 9 , , , en-wikipedia-org-9224 673 10 McHeyzer McHeyzer NNP en-wikipedia-org-9224 673 11 - - HYPH en-wikipedia-org-9224 673 12 Williams Williams NNP en-wikipedia-org-9224 673 13 MG MG NNP en-wikipedia-org-9224 673 14 ( ( -LRB- en-wikipedia-org-9224 673 15 2006 2006 CD en-wikipedia-org-9224 673 16 ) ) -RRB- en-wikipedia-org-9224 673 17 . . . en-wikipedia-org-9224 674 1 " " `` en-wikipedia-org-9224 674 2 Helper helper NN en-wikipedia-org-9224 674 3 T T NNP en-wikipedia-org-9224 674 4 cell cell NN en-wikipedia-org-9224 674 5 - - HYPH en-wikipedia-org-9224 674 6 regulated regulate VBN en-wikipedia-org-9224 674 7 B b NN en-wikipedia-org-9224 674 8 cell cell NN en-wikipedia-org-9224 674 9 immunity immunity NN en-wikipedia-org-9224 674 10 " " '' en-wikipedia-org-9224 674 11 . . . en-wikipedia-org-9224 675 1 Current current JJ en-wikipedia-org-9224 675 2 Topics Topics NNPS en-wikipedia-org-9224 675 3 in in IN en-wikipedia-org-9224 675 4 Microbiology Microbiology NNP en-wikipedia-org-9224 675 5 and and CC en-wikipedia-org-9224 675 6 Immunology immunology NN en-wikipedia-org-9224 675 7 . . . en-wikipedia-org-9224 676 1 311 311 CD en-wikipedia-org-9224 676 2 : : : en-wikipedia-org-9224 676 3 59–83 59–83 CD en-wikipedia-org-9224 676 4 . . . en-wikipedia-org-9224 677 1 doi:10.1007/3 doi:10.1007/3 : en-wikipedia-org-9224 677 2 - - HYPH en-wikipedia-org-9224 677 3 540 540 CD en-wikipedia-org-9224 677 4 - - HYPH en-wikipedia-org-9224 677 5 32636 32636 CD en-wikipedia-org-9224 677 6 - - HYPH en-wikipedia-org-9224 677 7 7_3 7_3 CD en-wikipedia-org-9224 677 8 . . . en-wikipedia-org-9224 678 1 ISBN ISBN NNP en-wikipedia-org-9224 678 2   _SP en-wikipedia-org-9224 678 3 978 978 CD en-wikipedia-org-9224 678 4 - - HYPH en-wikipedia-org-9224 678 5 3 3 CD en-wikipedia-org-9224 678 6 - - HYPH en-wikipedia-org-9224 678 7 540 540 CD en-wikipedia-org-9224 678 8 - - HYPH en-wikipedia-org-9224 678 9 32635 32635 CD en-wikipedia-org-9224 678 10 - - SYM en-wikipedia-org-9224 678 11 9 9 CD en-wikipedia-org-9224 678 12 . . . en-wikipedia-org-9224 679 1 PMID PMID NNP en-wikipedia-org-9224 679 2   _SP en-wikipedia-org-9224 679 3 17048705 17048705 CD en-wikipedia-org-9224 679 4 . . . en-wikipedia-org-9224 680 1 ^ ^ NNP en-wikipedia-org-9224 680 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 680 3 2019 2019 CD en-wikipedia-org-9224 680 4 , , , en-wikipedia-org-9224 680 5 p. p. NN en-wikipedia-org-9224 680 6   _SP en-wikipedia-org-9224 680 7 8 8 CD en-wikipedia-org-9224 680 8 . . . en-wikipedia-org-9224 681 1 ^ ^ NFP en-wikipedia-org-9224 681 2 Kovacs Kovacs NNP en-wikipedia-org-9224 681 3 B B NNP en-wikipedia-org-9224 681 4 , , , en-wikipedia-org-9224 681 5 Maus Maus NNP en-wikipedia-org-9224 681 6 MV MV NNP en-wikipedia-org-9224 681 7 , , , en-wikipedia-org-9224 681 8 Riley Riley NNP en-wikipedia-org-9224 681 9 JL JL NNP en-wikipedia-org-9224 681 10 , , , en-wikipedia-org-9224 681 11 Derimanov Derimanov NNP en-wikipedia-org-9224 681 12 GS GS NNP en-wikipedia-org-9224 681 13 , , , en-wikipedia-org-9224 681 14 Koretzky Koretzky NNP en-wikipedia-org-9224 681 15 GA GA NNP en-wikipedia-org-9224 681 16 , , , en-wikipedia-org-9224 681 17 June June NNP en-wikipedia-org-9224 681 18 CH CH NNP en-wikipedia-org-9224 681 19 , , , en-wikipedia-org-9224 681 20 Finkel Finkel NNP en-wikipedia-org-9224 681 21 TH TH NNP en-wikipedia-org-9224 681 22 ( ( -LRB- en-wikipedia-org-9224 681 23 November November NNP en-wikipedia-org-9224 681 24 2002 2002 CD en-wikipedia-org-9224 681 25 ) ) -RRB- en-wikipedia-org-9224 681 26 . . . en-wikipedia-org-9224 682 1 " " `` en-wikipedia-org-9224 682 2 Human human JJ en-wikipedia-org-9224 682 3 CD8 cd8 NN en-wikipedia-org-9224 682 4 + + CC en-wikipedia-org-9224 682 5 T t NN en-wikipedia-org-9224 682 6 cells cell NNS en-wikipedia-org-9224 682 7 do do VBP en-wikipedia-org-9224 682 8 not not RB en-wikipedia-org-9224 682 9 require require VB en-wikipedia-org-9224 682 10 the the DT en-wikipedia-org-9224 682 11 polarization polarization NN en-wikipedia-org-9224 682 12 of of IN en-wikipedia-org-9224 682 13 lipid lipid NN en-wikipedia-org-9224 682 14 rafts raft NNS en-wikipedia-org-9224 682 15 for for IN en-wikipedia-org-9224 682 16 activation activation NN en-wikipedia-org-9224 682 17 and and CC en-wikipedia-org-9224 682 18 proliferation proliferation NN en-wikipedia-org-9224 682 19 " " '' en-wikipedia-org-9224 682 20 . . . en-wikipedia-org-9224 683 1 Proceedings proceeding NNS en-wikipedia-org-9224 683 2 of of IN en-wikipedia-org-9224 683 3 the the DT en-wikipedia-org-9224 683 4 National National NNP en-wikipedia-org-9224 683 5 Academy Academy NNP en-wikipedia-org-9224 683 6 of of IN en-wikipedia-org-9224 683 7 Sciences Sciences NNPS en-wikipedia-org-9224 683 8 of of IN en-wikipedia-org-9224 683 9 the the DT en-wikipedia-org-9224 683 10 United United NNP en-wikipedia-org-9224 683 11 States States NNP en-wikipedia-org-9224 683 12 of of IN en-wikipedia-org-9224 683 13 America America NNP en-wikipedia-org-9224 683 14 . . . en-wikipedia-org-9224 684 1 99 99 CD en-wikipedia-org-9224 684 2 ( ( -LRB- en-wikipedia-org-9224 684 3 23 23 CD en-wikipedia-org-9224 684 4 ) ) -RRB- en-wikipedia-org-9224 684 5 : : : en-wikipedia-org-9224 684 6 15006–11 15006–11 LS en-wikipedia-org-9224 684 7 . . . en-wikipedia-org-9224 685 1 Bibcode:2002PNAS bibcode:2002pnas UH en-wikipedia-org-9224 685 2 ... ... : en-wikipedia-org-9224 685 3 9915006K. 9915006K. NNS en-wikipedia-org-9224 686 1 doi:10.1073 doi:10.1073 NNP en-wikipedia-org-9224 686 2 / / SYM en-wikipedia-org-9224 686 3 pnas.232058599 pnas.232058599 NN en-wikipedia-org-9224 686 4 . . . en-wikipedia-org-9224 687 1 PMC PMC NNP en-wikipedia-org-9224 687 2   _SP en-wikipedia-org-9224 687 3 137535 137535 CD en-wikipedia-org-9224 687 4 . . . en-wikipedia-org-9224 688 1 PMID PMID NNP en-wikipedia-org-9224 688 2   _SP en-wikipedia-org-9224 688 3 12419850 12419850 CD en-wikipedia-org-9224 688 4 . . . en-wikipedia-org-9224 689 1 ^ ^ NNP en-wikipedia-org-9224 689 2 Alberts Alberts NNP en-wikipedia-org-9224 689 3 et et FW en-wikipedia-org-9224 689 4 al al NNP en-wikipedia-org-9224 689 5 . . . en-wikipedia-org-9224 690 1 2002 2002 CD en-wikipedia-org-9224 690 2 , , , en-wikipedia-org-9224 690 3 Chapter chapter NN en-wikipedia-org-9224 690 4 . . . en-wikipedia-org-9224 691 1 " " `` en-wikipedia-org-9224 691 2 Helper helper NN en-wikipedia-org-9224 691 3 T T NNP en-wikipedia-org-9224 691 4 Cells Cells NNPS en-wikipedia-org-9224 691 5 and and CC en-wikipedia-org-9224 691 6 Lymphocyte Lymphocyte NNP en-wikipedia-org-9224 691 7 Activation Activation NNP en-wikipedia-org-9224 691 8 " " '' en-wikipedia-org-9224 691 9 . . . en-wikipedia-org-9224 692 1 ^ ^ NNP en-wikipedia-org-9224 692 2 Grewal Grewal NNP en-wikipedia-org-9224 692 3 IS IS NNP en-wikipedia-org-9224 692 4 , , , en-wikipedia-org-9224 692 5 Flavell Flavell NNP en-wikipedia-org-9224 692 6 RA RA NNP en-wikipedia-org-9224 692 7 ( ( -LRB- en-wikipedia-org-9224 692 8 1998 1998 CD en-wikipedia-org-9224 692 9 ) ) -RRB- en-wikipedia-org-9224 692 10 . . . en-wikipedia-org-9224 693 1 " " `` en-wikipedia-org-9224 693 2 CD40 CD40 NNP en-wikipedia-org-9224 693 3 and and CC en-wikipedia-org-9224 693 4 CD154 cd154 NN en-wikipedia-org-9224 693 5 in in IN en-wikipedia-org-9224 693 6 cell cell NN en-wikipedia-org-9224 693 7 - - HYPH en-wikipedia-org-9224 693 8 mediated mediate VBN en-wikipedia-org-9224 693 9 immunity immunity NN en-wikipedia-org-9224 693 10 " " '' en-wikipedia-org-9224 693 11 . . . en-wikipedia-org-9224 694 1 Annual Annual NNP en-wikipedia-org-9224 694 2 Review Review NNP en-wikipedia-org-9224 694 3 of of IN en-wikipedia-org-9224 694 4 Immunology Immunology NNP en-wikipedia-org-9224 694 5 . . . en-wikipedia-org-9224 695 1 16 16 CD en-wikipedia-org-9224 695 2 ( ( -LRB- en-wikipedia-org-9224 695 3 1 1 CD en-wikipedia-org-9224 695 4 ) ) -RRB- en-wikipedia-org-9224 695 5 : : : en-wikipedia-org-9224 695 6 111–35 111–35 CD en-wikipedia-org-9224 695 7 . . . en-wikipedia-org-9224 696 1 doi:10.1146 doi:10.1146 NNP en-wikipedia-org-9224 696 2 / / SYM en-wikipedia-org-9224 696 3 annurev.immunol.16.1.111 annurev.immunol.16.1.111 JJ en-wikipedia-org-9224 696 4 . . . en-wikipedia-org-9224 697 1 PMID PMID NNP en-wikipedia-org-9224 697 2   _SP en-wikipedia-org-9224 697 3 9597126 9597126 CD en-wikipedia-org-9224 697 4 . . . en-wikipedia-org-9224 698 1 ^ ^ NNP en-wikipedia-org-9224 698 2 Girardi Girardi NNP en-wikipedia-org-9224 698 3 M M NNP en-wikipedia-org-9224 698 4 ( ( -LRB- en-wikipedia-org-9224 698 5 January January NNP en-wikipedia-org-9224 698 6 2006 2006 CD en-wikipedia-org-9224 698 7 ) ) -RRB- en-wikipedia-org-9224 698 8 . . . en-wikipedia-org-9224 699 1 " " `` en-wikipedia-org-9224 699 2 Immunosurveillance immunosurveillance NN en-wikipedia-org-9224 699 3 and and CC en-wikipedia-org-9224 699 4 immunoregulation immunoregulation NN en-wikipedia-org-9224 699 5 by by IN en-wikipedia-org-9224 699 6 gammadelta gammadelta NNP en-wikipedia-org-9224 699 7 T T NNP en-wikipedia-org-9224 699 8 cells cell NNS en-wikipedia-org-9224 699 9 " " '' en-wikipedia-org-9224 699 10 . . . en-wikipedia-org-9224 700 1 The the DT en-wikipedia-org-9224 700 2 Journal Journal NNP en-wikipedia-org-9224 700 3 of of IN en-wikipedia-org-9224 700 4 Investigative Investigative NNP en-wikipedia-org-9224 700 5 Dermatology Dermatology NNP en-wikipedia-org-9224 700 6 . . . en-wikipedia-org-9224 701 1 126 126 CD en-wikipedia-org-9224 701 2 ( ( -LRB- en-wikipedia-org-9224 701 3 1 1 CD en-wikipedia-org-9224 701 4 ) ) -RRB- en-wikipedia-org-9224 701 5 : : : en-wikipedia-org-9224 701 6 25–31 25–31 CD en-wikipedia-org-9224 701 7 . . . en-wikipedia-org-9224 702 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 702 2 / / SYM en-wikipedia-org-9224 702 3 sj.jid.5700003 sj.jid.5700003 JJ en-wikipedia-org-9224 702 4 . . . en-wikipedia-org-9224 703 1 PMID PMID NNP en-wikipedia-org-9224 703 2   _SP en-wikipedia-org-9224 703 3 16417214 16417214 CD en-wikipedia-org-9224 703 4 . . . en-wikipedia-org-9224 704 1 ^ ^ FW en-wikipedia-org-9224 704 2 " " `` en-wikipedia-org-9224 704 3 Understanding understand VBG en-wikipedia-org-9224 704 4 the the DT en-wikipedia-org-9224 704 5 Immune Immune NNP en-wikipedia-org-9224 704 6 System system NN en-wikipedia-org-9224 704 7 : : : en-wikipedia-org-9224 704 8 How how WRB en-wikipedia-org-9224 704 9 it -PRON- PRP en-wikipedia-org-9224 704 10 Works work VBZ en-wikipedia-org-9224 704 11 " " '' en-wikipedia-org-9224 704 12 ( ( -LRB- en-wikipedia-org-9224 704 13 PDF PDF NNP en-wikipedia-org-9224 704 14 ) ) -RRB- en-wikipedia-org-9224 704 15 . . . en-wikipedia-org-9224 705 1 National National NNP en-wikipedia-org-9224 705 2 Institute Institute NNP en-wikipedia-org-9224 705 3 of of IN en-wikipedia-org-9224 705 4 Allergy Allergy NNP en-wikipedia-org-9224 705 5 and and CC en-wikipedia-org-9224 705 6 Infectious Infectious NNP en-wikipedia-org-9224 705 7 Diseases Diseases NNPS en-wikipedia-org-9224 705 8 ( ( -LRB- en-wikipedia-org-9224 705 9 NIAID NIAID NNP en-wikipedia-org-9224 705 10 ) ) -RRB- en-wikipedia-org-9224 705 11 . . . en-wikipedia-org-9224 706 1 Archived archived JJ en-wikipedia-org-9224 706 2 from from IN en-wikipedia-org-9224 706 3 the the DT en-wikipedia-org-9224 706 4 original original JJ en-wikipedia-org-9224 706 5 ( ( -LRB- en-wikipedia-org-9224 706 6 PDF PDF NNP en-wikipedia-org-9224 706 7 ) ) -RRB- en-wikipedia-org-9224 706 8 on on IN en-wikipedia-org-9224 706 9 3 3 CD en-wikipedia-org-9224 706 10 January January NNP en-wikipedia-org-9224 706 11 2007 2007 CD en-wikipedia-org-9224 706 12 . . . en-wikipedia-org-9224 707 1 Retrieved Retrieved NNP en-wikipedia-org-9224 707 2 1 1 CD en-wikipedia-org-9224 707 3 January January NNP en-wikipedia-org-9224 707 4 2007 2007 CD en-wikipedia-org-9224 707 5 . . . en-wikipedia-org-9224 708 1 ^ ^ NNP en-wikipedia-org-9224 708 2 a a DT en-wikipedia-org-9224 708 3 b b NNP en-wikipedia-org-9224 708 4 Sproul Sproul NNP en-wikipedia-org-9224 708 5 TW TW NNP en-wikipedia-org-9224 708 6 , , , en-wikipedia-org-9224 708 7 Cheng Cheng NNP en-wikipedia-org-9224 708 8 PC PC NNP en-wikipedia-org-9224 708 9 , , , en-wikipedia-org-9224 708 10 Dykstra Dykstra NNP en-wikipedia-org-9224 708 11 ML ML NNP en-wikipedia-org-9224 708 12 , , , en-wikipedia-org-9224 708 13 Pierce Pierce NNP en-wikipedia-org-9224 708 14 SK SK NNP en-wikipedia-org-9224 708 15 ( ( -LRB- en-wikipedia-org-9224 708 16 2000 2000 CD en-wikipedia-org-9224 708 17 ) ) -RRB- en-wikipedia-org-9224 708 18 . . . en-wikipedia-org-9224 709 1 " " `` en-wikipedia-org-9224 709 2 A a DT en-wikipedia-org-9224 709 3 role role NN en-wikipedia-org-9224 709 4 for for IN en-wikipedia-org-9224 709 5 MHC MHC NNP en-wikipedia-org-9224 709 6 class class NN en-wikipedia-org-9224 709 7 II II NNP en-wikipedia-org-9224 709 8 antigen antigen NN en-wikipedia-org-9224 709 9 processing processing NN en-wikipedia-org-9224 709 10 in in IN en-wikipedia-org-9224 709 11 B b NN en-wikipedia-org-9224 709 12 cell cell NN en-wikipedia-org-9224 709 13 development development NN en-wikipedia-org-9224 709 14 " " '' en-wikipedia-org-9224 709 15 . . . en-wikipedia-org-9224 710 1 International International NNP en-wikipedia-org-9224 710 2 Reviews Reviews NNPS en-wikipedia-org-9224 710 3 of of IN en-wikipedia-org-9224 710 4 Immunology Immunology NNP en-wikipedia-org-9224 710 5 . . . en-wikipedia-org-9224 711 1 19 19 CD en-wikipedia-org-9224 711 2 ( ( -LRB- en-wikipedia-org-9224 711 3 2–3 2–3 CD en-wikipedia-org-9224 711 4 ) ) -RRB- en-wikipedia-org-9224 711 5 : : : en-wikipedia-org-9224 711 6 139–55 139–55 CD en-wikipedia-org-9224 711 7 . . . en-wikipedia-org-9224 712 1 doi:10.3109/08830180009088502 doi:10.3109/08830180009088502 NNP en-wikipedia-org-9224 712 2 . . . en-wikipedia-org-9224 713 1 PMID PMID NNP en-wikipedia-org-9224 713 2   _SP en-wikipedia-org-9224 713 3 10763706 10763706 CD en-wikipedia-org-9224 713 4 . . . en-wikipedia-org-9224 714 1 S2CID S2CID NNS en-wikipedia-org-9224 714 2   _SP en-wikipedia-org-9224 714 3 6550357 6550357 CD en-wikipedia-org-9224 714 4 . . . en-wikipedia-org-9224 715 1 ^ ^ NN en-wikipedia-org-9224 715 2 Parker Parker NNP en-wikipedia-org-9224 715 3 DC DC NNP en-wikipedia-org-9224 715 4 ( ( -LRB- en-wikipedia-org-9224 715 5 1993 1993 CD en-wikipedia-org-9224 715 6 ) ) -RRB- en-wikipedia-org-9224 715 7 . . . en-wikipedia-org-9224 716 1 " " `` en-wikipedia-org-9224 716 2 T T NNP en-wikipedia-org-9224 716 3 cell cell NN en-wikipedia-org-9224 716 4 - - HYPH en-wikipedia-org-9224 716 5 dependent dependent JJ en-wikipedia-org-9224 716 6 B B NNP en-wikipedia-org-9224 716 7 cell cell NN en-wikipedia-org-9224 716 8 activation activation NN en-wikipedia-org-9224 716 9 " " '' en-wikipedia-org-9224 716 10 . . . en-wikipedia-org-9224 717 1 Annual Annual NNP en-wikipedia-org-9224 717 2 Review Review NNP en-wikipedia-org-9224 717 3 of of IN en-wikipedia-org-9224 717 4 Immunology Immunology NNP en-wikipedia-org-9224 717 5 . . . en-wikipedia-org-9224 718 1 11 11 CD en-wikipedia-org-9224 718 2 : : : en-wikipedia-org-9224 718 3 331–60 331–60 CD en-wikipedia-org-9224 718 4 . . . en-wikipedia-org-9224 719 1 doi:10.1146 doi:10.1146 NNP en-wikipedia-org-9224 719 2 / / SYM en-wikipedia-org-9224 719 3 annurev.iy.11.040193.001555 annurev.iy.11.040193.001555 ADD en-wikipedia-org-9224 719 4 . . . en-wikipedia-org-9224 720 1 PMID PMID NNP en-wikipedia-org-9224 720 2   _SP en-wikipedia-org-9224 720 3 8476565 8476565 CD en-wikipedia-org-9224 720 4 . . . en-wikipedia-org-9224 721 1 ^ ^ NFP en-wikipedia-org-9224 721 2 Murphy Murphy NNP en-wikipedia-org-9224 721 3 & & CC en-wikipedia-org-9224 721 4 Weaver Weaver NNP en-wikipedia-org-9224 721 5 2016 2016 CD en-wikipedia-org-9224 721 6 , , , en-wikipedia-org-9224 721 7 Chapter chapter NN en-wikipedia-org-9224 721 8 10 10 CD en-wikipedia-org-9224 721 9 : : : en-wikipedia-org-9224 721 10 The the DT en-wikipedia-org-9224 721 11 Humoral Humoral NNP en-wikipedia-org-9224 721 12 Immune Immune NNP en-wikipedia-org-9224 721 13 Response Response NNP en-wikipedia-org-9224 721 14 . . . en-wikipedia-org-9224 722 1 ^ ^ NN en-wikipedia-org-9224 722 2 Saji Saji NNP en-wikipedia-org-9224 722 3 F F NNP en-wikipedia-org-9224 722 4 , , , en-wikipedia-org-9224 722 5 Samejima Samejima NNP en-wikipedia-org-9224 722 6 Y Y NNP en-wikipedia-org-9224 722 7 , , , en-wikipedia-org-9224 722 8 Kamiura Kamiura NNP en-wikipedia-org-9224 722 9 S S NNP en-wikipedia-org-9224 722 10 , , , en-wikipedia-org-9224 722 11 Koyama Koyama NNP en-wikipedia-org-9224 722 12 M M NNP en-wikipedia-org-9224 722 13 ( ( -LRB- en-wikipedia-org-9224 722 14 May May NNP en-wikipedia-org-9224 722 15 1999 1999 CD en-wikipedia-org-9224 722 16 ) ) -RRB- en-wikipedia-org-9224 722 17 . . . en-wikipedia-org-9224 723 1 " " `` en-wikipedia-org-9224 723 2 Dynamics dynamic NNS en-wikipedia-org-9224 723 3 of of IN en-wikipedia-org-9224 723 4 immunoglobulins immunoglobulin NNS en-wikipedia-org-9224 723 5 at at IN en-wikipedia-org-9224 723 6 the the DT en-wikipedia-org-9224 723 7 feto feto NNP en-wikipedia-org-9224 723 8 - - HYPH en-wikipedia-org-9224 723 9 maternal maternal JJ en-wikipedia-org-9224 723 10 interface interface NN en-wikipedia-org-9224 723 11 " " '' en-wikipedia-org-9224 723 12 . . . en-wikipedia-org-9224 724 1 Reviews Reviews NNP en-wikipedia-org-9224 724 2 of of IN en-wikipedia-org-9224 724 3 Reproduction Reproduction NNP en-wikipedia-org-9224 724 4 . . . en-wikipedia-org-9224 725 1 4 4 CD en-wikipedia-org-9224 725 2 ( ( -LRB- en-wikipedia-org-9224 725 3 2 2 CD en-wikipedia-org-9224 725 4 ) ) -RRB- en-wikipedia-org-9224 725 5 : : : en-wikipedia-org-9224 725 6 81–89 81–89 CD en-wikipedia-org-9224 725 7 . . . en-wikipedia-org-9224 726 1 doi:10.1530 doi:10.1530 NNP en-wikipedia-org-9224 726 2 / / SYM en-wikipedia-org-9224 726 3 ror.0.0040081 ror.0.0040081 NNS en-wikipedia-org-9224 726 4 . . . en-wikipedia-org-9224 727 1 PMID PMID NNP en-wikipedia-org-9224 727 2   _SP en-wikipedia-org-9224 727 3 10357095 10357095 CD en-wikipedia-org-9224 727 4 . . . en-wikipedia-org-9224 728 1 ^ ^ NNP en-wikipedia-org-9224 728 2 Van Van NNP en-wikipedia-org-9224 728 3 de de FW en-wikipedia-org-9224 728 4 Perre Perre NNP en-wikipedia-org-9224 728 5 P P NNP en-wikipedia-org-9224 728 6 ( ( -LRB- en-wikipedia-org-9224 728 7 July July NNP en-wikipedia-org-9224 728 8 2003 2003 CD en-wikipedia-org-9224 728 9 ) ) -RRB- en-wikipedia-org-9224 728 10 . . . en-wikipedia-org-9224 729 1 " " `` en-wikipedia-org-9224 729 2 Transfer transfer NN en-wikipedia-org-9224 729 3 of of IN en-wikipedia-org-9224 729 4 antibody antibody NN en-wikipedia-org-9224 729 5 via via IN en-wikipedia-org-9224 729 6 mother mother NN en-wikipedia-org-9224 729 7 's 's POS en-wikipedia-org-9224 729 8 milk milk NN en-wikipedia-org-9224 729 9 " " '' en-wikipedia-org-9224 729 10 . . . en-wikipedia-org-9224 730 1 Vaccine Vaccine NNP en-wikipedia-org-9224 730 2 . . . en-wikipedia-org-9224 731 1 21 21 CD en-wikipedia-org-9224 731 2 ( ( -LRB- en-wikipedia-org-9224 731 3 24 24 CD en-wikipedia-org-9224 731 4 ) ) -RRB- en-wikipedia-org-9224 731 5 : : : en-wikipedia-org-9224 731 6 3374–76 3374–76 CD en-wikipedia-org-9224 731 7 . . . en-wikipedia-org-9224 732 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 732 2 / / SYM en-wikipedia-org-9224 732 3 S0264 S0264 NNP en-wikipedia-org-9224 732 4 - - HYPH en-wikipedia-org-9224 732 5 410X(03)00336 410X(03)00336 NNP en-wikipedia-org-9224 732 6 - - HYPH en-wikipedia-org-9224 732 7 0 0 CD en-wikipedia-org-9224 732 8 . . . en-wikipedia-org-9224 733 1 PMID PMID NNP en-wikipedia-org-9224 733 2   _SP en-wikipedia-org-9224 733 3 12850343 12850343 CD en-wikipedia-org-9224 733 4 . . . en-wikipedia-org-9224 734 1 ^ ^ NFP en-wikipedia-org-9224 734 2 Keller Keller NNP en-wikipedia-org-9224 734 3 MA MA NNP en-wikipedia-org-9224 734 4 , , , en-wikipedia-org-9224 734 5 Stiehm Stiehm NNP en-wikipedia-org-9224 734 6 ER ER NNP en-wikipedia-org-9224 734 7 ( ( -LRB- en-wikipedia-org-9224 734 8 October October NNP en-wikipedia-org-9224 734 9 2000 2000 CD en-wikipedia-org-9224 734 10 ) ) -RRB- en-wikipedia-org-9224 734 11 . . . en-wikipedia-org-9224 735 1 " " `` en-wikipedia-org-9224 735 2 Passive passive JJ en-wikipedia-org-9224 735 3 immunity immunity NN en-wikipedia-org-9224 735 4 in in IN en-wikipedia-org-9224 735 5 prevention prevention NN en-wikipedia-org-9224 735 6 and and CC en-wikipedia-org-9224 735 7 treatment treatment NN en-wikipedia-org-9224 735 8 of of IN en-wikipedia-org-9224 735 9 infectious infectious JJ en-wikipedia-org-9224 735 10 diseases disease NNS en-wikipedia-org-9224 735 11 " " '' en-wikipedia-org-9224 735 12 . . . en-wikipedia-org-9224 736 1 Clinical Clinical NNP en-wikipedia-org-9224 736 2 Microbiology Microbiology NNP en-wikipedia-org-9224 736 3 Reviews Reviews NNP en-wikipedia-org-9224 736 4 . . . en-wikipedia-org-9224 737 1 13 13 CD en-wikipedia-org-9224 737 2 ( ( -LRB- en-wikipedia-org-9224 737 3 4 4 CD en-wikipedia-org-9224 737 4 ) ) -RRB- en-wikipedia-org-9224 737 5 : : : en-wikipedia-org-9224 737 6 602–14 602–14 CD en-wikipedia-org-9224 737 7 . . . en-wikipedia-org-9224 738 1 doi:10.1128 doi:10.1128 NN en-wikipedia-org-9224 738 2 / / SYM en-wikipedia-org-9224 738 3 CMR.13.4.602 CMR.13.4.602 NNP en-wikipedia-org-9224 738 4 - - HYPH en-wikipedia-org-9224 738 5 614.2000 614.2000 CD en-wikipedia-org-9224 738 6 . . . en-wikipedia-org-9224 739 1 PMC PMC NNP en-wikipedia-org-9224 739 2   _SP en-wikipedia-org-9224 739 3 88952 88952 CD en-wikipedia-org-9224 739 4 . . . en-wikipedia-org-9224 740 1 PMID PMID NNP en-wikipedia-org-9224 740 2   _SP en-wikipedia-org-9224 740 3 11023960 11023960 CD en-wikipedia-org-9224 740 4 . . . en-wikipedia-org-9224 741 1 ^ ^ NNP en-wikipedia-org-9224 741 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 741 3 2019 2019 CD en-wikipedia-org-9224 741 4 , , , en-wikipedia-org-9224 741 5 p. p. NN en-wikipedia-org-9224 741 6   _SP en-wikipedia-org-9224 741 7 98 98 CD en-wikipedia-org-9224 741 8 . . . en-wikipedia-org-9224 742 1 ^ ^ NN en-wikipedia-org-9224 742 2 Wick Wick NNP en-wikipedia-org-9224 742 3 G G NNP en-wikipedia-org-9224 742 4 , , , en-wikipedia-org-9224 742 5 Hu Hu NNP en-wikipedia-org-9224 742 6 Y Y NNP en-wikipedia-org-9224 742 7 , , , en-wikipedia-org-9224 742 8 Schwarz Schwarz NNP en-wikipedia-org-9224 742 9 S S NNP en-wikipedia-org-9224 742 10 , , , en-wikipedia-org-9224 742 11 Kroemer Kroemer NNP en-wikipedia-org-9224 742 12 G G NNP en-wikipedia-org-9224 742 13 ( ( -LRB- en-wikipedia-org-9224 742 14 October October NNP en-wikipedia-org-9224 742 15 1993 1993 CD en-wikipedia-org-9224 742 16 ) ) -RRB- en-wikipedia-org-9224 742 17 . . . en-wikipedia-org-9224 743 1 " " `` en-wikipedia-org-9224 743 2 Immunoendocrine immunoendocrine JJ en-wikipedia-org-9224 743 3 communication communication NN en-wikipedia-org-9224 743 4 via via IN en-wikipedia-org-9224 743 5 the the DT en-wikipedia-org-9224 743 6 hypothalamo hypothalamo JJ en-wikipedia-org-9224 743 7 - - HYPH en-wikipedia-org-9224 743 8 pituitary pituitary JJ en-wikipedia-org-9224 743 9 - - HYPH en-wikipedia-org-9224 743 10 adrenal adrenal NN en-wikipedia-org-9224 743 11 axis axis NN en-wikipedia-org-9224 743 12 in in IN en-wikipedia-org-9224 743 13 autoimmune autoimmune JJ en-wikipedia-org-9224 743 14 diseases disease NNS en-wikipedia-org-9224 743 15 " " '' en-wikipedia-org-9224 743 16 . . . en-wikipedia-org-9224 744 1 Endocrine Endocrine NNP en-wikipedia-org-9224 744 2 Reviews Reviews NNPS en-wikipedia-org-9224 744 3 . . . en-wikipedia-org-9224 745 1 14 14 CD en-wikipedia-org-9224 745 2 ( ( -LRB- en-wikipedia-org-9224 745 3 5 5 CD en-wikipedia-org-9224 745 4 ) ) -RRB- en-wikipedia-org-9224 745 5 : : : en-wikipedia-org-9224 745 6 539–63 539–63 CD en-wikipedia-org-9224 745 7 . . . en-wikipedia-org-9224 746 1 doi:10.1210 doi:10.1210 NNP en-wikipedia-org-9224 746 2 / / SYM en-wikipedia-org-9224 746 3 edrv-14 edrv-14 NNP en-wikipedia-org-9224 746 4 - - HYPH en-wikipedia-org-9224 746 5 5 5 CD en-wikipedia-org-9224 746 6 - - SYM en-wikipedia-org-9224 746 7 539 539 CD en-wikipedia-org-9224 746 8 . . . en-wikipedia-org-9224 747 1 PMID PMID NNP en-wikipedia-org-9224 747 2   _SP en-wikipedia-org-9224 747 3 8262005 8262005 CD en-wikipedia-org-9224 747 4 . . . en-wikipedia-org-9224 748 1 ^ ^ NNP en-wikipedia-org-9224 748 2 Kroemer Kroemer NNP en-wikipedia-org-9224 748 3 G G NNP en-wikipedia-org-9224 748 4 , , , en-wikipedia-org-9224 748 5 Brezinschek Brezinschek NNP en-wikipedia-org-9224 748 6 HP HP NNP en-wikipedia-org-9224 748 7 , , , en-wikipedia-org-9224 748 8 Faessler Faessler NNP en-wikipedia-org-9224 748 9 R R NNP en-wikipedia-org-9224 748 10 , , , en-wikipedia-org-9224 748 11 Schauenstein Schauenstein NNP en-wikipedia-org-9224 748 12 K K NNP en-wikipedia-org-9224 748 13 , , , en-wikipedia-org-9224 748 14 Wick Wick NNP en-wikipedia-org-9224 748 15 G G NNP en-wikipedia-org-9224 748 16 ( ( -LRB- en-wikipedia-org-9224 748 17 June June NNP en-wikipedia-org-9224 748 18 1988 1988 CD en-wikipedia-org-9224 748 19 ) ) -RRB- en-wikipedia-org-9224 748 20 . . . en-wikipedia-org-9224 749 1 " " `` en-wikipedia-org-9224 749 2 Physiology physiology NN en-wikipedia-org-9224 749 3 and and CC en-wikipedia-org-9224 749 4 pathology pathology NN en-wikipedia-org-9224 749 5 of of IN en-wikipedia-org-9224 749 6 an an DT en-wikipedia-org-9224 749 7 immunoendocrine immunoendocrine JJ en-wikipedia-org-9224 749 8 feedback feedback NN en-wikipedia-org-9224 749 9 loop loop NN en-wikipedia-org-9224 749 10 " " '' en-wikipedia-org-9224 749 11 . . . en-wikipedia-org-9224 750 1 Immunology immunology NN en-wikipedia-org-9224 750 2 Today today NN en-wikipedia-org-9224 750 3 . . . en-wikipedia-org-9224 751 1 9 9 CD en-wikipedia-org-9224 751 2 ( ( -LRB- en-wikipedia-org-9224 751 3 6 6 CD en-wikipedia-org-9224 751 4 ) ) -RRB- en-wikipedia-org-9224 751 5 : : : en-wikipedia-org-9224 751 6 163–5 163–5 CD en-wikipedia-org-9224 751 7 . . . en-wikipedia-org-9224 752 1 doi:10.1016/0167 doi:10.1016/0167 NNP en-wikipedia-org-9224 752 2 - - : en-wikipedia-org-9224 752 3 5699(88)91289 5699(88)91289 NNP en-wikipedia-org-9224 752 4 - - HYPH en-wikipedia-org-9224 752 5 3 3 CD en-wikipedia-org-9224 752 6 . . . en-wikipedia-org-9224 753 1 PMID PMID NNP en-wikipedia-org-9224 753 2   _SP en-wikipedia-org-9224 753 3 3256322 3256322 CD en-wikipedia-org-9224 753 4 . . . en-wikipedia-org-9224 754 1 ^ ^ NFP en-wikipedia-org-9224 754 2 Trakhtenberg Trakhtenberg NNP en-wikipedia-org-9224 754 3 EF EF NNP en-wikipedia-org-9224 754 4 , , , en-wikipedia-org-9224 754 5 Goldberg Goldberg NNP en-wikipedia-org-9224 754 6 JL JL NNP en-wikipedia-org-9224 754 7 ( ( -LRB- en-wikipedia-org-9224 754 8 October October NNP en-wikipedia-org-9224 754 9 2011 2011 CD en-wikipedia-org-9224 754 10 ) ) -RRB- en-wikipedia-org-9224 754 11 . . . en-wikipedia-org-9224 755 1 " " `` en-wikipedia-org-9224 755 2 Immunology immunology NN en-wikipedia-org-9224 755 3 . . . en-wikipedia-org-9224 756 1 Neuroimmune neuroimmune JJ en-wikipedia-org-9224 756 2 communication communication NN en-wikipedia-org-9224 756 3 " " '' en-wikipedia-org-9224 756 4 . . . en-wikipedia-org-9224 757 1 Science science NN en-wikipedia-org-9224 757 2 . . . en-wikipedia-org-9224 758 1 334 334 CD en-wikipedia-org-9224 758 2 ( ( -LRB- en-wikipedia-org-9224 758 3 6052 6052 CD en-wikipedia-org-9224 758 4 ) ) -RRB- en-wikipedia-org-9224 758 5 : : : en-wikipedia-org-9224 758 6 47–8 47–8 LS en-wikipedia-org-9224 758 7 . . . en-wikipedia-org-9224 759 1 Bibcode:2011Sci Bibcode:2011Sci NFP en-wikipedia-org-9224 759 2 ... ... NFP en-wikipedia-org-9224 759 3 334 334 CD en-wikipedia-org-9224 759 4 ... ... SYM en-wikipedia-org-9224 759 5 47T. 47t. CD en-wikipedia-org-9224 760 1 doi:10.1126 doi:10.1126 VB en-wikipedia-org-9224 760 2 / / SYM en-wikipedia-org-9224 760 3 science.1213099 science.1213099 NN en-wikipedia-org-9224 760 4 . . . en-wikipedia-org-9224 761 1 PMID PMID NNP en-wikipedia-org-9224 761 2   _SP en-wikipedia-org-9224 761 3 21980100 21980100 CD en-wikipedia-org-9224 761 4 . . . en-wikipedia-org-9224 762 1 S2CID S2CID NNS en-wikipedia-org-9224 762 2   _SP en-wikipedia-org-9224 762 3 36504684 36504684 CD en-wikipedia-org-9224 762 4 . . . en-wikipedia-org-9224 763 1 ^ ^ NNP en-wikipedia-org-9224 763 2 Veiga Veiga NNP en-wikipedia-org-9224 763 3 - - HYPH en-wikipedia-org-9224 763 4 Fernandes Fernandes NNP en-wikipedia-org-9224 763 5 H H NNP en-wikipedia-org-9224 763 6 , , , en-wikipedia-org-9224 763 7 Mucida Mucida NNP en-wikipedia-org-9224 763 8 D D NNP en-wikipedia-org-9224 763 9 ( ( -LRB- en-wikipedia-org-9224 763 10 May May NNP en-wikipedia-org-9224 763 11 2016 2016 CD en-wikipedia-org-9224 763 12 ) ) -RRB- en-wikipedia-org-9224 763 13 . . . en-wikipedia-org-9224 764 1 " " `` en-wikipedia-org-9224 764 2 Neuro Neuro NNP en-wikipedia-org-9224 764 3 - - HYPH en-wikipedia-org-9224 764 4 Immune Immune NNP en-wikipedia-org-9224 764 5 Interactions Interactions NNPS en-wikipedia-org-9224 764 6 at at IN en-wikipedia-org-9224 764 7 Barrier Barrier NNP en-wikipedia-org-9224 764 8 Surfaces Surfaces NNP en-wikipedia-org-9224 764 9 " " '' en-wikipedia-org-9224 764 10 . . . en-wikipedia-org-9224 765 1 Cell cell NN en-wikipedia-org-9224 765 2 . . . en-wikipedia-org-9224 766 1 165 165 CD en-wikipedia-org-9224 766 2 ( ( -LRB- en-wikipedia-org-9224 766 3 4 4 CD en-wikipedia-org-9224 766 4 ) ) -RRB- en-wikipedia-org-9224 766 5 : : : en-wikipedia-org-9224 766 6 801–11 801–11 CD en-wikipedia-org-9224 766 7 . . . en-wikipedia-org-9224 767 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 767 2 / / SYM en-wikipedia-org-9224 767 3 j.cell.2016.04.041 j.cell.2016.04.041 XX en-wikipedia-org-9224 767 4 . . . en-wikipedia-org-9224 768 1 PMC PMC NNP en-wikipedia-org-9224 768 2   _SP en-wikipedia-org-9224 768 3 4871617 4871617 CD en-wikipedia-org-9224 768 4 . . . en-wikipedia-org-9224 769 1 PMID PMID NNP en-wikipedia-org-9224 769 2   _SP en-wikipedia-org-9224 769 3 27153494 27153494 CD en-wikipedia-org-9224 769 4 . . . en-wikipedia-org-9224 770 1 ^ ^ FW en-wikipedia-org-9224 770 2 " " `` en-wikipedia-org-9224 770 3 Neuroimmune neuroimmune JJ en-wikipedia-org-9224 770 4 communication communication NN en-wikipedia-org-9224 770 5 " " '' en-wikipedia-org-9224 770 6 . . . en-wikipedia-org-9224 771 1 Nature nature NN en-wikipedia-org-9224 771 2 Neuroscience Neuroscience NNP en-wikipedia-org-9224 771 3 . . . en-wikipedia-org-9224 772 1 20 20 CD en-wikipedia-org-9224 772 2 ( ( -LRB- en-wikipedia-org-9224 772 3 2 2 CD en-wikipedia-org-9224 772 4 ) ) -RRB- en-wikipedia-org-9224 772 5 : : : en-wikipedia-org-9224 772 6 127 127 CD en-wikipedia-org-9224 772 7 . . . en-wikipedia-org-9224 773 1 February February NNP en-wikipedia-org-9224 773 2 2017 2017 CD en-wikipedia-org-9224 773 3 . . . en-wikipedia-org-9224 773 4 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 773 5 / / SYM en-wikipedia-org-9224 773 6 nn.4496 nn.4496 NNP en-wikipedia-org-9224 773 7 . . . en-wikipedia-org-9224 774 1 PMID PMID NNP en-wikipedia-org-9224 774 2   _SP en-wikipedia-org-9224 774 3 28092662 28092662 CD en-wikipedia-org-9224 774 4 . . . en-wikipedia-org-9224 775 1 ^ ^ NNP en-wikipedia-org-9224 775 2 Wilcox Wilcox NNP en-wikipedia-org-9224 775 3 SM SM NNP en-wikipedia-org-9224 775 4 , , , en-wikipedia-org-9224 775 5 Arora Arora NNP en-wikipedia-org-9224 775 6 H H NNP en-wikipedia-org-9224 775 7 , , , en-wikipedia-org-9224 775 8 Munro Munro NNP en-wikipedia-org-9224 775 9 L L NNP en-wikipedia-org-9224 775 10 , , , en-wikipedia-org-9224 775 11 Xin Xin NNP en-wikipedia-org-9224 775 12 J J NNP en-wikipedia-org-9224 775 13 , , , en-wikipedia-org-9224 775 14 Fenninger Fenninger NNP en-wikipedia-org-9224 775 15 F F NNP en-wikipedia-org-9224 775 16 , , , en-wikipedia-org-9224 775 17 Johnson Johnson NNP en-wikipedia-org-9224 775 18 LA LA NNP en-wikipedia-org-9224 775 19 , , , en-wikipedia-org-9224 775 20 Pfeifer Pfeifer NNP en-wikipedia-org-9224 775 21 CG CG NNP en-wikipedia-org-9224 775 22 , , , en-wikipedia-org-9224 775 23 Choi Choi NNP en-wikipedia-org-9224 775 24 KB KB NNP en-wikipedia-org-9224 775 25 , , , en-wikipedia-org-9224 775 26 Hou Hou NNP en-wikipedia-org-9224 775 27 J J NNP en-wikipedia-org-9224 775 28 , , , en-wikipedia-org-9224 775 29 Hoodless Hoodless NNP en-wikipedia-org-9224 775 30 PA PA NNP en-wikipedia-org-9224 775 31 , , , en-wikipedia-org-9224 775 32 Jefferies Jefferies NNP en-wikipedia-org-9224 775 33 WA WA NNP en-wikipedia-org-9224 775 34 ( ( -LRB- en-wikipedia-org-9224 775 35 2017 2017 CD en-wikipedia-org-9224 775 36 ) ) -RRB- en-wikipedia-org-9224 775 37 . . . en-wikipedia-org-9224 776 1 " " `` en-wikipedia-org-9224 776 2 The the DT en-wikipedia-org-9224 776 3 role role NN en-wikipedia-org-9224 776 4 of of IN en-wikipedia-org-9224 776 5 the the DT en-wikipedia-org-9224 776 6 innate innate JJ en-wikipedia-org-9224 776 7 immune immune JJ en-wikipedia-org-9224 776 8 response response NN en-wikipedia-org-9224 776 9 regulatory regulatory JJ en-wikipedia-org-9224 776 10 gene gene NN en-wikipedia-org-9224 776 11 ABCF1 ABCF1 NNS en-wikipedia-org-9224 776 12 in in IN en-wikipedia-org-9224 776 13 mammalian mammalian JJ en-wikipedia-org-9224 776 14 embryogenesis embryogenesis NN en-wikipedia-org-9224 776 15 and and CC en-wikipedia-org-9224 776 16 development development NN en-wikipedia-org-9224 776 17 " " '' en-wikipedia-org-9224 776 18 . . . en-wikipedia-org-9224 777 1 PLOS PLOS NNP en-wikipedia-org-9224 777 2 ONE one CD en-wikipedia-org-9224 777 3 . . . en-wikipedia-org-9224 778 1 12 12 CD en-wikipedia-org-9224 778 2 ( ( -LRB- en-wikipedia-org-9224 778 3 5 5 CD en-wikipedia-org-9224 778 4 ) ) -RRB- en-wikipedia-org-9224 778 5 : : : en-wikipedia-org-9224 778 6 e0175918 e0175918 NN en-wikipedia-org-9224 778 7 . . . en-wikipedia-org-9224 779 1 Bibcode:2017PLoSO bibcode:2017ploso NN en-wikipedia-org-9224 779 2 .. .. NFP en-wikipedia-org-9224 779 3 1275918W. 1275918w. CD en-wikipedia-org-9224 780 1 doi:10.1371 doi:10.1371 NNP en-wikipedia-org-9224 780 2 / / SYM en-wikipedia-org-9224 780 3 journal.pone.0175918 journal.pone.0175918 NNP en-wikipedia-org-9224 780 4 . . . en-wikipedia-org-9224 781 1 PMC PMC NNP en-wikipedia-org-9224 781 2   _SP en-wikipedia-org-9224 781 3 5438103 5438103 CD en-wikipedia-org-9224 781 4 . . . en-wikipedia-org-9224 782 1 PMID PMID NNP en-wikipedia-org-9224 782 2   _SP en-wikipedia-org-9224 782 3 28542262 28542262 CD en-wikipedia-org-9224 782 4 . . . en-wikipedia-org-9224 783 1 ^ ^ NNP en-wikipedia-org-9224 783 2 Wira Wira NNP en-wikipedia-org-9224 783 3 , , , en-wikipedia-org-9224 783 4 Crane Crane NNP en-wikipedia-org-9224 783 5 - - HYPH en-wikipedia-org-9224 783 6 Godreau Godreau NNP en-wikipedia-org-9224 783 7 & & CC en-wikipedia-org-9224 783 8 Grant Grant NNP en-wikipedia-org-9224 783 9 2004 2004 CD en-wikipedia-org-9224 783 10 , , , en-wikipedia-org-9224 783 11 Chapter chapter NN en-wikipedia-org-9224 783 12 : : . en-wikipedia-org-9224 783 13 Endocrine endocrine VB en-wikipedia-org-9224 783 14 regulation regulation NN en-wikipedia-org-9224 783 15 of of IN en-wikipedia-org-9224 783 16 the the DT en-wikipedia-org-9224 783 17 mucosal mucosal JJ en-wikipedia-org-9224 783 18 immune immune JJ en-wikipedia-org-9224 783 19 system system NN en-wikipedia-org-9224 783 20 in in IN en-wikipedia-org-9224 783 21 the the DT en-wikipedia-org-9224 783 22 female female JJ en-wikipedia-org-9224 783 23 reproductive reproductive JJ en-wikipedia-org-9224 783 24 tract tract NN en-wikipedia-org-9224 783 25 . . . en-wikipedia-org-9224 784 1 ^ ^ NNP en-wikipedia-org-9224 784 2 Lang Lang NNP en-wikipedia-org-9224 784 3 TJ TJ NNP en-wikipedia-org-9224 784 4 ( ( -LRB- en-wikipedia-org-9224 784 5 December December NNP en-wikipedia-org-9224 784 6 2004 2004 CD en-wikipedia-org-9224 784 7 ) ) -RRB- en-wikipedia-org-9224 784 8 . . . en-wikipedia-org-9224 785 1 " " `` en-wikipedia-org-9224 785 2 Estrogen Estrogen NNP en-wikipedia-org-9224 785 3 as as IN en-wikipedia-org-9224 785 4 an an DT en-wikipedia-org-9224 785 5 immunomodulator immunomodulator NN en-wikipedia-org-9224 785 6 " " '' en-wikipedia-org-9224 785 7 . . . en-wikipedia-org-9224 786 1 Clinical Clinical NNP en-wikipedia-org-9224 786 2 Immunology Immunology NNP en-wikipedia-org-9224 786 3 . . . en-wikipedia-org-9224 787 1 113 113 CD en-wikipedia-org-9224 787 2 ( ( -LRB- en-wikipedia-org-9224 787 3 3 3 CD en-wikipedia-org-9224 787 4 ) ) -RRB- en-wikipedia-org-9224 787 5 : : : en-wikipedia-org-9224 787 6 224–30 224–30 CD en-wikipedia-org-9224 787 7 . . . en-wikipedia-org-9224 788 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 788 2 / / SYM en-wikipedia-org-9224 788 3 j.clim.2004.05.011 j.clim.2004.05.011 JJ en-wikipedia-org-9224 788 4 . . . en-wikipedia-org-9224 789 1 PMID PMID NNP en-wikipedia-org-9224 789 2   _SP en-wikipedia-org-9224 789 3 15507385 15507385 CD en-wikipedia-org-9224 789 4 . . . en-wikipedia-org-9224 790 1 Moriyama Moriyama NNP en-wikipedia-org-9224 790 2 A A NNP en-wikipedia-org-9224 790 3 , , , en-wikipedia-org-9224 790 4 Shimoya Shimoya NNP en-wikipedia-org-9224 790 5 K K NNP en-wikipedia-org-9224 790 6 , , , en-wikipedia-org-9224 790 7 Ogata Ogata NNP en-wikipedia-org-9224 790 8 I I NNP en-wikipedia-org-9224 790 9 , , , en-wikipedia-org-9224 790 10 Kimura Kimura NNP en-wikipedia-org-9224 790 11 T T NNP en-wikipedia-org-9224 790 12 , , , en-wikipedia-org-9224 790 13 Nakamura Nakamura NNP en-wikipedia-org-9224 790 14 T T NNP en-wikipedia-org-9224 790 15 , , , en-wikipedia-org-9224 790 16 Wada Wada NNP en-wikipedia-org-9224 790 17 H H NNP en-wikipedia-org-9224 790 18 , , , en-wikipedia-org-9224 790 19 Ohashi Ohashi NNP en-wikipedia-org-9224 790 20 K K NNP en-wikipedia-org-9224 790 21 , , , en-wikipedia-org-9224 790 22 Azuma Azuma NNP en-wikipedia-org-9224 790 23 C C NNP en-wikipedia-org-9224 790 24 , , , en-wikipedia-org-9224 790 25 Saji Saji NNP en-wikipedia-org-9224 790 26 F F NNP en-wikipedia-org-9224 790 27 , , , en-wikipedia-org-9224 790 28 Murata Murata NNP en-wikipedia-org-9224 790 29 Y Y NNP en-wikipedia-org-9224 790 30 ( ( -LRB- en-wikipedia-org-9224 790 31 July July NNP en-wikipedia-org-9224 790 32 1999 1999 CD en-wikipedia-org-9224 790 33 ) ) -RRB- en-wikipedia-org-9224 790 34 . . . en-wikipedia-org-9224 791 1 " " `` en-wikipedia-org-9224 791 2 Secretory secretory RB en-wikipedia-org-9224 791 3 leukocyte leukocyte RB en-wikipedia-org-9224 791 4 protease protease NN en-wikipedia-org-9224 791 5 inhibitor inhibitor NN en-wikipedia-org-9224 791 6 ( ( -LRB- en-wikipedia-org-9224 791 7 SLPI SLPI NNP en-wikipedia-org-9224 791 8 ) ) -RRB- en-wikipedia-org-9224 791 9 concentrations concentration NNS en-wikipedia-org-9224 791 10 in in IN en-wikipedia-org-9224 791 11 cervical cervical JJ en-wikipedia-org-9224 791 12 mucus mucus NN en-wikipedia-org-9224 791 13 of of IN en-wikipedia-org-9224 791 14 women woman NNS en-wikipedia-org-9224 791 15 with with IN en-wikipedia-org-9224 791 16 normal normal JJ en-wikipedia-org-9224 791 17 menstrual menstrual JJ en-wikipedia-org-9224 791 18 cycle cycle NN en-wikipedia-org-9224 791 19 " " '' en-wikipedia-org-9224 791 20 . . . en-wikipedia-org-9224 792 1 Molecular Molecular NNP en-wikipedia-org-9224 792 2 Human Human NNP en-wikipedia-org-9224 792 3 Reproduction Reproduction NNP en-wikipedia-org-9224 792 4 . . . en-wikipedia-org-9224 793 1 5 5 CD en-wikipedia-org-9224 793 2 ( ( -LRB- en-wikipedia-org-9224 793 3 7 7 CD en-wikipedia-org-9224 793 4 ) ) -RRB- en-wikipedia-org-9224 793 5 : : : en-wikipedia-org-9224 793 6 656–61 656–61 CD en-wikipedia-org-9224 793 7 . . . en-wikipedia-org-9224 794 1 doi:10.1093 doi:10.1093 NNP en-wikipedia-org-9224 794 2 / / SYM en-wikipedia-org-9224 794 3 molehr/5.7.656 molehr/5.7.656 NNP en-wikipedia-org-9224 794 4 . . . en-wikipedia-org-9224 795 1 PMID PMID NNP en-wikipedia-org-9224 795 2   _SP en-wikipedia-org-9224 795 3 10381821 10381821 CD en-wikipedia-org-9224 795 4 . . . en-wikipedia-org-9224 796 1 Cutolo Cutolo NNP en-wikipedia-org-9224 796 2 M M NNP en-wikipedia-org-9224 796 3 , , , en-wikipedia-org-9224 796 4 Sulli Sulli NNP en-wikipedia-org-9224 796 5 A A NNP en-wikipedia-org-9224 796 6 , , , en-wikipedia-org-9224 796 7 Capellino Capellino NNP en-wikipedia-org-9224 796 8 S S NNP en-wikipedia-org-9224 796 9 , , , en-wikipedia-org-9224 796 10 Villaggio Villaggio NNP en-wikipedia-org-9224 796 11 B B NNP en-wikipedia-org-9224 796 12 , , , en-wikipedia-org-9224 796 13 Montagna Montagna NNP en-wikipedia-org-9224 796 14 P P NNP en-wikipedia-org-9224 796 15 , , , en-wikipedia-org-9224 796 16 Seriolo Seriolo NNP en-wikipedia-org-9224 796 17 B B NNP en-wikipedia-org-9224 796 18 , , , en-wikipedia-org-9224 796 19 Straub Straub NNP en-wikipedia-org-9224 796 20 RH RH NNP en-wikipedia-org-9224 796 21 ( ( -LRB- en-wikipedia-org-9224 796 22 2004 2004 CD en-wikipedia-org-9224 796 23 ) ) -RRB- en-wikipedia-org-9224 796 24 . . . en-wikipedia-org-9224 797 1 " " `` en-wikipedia-org-9224 797 2 Sex sex NN en-wikipedia-org-9224 797 3 hormones hormone NNS en-wikipedia-org-9224 797 4 influence influence NN en-wikipedia-org-9224 797 5 on on IN en-wikipedia-org-9224 797 6 the the DT en-wikipedia-org-9224 797 7 immune immune JJ en-wikipedia-org-9224 797 8 system system NN en-wikipedia-org-9224 797 9 : : : en-wikipedia-org-9224 797 10 basic basic JJ en-wikipedia-org-9224 797 11 and and CC en-wikipedia-org-9224 797 12 clinical clinical JJ en-wikipedia-org-9224 797 13 aspects aspect NNS en-wikipedia-org-9224 797 14 in in IN en-wikipedia-org-9224 797 15 autoimmunity autoimmunity NN en-wikipedia-org-9224 797 16 " " '' en-wikipedia-org-9224 797 17 . . . en-wikipedia-org-9224 798 1 Lupus Lupus NNP en-wikipedia-org-9224 798 2 . . . en-wikipedia-org-9224 799 1 13 13 CD en-wikipedia-org-9224 799 2 ( ( -LRB- en-wikipedia-org-9224 799 3 9 9 CD en-wikipedia-org-9224 799 4 ) ) -RRB- en-wikipedia-org-9224 799 5 : : : en-wikipedia-org-9224 799 6 635–38 635–38 CD en-wikipedia-org-9224 799 7 . . . en-wikipedia-org-9224 800 1 doi:10.1191/0961203304lu1094oa doi:10.1191/0961203304lu1094oa NNP en-wikipedia-org-9224 800 2 . . . en-wikipedia-org-9224 801 1 PMID PMID NNP en-wikipedia-org-9224 801 2   _SP en-wikipedia-org-9224 801 3 15485092 15485092 CD en-wikipedia-org-9224 801 4 . . . en-wikipedia-org-9224 802 1 S2CID S2CID NNS en-wikipedia-org-9224 802 2   _SP en-wikipedia-org-9224 802 3 23941507 23941507 CD en-wikipedia-org-9224 802 4 . . . en-wikipedia-org-9224 803 1 King King NNP en-wikipedia-org-9224 803 2 AE AE NNP en-wikipedia-org-9224 803 3 , , , en-wikipedia-org-9224 803 4 Critchley Critchley NNP en-wikipedia-org-9224 803 5 HO HO NNP en-wikipedia-org-9224 803 6 , , , en-wikipedia-org-9224 803 7 Kelly Kelly NNP en-wikipedia-org-9224 803 8 RW RW NNP en-wikipedia-org-9224 803 9 ( ( -LRB- en-wikipedia-org-9224 803 10 February February NNP en-wikipedia-org-9224 803 11 2000 2000 CD en-wikipedia-org-9224 803 12 ) ) -RRB- en-wikipedia-org-9224 803 13 . . . en-wikipedia-org-9224 804 1 " " `` en-wikipedia-org-9224 804 2 Presence presence NN en-wikipedia-org-9224 804 3 of of IN en-wikipedia-org-9224 804 4 secretory secretory NN en-wikipedia-org-9224 804 5 leukocyte leukocyte VBG en-wikipedia-org-9224 804 6 protease protease NN en-wikipedia-org-9224 804 7 inhibitor inhibitor NN en-wikipedia-org-9224 804 8 in in IN en-wikipedia-org-9224 804 9 human human JJ en-wikipedia-org-9224 804 10 endometrium endometrium NN en-wikipedia-org-9224 804 11 and and CC en-wikipedia-org-9224 804 12 first first JJ en-wikipedia-org-9224 804 13 trimester trimester NN en-wikipedia-org-9224 804 14 decidua decidua NN en-wikipedia-org-9224 804 15 suggests suggest VBZ en-wikipedia-org-9224 804 16 an an DT en-wikipedia-org-9224 804 17 antibacterial antibacterial JJ en-wikipedia-org-9224 804 18 protective protective JJ en-wikipedia-org-9224 804 19 role role NN en-wikipedia-org-9224 804 20 " " '' en-wikipedia-org-9224 804 21 . . . en-wikipedia-org-9224 805 1 Molecular Molecular NNP en-wikipedia-org-9224 805 2 Human Human NNP en-wikipedia-org-9224 805 3 Reproduction Reproduction NNP en-wikipedia-org-9224 805 4 . . . en-wikipedia-org-9224 806 1 6 6 CD en-wikipedia-org-9224 806 2 ( ( -LRB- en-wikipedia-org-9224 806 3 2 2 CD en-wikipedia-org-9224 806 4 ) ) -RRB- en-wikipedia-org-9224 806 5 : : : en-wikipedia-org-9224 806 6 191–96 191–96 CD en-wikipedia-org-9224 806 7 . . . en-wikipedia-org-9224 807 1 doi:10.1093 doi:10.1093 NNP en-wikipedia-org-9224 807 2 / / SYM en-wikipedia-org-9224 807 3 molehr/6.2.191 molehr/6.2.191 NNP en-wikipedia-org-9224 807 4 . . . en-wikipedia-org-9224 808 1 PMID PMID NNP en-wikipedia-org-9224 808 2   _SP en-wikipedia-org-9224 808 3 10655462 10655462 CD en-wikipedia-org-9224 808 4 . . . en-wikipedia-org-9224 809 1 ^ ^ NFP en-wikipedia-org-9224 809 2 Fimmel Fimmel NNP en-wikipedia-org-9224 809 3 S S NNP en-wikipedia-org-9224 809 4 , , , en-wikipedia-org-9224 809 5 Zouboulis Zouboulis NNP en-wikipedia-org-9224 809 6 CC CC NNP en-wikipedia-org-9224 809 7 ( ( -LRB- en-wikipedia-org-9224 809 8 2005 2005 CD en-wikipedia-org-9224 809 9 ) ) -RRB- en-wikipedia-org-9224 809 10 . . . en-wikipedia-org-9224 810 1 " " `` en-wikipedia-org-9224 810 2 Influence influence NN en-wikipedia-org-9224 810 3 of of IN en-wikipedia-org-9224 810 4 physiological physiological JJ en-wikipedia-org-9224 810 5 androgen androgen JJ en-wikipedia-org-9224 810 6 levels level NNS en-wikipedia-org-9224 810 7 on on IN en-wikipedia-org-9224 810 8 wound wind VBN en-wikipedia-org-9224 810 9 healing healing NN en-wikipedia-org-9224 810 10 and and CC en-wikipedia-org-9224 810 11 immune immune JJ en-wikipedia-org-9224 810 12 status status NN en-wikipedia-org-9224 810 13 in in IN en-wikipedia-org-9224 810 14 men man NNS en-wikipedia-org-9224 810 15 " " '' en-wikipedia-org-9224 810 16 . . . en-wikipedia-org-9224 811 1 The the DT en-wikipedia-org-9224 811 2 Aging age VBG en-wikipedia-org-9224 811 3 Male male NN en-wikipedia-org-9224 811 4 . . . en-wikipedia-org-9224 812 1 8 8 CD en-wikipedia-org-9224 812 2 ( ( -LRB- en-wikipedia-org-9224 812 3 3–4 3–4 CD en-wikipedia-org-9224 812 4 ) ) -RRB- en-wikipedia-org-9224 812 5 : : : en-wikipedia-org-9224 812 6 166–74 166–74 CD en-wikipedia-org-9224 812 7 . . . en-wikipedia-org-9224 813 1 doi:10.1080/13685530500233847 doi:10.1080/13685530500233847 NN en-wikipedia-org-9224 813 2 . . . en-wikipedia-org-9224 814 1 PMID PMID NNP en-wikipedia-org-9224 814 2   _SP en-wikipedia-org-9224 814 3 16390741 16390741 CD en-wikipedia-org-9224 814 4 . . . en-wikipedia-org-9224 815 1 S2CID S2CID NNS en-wikipedia-org-9224 815 2   _SP en-wikipedia-org-9224 815 3 1021367 1021367 CD en-wikipedia-org-9224 815 4 . . . en-wikipedia-org-9224 816 1 ^ ^ NFP en-wikipedia-org-9224 816 2 Dorshkind Dorshkind NNP en-wikipedia-org-9224 816 3 K K NNP en-wikipedia-org-9224 816 4 , , , en-wikipedia-org-9224 816 5 Horseman Horseman NNP en-wikipedia-org-9224 816 6 ND ND NNP en-wikipedia-org-9224 816 7 ( ( -LRB- en-wikipedia-org-9224 816 8 June June NNP en-wikipedia-org-9224 816 9 2000 2000 CD en-wikipedia-org-9224 816 10 ) ) -RRB- en-wikipedia-org-9224 816 11 . . . en-wikipedia-org-9224 817 1 " " `` en-wikipedia-org-9224 817 2 The the DT en-wikipedia-org-9224 817 3 roles role NNS en-wikipedia-org-9224 817 4 of of IN en-wikipedia-org-9224 817 5 prolactin prolactin NN en-wikipedia-org-9224 817 6 , , , en-wikipedia-org-9224 817 7 growth growth NN en-wikipedia-org-9224 817 8 hormone hormone NN en-wikipedia-org-9224 817 9 , , , en-wikipedia-org-9224 817 10 insulin insulin NN en-wikipedia-org-9224 817 11 - - HYPH en-wikipedia-org-9224 817 12 like like JJ en-wikipedia-org-9224 817 13 growth growth NN en-wikipedia-org-9224 817 14 factor factor NN en-wikipedia-org-9224 817 15 - - : en-wikipedia-org-9224 817 16 I -PRON- PRP en-wikipedia-org-9224 817 17 , , , en-wikipedia-org-9224 817 18 and and CC en-wikipedia-org-9224 817 19 thyroid thyroid NNP en-wikipedia-org-9224 817 20 hormones hormones NNPS en-wikipedia-org-9224 817 21 in in IN en-wikipedia-org-9224 817 22 lymphocyte lymphocyte NNP en-wikipedia-org-9224 817 23 development development NN en-wikipedia-org-9224 817 24 and and CC en-wikipedia-org-9224 817 25 function function NN en-wikipedia-org-9224 817 26 : : : en-wikipedia-org-9224 817 27 insights insight NNS en-wikipedia-org-9224 817 28 from from IN en-wikipedia-org-9224 817 29 genetic genetic JJ en-wikipedia-org-9224 817 30 models model NNS en-wikipedia-org-9224 817 31 of of IN en-wikipedia-org-9224 817 32 hormone hormone NN en-wikipedia-org-9224 817 33 and and CC en-wikipedia-org-9224 817 34 hormone hormone NN en-wikipedia-org-9224 817 35 receptor receptor NN en-wikipedia-org-9224 817 36 deficiency deficiency NN en-wikipedia-org-9224 817 37 " " '' en-wikipedia-org-9224 817 38 . . . en-wikipedia-org-9224 818 1 Endocrine Endocrine NNP en-wikipedia-org-9224 818 2 Reviews Reviews NNPS en-wikipedia-org-9224 818 3 . . . en-wikipedia-org-9224 819 1 21 21 CD en-wikipedia-org-9224 819 2 ( ( -LRB- en-wikipedia-org-9224 819 3 3 3 CD en-wikipedia-org-9224 819 4 ) ) -RRB- en-wikipedia-org-9224 819 5 : : : en-wikipedia-org-9224 819 6 292–312 292–312 CD en-wikipedia-org-9224 819 7 . . . en-wikipedia-org-9224 820 1 doi:10.1210 doi:10.1210 NNP en-wikipedia-org-9224 820 2 / / SYM en-wikipedia-org-9224 820 3 er.21.3.292 er.21.3.292 NN en-wikipedia-org-9224 820 4 . . . en-wikipedia-org-9224 821 1 PMID PMID NNP en-wikipedia-org-9224 821 2   _SP en-wikipedia-org-9224 821 3 10857555 10857555 CD en-wikipedia-org-9224 821 4 . . . en-wikipedia-org-9224 822 1 ^ ^ NNP en-wikipedia-org-9224 822 2 Nagpal Nagpal NNP en-wikipedia-org-9224 822 3 S S NNP en-wikipedia-org-9224 822 4 , , , en-wikipedia-org-9224 822 5 Na Na NNP en-wikipedia-org-9224 822 6 S S NNP en-wikipedia-org-9224 822 7 , , , en-wikipedia-org-9224 822 8 Rathnachalam Rathnachalam NNP en-wikipedia-org-9224 822 9 R R NNP en-wikipedia-org-9224 822 10 ( ( -LRB- en-wikipedia-org-9224 822 11 August August NNP en-wikipedia-org-9224 822 12 2005 2005 CD en-wikipedia-org-9224 822 13 ) ) -RRB- en-wikipedia-org-9224 822 14 . . . en-wikipedia-org-9224 823 1 " " `` en-wikipedia-org-9224 823 2 Noncalcemic noncalcemic JJ en-wikipedia-org-9224 823 3 actions action NNS en-wikipedia-org-9224 823 4 of of IN en-wikipedia-org-9224 823 5 vitamin vitamin NN en-wikipedia-org-9224 823 6 D d JJ en-wikipedia-org-9224 823 7 receptor receptor NN en-wikipedia-org-9224 823 8 ligands ligand VBZ en-wikipedia-org-9224 823 9 " " '' en-wikipedia-org-9224 823 10 . . . en-wikipedia-org-9224 824 1 Endocrine Endocrine NNP en-wikipedia-org-9224 824 2 Reviews Reviews NNPS en-wikipedia-org-9224 824 3 . . . en-wikipedia-org-9224 825 1 26 26 CD en-wikipedia-org-9224 825 2 ( ( -LRB- en-wikipedia-org-9224 825 3 5 5 CD en-wikipedia-org-9224 825 4 ) ) -RRB- en-wikipedia-org-9224 825 5 : : : en-wikipedia-org-9224 825 6 662–87 662–87 CD en-wikipedia-org-9224 825 7 . . . en-wikipedia-org-9224 826 1 doi:10.1210 doi:10.1210 NNP en-wikipedia-org-9224 826 2 / / SYM en-wikipedia-org-9224 826 3 er.2004 er.2004 NNP en-wikipedia-org-9224 826 4 - - HYPH en-wikipedia-org-9224 826 5 0002 0002 CD en-wikipedia-org-9224 826 6 . . . en-wikipedia-org-9224 827 1 PMID PMID NNP en-wikipedia-org-9224 827 2   _SP en-wikipedia-org-9224 827 3 15798098 15798098 CD en-wikipedia-org-9224 827 4 . . . en-wikipedia-org-9224 828 1 ^ ^ NNP en-wikipedia-org-9224 828 2 von von NNP en-wikipedia-org-9224 828 3 Essen Essen NNP en-wikipedia-org-9224 828 4 MR MR NNP en-wikipedia-org-9224 828 5 , , , en-wikipedia-org-9224 828 6 Kongsbak Kongsbak NNP en-wikipedia-org-9224 828 7 M M NNP en-wikipedia-org-9224 828 8 , , , en-wikipedia-org-9224 828 9 Schjerling Schjerling NNP en-wikipedia-org-9224 828 10 P P NNP en-wikipedia-org-9224 828 11 , , , en-wikipedia-org-9224 828 12 Olgaard Olgaard NNP en-wikipedia-org-9224 828 13 K K NNP en-wikipedia-org-9224 828 14 , , , en-wikipedia-org-9224 828 15 Odum Odum NNP en-wikipedia-org-9224 828 16 N N NNP en-wikipedia-org-9224 828 17 , , , en-wikipedia-org-9224 828 18 Geisler Geisler NNP en-wikipedia-org-9224 828 19 C C NNP en-wikipedia-org-9224 828 20 ( ( -LRB- en-wikipedia-org-9224 828 21 April April NNP en-wikipedia-org-9224 828 22 2010 2010 CD en-wikipedia-org-9224 828 23 ) ) -RRB- en-wikipedia-org-9224 828 24 . . . en-wikipedia-org-9224 829 1 " " `` en-wikipedia-org-9224 829 2 Vitamin vitamin NN en-wikipedia-org-9224 829 3 D d NN en-wikipedia-org-9224 829 4 controls control NNS en-wikipedia-org-9224 829 5 T T NNP en-wikipedia-org-9224 829 6 cell cell NN en-wikipedia-org-9224 829 7 antigen antigen NN en-wikipedia-org-9224 829 8 receptor receptor NN en-wikipedia-org-9224 829 9 signaling signaling NN en-wikipedia-org-9224 829 10 and and CC en-wikipedia-org-9224 829 11 activation activation NN en-wikipedia-org-9224 829 12 of of IN en-wikipedia-org-9224 829 13 human human JJ en-wikipedia-org-9224 829 14 T t NN en-wikipedia-org-9224 829 15 cells cell NNS en-wikipedia-org-9224 829 16 " " '' en-wikipedia-org-9224 829 17 . . . en-wikipedia-org-9224 830 1 Nature Nature NNP en-wikipedia-org-9224 830 2 Immunology Immunology NNP en-wikipedia-org-9224 830 3 . . . en-wikipedia-org-9224 831 1 11 11 CD en-wikipedia-org-9224 831 2 ( ( -LRB- en-wikipedia-org-9224 831 3 4 4 CD en-wikipedia-org-9224 831 4 ) ) -RRB- en-wikipedia-org-9224 831 5 : : : en-wikipedia-org-9224 831 6 344–49 344–49 CD en-wikipedia-org-9224 831 7 . . . en-wikipedia-org-9224 832 1 doi:10.1038 doi:10.1038 LS en-wikipedia-org-9224 832 2 / / SYM en-wikipedia-org-9224 832 3 ni.1851 ni.1851 NNPS en-wikipedia-org-9224 832 4 . . . en-wikipedia-org-9224 833 1 PMID PMID NNP en-wikipedia-org-9224 833 2   _SP en-wikipedia-org-9224 833 3 20208539 20208539 CD en-wikipedia-org-9224 833 4 . . . en-wikipedia-org-9224 834 1 S2CID S2CID NNS en-wikipedia-org-9224 834 2   _SP en-wikipedia-org-9224 834 3 6119729 6119729 CD en-wikipedia-org-9224 834 4 . . . en-wikipedia-org-9224 835 1 ^ ^ NFP en-wikipedia-org-9224 835 2 Sigmundsdottir sigmundsdottir NN en-wikipedia-org-9224 835 3 H h NN en-wikipedia-org-9224 835 4 , , , en-wikipedia-org-9224 835 5 Pan Pan NNP en-wikipedia-org-9224 835 6 J J NNP en-wikipedia-org-9224 835 7 , , , en-wikipedia-org-9224 835 8 Debes Debes NNP en-wikipedia-org-9224 835 9 GF GF NNP en-wikipedia-org-9224 835 10 , , , en-wikipedia-org-9224 835 11 Alt Alt NNP en-wikipedia-org-9224 835 12 C C NNP en-wikipedia-org-9224 835 13 , , , en-wikipedia-org-9224 835 14 Habtezion Habtezion NNP en-wikipedia-org-9224 835 15 A A NNP en-wikipedia-org-9224 835 16 , , , en-wikipedia-org-9224 835 17 Soler Soler NNP en-wikipedia-org-9224 835 18 D d NN en-wikipedia-org-9224 835 19 , , , en-wikipedia-org-9224 835 20 Butcher butcher NN en-wikipedia-org-9224 835 21 EC EC NNP en-wikipedia-org-9224 835 22 ( ( -LRB- en-wikipedia-org-9224 835 23 March March NNP en-wikipedia-org-9224 835 24 2007 2007 CD en-wikipedia-org-9224 835 25 ) ) -RRB- en-wikipedia-org-9224 835 26 . . . en-wikipedia-org-9224 836 1 " " `` en-wikipedia-org-9224 836 2 DCs dc NNS en-wikipedia-org-9224 836 3 metabolize metabolize VBP en-wikipedia-org-9224 836 4 sunlight sunlight NN en-wikipedia-org-9224 836 5 - - HYPH en-wikipedia-org-9224 836 6 induced induce VBN en-wikipedia-org-9224 836 7 vitamin vitamin NN en-wikipedia-org-9224 836 8 D3 d3 NN en-wikipedia-org-9224 836 9 to to IN en-wikipedia-org-9224 836 10 ' ' `` en-wikipedia-org-9224 836 11 program program VB en-wikipedia-org-9224 836 12 ' ' '' en-wikipedia-org-9224 836 13 T T NNP en-wikipedia-org-9224 836 14 cell cell NN en-wikipedia-org-9224 836 15 attraction attraction NN en-wikipedia-org-9224 836 16 to to IN en-wikipedia-org-9224 836 17 the the DT en-wikipedia-org-9224 836 18 epidermal epidermal JJ en-wikipedia-org-9224 836 19 chemokine chemokine NN en-wikipedia-org-9224 836 20 CCL27 ccl27 NN en-wikipedia-org-9224 836 21 " " '' en-wikipedia-org-9224 836 22 . . . en-wikipedia-org-9224 837 1 Nature Nature NNP en-wikipedia-org-9224 837 2 Immunology Immunology NNP en-wikipedia-org-9224 837 3 . . . en-wikipedia-org-9224 838 1 8 8 CD en-wikipedia-org-9224 838 2 ( ( -LRB- en-wikipedia-org-9224 838 3 3 3 CD en-wikipedia-org-9224 838 4 ) ) -RRB- en-wikipedia-org-9224 838 5 : : : en-wikipedia-org-9224 838 6 285–93 285–93 CD en-wikipedia-org-9224 838 7 . . . en-wikipedia-org-9224 839 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 839 2 / / SYM en-wikipedia-org-9224 839 3 ni1433 ni1433 NNP en-wikipedia-org-9224 839 4 . . . en-wikipedia-org-9224 840 1 PMID PMID NNP en-wikipedia-org-9224 840 2   _SP en-wikipedia-org-9224 840 3 17259988 17259988 CD en-wikipedia-org-9224 840 4 . . . en-wikipedia-org-9224 841 1 S2CID S2CID NNS en-wikipedia-org-9224 841 2   _SP en-wikipedia-org-9224 841 3 9540123 9540123 CD en-wikipedia-org-9224 841 4 . . . en-wikipedia-org-9224 842 1 ^ ^ NNP en-wikipedia-org-9224 842 2 Bryant Bryant NNP en-wikipedia-org-9224 842 3 PA PA NNP en-wikipedia-org-9224 842 4 , , , en-wikipedia-org-9224 842 5 Trinder Trinder NNP en-wikipedia-org-9224 842 6 J J NNP en-wikipedia-org-9224 842 7 , , , en-wikipedia-org-9224 842 8 Curtis Curtis NNP en-wikipedia-org-9224 842 9 N N NNP en-wikipedia-org-9224 842 10 ( ( -LRB- en-wikipedia-org-9224 842 11 June June NNP en-wikipedia-org-9224 842 12 2004 2004 CD en-wikipedia-org-9224 842 13 ) ) -RRB- en-wikipedia-org-9224 842 14 . . . en-wikipedia-org-9224 843 1 " " `` en-wikipedia-org-9224 843 2 Sick sick JJ en-wikipedia-org-9224 843 3 and and CC en-wikipedia-org-9224 843 4 tired tired JJ en-wikipedia-org-9224 843 5 : : : en-wikipedia-org-9224 843 6 Does do VBZ en-wikipedia-org-9224 843 7 sleep sleep VB en-wikipedia-org-9224 843 8 have have VB en-wikipedia-org-9224 843 9 a a DT en-wikipedia-org-9224 843 10 vital vital JJ en-wikipedia-org-9224 843 11 role role NN en-wikipedia-org-9224 843 12 in in IN en-wikipedia-org-9224 843 13 the the DT en-wikipedia-org-9224 843 14 immune immune JJ en-wikipedia-org-9224 843 15 system system NN en-wikipedia-org-9224 843 16 ? ? . en-wikipedia-org-9224 843 17 " " '' en-wikipedia-org-9224 843 18 . . . en-wikipedia-org-9224 844 1 Nature Nature NNP en-wikipedia-org-9224 844 2 Reviews Reviews NNPS en-wikipedia-org-9224 844 3 . . . en-wikipedia-org-9224 845 1 Immunology immunology NN en-wikipedia-org-9224 845 2 . . . en-wikipedia-org-9224 846 1 4 4 CD en-wikipedia-org-9224 846 2 ( ( -LRB- en-wikipedia-org-9224 846 3 6 6 CD en-wikipedia-org-9224 846 4 ) ) -RRB- en-wikipedia-org-9224 846 5 : : : en-wikipedia-org-9224 846 6 457–67 457–67 CD en-wikipedia-org-9224 846 7 . . . en-wikipedia-org-9224 847 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 847 2 / / SYM en-wikipedia-org-9224 847 3 nri1369 nri1369 NNP en-wikipedia-org-9224 847 4 . . . en-wikipedia-org-9224 848 1 PMID PMID NNP en-wikipedia-org-9224 848 2   _SP en-wikipedia-org-9224 848 3 15173834 15173834 CD en-wikipedia-org-9224 848 4 . . . en-wikipedia-org-9224 849 1 S2CID S2CID NNS en-wikipedia-org-9224 849 2   _SP en-wikipedia-org-9224 849 3 29318345 29318345 CD en-wikipedia-org-9224 849 4 . . . en-wikipedia-org-9224 850 1 ^ ^ NNP en-wikipedia-org-9224 850 2 Krueger Krueger NNP en-wikipedia-org-9224 850 3 JM JM NNP en-wikipedia-org-9224 850 4 , , , en-wikipedia-org-9224 850 5 Majde Majde NNP en-wikipedia-org-9224 850 6 JA JA NNP en-wikipedia-org-9224 850 7 ( ( -LRB- en-wikipedia-org-9224 850 8 May May NNP en-wikipedia-org-9224 850 9 2003 2003 CD en-wikipedia-org-9224 850 10 ) ) -RRB- en-wikipedia-org-9224 850 11 . . . en-wikipedia-org-9224 851 1 " " `` en-wikipedia-org-9224 851 2 Humoral humoral JJ en-wikipedia-org-9224 851 3 links link NNS en-wikipedia-org-9224 851 4 between between IN en-wikipedia-org-9224 851 5 sleep sleep NN en-wikipedia-org-9224 851 6 and and CC en-wikipedia-org-9224 851 7 the the DT en-wikipedia-org-9224 851 8 immune immune JJ en-wikipedia-org-9224 851 9 system system NN en-wikipedia-org-9224 851 10 : : : en-wikipedia-org-9224 851 11 research research NN en-wikipedia-org-9224 851 12 issues issue NNS en-wikipedia-org-9224 851 13 " " '' en-wikipedia-org-9224 851 14 . . . en-wikipedia-org-9224 852 1 Annals annal NNS en-wikipedia-org-9224 852 2 of of IN en-wikipedia-org-9224 852 3 the the DT en-wikipedia-org-9224 852 4 New New NNP en-wikipedia-org-9224 852 5 York York NNP en-wikipedia-org-9224 852 6 Academy Academy NNP en-wikipedia-org-9224 852 7 of of IN en-wikipedia-org-9224 852 8 Sciences Sciences NNPS en-wikipedia-org-9224 852 9 . . . en-wikipedia-org-9224 853 1 992 992 CD en-wikipedia-org-9224 853 2 ( ( -LRB- en-wikipedia-org-9224 853 3 1 1 CD en-wikipedia-org-9224 853 4 ) ) -RRB- en-wikipedia-org-9224 853 5 : : : en-wikipedia-org-9224 853 6 9–20 9–20 CD en-wikipedia-org-9224 853 7 . . . en-wikipedia-org-9224 854 1 Bibcode:2003NYASA.992 Bibcode:2003NYASA.992 NNP en-wikipedia-org-9224 854 2 .... .... NFP en-wikipedia-org-9224 854 3 9K. 9k. CD en-wikipedia-org-9224 855 1 doi:10.1111 doi:10.1111 NNP en-wikipedia-org-9224 855 2 / / SYM en-wikipedia-org-9224 855 3 j.1749 j.1749 NNP en-wikipedia-org-9224 855 4 - - : en-wikipedia-org-9224 855 5 6632.2003.tb03133.x 6632.2003.tb03133.x CD en-wikipedia-org-9224 855 6 . . . en-wikipedia-org-9224 856 1 PMID PMID NNP en-wikipedia-org-9224 856 2   _SP en-wikipedia-org-9224 856 3 12794042 12794042 CD en-wikipedia-org-9224 856 4 . . . en-wikipedia-org-9224 857 1 S2CID S2CID NNS en-wikipedia-org-9224 857 2   _SP en-wikipedia-org-9224 857 3 24508121 24508121 CD en-wikipedia-org-9224 857 4 . . . en-wikipedia-org-9224 858 1 ^ ^ NNP en-wikipedia-org-9224 858 2 Majde Majde NNP en-wikipedia-org-9224 858 3 JA JA NNP en-wikipedia-org-9224 858 4 , , , en-wikipedia-org-9224 858 5 Krueger Krueger NNP en-wikipedia-org-9224 858 6 JM JM NNP en-wikipedia-org-9224 858 7 ( ( -LRB- en-wikipedia-org-9224 858 8 December December NNP en-wikipedia-org-9224 858 9 2005 2005 CD en-wikipedia-org-9224 858 10 ) ) -RRB- en-wikipedia-org-9224 858 11 . . . en-wikipedia-org-9224 859 1 " " `` en-wikipedia-org-9224 859 2 Links link NNS en-wikipedia-org-9224 859 3 between between IN en-wikipedia-org-9224 859 4 the the DT en-wikipedia-org-9224 859 5 innate innate JJ en-wikipedia-org-9224 859 6 immune immune JJ en-wikipedia-org-9224 859 7 system system NN en-wikipedia-org-9224 859 8 and and CC en-wikipedia-org-9224 859 9 sleep sleep NN en-wikipedia-org-9224 859 10 " " '' en-wikipedia-org-9224 859 11 . . . en-wikipedia-org-9224 860 1 The the DT en-wikipedia-org-9224 860 2 Journal Journal NNP en-wikipedia-org-9224 860 3 of of IN en-wikipedia-org-9224 860 4 Allergy Allergy NNP en-wikipedia-org-9224 860 5 and and CC en-wikipedia-org-9224 860 6 Clinical Clinical NNP en-wikipedia-org-9224 860 7 Immunology Immunology NNP en-wikipedia-org-9224 860 8 . . . en-wikipedia-org-9224 861 1 116 116 CD en-wikipedia-org-9224 861 2 ( ( -LRB- en-wikipedia-org-9224 861 3 6 6 CD en-wikipedia-org-9224 861 4 ) ) -RRB- en-wikipedia-org-9224 861 5 : : : en-wikipedia-org-9224 861 6 1188–98 1188–98 LS en-wikipedia-org-9224 861 7 . . . en-wikipedia-org-9224 862 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 862 2 / / SYM en-wikipedia-org-9224 862 3 j.jaci.2005.08.005 j.jaci.2005.08.005 NNP en-wikipedia-org-9224 862 4 . . . en-wikipedia-org-9224 863 1 PMID PMID NNP en-wikipedia-org-9224 863 2   _SP en-wikipedia-org-9224 863 3 16337444 16337444 CD en-wikipedia-org-9224 863 4 . . . en-wikipedia-org-9224 864 1 ^ ^ NFP en-wikipedia-org-9224 864 2 Taylor Taylor NNP en-wikipedia-org-9224 864 3 DJ DJ NNP en-wikipedia-org-9224 864 4 , , , en-wikipedia-org-9224 864 5 Kelly Kelly NNP en-wikipedia-org-9224 864 6 K K NNP en-wikipedia-org-9224 864 7 , , , en-wikipedia-org-9224 864 8 Kohut Kohut NNP en-wikipedia-org-9224 864 9 ML ML NNP en-wikipedia-org-9224 864 10 , , , en-wikipedia-org-9224 864 11 Song Song NNP en-wikipedia-org-9224 864 12 KS KS NNP en-wikipedia-org-9224 864 13 ( ( -LRB- en-wikipedia-org-9224 864 14 2017 2017 CD en-wikipedia-org-9224 864 15 ) ) -RRB- en-wikipedia-org-9224 864 16 . . . en-wikipedia-org-9224 865 1 " " `` en-wikipedia-org-9224 865 2 Is be VBZ en-wikipedia-org-9224 865 3 Insomnia Insomnia NNP en-wikipedia-org-9224 865 4 a a DT en-wikipedia-org-9224 865 5 Risk Risk NNP en-wikipedia-org-9224 865 6 Factor Factor NNP en-wikipedia-org-9224 865 7 for for IN en-wikipedia-org-9224 865 8 Decreased Decreased NNP en-wikipedia-org-9224 865 9 Influenza Influenza NNP en-wikipedia-org-9224 865 10 Vaccine Vaccine NNP en-wikipedia-org-9224 865 11 Response Response NNP en-wikipedia-org-9224 865 12 ? ? . en-wikipedia-org-9224 865 13 " " '' en-wikipedia-org-9224 865 14 . . . en-wikipedia-org-9224 866 1 Behavioral Behavioral NNP en-wikipedia-org-9224 866 2 Sleep Sleep NNP en-wikipedia-org-9224 866 3 Medicine Medicine NNP en-wikipedia-org-9224 866 4 . . . en-wikipedia-org-9224 867 1 15 15 CD en-wikipedia-org-9224 867 2 ( ( -LRB- en-wikipedia-org-9224 867 3 4 4 CD en-wikipedia-org-9224 867 4 ) ) -RRB- en-wikipedia-org-9224 867 5 : : : en-wikipedia-org-9224 867 6 270–287 270–287 CD en-wikipedia-org-9224 867 7 . . . en-wikipedia-org-9224 868 1 doi:10.1080/15402002.2015.1126596 doi:10.1080/15402002.2015.1126596 UH en-wikipedia-org-9224 868 2 . . . en-wikipedia-org-9224 869 1 PMC PMC NNP en-wikipedia-org-9224 869 2   _SP en-wikipedia-org-9224 869 3 5554442 5554442 CD en-wikipedia-org-9224 869 4 . . . en-wikipedia-org-9224 870 1 PMID PMID NNP en-wikipedia-org-9224 870 2   _SP en-wikipedia-org-9224 870 3 27077395 27077395 CD en-wikipedia-org-9224 870 4 . . . en-wikipedia-org-9224 871 1 ^ ^ NNP en-wikipedia-org-9224 871 2 Krueger Krueger NNP en-wikipedia-org-9224 871 3 JM JM NNP en-wikipedia-org-9224 871 4 ( ( -LRB- en-wikipedia-org-9224 871 5 2008 2008 CD en-wikipedia-org-9224 871 6 ) ) -RRB- en-wikipedia-org-9224 871 7 . . . en-wikipedia-org-9224 872 1 " " `` en-wikipedia-org-9224 872 2 The the DT en-wikipedia-org-9224 872 3 role role NN en-wikipedia-org-9224 872 4 of of IN en-wikipedia-org-9224 872 5 cytokines cytokine NNS en-wikipedia-org-9224 872 6 in in IN en-wikipedia-org-9224 872 7 sleep sleep NN en-wikipedia-org-9224 872 8 regulation regulation NN en-wikipedia-org-9224 872 9 " " '' en-wikipedia-org-9224 872 10 . . . en-wikipedia-org-9224 873 1 Current Current NNP en-wikipedia-org-9224 873 2 Pharmaceutical Pharmaceutical NNP en-wikipedia-org-9224 873 3 Design Design NNP en-wikipedia-org-9224 873 4 . . . en-wikipedia-org-9224 874 1 14 14 CD en-wikipedia-org-9224 874 2 ( ( -LRB- en-wikipedia-org-9224 874 3 32 32 CD en-wikipedia-org-9224 874 4 ) ) -RRB- en-wikipedia-org-9224 874 5 : : : en-wikipedia-org-9224 874 6 3408–16 3408–16 LS en-wikipedia-org-9224 874 7 . . . en-wikipedia-org-9224 875 1 doi:10.2174/138161208786549281 doi:10.2174/138161208786549281 VBG en-wikipedia-org-9224 875 2 . . . en-wikipedia-org-9224 876 1 PMC PMC NNP en-wikipedia-org-9224 876 2   _SP en-wikipedia-org-9224 876 3 2692603 2692603 CD en-wikipedia-org-9224 876 4 . . . en-wikipedia-org-9224 877 1 PMID PMID NNP en-wikipedia-org-9224 877 2   _SP en-wikipedia-org-9224 877 3 19075717 19075717 CD en-wikipedia-org-9224 877 4 . . . en-wikipedia-org-9224 878 1 ^ ^ NNP en-wikipedia-org-9224 878 2 a a DT en-wikipedia-org-9224 878 3 b b NN en-wikipedia-org-9224 878 4 Besedovsky Besedovsky NNP en-wikipedia-org-9224 878 5 L L NNP en-wikipedia-org-9224 878 6 , , , en-wikipedia-org-9224 878 7 Lange Lange NNP en-wikipedia-org-9224 878 8 T T NNP en-wikipedia-org-9224 878 9 , , , en-wikipedia-org-9224 878 10 Born Born NNP en-wikipedia-org-9224 878 11 J J NNP en-wikipedia-org-9224 878 12 ( ( -LRB- en-wikipedia-org-9224 878 13 January January NNP en-wikipedia-org-9224 878 14 2012 2012 CD en-wikipedia-org-9224 878 15 ) ) -RRB- en-wikipedia-org-9224 878 16 . . . en-wikipedia-org-9224 879 1 " " `` en-wikipedia-org-9224 879 2 Sleep sleep NN en-wikipedia-org-9224 879 3 and and CC en-wikipedia-org-9224 879 4 immune immune JJ en-wikipedia-org-9224 879 5 function function NN en-wikipedia-org-9224 879 6 " " '' en-wikipedia-org-9224 879 7 . . . en-wikipedia-org-9224 880 1 Pflügers Pflügers NNP en-wikipedia-org-9224 880 2 Archiv Archiv NNP en-wikipedia-org-9224 880 3 . . . en-wikipedia-org-9224 881 1 463 463 CD en-wikipedia-org-9224 881 2 ( ( -LRB- en-wikipedia-org-9224 881 3 1 1 CD en-wikipedia-org-9224 881 4 ) ) -RRB- en-wikipedia-org-9224 881 5 : : : en-wikipedia-org-9224 881 6 121–37 121–37 CD en-wikipedia-org-9224 881 7 . . . en-wikipedia-org-9224 882 1 doi:10.1007 doi:10.1007 NNP en-wikipedia-org-9224 882 2 / / SYM en-wikipedia-org-9224 882 3 s00424 s00424 CD en-wikipedia-org-9224 882 4 - - HYPH en-wikipedia-org-9224 882 5 011 011 CD en-wikipedia-org-9224 882 6 - - HYPH en-wikipedia-org-9224 882 7 1044 1044 CD en-wikipedia-org-9224 882 8 - - HYPH en-wikipedia-org-9224 882 9 0 0 CD en-wikipedia-org-9224 882 10 . . . en-wikipedia-org-9224 883 1 PMC PMC NNP en-wikipedia-org-9224 883 2   _SP en-wikipedia-org-9224 883 3 3256323 3256323 CD en-wikipedia-org-9224 883 4 . . . en-wikipedia-org-9224 884 1 PMID PMID NNP en-wikipedia-org-9224 884 2   _SP en-wikipedia-org-9224 884 3 22071480 22071480 CD en-wikipedia-org-9224 884 4 . . . en-wikipedia-org-9224 885 1 ^ ^ FW en-wikipedia-org-9224 885 2 " " `` en-wikipedia-org-9224 885 3 Can Can MD en-wikipedia-org-9224 885 4 Better well JJR en-wikipedia-org-9224 885 5 Sleep sleep VB en-wikipedia-org-9224 885 6 Mean mean NN en-wikipedia-org-9224 885 7 Catching catch VBG en-wikipedia-org-9224 885 8 fewer few JJR en-wikipedia-org-9224 885 9 Colds Colds NNP en-wikipedia-org-9224 885 10 ? ? . en-wikipedia-org-9224 885 11 " " '' en-wikipedia-org-9224 885 12 . . . en-wikipedia-org-9224 886 1 Archived archived JJ en-wikipedia-org-9224 886 2 from from IN en-wikipedia-org-9224 886 3 the the DT en-wikipedia-org-9224 886 4 original original NN en-wikipedia-org-9224 886 5 on on IN en-wikipedia-org-9224 886 6 9 9 CD en-wikipedia-org-9224 886 7 May May NNP en-wikipedia-org-9224 886 8 2014 2014 CD en-wikipedia-org-9224 886 9 . . . en-wikipedia-org-9224 887 1 Retrieved retrieve VBN en-wikipedia-org-9224 887 2 28 28 CD en-wikipedia-org-9224 887 3 April April NNP en-wikipedia-org-9224 887 4 2014 2014 CD en-wikipedia-org-9224 887 5 . . . en-wikipedia-org-9224 888 1 ^ ^ NNP en-wikipedia-org-9224 888 2 Suskind Suskind NNP en-wikipedia-org-9224 888 3 RM RM NNP en-wikipedia-org-9224 888 4 , , , en-wikipedia-org-9224 888 5 Lachney Lachney NNP en-wikipedia-org-9224 888 6 CL CL NNP en-wikipedia-org-9224 888 7 , , , en-wikipedia-org-9224 888 8 Udall Udall NNP en-wikipedia-org-9224 888 9 JN JN NNP en-wikipedia-org-9224 888 10 ( ( -LRB- en-wikipedia-org-9224 888 11 1994 1994 CD en-wikipedia-org-9224 888 12 ) ) -RRB- en-wikipedia-org-9224 888 13 . . . en-wikipedia-org-9224 889 1 " " `` en-wikipedia-org-9224 889 2 Malnutrition Malnutrition NNP en-wikipedia-org-9224 889 3 and and CC en-wikipedia-org-9224 889 4 the the DT en-wikipedia-org-9224 889 5 Immune Immune NNP en-wikipedia-org-9224 889 6 Response Response NNP en-wikipedia-org-9224 889 7 " " '' en-wikipedia-org-9224 889 8 , , , en-wikipedia-org-9224 889 9 in in IN en-wikipedia-org-9224 889 10 Serrano Serrano NNP en-wikipedia-org-9224 889 11 - - HYPH en-wikipedia-org-9224 889 12 Ríos Ríos NNP en-wikipedia-org-9224 889 13 M M NNP en-wikipedia-org-9224 889 14 , , , en-wikipedia-org-9224 889 15 ed ed NNP en-wikipedia-org-9224 889 16 . . NNP en-wikipedia-org-9224 889 17 , , , en-wikipedia-org-9224 889 18 Dairy Dairy NNP en-wikipedia-org-9224 889 19 products product NNS en-wikipedia-org-9224 889 20 in in IN en-wikipedia-org-9224 889 21 human human JJ en-wikipedia-org-9224 889 22 health health NN en-wikipedia-org-9224 889 23 and and CC en-wikipedia-org-9224 889 24 nutrition nutrition NN en-wikipedia-org-9224 889 25 , , , en-wikipedia-org-9224 889 26 CRC CRC NNP en-wikipedia-org-9224 889 27 Press Press NNP en-wikipedia-org-9224 889 28 , , , en-wikipedia-org-9224 889 29 pp pp NNP en-wikipedia-org-9224 889 30 . . . en-wikipedia-org-9224 890 1 285–300 285–300 CD en-wikipedia-org-9224 890 2 ^ ^ . en-wikipedia-org-9224 890 3 Pond Pond NNP en-wikipedia-org-9224 890 4 CM CM NNP en-wikipedia-org-9224 890 5 ( ( -LRB- en-wikipedia-org-9224 890 6 July July NNP en-wikipedia-org-9224 890 7 2005 2005 CD en-wikipedia-org-9224 890 8 ) ) -RRB- en-wikipedia-org-9224 890 9 . . . en-wikipedia-org-9224 891 1 " " `` en-wikipedia-org-9224 891 2 Adipose adipose JJ en-wikipedia-org-9224 891 3 tissue tissue NN en-wikipedia-org-9224 891 4 and and CC en-wikipedia-org-9224 891 5 the the DT en-wikipedia-org-9224 891 6 immune immune JJ en-wikipedia-org-9224 891 7 system system NN en-wikipedia-org-9224 891 8 " " '' en-wikipedia-org-9224 891 9 . . . en-wikipedia-org-9224 892 1 Prostaglandins Prostaglandins NNP en-wikipedia-org-9224 892 2 , , , en-wikipedia-org-9224 892 3 Leukotrienes Leukotrienes NNP en-wikipedia-org-9224 892 4 , , , en-wikipedia-org-9224 892 5 and and CC en-wikipedia-org-9224 892 6 Essential Essential NNP en-wikipedia-org-9224 892 7 Fatty Fatty NNP en-wikipedia-org-9224 892 8 Acids Acids NNPS en-wikipedia-org-9224 892 9 . . . en-wikipedia-org-9224 893 1 73 73 CD en-wikipedia-org-9224 893 2 ( ( -LRB- en-wikipedia-org-9224 893 3 1 1 CD en-wikipedia-org-9224 893 4 ) ) -RRB- en-wikipedia-org-9224 893 5 : : : en-wikipedia-org-9224 893 6 17–30 17–30 CD en-wikipedia-org-9224 893 7 . . . en-wikipedia-org-9224 894 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 894 2 / / SYM en-wikipedia-org-9224 894 3 j.plefa.2005.04.005 j.plefa.2005.04.005 NN en-wikipedia-org-9224 894 4 . . . en-wikipedia-org-9224 895 1 PMID PMID NNP en-wikipedia-org-9224 895 2   _SP en-wikipedia-org-9224 895 3 15946832 15946832 CD en-wikipedia-org-9224 895 4 . . . en-wikipedia-org-9224 896 1 ^ ^ NNP en-wikipedia-org-9224 896 2 Langley Langley NNP en-wikipedia-org-9224 896 3 - - HYPH en-wikipedia-org-9224 896 4 Evans Evans NNP en-wikipedia-org-9224 896 5 SC SC NNP en-wikipedia-org-9224 896 6 , , , en-wikipedia-org-9224 896 7 Carrington Carrington NNP en-wikipedia-org-9224 896 8 LJ LJ NNP en-wikipedia-org-9224 896 9 ( ( -LRB- en-wikipedia-org-9224 896 10 2006 2006 CD en-wikipedia-org-9224 896 11 ) ) -RRB- en-wikipedia-org-9224 896 12 . . . en-wikipedia-org-9224 897 1 " " `` en-wikipedia-org-9224 897 2 Diet Diet NNP en-wikipedia-org-9224 897 3 and and CC en-wikipedia-org-9224 897 4 the the DT en-wikipedia-org-9224 897 5 developing develop VBG en-wikipedia-org-9224 897 6 immune immune JJ en-wikipedia-org-9224 897 7 system system NN en-wikipedia-org-9224 897 8 " " '' en-wikipedia-org-9224 897 9 . . . en-wikipedia-org-9224 898 1 Lupus Lupus NNP en-wikipedia-org-9224 898 2 . . . en-wikipedia-org-9224 899 1 15 15 CD en-wikipedia-org-9224 899 2 ( ( -LRB- en-wikipedia-org-9224 899 3 11 11 CD en-wikipedia-org-9224 899 4 ) ) -RRB- en-wikipedia-org-9224 899 5 : : : en-wikipedia-org-9224 899 6 746–52 746–52 CD en-wikipedia-org-9224 899 7 . . . en-wikipedia-org-9224 900 1 doi:10.1177/0961203306070001 doi:10.1177/0961203306070001 NNP en-wikipedia-org-9224 900 2 . . . en-wikipedia-org-9224 901 1 PMID PMID NNP en-wikipedia-org-9224 901 2   _SP en-wikipedia-org-9224 901 3 17153845 17153845 CD en-wikipedia-org-9224 901 4 . . . en-wikipedia-org-9224 902 1 S2CID S2CID NNS en-wikipedia-org-9224 902 2   _SP en-wikipedia-org-9224 902 3 30576003 30576003 CD en-wikipedia-org-9224 902 4 . . . en-wikipedia-org-9224 903 1 ^ ^ NFP en-wikipedia-org-9224 903 2 Godwin Godwin NNP en-wikipedia-org-9224 903 3 JW JW NNP en-wikipedia-org-9224 903 4 , , , en-wikipedia-org-9224 903 5 Pinto Pinto NNP en-wikipedia-org-9224 903 6 AR AR NNP en-wikipedia-org-9224 903 7 , , , en-wikipedia-org-9224 903 8 Rosenthal Rosenthal NNP en-wikipedia-org-9224 903 9 NA NA NNP en-wikipedia-org-9224 903 10 ( ( -LRB- en-wikipedia-org-9224 903 11 January January NNP en-wikipedia-org-9224 903 12 2017 2017 CD en-wikipedia-org-9224 903 13 ) ) -RRB- en-wikipedia-org-9224 903 14 . . . en-wikipedia-org-9224 904 1 " " `` en-wikipedia-org-9224 904 2 Chasing chase VBG en-wikipedia-org-9224 904 3 the the DT en-wikipedia-org-9224 904 4 recipe recipe NN en-wikipedia-org-9224 904 5 for for IN en-wikipedia-org-9224 904 6 a a DT en-wikipedia-org-9224 904 7 pro pro JJ en-wikipedia-org-9224 904 8 - - JJ en-wikipedia-org-9224 904 9 regenerative regenerative JJ en-wikipedia-org-9224 904 10 immune immune JJ en-wikipedia-org-9224 904 11 system system NN en-wikipedia-org-9224 904 12 " " '' en-wikipedia-org-9224 904 13 . . . en-wikipedia-org-9224 905 1 Seminars seminar NNS en-wikipedia-org-9224 905 2 in in IN en-wikipedia-org-9224 905 3 Cell Cell NNP en-wikipedia-org-9224 905 4 & & CC en-wikipedia-org-9224 905 5 Developmental Developmental NNP en-wikipedia-org-9224 905 6 Biology Biology NNP en-wikipedia-org-9224 905 7 . . . en-wikipedia-org-9224 906 1 Innate innate VB en-wikipedia-org-9224 906 2 immune immune JJ en-wikipedia-org-9224 906 3 pathways pathway NNS en-wikipedia-org-9224 906 4 in in IN en-wikipedia-org-9224 906 5 wound wind VBN en-wikipedia-org-9224 906 6 healing healing NN en-wikipedia-org-9224 906 7 / / SYM en-wikipedia-org-9224 906 8 Peromyscus Peromyscus NNP en-wikipedia-org-9224 906 9 as as IN en-wikipedia-org-9224 906 10 a a DT en-wikipedia-org-9224 906 11 model model NN en-wikipedia-org-9224 906 12 system system NN en-wikipedia-org-9224 906 13 . . . en-wikipedia-org-9224 907 1 61 61 CD en-wikipedia-org-9224 907 2 : : : en-wikipedia-org-9224 907 3 71–79 71–79 CD en-wikipedia-org-9224 907 4 . . . en-wikipedia-org-9224 908 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 908 2 / / SYM en-wikipedia-org-9224 908 3 j.semcdb.2016.08.008 j.semcdb.2016.08.008 JJ en-wikipedia-org-9224 908 4 . . . en-wikipedia-org-9224 909 1 PMC PMC NNP en-wikipedia-org-9224 909 2   _SP en-wikipedia-org-9224 909 3 5338634 5338634 CD en-wikipedia-org-9224 909 4 . . . en-wikipedia-org-9224 910 1 PMID PMID NNP en-wikipedia-org-9224 910 2   _SP en-wikipedia-org-9224 910 3 27521522 27521522 CD en-wikipedia-org-9224 910 4 . . . en-wikipedia-org-9224 911 1 ^ ^ NNP en-wikipedia-org-9224 911 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 911 3 2019 2019 CD en-wikipedia-org-9224 911 4 , , , en-wikipedia-org-9224 911 5 pp pp NNP en-wikipedia-org-9224 911 6 . . . en-wikipedia-org-9224 912 1 120–24 120–24 LS en-wikipedia-org-9224 912 2 . . . en-wikipedia-org-9224 913 1 ^ ^ NNP en-wikipedia-org-9224 913 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 913 3 2019 2019 CD en-wikipedia-org-9224 913 4 , , , en-wikipedia-org-9224 913 5 pp pp NNP en-wikipedia-org-9224 913 6 . . . en-wikipedia-org-9224 914 1 114–18 114–18 CD en-wikipedia-org-9224 914 2 . . . en-wikipedia-org-9224 915 1 ^ ^ NNP en-wikipedia-org-9224 915 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 915 3 2019 2019 CD en-wikipedia-org-9224 915 4 , , , en-wikipedia-org-9224 915 5 pp pp NNP en-wikipedia-org-9224 915 6 . . . en-wikipedia-org-9224 916 1 111–14 111–14 CD en-wikipedia-org-9224 916 2 . . . en-wikipedia-org-9224 917 1 ^ ^ NNP en-wikipedia-org-9224 917 2 Aw Aw NNP en-wikipedia-org-9224 917 3 D d NN en-wikipedia-org-9224 917 4 , , , en-wikipedia-org-9224 917 5 Silva Silva NNP en-wikipedia-org-9224 917 6 AB AB NNP en-wikipedia-org-9224 917 7 , , , en-wikipedia-org-9224 917 8 Palmer Palmer NNP en-wikipedia-org-9224 917 9 DB DB NNP en-wikipedia-org-9224 917 10 ( ( -LRB- en-wikipedia-org-9224 917 11 April April NNP en-wikipedia-org-9224 917 12 2007 2007 CD en-wikipedia-org-9224 917 13 ) ) -RRB- en-wikipedia-org-9224 917 14 . . . en-wikipedia-org-9224 918 1 " " `` en-wikipedia-org-9224 918 2 Immunosenescence immunosenescence NN en-wikipedia-org-9224 918 3 : : : en-wikipedia-org-9224 918 4 emerging emerge VBG en-wikipedia-org-9224 918 5 challenges challenge NNS en-wikipedia-org-9224 918 6 for for IN en-wikipedia-org-9224 918 7 an an DT en-wikipedia-org-9224 918 8 ageing age VBG en-wikipedia-org-9224 918 9 population population NN en-wikipedia-org-9224 918 10 " " '' en-wikipedia-org-9224 918 11 . . . en-wikipedia-org-9224 919 1 Immunology immunology NN en-wikipedia-org-9224 919 2 . . . en-wikipedia-org-9224 920 1 120 120 CD en-wikipedia-org-9224 920 2 ( ( -LRB- en-wikipedia-org-9224 920 3 4 4 CD en-wikipedia-org-9224 920 4 ) ) -RRB- en-wikipedia-org-9224 920 5 : : : en-wikipedia-org-9224 920 6 435–46 435–46 CD en-wikipedia-org-9224 920 7 . . . en-wikipedia-org-9224 921 1 doi:10.1111 doi:10.1111 NNP en-wikipedia-org-9224 921 2 / / SYM en-wikipedia-org-9224 921 3 j.1365 j.1365 NNP en-wikipedia-org-9224 921 4 - - HYPH en-wikipedia-org-9224 921 5 2567.2007.02555.x 2567.2007.02555.x NNP en-wikipedia-org-9224 921 6 . . . en-wikipedia-org-9224 922 1 PMC PMC NNP en-wikipedia-org-9224 922 2   _SP en-wikipedia-org-9224 922 3 2265901 2265901 CD en-wikipedia-org-9224 922 4 . . . en-wikipedia-org-9224 923 1 PMID PMID NNP en-wikipedia-org-9224 923 2   _SP en-wikipedia-org-9224 923 3 17313487 17313487 CD en-wikipedia-org-9224 923 4 . . . en-wikipedia-org-9224 924 1 ^ ^ NNP en-wikipedia-org-9224 924 2 a a DT en-wikipedia-org-9224 924 3 b b NNP en-wikipedia-org-9224 924 4 Chandra Chandra NNP en-wikipedia-org-9224 924 5 RK RK NNP en-wikipedia-org-9224 924 6 ( ( -LRB- en-wikipedia-org-9224 924 7 August August NNP en-wikipedia-org-9224 924 8 1997 1997 CD en-wikipedia-org-9224 924 9 ) ) -RRB- en-wikipedia-org-9224 924 10 . . . en-wikipedia-org-9224 925 1 " " `` en-wikipedia-org-9224 925 2 Nutrition nutrition NN en-wikipedia-org-9224 925 3 and and CC en-wikipedia-org-9224 925 4 the the DT en-wikipedia-org-9224 925 5 immune immune JJ en-wikipedia-org-9224 925 6 system system NN en-wikipedia-org-9224 925 7 : : : en-wikipedia-org-9224 925 8 an an DT en-wikipedia-org-9224 925 9 introduction introduction NN en-wikipedia-org-9224 925 10 " " '' en-wikipedia-org-9224 925 11 . . . en-wikipedia-org-9224 926 1 The the DT en-wikipedia-org-9224 926 2 American American NNP en-wikipedia-org-9224 926 3 Journal Journal NNP en-wikipedia-org-9224 926 4 of of IN en-wikipedia-org-9224 926 5 Clinical Clinical NNP en-wikipedia-org-9224 926 6 Nutrition Nutrition NNP en-wikipedia-org-9224 926 7 . . . en-wikipedia-org-9224 927 1 66 66 CD en-wikipedia-org-9224 927 2 ( ( -LRB- en-wikipedia-org-9224 927 3 2 2 CD en-wikipedia-org-9224 927 4 ) ) -RRB- en-wikipedia-org-9224 927 5 : : : en-wikipedia-org-9224 927 6 460S–63S. 460s–63s. CD en-wikipedia-org-9224 928 1 doi:10.1093 doi:10.1093 NNP en-wikipedia-org-9224 928 2 / / SYM en-wikipedia-org-9224 928 3 ajcn/66.2.460S. ajcn/66.2.460S. NNP en-wikipedia-org-9224 929 1 PMID PMID NNP en-wikipedia-org-9224 929 2   _SP en-wikipedia-org-9224 929 3 9250133 9250133 CD en-wikipedia-org-9224 929 4 . . . en-wikipedia-org-9224 930 1 ^ ^ NNP en-wikipedia-org-9224 930 2 Miller Miller NNP en-wikipedia-org-9224 930 3 JF JF NNP en-wikipedia-org-9224 930 4 ( ( -LRB- en-wikipedia-org-9224 930 5 July July NNP en-wikipedia-org-9224 930 6 2002 2002 CD en-wikipedia-org-9224 930 7 ) ) -RRB- en-wikipedia-org-9224 930 8 . . . en-wikipedia-org-9224 931 1 " " `` en-wikipedia-org-9224 931 2 The the DT en-wikipedia-org-9224 931 3 discovery discovery NN en-wikipedia-org-9224 931 4 of of IN en-wikipedia-org-9224 931 5 thymus thymus NN en-wikipedia-org-9224 931 6 function function NN en-wikipedia-org-9224 931 7 and and CC en-wikipedia-org-9224 931 8 of of IN en-wikipedia-org-9224 931 9 thymus thymus NN en-wikipedia-org-9224 931 10 - - HYPH en-wikipedia-org-9224 931 11 derived derive VBN en-wikipedia-org-9224 931 12 lymphocytes lymphocyte NNS en-wikipedia-org-9224 931 13 " " '' en-wikipedia-org-9224 931 14 . . . en-wikipedia-org-9224 932 1 Immunological Immunological NNP en-wikipedia-org-9224 932 2 Reviews Reviews NNPS en-wikipedia-org-9224 932 3 . . . en-wikipedia-org-9224 933 1 185 185 CD en-wikipedia-org-9224 933 2 ( ( -LRB- en-wikipedia-org-9224 933 3 1 1 CD en-wikipedia-org-9224 933 4 ) ) -RRB- en-wikipedia-org-9224 933 5 : : : en-wikipedia-org-9224 933 6 7–14 7–14 CD en-wikipedia-org-9224 933 7 . . . en-wikipedia-org-9224 934 1 doi:10.1034 doi:10.1034 NNP en-wikipedia-org-9224 934 2 / / SYM en-wikipedia-org-9224 934 3 j.1600 j.1600 NNP en-wikipedia-org-9224 934 4 - - HYPH en-wikipedia-org-9224 934 5 065X.2002.18502.x 065X.2002.18502.x NNP en-wikipedia-org-9224 934 6 . . . en-wikipedia-org-9224 935 1 PMID PMID NNP en-wikipedia-org-9224 935 2   _SP en-wikipedia-org-9224 935 3 12190917 12190917 CD en-wikipedia-org-9224 935 4 . . . en-wikipedia-org-9224 936 1 S2CID S2CID NNS en-wikipedia-org-9224 936 2   _SP en-wikipedia-org-9224 936 3 12108587 12108587 CD en-wikipedia-org-9224 936 4 . . . en-wikipedia-org-9224 937 1 ^ ^ NNP en-wikipedia-org-9224 937 2 Reece Reece NNP en-wikipedia-org-9224 937 3 2011 2011 CD en-wikipedia-org-9224 937 4 , , , en-wikipedia-org-9224 937 5 p. p. NN en-wikipedia-org-9224 937 6   _SP en-wikipedia-org-9224 937 7 967 967 CD en-wikipedia-org-9224 937 8 . . . en-wikipedia-org-9224 938 1 ^ ^ NNP en-wikipedia-org-9224 938 2 Burg Burg NNP en-wikipedia-org-9224 938 3 M M NNP en-wikipedia-org-9224 938 4 , , , en-wikipedia-org-9224 938 5 Gennery Gennery NNP en-wikipedia-org-9224 938 6 AR AR NNP en-wikipedia-org-9224 938 7 ( ( -LRB- en-wikipedia-org-9224 938 8 2011 2011 CD en-wikipedia-org-9224 938 9 ) ) -RRB- en-wikipedia-org-9224 938 10 . . . en-wikipedia-org-9224 939 1 " " `` en-wikipedia-org-9224 939 2 Educational educational JJ en-wikipedia-org-9224 939 3 paper paper NN en-wikipedia-org-9224 939 4 : : : en-wikipedia-org-9224 939 5 The the DT en-wikipedia-org-9224 939 6 expanding expand VBG en-wikipedia-org-9224 939 7 clinical clinical JJ en-wikipedia-org-9224 939 8 and and CC en-wikipedia-org-9224 939 9 immunological immunological JJ en-wikipedia-org-9224 939 10 spectrum spectrum NN en-wikipedia-org-9224 939 11 of of IN en-wikipedia-org-9224 939 12 severe severe JJ en-wikipedia-org-9224 939 13 combined combined JJ en-wikipedia-org-9224 939 14 immunodeficiency immunodeficiency NN en-wikipedia-org-9224 939 15 " " '' en-wikipedia-org-9224 939 16 . . . en-wikipedia-org-9224 940 1 Eur Eur NNP en-wikipedia-org-9224 940 2 J J NNP en-wikipedia-org-9224 940 3 Pediatr Pediatr NNP en-wikipedia-org-9224 940 4 . . . en-wikipedia-org-9224 941 1 170 170 CD en-wikipedia-org-9224 941 2 ( ( -LRB- en-wikipedia-org-9224 941 3 5 5 CD en-wikipedia-org-9224 941 4 ) ) -RRB- en-wikipedia-org-9224 941 5 : : : en-wikipedia-org-9224 941 6 561–571 561–571 CD en-wikipedia-org-9224 941 7 . . . en-wikipedia-org-9224 942 1 doi:10.1007 doi:10.1007 NNP en-wikipedia-org-9224 942 2 / / SYM en-wikipedia-org-9224 942 3 s00431 s00431 NNP en-wikipedia-org-9224 942 4 - - HYPH en-wikipedia-org-9224 942 5 011 011 CD en-wikipedia-org-9224 942 6 - - HYPH en-wikipedia-org-9224 942 7 1452 1452 CD en-wikipedia-org-9224 942 8 - - SYM en-wikipedia-org-9224 942 9 3 3 CD en-wikipedia-org-9224 942 10 . . . en-wikipedia-org-9224 943 1 PMC PMC NNP en-wikipedia-org-9224 943 2   _SP en-wikipedia-org-9224 943 3 3078321 3078321 CD en-wikipedia-org-9224 943 4 . . . en-wikipedia-org-9224 944 1 PMID PMID NNP en-wikipedia-org-9224 944 2   _SP en-wikipedia-org-9224 944 3 21479529 21479529 CD en-wikipedia-org-9224 944 4 . . . en-wikipedia-org-9224 945 1 ^ ^ NNP en-wikipedia-org-9224 945 2 Joos Joos NNP en-wikipedia-org-9224 945 3 L L NNP en-wikipedia-org-9224 945 4 , , , en-wikipedia-org-9224 945 5 Tamm Tamm NNP en-wikipedia-org-9224 945 6 M M NNP en-wikipedia-org-9224 945 7 ( ( -LRB- en-wikipedia-org-9224 945 8 2005 2005 CD en-wikipedia-org-9224 945 9 ) ) -RRB- en-wikipedia-org-9224 945 10 . . . en-wikipedia-org-9224 946 1 " " `` en-wikipedia-org-9224 946 2 Breakdown Breakdown NNP en-wikipedia-org-9224 946 3 of of IN en-wikipedia-org-9224 946 4 pulmonary pulmonary JJ en-wikipedia-org-9224 946 5 host host NN en-wikipedia-org-9224 946 6 defense defense NN en-wikipedia-org-9224 946 7 in in IN en-wikipedia-org-9224 946 8 the the DT en-wikipedia-org-9224 946 9 immunocompromised immunocompromise VBN en-wikipedia-org-9224 946 10 host host NN en-wikipedia-org-9224 946 11 : : : en-wikipedia-org-9224 946 12 cancer cancer NN en-wikipedia-org-9224 946 13 chemotherapy chemotherapy NN en-wikipedia-org-9224 946 14 " " '' en-wikipedia-org-9224 946 15 . . . en-wikipedia-org-9224 947 1 Proceedings proceeding NNS en-wikipedia-org-9224 947 2 of of IN en-wikipedia-org-9224 947 3 the the DT en-wikipedia-org-9224 947 4 American American NNP en-wikipedia-org-9224 947 5 Thoracic Thoracic NNP en-wikipedia-org-9224 947 6 Society Society NNP en-wikipedia-org-9224 947 7 . . . en-wikipedia-org-9224 948 1 2 2 CD en-wikipedia-org-9224 948 2 ( ( -LRB- en-wikipedia-org-9224 948 3 5 5 CD en-wikipedia-org-9224 948 4 ) ) -RRB- en-wikipedia-org-9224 948 5 : : : en-wikipedia-org-9224 948 6 445–48 445–48 CD en-wikipedia-org-9224 948 7 . . . en-wikipedia-org-9224 949 1 doi:10.1513 doi:10.1513 NNP en-wikipedia-org-9224 949 2 / / SYM en-wikipedia-org-9224 949 3 pats.200508 pats.200508 NNP en-wikipedia-org-9224 949 4 - - HYPH en-wikipedia-org-9224 949 5 097JS 097JS NNP en-wikipedia-org-9224 949 6 . . . en-wikipedia-org-9224 950 1 PMID PMID NNP en-wikipedia-org-9224 950 2   _SP en-wikipedia-org-9224 950 3 16322598 16322598 CD en-wikipedia-org-9224 950 4 . . . en-wikipedia-org-9224 951 1 ^ ^ NNP en-wikipedia-org-9224 951 2 Copeland Copeland NNP en-wikipedia-org-9224 951 3 KF KF NNP en-wikipedia-org-9224 951 4 , , , en-wikipedia-org-9224 951 5 Heeney Heeney NNP en-wikipedia-org-9224 951 6 JL JL NNP en-wikipedia-org-9224 951 7 ( ( -LRB- en-wikipedia-org-9224 951 8 December December NNP en-wikipedia-org-9224 951 9 1996 1996 CD en-wikipedia-org-9224 951 10 ) ) -RRB- en-wikipedia-org-9224 951 11 . . . en-wikipedia-org-9224 952 1 " " `` en-wikipedia-org-9224 952 2 T t NN en-wikipedia-org-9224 952 3 helper helper NN en-wikipedia-org-9224 952 4 cell cell NN en-wikipedia-org-9224 952 5 activation activation NN en-wikipedia-org-9224 952 6 and and CC en-wikipedia-org-9224 952 7 human human JJ en-wikipedia-org-9224 952 8 retroviral retroviral JJ en-wikipedia-org-9224 952 9 pathogenesis pathogenesis NN en-wikipedia-org-9224 952 10 " " '' en-wikipedia-org-9224 952 11 . . . en-wikipedia-org-9224 953 1 Microbiological Microbiological NNP en-wikipedia-org-9224 953 2 Reviews Reviews NNPS en-wikipedia-org-9224 953 3 . . . en-wikipedia-org-9224 954 1 60 60 CD en-wikipedia-org-9224 954 2 ( ( -LRB- en-wikipedia-org-9224 954 3 4 4 CD en-wikipedia-org-9224 954 4 ) ) -RRB- en-wikipedia-org-9224 954 5 : : : en-wikipedia-org-9224 954 6 722–42 722–42 CD en-wikipedia-org-9224 954 7 . . . en-wikipedia-org-9224 955 1 doi:10.1128 doi:10.1128 NNP en-wikipedia-org-9224 955 2 / / SYM en-wikipedia-org-9224 955 3 MMBR.60.4.722 MMBR.60.4.722 NNP en-wikipedia-org-9224 955 4 - - HYPH en-wikipedia-org-9224 955 5 742.1996 742.1996 CD en-wikipedia-org-9224 955 6 . . . en-wikipedia-org-9224 956 1 PMC PMC NNP en-wikipedia-org-9224 956 2   _SP en-wikipedia-org-9224 956 3 239461 239461 CD en-wikipedia-org-9224 956 4 . . . en-wikipedia-org-9224 957 1 PMID PMID NNP en-wikipedia-org-9224 957 2   _SP en-wikipedia-org-9224 957 3 8987361 8987361 CD en-wikipedia-org-9224 957 4 . . . en-wikipedia-org-9224 958 1 ^ ^ NNP en-wikipedia-org-9224 958 2 Miller Miller NNP en-wikipedia-org-9224 958 3 JF JF NNP en-wikipedia-org-9224 958 4 ( ( -LRB- en-wikipedia-org-9224 958 5 1993 1993 CD en-wikipedia-org-9224 958 6 ) ) -RRB- en-wikipedia-org-9224 958 7 . . . en-wikipedia-org-9224 959 1 " " `` en-wikipedia-org-9224 959 2 Self self NN en-wikipedia-org-9224 959 3 - - HYPH en-wikipedia-org-9224 959 4 nonself nonself NN en-wikipedia-org-9224 959 5 discrimination discrimination NN en-wikipedia-org-9224 959 6 and and CC en-wikipedia-org-9224 959 7 tolerance tolerance NN en-wikipedia-org-9224 959 8 in in IN en-wikipedia-org-9224 959 9 T t NN en-wikipedia-org-9224 959 10 and and CC en-wikipedia-org-9224 959 11 B b NN en-wikipedia-org-9224 959 12 lymphocytes lymphocyte NNS en-wikipedia-org-9224 959 13 " " '' en-wikipedia-org-9224 959 14 . . . en-wikipedia-org-9224 960 1 Immunologic Immunologic NNP en-wikipedia-org-9224 960 2 Research Research NNP en-wikipedia-org-9224 960 3 . . . en-wikipedia-org-9224 961 1 12 12 CD en-wikipedia-org-9224 961 2 ( ( -LRB- en-wikipedia-org-9224 961 3 2 2 CD en-wikipedia-org-9224 961 4 ) ) -RRB- en-wikipedia-org-9224 961 5 : : : en-wikipedia-org-9224 961 6 115–30 115–30 CD en-wikipedia-org-9224 961 7 . . . en-wikipedia-org-9224 962 1 doi:10.1007 doi:10.1007 NNP en-wikipedia-org-9224 962 2 / / SYM en-wikipedia-org-9224 962 3 BF02918299 BF02918299 NNP en-wikipedia-org-9224 962 4 . . . en-wikipedia-org-9224 963 1 PMID PMID NNP en-wikipedia-org-9224 963 2   _SP en-wikipedia-org-9224 963 3 8254222 8254222 CD en-wikipedia-org-9224 963 4 . . . en-wikipedia-org-9224 964 1 S2CID S2CID NNS en-wikipedia-org-9224 964 2   _SP en-wikipedia-org-9224 964 3 32476323 32476323 CD en-wikipedia-org-9224 964 4 . . . en-wikipedia-org-9224 965 1 ^ ^ FW en-wikipedia-org-9224 965 2 " " `` en-wikipedia-org-9224 965 3 Hashimoto Hashimoto NNP en-wikipedia-org-9224 965 4 's 's POS en-wikipedia-org-9224 965 5 disease disease NN en-wikipedia-org-9224 965 6 " " '' en-wikipedia-org-9224 965 7 . . . en-wikipedia-org-9224 966 1 Office office NN en-wikipedia-org-9224 966 2 on on IN en-wikipedia-org-9224 966 3 Women Women NNP en-wikipedia-org-9224 966 4 ’s ’s NNP en-wikipedia-org-9224 966 5 Health Health NNP en-wikipedia-org-9224 966 6 , , , en-wikipedia-org-9224 966 7 U.S. U.S. NNP en-wikipedia-org-9224 966 8 Department Department NNP en-wikipedia-org-9224 966 9 of of IN en-wikipedia-org-9224 966 10 Health Health NNP en-wikipedia-org-9224 966 11 and and CC en-wikipedia-org-9224 966 12 Human Human NNP en-wikipedia-org-9224 966 13 Services Services NNPS en-wikipedia-org-9224 966 14 . . . en-wikipedia-org-9224 967 1 12 12 CD en-wikipedia-org-9224 967 2 June June NNP en-wikipedia-org-9224 967 3 2017 2017 CD en-wikipedia-org-9224 967 4 . . . en-wikipedia-org-9224 968 1 Archived archived JJ en-wikipedia-org-9224 968 2 from from IN en-wikipedia-org-9224 968 3 the the DT en-wikipedia-org-9224 968 4 original original NN en-wikipedia-org-9224 968 5 on on IN en-wikipedia-org-9224 968 6 28 28 CD en-wikipedia-org-9224 968 7 July July NNP en-wikipedia-org-9224 968 8 2017 2017 CD en-wikipedia-org-9224 968 9 . . . en-wikipedia-org-9224 969 1 Retrieved retrieve VBN en-wikipedia-org-9224 969 2 17 17 CD en-wikipedia-org-9224 969 3 July July NNP en-wikipedia-org-9224 969 4 2017 2017 CD en-wikipedia-org-9224 969 5 . . . en-wikipedia-org-9224 970 1 This this DT en-wikipedia-org-9224 970 2 article article NN en-wikipedia-org-9224 970 3 incorporates incorporate VBZ en-wikipedia-org-9224 970 4 text text NN en-wikipedia-org-9224 970 5 from from IN en-wikipedia-org-9224 970 6 this this DT en-wikipedia-org-9224 970 7 source source NN en-wikipedia-org-9224 970 8 , , , en-wikipedia-org-9224 970 9 which which WDT en-wikipedia-org-9224 970 10 is be VBZ en-wikipedia-org-9224 970 11 in in IN en-wikipedia-org-9224 970 12 the the DT en-wikipedia-org-9224 970 13 public public JJ en-wikipedia-org-9224 970 14 domain domain NN en-wikipedia-org-9224 970 15 . . . en-wikipedia-org-9224 971 1 ^ ^ NNP en-wikipedia-org-9224 971 2 Smolen Smolen NNP en-wikipedia-org-9224 971 3 JS JS NNP en-wikipedia-org-9224 971 4 , , , en-wikipedia-org-9224 971 5 Aletaha Aletaha NNP en-wikipedia-org-9224 971 6 D D NNP en-wikipedia-org-9224 971 7 , , , en-wikipedia-org-9224 971 8 McInnes McInnes NNP en-wikipedia-org-9224 971 9 IB IB NNP en-wikipedia-org-9224 971 10 ( ( -LRB- en-wikipedia-org-9224 971 11 October October NNP en-wikipedia-org-9224 971 12 2016 2016 CD en-wikipedia-org-9224 971 13 ) ) -RRB- en-wikipedia-org-9224 971 14 . . . en-wikipedia-org-9224 972 1 " " `` en-wikipedia-org-9224 972 2 Rheumatoid Rheumatoid NNP en-wikipedia-org-9224 972 3 arthritis arthritis NN en-wikipedia-org-9224 972 4 " " '' en-wikipedia-org-9224 972 5 ( ( -LRB- en-wikipedia-org-9224 972 6 PDF PDF NNP en-wikipedia-org-9224 972 7 ) ) -RRB- en-wikipedia-org-9224 972 8 . . . en-wikipedia-org-9224 973 1 Lancet Lancet NNP en-wikipedia-org-9224 973 2 . . . en-wikipedia-org-9224 974 1 388 388 CD en-wikipedia-org-9224 974 2 ( ( -LRB- en-wikipedia-org-9224 974 3 10055 10055 CD en-wikipedia-org-9224 974 4 ) ) -RRB- en-wikipedia-org-9224 974 5 : : : en-wikipedia-org-9224 974 6 2023–2038 2023–2038 CD en-wikipedia-org-9224 974 7 . . . en-wikipedia-org-9224 975 1 doi:10.1016 doi:10.1016 JJ en-wikipedia-org-9224 975 2 / / SYM en-wikipedia-org-9224 975 3 S0140 S0140 NNP en-wikipedia-org-9224 975 4 - - HYPH en-wikipedia-org-9224 975 5 6736(16)30173 6736(16)30173 NNP en-wikipedia-org-9224 975 6 - - HYPH en-wikipedia-org-9224 975 7 8 8 NNP en-wikipedia-org-9224 975 8 . . . en-wikipedia-org-9224 976 1 PMID PMID NNP en-wikipedia-org-9224 976 2   _SP en-wikipedia-org-9224 976 3 27156434 27156434 CD en-wikipedia-org-9224 976 4 . . . en-wikipedia-org-9224 977 1 S2CID S2CID NNS en-wikipedia-org-9224 977 2   _SP en-wikipedia-org-9224 977 3 37973054 37973054 CD en-wikipedia-org-9224 977 4 . . . en-wikipedia-org-9224 978 1 ^ ^ NNP en-wikipedia-org-9224 978 2 Farhy Farhy NNP en-wikipedia-org-9224 978 3 LS LS NNP en-wikipedia-org-9224 978 4 , , , en-wikipedia-org-9224 978 5 McCall McCall NNP en-wikipedia-org-9224 978 6 AL AL NNP en-wikipedia-org-9224 978 7 ( ( -LRB- en-wikipedia-org-9224 978 8 July July NNP en-wikipedia-org-9224 978 9 2015 2015 CD en-wikipedia-org-9224 978 10 ) ) -RRB- en-wikipedia-org-9224 978 11 . . . en-wikipedia-org-9224 979 1 " " `` en-wikipedia-org-9224 979 2 Glucagon Glucagon NNP en-wikipedia-org-9224 979 3 - - : en-wikipedia-org-9224 979 4 the the DT en-wikipedia-org-9224 979 5 new new JJ en-wikipedia-org-9224 979 6 ' ' `` en-wikipedia-org-9224 979 7 insulin insulin NN en-wikipedia-org-9224 979 8 ' ' '' en-wikipedia-org-9224 979 9 in in IN en-wikipedia-org-9224 979 10 the the DT en-wikipedia-org-9224 979 11 pathophysiology pathophysiology NN en-wikipedia-org-9224 979 12 of of IN en-wikipedia-org-9224 979 13 diabetes diabetes NN en-wikipedia-org-9224 979 14 " " '' en-wikipedia-org-9224 979 15 . . . en-wikipedia-org-9224 980 1 Current current JJ en-wikipedia-org-9224 980 2 Opinion Opinion NNP en-wikipedia-org-9224 980 3 in in IN en-wikipedia-org-9224 980 4 Clinical Clinical NNP en-wikipedia-org-9224 980 5 Nutrition Nutrition NNP en-wikipedia-org-9224 980 6 and and CC en-wikipedia-org-9224 980 7 Metabolic Metabolic NNP en-wikipedia-org-9224 980 8 Care Care NNP en-wikipedia-org-9224 980 9 . . . en-wikipedia-org-9224 981 1 18 18 CD en-wikipedia-org-9224 981 2 ( ( -LRB- en-wikipedia-org-9224 981 3 4 4 CD en-wikipedia-org-9224 981 4 ) ) -RRB- en-wikipedia-org-9224 981 5 : : : en-wikipedia-org-9224 981 6 407–14 407–14 CD en-wikipedia-org-9224 981 7 . . . en-wikipedia-org-9224 982 1 doi:10.1097 doi:10.1097 NNP en-wikipedia-org-9224 982 2 / / SYM en-wikipedia-org-9224 982 3 mco.0000000000000192 mco.0000000000000192 CD en-wikipedia-org-9224 982 4 . . . en-wikipedia-org-9224 983 1 PMID PMID NNP en-wikipedia-org-9224 983 2   _SP en-wikipedia-org-9224 983 3 26049639 26049639 CD en-wikipedia-org-9224 983 4 . . . en-wikipedia-org-9224 984 1 S2CID S2CID NNS en-wikipedia-org-9224 984 2   _SP en-wikipedia-org-9224 984 3 19872862 19872862 CD en-wikipedia-org-9224 984 4 . . . en-wikipedia-org-9224 985 1 ^ ^ FW en-wikipedia-org-9224 985 2 " " `` en-wikipedia-org-9224 985 3 Handout Handout NNP en-wikipedia-org-9224 985 4 on on IN en-wikipedia-org-9224 985 5 Health Health NNP en-wikipedia-org-9224 985 6 : : : en-wikipedia-org-9224 985 7 Systemic Systemic NNP en-wikipedia-org-9224 985 8 Lupus Lupus NNP en-wikipedia-org-9224 985 9 Erythematosus Erythematosus NNP en-wikipedia-org-9224 985 10 " " '' en-wikipedia-org-9224 985 11 . . . en-wikipedia-org-9224 986 1 www.niams.nih.gov www.niams.nih.gov NNP en-wikipedia-org-9224 986 2 . . . en-wikipedia-org-9224 987 1 February February NNP en-wikipedia-org-9224 987 2 2015 2015 CD en-wikipedia-org-9224 987 3 . . . en-wikipedia-org-9224 988 1 Archived archived JJ en-wikipedia-org-9224 988 2 from from IN en-wikipedia-org-9224 988 3 the the DT en-wikipedia-org-9224 988 4 original original NN en-wikipedia-org-9224 988 5 on on IN en-wikipedia-org-9224 988 6 17 17 CD en-wikipedia-org-9224 988 7 June June NNP en-wikipedia-org-9224 988 8 2016 2016 CD en-wikipedia-org-9224 988 9 . . . en-wikipedia-org-9224 989 1 Retrieved Retrieved NNP en-wikipedia-org-9224 989 2 12 12 CD en-wikipedia-org-9224 989 3 June June NNP en-wikipedia-org-9224 989 4 2016 2016 CD en-wikipedia-org-9224 989 5 . . . en-wikipedia-org-9224 990 1 ^ ^ NNP en-wikipedia-org-9224 990 2 a a DT en-wikipedia-org-9224 990 3 b b NN en-wikipedia-org-9224 990 4 c c NNP en-wikipedia-org-9224 990 5 d d NN en-wikipedia-org-9224 990 6 Ghaffar Ghaffar NNP en-wikipedia-org-9224 990 7 A A NNP en-wikipedia-org-9224 990 8 ( ( -LRB- en-wikipedia-org-9224 990 9 2006 2006 CD en-wikipedia-org-9224 990 10 ) ) -RRB- en-wikipedia-org-9224 990 11 . . . en-wikipedia-org-9224 991 1 " " `` en-wikipedia-org-9224 991 2 Immunology immunology NN en-wikipedia-org-9224 991 3   _SP en-wikipedia-org-9224 991 4 – – : en-wikipedia-org-9224 991 5 Chapter Chapter NNP en-wikipedia-org-9224 991 6 Seventeen Seventeen NNP en-wikipedia-org-9224 991 7 : : : en-wikipedia-org-9224 991 8 Hypersensitivity Hypersensitivity NNP en-wikipedia-org-9224 991 9 States States NNP en-wikipedia-org-9224 991 10 " " '' en-wikipedia-org-9224 991 11 . . . en-wikipedia-org-9224 992 1 Microbiology microbiology RB en-wikipedia-org-9224 992 2 and and CC en-wikipedia-org-9224 992 3 Immunology Immunology NNP en-wikipedia-org-9224 992 4 On on NN en-wikipedia-org-9224 992 5 - - HYPH en-wikipedia-org-9224 992 6 line line NN en-wikipedia-org-9224 992 7 . . . en-wikipedia-org-9224 993 1 University University NNP en-wikipedia-org-9224 993 2 of of IN en-wikipedia-org-9224 993 3 South South NNP en-wikipedia-org-9224 993 4 Carolina Carolina NNP en-wikipedia-org-9224 993 5 School School NNP en-wikipedia-org-9224 993 6 of of IN en-wikipedia-org-9224 993 7 Medicine Medicine NNP en-wikipedia-org-9224 993 8 . . . en-wikipedia-org-9224 994 1 Retrieved retrieve VBN en-wikipedia-org-9224 994 2 29 29 CD en-wikipedia-org-9224 994 3 May May NNP en-wikipedia-org-9224 994 4 2016 2016 CD en-wikipedia-org-9224 994 5 . . . en-wikipedia-org-9224 995 1 ^ ^ NNP en-wikipedia-org-9224 995 2 Sompayrac Sompayrac NNP en-wikipedia-org-9224 995 3 2019 2019 CD en-wikipedia-org-9224 995 4 , , , en-wikipedia-org-9224 995 5 pp pp NNP en-wikipedia-org-9224 995 6 . . . en-wikipedia-org-9224 996 1 83–85 83–85 CD en-wikipedia-org-9224 996 2 . . . en-wikipedia-org-9224 997 1 ^ ^ NNP en-wikipedia-org-9224 997 2 a a DT en-wikipedia-org-9224 997 3 b b NN en-wikipedia-org-9224 997 4 Taylor Taylor NNP en-wikipedia-org-9224 997 5 AL AL NNP en-wikipedia-org-9224 997 6 , , , en-wikipedia-org-9224 997 7 Watson Watson NNP en-wikipedia-org-9224 997 8 CJ CJ NNP en-wikipedia-org-9224 997 9 , , , en-wikipedia-org-9224 997 10 Bradley Bradley NNP en-wikipedia-org-9224 997 11 JA JA NNP en-wikipedia-org-9224 997 12 ( ( -LRB- en-wikipedia-org-9224 997 13 October October NNP en-wikipedia-org-9224 997 14 2005 2005 CD en-wikipedia-org-9224 997 15 ) ) -RRB- en-wikipedia-org-9224 997 16 . . . en-wikipedia-org-9224 998 1 " " `` en-wikipedia-org-9224 998 2 Immunosuppressive immunosuppressive JJ en-wikipedia-org-9224 998 3 agents agent NNS en-wikipedia-org-9224 998 4 in in IN en-wikipedia-org-9224 998 5 solid solid JJ en-wikipedia-org-9224 998 6 organ organ NN en-wikipedia-org-9224 998 7 transplantation transplantation NN en-wikipedia-org-9224 998 8 : : : en-wikipedia-org-9224 998 9 Mechanisms mechanism NNS en-wikipedia-org-9224 998 10 of of IN en-wikipedia-org-9224 998 11 action action NN en-wikipedia-org-9224 998 12 and and CC en-wikipedia-org-9224 998 13 therapeutic therapeutic JJ en-wikipedia-org-9224 998 14 efficacy efficacy NN en-wikipedia-org-9224 998 15 " " '' en-wikipedia-org-9224 998 16 . . . en-wikipedia-org-9224 999 1 Critical Critical NNP en-wikipedia-org-9224 999 2 Reviews Reviews NNPS en-wikipedia-org-9224 999 3 in in IN en-wikipedia-org-9224 999 4 Oncology Oncology NNP en-wikipedia-org-9224 999 5 / / SYM en-wikipedia-org-9224 999 6 Hematology Hematology NNP en-wikipedia-org-9224 999 7 . . . en-wikipedia-org-9224 1000 1 56 56 CD en-wikipedia-org-9224 1000 2 ( ( -LRB- en-wikipedia-org-9224 1000 3 1 1 CD en-wikipedia-org-9224 1000 4 ) ) -RRB- en-wikipedia-org-9224 1000 5 : : : en-wikipedia-org-9224 1000 6 23–46 23–46 CD en-wikipedia-org-9224 1000 7 . . . en-wikipedia-org-9224 1001 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 1001 2 / / SYM en-wikipedia-org-9224 1001 3 j.critrevonc.2005.03.012 j.critrevonc.2005.03.012 CD en-wikipedia-org-9224 1001 4 . . . en-wikipedia-org-9224 1002 1 PMID PMID NNP en-wikipedia-org-9224 1002 2   _SP en-wikipedia-org-9224 1002 3 16039869 16039869 CD en-wikipedia-org-9224 1002 4 . . . en-wikipedia-org-9224 1003 1 ^ ^ NN en-wikipedia-org-9224 1003 2 Barnes Barnes NNPS en-wikipedia-org-9224 1003 3 PJ PJ NNP en-wikipedia-org-9224 1003 4 ( ( -LRB- en-wikipedia-org-9224 1003 5 March March NNP en-wikipedia-org-9224 1003 6 2006 2006 CD en-wikipedia-org-9224 1003 7 ) ) -RRB- en-wikipedia-org-9224 1003 8 . . . en-wikipedia-org-9224 1004 1 " " `` en-wikipedia-org-9224 1004 2 Corticosteroids corticosteroid NNS en-wikipedia-org-9224 1004 3 : : : en-wikipedia-org-9224 1004 4 the the DT en-wikipedia-org-9224 1004 5 drugs drug NNS en-wikipedia-org-9224 1004 6 to to TO en-wikipedia-org-9224 1004 7 beat beat VB en-wikipedia-org-9224 1004 8 " " '' en-wikipedia-org-9224 1004 9 . . . en-wikipedia-org-9224 1005 1 European European NNP en-wikipedia-org-9224 1005 2 Journal Journal NNP en-wikipedia-org-9224 1005 3 of of IN en-wikipedia-org-9224 1005 4 Pharmacology Pharmacology NNP en-wikipedia-org-9224 1005 5 . . . en-wikipedia-org-9224 1006 1 533 533 CD en-wikipedia-org-9224 1006 2 ( ( -LRB- en-wikipedia-org-9224 1006 3 1–3 1–3 CD en-wikipedia-org-9224 1006 4 ) ) -RRB- en-wikipedia-org-9224 1006 5 : : : en-wikipedia-org-9224 1006 6 2–14 2–14 CD en-wikipedia-org-9224 1006 7 . . . en-wikipedia-org-9224 1007 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 1007 2 / / SYM en-wikipedia-org-9224 1007 3 j.ejphar.2005.12.052 j.ejphar.2005.12.052 CD en-wikipedia-org-9224 1007 4 . . . en-wikipedia-org-9224 1008 1 PMID PMID NNP en-wikipedia-org-9224 1008 2   _SP en-wikipedia-org-9224 1008 3 16436275 16436275 CD en-wikipedia-org-9224 1008 4 . . . en-wikipedia-org-9224 1009 1 ^ ^ NNP en-wikipedia-org-9224 1009 2 Masri Masri NNP en-wikipedia-org-9224 1009 3 MA MA NNP en-wikipedia-org-9224 1009 4 ( ( -LRB- en-wikipedia-org-9224 1009 5 July July NNP en-wikipedia-org-9224 1009 6 2003 2003 CD en-wikipedia-org-9224 1009 7 ) ) -RRB- en-wikipedia-org-9224 1009 8 . . . en-wikipedia-org-9224 1010 1 " " `` en-wikipedia-org-9224 1010 2 The the DT en-wikipedia-org-9224 1010 3 mosaic mosaic JJ en-wikipedia-org-9224 1010 4 of of IN en-wikipedia-org-9224 1010 5 immunosuppressive immunosuppressive JJ en-wikipedia-org-9224 1010 6 drugs drug NNS en-wikipedia-org-9224 1010 7 " " '' en-wikipedia-org-9224 1010 8 . . . en-wikipedia-org-9224 1011 1 Molecular Molecular NNP en-wikipedia-org-9224 1011 2 Immunology Immunology NNP en-wikipedia-org-9224 1011 3 . . . en-wikipedia-org-9224 1012 1 39 39 CD en-wikipedia-org-9224 1012 2 ( ( -LRB- en-wikipedia-org-9224 1012 3 17–18 17–18 CD en-wikipedia-org-9224 1012 4 ) ) -RRB- en-wikipedia-org-9224 1012 5 : : : en-wikipedia-org-9224 1012 6 1073–77 1073–77 LS en-wikipedia-org-9224 1012 7 . . . en-wikipedia-org-9224 1013 1 doi:10.1016 doi:10.1016 JJ en-wikipedia-org-9224 1013 2 / / SYM en-wikipedia-org-9224 1013 3 S0161 s0161 JJ en-wikipedia-org-9224 1013 4 - - HYPH en-wikipedia-org-9224 1013 5 5890(03)00075 5890(03)00075 NNP en-wikipedia-org-9224 1013 6 - - HYPH en-wikipedia-org-9224 1013 7 0 0 CD en-wikipedia-org-9224 1013 8 . . . en-wikipedia-org-9224 1014 1 PMID PMID NNP en-wikipedia-org-9224 1014 2   _SP en-wikipedia-org-9224 1014 3 12835079 12835079 CD en-wikipedia-org-9224 1014 4 . . . en-wikipedia-org-9224 1015 1 ^ ^ NNP en-wikipedia-org-9224 1015 2 a a DT en-wikipedia-org-9224 1015 3 b b NN en-wikipedia-org-9224 1015 4 Reece Reece NNP en-wikipedia-org-9224 1015 5 2011 2011 CD en-wikipedia-org-9224 1015 6 , , , en-wikipedia-org-9224 1015 7 p. p. NN en-wikipedia-org-9224 1015 8   _SP en-wikipedia-org-9224 1015 9 965 965 CD en-wikipedia-org-9224 1015 10 . . . en-wikipedia-org-9224 1016 1 ^ ^ NFP en-wikipedia-org-9224 1016 2 Death death NN en-wikipedia-org-9224 1016 3 and and CC en-wikipedia-org-9224 1016 4 DALY DALY NNP en-wikipedia-org-9224 1016 5 estimates estimate NNS en-wikipedia-org-9224 1016 6 for for IN en-wikipedia-org-9224 1016 7 2002 2002 CD en-wikipedia-org-9224 1016 8 by by IN en-wikipedia-org-9224 1016 9 cause cause NN en-wikipedia-org-9224 1016 10 for for IN en-wikipedia-org-9224 1016 11 WHO who WP en-wikipedia-org-9224 1016 12 Member Member NNP en-wikipedia-org-9224 1016 13 States States NNP en-wikipedia-org-9224 1016 14 . . . en-wikipedia-org-9224 1017 1 World World NNP en-wikipedia-org-9224 1017 2 Health Health NNP en-wikipedia-org-9224 1017 3 Organization Organization NNP en-wikipedia-org-9224 1017 4 . . . en-wikipedia-org-9224 1018 1 Retrieved retrieve VBN en-wikipedia-org-9224 1018 2 on on IN en-wikipedia-org-9224 1018 3 1 1 CD en-wikipedia-org-9224 1018 4 January January NNP en-wikipedia-org-9224 1018 5 2007 2007 CD en-wikipedia-org-9224 1018 6 . . . en-wikipedia-org-9224 1019 1 ^ ^ NNP en-wikipedia-org-9224 1019 2 Singh Singh NNP en-wikipedia-org-9224 1019 3 M M NNP en-wikipedia-org-9224 1019 4 , , , en-wikipedia-org-9224 1019 5 O'Hagan O'Hagan NNP en-wikipedia-org-9224 1019 6 D D NNP en-wikipedia-org-9224 1019 7 ( ( -LRB- en-wikipedia-org-9224 1019 8 November November NNP en-wikipedia-org-9224 1019 9 1999 1999 CD en-wikipedia-org-9224 1019 10 ) ) -RRB- en-wikipedia-org-9224 1019 11 . . . en-wikipedia-org-9224 1020 1 " " `` en-wikipedia-org-9224 1020 2 Advances advance NNS en-wikipedia-org-9224 1020 3 in in IN en-wikipedia-org-9224 1020 4 vaccine vaccine NN en-wikipedia-org-9224 1020 5 adjuvants adjuvant NNS en-wikipedia-org-9224 1020 6 " " '' en-wikipedia-org-9224 1020 7 . . . en-wikipedia-org-9224 1021 1 Nature Nature NNP en-wikipedia-org-9224 1021 2 Biotechnology Biotechnology NNP en-wikipedia-org-9224 1021 3 . . . en-wikipedia-org-9224 1022 1 17 17 CD en-wikipedia-org-9224 1022 2 ( ( -LRB- en-wikipedia-org-9224 1022 3 11 11 CD en-wikipedia-org-9224 1022 4 ) ) -RRB- en-wikipedia-org-9224 1022 5 : : : en-wikipedia-org-9224 1022 6 1075–81 1075–81 LS en-wikipedia-org-9224 1022 7 . . . en-wikipedia-org-9224 1023 1 doi:10.1038/15058 doi:10.1038/15058 FW en-wikipedia-org-9224 1023 2 . . . en-wikipedia-org-9224 1024 1 PMID PMID NNP en-wikipedia-org-9224 1024 2   _SP en-wikipedia-org-9224 1024 3 10545912 10545912 CD en-wikipedia-org-9224 1024 4 . . . en-wikipedia-org-9224 1025 1 S2CID S2CID NNS en-wikipedia-org-9224 1025 2   _SP en-wikipedia-org-9224 1025 3 21346647 21346647 CD en-wikipedia-org-9224 1025 4 . . . en-wikipedia-org-9224 1026 1 ^ ^ NNP en-wikipedia-org-9224 1026 2 a a DT en-wikipedia-org-9224 1026 3 b b NNP en-wikipedia-org-9224 1026 4 Andersen Andersen NNP en-wikipedia-org-9224 1026 5 MH MH NNP en-wikipedia-org-9224 1026 6 , , , en-wikipedia-org-9224 1026 7 Schrama Schrama NNP en-wikipedia-org-9224 1026 8 D D NNP en-wikipedia-org-9224 1026 9 , , , en-wikipedia-org-9224 1026 10 Thor Thor NNP en-wikipedia-org-9224 1026 11 Straten Straten NNP en-wikipedia-org-9224 1026 12 P P NNP en-wikipedia-org-9224 1026 13 , , , en-wikipedia-org-9224 1026 14 Becker Becker NNP en-wikipedia-org-9224 1026 15 JC JC NNP en-wikipedia-org-9224 1026 16 ( ( -LRB- en-wikipedia-org-9224 1026 17 January January NNP en-wikipedia-org-9224 1026 18 2006 2006 CD en-wikipedia-org-9224 1026 19 ) ) -RRB- en-wikipedia-org-9224 1026 20 . . . en-wikipedia-org-9224 1027 1 " " `` en-wikipedia-org-9224 1027 2 Cytotoxic cytotoxic JJ en-wikipedia-org-9224 1027 3 T t NN en-wikipedia-org-9224 1027 4 cells cell NNS en-wikipedia-org-9224 1027 5 " " '' en-wikipedia-org-9224 1027 6 . . . en-wikipedia-org-9224 1028 1 The the DT en-wikipedia-org-9224 1028 2 Journal Journal NNP en-wikipedia-org-9224 1028 3 of of IN en-wikipedia-org-9224 1028 4 Investigative Investigative NNP en-wikipedia-org-9224 1028 5 Dermatology Dermatology NNP en-wikipedia-org-9224 1028 6 . . . en-wikipedia-org-9224 1029 1 126 126 CD en-wikipedia-org-9224 1029 2 ( ( -LRB- en-wikipedia-org-9224 1029 3 1 1 CD en-wikipedia-org-9224 1029 4 ) ) -RRB- en-wikipedia-org-9224 1029 5 : : : en-wikipedia-org-9224 1029 6 32–41 32–41 CD en-wikipedia-org-9224 1029 7 . . . en-wikipedia-org-9224 1030 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 1030 2 / / SYM en-wikipedia-org-9224 1030 3 sj.jid.5700001 sj.jid.5700001 NNP en-wikipedia-org-9224 1030 4 . . . en-wikipedia-org-9224 1031 1 PMID PMID NNP en-wikipedia-org-9224 1031 2   _SP en-wikipedia-org-9224 1031 3 16417215 16417215 CD en-wikipedia-org-9224 1031 4 . . . en-wikipedia-org-9224 1032 1 ^ ^ NNP en-wikipedia-org-9224 1032 2 Boon Boon NNP en-wikipedia-org-9224 1032 3 T T NNP en-wikipedia-org-9224 1032 4 , , , en-wikipedia-org-9224 1032 5 van van NNP en-wikipedia-org-9224 1032 6 der der NN en-wikipedia-org-9224 1032 7 Bruggen Bruggen NNP en-wikipedia-org-9224 1032 8 P P NNP en-wikipedia-org-9224 1032 9 ( ( -LRB- en-wikipedia-org-9224 1032 10 March March NNP en-wikipedia-org-9224 1032 11 1996 1996 CD en-wikipedia-org-9224 1032 12 ) ) -RRB- en-wikipedia-org-9224 1032 13 . . . en-wikipedia-org-9224 1033 1 " " `` en-wikipedia-org-9224 1033 2 Human human JJ en-wikipedia-org-9224 1033 3 tumor tumor NN en-wikipedia-org-9224 1033 4 antigens antigen NNS en-wikipedia-org-9224 1033 5 recognized recognize VBN en-wikipedia-org-9224 1033 6 by by IN en-wikipedia-org-9224 1033 7 T T NNP en-wikipedia-org-9224 1033 8 lymphocytes lymphocyte NNS en-wikipedia-org-9224 1033 9 " " '' en-wikipedia-org-9224 1033 10 . . . en-wikipedia-org-9224 1034 1 The the DT en-wikipedia-org-9224 1034 2 Journal Journal NNP en-wikipedia-org-9224 1034 3 of of IN en-wikipedia-org-9224 1034 4 Experimental Experimental NNP en-wikipedia-org-9224 1034 5 Medicine Medicine NNP en-wikipedia-org-9224 1034 6 . . . en-wikipedia-org-9224 1035 1 183 183 CD en-wikipedia-org-9224 1035 2 ( ( -LRB- en-wikipedia-org-9224 1035 3 3 3 CD en-wikipedia-org-9224 1035 4 ) ) -RRB- en-wikipedia-org-9224 1035 5 : : : en-wikipedia-org-9224 1035 6 725–29 725–29 CD en-wikipedia-org-9224 1035 7 . . . en-wikipedia-org-9224 1036 1 doi:10.1084 doi:10.1084 VB en-wikipedia-org-9224 1036 2 / / SYM en-wikipedia-org-9224 1036 3 jem.183.3.725 jem.183.3.725 NNS en-wikipedia-org-9224 1036 4 . . . en-wikipedia-org-9224 1037 1 PMC PMC NNP en-wikipedia-org-9224 1037 2   _SP en-wikipedia-org-9224 1037 3 2192342 2192342 CD en-wikipedia-org-9224 1037 4 . . . en-wikipedia-org-9224 1038 1 PMID PMID NNP en-wikipedia-org-9224 1038 2   _SP en-wikipedia-org-9224 1038 3 8642276 8642276 CD en-wikipedia-org-9224 1038 4 . . . en-wikipedia-org-9224 1039 1 ^ ^ NFP en-wikipedia-org-9224 1039 2 Ljubojevic Ljubojevic NNP en-wikipedia-org-9224 1039 3 S S NNP en-wikipedia-org-9224 1039 4 , , , en-wikipedia-org-9224 1039 5 Skerlev Skerlev NNP en-wikipedia-org-9224 1039 6 M M NNP en-wikipedia-org-9224 1039 7 ( ( -LRB- en-wikipedia-org-9224 1039 8 2014 2014 CD en-wikipedia-org-9224 1039 9 ) ) -RRB- en-wikipedia-org-9224 1039 10 . . . en-wikipedia-org-9224 1040 1 " " `` en-wikipedia-org-9224 1040 2 HPV hpv NN en-wikipedia-org-9224 1040 3 - - HYPH en-wikipedia-org-9224 1040 4 associated associate VBN en-wikipedia-org-9224 1040 5 diseases disease NNS en-wikipedia-org-9224 1040 6 " " '' en-wikipedia-org-9224 1040 7 . . . en-wikipedia-org-9224 1041 1 Clinics Clinics NNP en-wikipedia-org-9224 1041 2 in in IN en-wikipedia-org-9224 1041 3 Dermatology Dermatology NNP en-wikipedia-org-9224 1041 4 . . . en-wikipedia-org-9224 1042 1 32 32 CD en-wikipedia-org-9224 1042 2 ( ( -LRB- en-wikipedia-org-9224 1042 3 2 2 CD en-wikipedia-org-9224 1042 4 ) ) -RRB- en-wikipedia-org-9224 1042 5 : : : en-wikipedia-org-9224 1042 6 227–34 227–34 CD en-wikipedia-org-9224 1042 7 . . . en-wikipedia-org-9224 1043 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 1043 2 / / SYM en-wikipedia-org-9224 1043 3 j.clindermatol.2013.08.007 j.clindermatol.2013.08.007 NNS en-wikipedia-org-9224 1043 4 . . . en-wikipedia-org-9224 1044 1 PMID PMID NNP en-wikipedia-org-9224 1044 2   _SP en-wikipedia-org-9224 1044 3 24559558 24559558 CD en-wikipedia-org-9224 1044 4 . . . en-wikipedia-org-9224 1045 1 ^ ^ NNP en-wikipedia-org-9224 1045 2 Castelli Castelli NNP en-wikipedia-org-9224 1045 3 C C NNP en-wikipedia-org-9224 1045 4 , , , en-wikipedia-org-9224 1045 5 Rivoltini Rivoltini NNP en-wikipedia-org-9224 1045 6 L L NNP en-wikipedia-org-9224 1045 7 , , , en-wikipedia-org-9224 1045 8 Andreola Andreola NNP en-wikipedia-org-9224 1045 9 G G NNP en-wikipedia-org-9224 1045 10 , , , en-wikipedia-org-9224 1045 11 Carrabba Carrabba NNP en-wikipedia-org-9224 1045 12 M M NNP en-wikipedia-org-9224 1045 13 , , , en-wikipedia-org-9224 1045 14 Renkvist Renkvist NNP en-wikipedia-org-9224 1045 15 N N NNP en-wikipedia-org-9224 1045 16 , , , en-wikipedia-org-9224 1045 17 Parmiani Parmiani NNP en-wikipedia-org-9224 1045 18 G G NNP en-wikipedia-org-9224 1045 19 ( ( -LRB- en-wikipedia-org-9224 1045 20 March March NNP en-wikipedia-org-9224 1045 21 2000 2000 CD en-wikipedia-org-9224 1045 22 ) ) -RRB- en-wikipedia-org-9224 1045 23 . . . en-wikipedia-org-9224 1046 1 " " `` en-wikipedia-org-9224 1046 2 T t NN en-wikipedia-org-9224 1046 3 - - HYPH en-wikipedia-org-9224 1046 4 cell cell NN en-wikipedia-org-9224 1046 5 recognition recognition NN en-wikipedia-org-9224 1046 6 of of IN en-wikipedia-org-9224 1046 7 melanoma melanoma NNP en-wikipedia-org-9224 1046 8 - - HYPH en-wikipedia-org-9224 1046 9 associated associate VBN en-wikipedia-org-9224 1046 10 antigens antigen NNS en-wikipedia-org-9224 1046 11 " " '' en-wikipedia-org-9224 1046 12 . . . en-wikipedia-org-9224 1047 1 Journal Journal NNP en-wikipedia-org-9224 1047 2 of of IN en-wikipedia-org-9224 1047 3 Cellular Cellular NNP en-wikipedia-org-9224 1047 4 Physiology Physiology NNP en-wikipedia-org-9224 1047 5 . . . en-wikipedia-org-9224 1048 1 182 182 CD en-wikipedia-org-9224 1048 2 ( ( -LRB- en-wikipedia-org-9224 1048 3 3 3 CD en-wikipedia-org-9224 1048 4 ) ) -RRB- en-wikipedia-org-9224 1048 5 : : : en-wikipedia-org-9224 1048 6 323–31 323–31 CD en-wikipedia-org-9224 1048 7 . . . en-wikipedia-org-9224 1049 1 doi:10.1002/(SICI)1097 doi:10.1002/(SICI)1097 NNP en-wikipedia-org-9224 1049 2 - - HYPH en-wikipedia-org-9224 1049 3 4652(200003)182:3<323::AID 4652(200003)182:3<323::aid CD en-wikipedia-org-9224 1049 4 - - HYPH en-wikipedia-org-9224 1049 5 JCP2>3.0.CO;2- jcp2>3.0.co;2- NN en-wikipedia-org-9224 1049 6 # # NN en-wikipedia-org-9224 1049 7 . . . en-wikipedia-org-9224 1050 1 PMID PMID NNP en-wikipedia-org-9224 1050 2   _SP en-wikipedia-org-9224 1050 3 10653598 10653598 CD en-wikipedia-org-9224 1050 4 . . . en-wikipedia-org-9224 1051 1 ^ ^ NNP en-wikipedia-org-9224 1051 2 a a DT en-wikipedia-org-9224 1051 3 b b NN en-wikipedia-org-9224 1051 4 Romero Romero NNP en-wikipedia-org-9224 1051 5 P P NNP en-wikipedia-org-9224 1051 6 , , , en-wikipedia-org-9224 1051 7 Cerottini Cerottini NNP en-wikipedia-org-9224 1051 8 JC JC NNP en-wikipedia-org-9224 1051 9 , , , en-wikipedia-org-9224 1051 10 Speiser Speiser NNP en-wikipedia-org-9224 1051 11 DE DE NNP en-wikipedia-org-9224 1051 12 ( ( -LRB- en-wikipedia-org-9224 1051 13 2006 2006 CD en-wikipedia-org-9224 1051 14 ) ) -RRB- en-wikipedia-org-9224 1051 15 . . . en-wikipedia-org-9224 1052 1 " " `` en-wikipedia-org-9224 1052 2 The the DT en-wikipedia-org-9224 1052 3 human human JJ en-wikipedia-org-9224 1052 4 T t JJ en-wikipedia-org-9224 1052 5 cell cell NN en-wikipedia-org-9224 1052 6 response response NN en-wikipedia-org-9224 1052 7 to to IN en-wikipedia-org-9224 1052 8 melanoma melanoma NNP en-wikipedia-org-9224 1052 9 antigens antigen NNS en-wikipedia-org-9224 1052 10 " " '' en-wikipedia-org-9224 1052 11 . . . en-wikipedia-org-9224 1053 1 Advances advance NNS en-wikipedia-org-9224 1053 2 in in IN en-wikipedia-org-9224 1053 3 Immunology immunology NN en-wikipedia-org-9224 1053 4 . . . en-wikipedia-org-9224 1054 1 92 92 CD en-wikipedia-org-9224 1054 2 : : : en-wikipedia-org-9224 1054 3 187–224 187–224 CD en-wikipedia-org-9224 1054 4 . . . en-wikipedia-org-9224 1055 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 1055 2 / / SYM en-wikipedia-org-9224 1055 3 S0065 S0065 NNP en-wikipedia-org-9224 1055 4 - - HYPH en-wikipedia-org-9224 1055 5 2776(06)92005 2776(06)92005 NNP en-wikipedia-org-9224 1055 6 - - HYPH en-wikipedia-org-9224 1055 7 7 7 CD en-wikipedia-org-9224 1055 8 . . . en-wikipedia-org-9224 1056 1 ISBN ISBN NNP en-wikipedia-org-9224 1056 2   _SP en-wikipedia-org-9224 1056 3 978 978 CD en-wikipedia-org-9224 1056 4 - - HYPH en-wikipedia-org-9224 1056 5 0 0 CD en-wikipedia-org-9224 1056 6 - - HYPH en-wikipedia-org-9224 1056 7 12 12 CD en-wikipedia-org-9224 1056 8 - - HYPH en-wikipedia-org-9224 1056 9 373636 373636 CD en-wikipedia-org-9224 1056 10 - - SYM en-wikipedia-org-9224 1056 11 9 9 CD en-wikipedia-org-9224 1056 12 . . . en-wikipedia-org-9224 1057 1 PMID PMID NNP en-wikipedia-org-9224 1057 2   _SP en-wikipedia-org-9224 1057 3 17145305 17145305 CD en-wikipedia-org-9224 1057 4 . . . en-wikipedia-org-9224 1058 1 ^ ^ NNP en-wikipedia-org-9224 1058 2 a a DT en-wikipedia-org-9224 1058 3 b b NNP en-wikipedia-org-9224 1058 4 Guevara Guevara NNP en-wikipedia-org-9224 1058 5 - - HYPH en-wikipedia-org-9224 1058 6 Patiño Patiño NNP en-wikipedia-org-9224 1058 7 JA JA NNP en-wikipedia-org-9224 1058 8 , , , en-wikipedia-org-9224 1058 9 Turk Turk NNP en-wikipedia-org-9224 1058 10 MJ MJ NNP en-wikipedia-org-9224 1058 11 , , , en-wikipedia-org-9224 1058 12 Wolchok Wolchok NNP en-wikipedia-org-9224 1058 13 JD JD NNP en-wikipedia-org-9224 1058 14 , , , en-wikipedia-org-9224 1058 15 Houghton Houghton NNP en-wikipedia-org-9224 1058 16 AN AN NNP en-wikipedia-org-9224 1058 17 ( ( -LRB- en-wikipedia-org-9224 1058 18 2003 2003 CD en-wikipedia-org-9224 1058 19 ) ) -RRB- en-wikipedia-org-9224 1058 20 . . . en-wikipedia-org-9224 1059 1 " " `` en-wikipedia-org-9224 1059 2 Immunity immunity NN en-wikipedia-org-9224 1059 3 to to IN en-wikipedia-org-9224 1059 4 cancer cancer NN en-wikipedia-org-9224 1059 5 through through IN en-wikipedia-org-9224 1059 6 immune immune JJ en-wikipedia-org-9224 1059 7 recognition recognition NN en-wikipedia-org-9224 1059 8 of of IN en-wikipedia-org-9224 1059 9 altered altered JJ en-wikipedia-org-9224 1059 10 self self NN en-wikipedia-org-9224 1059 11 : : : en-wikipedia-org-9224 1059 12 studies study NNS en-wikipedia-org-9224 1059 13 with with IN en-wikipedia-org-9224 1059 14 melanoma melanoma NNP en-wikipedia-org-9224 1059 15 " " '' en-wikipedia-org-9224 1059 16 . . . en-wikipedia-org-9224 1060 1 Advances advance NNS en-wikipedia-org-9224 1060 2 in in IN en-wikipedia-org-9224 1060 3 Cancer Cancer NNP en-wikipedia-org-9224 1060 4 Research Research NNP en-wikipedia-org-9224 1060 5 . . . en-wikipedia-org-9224 1061 1 90 90 CD en-wikipedia-org-9224 1061 2 : : SYM en-wikipedia-org-9224 1061 3 157–77 157–77 CD en-wikipedia-org-9224 1061 4 . . . en-wikipedia-org-9224 1062 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 1062 2 / / SYM en-wikipedia-org-9224 1062 3 S0065 S0065 NNP en-wikipedia-org-9224 1062 4 - - HYPH en-wikipedia-org-9224 1062 5 230X(03)90005 230X(03)90005 NNP en-wikipedia-org-9224 1062 6 - - HYPH en-wikipedia-org-9224 1062 7 4 4 CD en-wikipedia-org-9224 1062 8 . . . en-wikipedia-org-9224 1063 1 ISBN ISBN NNP en-wikipedia-org-9224 1063 2   _SP en-wikipedia-org-9224 1063 3 978 978 CD en-wikipedia-org-9224 1063 4 - - HYPH en-wikipedia-org-9224 1063 5 0 0 CD en-wikipedia-org-9224 1063 6 - - HYPH en-wikipedia-org-9224 1063 7 12 12 CD en-wikipedia-org-9224 1063 8 - - HYPH en-wikipedia-org-9224 1063 9 006690 006690 CD en-wikipedia-org-9224 1063 10 - - HYPH en-wikipedia-org-9224 1063 11 2 2 CD en-wikipedia-org-9224 1063 12 . . . en-wikipedia-org-9224 1064 1 PMID PMID NNP en-wikipedia-org-9224 1064 2   _SP en-wikipedia-org-9224 1064 3 14710950 14710950 CD en-wikipedia-org-9224 1064 4 . . . en-wikipedia-org-9224 1065 1 ^ ^ NFP en-wikipedia-org-9224 1065 2 Renkvist Renkvist NNP en-wikipedia-org-9224 1065 3 N N NNP en-wikipedia-org-9224 1065 4 , , , en-wikipedia-org-9224 1065 5 Castelli Castelli NNP en-wikipedia-org-9224 1065 6 C C NNP en-wikipedia-org-9224 1065 7 , , , en-wikipedia-org-9224 1065 8 Robbins Robbins NNP en-wikipedia-org-9224 1065 9 PF PF NNP en-wikipedia-org-9224 1065 10 , , , en-wikipedia-org-9224 1065 11 Parmiani Parmiani NNP en-wikipedia-org-9224 1065 12 G G NNP en-wikipedia-org-9224 1065 13 ( ( -LRB- en-wikipedia-org-9224 1065 14 March March NNP en-wikipedia-org-9224 1065 15 2001 2001 CD en-wikipedia-org-9224 1065 16 ) ) -RRB- en-wikipedia-org-9224 1065 17 . . . en-wikipedia-org-9224 1066 1 " " `` en-wikipedia-org-9224 1066 2 A a DT en-wikipedia-org-9224 1066 3 listing listing NN en-wikipedia-org-9224 1066 4 of of IN en-wikipedia-org-9224 1066 5 human human JJ en-wikipedia-org-9224 1066 6 tumor tumor NN en-wikipedia-org-9224 1066 7 antigens antigen NNS en-wikipedia-org-9224 1066 8 recognized recognize VBN en-wikipedia-org-9224 1066 9 by by IN en-wikipedia-org-9224 1066 10 T t NN en-wikipedia-org-9224 1066 11 cells cell NNS en-wikipedia-org-9224 1066 12 " " '' en-wikipedia-org-9224 1066 13 . . . en-wikipedia-org-9224 1067 1 Cancer Cancer NNP en-wikipedia-org-9224 1067 2 Immunology Immunology NNP en-wikipedia-org-9224 1067 3 , , , en-wikipedia-org-9224 1067 4 Immunotherapy Immunotherapy NNP en-wikipedia-org-9224 1067 5 . . . en-wikipedia-org-9224 1068 1 50 50 CD en-wikipedia-org-9224 1068 2 ( ( -LRB- en-wikipedia-org-9224 1068 3 1 1 CD en-wikipedia-org-9224 1068 4 ) ) -RRB- en-wikipedia-org-9224 1068 5 : : : en-wikipedia-org-9224 1068 6 3–15 3–15 CD en-wikipedia-org-9224 1068 7 . . . en-wikipedia-org-9224 1069 1 doi:10.1007 doi:10.1007 NNP en-wikipedia-org-9224 1069 2 / / SYM en-wikipedia-org-9224 1069 3 s002620000169 s002620000169 NNP en-wikipedia-org-9224 1069 4 . . . en-wikipedia-org-9224 1070 1 PMID PMID NNP en-wikipedia-org-9224 1070 2   _SP en-wikipedia-org-9224 1070 3 11315507 11315507 CD en-wikipedia-org-9224 1070 4 . . . en-wikipedia-org-9224 1071 1 S2CID S2CID NNS en-wikipedia-org-9224 1071 2   _SP en-wikipedia-org-9224 1071 3 42681479 42681479 CD en-wikipedia-org-9224 1071 4 . . . en-wikipedia-org-9224 1072 1 ^ ^ NN en-wikipedia-org-9224 1072 2 Morgan Morgan NNP en-wikipedia-org-9224 1072 3 RA RA NNP en-wikipedia-org-9224 1072 4 , , , en-wikipedia-org-9224 1072 5 Dudley Dudley NNP en-wikipedia-org-9224 1072 6 ME ME NNP en-wikipedia-org-9224 1072 7 , , , en-wikipedia-org-9224 1072 8 Wunderlich Wunderlich NNP en-wikipedia-org-9224 1072 9 JR JR NNP en-wikipedia-org-9224 1072 10 , , , en-wikipedia-org-9224 1072 11 et et NNP en-wikipedia-org-9224 1072 12 al al NNP en-wikipedia-org-9224 1072 13 . . . en-wikipedia-org-9224 1073 1 ( ( -LRB- en-wikipedia-org-9224 1073 2 October October NNP en-wikipedia-org-9224 1073 3 2006 2006 CD en-wikipedia-org-9224 1073 4 ) ) -RRB- en-wikipedia-org-9224 1073 5 . . . en-wikipedia-org-9224 1074 1 " " `` en-wikipedia-org-9224 1074 2 Cancer Cancer NNP en-wikipedia-org-9224 1074 3 Regression Regression NNP en-wikipedia-org-9224 1074 4 in in IN en-wikipedia-org-9224 1074 5 Patients Patients NNP en-wikipedia-org-9224 1074 6 After after IN en-wikipedia-org-9224 1074 7 Transfer Transfer NNP en-wikipedia-org-9224 1074 8 of of IN en-wikipedia-org-9224 1074 9 Genetically Genetically NNP en-wikipedia-org-9224 1074 10 Engineered engineer VBN en-wikipedia-org-9224 1074 11 Lymphocytes Lymphocytes NNPS en-wikipedia-org-9224 1074 12 " " '' en-wikipedia-org-9224 1074 13 . . . en-wikipedia-org-9224 1075 1 Science science NN en-wikipedia-org-9224 1075 2 . . . en-wikipedia-org-9224 1076 1 314 314 CD en-wikipedia-org-9224 1076 2 ( ( -LRB- en-wikipedia-org-9224 1076 3 5796 5796 CD en-wikipedia-org-9224 1076 4 ) ) -RRB- en-wikipedia-org-9224 1076 5 : : : en-wikipedia-org-9224 1076 6 126–29 126–29 CD en-wikipedia-org-9224 1076 7 . . . en-wikipedia-org-9224 1077 1 Bibcode:2006Sci bibcode:2006sci UH en-wikipedia-org-9224 1077 2 ... ... : en-wikipedia-org-9224 1077 3 314 314 CD en-wikipedia-org-9224 1077 4 .. .. NFP en-wikipedia-org-9224 1077 5 126M. 126m. CD en-wikipedia-org-9224 1078 1 doi:10.1126 doi:10.1126 VB en-wikipedia-org-9224 1078 2 / / SYM en-wikipedia-org-9224 1078 3 science.1129003 science.1129003 NNP en-wikipedia-org-9224 1078 4 . . . en-wikipedia-org-9224 1079 1 PMC PMC NNP en-wikipedia-org-9224 1079 2   _SP en-wikipedia-org-9224 1079 3 2267026 2267026 CD en-wikipedia-org-9224 1079 4 . . . en-wikipedia-org-9224 1080 1 PMID PMID NNP en-wikipedia-org-9224 1080 2   _SP en-wikipedia-org-9224 1080 3 16946036 16946036 CD en-wikipedia-org-9224 1080 4 . . . en-wikipedia-org-9224 1081 1 ^ ^ NNP en-wikipedia-org-9224 1081 2 Gerloni Gerloni NNP en-wikipedia-org-9224 1081 3 M M NNP en-wikipedia-org-9224 1081 4 , , , en-wikipedia-org-9224 1081 5 Zanetti Zanetti NNP en-wikipedia-org-9224 1081 6 M M NNP en-wikipedia-org-9224 1081 7 ( ( -LRB- en-wikipedia-org-9224 1081 8 June June NNP en-wikipedia-org-9224 1081 9 2005 2005 CD en-wikipedia-org-9224 1081 10 ) ) -RRB- en-wikipedia-org-9224 1081 11 . . . en-wikipedia-org-9224 1082 1 " " `` en-wikipedia-org-9224 1082 2 CD4 CD4 NNP en-wikipedia-org-9224 1082 3 T T NNP en-wikipedia-org-9224 1082 4 cells cell NNS en-wikipedia-org-9224 1082 5 in in IN en-wikipedia-org-9224 1082 6 tumor tumor NN en-wikipedia-org-9224 1082 7 immunity immunity NN en-wikipedia-org-9224 1082 8 " " '' en-wikipedia-org-9224 1082 9 . . . en-wikipedia-org-9224 1083 1 Springer Springer NNP en-wikipedia-org-9224 1083 2 Seminars Seminars NNPS en-wikipedia-org-9224 1083 3 in in IN en-wikipedia-org-9224 1083 4 Immunopathology Immunopathology NNP en-wikipedia-org-9224 1083 5 . . . en-wikipedia-org-9224 1084 1 27 27 CD en-wikipedia-org-9224 1084 2 ( ( -LRB- en-wikipedia-org-9224 1084 3 1 1 CD en-wikipedia-org-9224 1084 4 ) ) -RRB- en-wikipedia-org-9224 1084 5 : : : en-wikipedia-org-9224 1084 6 37–48 37–48 LS en-wikipedia-org-9224 1084 7 . . . en-wikipedia-org-9224 1085 1 doi:10.1007 doi:10.1007 NNP en-wikipedia-org-9224 1085 2 / / SYM en-wikipedia-org-9224 1085 3 s00281 s00281 NNP en-wikipedia-org-9224 1085 4 - - HYPH en-wikipedia-org-9224 1085 5 004 004 CD en-wikipedia-org-9224 1085 6 - - HYPH en-wikipedia-org-9224 1085 7 0193-z 0193-z NN en-wikipedia-org-9224 1085 8 . . . en-wikipedia-org-9224 1086 1 PMID PMID NNP en-wikipedia-org-9224 1086 2   _SP en-wikipedia-org-9224 1086 3 15965712 15965712 CD en-wikipedia-org-9224 1086 4 . . . en-wikipedia-org-9224 1087 1 S2CID S2CID NNS en-wikipedia-org-9224 1087 2   _SP en-wikipedia-org-9224 1087 3 25182066 25182066 CD en-wikipedia-org-9224 1087 4 . . . en-wikipedia-org-9224 1088 1 ^ ^ NNP en-wikipedia-org-9224 1088 2 a a DT en-wikipedia-org-9224 1088 3 b b NN en-wikipedia-org-9224 1088 4 Seliger Seliger NNP en-wikipedia-org-9224 1088 5 B B NNP en-wikipedia-org-9224 1088 6 , , , en-wikipedia-org-9224 1088 7 Ritz Ritz NNP en-wikipedia-org-9224 1088 8 U U NNP en-wikipedia-org-9224 1088 9 , , , en-wikipedia-org-9224 1088 10 Ferrone Ferrone NNP en-wikipedia-org-9224 1088 11 S S NNP en-wikipedia-org-9224 1088 12 ( ( -LRB- en-wikipedia-org-9224 1088 13 January January NNP en-wikipedia-org-9224 1088 14 2006 2006 CD en-wikipedia-org-9224 1088 15 ) ) -RRB- en-wikipedia-org-9224 1088 16 . . . en-wikipedia-org-9224 1089 1 " " `` en-wikipedia-org-9224 1089 2 Molecular molecular JJ en-wikipedia-org-9224 1089 3 mechanisms mechanism NNS en-wikipedia-org-9224 1089 4 of of IN en-wikipedia-org-9224 1089 5 HLA HLA NNP en-wikipedia-org-9224 1089 6 class class NN en-wikipedia-org-9224 1089 7 I -PRON- PRP en-wikipedia-org-9224 1089 8 antigen antigen VBP en-wikipedia-org-9224 1089 9 abnormalities abnormality NNS en-wikipedia-org-9224 1089 10 following follow VBG en-wikipedia-org-9224 1089 11 viral viral JJ en-wikipedia-org-9224 1089 12 infection infection NN en-wikipedia-org-9224 1089 13 and and CC en-wikipedia-org-9224 1089 14 transformation transformation NN en-wikipedia-org-9224 1089 15 " " '' en-wikipedia-org-9224 1089 16 . . . en-wikipedia-org-9224 1090 1 International International NNP en-wikipedia-org-9224 1090 2 Journal Journal NNP en-wikipedia-org-9224 1090 3 of of IN en-wikipedia-org-9224 1090 4 Cancer Cancer NNP en-wikipedia-org-9224 1090 5 . . . en-wikipedia-org-9224 1091 1 118 118 CD en-wikipedia-org-9224 1091 2 ( ( -LRB- en-wikipedia-org-9224 1091 3 1 1 CD en-wikipedia-org-9224 1091 4 ) ) -RRB- en-wikipedia-org-9224 1091 5 : : : en-wikipedia-org-9224 1091 6 129–38 129–38 CD en-wikipedia-org-9224 1091 7 . . . en-wikipedia-org-9224 1092 1 doi:10.1002 doi:10.1002 NNP en-wikipedia-org-9224 1092 2 / / SYM en-wikipedia-org-9224 1092 3 ijc.21312 ijc.21312 NNP en-wikipedia-org-9224 1092 4 . . . en-wikipedia-org-9224 1093 1 PMID PMID NNP en-wikipedia-org-9224 1093 2   _SP en-wikipedia-org-9224 1093 3 16003759 16003759 CD en-wikipedia-org-9224 1093 4 . . . en-wikipedia-org-9224 1094 1 S2CID S2CID NNS en-wikipedia-org-9224 1094 2   _SP en-wikipedia-org-9224 1094 3 5655726 5655726 CD en-wikipedia-org-9224 1094 4 . . . en-wikipedia-org-9224 1095 1 ^ ^ NNP en-wikipedia-org-9224 1095 2 Hayakawa Hayakawa NNP en-wikipedia-org-9224 1095 3 Y Y NNP en-wikipedia-org-9224 1095 4 , , , en-wikipedia-org-9224 1095 5 Smyth Smyth NNP en-wikipedia-org-9224 1095 6 MJ MJ NNP en-wikipedia-org-9224 1095 7 ( ( -LRB- en-wikipedia-org-9224 1095 8 2006 2006 CD en-wikipedia-org-9224 1095 9 ) ) -RRB- en-wikipedia-org-9224 1095 10 . . . en-wikipedia-org-9224 1096 1 " " `` en-wikipedia-org-9224 1096 2 Innate innate VB en-wikipedia-org-9224 1096 3 immune immune JJ en-wikipedia-org-9224 1096 4 recognition recognition NN en-wikipedia-org-9224 1096 5 and and CC en-wikipedia-org-9224 1096 6 suppression suppression NN en-wikipedia-org-9224 1096 7 of of IN en-wikipedia-org-9224 1096 8 tumors tumor NNS en-wikipedia-org-9224 1096 9 " " '' en-wikipedia-org-9224 1096 10 . . . en-wikipedia-org-9224 1097 1 Advances advance NNS en-wikipedia-org-9224 1097 2 in in IN en-wikipedia-org-9224 1097 3 Cancer Cancer NNP en-wikipedia-org-9224 1097 4 Research Research NNP en-wikipedia-org-9224 1097 5 . . . en-wikipedia-org-9224 1098 1 95 95 CD en-wikipedia-org-9224 1098 2 : : : en-wikipedia-org-9224 1098 3 293–322 293–322 CD en-wikipedia-org-9224 1098 4 . . . en-wikipedia-org-9224 1099 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 1099 2 / / SYM en-wikipedia-org-9224 1099 3 S0065 S0065 NNP en-wikipedia-org-9224 1099 4 - - HYPH en-wikipedia-org-9224 1099 5 230X(06)95008 230X(06)95008 NNP en-wikipedia-org-9224 1099 6 - - HYPH en-wikipedia-org-9224 1099 7 8 8 CD en-wikipedia-org-9224 1099 8 . . . en-wikipedia-org-9224 1100 1 ISBN ISBN NNP en-wikipedia-org-9224 1100 2   _SP en-wikipedia-org-9224 1100 3 978 978 CD en-wikipedia-org-9224 1100 4 - - HYPH en-wikipedia-org-9224 1100 5 0 0 CD en-wikipedia-org-9224 1100 6 - - HYPH en-wikipedia-org-9224 1100 7 12 12 CD en-wikipedia-org-9224 1100 8 - - HYPH en-wikipedia-org-9224 1100 9 006695 006695 CD en-wikipedia-org-9224 1100 10 - - HYPH en-wikipedia-org-9224 1100 11 7 7 CD en-wikipedia-org-9224 1100 12 . . . en-wikipedia-org-9224 1101 1 PMID PMID NNP en-wikipedia-org-9224 1101 2   _SP en-wikipedia-org-9224 1101 3 16860661 16860661 CD en-wikipedia-org-9224 1101 4 . . . en-wikipedia-org-9224 1102 1 ^ ^ NNP en-wikipedia-org-9224 1102 2 a a DT en-wikipedia-org-9224 1102 3 b b NNP en-wikipedia-org-9224 1102 4 c c NNP en-wikipedia-org-9224 1102 5 d d NN en-wikipedia-org-9224 1102 6 e e NNP en-wikipedia-org-9224 1102 7 f f NNP en-wikipedia-org-9224 1102 8 Syn Syn NNP en-wikipedia-org-9224 1102 9 NL NL NNP en-wikipedia-org-9224 1102 10 , , , en-wikipedia-org-9224 1102 11 Teng Teng NNP en-wikipedia-org-9224 1102 12 MW MW NNP en-wikipedia-org-9224 1102 13 , , , en-wikipedia-org-9224 1102 14 Mok Mok NNP en-wikipedia-org-9224 1102 15 TS TS NNP en-wikipedia-org-9224 1102 16 , , , en-wikipedia-org-9224 1102 17 Soo Soo NNP en-wikipedia-org-9224 1102 18 RA RA NNP en-wikipedia-org-9224 1102 19 ( ( -LRB- en-wikipedia-org-9224 1102 20 December December NNP en-wikipedia-org-9224 1102 21 2017 2017 CD en-wikipedia-org-9224 1102 22 ) ) -RRB- en-wikipedia-org-9224 1102 23 . . . en-wikipedia-org-9224 1103 1 " " `` en-wikipedia-org-9224 1103 2 De De NNP en-wikipedia-org-9224 1103 3 - - HYPH en-wikipedia-org-9224 1103 4 novo novo NNP en-wikipedia-org-9224 1103 5 and and CC en-wikipedia-org-9224 1103 6 acquired acquire VBD en-wikipedia-org-9224 1103 7 resistance resistance NN en-wikipedia-org-9224 1103 8 to to IN en-wikipedia-org-9224 1103 9 immune immune JJ en-wikipedia-org-9224 1103 10 checkpoint checkpoint NN en-wikipedia-org-9224 1103 11 targeting targeting NN en-wikipedia-org-9224 1103 12 " " '' en-wikipedia-org-9224 1103 13 . . . en-wikipedia-org-9224 1104 1 The the DT en-wikipedia-org-9224 1104 2 Lancet Lancet NNP en-wikipedia-org-9224 1104 3 . . . en-wikipedia-org-9224 1105 1 Oncology oncology NN en-wikipedia-org-9224 1105 2 . . . en-wikipedia-org-9224 1106 1 18 18 CD en-wikipedia-org-9224 1106 2 ( ( -LRB- en-wikipedia-org-9224 1106 3 12 12 CD en-wikipedia-org-9224 1106 4 ) ) -RRB- en-wikipedia-org-9224 1106 5 : : : en-wikipedia-org-9224 1106 6 e731–e741 e731–e741 NNP en-wikipedia-org-9224 1106 7 . . . en-wikipedia-org-9224 1107 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 1107 2 / / SYM en-wikipedia-org-9224 1107 3 s1470 s1470 JJ en-wikipedia-org-9224 1107 4 - - HYPH en-wikipedia-org-9224 1107 5 2045(17)30607 2045(17)30607 CD en-wikipedia-org-9224 1107 6 - - HYPH en-wikipedia-org-9224 1107 7 1 1 CD en-wikipedia-org-9224 1107 8 . . . en-wikipedia-org-9224 1108 1 PMID PMID NNP en-wikipedia-org-9224 1108 2   _SP en-wikipedia-org-9224 1108 3 29208439 29208439 CD en-wikipedia-org-9224 1108 4 . . . en-wikipedia-org-9224 1109 1 ^ ^ NNP en-wikipedia-org-9224 1109 2 a a DT en-wikipedia-org-9224 1109 3 b b NN en-wikipedia-org-9224 1109 4 Seliger Seliger NNP en-wikipedia-org-9224 1109 5 B B NNP en-wikipedia-org-9224 1109 6 ( ( -LRB- en-wikipedia-org-9224 1109 7 2005 2005 CD en-wikipedia-org-9224 1109 8 ) ) -RRB- en-wikipedia-org-9224 1109 9 . . . en-wikipedia-org-9224 1110 1 " " `` en-wikipedia-org-9224 1110 2 Strategies strategy NNS en-wikipedia-org-9224 1110 3 of of IN en-wikipedia-org-9224 1110 4 tumor tumor NN en-wikipedia-org-9224 1110 5 immune immune JJ en-wikipedia-org-9224 1110 6 evasion evasion NN en-wikipedia-org-9224 1110 7 " " '' en-wikipedia-org-9224 1110 8 . . . en-wikipedia-org-9224 1111 1 BioDrugs biodrug NNS en-wikipedia-org-9224 1111 2 . . . en-wikipedia-org-9224 1112 1 19 19 CD en-wikipedia-org-9224 1112 2 ( ( -LRB- en-wikipedia-org-9224 1112 3 6 6 CD en-wikipedia-org-9224 1112 4 ) ) -RRB- en-wikipedia-org-9224 1112 5 : : : en-wikipedia-org-9224 1112 6 347–54 347–54 CD en-wikipedia-org-9224 1112 7 . . . en-wikipedia-org-9224 1113 1 doi:10.2165/00063030 doi:10.2165/00063030 JJ en-wikipedia-org-9224 1113 2 - - HYPH en-wikipedia-org-9224 1113 3 200519060 200519060 CD en-wikipedia-org-9224 1113 4 - - HYPH en-wikipedia-org-9224 1113 5 00002 00002 CD en-wikipedia-org-9224 1113 6 . . . en-wikipedia-org-9224 1114 1 PMID PMID NNP en-wikipedia-org-9224 1114 2   _SP en-wikipedia-org-9224 1114 3 16392887 16392887 CD en-wikipedia-org-9224 1114 4 . . . en-wikipedia-org-9224 1115 1 S2CID S2CID NNP en-wikipedia-org-9224 1115 2   _SP en-wikipedia-org-9224 1115 3 1838144 1838144 CD en-wikipedia-org-9224 1115 4 . . . en-wikipedia-org-9224 1116 1 ^ ^ NN en-wikipedia-org-9224 1116 2 Frumento frumento IN en-wikipedia-org-9224 1116 3 G G NNP en-wikipedia-org-9224 1116 4 , , , en-wikipedia-org-9224 1116 5 Piazza Piazza NNP en-wikipedia-org-9224 1116 6 T T NNP en-wikipedia-org-9224 1116 7 , , , en-wikipedia-org-9224 1116 8 Di Di NNP en-wikipedia-org-9224 1116 9 Carlo Carlo NNP en-wikipedia-org-9224 1116 10 E E NNP en-wikipedia-org-9224 1116 11 , , , en-wikipedia-org-9224 1116 12 Ferrini Ferrini NNP en-wikipedia-org-9224 1116 13 S S NNP en-wikipedia-org-9224 1116 14 ( ( -LRB- en-wikipedia-org-9224 1116 15 September September NNP en-wikipedia-org-9224 1116 16 2006 2006 CD en-wikipedia-org-9224 1116 17 ) ) -RRB- en-wikipedia-org-9224 1116 18 . . . en-wikipedia-org-9224 1117 1 " " `` en-wikipedia-org-9224 1117 2 Targeting target VBG en-wikipedia-org-9224 1117 3 tumor tumor NN en-wikipedia-org-9224 1117 4 - - HYPH en-wikipedia-org-9224 1117 5 related relate VBN en-wikipedia-org-9224 1117 6 immunosuppression immunosuppression NN en-wikipedia-org-9224 1117 7 for for IN en-wikipedia-org-9224 1117 8 cancer cancer NN en-wikipedia-org-9224 1117 9 immunotherapy immunotherapy NN en-wikipedia-org-9224 1117 10 " " '' en-wikipedia-org-9224 1117 11 . . . en-wikipedia-org-9224 1118 1 Endocrine endocrine VB en-wikipedia-org-9224 1118 2 , , , en-wikipedia-org-9224 1118 3 Metabolic Metabolic NNP en-wikipedia-org-9224 1118 4 & & CC en-wikipedia-org-9224 1118 5 Immune Immune NNP en-wikipedia-org-9224 1118 6 Disorders Disorders NNPS en-wikipedia-org-9224 1118 7 Drug Drug NNP en-wikipedia-org-9224 1118 8 Targets Targets NNPS en-wikipedia-org-9224 1118 9 . . . en-wikipedia-org-9224 1119 1 6 6 CD en-wikipedia-org-9224 1119 2 ( ( -LRB- en-wikipedia-org-9224 1119 3 3 3 CD en-wikipedia-org-9224 1119 4 ) ) -RRB- en-wikipedia-org-9224 1119 5 : : : en-wikipedia-org-9224 1119 6 233–7 233–7 CD en-wikipedia-org-9224 1119 7 . . . en-wikipedia-org-9224 1120 1 doi:10.2174/187153006778250019 doi:10.2174/187153006778250019 NN en-wikipedia-org-9224 1120 2 . . . en-wikipedia-org-9224 1121 1 PMID PMID NNP en-wikipedia-org-9224 1121 2   _SP en-wikipedia-org-9224 1121 3 17017974 17017974 CD en-wikipedia-org-9224 1121 4 . . . en-wikipedia-org-9224 1122 1 ^ ^ NFP en-wikipedia-org-9224 1122 2 Stix Stix NNP en-wikipedia-org-9224 1122 3 G G NNP en-wikipedia-org-9224 1122 4 ( ( -LRB- en-wikipedia-org-9224 1122 5 July July NNP en-wikipedia-org-9224 1122 6 2007 2007 CD en-wikipedia-org-9224 1122 7 ) ) -RRB- en-wikipedia-org-9224 1122 8 . . . en-wikipedia-org-9224 1123 1 " " `` en-wikipedia-org-9224 1123 2 A a DT en-wikipedia-org-9224 1123 3 malignant malignant JJ en-wikipedia-org-9224 1123 4 flame flame NN en-wikipedia-org-9224 1123 5 . . . en-wikipedia-org-9224 1124 1 Understanding understand VBG en-wikipedia-org-9224 1124 2 chronic chronic JJ en-wikipedia-org-9224 1124 3 inflammation inflammation NN en-wikipedia-org-9224 1124 4 , , , en-wikipedia-org-9224 1124 5 which which WDT en-wikipedia-org-9224 1124 6 contributes contribute VBZ en-wikipedia-org-9224 1124 7 to to IN en-wikipedia-org-9224 1124 8 heart heart NN en-wikipedia-org-9224 1124 9 disease disease NN en-wikipedia-org-9224 1124 10 , , , en-wikipedia-org-9224 1124 11 Alzheimer Alzheimer NNP en-wikipedia-org-9224 1124 12 's 's POS en-wikipedia-org-9224 1124 13 and and CC en-wikipedia-org-9224 1124 14 a a DT en-wikipedia-org-9224 1124 15 variety variety NN en-wikipedia-org-9224 1124 16 of of IN en-wikipedia-org-9224 1124 17 other other JJ en-wikipedia-org-9224 1124 18 ailments ailment NNS en-wikipedia-org-9224 1124 19 , , , en-wikipedia-org-9224 1124 20 may may MD en-wikipedia-org-9224 1124 21 be be VB en-wikipedia-org-9224 1124 22 a a DT en-wikipedia-org-9224 1124 23 key key NN en-wikipedia-org-9224 1124 24 to to IN en-wikipedia-org-9224 1124 25 unlocking unlock VBG en-wikipedia-org-9224 1124 26 the the DT en-wikipedia-org-9224 1124 27 mysteries mystery NNS en-wikipedia-org-9224 1124 28 of of IN en-wikipedia-org-9224 1124 29 cancer cancer NN en-wikipedia-org-9224 1124 30 " " '' en-wikipedia-org-9224 1124 31 ( ( -LRB- en-wikipedia-org-9224 1124 32 PDF PDF NNP en-wikipedia-org-9224 1124 33 ) ) -RRB- en-wikipedia-org-9224 1124 34 . . . en-wikipedia-org-9224 1125 1 Scientific scientific JJ en-wikipedia-org-9224 1125 2 American American NNP en-wikipedia-org-9224 1125 3 . . . en-wikipedia-org-9224 1126 1 297 297 CD en-wikipedia-org-9224 1126 2 ( ( -LRB- en-wikipedia-org-9224 1126 3 1 1 CD en-wikipedia-org-9224 1126 4 ) ) -RRB- en-wikipedia-org-9224 1126 5 : : : en-wikipedia-org-9224 1126 6 60–67 60–67 CD en-wikipedia-org-9224 1126 7 . . . en-wikipedia-org-9224 1127 1 Bibcode:2007SciAm.297a bibcode:2007sciam.297a NN en-wikipedia-org-9224 1127 2 .. .. . en-wikipedia-org-9224 1127 3 60S. 60s. LS en-wikipedia-org-9224 1128 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 1128 2 / / SYM en-wikipedia-org-9224 1128 3 scientificamerican0707 scientificamerican0707 NNP en-wikipedia-org-9224 1128 4 - - HYPH en-wikipedia-org-9224 1128 5 60 60 NNP en-wikipedia-org-9224 1128 6 . . . en-wikipedia-org-9224 1129 1 PMID PMID NNP en-wikipedia-org-9224 1129 2   _SP en-wikipedia-org-9224 1129 3 17695843 17695843 CD en-wikipedia-org-9224 1129 4 . . . en-wikipedia-org-9224 1130 1 Archived archived JJ en-wikipedia-org-9224 1130 2 from from IN en-wikipedia-org-9224 1130 3 the the DT en-wikipedia-org-9224 1130 4 original original JJ en-wikipedia-org-9224 1130 5 ( ( -LRB- en-wikipedia-org-9224 1130 6 PDF PDF NNP en-wikipedia-org-9224 1130 7 ) ) -RRB- en-wikipedia-org-9224 1130 8 on on IN en-wikipedia-org-9224 1130 9 16 16 CD en-wikipedia-org-9224 1130 10 July July NNP en-wikipedia-org-9224 1130 11 2011 2011 CD en-wikipedia-org-9224 1130 12 . . . en-wikipedia-org-9224 1131 1 ^ ^ NNP en-wikipedia-org-9224 1131 2 Cervantes Cervantes NNP en-wikipedia-org-9224 1131 3 - - HYPH en-wikipedia-org-9224 1131 4 Villagrana Villagrana NNP en-wikipedia-org-9224 1131 5 RD RD NNP en-wikipedia-org-9224 1131 6 , , , en-wikipedia-org-9224 1131 7 Albores Albores NNP en-wikipedia-org-9224 1131 8 - - HYPH en-wikipedia-org-9224 1131 9 García García NNP en-wikipedia-org-9224 1131 10 D D NNP en-wikipedia-org-9224 1131 11 , , , en-wikipedia-org-9224 1131 12 Cervantes Cervantes NNP en-wikipedia-org-9224 1131 13 - - HYPH en-wikipedia-org-9224 1131 14 Villagrana Villagrana NNP en-wikipedia-org-9224 1131 15 AR AR NNP en-wikipedia-org-9224 1131 16 , , , en-wikipedia-org-9224 1131 17 García García NNP en-wikipedia-org-9224 1131 18 - - HYPH en-wikipedia-org-9224 1131 19 Acevez Acevez NNP en-wikipedia-org-9224 1131 20 SJ SJ NNP en-wikipedia-org-9224 1131 21 ( ( -LRB- en-wikipedia-org-9224 1131 22 18 18 CD en-wikipedia-org-9224 1131 23 June June NNP en-wikipedia-org-9224 1131 24 2020 2020 CD en-wikipedia-org-9224 1131 25 ) ) -RRB- en-wikipedia-org-9224 1131 26 . . . en-wikipedia-org-9224 1132 1 " " `` en-wikipedia-org-9224 1132 2 Tumor tumor NN en-wikipedia-org-9224 1132 3 - - HYPH en-wikipedia-org-9224 1132 4 induced induce VBN en-wikipedia-org-9224 1132 5 Neurogenesis Neurogenesis NNP en-wikipedia-org-9224 1132 6 and and CC en-wikipedia-org-9224 1132 7 Immune Immune NNP en-wikipedia-org-9224 1132 8 Evasion Evasion NNP en-wikipedia-org-9224 1132 9 as as IN en-wikipedia-org-9224 1132 10 Targets target NNS en-wikipedia-org-9224 1132 11 of of IN en-wikipedia-org-9224 1132 12 Innovative innovative JJ en-wikipedia-org-9224 1132 13 Anti Anti NNP en-wikipedia-org-9224 1132 14 - - NNP en-wikipedia-org-9224 1132 15 Cancer Cancer NNP en-wikipedia-org-9224 1132 16 Therapies Therapies NNPS en-wikipedia-org-9224 1132 17 " " '' en-wikipedia-org-9224 1132 18 . . . en-wikipedia-org-9224 1133 1 Signal Signal NNP en-wikipedia-org-9224 1133 2 Transduct Transduct NNP en-wikipedia-org-9224 1133 3 Target Target NNP en-wikipedia-org-9224 1133 4 Ther Ther NNP en-wikipedia-org-9224 1133 5 . . . en-wikipedia-org-9224 1134 1 5 5 CD en-wikipedia-org-9224 1134 2 ( ( -LRB- en-wikipedia-org-9224 1134 3 1 1 CD en-wikipedia-org-9224 1134 4 ) ) -RRB- en-wikipedia-org-9224 1134 5 : : : en-wikipedia-org-9224 1134 6 99 99 CD en-wikipedia-org-9224 1134 7 . . . en-wikipedia-org-9224 1134 8 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 1134 9 / / SYM en-wikipedia-org-9224 1134 10 s41392 s41392 NNP en-wikipedia-org-9224 1134 11 - - HYPH en-wikipedia-org-9224 1134 12 020 020 NNP en-wikipedia-org-9224 1134 13 - - HYPH en-wikipedia-org-9224 1134 14 0205-z 0205-z NN en-wikipedia-org-9224 1134 15 . . . en-wikipedia-org-9224 1135 1 PMC PMC NNP en-wikipedia-org-9224 1135 2   _SP en-wikipedia-org-9224 1135 3 7303203 7303203 CD en-wikipedia-org-9224 1135 4 . . . en-wikipedia-org-9224 1136 1 PMID PMID NNP en-wikipedia-org-9224 1136 2   _SP en-wikipedia-org-9224 1136 3 32555170 32555170 CD en-wikipedia-org-9224 1136 4 . . . en-wikipedia-org-9224 1137 1 ^ ^ NN en-wikipedia-org-9224 1137 2 Yang Yang NNP en-wikipedia-org-9224 1137 3 Y Y NNP en-wikipedia-org-9224 1137 4 ( ( -LRB- en-wikipedia-org-9224 1137 5 September September NNP en-wikipedia-org-9224 1137 6 2015 2015 CD en-wikipedia-org-9224 1137 7 ) ) -RRB- en-wikipedia-org-9224 1137 8 . . . en-wikipedia-org-9224 1138 1 " " `` en-wikipedia-org-9224 1138 2 Cancer cancer NN en-wikipedia-org-9224 1138 3 immunotherapy immunotherapy NN en-wikipedia-org-9224 1138 4 : : : en-wikipedia-org-9224 1138 5 harnessing harness VBG en-wikipedia-org-9224 1138 6 the the DT en-wikipedia-org-9224 1138 7 immune immune JJ en-wikipedia-org-9224 1138 8 system system NN en-wikipedia-org-9224 1138 9 to to IN en-wikipedia-org-9224 1138 10 battle battle NN en-wikipedia-org-9224 1138 11 cancer cancer NN en-wikipedia-org-9224 1138 12 " " '' en-wikipedia-org-9224 1138 13 . . . en-wikipedia-org-9224 1139 1 The the DT en-wikipedia-org-9224 1139 2 Journal Journal NNP en-wikipedia-org-9224 1139 3 of of IN en-wikipedia-org-9224 1139 4 Clinical Clinical NNP en-wikipedia-org-9224 1139 5 Investigation Investigation NNP en-wikipedia-org-9224 1139 6 . . . en-wikipedia-org-9224 1140 1 125 125 CD en-wikipedia-org-9224 1140 2 ( ( -LRB- en-wikipedia-org-9224 1140 3 9 9 CD en-wikipedia-org-9224 1140 4 ) ) -RRB- en-wikipedia-org-9224 1140 5 : : : en-wikipedia-org-9224 1140 6 3335–7 3335–7 CD en-wikipedia-org-9224 1140 7 . . . en-wikipedia-org-9224 1141 1 doi:10.1172 doi:10.1172 NNP en-wikipedia-org-9224 1141 2 / / SYM en-wikipedia-org-9224 1141 3 JCI83871 JCI83871 NNP en-wikipedia-org-9224 1141 4 . . . en-wikipedia-org-9224 1142 1 PMC PMC NNP en-wikipedia-org-9224 1142 2   _SP en-wikipedia-org-9224 1142 3 4588312 4588312 CD en-wikipedia-org-9224 1142 4 . . . en-wikipedia-org-9224 1143 1 PMID PMID NNP en-wikipedia-org-9224 1143 2   _SP en-wikipedia-org-9224 1143 3 26325031 26325031 CD en-wikipedia-org-9224 1143 4 . . . en-wikipedia-org-9224 1144 1 ^ ^ NNP en-wikipedia-org-9224 1144 2 Baker Baker NNP en-wikipedia-org-9224 1144 3 MP MP NNP en-wikipedia-org-9224 1144 4 , , , en-wikipedia-org-9224 1144 5 Reynolds Reynolds NNP en-wikipedia-org-9224 1144 6 HM HM NNP en-wikipedia-org-9224 1144 7 , , , en-wikipedia-org-9224 1144 8 Lumicisi Lumicisi NNP en-wikipedia-org-9224 1144 9 B B NNP en-wikipedia-org-9224 1144 10 , , , en-wikipedia-org-9224 1144 11 Bryson Bryson NNP en-wikipedia-org-9224 1144 12 CJ CJ NNP en-wikipedia-org-9224 1144 13 ( ( -LRB- en-wikipedia-org-9224 1144 14 October October NNP en-wikipedia-org-9224 1144 15 2010 2010 CD en-wikipedia-org-9224 1144 16 ) ) -RRB- en-wikipedia-org-9224 1144 17 . . . en-wikipedia-org-9224 1145 1 " " `` en-wikipedia-org-9224 1145 2 Immunogenicity immunogenicity NN en-wikipedia-org-9224 1145 3 of of IN en-wikipedia-org-9224 1145 4 protein protein NN en-wikipedia-org-9224 1145 5 therapeutics therapeutic NNS en-wikipedia-org-9224 1145 6 : : : en-wikipedia-org-9224 1145 7 The the DT en-wikipedia-org-9224 1145 8 key key JJ en-wikipedia-org-9224 1145 9 causes cause NNS en-wikipedia-org-9224 1145 10 , , , en-wikipedia-org-9224 1145 11 consequences consequence NNS en-wikipedia-org-9224 1145 12 and and CC en-wikipedia-org-9224 1145 13 challenges challenge NNS en-wikipedia-org-9224 1145 14 " " '' en-wikipedia-org-9224 1145 15 . . . en-wikipedia-org-9224 1146 1 Self self NN en-wikipedia-org-9224 1146 2 / / SYM en-wikipedia-org-9224 1146 3 Nonself Nonself NNP en-wikipedia-org-9224 1146 4 . . . en-wikipedia-org-9224 1147 1 1 1 CD en-wikipedia-org-9224 1147 2 ( ( -LRB- en-wikipedia-org-9224 1147 3 4 4 CD en-wikipedia-org-9224 1147 4 ) ) -RRB- en-wikipedia-org-9224 1147 5 : : : en-wikipedia-org-9224 1147 6 314–322 314–322 CD en-wikipedia-org-9224 1147 7 . . . en-wikipedia-org-9224 1148 1 doi:10.4161 doi:10.4161 NNP en-wikipedia-org-9224 1148 2 / / SYM en-wikipedia-org-9224 1148 3 self.1.4.13904 self.1.4.13904 NNP en-wikipedia-org-9224 1148 4 . . . en-wikipedia-org-9224 1149 1 PMC PMC NNP en-wikipedia-org-9224 1149 2   _SP en-wikipedia-org-9224 1149 3 3062386 3062386 CD en-wikipedia-org-9224 1149 4 . . . en-wikipedia-org-9224 1150 1 PMID PMID NNP en-wikipedia-org-9224 1150 2   _SP en-wikipedia-org-9224 1150 3 21487506 21487506 CD en-wikipedia-org-9224 1150 4 . . . en-wikipedia-org-9224 1151 1 ^ ^ NNP en-wikipedia-org-9224 1151 2 Welling Welling NNP en-wikipedia-org-9224 1151 3 GW GW NNP en-wikipedia-org-9224 1151 4 , , , en-wikipedia-org-9224 1151 5 Weijer Weijer NNP en-wikipedia-org-9224 1151 6 WJ WJ NNP en-wikipedia-org-9224 1151 7 , , , en-wikipedia-org-9224 1151 8 van van NNP en-wikipedia-org-9224 1151 9 der der NNP en-wikipedia-org-9224 1151 10 Zee Zee NNP en-wikipedia-org-9224 1151 11 R r NN en-wikipedia-org-9224 1151 12 , , , en-wikipedia-org-9224 1151 13 Welling Welling NNP en-wikipedia-org-9224 1151 14 - - HYPH en-wikipedia-org-9224 1151 15 Wester Wester NNP en-wikipedia-org-9224 1151 16 S S NNP en-wikipedia-org-9224 1151 17 ( ( -LRB- en-wikipedia-org-9224 1151 18 September September NNP en-wikipedia-org-9224 1151 19 1985 1985 CD en-wikipedia-org-9224 1151 20 ) ) -RRB- en-wikipedia-org-9224 1151 21 . . . en-wikipedia-org-9224 1152 1 " " `` en-wikipedia-org-9224 1152 2 Prediction prediction NN en-wikipedia-org-9224 1152 3 of of IN en-wikipedia-org-9224 1152 4 sequential sequential JJ en-wikipedia-org-9224 1152 5 antigenic antigenic JJ en-wikipedia-org-9224 1152 6 regions region NNS en-wikipedia-org-9224 1152 7 in in IN en-wikipedia-org-9224 1152 8 proteins protein NNS en-wikipedia-org-9224 1152 9 " " '' en-wikipedia-org-9224 1152 10 . . . en-wikipedia-org-9224 1153 1 FEBS FEBS NNP en-wikipedia-org-9224 1153 2 Letters Letters NNPS en-wikipedia-org-9224 1153 3 . . . en-wikipedia-org-9224 1154 1 188 188 CD en-wikipedia-org-9224 1154 2 ( ( -LRB- en-wikipedia-org-9224 1154 3 2 2 CD en-wikipedia-org-9224 1154 4 ) ) -RRB- en-wikipedia-org-9224 1154 5 : : : en-wikipedia-org-9224 1154 6 215–18 215–18 CD en-wikipedia-org-9224 1154 7 . . . en-wikipedia-org-9224 1155 1 doi:10.1016/0014 doi:10.1016/0014 NNS en-wikipedia-org-9224 1155 2 - - HYPH en-wikipedia-org-9224 1155 3 5793(85)80374 5793(85)80374 NNP en-wikipedia-org-9224 1155 4 - - HYPH en-wikipedia-org-9224 1155 5 4 4 CD en-wikipedia-org-9224 1155 6 . . . en-wikipedia-org-9224 1156 1 PMID PMID NNP en-wikipedia-org-9224 1156 2   _SP en-wikipedia-org-9224 1156 3 2411595 2411595 CD en-wikipedia-org-9224 1156 4 . . . en-wikipedia-org-9224 1157 1 ^ ^ NNP en-wikipedia-org-9224 1157 2 Söllner Söllner NNP en-wikipedia-org-9224 1157 3 J J NNP en-wikipedia-org-9224 1157 4 , , , en-wikipedia-org-9224 1157 5 Mayer Mayer NNP en-wikipedia-org-9224 1157 6 B B NNP en-wikipedia-org-9224 1157 7 ( ( -LRB- en-wikipedia-org-9224 1157 8 2006 2006 CD en-wikipedia-org-9224 1157 9 ) ) -RRB- en-wikipedia-org-9224 1157 10 . . . en-wikipedia-org-9224 1158 1 " " `` en-wikipedia-org-9224 1158 2 Machine machine NN en-wikipedia-org-9224 1158 3 learning learning NN en-wikipedia-org-9224 1158 4 approaches approach NNS en-wikipedia-org-9224 1158 5 for for IN en-wikipedia-org-9224 1158 6 prediction prediction NN en-wikipedia-org-9224 1158 7 of of IN en-wikipedia-org-9224 1158 8 linear linear JJ en-wikipedia-org-9224 1158 9 B b NN en-wikipedia-org-9224 1158 10 - - HYPH en-wikipedia-org-9224 1158 11 cell cell NN en-wikipedia-org-9224 1158 12 epitopes epitope NNS en-wikipedia-org-9224 1158 13 on on IN en-wikipedia-org-9224 1158 14 proteins protein NNS en-wikipedia-org-9224 1158 15 " " '' en-wikipedia-org-9224 1158 16 . . . en-wikipedia-org-9224 1159 1 Journal Journal NNP en-wikipedia-org-9224 1159 2 of of IN en-wikipedia-org-9224 1159 3 Molecular Molecular NNP en-wikipedia-org-9224 1159 4 Recognition Recognition NNP en-wikipedia-org-9224 1159 5 . . . en-wikipedia-org-9224 1160 1 19 19 CD en-wikipedia-org-9224 1160 2 ( ( -LRB- en-wikipedia-org-9224 1160 3 3 3 CD en-wikipedia-org-9224 1160 4 ) ) -RRB- en-wikipedia-org-9224 1160 5 : : : en-wikipedia-org-9224 1160 6 200–08 200–08 CD en-wikipedia-org-9224 1160 7 . . . en-wikipedia-org-9224 1161 1 doi:10.1002 doi:10.1002 NNP en-wikipedia-org-9224 1161 2 / / SYM en-wikipedia-org-9224 1161 3 jmr.771 jmr.771 NN en-wikipedia-org-9224 1161 4 . . . en-wikipedia-org-9224 1162 1 PMID PMID NNP en-wikipedia-org-9224 1162 2   _SP en-wikipedia-org-9224 1162 3 16598694 16598694 CD en-wikipedia-org-9224 1162 4 . . . en-wikipedia-org-9224 1163 1 S2CID S2CID NNS en-wikipedia-org-9224 1163 2   _SP en-wikipedia-org-9224 1163 3 18197810 18197810 CD en-wikipedia-org-9224 1163 4 . . . en-wikipedia-org-9224 1164 1 ^ ^ NNP en-wikipedia-org-9224 1164 2 Saha Saha NNP en-wikipedia-org-9224 1164 3 S S NNP en-wikipedia-org-9224 1164 4 , , , en-wikipedia-org-9224 1164 5 Bhasin Bhasin NNP en-wikipedia-org-9224 1164 6 M M NNP en-wikipedia-org-9224 1164 7 , , , en-wikipedia-org-9224 1164 8 Raghava Raghava NNP en-wikipedia-org-9224 1164 9 GP GP NNP en-wikipedia-org-9224 1164 10 ( ( -LRB- en-wikipedia-org-9224 1164 11 2005 2005 CD en-wikipedia-org-9224 1164 12 ) ) -RRB- en-wikipedia-org-9224 1164 13 . . . en-wikipedia-org-9224 1165 1 " " `` en-wikipedia-org-9224 1165 2 Bcipep bcipep NN en-wikipedia-org-9224 1165 3 : : : en-wikipedia-org-9224 1165 4 a a DT en-wikipedia-org-9224 1165 5 database database NN en-wikipedia-org-9224 1165 6 of of IN en-wikipedia-org-9224 1165 7 B b NN en-wikipedia-org-9224 1165 8 - - HYPH en-wikipedia-org-9224 1165 9 cell cell NN en-wikipedia-org-9224 1165 10 epitopes epitope NNS en-wikipedia-org-9224 1165 11 " " '' en-wikipedia-org-9224 1165 12 . . . en-wikipedia-org-9224 1166 1 BMC BMC NNP en-wikipedia-org-9224 1166 2 Genomics Genomics NNP en-wikipedia-org-9224 1166 3 . . . en-wikipedia-org-9224 1167 1 6 6 CD en-wikipedia-org-9224 1167 2 : : SYM en-wikipedia-org-9224 1167 3 79 79 CD en-wikipedia-org-9224 1167 4 . . . en-wikipedia-org-9224 1167 5 doi:10.1186/1471 doi:10.1186/1471 NN en-wikipedia-org-9224 1167 6 - - HYPH en-wikipedia-org-9224 1167 7 2164 2164 CD en-wikipedia-org-9224 1167 8 - - HYPH en-wikipedia-org-9224 1167 9 6 6 CD en-wikipedia-org-9224 1167 10 - - HYPH en-wikipedia-org-9224 1167 11 79 79 CD en-wikipedia-org-9224 1167 12 . . . en-wikipedia-org-9224 1168 1 PMC PMC NNP en-wikipedia-org-9224 1168 2   _SP en-wikipedia-org-9224 1168 3 1173103 1173103 CD en-wikipedia-org-9224 1168 4 . . . en-wikipedia-org-9224 1169 1 PMID PMID NNP en-wikipedia-org-9224 1169 2   _SP en-wikipedia-org-9224 1169 3 15921533 15921533 CD en-wikipedia-org-9224 1169 4 . . . en-wikipedia-org-9224 1170 1 ^ ^ NNP en-wikipedia-org-9224 1170 2 Flower Flower NNP en-wikipedia-org-9224 1170 3 DR DR NNP en-wikipedia-org-9224 1170 4 , , , en-wikipedia-org-9224 1170 5 Doytchinova Doytchinova NNP en-wikipedia-org-9224 1170 6 IA IA NNP en-wikipedia-org-9224 1170 7 ( ( -LRB- en-wikipedia-org-9224 1170 8 2002 2002 CD en-wikipedia-org-9224 1170 9 ) ) -RRB- en-wikipedia-org-9224 1170 10 . . . en-wikipedia-org-9224 1171 1 " " `` en-wikipedia-org-9224 1171 2 Immunoinformatics immunoinformatic NNS en-wikipedia-org-9224 1171 3 and and CC en-wikipedia-org-9224 1171 4 the the DT en-wikipedia-org-9224 1171 5 prediction prediction NN en-wikipedia-org-9224 1171 6 of of IN en-wikipedia-org-9224 1171 7 immunogenicity immunogenicity NN en-wikipedia-org-9224 1171 8 " " '' en-wikipedia-org-9224 1171 9 . . . en-wikipedia-org-9224 1172 1 Applied Applied NNP en-wikipedia-org-9224 1172 2 Bioinformatics Bioinformatics NNP en-wikipedia-org-9224 1172 3 . . . en-wikipedia-org-9224 1173 1 1 1 CD en-wikipedia-org-9224 1173 2 ( ( -LRB- en-wikipedia-org-9224 1173 3 4 4 CD en-wikipedia-org-9224 1173 4 ) ) -RRB- en-wikipedia-org-9224 1173 5 : : : en-wikipedia-org-9224 1173 6 167–76 167–76 CD en-wikipedia-org-9224 1173 7 . . . en-wikipedia-org-9224 1174 1 PMID PMID NNP en-wikipedia-org-9224 1174 2   _SP en-wikipedia-org-9224 1174 3 15130835 15130835 CD en-wikipedia-org-9224 1174 4 . . . en-wikipedia-org-9224 1175 1 ^ ^ NFP en-wikipedia-org-9224 1175 2 Kanduc Kanduc NNP en-wikipedia-org-9224 1175 3 D D NNP en-wikipedia-org-9224 1175 4 ( ( -LRB- en-wikipedia-org-9224 1175 5 September September NNP en-wikipedia-org-9224 1175 6 2019 2019 CD en-wikipedia-org-9224 1175 7 ) ) -RRB- en-wikipedia-org-9224 1175 8 . . . en-wikipedia-org-9224 1176 1 " " `` en-wikipedia-org-9224 1176 2 From from IN en-wikipedia-org-9224 1176 3 hepatitis hepatitis NNP en-wikipedia-org-9224 1176 4 C C NNP en-wikipedia-org-9224 1176 5 virus virus NN en-wikipedia-org-9224 1176 6 immunoproteomics immunoproteomic NNS en-wikipedia-org-9224 1176 7 to to IN en-wikipedia-org-9224 1176 8 rheumatology rheumatology NN en-wikipedia-org-9224 1176 9 via via IN en-wikipedia-org-9224 1176 10 cross cross NN en-wikipedia-org-9224 1176 11 - - JJ en-wikipedia-org-9224 1176 12 reactivity reactivity NN en-wikipedia-org-9224 1176 13 in in IN en-wikipedia-org-9224 1176 14 one one CD en-wikipedia-org-9224 1176 15 table table NN en-wikipedia-org-9224 1176 16 " " '' en-wikipedia-org-9224 1176 17 . . . en-wikipedia-org-9224 1177 1 Current current JJ en-wikipedia-org-9224 1177 2 Opinion Opinion NNP en-wikipedia-org-9224 1177 3 in in IN en-wikipedia-org-9224 1177 4 Rheumatology Rheumatology NNP en-wikipedia-org-9224 1177 5 . . . en-wikipedia-org-9224 1178 1 31 31 CD en-wikipedia-org-9224 1178 2 ( ( -LRB- en-wikipedia-org-9224 1178 3 5 5 CD en-wikipedia-org-9224 1178 4 ) ) -RRB- en-wikipedia-org-9224 1178 5 : : : en-wikipedia-org-9224 1178 6 488–492 488–492 CD en-wikipedia-org-9224 1178 7 . . . en-wikipedia-org-9224 1179 1 doi:10.1097 doi:10.1097 NNP en-wikipedia-org-9224 1179 2 / / SYM en-wikipedia-org-9224 1179 3 BOR.0000000000000606 bor.0000000000000606 NN en-wikipedia-org-9224 1179 4 . . . en-wikipedia-org-9224 1180 1 PMID PMID NNP en-wikipedia-org-9224 1180 2   _SP en-wikipedia-org-9224 1180 3 31356379 31356379 CD en-wikipedia-org-9224 1180 4 . . . en-wikipedia-org-9224 1181 1 ^ ^ NNP en-wikipedia-org-9224 1181 2 a a DT en-wikipedia-org-9224 1181 3 b b NNP en-wikipedia-org-9224 1181 4 Flajnik Flajnik NNP en-wikipedia-org-9224 1181 5 MF MF NNP en-wikipedia-org-9224 1181 6 , , , en-wikipedia-org-9224 1181 7 Kasahara Kasahara NNP en-wikipedia-org-9224 1181 8 M M NNP en-wikipedia-org-9224 1181 9 ( ( -LRB- en-wikipedia-org-9224 1181 10 January January NNP en-wikipedia-org-9224 1181 11 2010 2010 CD en-wikipedia-org-9224 1181 12 ) ) -RRB- en-wikipedia-org-9224 1181 13 . . . en-wikipedia-org-9224 1182 1 " " `` en-wikipedia-org-9224 1182 2 Origin origin NN en-wikipedia-org-9224 1182 3 and and CC en-wikipedia-org-9224 1182 4 evolution evolution NN en-wikipedia-org-9224 1182 5 of of IN en-wikipedia-org-9224 1182 6 the the DT en-wikipedia-org-9224 1182 7 adaptive adaptive JJ en-wikipedia-org-9224 1182 8 immune immune JJ en-wikipedia-org-9224 1182 9 system system NN en-wikipedia-org-9224 1182 10 : : : en-wikipedia-org-9224 1182 11 genetic genetic JJ en-wikipedia-org-9224 1182 12 events event NNS en-wikipedia-org-9224 1182 13 and and CC en-wikipedia-org-9224 1182 14 selective selective JJ en-wikipedia-org-9224 1182 15 pressures pressure NNS en-wikipedia-org-9224 1182 16 " " '' en-wikipedia-org-9224 1182 17 . . . en-wikipedia-org-9224 1183 1 Nature Nature NNP en-wikipedia-org-9224 1183 2 Reviews Reviews NNPS en-wikipedia-org-9224 1183 3 . . . en-wikipedia-org-9224 1184 1 Genetics Genetics NNP en-wikipedia-org-9224 1184 2 . . . en-wikipedia-org-9224 1185 1 11 11 CD en-wikipedia-org-9224 1185 2 ( ( -LRB- en-wikipedia-org-9224 1185 3 1 1 CD en-wikipedia-org-9224 1185 4 ) ) -RRB- en-wikipedia-org-9224 1185 5 : : : en-wikipedia-org-9224 1185 6 47–59 47–59 CD en-wikipedia-org-9224 1185 7 . . . en-wikipedia-org-9224 1186 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 1186 2 / / SYM en-wikipedia-org-9224 1186 3 nrg2703 nrg2703 NNP en-wikipedia-org-9224 1186 4 . . . en-wikipedia-org-9224 1187 1 PMC PMC NNP en-wikipedia-org-9224 1187 2   _SP en-wikipedia-org-9224 1187 3 3805090 3805090 CD en-wikipedia-org-9224 1187 4 . . . en-wikipedia-org-9224 1188 1 PMID PMID NNP en-wikipedia-org-9224 1188 2   _SP en-wikipedia-org-9224 1188 3 19997068 19997068 CD en-wikipedia-org-9224 1188 4 . . . en-wikipedia-org-9224 1189 1 ^ ^ NFP en-wikipedia-org-9224 1189 2 Bickle Bickle NNP en-wikipedia-org-9224 1189 3 TA TA NNP en-wikipedia-org-9224 1189 4 , , , en-wikipedia-org-9224 1189 5 Krüger Krüger NNP en-wikipedia-org-9224 1189 6 DH DH NNP en-wikipedia-org-9224 1189 7 ( ( -LRB- en-wikipedia-org-9224 1189 8 June June NNP en-wikipedia-org-9224 1189 9 1993 1993 CD en-wikipedia-org-9224 1189 10 ) ) -RRB- en-wikipedia-org-9224 1189 11 . . . en-wikipedia-org-9224 1190 1 " " `` en-wikipedia-org-9224 1190 2 Biology Biology NNP en-wikipedia-org-9224 1190 3 of of IN en-wikipedia-org-9224 1190 4 DNA dna NN en-wikipedia-org-9224 1190 5 restriction restriction NN en-wikipedia-org-9224 1190 6 " " '' en-wikipedia-org-9224 1190 7 . . . en-wikipedia-org-9224 1191 1 Microbiological Microbiological NNP en-wikipedia-org-9224 1191 2 Reviews Reviews NNPS en-wikipedia-org-9224 1191 3 . . . en-wikipedia-org-9224 1192 1 57 57 CD en-wikipedia-org-9224 1192 2 ( ( -LRB- en-wikipedia-org-9224 1192 3 2 2 CD en-wikipedia-org-9224 1192 4 ) ) -RRB- en-wikipedia-org-9224 1192 5 : : : en-wikipedia-org-9224 1192 6 434–50 434–50 CD en-wikipedia-org-9224 1192 7 . . . en-wikipedia-org-9224 1193 1 doi:10.1128 doi:10.1128 NNP en-wikipedia-org-9224 1193 2 / / SYM en-wikipedia-org-9224 1193 3 MMBR.57.2.434 MMBR.57.2.434 NNP en-wikipedia-org-9224 1193 4 - - HYPH en-wikipedia-org-9224 1193 5 450.1993 450.1993 NNP en-wikipedia-org-9224 1193 6 . . . en-wikipedia-org-9224 1194 1 PMC PMC NNP en-wikipedia-org-9224 1194 2   _SP en-wikipedia-org-9224 1194 3 372918 372918 CD en-wikipedia-org-9224 1194 4 . . . en-wikipedia-org-9224 1195 1 PMID PMID NNP en-wikipedia-org-9224 1195 2   _SP en-wikipedia-org-9224 1195 3 8336674 8336674 CD en-wikipedia-org-9224 1195 4 . . . en-wikipedia-org-9224 1196 1 ^ ^ NFP en-wikipedia-org-9224 1196 2 Barrangou Barrangou NNP en-wikipedia-org-9224 1196 3 R R NNP en-wikipedia-org-9224 1196 4 , , , en-wikipedia-org-9224 1196 5 Fremaux Fremaux NNP en-wikipedia-org-9224 1196 6 C C NNP en-wikipedia-org-9224 1196 7 , , , en-wikipedia-org-9224 1196 8 Deveau Deveau NNP en-wikipedia-org-9224 1196 9 H H NNP en-wikipedia-org-9224 1196 10 , , , en-wikipedia-org-9224 1196 11 Richards Richards NNP en-wikipedia-org-9224 1196 12 M M NNP en-wikipedia-org-9224 1196 13 , , , en-wikipedia-org-9224 1196 14 Boyaval Boyaval NNP en-wikipedia-org-9224 1196 15 P P NNP en-wikipedia-org-9224 1196 16 , , , en-wikipedia-org-9224 1196 17 Moineau Moineau NNP en-wikipedia-org-9224 1196 18 S S NNP en-wikipedia-org-9224 1196 19 , , , en-wikipedia-org-9224 1196 20 Romero Romero NNP en-wikipedia-org-9224 1196 21 DA DA NNP en-wikipedia-org-9224 1196 22 , , , en-wikipedia-org-9224 1196 23 Horvath Horvath NNP en-wikipedia-org-9224 1196 24 P P NNP en-wikipedia-org-9224 1196 25 ( ( -LRB- en-wikipedia-org-9224 1196 26 March March NNP en-wikipedia-org-9224 1196 27 2007 2007 CD en-wikipedia-org-9224 1196 28 ) ) -RRB- en-wikipedia-org-9224 1196 29 . . . en-wikipedia-org-9224 1197 1 " " `` en-wikipedia-org-9224 1197 2 CRISPR CRISPR NNP en-wikipedia-org-9224 1197 3 provides provide VBZ en-wikipedia-org-9224 1197 4 acquired acquire VBN en-wikipedia-org-9224 1197 5 resistance resistance NN en-wikipedia-org-9224 1197 6 against against IN en-wikipedia-org-9224 1197 7 viruses virus NNS en-wikipedia-org-9224 1197 8 in in IN en-wikipedia-org-9224 1197 9 prokaryotes prokaryotes NNP en-wikipedia-org-9224 1197 10 " " '' en-wikipedia-org-9224 1197 11 . . . en-wikipedia-org-9224 1198 1 Science science NN en-wikipedia-org-9224 1198 2 . . . en-wikipedia-org-9224 1199 1 315 315 CD en-wikipedia-org-9224 1199 2 ( ( -LRB- en-wikipedia-org-9224 1199 3 5819 5819 CD en-wikipedia-org-9224 1199 4 ) ) -RRB- en-wikipedia-org-9224 1199 5 : : : en-wikipedia-org-9224 1199 6 1709–12 1709–12 LS en-wikipedia-org-9224 1199 7 . . . en-wikipedia-org-9224 1200 1 Bibcode:2007Sci bibcode:2007sci UH en-wikipedia-org-9224 1200 2 ... ... NFP en-wikipedia-org-9224 1200 3 315.1709B. 315.1709b. LS en-wikipedia-org-9224 1201 1 doi:10.1126 doi:10.1126 VB en-wikipedia-org-9224 1201 2 / / SYM en-wikipedia-org-9224 1201 3 science.1138140 science.1138140 NN en-wikipedia-org-9224 1201 4 . . . en-wikipedia-org-9224 1202 1 hdl:20.500.11794/38902 hdl:20.500.11794/38902 JJ en-wikipedia-org-9224 1202 2 . . . en-wikipedia-org-9224 1203 1 PMID PMID NNP en-wikipedia-org-9224 1203 2   _SP en-wikipedia-org-9224 1203 3 17379808 17379808 CD en-wikipedia-org-9224 1203 4 . . . en-wikipedia-org-9224 1204 1 S2CID S2CID NNS en-wikipedia-org-9224 1204 2   _SP en-wikipedia-org-9224 1204 3 3888761 3888761 CD en-wikipedia-org-9224 1204 4 . . . en-wikipedia-org-9224 1205 1 ^ ^ NN en-wikipedia-org-9224 1205 2 Brouns Brouns NNP en-wikipedia-org-9224 1205 3 SJ SJ NNP en-wikipedia-org-9224 1205 4 , , , en-wikipedia-org-9224 1205 5 Jore Jore NNP en-wikipedia-org-9224 1205 6 MM MM NNP en-wikipedia-org-9224 1205 7 , , , en-wikipedia-org-9224 1205 8 Lundgren Lundgren NNP en-wikipedia-org-9224 1205 9 M M NNP en-wikipedia-org-9224 1205 10 , , , en-wikipedia-org-9224 1205 11 Westra Westra NNP en-wikipedia-org-9224 1205 12 ER ER NNP en-wikipedia-org-9224 1205 13 , , , en-wikipedia-org-9224 1205 14 Slijkhuis Slijkhuis NNP en-wikipedia-org-9224 1205 15 RJ RJ NNP en-wikipedia-org-9224 1205 16 , , , en-wikipedia-org-9224 1205 17 Snijders Snijders NNP en-wikipedia-org-9224 1205 18 AP AP NNP en-wikipedia-org-9224 1205 19 , , , en-wikipedia-org-9224 1205 20 Dickman Dickman NNP en-wikipedia-org-9224 1205 21 MJ MJ NNP en-wikipedia-org-9224 1205 22 , , , en-wikipedia-org-9224 1205 23 Makarova Makarova NNP en-wikipedia-org-9224 1205 24 KS KS NNP en-wikipedia-org-9224 1205 25 , , , en-wikipedia-org-9224 1205 26 Koonin Koonin NNP en-wikipedia-org-9224 1205 27 EV EV NNP en-wikipedia-org-9224 1205 28 , , , en-wikipedia-org-9224 1205 29 van van NNP en-wikipedia-org-9224 1205 30 der der XX en-wikipedia-org-9224 1205 31 Oost Oost NNP en-wikipedia-org-9224 1205 32 J J NNP en-wikipedia-org-9224 1205 33 ( ( -LRB- en-wikipedia-org-9224 1205 34 August August NNP en-wikipedia-org-9224 1205 35 2008 2008 CD en-wikipedia-org-9224 1205 36 ) ) -RRB- en-wikipedia-org-9224 1205 37 . . . en-wikipedia-org-9224 1206 1 " " `` en-wikipedia-org-9224 1206 2 Small small JJ en-wikipedia-org-9224 1206 3 CRISPR CRISPR NNP en-wikipedia-org-9224 1206 4 RNAs rna NNS en-wikipedia-org-9224 1206 5 guide guide VBP en-wikipedia-org-9224 1206 6 antiviral antiviral JJ en-wikipedia-org-9224 1206 7 defense defense NN en-wikipedia-org-9224 1206 8 in in IN en-wikipedia-org-9224 1206 9 prokaryotes prokaryotes NNP en-wikipedia-org-9224 1206 10 " " '' en-wikipedia-org-9224 1206 11 . . . en-wikipedia-org-9224 1207 1 Science science NN en-wikipedia-org-9224 1207 2 . . . en-wikipedia-org-9224 1208 1 321 321 CD en-wikipedia-org-9224 1208 2 ( ( -LRB- en-wikipedia-org-9224 1208 3 5891 5891 CD en-wikipedia-org-9224 1208 4 ) ) -RRB- en-wikipedia-org-9224 1208 5 : : : en-wikipedia-org-9224 1208 6 960–64 960–64 CD en-wikipedia-org-9224 1208 7 . . . en-wikipedia-org-9224 1209 1 Bibcode:2008Sci bibcode:2008sci CD en-wikipedia-org-9224 1209 2 ... ... NFP en-wikipedia-org-9224 1209 3 321 321 CD en-wikipedia-org-9224 1209 4 .. .. NFP en-wikipedia-org-9224 1209 5 960B. 960b. CD en-wikipedia-org-9224 1210 1 doi:10.1126 doi:10.1126 NN en-wikipedia-org-9224 1210 2 / / SYM en-wikipedia-org-9224 1210 3 science.1159689 science.1159689 NN en-wikipedia-org-9224 1210 4 . . . en-wikipedia-org-9224 1211 1 PMC PMC NNP en-wikipedia-org-9224 1211 2   _SP en-wikipedia-org-9224 1211 3 5898235 5898235 CD en-wikipedia-org-9224 1211 4 . . . en-wikipedia-org-9224 1212 1 PMID PMID NNP en-wikipedia-org-9224 1212 2   _SP en-wikipedia-org-9224 1212 3 18703739 18703739 CD en-wikipedia-org-9224 1212 4 . . . en-wikipedia-org-9224 1213 1 ^ ^ NNP en-wikipedia-org-9224 1213 2 Hille Hille NNP en-wikipedia-org-9224 1213 3 F F NNP en-wikipedia-org-9224 1213 4 , , , en-wikipedia-org-9224 1213 5 Charpentier Charpentier NNP en-wikipedia-org-9224 1213 6 E E NNP en-wikipedia-org-9224 1213 7 ( ( -LRB- en-wikipedia-org-9224 1213 8 November November NNP en-wikipedia-org-9224 1213 9 2016 2016 CD en-wikipedia-org-9224 1213 10 ) ) -RRB- en-wikipedia-org-9224 1213 11 . . . en-wikipedia-org-9224 1214 1 " " `` en-wikipedia-org-9224 1214 2 CRISPR CRISPR NNP en-wikipedia-org-9224 1214 3 - - HYPH en-wikipedia-org-9224 1214 4 Cas Cas NNP en-wikipedia-org-9224 1214 5 : : : en-wikipedia-org-9224 1214 6 biology biology NN en-wikipedia-org-9224 1214 7 , , , en-wikipedia-org-9224 1214 8 mechanisms mechanism NNS en-wikipedia-org-9224 1214 9 and and CC en-wikipedia-org-9224 1214 10 relevance relevance NN en-wikipedia-org-9224 1214 11 " " '' en-wikipedia-org-9224 1214 12 . . . en-wikipedia-org-9224 1215 1 Philosophical philosophical JJ en-wikipedia-org-9224 1215 2 Transactions Transactions NNPS en-wikipedia-org-9224 1215 3 of of IN en-wikipedia-org-9224 1215 4 the the DT en-wikipedia-org-9224 1215 5 Royal Royal NNP en-wikipedia-org-9224 1215 6 Society Society NNP en-wikipedia-org-9224 1215 7 of of IN en-wikipedia-org-9224 1215 8 London London NNP en-wikipedia-org-9224 1215 9 . . . en-wikipedia-org-9224 1216 1 Series Series NNP en-wikipedia-org-9224 1216 2 B B NNP en-wikipedia-org-9224 1216 3 , , , en-wikipedia-org-9224 1216 4 Biological Biological NNP en-wikipedia-org-9224 1216 5 Sciences Sciences NNPS en-wikipedia-org-9224 1216 6 . . . en-wikipedia-org-9224 1217 1 371 371 CD en-wikipedia-org-9224 1217 2 ( ( -LRB- en-wikipedia-org-9224 1217 3 1707 1707 CD en-wikipedia-org-9224 1217 4 ) ) -RRB- en-wikipedia-org-9224 1217 5 : : : en-wikipedia-org-9224 1217 6 20150496 20150496 CD en-wikipedia-org-9224 1217 7 . . . en-wikipedia-org-9224 1217 8 doi:10.1098 doi:10.1098 NNP en-wikipedia-org-9224 1217 9 / / SYM en-wikipedia-org-9224 1217 10 rstb.2015.0496 rstb.2015.0496 NNP en-wikipedia-org-9224 1217 11 . . . en-wikipedia-org-9224 1218 1 PMC PMC NNP en-wikipedia-org-9224 1218 2   _SP en-wikipedia-org-9224 1218 3 5052741 5052741 CD en-wikipedia-org-9224 1218 4 . . . en-wikipedia-org-9224 1219 1 PMID PMID NNP en-wikipedia-org-9224 1219 2   _SP en-wikipedia-org-9224 1219 3 27672148 27672148 CD en-wikipedia-org-9224 1219 4 . . . en-wikipedia-org-9224 1220 1 ^ ^ NFP en-wikipedia-org-9224 1220 2 Koonin Koonin NNP en-wikipedia-org-9224 1220 3 EV EV NNP en-wikipedia-org-9224 1220 4 ( ( -LRB- en-wikipedia-org-9224 1220 5 February February NNP en-wikipedia-org-9224 1220 6 2017 2017 CD en-wikipedia-org-9224 1220 7 ) ) -RRB- en-wikipedia-org-9224 1220 8 . . . en-wikipedia-org-9224 1221 1 " " `` en-wikipedia-org-9224 1221 2 Evolution Evolution NNP en-wikipedia-org-9224 1221 3 of of IN en-wikipedia-org-9224 1221 4 RNA- RNA- NNP en-wikipedia-org-9224 1221 5 and and CC en-wikipedia-org-9224 1221 6 DNA DNA NNP en-wikipedia-org-9224 1221 7 - - HYPH en-wikipedia-org-9224 1221 8 guided guide VBN en-wikipedia-org-9224 1221 9 antivirus antivirus NN en-wikipedia-org-9224 1221 10 defense defense NN en-wikipedia-org-9224 1221 11 systems system NNS en-wikipedia-org-9224 1221 12 in in IN en-wikipedia-org-9224 1221 13 prokaryotes prokaryote NNS en-wikipedia-org-9224 1221 14 and and CC en-wikipedia-org-9224 1221 15 eukaryotes eukaryote NNS en-wikipedia-org-9224 1221 16 : : : en-wikipedia-org-9224 1221 17 common common JJ en-wikipedia-org-9224 1221 18 ancestry ancestry NN en-wikipedia-org-9224 1221 19 vs vs IN en-wikipedia-org-9224 1221 20 convergence convergence NNP en-wikipedia-org-9224 1221 21 " " '' en-wikipedia-org-9224 1221 22 . . . en-wikipedia-org-9224 1222 1 Biology biology NN en-wikipedia-org-9224 1222 2 Direct Direct NNP en-wikipedia-org-9224 1222 3 . . . en-wikipedia-org-9224 1223 1 12 12 CD en-wikipedia-org-9224 1223 2 ( ( -LRB- en-wikipedia-org-9224 1223 3 1 1 CD en-wikipedia-org-9224 1223 4 ) ) -RRB- en-wikipedia-org-9224 1223 5 : : : en-wikipedia-org-9224 1223 6 5 5 CD en-wikipedia-org-9224 1223 7 . . . en-wikipedia-org-9224 1223 8 doi:10.1186 doi:10.1186 NNP en-wikipedia-org-9224 1223 9 / / SYM en-wikipedia-org-9224 1223 10 s13062 s13062 NNP en-wikipedia-org-9224 1223 11 - - HYPH en-wikipedia-org-9224 1223 12 017 017 CD en-wikipedia-org-9224 1223 13 - - HYPH en-wikipedia-org-9224 1223 14 0177 0177 CD en-wikipedia-org-9224 1223 15 - - HYPH en-wikipedia-org-9224 1223 16 2 2 CD en-wikipedia-org-9224 1223 17 . . . en-wikipedia-org-9224 1224 1 PMC PMC NNP en-wikipedia-org-9224 1224 2   _SP en-wikipedia-org-9224 1224 3 5303251 5303251 CD en-wikipedia-org-9224 1224 4 . . . en-wikipedia-org-9224 1225 1 PMID PMID NNP en-wikipedia-org-9224 1225 2   _SP en-wikipedia-org-9224 1225 3 28187792 28187792 CD en-wikipedia-org-9224 1225 4 . . . en-wikipedia-org-9224 1226 1 ^ ^ NNP en-wikipedia-org-9224 1226 2 Bayne Bayne NNP en-wikipedia-org-9224 1226 3 CJ CJ NNP en-wikipedia-org-9224 1226 4 ( ( -LRB- en-wikipedia-org-9224 1226 5 2003 2003 CD en-wikipedia-org-9224 1226 6 ) ) -RRB- en-wikipedia-org-9224 1226 7 . . . en-wikipedia-org-9224 1227 1 " " `` en-wikipedia-org-9224 1227 2 Origins origin NNS en-wikipedia-org-9224 1227 3 and and CC en-wikipedia-org-9224 1227 4 evolutionary evolutionary JJ en-wikipedia-org-9224 1227 5 relationships relationship NNS en-wikipedia-org-9224 1227 6 between between IN en-wikipedia-org-9224 1227 7 the the DT en-wikipedia-org-9224 1227 8 innate innate JJ en-wikipedia-org-9224 1227 9 and and CC en-wikipedia-org-9224 1227 10 adaptive adaptive JJ en-wikipedia-org-9224 1227 11 arms arm NNS en-wikipedia-org-9224 1227 12 of of IN en-wikipedia-org-9224 1227 13 immune immune JJ en-wikipedia-org-9224 1227 14 systems system NNS en-wikipedia-org-9224 1227 15 " " '' en-wikipedia-org-9224 1227 16 . . . en-wikipedia-org-9224 1228 1 Integr Integr NNP en-wikipedia-org-9224 1228 2 . . . en-wikipedia-org-9224 1229 1 Comp Comp NNP en-wikipedia-org-9224 1229 2 . . . en-wikipedia-org-9224 1230 1 Biol Biol NNP en-wikipedia-org-9224 1230 2 . . . en-wikipedia-org-9224 1231 1 43 43 CD en-wikipedia-org-9224 1231 2 ( ( -LRB- en-wikipedia-org-9224 1231 3 2 2 CD en-wikipedia-org-9224 1231 4 ) ) -RRB- en-wikipedia-org-9224 1231 5 : : : en-wikipedia-org-9224 1231 6 293–99 293–99 CD en-wikipedia-org-9224 1231 7 . . . en-wikipedia-org-9224 1232 1 doi:10.1093 doi:10.1093 NNP en-wikipedia-org-9224 1232 2 / / SYM en-wikipedia-org-9224 1232 3 icb/43.2.293 icb/43.2.293 NNP en-wikipedia-org-9224 1232 4 . . . en-wikipedia-org-9224 1233 1 PMID PMID NNP en-wikipedia-org-9224 1233 2   _SP en-wikipedia-org-9224 1233 3 21680436 21680436 CD en-wikipedia-org-9224 1233 4 . . . en-wikipedia-org-9224 1234 1 ^ ^ NFP en-wikipedia-org-9224 1234 2 Stram Stram NNP en-wikipedia-org-9224 1234 3 Y Y NNP en-wikipedia-org-9224 1234 4 , , , en-wikipedia-org-9224 1234 5 Kuzntzova Kuzntzova NNP en-wikipedia-org-9224 1234 6 L L NNP en-wikipedia-org-9224 1234 7 ( ( -LRB- en-wikipedia-org-9224 1234 8 June June NNP en-wikipedia-org-9224 1234 9 2006 2006 CD en-wikipedia-org-9224 1234 10 ) ) -RRB- en-wikipedia-org-9224 1234 11 . . . en-wikipedia-org-9224 1235 1 " " `` en-wikipedia-org-9224 1235 2 Inhibition inhibition NN en-wikipedia-org-9224 1235 3 of of IN en-wikipedia-org-9224 1235 4 viruses virus NNS en-wikipedia-org-9224 1235 5 by by IN en-wikipedia-org-9224 1235 6 RNA RNA NNP en-wikipedia-org-9224 1235 7 interference interference NN en-wikipedia-org-9224 1235 8 " " '' en-wikipedia-org-9224 1235 9 . . . en-wikipedia-org-9224 1236 1 Virus Virus NNP en-wikipedia-org-9224 1236 2 Genes Genes NNP en-wikipedia-org-9224 1236 3 . . . en-wikipedia-org-9224 1237 1 32 32 CD en-wikipedia-org-9224 1237 2 ( ( -LRB- en-wikipedia-org-9224 1237 3 3 3 CD en-wikipedia-org-9224 1237 4 ) ) -RRB- en-wikipedia-org-9224 1237 5 : : : en-wikipedia-org-9224 1237 6 299–306 299–306 CD en-wikipedia-org-9224 1237 7 . . . en-wikipedia-org-9224 1238 1 doi:10.1007 doi:10.1007 NNP en-wikipedia-org-9224 1238 2 / / SYM en-wikipedia-org-9224 1238 3 s11262 s11262 NNP en-wikipedia-org-9224 1238 4 - - HYPH en-wikipedia-org-9224 1238 5 005 005 CD en-wikipedia-org-9224 1238 6 - - HYPH en-wikipedia-org-9224 1238 7 6914 6914 CD en-wikipedia-org-9224 1238 8 - - HYPH en-wikipedia-org-9224 1238 9 0 0 CD en-wikipedia-org-9224 1238 10 . . . en-wikipedia-org-9224 1239 1 PMC PMC NNP en-wikipedia-org-9224 1239 2   _SP en-wikipedia-org-9224 1239 3 7088519 7088519 CD en-wikipedia-org-9224 1239 4 . . . en-wikipedia-org-9224 1240 1 PMID PMID NNP en-wikipedia-org-9224 1240 2   _SP en-wikipedia-org-9224 1240 3 16732482 16732482 CD en-wikipedia-org-9224 1240 4 . . . en-wikipedia-org-9224 1241 1 ^ ^ NNP en-wikipedia-org-9224 1241 2 a a DT en-wikipedia-org-9224 1241 3 b b NNP en-wikipedia-org-9224 1241 4 Schneider Schneider NNP en-wikipedia-org-9224 1241 5 D. D. NNP en-wikipedia-org-9224 1241 6 " " '' en-wikipedia-org-9224 1241 7 Innate Innate NNP en-wikipedia-org-9224 1241 8 Immunity immunity NN en-wikipedia-org-9224 1241 9   _SP en-wikipedia-org-9224 1241 10 – – : en-wikipedia-org-9224 1241 11 Lecture lecture NN en-wikipedia-org-9224 1241 12 4 4 CD en-wikipedia-org-9224 1241 13 : : : en-wikipedia-org-9224 1241 14 Plant plant NN en-wikipedia-org-9224 1241 15 immune immune JJ en-wikipedia-org-9224 1241 16 responses response NNS en-wikipedia-org-9224 1241 17 " " '' en-wikipedia-org-9224 1241 18 ( ( -LRB- en-wikipedia-org-9224 1241 19 PDF PDF NNP en-wikipedia-org-9224 1241 20 ) ) -RRB- en-wikipedia-org-9224 1241 21 . . . en-wikipedia-org-9224 1242 1 Stanford Stanford NNP en-wikipedia-org-9224 1242 2 University University NNP en-wikipedia-org-9224 1242 3 Department Department NNP en-wikipedia-org-9224 1242 4 of of IN en-wikipedia-org-9224 1242 5 Microbiology Microbiology NNP en-wikipedia-org-9224 1242 6 and and CC en-wikipedia-org-9224 1242 7 Immunology Immunology NNP en-wikipedia-org-9224 1242 8 . . . en-wikipedia-org-9224 1243 1 Retrieved Retrieved NNP en-wikipedia-org-9224 1243 2 1 1 CD en-wikipedia-org-9224 1243 3 January January NNP en-wikipedia-org-9224 1243 4 2007 2007 CD en-wikipedia-org-9224 1243 5 . . . en-wikipedia-org-9224 1244 1 ^ ^ NNP en-wikipedia-org-9224 1244 2 Jones Jones NNP en-wikipedia-org-9224 1244 3 JD JD NNP en-wikipedia-org-9224 1244 4 , , , en-wikipedia-org-9224 1244 5 Dangl Dangl NNP en-wikipedia-org-9224 1244 6 JL JL NNP en-wikipedia-org-9224 1244 7 ( ( -LRB- en-wikipedia-org-9224 1244 8 November November NNP en-wikipedia-org-9224 1244 9 2006 2006 CD en-wikipedia-org-9224 1244 10 ) ) -RRB- en-wikipedia-org-9224 1244 11 . . . en-wikipedia-org-9224 1245 1 " " `` en-wikipedia-org-9224 1245 2 The the DT en-wikipedia-org-9224 1245 3 plant plant NN en-wikipedia-org-9224 1245 4 immune immune JJ en-wikipedia-org-9224 1245 5 system system NN en-wikipedia-org-9224 1245 6 " " '' en-wikipedia-org-9224 1245 7 . . . en-wikipedia-org-9224 1246 1 Nature nature NN en-wikipedia-org-9224 1246 2 . . . en-wikipedia-org-9224 1247 1 444 444 CD en-wikipedia-org-9224 1247 2 ( ( -LRB- en-wikipedia-org-9224 1247 3 7117 7117 CD en-wikipedia-org-9224 1247 4 ) ) -RRB- en-wikipedia-org-9224 1247 5 : : : en-wikipedia-org-9224 1247 6 323–29 323–29 CD en-wikipedia-org-9224 1247 7 . . . en-wikipedia-org-9224 1248 1 Bibcode:2006Natur.444 Bibcode:2006Natur.444 NFP en-wikipedia-org-9224 1248 2 .. .. NFP en-wikipedia-org-9224 1248 3 323J. 323j. CD en-wikipedia-org-9224 1249 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 1249 2 / / SYM en-wikipedia-org-9224 1249 3 nature05286 nature05286 NNP en-wikipedia-org-9224 1249 4 . . . en-wikipedia-org-9224 1250 1 PMID PMID NNP en-wikipedia-org-9224 1250 2   _SP en-wikipedia-org-9224 1250 3 17108957 17108957 CD en-wikipedia-org-9224 1250 4 . . . en-wikipedia-org-9224 1251 1 ^ ^ NFP en-wikipedia-org-9224 1251 2 Baulcombe Baulcombe NNP en-wikipedia-org-9224 1251 3 D D NNP en-wikipedia-org-9224 1251 4 ( ( -LRB- en-wikipedia-org-9224 1251 5 September September NNP en-wikipedia-org-9224 1251 6 2004 2004 CD en-wikipedia-org-9224 1251 7 ) ) -RRB- en-wikipedia-org-9224 1251 8 . . . en-wikipedia-org-9224 1252 1 " " `` en-wikipedia-org-9224 1252 2 RNA RNA NNP en-wikipedia-org-9224 1252 3 silencing silence VBG en-wikipedia-org-9224 1252 4 in in IN en-wikipedia-org-9224 1252 5 plants plant NNS en-wikipedia-org-9224 1252 6 " " '' en-wikipedia-org-9224 1252 7 . . . en-wikipedia-org-9224 1253 1 Nature nature NN en-wikipedia-org-9224 1253 2 . . . en-wikipedia-org-9224 1254 1 431 431 CD en-wikipedia-org-9224 1254 2 ( ( -LRB- en-wikipedia-org-9224 1254 3 7006 7006 CD en-wikipedia-org-9224 1254 4 ) ) -RRB- en-wikipedia-org-9224 1254 5 : : : en-wikipedia-org-9224 1254 6 356–63 356–63 CD en-wikipedia-org-9224 1254 7 . . . en-wikipedia-org-9224 1255 1 Bibcode:2004Natur.431 Bibcode:2004Natur.431 NNP en-wikipedia-org-9224 1255 2 .. .. NFP en-wikipedia-org-9224 1255 3 356B. 356b. CD en-wikipedia-org-9224 1256 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 1256 2 / / SYM en-wikipedia-org-9224 1256 3 nature02874 nature02874 NNP en-wikipedia-org-9224 1256 4 . . . en-wikipedia-org-9224 1257 1 PMID PMID NNP en-wikipedia-org-9224 1257 2   _SP en-wikipedia-org-9224 1257 3 15372043 15372043 CD en-wikipedia-org-9224 1257 4 . . . en-wikipedia-org-9224 1258 1 S2CID S2CID NNS en-wikipedia-org-9224 1258 2   _SP en-wikipedia-org-9224 1258 3 4421274 4421274 CD en-wikipedia-org-9224 1258 4 . . . en-wikipedia-org-9224 1259 1 ^ ^ NNP en-wikipedia-org-9224 1259 2 Alder Alder NNP en-wikipedia-org-9224 1259 3 MN MN NNP en-wikipedia-org-9224 1259 4 , , , en-wikipedia-org-9224 1259 5 Rogozin Rogozin NNP en-wikipedia-org-9224 1259 6 IB IB NNP en-wikipedia-org-9224 1259 7 , , , en-wikipedia-org-9224 1259 8 Iyer Iyer NNP en-wikipedia-org-9224 1259 9 LM LM NNP en-wikipedia-org-9224 1259 10 , , , en-wikipedia-org-9224 1259 11 Glazko Glazko NNP en-wikipedia-org-9224 1259 12 GV GV NNP en-wikipedia-org-9224 1259 13 , , , en-wikipedia-org-9224 1259 14 Cooper Cooper NNP en-wikipedia-org-9224 1259 15 MD MD NNP en-wikipedia-org-9224 1259 16 , , , en-wikipedia-org-9224 1259 17 Pancer Pancer NNP en-wikipedia-org-9224 1259 18 Z Z NNP en-wikipedia-org-9224 1259 19 ( ( -LRB- en-wikipedia-org-9224 1259 20 December December NNP en-wikipedia-org-9224 1259 21 2005 2005 CD en-wikipedia-org-9224 1259 22 ) ) -RRB- en-wikipedia-org-9224 1259 23 . . . en-wikipedia-org-9224 1260 1 " " `` en-wikipedia-org-9224 1260 2 Diversity diversity NN en-wikipedia-org-9224 1260 3 and and CC en-wikipedia-org-9224 1260 4 function function NN en-wikipedia-org-9224 1260 5 of of IN en-wikipedia-org-9224 1260 6 adaptive adaptive JJ en-wikipedia-org-9224 1260 7 immune immune JJ en-wikipedia-org-9224 1260 8 receptors receptor NNS en-wikipedia-org-9224 1260 9 in in IN en-wikipedia-org-9224 1260 10 a a DT en-wikipedia-org-9224 1260 11 jawless jawless NN en-wikipedia-org-9224 1260 12 vertebrate vertebrate NN en-wikipedia-org-9224 1260 13 " " '' en-wikipedia-org-9224 1260 14 . . . en-wikipedia-org-9224 1261 1 Science science NN en-wikipedia-org-9224 1261 2 . . . en-wikipedia-org-9224 1262 1 310 310 CD en-wikipedia-org-9224 1262 2 ( ( -LRB- en-wikipedia-org-9224 1262 3 5756 5756 CD en-wikipedia-org-9224 1262 4 ) ) -RRB- en-wikipedia-org-9224 1262 5 : : : en-wikipedia-org-9224 1262 6 1970–73 1970–73 LS en-wikipedia-org-9224 1262 7 . . . en-wikipedia-org-9224 1263 1 Bibcode:2005Sci Bibcode:2005Sci NNS en-wikipedia-org-9224 1263 2 ... ... NFP en-wikipedia-org-9224 1263 3 310.1970A. 310.1970a. NN en-wikipedia-org-9224 1264 1 doi:10.1126 doi:10.1126 VB en-wikipedia-org-9224 1264 2 / / SYM en-wikipedia-org-9224 1264 3 science.1119420 science.1119420 NN en-wikipedia-org-9224 1264 4 . . . en-wikipedia-org-9224 1265 1 PMID PMID NNP en-wikipedia-org-9224 1265 2   _SP en-wikipedia-org-9224 1265 3 16373579 16373579 CD en-wikipedia-org-9224 1265 4 . . . en-wikipedia-org-9224 1266 1 ^ ^ NNP en-wikipedia-org-9224 1266 2 a a DT en-wikipedia-org-9224 1266 3 b b NNP en-wikipedia-org-9224 1266 4 Finlay Finlay NNP en-wikipedia-org-9224 1266 5 BB BB NNP en-wikipedia-org-9224 1266 6 , , , en-wikipedia-org-9224 1266 7 McFadden McFadden NNP en-wikipedia-org-9224 1266 8 G G NNP en-wikipedia-org-9224 1266 9 ( ( -LRB- en-wikipedia-org-9224 1266 10 February February NNP en-wikipedia-org-9224 1266 11 2006 2006 CD en-wikipedia-org-9224 1266 12 ) ) -RRB- en-wikipedia-org-9224 1266 13 . . . en-wikipedia-org-9224 1267 1 " " `` en-wikipedia-org-9224 1267 2 Anti anti JJ en-wikipedia-org-9224 1267 3 - - NN en-wikipedia-org-9224 1267 4 immunology immunology NN en-wikipedia-org-9224 1267 5 : : : en-wikipedia-org-9224 1267 6 evasion evasion NN en-wikipedia-org-9224 1267 7 of of IN en-wikipedia-org-9224 1267 8 the the DT en-wikipedia-org-9224 1267 9 host host NN en-wikipedia-org-9224 1267 10 immune immune JJ en-wikipedia-org-9224 1267 11 system system NN en-wikipedia-org-9224 1267 12 by by IN en-wikipedia-org-9224 1267 13 bacterial bacterial JJ en-wikipedia-org-9224 1267 14 and and CC en-wikipedia-org-9224 1267 15 viral viral JJ en-wikipedia-org-9224 1267 16 pathogens pathogen NNS en-wikipedia-org-9224 1267 17 " " '' en-wikipedia-org-9224 1267 18 . . . en-wikipedia-org-9224 1268 1 Cell cell NN en-wikipedia-org-9224 1268 2 . . . en-wikipedia-org-9224 1269 1 124 124 CD en-wikipedia-org-9224 1269 2 ( ( -LRB- en-wikipedia-org-9224 1269 3 4 4 CD en-wikipedia-org-9224 1269 4 ) ) -RRB- en-wikipedia-org-9224 1269 5 : : : en-wikipedia-org-9224 1269 6 767–82 767–82 CD en-wikipedia-org-9224 1269 7 . . . en-wikipedia-org-9224 1270 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 1270 2 / / SYM en-wikipedia-org-9224 1270 3 j.cell.2006.01.034 j.cell.2006.01.034 CD en-wikipedia-org-9224 1270 4 . . . en-wikipedia-org-9224 1271 1 PMID PMID NNP en-wikipedia-org-9224 1271 2   _SP en-wikipedia-org-9224 1271 3 16497587 16497587 CD en-wikipedia-org-9224 1271 4 . . . en-wikipedia-org-9224 1272 1 S2CID S2CID NNS en-wikipedia-org-9224 1272 2   _SP en-wikipedia-org-9224 1272 3 15418509 15418509 CD en-wikipedia-org-9224 1272 4 . . . en-wikipedia-org-9224 1273 1 ^ ^ NFP en-wikipedia-org-9224 1273 2 Cianciotto Cianciotto NNP en-wikipedia-org-9224 1273 3 NP NP NNP en-wikipedia-org-9224 1273 4 ( ( -LRB- en-wikipedia-org-9224 1273 5 December December NNP en-wikipedia-org-9224 1273 6 2005 2005 CD en-wikipedia-org-9224 1273 7 ) ) -RRB- en-wikipedia-org-9224 1273 8 . . . en-wikipedia-org-9224 1274 1 " " `` en-wikipedia-org-9224 1274 2 Type Type NNP en-wikipedia-org-9224 1274 3 II II NNP en-wikipedia-org-9224 1274 4 secretion secretion NN en-wikipedia-org-9224 1274 5 : : : en-wikipedia-org-9224 1274 6 a a DT en-wikipedia-org-9224 1274 7 protein protein NN en-wikipedia-org-9224 1274 8 secretion secretion NN en-wikipedia-org-9224 1274 9 system system NN en-wikipedia-org-9224 1274 10 for for IN en-wikipedia-org-9224 1274 11 all all DT en-wikipedia-org-9224 1274 12 seasons season NNS en-wikipedia-org-9224 1274 13 " " '' en-wikipedia-org-9224 1274 14 . . . en-wikipedia-org-9224 1275 1 Trends trend NNS en-wikipedia-org-9224 1275 2 in in IN en-wikipedia-org-9224 1275 3 Microbiology Microbiology NNP en-wikipedia-org-9224 1275 4 . . . en-wikipedia-org-9224 1276 1 13 13 CD en-wikipedia-org-9224 1276 2 ( ( -LRB- en-wikipedia-org-9224 1276 3 12 12 CD en-wikipedia-org-9224 1276 4 ) ) -RRB- en-wikipedia-org-9224 1276 5 : : : en-wikipedia-org-9224 1276 6 581–88 581–88 CD en-wikipedia-org-9224 1276 7 . . . en-wikipedia-org-9224 1277 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 1277 2 / / SYM en-wikipedia-org-9224 1277 3 j.tim.2005.09.005 j.tim.2005.09.005 NNP en-wikipedia-org-9224 1277 4 . . . en-wikipedia-org-9224 1278 1 PMID PMID NNP en-wikipedia-org-9224 1278 2   _SP en-wikipedia-org-9224 1278 3 16216510 16216510 CD en-wikipedia-org-9224 1278 4 . . . en-wikipedia-org-9224 1279 1 ^ ^ NNP en-wikipedia-org-9224 1279 2 Winstanley Winstanley NNP en-wikipedia-org-9224 1279 3 C C NNP en-wikipedia-org-9224 1279 4 , , , en-wikipedia-org-9224 1279 5 Hart Hart NNP en-wikipedia-org-9224 1279 6 CA CA NNP en-wikipedia-org-9224 1279 7 ( ( -LRB- en-wikipedia-org-9224 1279 8 February February NNP en-wikipedia-org-9224 1279 9 2001 2001 CD en-wikipedia-org-9224 1279 10 ) ) -RRB- en-wikipedia-org-9224 1279 11 . . . en-wikipedia-org-9224 1280 1 " " `` en-wikipedia-org-9224 1280 2 Type Type NNP en-wikipedia-org-9224 1280 3 III iii CD en-wikipedia-org-9224 1280 4 secretion secretion NN en-wikipedia-org-9224 1280 5 systems system NNS en-wikipedia-org-9224 1280 6 and and CC en-wikipedia-org-9224 1280 7 pathogenicity pathogenicity NN en-wikipedia-org-9224 1280 8 islands island NNS en-wikipedia-org-9224 1280 9 " " '' en-wikipedia-org-9224 1280 10 . . . en-wikipedia-org-9224 1281 1 Journal Journal NNP en-wikipedia-org-9224 1281 2 of of IN en-wikipedia-org-9224 1281 3 Medical Medical NNP en-wikipedia-org-9224 1281 4 Microbiology Microbiology NNP en-wikipedia-org-9224 1281 5 . . . en-wikipedia-org-9224 1282 1 50 50 CD en-wikipedia-org-9224 1282 2 ( ( -LRB- en-wikipedia-org-9224 1282 3 2 2 CD en-wikipedia-org-9224 1282 4 ) ) -RRB- en-wikipedia-org-9224 1282 5 : : : en-wikipedia-org-9224 1282 6 116–26 116–26 CD en-wikipedia-org-9224 1282 7 . . . en-wikipedia-org-9224 1283 1 doi:10.1099/0022 doi:10.1099/0022 NNP en-wikipedia-org-9224 1283 2 - - HYPH en-wikipedia-org-9224 1283 3 1317 1317 CD en-wikipedia-org-9224 1283 4 - - HYPH en-wikipedia-org-9224 1283 5 50 50 CD en-wikipedia-org-9224 1283 6 - - HYPH en-wikipedia-org-9224 1283 7 2 2 CD en-wikipedia-org-9224 1283 8 - - HYPH en-wikipedia-org-9224 1283 9 116 116 CD en-wikipedia-org-9224 1283 10 . . . en-wikipedia-org-9224 1284 1 PMID PMID NNP en-wikipedia-org-9224 1284 2   _SP en-wikipedia-org-9224 1284 3 11211218 11211218 CD en-wikipedia-org-9224 1284 4 . . . en-wikipedia-org-9224 1285 1 ^ ^ NFP en-wikipedia-org-9224 1285 2 Finlay Finlay NNP en-wikipedia-org-9224 1285 3 BB BB NNP en-wikipedia-org-9224 1285 4 , , , en-wikipedia-org-9224 1285 5 Falkow Falkow NNP en-wikipedia-org-9224 1285 6 S S NNP en-wikipedia-org-9224 1285 7 ( ( -LRB- en-wikipedia-org-9224 1285 8 June June NNP en-wikipedia-org-9224 1285 9 1997 1997 CD en-wikipedia-org-9224 1285 10 ) ) -RRB- en-wikipedia-org-9224 1285 11 . . . en-wikipedia-org-9224 1286 1 " " `` en-wikipedia-org-9224 1286 2 Common common JJ en-wikipedia-org-9224 1286 3 themes theme NNS en-wikipedia-org-9224 1286 4 in in IN en-wikipedia-org-9224 1286 5 microbial microbial JJ en-wikipedia-org-9224 1286 6 pathogenicity pathogenicity NN en-wikipedia-org-9224 1286 7 revisited revisit VBN en-wikipedia-org-9224 1286 8 " " '' en-wikipedia-org-9224 1286 9 . . . en-wikipedia-org-9224 1287 1 Microbiology Microbiology NNP en-wikipedia-org-9224 1287 2 and and CC en-wikipedia-org-9224 1287 3 Molecular Molecular NNP en-wikipedia-org-9224 1287 4 Biology Biology NNP en-wikipedia-org-9224 1287 5 Reviews Reviews NNPS en-wikipedia-org-9224 1287 6 . . . en-wikipedia-org-9224 1288 1 61 61 CD en-wikipedia-org-9224 1288 2 ( ( -LRB- en-wikipedia-org-9224 1288 3 2 2 CD en-wikipedia-org-9224 1288 4 ) ) -RRB- en-wikipedia-org-9224 1288 5 : : : en-wikipedia-org-9224 1288 6 136–69 136–69 CD en-wikipedia-org-9224 1288 7 . . . en-wikipedia-org-9224 1289 1 doi:10.1128/.61.2.136 doi:10.1128/.61.2.136 NNS en-wikipedia-org-9224 1289 2 - - HYPH en-wikipedia-org-9224 1289 3 169.1997 169.1997 CD en-wikipedia-org-9224 1289 4 . . . en-wikipedia-org-9224 1290 1 PMC PMC NNP en-wikipedia-org-9224 1290 2   _SP en-wikipedia-org-9224 1290 3 232605 232605 CD en-wikipedia-org-9224 1290 4 . . . en-wikipedia-org-9224 1291 1 PMID PMID NNP en-wikipedia-org-9224 1291 2   _SP en-wikipedia-org-9224 1291 3 9184008 9184008 CD en-wikipedia-org-9224 1291 4 . . . en-wikipedia-org-9224 1292 1 ^ ^ NNP en-wikipedia-org-9224 1292 2 Kobayashi Kobayashi NNP en-wikipedia-org-9224 1292 3 H H NNP en-wikipedia-org-9224 1292 4 ( ( -LRB- en-wikipedia-org-9224 1292 5 2005 2005 CD en-wikipedia-org-9224 1292 6 ) ) -RRB- en-wikipedia-org-9224 1292 7 . . . en-wikipedia-org-9224 1293 1 " " `` en-wikipedia-org-9224 1293 2 Airway airway NN en-wikipedia-org-9224 1293 3 biofilms biofilm NNS en-wikipedia-org-9224 1293 4 : : : en-wikipedia-org-9224 1293 5 implications implication NNS en-wikipedia-org-9224 1293 6 for for IN en-wikipedia-org-9224 1293 7 pathogenesis pathogenesis NN en-wikipedia-org-9224 1293 8 and and CC en-wikipedia-org-9224 1293 9 therapy therapy NN en-wikipedia-org-9224 1293 10 of of IN en-wikipedia-org-9224 1293 11 respiratory respiratory JJ en-wikipedia-org-9224 1293 12 tract tract NN en-wikipedia-org-9224 1293 13 infections infection NNS en-wikipedia-org-9224 1293 14 " " '' en-wikipedia-org-9224 1293 15 . . . en-wikipedia-org-9224 1294 1 Treatments treatment NNS en-wikipedia-org-9224 1294 2 in in IN en-wikipedia-org-9224 1294 3 Respiratory Respiratory NNP en-wikipedia-org-9224 1294 4 Medicine Medicine NNP en-wikipedia-org-9224 1294 5 . . . en-wikipedia-org-9224 1295 1 4 4 CD en-wikipedia-org-9224 1295 2 ( ( -LRB- en-wikipedia-org-9224 1295 3 4 4 CD en-wikipedia-org-9224 1295 4 ) ) -RRB- en-wikipedia-org-9224 1295 5 : : : en-wikipedia-org-9224 1295 6 241–53 241–53 CD en-wikipedia-org-9224 1295 7 . . . en-wikipedia-org-9224 1296 1 doi:10.2165/00151829 doi:10.2165/00151829 NNP en-wikipedia-org-9224 1296 2 - - HYPH en-wikipedia-org-9224 1296 3 200504040 200504040 CD en-wikipedia-org-9224 1296 4 - - HYPH en-wikipedia-org-9224 1296 5 00003 00003 CD en-wikipedia-org-9224 1296 6 . . . en-wikipedia-org-9224 1297 1 PMID PMID NNP en-wikipedia-org-9224 1297 2   _SP en-wikipedia-org-9224 1297 3 16086598 16086598 CD en-wikipedia-org-9224 1297 4 . . . en-wikipedia-org-9224 1298 1 S2CID S2CID NNS en-wikipedia-org-9224 1298 2   _SP en-wikipedia-org-9224 1298 3 31788349 31788349 CD en-wikipedia-org-9224 1298 4 . . . en-wikipedia-org-9224 1299 1 ^ ^ NN en-wikipedia-org-9224 1299 2 Housden Housden NNP en-wikipedia-org-9224 1299 3 NG NG NNP en-wikipedia-org-9224 1299 4 , , , en-wikipedia-org-9224 1299 5 Harrison Harrison NNP en-wikipedia-org-9224 1299 6 S S NNP en-wikipedia-org-9224 1299 7 , , , en-wikipedia-org-9224 1299 8 Roberts Roberts NNP en-wikipedia-org-9224 1299 9 SE SE NNP en-wikipedia-org-9224 1299 10 , , , en-wikipedia-org-9224 1299 11 Beckingham Beckingham NNP en-wikipedia-org-9224 1299 12 JA JA NNP en-wikipedia-org-9224 1299 13 , , , en-wikipedia-org-9224 1299 14 Graille Graille NNP en-wikipedia-org-9224 1299 15 M M NNP en-wikipedia-org-9224 1299 16 , , , en-wikipedia-org-9224 1299 17 Stura Stura NNP en-wikipedia-org-9224 1299 18 E E NNP en-wikipedia-org-9224 1299 19 , , , en-wikipedia-org-9224 1299 20 Gore Gore NNP en-wikipedia-org-9224 1299 21 MG MG NNP en-wikipedia-org-9224 1299 22 ( ( -LRB- en-wikipedia-org-9224 1299 23 June June NNP en-wikipedia-org-9224 1299 24 2003 2003 CD en-wikipedia-org-9224 1299 25 ) ) -RRB- en-wikipedia-org-9224 1299 26 . . . en-wikipedia-org-9224 1300 1 " " `` en-wikipedia-org-9224 1300 2 Immunoglobulin Immunoglobulin NNP en-wikipedia-org-9224 1300 3 - - HYPH en-wikipedia-org-9224 1300 4 binding bind VBG en-wikipedia-org-9224 1300 5 domains domain NNS en-wikipedia-org-9224 1300 6 : : : en-wikipedia-org-9224 1300 7 Protein protein NN en-wikipedia-org-9224 1300 8 L L NNP en-wikipedia-org-9224 1300 9 from from IN en-wikipedia-org-9224 1300 10 Peptostreptococcus Peptostreptococcus NNP en-wikipedia-org-9224 1300 11 magnus magnus NN en-wikipedia-org-9224 1300 12 " " '' en-wikipedia-org-9224 1300 13 . . . en-wikipedia-org-9224 1301 1 Biochemical Biochemical NNP en-wikipedia-org-9224 1301 2 Society Society NNP en-wikipedia-org-9224 1301 3 Transactions Transactions NNPS en-wikipedia-org-9224 1301 4 . . . en-wikipedia-org-9224 1302 1 31 31 CD en-wikipedia-org-9224 1302 2 ( ( -LRB- en-wikipedia-org-9224 1302 3 Pt Pt NNP en-wikipedia-org-9224 1302 4 3 3 CD en-wikipedia-org-9224 1302 5 ) ) -RRB- en-wikipedia-org-9224 1302 6 : : : en-wikipedia-org-9224 1302 7 716–18 716–18 CD en-wikipedia-org-9224 1302 8 . . . en-wikipedia-org-9224 1303 1 doi:10.1042 doi:10.1042 LS en-wikipedia-org-9224 1303 2 / / SYM en-wikipedia-org-9224 1303 3 BST0310716 BST0310716 NNP en-wikipedia-org-9224 1303 4 . . . en-wikipedia-org-9224 1304 1 PMID PMID NNP en-wikipedia-org-9224 1304 2   _SP en-wikipedia-org-9224 1304 3 12773190 12773190 CD en-wikipedia-org-9224 1304 4 . . . en-wikipedia-org-9224 1305 1 S2CID S2CID NNS en-wikipedia-org-9224 1305 2   _SP en-wikipedia-org-9224 1305 3 10322322 10322322 CD en-wikipedia-org-9224 1305 4 . . . en-wikipedia-org-9224 1306 1 ^ ^ NFP en-wikipedia-org-9224 1306 2 Burton Burton NNP en-wikipedia-org-9224 1306 3 DR DR NNP en-wikipedia-org-9224 1306 4 , , , en-wikipedia-org-9224 1306 5 Stanfield Stanfield NNP en-wikipedia-org-9224 1306 6 RL RL NNP en-wikipedia-org-9224 1306 7 , , , en-wikipedia-org-9224 1306 8 Wilson Wilson NNP en-wikipedia-org-9224 1306 9 IA IA NNP en-wikipedia-org-9224 1306 10 ( ( -LRB- en-wikipedia-org-9224 1306 11 October October NNP en-wikipedia-org-9224 1306 12 2005 2005 CD en-wikipedia-org-9224 1306 13 ) ) -RRB- en-wikipedia-org-9224 1306 14 . . . en-wikipedia-org-9224 1307 1 " " `` en-wikipedia-org-9224 1307 2 Antibody Antibody NNP en-wikipedia-org-9224 1307 3 vs. vs. IN en-wikipedia-org-9224 1307 4 HIV HIV NNP en-wikipedia-org-9224 1307 5 in in IN en-wikipedia-org-9224 1307 6 a a DT en-wikipedia-org-9224 1307 7 clash clash NN en-wikipedia-org-9224 1307 8 of of IN en-wikipedia-org-9224 1307 9 evolutionary evolutionary JJ en-wikipedia-org-9224 1307 10 titans titan NNS en-wikipedia-org-9224 1307 11 " " '' en-wikipedia-org-9224 1307 12 . . . en-wikipedia-org-9224 1308 1 Proceedings proceeding NNS en-wikipedia-org-9224 1308 2 of of IN en-wikipedia-org-9224 1308 3 the the DT en-wikipedia-org-9224 1308 4 National National NNP en-wikipedia-org-9224 1308 5 Academy Academy NNP en-wikipedia-org-9224 1308 6 of of IN en-wikipedia-org-9224 1308 7 Sciences Sciences NNPS en-wikipedia-org-9224 1308 8 of of IN en-wikipedia-org-9224 1308 9 the the DT en-wikipedia-org-9224 1308 10 United United NNP en-wikipedia-org-9224 1308 11 States States NNP en-wikipedia-org-9224 1308 12 of of IN en-wikipedia-org-9224 1308 13 America America NNP en-wikipedia-org-9224 1308 14 . . . en-wikipedia-org-9224 1309 1 102 102 CD en-wikipedia-org-9224 1309 2 ( ( -LRB- en-wikipedia-org-9224 1309 3 42 42 CD en-wikipedia-org-9224 1309 4 ) ) -RRB- en-wikipedia-org-9224 1309 5 : : : en-wikipedia-org-9224 1309 6 14943–48 14943–48 LS en-wikipedia-org-9224 1309 7 . . . en-wikipedia-org-9224 1310 1 Bibcode:2005PNAS Bibcode:2005PNAS NFP en-wikipedia-org-9224 1310 2 .. .. NFP en-wikipedia-org-9224 1310 3 10214943B. 10214943b. CD en-wikipedia-org-9224 1311 1 doi:10.1073 doi:10.1073 NNP en-wikipedia-org-9224 1311 2 / / SYM en-wikipedia-org-9224 1311 3 pnas.0505126102 pnas.0505126102 XX en-wikipedia-org-9224 1311 4 . . . en-wikipedia-org-9224 1312 1 PMC PMC NNP en-wikipedia-org-9224 1312 2   _SP en-wikipedia-org-9224 1312 3 1257708 1257708 CD en-wikipedia-org-9224 1312 4 . . . en-wikipedia-org-9224 1313 1 PMID PMID NNP en-wikipedia-org-9224 1313 2   _SP en-wikipedia-org-9224 1313 3 16219699 16219699 CD en-wikipedia-org-9224 1313 4 . . . en-wikipedia-org-9224 1314 1 ^ ^ NNP en-wikipedia-org-9224 1314 2 Taylor Taylor NNP en-wikipedia-org-9224 1314 3 JE JE NNP en-wikipedia-org-9224 1314 4 , , , en-wikipedia-org-9224 1314 5 Rudenko Rudenko NNP en-wikipedia-org-9224 1314 6 G G NNP en-wikipedia-org-9224 1314 7 ( ( -LRB- en-wikipedia-org-9224 1314 8 November November NNP en-wikipedia-org-9224 1314 9 2006 2006 CD en-wikipedia-org-9224 1314 10 ) ) -RRB- en-wikipedia-org-9224 1314 11 . . . en-wikipedia-org-9224 1315 1 " " `` en-wikipedia-org-9224 1315 2 Switching switch VBG en-wikipedia-org-9224 1315 3 trypanosome trypanosome JJ en-wikipedia-org-9224 1315 4 coats coat NNS en-wikipedia-org-9224 1315 5 : : : en-wikipedia-org-9224 1315 6 what what WP en-wikipedia-org-9224 1315 7 's be VBZ en-wikipedia-org-9224 1315 8 in in IN en-wikipedia-org-9224 1315 9 the the DT en-wikipedia-org-9224 1315 10 wardrobe wardrobe NN en-wikipedia-org-9224 1315 11 ? ? . en-wikipedia-org-9224 1315 12 " " '' en-wikipedia-org-9224 1315 13 . . . en-wikipedia-org-9224 1316 1 Trends trend NNS en-wikipedia-org-9224 1316 2 in in IN en-wikipedia-org-9224 1316 3 Genetics Genetics NNP en-wikipedia-org-9224 1316 4 . . . en-wikipedia-org-9224 1317 1 22 22 CD en-wikipedia-org-9224 1317 2 ( ( -LRB- en-wikipedia-org-9224 1317 3 11 11 CD en-wikipedia-org-9224 1317 4 ) ) -RRB- en-wikipedia-org-9224 1317 5 : : : en-wikipedia-org-9224 1317 6 614–20 614–20 CD en-wikipedia-org-9224 1317 7 . . . en-wikipedia-org-9224 1318 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 1318 2 / / SYM en-wikipedia-org-9224 1318 3 j.tig.2006.08.003 j.tig.2006.08.003 NNP en-wikipedia-org-9224 1318 4 . . . en-wikipedia-org-9224 1319 1 PMID PMID NNP en-wikipedia-org-9224 1319 2   _SP en-wikipedia-org-9224 1319 3 16908087 16908087 CD en-wikipedia-org-9224 1319 4 . . . en-wikipedia-org-9224 1320 1 ^ ^ NFP en-wikipedia-org-9224 1320 2 Cantin Cantin NNP en-wikipedia-org-9224 1320 3 R R NNP en-wikipedia-org-9224 1320 4 , , , en-wikipedia-org-9224 1320 5 Méthot Méthot NNP en-wikipedia-org-9224 1320 6 S S NNP en-wikipedia-org-9224 1320 7 , , , en-wikipedia-org-9224 1320 8 Tremblay Tremblay NNP en-wikipedia-org-9224 1320 9 MJ MJ NNP en-wikipedia-org-9224 1320 10 ( ( -LRB- en-wikipedia-org-9224 1320 11 June June NNP en-wikipedia-org-9224 1320 12 2005 2005 CD en-wikipedia-org-9224 1320 13 ) ) -RRB- en-wikipedia-org-9224 1320 14 . . . en-wikipedia-org-9224 1321 1 " " `` en-wikipedia-org-9224 1321 2 Plunder plunder VB en-wikipedia-org-9224 1321 3 and and CC en-wikipedia-org-9224 1321 4 stowaways stowaway NNS en-wikipedia-org-9224 1321 5 : : : en-wikipedia-org-9224 1321 6 incorporation incorporation NN en-wikipedia-org-9224 1321 7 of of IN en-wikipedia-org-9224 1321 8 cellular cellular JJ en-wikipedia-org-9224 1321 9 proteins protein NNS en-wikipedia-org-9224 1321 10 by by IN en-wikipedia-org-9224 1321 11 enveloped envelop VBN en-wikipedia-org-9224 1321 12 viruses virus NNS en-wikipedia-org-9224 1321 13 " " '' en-wikipedia-org-9224 1321 14 . . . en-wikipedia-org-9224 1322 1 Journal Journal NNP en-wikipedia-org-9224 1322 2 of of IN en-wikipedia-org-9224 1322 3 Virology Virology NNP en-wikipedia-org-9224 1322 4 . . . en-wikipedia-org-9224 1323 1 79 79 CD en-wikipedia-org-9224 1323 2 ( ( -LRB- en-wikipedia-org-9224 1323 3 11 11 CD en-wikipedia-org-9224 1323 4 ) ) -RRB- en-wikipedia-org-9224 1323 5 : : : en-wikipedia-org-9224 1323 6 6577–87 6577–87 LS en-wikipedia-org-9224 1323 7 . . . en-wikipedia-org-9224 1324 1 doi:10.1128 doi:10.1128 NNP en-wikipedia-org-9224 1324 2 / / SYM en-wikipedia-org-9224 1324 3 JVI.79.11.6577 JVI.79.11.6577 NNP en-wikipedia-org-9224 1324 4 - - HYPH en-wikipedia-org-9224 1324 5 6587.2005 6587.2005 CD en-wikipedia-org-9224 1324 6 . . . en-wikipedia-org-9224 1325 1 PMC PMC NNP en-wikipedia-org-9224 1325 2   _SP en-wikipedia-org-9224 1325 3 1112128 1112128 CD en-wikipedia-org-9224 1325 4 . . . en-wikipedia-org-9224 1326 1 PMID PMID NNP en-wikipedia-org-9224 1326 2   _SP en-wikipedia-org-9224 1326 3 15890896 15890896 CD en-wikipedia-org-9224 1326 4 . . . en-wikipedia-org-9224 1327 1 ^ ^ NNP en-wikipedia-org-9224 1327 2 a a DT en-wikipedia-org-9224 1327 3 b b NNP en-wikipedia-org-9224 1327 4 " " `` en-wikipedia-org-9224 1327 5 The the DT en-wikipedia-org-9224 1327 6 Nobel Nobel NNP en-wikipedia-org-9224 1327 7 Prize Prize NNP en-wikipedia-org-9224 1327 8 in in IN en-wikipedia-org-9224 1327 9 Physiology Physiology NNP en-wikipedia-org-9224 1327 10 or or CC en-wikipedia-org-9224 1327 11 Medicine medicine NN en-wikipedia-org-9224 1327 12 1908 1908 CD en-wikipedia-org-9224 1327 13 " " '' en-wikipedia-org-9224 1327 14 . . . en-wikipedia-org-9224 1328 1 The the DT en-wikipedia-org-9224 1328 2 Nobel Nobel NNP en-wikipedia-org-9224 1328 3 Prize Prize NNP en-wikipedia-org-9224 1328 4 . . . en-wikipedia-org-9224 1329 1 Retrieved retrieve VBN en-wikipedia-org-9224 1329 2 8 8 CD en-wikipedia-org-9224 1329 3 January January NNP en-wikipedia-org-9224 1329 4 2007 2007 CD en-wikipedia-org-9224 1329 5 . . . en-wikipedia-org-9224 1330 1 ^ ^ NNP en-wikipedia-org-9224 1330 2 Retief Retief NNP en-wikipedia-org-9224 1330 3 FP FP NNP en-wikipedia-org-9224 1330 4 , , , en-wikipedia-org-9224 1330 5 Cilliers Cilliers NNP en-wikipedia-org-9224 1330 6 L L NNP en-wikipedia-org-9224 1330 7 ( ( -LRB- en-wikipedia-org-9224 1330 8 January January NNP en-wikipedia-org-9224 1330 9 1998 1998 CD en-wikipedia-org-9224 1330 10 ) ) -RRB- en-wikipedia-org-9224 1330 11 . . . en-wikipedia-org-9224 1331 1 " " `` en-wikipedia-org-9224 1331 2 The the DT en-wikipedia-org-9224 1331 3 epidemic epidemic NN en-wikipedia-org-9224 1331 4 of of IN en-wikipedia-org-9224 1331 5 Athens Athens NNP en-wikipedia-org-9224 1331 6 , , , en-wikipedia-org-9224 1331 7 430–426 430–426 CD en-wikipedia-org-9224 1331 8 BC BC NNP en-wikipedia-org-9224 1331 9 " " '' en-wikipedia-org-9224 1331 10 . . . en-wikipedia-org-9224 1332 1 South south JJ en-wikipedia-org-9224 1332 2 African African NNP en-wikipedia-org-9224 1332 3 Medical Medical NNP en-wikipedia-org-9224 1332 4 Journal Journal NNP en-wikipedia-org-9224 1332 5 = = SYM en-wikipedia-org-9224 1332 6 Suid Suid NNP en-wikipedia-org-9224 1332 7 - - HYPH en-wikipedia-org-9224 1332 8 Afrikaanse Afrikaanse NNP en-wikipedia-org-9224 1332 9 Tydskrif Tydskrif NNP en-wikipedia-org-9224 1332 10 vir vir NNP en-wikipedia-org-9224 1332 11 Geneeskunde Geneeskunde NNP en-wikipedia-org-9224 1332 12 . . . en-wikipedia-org-9224 1333 1 88 88 CD en-wikipedia-org-9224 1333 2 ( ( -LRB- en-wikipedia-org-9224 1333 3 1 1 CD en-wikipedia-org-9224 1333 4 ) ) -RRB- en-wikipedia-org-9224 1333 5 : : : en-wikipedia-org-9224 1333 6 50–53 50–53 CD en-wikipedia-org-9224 1333 7 . . . en-wikipedia-org-9224 1334 1 PMID PMID NNP en-wikipedia-org-9224 1334 2   _SP en-wikipedia-org-9224 1334 3 9539938 9539938 CD en-wikipedia-org-9224 1334 4 . . . en-wikipedia-org-9224 1335 1 ^ ^ NFP en-wikipedia-org-9224 1335 2 Ostoya Ostoya NNP en-wikipedia-org-9224 1335 3 P P NNP en-wikipedia-org-9224 1335 4 ( ( -LRB- en-wikipedia-org-9224 1335 5 1954 1954 CD en-wikipedia-org-9224 1335 6 ) ) -RRB- en-wikipedia-org-9224 1335 7 . . . en-wikipedia-org-9224 1336 1 " " `` en-wikipedia-org-9224 1336 2 Maupertuis Maupertuis NNP en-wikipedia-org-9224 1336 3 et et NNP en-wikipedia-org-9224 1336 4 la la NNP en-wikipedia-org-9224 1336 5 biologie biologie NNP en-wikipedia-org-9224 1336 6 " " '' en-wikipedia-org-9224 1336 7 . . . en-wikipedia-org-9224 1337 1 Revue Revue NNP en-wikipedia-org-9224 1337 2 d'histoire d'histoire NNP en-wikipedia-org-9224 1337 3 des des NNP en-wikipedia-org-9224 1337 4 sciences sciences NNPS en-wikipedia-org-9224 1337 5 et et FW en-wikipedia-org-9224 1337 6 de de FW en-wikipedia-org-9224 1337 7 leurs leurs NNP en-wikipedia-org-9224 1337 8 applications application NNS en-wikipedia-org-9224 1337 9 . . . en-wikipedia-org-9224 1338 1 7 7 CD en-wikipedia-org-9224 1338 2 ( ( -LRB- en-wikipedia-org-9224 1338 3 1 1 CD en-wikipedia-org-9224 1338 4 ) ) -RRB- en-wikipedia-org-9224 1338 5 : : : en-wikipedia-org-9224 1338 6 60–78 60–78 CD en-wikipedia-org-9224 1338 7 . . . en-wikipedia-org-9224 1339 1 doi:10.3406 doi:10.3406 NNP en-wikipedia-org-9224 1339 2 / / SYM en-wikipedia-org-9224 1339 3 rhs.1954.3379 rhs.1954.3379 JJ en-wikipedia-org-9224 1339 4 . . . en-wikipedia-org-9224 1340 1 ^ ^ NFP en-wikipedia-org-9224 1340 2 Doherty Doherty NNP en-wikipedia-org-9224 1340 3 M M NNP en-wikipedia-org-9224 1340 4 , , , en-wikipedia-org-9224 1340 5 Robertson Robertson NNP en-wikipedia-org-9224 1340 6 MJ MJ NNP en-wikipedia-org-9224 1340 7 ( ( -LRB- en-wikipedia-org-9224 1340 8 December December NNP en-wikipedia-org-9224 1340 9 2004 2004 CD en-wikipedia-org-9224 1340 10 ) ) -RRB- en-wikipedia-org-9224 1340 11 . . . en-wikipedia-org-9224 1341 1 " " `` en-wikipedia-org-9224 1341 2 Some some DT en-wikipedia-org-9224 1341 3 early early JJ en-wikipedia-org-9224 1341 4 Trends trend NNS en-wikipedia-org-9224 1341 5 in in IN en-wikipedia-org-9224 1341 6 Immunology Immunology NNP en-wikipedia-org-9224 1341 7 " " '' en-wikipedia-org-9224 1341 8 . . . en-wikipedia-org-9224 1342 1 Trends trend NNS en-wikipedia-org-9224 1342 2 in in IN en-wikipedia-org-9224 1342 3 Immunology immunology NN en-wikipedia-org-9224 1342 4 . . . en-wikipedia-org-9224 1343 1 25 25 CD en-wikipedia-org-9224 1343 2 ( ( -LRB- en-wikipedia-org-9224 1343 3 12 12 CD en-wikipedia-org-9224 1343 4 ) ) -RRB- en-wikipedia-org-9224 1343 5 : : : en-wikipedia-org-9224 1343 6 623–31 623–31 CD en-wikipedia-org-9224 1343 7 . . . en-wikipedia-org-9224 1344 1 doi:10.1016 doi:10.1016 NNP en-wikipedia-org-9224 1344 2 / / SYM en-wikipedia-org-9224 1344 3 j.it.2004.10.008 j.it.2004.10.008 NNP en-wikipedia-org-9224 1344 4 . . . en-wikipedia-org-9224 1345 1 PMID PMID NNP en-wikipedia-org-9224 1345 2   _SP en-wikipedia-org-9224 1345 3 15530829 15530829 CD en-wikipedia-org-9224 1345 4 . . . en-wikipedia-org-9224 1346 1 ^ ^ NNP en-wikipedia-org-9224 1346 2 Silverstein Silverstein NNP en-wikipedia-org-9224 1346 3 1989 1989 CD en-wikipedia-org-9224 1346 4 , , , en-wikipedia-org-9224 1346 5 p. p. NN en-wikipedia-org-9224 1346 6   _SP en-wikipedia-org-9224 1346 7 6 6 CD en-wikipedia-org-9224 1346 8 . . . en-wikipedia-org-9224 1347 1 ^ ^ NNP en-wikipedia-org-9224 1347 2 Silverstein Silverstein NNP en-wikipedia-org-9224 1347 3 1989 1989 CD en-wikipedia-org-9224 1347 4 , , , en-wikipedia-org-9224 1347 5 p. p. NN en-wikipedia-org-9224 1347 6   _SP en-wikipedia-org-9224 1347 7 7 7 CD en-wikipedia-org-9224 1347 8 . . . en-wikipedia-org-9224 1348 1 ^ ^ NNP en-wikipedia-org-9224 1348 2 Plotkin Plotkin NNP en-wikipedia-org-9224 1348 3 SA SA NNP en-wikipedia-org-9224 1348 4 ( ( -LRB- en-wikipedia-org-9224 1348 5 April April NNP en-wikipedia-org-9224 1348 6 2005 2005 CD en-wikipedia-org-9224 1348 7 ) ) -RRB- en-wikipedia-org-9224 1348 8 . . . en-wikipedia-org-9224 1349 1 " " `` en-wikipedia-org-9224 1349 2 Vaccines vaccine NNS en-wikipedia-org-9224 1349 3 : : : en-wikipedia-org-9224 1349 4 past past JJ en-wikipedia-org-9224 1349 5 , , , en-wikipedia-org-9224 1349 6 present present JJ en-wikipedia-org-9224 1349 7 and and CC en-wikipedia-org-9224 1349 8 future future JJ en-wikipedia-org-9224 1349 9 " " '' en-wikipedia-org-9224 1349 10 . . . en-wikipedia-org-9224 1350 1 Nature Nature NNP en-wikipedia-org-9224 1350 2 Medicine Medicine NNP en-wikipedia-org-9224 1350 3 . . . en-wikipedia-org-9224 1351 1 11 11 CD en-wikipedia-org-9224 1351 2 ( ( -LRB- en-wikipedia-org-9224 1351 3 4 4 CD en-wikipedia-org-9224 1351 4 Suppl Suppl NNP en-wikipedia-org-9224 1351 5 ) ) -RRB- en-wikipedia-org-9224 1351 6 : : : en-wikipedia-org-9224 1351 7 S5–11 s5–11 CD en-wikipedia-org-9224 1351 8 . . . en-wikipedia-org-9224 1352 1 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 1352 2 / / SYM en-wikipedia-org-9224 1352 3 nm1209 nm1209 NNP en-wikipedia-org-9224 1352 4 . . . en-wikipedia-org-9224 1353 1 PMC PMC NNP en-wikipedia-org-9224 1353 2   _SP en-wikipedia-org-9224 1353 3 7095920 7095920 CD en-wikipedia-org-9224 1353 4 . . . en-wikipedia-org-9224 1354 1 PMID PMID NNP en-wikipedia-org-9224 1354 2   _SP en-wikipedia-org-9224 1354 3 15812490 15812490 CD en-wikipedia-org-9224 1354 4 . . . en-wikipedia-org-9224 1355 1 ^ ^ NFP en-wikipedia-org-9224 1355 2 The the DT en-wikipedia-org-9224 1355 3 Nobel Nobel NNP en-wikipedia-org-9224 1355 4 Prize Prize NNP en-wikipedia-org-9224 1355 5 in in IN en-wikipedia-org-9224 1355 6 Physiology Physiology NNP en-wikipedia-org-9224 1355 7 or or CC en-wikipedia-org-9224 1355 8 Medicine Medicine NNP en-wikipedia-org-9224 1355 9 1905 1905 CD en-wikipedia-org-9224 1355 10 Nobelprize.org Nobelprize.org NNP en-wikipedia-org-9224 1355 11 Retrieved Retrieved NNP en-wikipedia-org-9224 1355 12 on on IN en-wikipedia-org-9224 1355 13 8 8 CD en-wikipedia-org-9224 1355 14 January January NNP en-wikipedia-org-9224 1355 15 2009 2009 CD en-wikipedia-org-9224 1355 16 . . . en-wikipedia-org-9224 1356 1 ^ ^ NFP en-wikipedia-org-9224 1356 2 Major Major NNP en-wikipedia-org-9224 1356 3 Walter Walter NNP en-wikipedia-org-9224 1356 4 Reed Reed NNP en-wikipedia-org-9224 1356 5 , , , en-wikipedia-org-9224 1356 6 Medical Medical NNP en-wikipedia-org-9224 1356 7 Corps Corps NNP en-wikipedia-org-9224 1356 8 , , , en-wikipedia-org-9224 1356 9 U.S. U.S. NNP en-wikipedia-org-9224 1356 10 Army Army NNP en-wikipedia-org-9224 1356 11 Walter Walter NNP en-wikipedia-org-9224 1356 12 Reed Reed NNP en-wikipedia-org-9224 1356 13 Army Army NNP en-wikipedia-org-9224 1356 14 Medical Medical NNP en-wikipedia-org-9224 1356 15 Center Center NNP en-wikipedia-org-9224 1356 16 . . . en-wikipedia-org-9224 1357 1 Retrieved retrieve VBN en-wikipedia-org-9224 1357 2 on on IN en-wikipedia-org-9224 1357 3 8 8 CD en-wikipedia-org-9224 1357 4 January January NNP en-wikipedia-org-9224 1357 5 2007 2007 CD en-wikipedia-org-9224 1357 6 . . . en-wikipedia-org-9224 1358 1 ^ ^ NNP en-wikipedia-org-9224 1358 2 Metchnikoff Metchnikoff NNP en-wikipedia-org-9224 1358 3 E E NNP en-wikipedia-org-9224 1358 4 ( ( -LRB- en-wikipedia-org-9224 1358 5 1905 1905 CD en-wikipedia-org-9224 1358 6 ) ) -RRB- en-wikipedia-org-9224 1358 7 . . . en-wikipedia-org-9224 1359 1 Immunity immunity NN en-wikipedia-org-9224 1359 2 in in IN en-wikipedia-org-9224 1359 3 Infective Infective NNP en-wikipedia-org-9224 1359 4 Diseases Diseases NNP en-wikipedia-org-9224 1359 5 ( ( -LRB- en-wikipedia-org-9224 1359 6 Full Full NNP en-wikipedia-org-9224 1359 7 Text Text NNP en-wikipedia-org-9224 1359 8 Version version NN en-wikipedia-org-9224 1359 9 : : : en-wikipedia-org-9224 1359 10 Internet Internet NNP en-wikipedia-org-9224 1359 11 Archive Archive NNP en-wikipedia-org-9224 1359 12 ) ) -RRB- en-wikipedia-org-9224 1359 13 . . . en-wikipedia-org-9224 1360 1 Translated translate VBN en-wikipedia-org-9224 1360 2 by by IN en-wikipedia-org-9224 1360 3 Binnie Binnie NNP en-wikipedia-org-9224 1360 4 FG FG NNP en-wikipedia-org-9224 1360 5 . . . en-wikipedia-org-9224 1361 1 Cambridge Cambridge NNP en-wikipedia-org-9224 1361 2 University University NNP en-wikipedia-org-9224 1361 3 Press Press NNP en-wikipedia-org-9224 1361 4 . . . en-wikipedia-org-9224 1362 1 LCCN LCCN NNP en-wikipedia-org-9224 1362 2   _SP en-wikipedia-org-9224 1362 3 68025143 68025143 CD en-wikipedia-org-9224 1362 4 . . . en-wikipedia-org-9224 1362 5 history history NN en-wikipedia-org-9224 1362 6 of of IN en-wikipedia-org-9224 1362 7 humoral humoral JJ en-wikipedia-org-9224 1362 8 immunity immunity NN en-wikipedia-org-9224 1362 9 . . . en-wikipedia-org-9224 1363 1 ^ ^ FW en-wikipedia-org-9224 1363 2 " " `` en-wikipedia-org-9224 1363 3 Niels niel VBZ en-wikipedia-org-9224 1363 4 K. K. NNP en-wikipedia-org-9224 1363 5 Jerne Jerne NNP en-wikipedia-org-9224 1363 6 " " '' en-wikipedia-org-9224 1363 7 . . . en-wikipedia-org-9224 1364 1 The the DT en-wikipedia-org-9224 1364 2 Nobel Nobel NNP en-wikipedia-org-9224 1364 3 Prize Prize NNP en-wikipedia-org-9224 1364 4 . . . en-wikipedia-org-9224 1365 1 Retrieved retrieve VBN en-wikipedia-org-9224 1365 2 27 27 CD en-wikipedia-org-9224 1365 3 November November NNP en-wikipedia-org-9224 1365 4 2020 2020 CD en-wikipedia-org-9224 1365 5 . . . en-wikipedia-org-9224 1366 1 ^ ^ NN en-wikipedia-org-9224 1366 2 Yewdell Yewdell NNP en-wikipedia-org-9224 1366 3 J J NNP en-wikipedia-org-9224 1366 4 ( ( -LRB- en-wikipedia-org-9224 1366 5 4 4 CD en-wikipedia-org-9224 1366 6 October October NNP en-wikipedia-org-9224 1366 7 2003 2003 CD en-wikipedia-org-9224 1366 8 ) ) -RRB- en-wikipedia-org-9224 1366 9 . . . en-wikipedia-org-9224 1367 1 " " `` en-wikipedia-org-9224 1367 2 He -PRON- PRP en-wikipedia-org-9224 1367 3 put put VBD en-wikipedia-org-9224 1367 4 the the DT en-wikipedia-org-9224 1367 5 I -PRON- PRP en-wikipedia-org-9224 1367 6 d d NN en-wikipedia-org-9224 1367 7 in in IN en-wikipedia-org-9224 1367 8 Idiotype Idiotype NNP en-wikipedia-org-9224 1367 9 " " '' en-wikipedia-org-9224 1367 10 . . . en-wikipedia-org-9224 1368 1 EMBO EMBO NNP en-wikipedia-org-9224 1368 2 Reports report NNS en-wikipedia-org-9224 1368 3 ( ( -LRB- en-wikipedia-org-9224 1368 4 Book Book NNP en-wikipedia-org-9224 1368 5 review review NN en-wikipedia-org-9224 1368 6 ) ) -RRB- en-wikipedia-org-9224 1368 7 . . . en-wikipedia-org-9224 1369 1 4 4 CD en-wikipedia-org-9224 1369 2 ( ( -LRB- en-wikipedia-org-9224 1369 3 10 10 CD en-wikipedia-org-9224 1369 4 ) ) -RRB- en-wikipedia-org-9224 1369 5 : : : en-wikipedia-org-9224 1369 6 931 931 CD en-wikipedia-org-9224 1369 7 . . . en-wikipedia-org-9224 1369 8 doi:10.1038 doi:10.1038 NNP en-wikipedia-org-9224 1369 9 / / SYM en-wikipedia-org-9224 1369 10 sj.embor.embor951 sj.embor.embor951 NNP en-wikipedia-org-9224 1369 11 . . . en-wikipedia-org-9224 1370 1 PMC PMC NNP en-wikipedia-org-9224 1370 2   _SP en-wikipedia-org-9224 1370 3 1326409 1326409 CD en-wikipedia-org-9224 1370 4 . . . en-wikipedia-org-9224 1371 1 Bibliography[edit bibliography[edit LS en-wikipedia-org-9224 1371 2 ] ] -RRB- en-wikipedia-org-9224 1371 3 Alberts Alberts NNP en-wikipedia-org-9224 1371 4 B B NNP en-wikipedia-org-9224 1371 5 , , , en-wikipedia-org-9224 1371 6 Johnson Johnson NNP en-wikipedia-org-9224 1371 7 A A NNP en-wikipedia-org-9224 1371 8 , , , en-wikipedia-org-9224 1371 9 Lewis Lewis NNP en-wikipedia-org-9224 1371 10 J J NNP en-wikipedia-org-9224 1371 11 , , , en-wikipedia-org-9224 1371 12 Raff Raff NNP en-wikipedia-org-9224 1371 13 M M NNP en-wikipedia-org-9224 1371 14 , , , en-wikipedia-org-9224 1371 15 Roberts Roberts NNP en-wikipedia-org-9224 1371 16 K K NNP en-wikipedia-org-9224 1371 17 , , , en-wikipedia-org-9224 1371 18 Walters Walters NNP en-wikipedia-org-9224 1371 19 P P NNP en-wikipedia-org-9224 1371 20 ( ( -LRB- en-wikipedia-org-9224 1371 21 2002 2002 CD en-wikipedia-org-9224 1371 22 ) ) -RRB- en-wikipedia-org-9224 1371 23 . . . en-wikipedia-org-9224 1372 1 Molecular Molecular NNP en-wikipedia-org-9224 1372 2 Biology Biology NNP en-wikipedia-org-9224 1372 3 of of IN en-wikipedia-org-9224 1372 4 the the DT en-wikipedia-org-9224 1372 5 Cell Cell NNP en-wikipedia-org-9224 1372 6 ( ( -LRB- en-wikipedia-org-9224 1372 7 Fourth Fourth NNP en-wikipedia-org-9224 1372 8 ed ed NNP en-wikipedia-org-9224 1372 9 . . . en-wikipedia-org-9224 1372 10 ) ) -RRB- en-wikipedia-org-9224 1372 11 . . . en-wikipedia-org-9224 1373 1 New New NNP en-wikipedia-org-9224 1373 2 York York NNP en-wikipedia-org-9224 1373 3 and and CC en-wikipedia-org-9224 1373 4 London London NNP en-wikipedia-org-9224 1373 5 : : : en-wikipedia-org-9224 1373 6 Garland Garland NNP en-wikipedia-org-9224 1373 7 Science Science NNP en-wikipedia-org-9224 1373 8 . . . en-wikipedia-org-9224 1374 1 ISBN ISBN NNP en-wikipedia-org-9224 1374 2   _SP en-wikipedia-org-9224 1374 3 978 978 CD en-wikipedia-org-9224 1374 4 - - HYPH en-wikipedia-org-9224 1374 5 0 0 CD en-wikipedia-org-9224 1374 6 - - HYPH en-wikipedia-org-9224 1374 7 8153 8153 CD en-wikipedia-org-9224 1374 8 - - HYPH en-wikipedia-org-9224 1374 9 3218 3218 CD en-wikipedia-org-9224 1374 10 - - SYM en-wikipedia-org-9224 1374 11 3 3 CD en-wikipedia-org-9224 1374 12 . . . en-wikipedia-org-9224 1375 1 Iriti Iriti NNP en-wikipedia-org-9224 1375 2 , , , en-wikipedia-org-9224 1375 3 Marcello Marcello NNP en-wikipedia-org-9224 1375 4 ( ( -LRB- en-wikipedia-org-9224 1375 5 2019 2019 CD en-wikipedia-org-9224 1375 6 ) ) -RRB- en-wikipedia-org-9224 1375 7 . . . en-wikipedia-org-9224 1376 1 Plant Plant NNP en-wikipedia-org-9224 1376 2 Innate Innate NNP en-wikipedia-org-9224 1376 3 Immunity immunity NN en-wikipedia-org-9224 1376 4 2.0 2.0 CD en-wikipedia-org-9224 1376 5 . . . en-wikipedia-org-9224 1377 1 Basel Basel NNP en-wikipedia-org-9224 1377 2 : : : en-wikipedia-org-9224 1377 3 MDPI MDPI NNP en-wikipedia-org-9224 1377 4 . . . en-wikipedia-org-9224 1378 1 doi:10.3390 doi:10.3390 NNP en-wikipedia-org-9224 1378 2 / / SYM en-wikipedia-org-9224 1378 3 books978 books978 NNP en-wikipedia-org-9224 1378 4 - - HYPH en-wikipedia-org-9224 1378 5 3 3 CD en-wikipedia-org-9224 1378 6 - - HYPH en-wikipedia-org-9224 1378 7 03897 03897 CD en-wikipedia-org-9224 1378 8 - - HYPH en-wikipedia-org-9224 1378 9 581 581 CD en-wikipedia-org-9224 1378 10 - - SYM en-wikipedia-org-9224 1378 11 6 6 CD en-wikipedia-org-9224 1378 12 . . . en-wikipedia-org-9224 1379 1 ISBN ISBN NNP en-wikipedia-org-9224 1379 2   _SP en-wikipedia-org-9224 1379 3 978 978 CD en-wikipedia-org-9224 1379 4 - - HYPH en-wikipedia-org-9224 1379 5 3 3 CD en-wikipedia-org-9224 1379 6 - - HYPH en-wikipedia-org-9224 1379 7 03897 03897 CD en-wikipedia-org-9224 1379 8 - - HYPH en-wikipedia-org-9224 1379 9 580 580 CD en-wikipedia-org-9224 1379 10 - - SYM en-wikipedia-org-9224 1379 11 9 9 CD en-wikipedia-org-9224 1379 12 . . . en-wikipedia-org-9224 1380 1 OCLC oclc NN en-wikipedia-org-9224 1380 2   _SP en-wikipedia-org-9224 1380 3 1105775088 1105775088 CD en-wikipedia-org-9224 1380 4 . . . en-wikipedia-org-9224 1381 1 Janeway Janeway NNP en-wikipedia-org-9224 1381 2 CA CA NNP en-wikipedia-org-9224 1381 3 , , , en-wikipedia-org-9224 1381 4 Travers Travers NNP en-wikipedia-org-9224 1381 5 P P NNP en-wikipedia-org-9224 1381 6 , , , en-wikipedia-org-9224 1381 7 Walport Walport NNP en-wikipedia-org-9224 1381 8 M M NNP en-wikipedia-org-9224 1381 9 ( ( -LRB- en-wikipedia-org-9224 1381 10 2001 2001 CD en-wikipedia-org-9224 1381 11 ) ) -RRB- en-wikipedia-org-9224 1381 12 . . . en-wikipedia-org-9224 1382 1 Immunobiology immunobiology NN en-wikipedia-org-9224 1382 2 ( ( -LRB- en-wikipedia-org-9224 1382 3 5th 5th JJ en-wikipedia-org-9224 1382 4 ed ed NNP en-wikipedia-org-9224 1382 5 . . . en-wikipedia-org-9224 1382 6 ) ) -RRB- en-wikipedia-org-9224 1382 7 . . . en-wikipedia-org-9224 1383 1 Garland Garland NNP en-wikipedia-org-9224 1383 2 Science Science NNP en-wikipedia-org-9224 1383 3 . . . en-wikipedia-org-9224 1384 1 Janeway Janeway NNP en-wikipedia-org-9224 1384 2 CA CA NNP en-wikipedia-org-9224 1384 3 ( ( -LRB- en-wikipedia-org-9224 1384 4 2005 2005 CD en-wikipedia-org-9224 1384 5 ) ) -RRB- en-wikipedia-org-9224 1384 6 . . . en-wikipedia-org-9224 1385 1 Immunobiology immunobiology NN en-wikipedia-org-9224 1385 2 ( ( -LRB- en-wikipedia-org-9224 1385 3 6th 6th NNP en-wikipedia-org-9224 1385 4 ed ed NNP en-wikipedia-org-9224 1385 5 . . . en-wikipedia-org-9224 1385 6 ) ) -RRB- en-wikipedia-org-9224 1385 7 . . . en-wikipedia-org-9224 1386 1 Garland Garland NNP en-wikipedia-org-9224 1386 2 Science Science NNP en-wikipedia-org-9224 1386 3 . . . en-wikipedia-org-9224 1387 1 ISBN ISBN NNP en-wikipedia-org-9224 1387 2   _SP en-wikipedia-org-9224 1387 3 0 0 CD en-wikipedia-org-9224 1387 4 - - HYPH en-wikipedia-org-9224 1387 5 443 443 CD en-wikipedia-org-9224 1387 6 - - HYPH en-wikipedia-org-9224 1387 7 07310 07310 CD en-wikipedia-org-9224 1387 8 - - SYM en-wikipedia-org-9224 1387 9 4 4 CD en-wikipedia-org-9224 1387 10 . . . en-wikipedia-org-9224 1388 1 Krishnaswamy Krishnaswamy NNP en-wikipedia-org-9224 1388 2 G G NNP en-wikipedia-org-9224 1388 3 , , , en-wikipedia-org-9224 1388 4 Ajitawi Ajitawi NNP en-wikipedia-org-9224 1388 5 O O NNP en-wikipedia-org-9224 1388 6 , , , en-wikipedia-org-9224 1388 7 Chi Chi NNP en-wikipedia-org-9224 1388 8 DS DS NNP en-wikipedia-org-9224 1388 9 ( ( -LRB- en-wikipedia-org-9224 1388 10 2006 2006 CD en-wikipedia-org-9224 1388 11 ) ) -RRB- en-wikipedia-org-9224 1388 12 . . . en-wikipedia-org-9224 1389 1 " " `` en-wikipedia-org-9224 1389 2 The the DT en-wikipedia-org-9224 1389 3 human human JJ en-wikipedia-org-9224 1389 4 mast mast JJ en-wikipedia-org-9224 1389 5 cell cell NN en-wikipedia-org-9224 1389 6 : : : en-wikipedia-org-9224 1389 7 an an DT en-wikipedia-org-9224 1389 8 overview overview NN en-wikipedia-org-9224 1389 9 " " '' en-wikipedia-org-9224 1389 10 . . . en-wikipedia-org-9224 1390 1 Mast mast JJ en-wikipedia-org-9224 1390 2 Cells cell NNS en-wikipedia-org-9224 1390 3 . . . en-wikipedia-org-9224 1391 1 Methods method NNS en-wikipedia-org-9224 1391 2 in in IN en-wikipedia-org-9224 1391 3 Molecular Molecular NNP en-wikipedia-org-9224 1391 4 Biology Biology NNP en-wikipedia-org-9224 1391 5 . . . en-wikipedia-org-9224 1392 1 315 315 CD en-wikipedia-org-9224 1392 2 . . . en-wikipedia-org-9224 1392 3 pp pp NNP en-wikipedia-org-9224 1392 4 . . . en-wikipedia-org-9224 1393 1 13–34 13–34 CD en-wikipedia-org-9224 1393 2 . . . en-wikipedia-org-9224 1394 1 doi:10.1385/1 doi:10.1385/1 LS en-wikipedia-org-9224 1394 2 - - : en-wikipedia-org-9224 1394 3 59259 59259 CD en-wikipedia-org-9224 1394 4 - - HYPH en-wikipedia-org-9224 1394 5 967 967 CD en-wikipedia-org-9224 1394 6 - - HYPH en-wikipedia-org-9224 1394 7 2:013 2:013 CD en-wikipedia-org-9224 1394 8 . . . en-wikipedia-org-9224 1395 1 ISBN ISBN NNP en-wikipedia-org-9224 1395 2   _SP en-wikipedia-org-9224 1395 3 1 1 CD en-wikipedia-org-9224 1395 4 - - HYPH en-wikipedia-org-9224 1395 5 59259 59259 CD en-wikipedia-org-9224 1395 6 - - HYPH en-wikipedia-org-9224 1395 7 967 967 CD en-wikipedia-org-9224 1395 8 - - HYPH en-wikipedia-org-9224 1395 9 2 2 CD en-wikipedia-org-9224 1395 10 . . . en-wikipedia-org-9224 1396 1 PMID PMID NNP en-wikipedia-org-9224 1396 2   _SP en-wikipedia-org-9224 1396 3 16110146 16110146 CD en-wikipedia-org-9224 1396 4 . . . en-wikipedia-org-9224 1397 1 Murphy Murphy NNP en-wikipedia-org-9224 1397 2 K K NNP en-wikipedia-org-9224 1397 3 , , , en-wikipedia-org-9224 1397 4 Weaver Weaver NNP en-wikipedia-org-9224 1397 5 C C NNP en-wikipedia-org-9224 1397 6 ( ( -LRB- en-wikipedia-org-9224 1397 7 2016 2016 CD en-wikipedia-org-9224 1397 8 ) ) -RRB- en-wikipedia-org-9224 1397 9 . . . en-wikipedia-org-9224 1398 1 Immunobiology immunobiology NN en-wikipedia-org-9224 1398 2 ( ( -LRB- en-wikipedia-org-9224 1398 3 9 9 CD en-wikipedia-org-9224 1398 4 ed ed NN en-wikipedia-org-9224 1398 5 . . . en-wikipedia-org-9224 1398 6 ) ) -RRB- en-wikipedia-org-9224 1398 7 . . . en-wikipedia-org-9224 1399 1 Garland Garland NNP en-wikipedia-org-9224 1399 2 Science Science NNP en-wikipedia-org-9224 1399 3 . . . en-wikipedia-org-9224 1400 1 ISBN ISBN NNP en-wikipedia-org-9224 1400 2   _SP en-wikipedia-org-9224 1400 3 978 978 CD en-wikipedia-org-9224 1400 4 - - HYPH en-wikipedia-org-9224 1400 5 0 0 CD en-wikipedia-org-9224 1400 6 - - HYPH en-wikipedia-org-9224 1400 7 8153 8153 CD en-wikipedia-org-9224 1400 8 - - HYPH en-wikipedia-org-9224 1400 9 4505 4505 CD en-wikipedia-org-9224 1400 10 - - SYM en-wikipedia-org-9224 1400 11 3 3 CD en-wikipedia-org-9224 1400 12 . . . en-wikipedia-org-9224 1401 1 Rajalingam Rajalingam NNP en-wikipedia-org-9224 1401 2 R R NNP en-wikipedia-org-9224 1401 3 ( ( -LRB- en-wikipedia-org-9224 1401 4 2012 2012 CD en-wikipedia-org-9224 1401 5 ) ) -RRB- en-wikipedia-org-9224 1401 6 . . . en-wikipedia-org-9224 1402 1 Immunogenetics immunogenetic NNS en-wikipedia-org-9224 1402 2 . . . en-wikipedia-org-9224 1403 1 Methods method NNS en-wikipedia-org-9224 1403 2 in in IN en-wikipedia-org-9224 1403 3 Molecular Molecular NNP en-wikipedia-org-9224 1403 4 Biology Biology NNP en-wikipedia-org-9224 1403 5 . . . en-wikipedia-org-9224 1404 1 Methods method NNS en-wikipedia-org-9224 1404 2 in in IN en-wikipedia-org-9224 1404 3 Molecular Molecular NNP en-wikipedia-org-9224 1404 4 Biology Biology NNP en-wikipedia-org-9224 1404 5 ™ ™ CD en-wikipedia-org-9224 1404 6 . . . en-wikipedia-org-9224 1405 1 882 882 CD en-wikipedia-org-9224 1405 2 . . . en-wikipedia-org-9224 1405 3 pp pp NNP en-wikipedia-org-9224 1405 4 . . . en-wikipedia-org-9224 1406 1 391–414 391–414 CD en-wikipedia-org-9224 1406 2 . . . en-wikipedia-org-9224 1407 1 doi:10.1007/978 doi:10.1007/978 NNP en-wikipedia-org-9224 1407 2 - - HYPH en-wikipedia-org-9224 1407 3 1 1 CD en-wikipedia-org-9224 1407 4 - - HYPH en-wikipedia-org-9224 1407 5 61779 61779 CD en-wikipedia-org-9224 1407 6 - - HYPH en-wikipedia-org-9224 1407 7 842 842 CD en-wikipedia-org-9224 1407 8 - - HYPH en-wikipedia-org-9224 1407 9 9_23 9_23 CD en-wikipedia-org-9224 1407 10 . . . en-wikipedia-org-9224 1408 1 ISBN ISBN NNP en-wikipedia-org-9224 1408 2   _SP en-wikipedia-org-9224 1408 3 978 978 CD en-wikipedia-org-9224 1408 4 - - HYPH en-wikipedia-org-9224 1408 5 1 1 CD en-wikipedia-org-9224 1408 6 - - HYPH en-wikipedia-org-9224 1408 7 61779 61779 CD en-wikipedia-org-9224 1408 8 - - HYPH en-wikipedia-org-9224 1408 9 841 841 CD en-wikipedia-org-9224 1408 10 - - HYPH en-wikipedia-org-9224 1408 11 2 2 CD en-wikipedia-org-9224 1408 12 . . . en-wikipedia-org-9224 1409 1 PMID PMID NNP en-wikipedia-org-9224 1409 2   _SP en-wikipedia-org-9224 1409 3 22665247 22665247 CD en-wikipedia-org-9224 1409 4 . . . en-wikipedia-org-9224 1410 1 Reece Reece NNP en-wikipedia-org-9224 1410 2 , , , en-wikipedia-org-9224 1410 3 Jane Jane NNP en-wikipedia-org-9224 1410 4 ( ( -LRB- en-wikipedia-org-9224 1410 5 2011 2011 CD en-wikipedia-org-9224 1410 6 ) ) -RRB- en-wikipedia-org-9224 1410 7 . . . en-wikipedia-org-9224 1411 1 Campbell Campbell NNP en-wikipedia-org-9224 1411 2 biology biology NN en-wikipedia-org-9224 1411 3 . . . en-wikipedia-org-9224 1412 1 Frenchs Frenchs NNP en-wikipedia-org-9224 1412 2 Forest Forest NNP en-wikipedia-org-9224 1412 3 , , , en-wikipedia-org-9224 1412 4 N.S.W N.S.W NNP en-wikipedia-org-9224 1412 5 : : : en-wikipedia-org-9224 1412 6 Pearson Pearson NNP en-wikipedia-org-9224 1412 7 Australia Australia NNP en-wikipedia-org-9224 1412 8 . . . en-wikipedia-org-9224 1413 1 ISBN ISBN NNP en-wikipedia-org-9224 1413 2   _SP en-wikipedia-org-9224 1413 3 978 978 CD en-wikipedia-org-9224 1413 4 - - HYPH en-wikipedia-org-9224 1413 5 1 1 CD en-wikipedia-org-9224 1413 6 - - HYPH en-wikipedia-org-9224 1413 7 4425 4425 CD en-wikipedia-org-9224 1413 8 - - HYPH en-wikipedia-org-9224 1413 9 3176 3176 CD en-wikipedia-org-9224 1413 10 - - HYPH en-wikipedia-org-9224 1413 11 5 5 CD en-wikipedia-org-9224 1413 12 . . . en-wikipedia-org-9224 1414 1 OCLC oclc NN en-wikipedia-org-9224 1414 2   _SP en-wikipedia-org-9224 1414 3 712136178 712136178 CD en-wikipedia-org-9224 1414 4 . . . en-wikipedia-org-9224 1415 1 Silverstein Silverstein NNP en-wikipedia-org-9224 1415 2 AM AM NNP en-wikipedia-org-9224 1415 3 ( ( -LRB- en-wikipedia-org-9224 1415 4 1989 1989 CD en-wikipedia-org-9224 1415 5 ) ) -RRB- en-wikipedia-org-9224 1415 6 . . . en-wikipedia-org-9224 1416 1 A a DT en-wikipedia-org-9224 1416 2 History history NN en-wikipedia-org-9224 1416 3 of of IN en-wikipedia-org-9224 1416 4 Immunology immunology NN en-wikipedia-org-9224 1416 5 . . . en-wikipedia-org-9224 1417 1 Academic Academic NNP en-wikipedia-org-9224 1417 2 Press Press NNP en-wikipedia-org-9224 1417 3 . . . en-wikipedia-org-9224 1418 1 ISBN ISBN NNP en-wikipedia-org-9224 1418 2   _SP en-wikipedia-org-9224 1418 3 978 978 CD en-wikipedia-org-9224 1418 4 - - HYPH en-wikipedia-org-9224 1418 5 0 0 CD en-wikipedia-org-9224 1418 6 - - HYPH en-wikipedia-org-9224 1418 7 08 08 CD en-wikipedia-org-9224 1418 8 - - HYPH en-wikipedia-org-9224 1418 9 092583 092583 CD en-wikipedia-org-9224 1418 10 - - SYM en-wikipedia-org-9224 1418 11 7 7 CD en-wikipedia-org-9224 1418 12 . . . en-wikipedia-org-9224 1419 1 Sompayrac Sompayrac NNP en-wikipedia-org-9224 1419 2 L L NNP en-wikipedia-org-9224 1419 3 ( ( -LRB- en-wikipedia-org-9224 1419 4 2019 2019 CD en-wikipedia-org-9224 1419 5 ) ) -RRB- en-wikipedia-org-9224 1419 6 . . . en-wikipedia-org-9224 1420 1 How how WRB en-wikipedia-org-9224 1420 2 the the DT en-wikipedia-org-9224 1420 3 immune immune JJ en-wikipedia-org-9224 1420 4 system system NN en-wikipedia-org-9224 1420 5 works work VBZ en-wikipedia-org-9224 1420 6 . . . en-wikipedia-org-9224 1421 1 Hoboken Hoboken NNP en-wikipedia-org-9224 1421 2 , , , en-wikipedia-org-9224 1421 3 NJ NJ NNP en-wikipedia-org-9224 1421 4 : : : en-wikipedia-org-9224 1421 5 Wiley Wiley NNP en-wikipedia-org-9224 1421 6 - - HYPH en-wikipedia-org-9224 1421 7 Blackwell Blackwell NNP en-wikipedia-org-9224 1421 8 . . . en-wikipedia-org-9224 1422 1 ISBN ISBN NNP en-wikipedia-org-9224 1422 2   _SP en-wikipedia-org-9224 1422 3 978 978 CD en-wikipedia-org-9224 1422 4 - - HYPH en-wikipedia-org-9224 1422 5 1 1 CD en-wikipedia-org-9224 1422 6 - - HYPH en-wikipedia-org-9224 1422 7 119 119 CD en-wikipedia-org-9224 1422 8 - - HYPH en-wikipedia-org-9224 1422 9 54212 54212 CD en-wikipedia-org-9224 1422 10 - - SYM en-wikipedia-org-9224 1422 11 4 4 CD en-wikipedia-org-9224 1422 12 . . . en-wikipedia-org-9224 1423 1 OCLC oclc NN en-wikipedia-org-9224 1423 2   _SP en-wikipedia-org-9224 1423 3 1083261548 1083261548 CD en-wikipedia-org-9224 1423 4 . . . en-wikipedia-org-9224 1424 1 Stvrtinová Stvrtinová NNP en-wikipedia-org-9224 1424 2 V V NNP en-wikipedia-org-9224 1424 3 , , , en-wikipedia-org-9224 1424 4 Jakubovský Jakubovský NNP en-wikipedia-org-9224 1424 5 J J NNP en-wikipedia-org-9224 1424 6 , , , en-wikipedia-org-9224 1424 7 Hulín Hulín NNP en-wikipedia-org-9224 1424 8 I I NNP en-wikipedia-org-9224 1424 9 ( ( -LRB- en-wikipedia-org-9224 1424 10 1995 1995 CD en-wikipedia-org-9224 1424 11 ) ) -RRB- en-wikipedia-org-9224 1424 12 . . . en-wikipedia-org-9224 1425 1 Pathophysiology pathophysiology NN en-wikipedia-org-9224 1425 2 : : : en-wikipedia-org-9224 1425 3 Principles principle NNS en-wikipedia-org-9224 1425 4 of of IN en-wikipedia-org-9224 1425 5 Disease Disease NNP en-wikipedia-org-9224 1425 6 . . . en-wikipedia-org-9224 1426 1 Computing Computing NNP en-wikipedia-org-9224 1426 2 Centre Centre NNP en-wikipedia-org-9224 1426 3 , , , en-wikipedia-org-9224 1426 4 Slovak Slovak NNP en-wikipedia-org-9224 1426 5 Academy Academy NNP en-wikipedia-org-9224 1426 6 of of IN en-wikipedia-org-9224 1426 7 Sciences Sciences NNPS en-wikipedia-org-9224 1426 8 : : : en-wikipedia-org-9224 1426 9 Academic Academic NNP en-wikipedia-org-9224 1426 10 Electronic Electronic NNP en-wikipedia-org-9224 1426 11 Press Press NNP en-wikipedia-org-9224 1426 12 . . . en-wikipedia-org-9224 1427 1 Wira Wira NNP en-wikipedia-org-9224 1427 2 CR CR NNP en-wikipedia-org-9224 1427 3 , , , en-wikipedia-org-9224 1427 4 Crane Crane NNP en-wikipedia-org-9224 1427 5 - - HYPH en-wikipedia-org-9224 1427 6 Godreau Godreau NNP en-wikipedia-org-9224 1427 7 M M NNP en-wikipedia-org-9224 1427 8 , , , en-wikipedia-org-9224 1427 9 Grant Grant NNP en-wikipedia-org-9224 1427 10 K K NNP en-wikipedia-org-9224 1427 11 ( ( -LRB- en-wikipedia-org-9224 1427 12 2004 2004 CD en-wikipedia-org-9224 1427 13 ) ) -RRB- en-wikipedia-org-9224 1427 14 . . . en-wikipedia-org-9224 1428 1 Ogra Ogra NNP en-wikipedia-org-9224 1428 2 PL PL NNP en-wikipedia-org-9224 1428 3 , , , en-wikipedia-org-9224 1428 4 Mestecky Mestecky NNP en-wikipedia-org-9224 1428 5 J J NNP en-wikipedia-org-9224 1428 6 , , , en-wikipedia-org-9224 1428 7 Lamm Lamm NNP en-wikipedia-org-9224 1428 8 ME ME NNP en-wikipedia-org-9224 1428 9 , , , en-wikipedia-org-9224 1428 10 Strober Strober NNP en-wikipedia-org-9224 1428 11 W W NNP en-wikipedia-org-9224 1428 12 , , , en-wikipedia-org-9224 1428 13 McGhee McGhee NNP en-wikipedia-org-9224 1428 14 JR JR NNP en-wikipedia-org-9224 1428 15 , , , en-wikipedia-org-9224 1428 16 Bienenstock Bienenstock NNP en-wikipedia-org-9224 1428 17 J J NNP en-wikipedia-org-9224 1428 18 ( ( -LRB- en-wikipedia-org-9224 1428 19 eds eds NNP en-wikipedia-org-9224 1428 20 . . . en-wikipedia-org-9224 1428 21 ) ) -RRB- en-wikipedia-org-9224 1428 22 . . . en-wikipedia-org-9224 1429 1 Mucosal Mucosal NNP en-wikipedia-org-9224 1429 2 Immunology Immunology NNP en-wikipedia-org-9224 1429 3 . . . en-wikipedia-org-9224 1430 1 San San NNP en-wikipedia-org-9224 1430 2 Francisco Francisco NNP en-wikipedia-org-9224 1430 3 : : : en-wikipedia-org-9224 1430 4 Elsevier Elsevier NNP en-wikipedia-org-9224 1430 5 . . . en-wikipedia-org-9224 1431 1 ISBN ISBN NNP en-wikipedia-org-9224 1431 2   _SP en-wikipedia-org-9224 1431 3 0 0 CD en-wikipedia-org-9224 1431 4 - - HYPH en-wikipedia-org-9224 1431 5 12 12 CD en-wikipedia-org-9224 1431 6 - - HYPH en-wikipedia-org-9224 1431 7 491543 491543 CD en-wikipedia-org-9224 1431 8 - - SYM en-wikipedia-org-9224 1431 9 4 4 CD en-wikipedia-org-9224 1431 10 . . . en-wikipedia-org-9224 1432 1 External external JJ en-wikipedia-org-9224 1432 2 links[edit links[edit , en-wikipedia-org-9224 1432 3 ] ] -RRB- en-wikipedia-org-9224 1432 4 Wikimedia Wikimedia NNP en-wikipedia-org-9224 1432 5 Commons Commons NNPS en-wikipedia-org-9224 1432 6 has have VBZ en-wikipedia-org-9224 1432 7 media medium NNS en-wikipedia-org-9224 1432 8 related relate VBN en-wikipedia-org-9224 1432 9 to to IN en-wikipedia-org-9224 1432 10 Immune Immune NNP en-wikipedia-org-9224 1432 11 system system NN en-wikipedia-org-9224 1432 12 . . . en-wikipedia-org-9224 1433 1 Wikiquote Wikiquote NNP en-wikipedia-org-9224 1433 2 has have VBZ en-wikipedia-org-9224 1433 3 quotations quotation NNS en-wikipedia-org-9224 1433 4 related relate VBN en-wikipedia-org-9224 1433 5 to to IN en-wikipedia-org-9224 1433 6 : : : en-wikipedia-org-9224 1433 7 Immune immune JJ en-wikipedia-org-9224 1433 8 system system NN en-wikipedia-org-9224 1433 9 Library library JJ en-wikipedia-org-9224 1433 10 resources resource NNS en-wikipedia-org-9224 1433 11 about about IN en-wikipedia-org-9224 1433 12 Immune immune JJ en-wikipedia-org-9224 1433 13 system system NN en-wikipedia-org-9224 1433 14 Online online JJ en-wikipedia-org-9224 1433 15 books book NNS en-wikipedia-org-9224 1433 16 Resources resource NNS en-wikipedia-org-9224 1433 17 in in IN en-wikipedia-org-9224 1433 18 your -PRON- PRP$ en-wikipedia-org-9224 1433 19 library library NN en-wikipedia-org-9224 1433 20 Resources Resources NNPS en-wikipedia-org-9224 1433 21 in in IN en-wikipedia-org-9224 1433 22 other other JJ en-wikipedia-org-9224 1433 23 libraries library NNS en-wikipedia-org-9224 1433 24 Microbiology Microbiology NNP en-wikipedia-org-9224 1433 25 and and CC en-wikipedia-org-9224 1433 26 Immunology Immunology NNP en-wikipedia-org-9224 1433 27 On On NNP en-wikipedia-org-9224 1433 28 - - HYPH en-wikipedia-org-9224 1433 29 Line Line NNP en-wikipedia-org-9224 1433 30 Textbook Textbook NNP en-wikipedia-org-9224 1433 31 – – : en-wikipedia-org-9224 1433 32 from from IN en-wikipedia-org-9224 1433 33 the the DT en-wikipedia-org-9224 1433 34 University University NNP en-wikipedia-org-9224 1433 35 of of IN en-wikipedia-org-9224 1433 36 South South NNP en-wikipedia-org-9224 1433 37 Carolina Carolina NNP en-wikipedia-org-9224 1433 38 School School NNP en-wikipedia-org-9224 1433 39 of of IN en-wikipedia-org-9224 1433 40 Medicine Medicine NNP en-wikipedia-org-9224 1433 41 ( ( -LRB- en-wikipedia-org-9224 1433 42 undergraduate undergraduate JJ en-wikipedia-org-9224 1433 43 level level NN en-wikipedia-org-9224 1433 44 ) ) -RRB- en-wikipedia-org-9224 1433 45 v v LS en-wikipedia-org-9224 1433 46 t t NN en-wikipedia-org-9224 1433 47 e e NN en-wikipedia-org-9224 1433 48 Lymphocytic lymphocytic JJ en-wikipedia-org-9224 1433 49 adaptive adaptive JJ en-wikipedia-org-9224 1433 50 immune immune JJ en-wikipedia-org-9224 1433 51 system system NN en-wikipedia-org-9224 1433 52 and and CC en-wikipedia-org-9224 1433 53 complement complement NN en-wikipedia-org-9224 1433 54 Lymphoid Lymphoid NNP en-wikipedia-org-9224 1433 55 Antigens Antigens NNP en-wikipedia-org-9224 1433 56 Antigen Antigen NNP en-wikipedia-org-9224 1433 57 Superantigen Superantigen NNP en-wikipedia-org-9224 1433 58 Allergen Allergen NNP en-wikipedia-org-9224 1433 59 Antigenic antigenic JJ en-wikipedia-org-9224 1433 60 variation variation NN en-wikipedia-org-9224 1433 61 Hapten Hapten NNP en-wikipedia-org-9224 1433 62 Epitope Epitope NNP en-wikipedia-org-9224 1433 63 Linear Linear NNP en-wikipedia-org-9224 1433 64 Conformational Conformational NNP en-wikipedia-org-9224 1433 65 Mimotope Mimotope NNP en-wikipedia-org-9224 1433 66 Antigen Antigen NNP en-wikipedia-org-9224 1433 67 presentation presentation NN en-wikipedia-org-9224 1433 68 / / SYM en-wikipedia-org-9224 1433 69 Professional professional JJ en-wikipedia-org-9224 1433 70 APCs apc NNS en-wikipedia-org-9224 1433 71 : : : en-wikipedia-org-9224 1433 72 Dendritic dendritic JJ en-wikipedia-org-9224 1433 73 cell cell NN en-wikipedia-org-9224 1433 74 Macrophage Macrophage NNP en-wikipedia-org-9224 1433 75 B B NNP en-wikipedia-org-9224 1433 76 cell cell NN en-wikipedia-org-9224 1433 77 Immunogen Immunogen NNP en-wikipedia-org-9224 1433 78 Antibodies Antibodies NNP en-wikipedia-org-9224 1433 79 Antibody Antibody NNP en-wikipedia-org-9224 1433 80 Monoclonal Monoclonal NNP en-wikipedia-org-9224 1433 81 antibodies antibodie VBZ en-wikipedia-org-9224 1433 82 Polyclonal Polyclonal NNP en-wikipedia-org-9224 1433 83 antibodies antibodie VBZ en-wikipedia-org-9224 1433 84 Autoantibody Autoantibody NNP en-wikipedia-org-9224 1433 85 Microantibody Microantibody NNP en-wikipedia-org-9224 1433 86 Polyclonal Polyclonal NNP en-wikipedia-org-9224 1433 87 B B NNP en-wikipedia-org-9224 1433 88 cell cell NN en-wikipedia-org-9224 1433 89 response response NN en-wikipedia-org-9224 1433 90 Allotype Allotype NNP en-wikipedia-org-9224 1433 91 Isotype Isotype NNP en-wikipedia-org-9224 1433 92 Idiotype Idiotype NNP en-wikipedia-org-9224 1433 93 Immune Immune NNP en-wikipedia-org-9224 1433 94 complex complex JJ en-wikipedia-org-9224 1433 95 Paratope Paratope NNP en-wikipedia-org-9224 1433 96 Immunity Immunity NNP en-wikipedia-org-9224 1433 97 vs. vs. IN en-wikipedia-org-9224 1433 98 tolerance tolerance NN en-wikipedia-org-9224 1433 99 action action NN en-wikipedia-org-9224 1433 100 : : : en-wikipedia-org-9224 1433 101 Immunity immunity NN en-wikipedia-org-9224 1433 102 Autoimmunity Autoimmunity NNP en-wikipedia-org-9224 1433 103 Alloimmunity Alloimmunity NNP en-wikipedia-org-9224 1433 104 Allergy Allergy NNP en-wikipedia-org-9224 1433 105 Hypersensitivity Hypersensitivity NNP en-wikipedia-org-9224 1433 106 Inflammation Inflammation NNP en-wikipedia-org-9224 1433 107 Cross Cross NNP en-wikipedia-org-9224 1433 108 - - JJ en-wikipedia-org-9224 1433 109 reactivity reactivity NN en-wikipedia-org-9224 1433 110 inaction inaction NN en-wikipedia-org-9224 1433 111 : : : en-wikipedia-org-9224 1433 112 Tolerance tolerance VB en-wikipedia-org-9224 1433 113 Central Central NNP en-wikipedia-org-9224 1433 114 Peripheral Peripheral NNP en-wikipedia-org-9224 1433 115 Clonal Clonal NNP en-wikipedia-org-9224 1433 116 anergy anergy NN en-wikipedia-org-9224 1433 117 Clonal clonal JJ en-wikipedia-org-9224 1433 118 deletion deletion NN en-wikipedia-org-9224 1433 119 Tolerance tolerance NN en-wikipedia-org-9224 1433 120 in in IN en-wikipedia-org-9224 1433 121 pregnancy pregnancy NN en-wikipedia-org-9224 1433 122 Immunodeficiency Immunodeficiency NNP en-wikipedia-org-9224 1433 123 Immune Immune NNP en-wikipedia-org-9224 1433 124 privilege privilege NN en-wikipedia-org-9224 1433 125 Immunogenetics Immunogenetics NNP en-wikipedia-org-9224 1433 126 Affinity Affinity NNP en-wikipedia-org-9224 1433 127 maturation maturation NN en-wikipedia-org-9224 1433 128 Somatic somatic JJ en-wikipedia-org-9224 1433 129 hypermutation hypermutation NN en-wikipedia-org-9224 1433 130 Clonal Clonal NNP en-wikipedia-org-9224 1433 131 selection selection NN en-wikipedia-org-9224 1433 132 V(D)J V(D)J NNP en-wikipedia-org-9224 1433 133 recombination recombination NN en-wikipedia-org-9224 1433 134 Junctional Junctional NNP en-wikipedia-org-9224 1433 135 diversity diversity NN en-wikipedia-org-9224 1433 136 Immunoglobulin immunoglobulin JJ en-wikipedia-org-9224 1433 137 class class NN en-wikipedia-org-9224 1433 138 switching switch VBG en-wikipedia-org-9224 1433 139 MHC MHC NNP en-wikipedia-org-9224 1433 140 / / SYM en-wikipedia-org-9224 1433 141 HLA HLA NNP en-wikipedia-org-9224 1433 142 Lymphocytes lymphocyte VBZ en-wikipedia-org-9224 1433 143 Cellular cellular JJ en-wikipedia-org-9224 1433 144 T T NNP en-wikipedia-org-9224 1433 145 cell cell NN en-wikipedia-org-9224 1433 146 Humoral Humoral NNP en-wikipedia-org-9224 1433 147 B B NNP en-wikipedia-org-9224 1433 148 cell cell NN en-wikipedia-org-9224 1433 149 NK NK NNP en-wikipedia-org-9224 1433 150 cell cell NN en-wikipedia-org-9224 1433 151 Substances Substances NNP en-wikipedia-org-9224 1433 152 Cytokines Cytokines NNPS en-wikipedia-org-9224 1433 153 Opsonin Opsonin NNP en-wikipedia-org-9224 1433 154 Cytolysin Cytolysin NNP en-wikipedia-org-9224 1433 155 v v NN en-wikipedia-org-9224 1433 156 t t NN en-wikipedia-org-9224 1433 157 e e NN en-wikipedia-org-9224 1433 158 Organs organ NNS en-wikipedia-org-9224 1433 159 of of IN en-wikipedia-org-9224 1433 160 the the DT en-wikipedia-org-9224 1433 161 lymphatic lymphatic JJ en-wikipedia-org-9224 1433 162 system system NN en-wikipedia-org-9224 1433 163 Primary primary JJ en-wikipedia-org-9224 1433 164 organs organ NNS en-wikipedia-org-9224 1433 165 Bone bone NN en-wikipedia-org-9224 1433 166 marrow marrow NN en-wikipedia-org-9224 1433 167 Hematopoietic hematopoietic JJ en-wikipedia-org-9224 1433 168 stem stem NN en-wikipedia-org-9224 1433 169 cell cell NN en-wikipedia-org-9224 1433 170 Thymus Thymus NNP en-wikipedia-org-9224 1433 171 Hassall Hassall NNP en-wikipedia-org-9224 1433 172 's 's POS en-wikipedia-org-9224 1433 173 corpuscles corpuscle NNS en-wikipedia-org-9224 1433 174 Secondary secondary JJ en-wikipedia-org-9224 1433 175 organs organ NNS en-wikipedia-org-9224 1433 176 Spleen spleen NN en-wikipedia-org-9224 1433 177 Parts part NNS en-wikipedia-org-9224 1433 178 Hilum Hilum NNP en-wikipedia-org-9224 1433 179 Trabeculae Trabeculae NNP en-wikipedia-org-9224 1433 180 Red Red NNP en-wikipedia-org-9224 1433 181 pulp pulp NN en-wikipedia-org-9224 1433 182 Cords Cords NNPS en-wikipedia-org-9224 1433 183 of of IN en-wikipedia-org-9224 1433 184 Billroth Billroth NNP en-wikipedia-org-9224 1433 185 Marginal Marginal NNP en-wikipedia-org-9224 1433 186 zone zone NN en-wikipedia-org-9224 1433 187 White White NNP en-wikipedia-org-9224 1433 188 pulp pulp NN en-wikipedia-org-9224 1433 189 Periarteriolar Periarteriolar NNP en-wikipedia-org-9224 1433 190 lymphoid lymphoid NN en-wikipedia-org-9224 1433 191 sheaths sheath NNS en-wikipedia-org-9224 1433 192 Germinal Germinal NNP en-wikipedia-org-9224 1433 193 center center NN en-wikipedia-org-9224 1433 194 Blood blood NN en-wikipedia-org-9224 1433 195 vessels vessel VBZ en-wikipedia-org-9224 1433 196 Trabecular Trabecular NNP en-wikipedia-org-9224 1433 197 arteries artery NNS en-wikipedia-org-9224 1433 198 Trabecular Trabecular NNP en-wikipedia-org-9224 1433 199 veins vein VBZ en-wikipedia-org-9224 1433 200 Tonsils Tonsils NNP en-wikipedia-org-9224 1433 201 Palatine Palatine NNP en-wikipedia-org-9224 1433 202 Lingual Lingual NNP en-wikipedia-org-9224 1433 203 Pharyngeal Pharyngeal NNP en-wikipedia-org-9224 1433 204 Tubal Tubal NNP en-wikipedia-org-9224 1433 205 Tonsillar Tonsillar NNP en-wikipedia-org-9224 1433 206 crypts crypt VBZ en-wikipedia-org-9224 1433 207 Waldeyer Waldeyer NNP en-wikipedia-org-9224 1433 208 's 's POS en-wikipedia-org-9224 1433 209 tonsillar tonsillar JJ en-wikipedia-org-9224 1433 210 ring ring NN en-wikipedia-org-9224 1433 211 Lymph Lymph NNP en-wikipedia-org-9224 1433 212 nodes node NNS en-wikipedia-org-9224 1433 213 Lymphatic lymphatic JJ en-wikipedia-org-9224 1433 214 vessel vessel NN en-wikipedia-org-9224 1433 215 T t NN en-wikipedia-org-9224 1433 216 cells cell NNS en-wikipedia-org-9224 1433 217 High high JJ en-wikipedia-org-9224 1433 218 endothelial endothelial JJ en-wikipedia-org-9224 1433 219 venules venule NNS en-wikipedia-org-9224 1433 220 B b NN en-wikipedia-org-9224 1433 221 cells cell NNS en-wikipedia-org-9224 1433 222 Germinal Germinal NNP en-wikipedia-org-9224 1433 223 center center NN en-wikipedia-org-9224 1433 224 Mantle Mantle NNP en-wikipedia-org-9224 1433 225 zone zone NN en-wikipedia-org-9224 1433 226 Marginal Marginal NNP en-wikipedia-org-9224 1433 227 zone zone NN en-wikipedia-org-9224 1433 228 MALT MALT NNP en-wikipedia-org-9224 1433 229 GALT GALT NNP en-wikipedia-org-9224 1433 230 Peyer Peyer NNP en-wikipedia-org-9224 1433 231 's 's POS en-wikipedia-org-9224 1433 232 patch patch NN en-wikipedia-org-9224 1433 233 Germinal germinal JJ en-wikipedia-org-9224 1433 234 center center NN en-wikipedia-org-9224 1433 235 v v NNP en-wikipedia-org-9224 1433 236 t t NN en-wikipedia-org-9224 1433 237 e e NNP en-wikipedia-org-9224 1433 238 Human Human NNP en-wikipedia-org-9224 1433 239 systems system NNS en-wikipedia-org-9224 1433 240 and and CC en-wikipedia-org-9224 1433 241 organs organ NNS en-wikipedia-org-9224 1433 242 Musculoskeletal musculoskeletal JJ en-wikipedia-org-9224 1433 243 Skeletal skeletal JJ en-wikipedia-org-9224 1433 244 system system NN en-wikipedia-org-9224 1433 245 Bone Bone NNP en-wikipedia-org-9224 1433 246 Carpus Carpus NNP en-wikipedia-org-9224 1433 247 Collar Collar NNP en-wikipedia-org-9224 1433 248 bone bone NN en-wikipedia-org-9224 1433 249 ( ( -LRB- en-wikipedia-org-9224 1433 250 clavicle clavicle NNP en-wikipedia-org-9224 1433 251 ) ) -RRB- en-wikipedia-org-9224 1433 252 Thigh Thigh NNP en-wikipedia-org-9224 1433 253 bone bone NN en-wikipedia-org-9224 1433 254 ( ( -LRB- en-wikipedia-org-9224 1433 255 femur femur NN en-wikipedia-org-9224 1433 256 ) ) -RRB- en-wikipedia-org-9224 1433 257 Fibula Fibula NNP en-wikipedia-org-9224 1433 258 Humerus Humerus NNP en-wikipedia-org-9224 1433 259 Mandible Mandible NNP en-wikipedia-org-9224 1433 260 Metacarpus Metacarpus NNP en-wikipedia-org-9224 1433 261 Metatarsus Metatarsus NNP en-wikipedia-org-9224 1433 262 Ossicles Ossicles NNP en-wikipedia-org-9224 1433 263 Patella Patella NNP en-wikipedia-org-9224 1433 264 Phalanges Phalanges NNP en-wikipedia-org-9224 1433 265 Radius Radius NNP en-wikipedia-org-9224 1433 266 Skull Skull NNP en-wikipedia-org-9224 1433 267 Tarsus Tarsus NNP en-wikipedia-org-9224 1433 268 Tibia Tibia NNP en-wikipedia-org-9224 1433 269 Ulna Ulna NNP en-wikipedia-org-9224 1433 270 Rib Rib NNP en-wikipedia-org-9224 1433 271 Vertebra Vertebra NNP en-wikipedia-org-9224 1433 272 Pelvis Pelvis NNP en-wikipedia-org-9224 1433 273 Sternum Sternum NNP en-wikipedia-org-9224 1433 274 Cartilage Cartilage NNP en-wikipedia-org-9224 1433 275 Joints Joints NNP en-wikipedia-org-9224 1433 276 Fibrous fibrous JJ en-wikipedia-org-9224 1433 277 joint joint JJ en-wikipedia-org-9224 1433 278 Cartilaginous cartilaginous JJ en-wikipedia-org-9224 1433 279 joint joint JJ en-wikipedia-org-9224 1433 280 Synovial synovial JJ en-wikipedia-org-9224 1433 281 joint joint NN en-wikipedia-org-9224 1433 282 Muscular muscular JJ en-wikipedia-org-9224 1433 283 system system NN en-wikipedia-org-9224 1433 284 Muscle Muscle NNP en-wikipedia-org-9224 1433 285 Tendon Tendon NNP en-wikipedia-org-9224 1433 286 Diaphragm Diaphragm NNP en-wikipedia-org-9224 1433 287 Circulatory Circulatory NNP en-wikipedia-org-9224 1433 288 system system NN en-wikipedia-org-9224 1433 289 Cardiovascular Cardiovascular NNP en-wikipedia-org-9224 1433 290 system system NN en-wikipedia-org-9224 1433 291 peripheral peripheral NN en-wikipedia-org-9224 1433 292 Artery Artery NNP en-wikipedia-org-9224 1433 293 Vein Vein NNP en-wikipedia-org-9224 1433 294 Lymphatic Lymphatic NNP en-wikipedia-org-9224 1433 295 vessel vessel NN en-wikipedia-org-9224 1433 296 Heart Heart NNP en-wikipedia-org-9224 1433 297 Lymphatic Lymphatic NNP en-wikipedia-org-9224 1433 298 system system NN en-wikipedia-org-9224 1433 299 primary primary NN en-wikipedia-org-9224 1433 300 Bone Bone NNP en-wikipedia-org-9224 1433 301 marrow marrow NN en-wikipedia-org-9224 1433 302 Thymus Thymus NNP en-wikipedia-org-9224 1433 303 secondary secondary JJ en-wikipedia-org-9224 1433 304 Spleen Spleen NNP en-wikipedia-org-9224 1433 305 Lymph Lymph NNP en-wikipedia-org-9224 1433 306 node node RB en-wikipedia-org-9224 1433 307 CNS cn VBD en-wikipedia-org-9224 1433 308 equivalent equivalent JJ en-wikipedia-org-9224 1433 309 Glymphatic glymphatic JJ en-wikipedia-org-9224 1433 310 system system NN en-wikipedia-org-9224 1433 311 Nervous nervous JJ en-wikipedia-org-9224 1433 312 system system NN en-wikipedia-org-9224 1433 313 Brain Brain NNP en-wikipedia-org-9224 1433 314 Spinal spinal JJ en-wikipedia-org-9224 1433 315 cord cord NN en-wikipedia-org-9224 1433 316 Nerve Nerve NNP en-wikipedia-org-9224 1433 317 Sensory Sensory NNP en-wikipedia-org-9224 1433 318 system system NN en-wikipedia-org-9224 1433 319 Ear Ear NNP en-wikipedia-org-9224 1433 320 Eye Eye NNP en-wikipedia-org-9224 1433 321 Integumentary Integumentary NNP en-wikipedia-org-9224 1433 322 system system NN en-wikipedia-org-9224 1433 323 Skin skin NN en-wikipedia-org-9224 1433 324 Subcutaneous subcutaneous JJ en-wikipedia-org-9224 1433 325 tissue tissue NN en-wikipedia-org-9224 1433 326 Breast Breast NNP en-wikipedia-org-9224 1433 327 Mammary mammary JJ en-wikipedia-org-9224 1433 328 gland gland NN en-wikipedia-org-9224 1433 329 Hematopoietic hematopoietic JJ en-wikipedia-org-9224 1433 330 and and CC en-wikipedia-org-9224 1433 331 immune immune JJ en-wikipedia-org-9224 1433 332 systems system NNS en-wikipedia-org-9224 1433 333 Myeloid Myeloid NNP en-wikipedia-org-9224 1433 334 Myeloid Myeloid NNP en-wikipedia-org-9224 1433 335 immune immune JJ en-wikipedia-org-9224 1433 336 system system NN en-wikipedia-org-9224 1433 337 Lymphoid Lymphoid NNP en-wikipedia-org-9224 1433 338 Lymphoid Lymphoid NNP en-wikipedia-org-9224 1433 339 immune immune JJ en-wikipedia-org-9224 1433 340 system system NN en-wikipedia-org-9224 1433 341 Respiratory respiratory JJ en-wikipedia-org-9224 1433 342 system system NN en-wikipedia-org-9224 1433 343 Upper Upper NNP en-wikipedia-org-9224 1433 344 Nose Nose NNP en-wikipedia-org-9224 1433 345 Nasopharynx Nasopharynx NNP en-wikipedia-org-9224 1433 346 Larynx Larynx NNP en-wikipedia-org-9224 1433 347 Lower Lower NNP en-wikipedia-org-9224 1433 348 Trachea Trachea NNP en-wikipedia-org-9224 1433 349 Bronchus Bronchus NNP en-wikipedia-org-9224 1433 350 Lung Lung NNP en-wikipedia-org-9224 1433 351 Digestive Digestive NNP en-wikipedia-org-9224 1433 352 system system NN en-wikipedia-org-9224 1433 353 Mouth Mouth NNP en-wikipedia-org-9224 1433 354 Salivary Salivary NNP en-wikipedia-org-9224 1433 355 gland gland NN en-wikipedia-org-9224 1433 356 Tongue Tongue NNP en-wikipedia-org-9224 1433 357 Lips Lips NNP en-wikipedia-org-9224 1433 358 upper upper JJ en-wikipedia-org-9224 1433 359 GI GI NNP en-wikipedia-org-9224 1433 360 Oropharynx Oropharynx NNP en-wikipedia-org-9224 1433 361 Laryngopharynx Laryngopharynx NNP en-wikipedia-org-9224 1433 362 Esophagus Esophagus NNP en-wikipedia-org-9224 1433 363 Stomach Stomach NNP en-wikipedia-org-9224 1433 364 lower low JJR en-wikipedia-org-9224 1433 365 GI GI NNP en-wikipedia-org-9224 1433 366 Small small JJ en-wikipedia-org-9224 1433 367 intestine intestine NN en-wikipedia-org-9224 1433 368 Appendix Appendix NNP en-wikipedia-org-9224 1433 369 Colon Colon NNP en-wikipedia-org-9224 1433 370 Rectum Rectum NNP en-wikipedia-org-9224 1433 371 Anus Anus NNP en-wikipedia-org-9224 1433 372 accessory accessory NN en-wikipedia-org-9224 1433 373 Liver Liver NNP en-wikipedia-org-9224 1433 374 Biliary Biliary NNP en-wikipedia-org-9224 1433 375 tract tract NN en-wikipedia-org-9224 1433 376 Pancreas Pancreas NNP en-wikipedia-org-9224 1433 377 Urinary Urinary NNP en-wikipedia-org-9224 1433 378 system system NN en-wikipedia-org-9224 1433 379 Genitourinary Genitourinary NNP en-wikipedia-org-9224 1433 380 system system NN en-wikipedia-org-9224 1433 381 Kidney Kidney NNP en-wikipedia-org-9224 1433 382 Ureter Ureter NNP en-wikipedia-org-9224 1433 383 Bladder Bladder NNP en-wikipedia-org-9224 1433 384 Urethra Urethra NNP en-wikipedia-org-9224 1433 385 Reproductive Reproductive NNP en-wikipedia-org-9224 1433 386 system system NN en-wikipedia-org-9224 1433 387 Male Male NNP en-wikipedia-org-9224 1433 388 Scrotum Scrotum NNP en-wikipedia-org-9224 1433 389 Penis Penis NNP en-wikipedia-org-9224 1433 390 Size Size NNP en-wikipedia-org-9224 1433 391 Prostate Prostate NNP en-wikipedia-org-9224 1433 392 Testicle Testicle NNP en-wikipedia-org-9224 1433 393 Seminal Seminal NNP en-wikipedia-org-9224 1433 394 vesicle vesicle NN en-wikipedia-org-9224 1433 395 Female female JJ en-wikipedia-org-9224 1433 396 Uterus Uterus NNP en-wikipedia-org-9224 1433 397 Vagina Vagina NNP en-wikipedia-org-9224 1433 398 Vulva Vulva NNP en-wikipedia-org-9224 1433 399 Ovary Ovary NNP en-wikipedia-org-9224 1433 400 Placenta Placenta NNP en-wikipedia-org-9224 1433 401 Endocrine Endocrine NNP en-wikipedia-org-9224 1433 402 system system NN en-wikipedia-org-9224 1433 403 Pituitary Pituitary NNP en-wikipedia-org-9224 1433 404 Pineal Pineal NNP en-wikipedia-org-9224 1433 405 Thyroid Thyroid NNP en-wikipedia-org-9224 1433 406 Parathyroid Parathyroid NNP en-wikipedia-org-9224 1433 407 Adrenal Adrenal NNP en-wikipedia-org-9224 1433 408 Islets Islets NNPS en-wikipedia-org-9224 1433 409 of of IN en-wikipedia-org-9224 1433 410 Langerhans Langerhans NNPS en-wikipedia-org-9224 1433 411 v v IN en-wikipedia-org-9224 1433 412 t t NN en-wikipedia-org-9224 1433 413 e e NNP en-wikipedia-org-9224 1433 414 Transmembrane Transmembrane NNP en-wikipedia-org-9224 1433 415 receptors receptor NNS en-wikipedia-org-9224 1433 416 : : : en-wikipedia-org-9224 1433 417 immunoglobulin immunoglobulin NNP en-wikipedia-org-9224 1433 418 superfamily superfamily RB en-wikipedia-org-9224 1433 419 immune immune JJ en-wikipedia-org-9224 1433 420 receptors receptor NNS en-wikipedia-org-9224 1433 421 Antibody Antibody NNP en-wikipedia-org-9224 1433 422 receptor receptor NN en-wikipedia-org-9224 1433 423 : : : en-wikipedia-org-9224 1433 424 Fc Fc NNP en-wikipedia-org-9224 1433 425 receptor receptor NN en-wikipedia-org-9224 1433 426 Epsilon Epsilon NNP en-wikipedia-org-9224 1433 427 ( ( -LRB- en-wikipedia-org-9224 1433 428 ε ε NNP en-wikipedia-org-9224 1433 429 ) ) -RRB- en-wikipedia-org-9224 1433 430 FcεRI FcεRI NNP en-wikipedia-org-9224 1433 431 ( ( -LRB- en-wikipedia-org-9224 1433 432 FcεRII FcεRII NNP en-wikipedia-org-9224 1433 433 is be VBZ en-wikipedia-org-9224 1433 434 C c NN en-wikipedia-org-9224 1433 435 - - HYPH en-wikipedia-org-9224 1433 436 type type NN en-wikipedia-org-9224 1433 437 lectin lectin NN en-wikipedia-org-9224 1433 438 ) ) -RRB- en-wikipedia-org-9224 1433 439 Gamma Gamma NNP en-wikipedia-org-9224 1433 440 ( ( -LRB- en-wikipedia-org-9224 1433 441 γ γ NNP en-wikipedia-org-9224 1433 442 ) ) -RRB- en-wikipedia-org-9224 1433 443 FcγRI FcγRI NNP en-wikipedia-org-9224 1433 444 FcγRII FcγRII NNP en-wikipedia-org-9224 1433 445 FcγRIII FcγRIII NNP en-wikipedia-org-9224 1433 446 Neonatal Neonatal NNP en-wikipedia-org-9224 1433 447 Alpha Alpha NNP en-wikipedia-org-9224 1433 448 ( ( -LRB- en-wikipedia-org-9224 1433 449 α)/mu α)/mu NNP en-wikipedia-org-9224 1433 450 ( ( -LRB- en-wikipedia-org-9224 1433 451 μ μ NN en-wikipedia-org-9224 1433 452 ) ) -RRB- en-wikipedia-org-9224 1433 453 FcαRI FcαRI NNP en-wikipedia-org-9224 1433 454 Fcα Fcα NNP en-wikipedia-org-9224 1433 455 / / SYM en-wikipedia-org-9224 1433 456 μR μR NNP en-wikipedia-org-9224 1433 457 Secretory secretory RB en-wikipedia-org-9224 1433 458 Polymeric Polymeric NNP en-wikipedia-org-9224 1433 459 immunoglobulin immunoglobulin NN en-wikipedia-org-9224 1433 460 receptor receptor NN en-wikipedia-org-9224 1433 461 Antigen Antigen NNP en-wikipedia-org-9224 1433 462 receptor receptor NN en-wikipedia-org-9224 1433 463 B B NNP en-wikipedia-org-9224 1433 464 cells cell VBZ en-wikipedia-org-9224 1433 465 Antigen Antigen NNP en-wikipedia-org-9224 1433 466 receptor receptor NN en-wikipedia-org-9224 1433 467 BCR BCR NNP en-wikipedia-org-9224 1433 468 Co Co NNP en-wikipedia-org-9224 1433 469 - - NN en-wikipedia-org-9224 1433 470 receptor receptor NN en-wikipedia-org-9224 1433 471 stimulate stimulate NN en-wikipedia-org-9224 1433 472 : : : en-wikipedia-org-9224 1433 473 CD21 CD21 NNP en-wikipedia-org-9224 1433 474 / / SYM en-wikipedia-org-9224 1433 475 CD19 CD19 NNP en-wikipedia-org-9224 1433 476 / / SYM en-wikipedia-org-9224 1433 477 CD81 CD81 NNP en-wikipedia-org-9224 1433 478 inhibit inhibit NN en-wikipedia-org-9224 1433 479 : : : en-wikipedia-org-9224 1433 480 CD22 CD22 NNP en-wikipedia-org-9224 1433 481 Accessory Accessory NNP en-wikipedia-org-9224 1433 482 molecules molecule VBZ en-wikipedia-org-9224 1433 483 Ig Ig NNP en-wikipedia-org-9224 1433 484 - - HYPH en-wikipedia-org-9224 1433 485 α α NNP en-wikipedia-org-9224 1433 486 / / SYM en-wikipedia-org-9224 1433 487 Ig Ig NNP en-wikipedia-org-9224 1433 488 - - HYPH en-wikipedia-org-9224 1433 489 β β NNP en-wikipedia-org-9224 1433 490 ( ( -LRB- en-wikipedia-org-9224 1433 491 CD79 CD79 NNP en-wikipedia-org-9224 1433 492 ) ) -RRB- en-wikipedia-org-9224 1433 493 T t NN en-wikipedia-org-9224 1433 494 cells cell NNS en-wikipedia-org-9224 1433 495 Ligands ligand VBZ en-wikipedia-org-9224 1433 496 MHC MHC NNP en-wikipedia-org-9224 1433 497 MHC MHC NNP en-wikipedia-org-9224 1433 498 class class NN en-wikipedia-org-9224 1433 499 I -PRON- PRP en-wikipedia-org-9224 1433 500 MHC MHC NNP en-wikipedia-org-9224 1433 501 class class NN en-wikipedia-org-9224 1433 502 II II NNP en-wikipedia-org-9224 1433 503 Antigen Antigen NNP en-wikipedia-org-9224 1433 504 receptor receptor NN en-wikipedia-org-9224 1433 505 TCR TCR NNP en-wikipedia-org-9224 1433 506 : : : en-wikipedia-org-9224 1433 507 TRA@ TRA@ NNP en-wikipedia-org-9224 1433 508 TRB@ trb@ CD en-wikipedia-org-9224 1433 509 TRD@ trd@ CD en-wikipedia-org-9224 1433 510 TRG@ TRG@ . en-wikipedia-org-9224 1433 511 Co co NN en-wikipedia-org-9224 1433 512 - - NNS en-wikipedia-org-9224 1433 513 receptors receptor VBZ en-wikipedia-org-9224 1433 514 CD8 CD8 NNP en-wikipedia-org-9224 1433 515 ( ( -LRB- en-wikipedia-org-9224 1433 516 with with IN en-wikipedia-org-9224 1433 517 two two CD en-wikipedia-org-9224 1433 518 glycoprotein glycoprotein NN en-wikipedia-org-9224 1433 519 chains chain NNS en-wikipedia-org-9224 1433 520 CD8α CD8α NNP en-wikipedia-org-9224 1433 521 and and CC en-wikipedia-org-9224 1433 522 CD8β CD8β NNP en-wikipedia-org-9224 1433 523 ) ) -RRB- en-wikipedia-org-9224 1433 524 CD4 cd4 VBP en-wikipedia-org-9224 1433 525 Accessory accessory NN en-wikipedia-org-9224 1433 526 molecules molecule NNS en-wikipedia-org-9224 1433 527 CD3 CD3 NNP en-wikipedia-org-9224 1433 528 CD3γ cd3γ NN en-wikipedia-org-9224 1433 529 CD3δ cd3δ RB en-wikipedia-org-9224 1433 530 CD3ε CD3ε NNP en-wikipedia-org-9224 1433 531 ζ ζ NN en-wikipedia-org-9224 1433 532 - - HYPH en-wikipedia-org-9224 1433 533 chain chain NN en-wikipedia-org-9224 1433 534 ( ( -LRB- en-wikipedia-org-9224 1433 535 also also RB en-wikipedia-org-9224 1433 536 called call VBN en-wikipedia-org-9224 1433 537 CD3ζ CD3ζ NNP en-wikipedia-org-9224 1433 538 and and CC en-wikipedia-org-9224 1433 539 TCRζ TCRζ NNPS en-wikipedia-org-9224 1433 540 ) ) -RRB- en-wikipedia-org-9224 1433 541 Cytokine cytokine JJ en-wikipedia-org-9224 1433 542 receptor receptor NN en-wikipedia-org-9224 1433 543 see see VBP en-wikipedia-org-9224 1433 544 cytokine cytokine JJ en-wikipedia-org-9224 1433 545 receptors receptor NNS en-wikipedia-org-9224 1433 546 Killer Killer NNP en-wikipedia-org-9224 1433 547 - - HYPH en-wikipedia-org-9224 1433 548 cell cell NN en-wikipedia-org-9224 1433 549 IG IG NNP en-wikipedia-org-9224 1433 550 - - HYPH en-wikipedia-org-9224 1433 551 like like NNP en-wikipedia-org-9224 1433 552 receptors receptor NNS en-wikipedia-org-9224 1433 553 KIR2DL1 KIR2DL1 NNP en-wikipedia-org-9224 1433 554 KIR2DL2 kir2dl2 CD en-wikipedia-org-9224 1433 555 KIR2DL3 kir2dl3 SYM en-wikipedia-org-9224 1433 556 KIR2DL4 kir2dl4 CD en-wikipedia-org-9224 1433 557 KIR2DL5A KIR2DL5A NNP en-wikipedia-org-9224 1433 558 KIR2DL5B KIR2DL5B NNP en-wikipedia-org-9224 1433 559 KIR2DS1 KIR2DS1 NNP en-wikipedia-org-9224 1433 560 KIR2DS2 kir2ds2 CD en-wikipedia-org-9224 1433 561 KIR2DS3 KIR2DS3 NNP en-wikipedia-org-9224 1433 562 KIR2DS4 KIR2DS4 NNP en-wikipedia-org-9224 1433 563 KIR2DS5 kir2ds5 CD en-wikipedia-org-9224 1433 564 KIR3DL1 KIR3DL1 NNP en-wikipedia-org-9224 1433 565 KIR3DL2 kir3dl2 CD en-wikipedia-org-9224 1433 566 KIR3DL3 kir3dl3 CD en-wikipedia-org-9224 1433 567 KIR3DS1 kir3ds1 CD en-wikipedia-org-9224 1433 568 Leukocyte Leukocyte NNP en-wikipedia-org-9224 1433 569 IG IG NNP en-wikipedia-org-9224 1433 570 - - HYPH en-wikipedia-org-9224 1433 571 like like NNP en-wikipedia-org-9224 1433 572 receptors receptor NNS en-wikipedia-org-9224 1433 573 LILRA1 LILRA1 NNP en-wikipedia-org-9224 1433 574 LILRA2 LILRA2 NNP en-wikipedia-org-9224 1433 575 LILRA3 LILRA3 NNP en-wikipedia-org-9224 1433 576 LILRA4 LILRA4 NNP en-wikipedia-org-9224 1433 577 LILRA5 LILRA5 NNP en-wikipedia-org-9224 1433 578 LILRA6 LILRA6 NNP en-wikipedia-org-9224 1433 579 LILRB1 LILRB1 NNP en-wikipedia-org-9224 1433 580 LILRB2 LILRB2 NNP en-wikipedia-org-9224 1433 581 LILRB3 LILRB3 NNP en-wikipedia-org-9224 1433 582 LILRB4 LILRB4 NNP en-wikipedia-org-9224 1433 583 LILRB5 LILRB5 NNP en-wikipedia-org-9224 1433 584 LILRA6 LILRA6 NNP en-wikipedia-org-9224 1433 585 LILRA5 LILRA5 NNP en-wikipedia-org-9224 1433 586 Biology Biology NNP en-wikipedia-org-9224 1433 587 portal portal JJ en-wikipedia-org-9224 1433 588 Medicine Medicine NNP en-wikipedia-org-9224 1433 589 portal portal JJ en-wikipedia-org-9224 1433 590 Viruses Viruses NNP en-wikipedia-org-9224 1433 591 portal portal NNP en-wikipedia-org-9224 1433 592 Authority Authority NNP en-wikipedia-org-9224 1433 593 control control NN en-wikipedia-org-9224 1433 594 GND GND NNP en-wikipedia-org-9224 1433 595 : : : en-wikipedia-org-9224 1433 596 4026643 4026643 CD en-wikipedia-org-9224 1433 597 - - SYM en-wikipedia-org-9224 1433 598 6 6 CD en-wikipedia-org-9224 1433 599 Retrieved retrieve VBN en-wikipedia-org-9224 1433 600 from from IN en-wikipedia-org-9224 1433 601 " " `` en-wikipedia-org-9224 1433 602 https://en.wikipedia.org/w/index.php?title=Immune_system&oldid=994150918 https://en.wikipedia.org/w/index.php?title=Immune_system&oldid=994150918 NNP en-wikipedia-org-9224 1433 603 " " '' en-wikipedia-org-9224 1433 604 Categories Categories NNPS en-wikipedia-org-9224 1433 605 : : : en-wikipedia-org-9224 1433 606 Immune immune JJ en-wikipedia-org-9224 1433 607 system system NN en-wikipedia-org-9224 1433 608 Hidden hide VBN en-wikipedia-org-9224 1433 609 categories category NNS en-wikipedia-org-9224 1433 610 : : : en-wikipedia-org-9224 1433 611 Articles article NNS en-wikipedia-org-9224 1433 612 with with IN en-wikipedia-org-9224 1433 613 short short JJ en-wikipedia-org-9224 1433 614 description description NN en-wikipedia-org-9224 1433 615 Short short JJ en-wikipedia-org-9224 1433 616 description description NN en-wikipedia-org-9224 1433 617 is be VBZ en-wikipedia-org-9224 1433 618 different different JJ en-wikipedia-org-9224 1433 619 from from IN en-wikipedia-org-9224 1433 620 Wikidata Wikidata NNP en-wikipedia-org-9224 1433 621 Wikipedia Wikipedia NNP en-wikipedia-org-9224 1433 622 indefinitely indefinitely RB en-wikipedia-org-9224 1433 623 move move VB en-wikipedia-org-9224 1433 624 - - HYPH en-wikipedia-org-9224 1433 625 protected protect VBN en-wikipedia-org-9224 1433 626 pages page NNS en-wikipedia-org-9224 1433 627 Use Use NNP en-wikipedia-org-9224 1433 628 dmy dmy NN en-wikipedia-org-9224 1433 629 dates date NNS en-wikipedia-org-9224 1433 630 from from IN en-wikipedia-org-9224 1433 631 November November NNP en-wikipedia-org-9224 1433 632 2020 2020 CD en-wikipedia-org-9224 1433 633 Commons Commons NNP en-wikipedia-org-9224 1433 634 category category NN en-wikipedia-org-9224 1433 635 link link NN en-wikipedia-org-9224 1433 636 is be VBZ en-wikipedia-org-9224 1433 637 on on IN en-wikipedia-org-9224 1433 638 Wikidata Wikidata NNP en-wikipedia-org-9224 1433 639 Featured Featured NNP en-wikipedia-org-9224 1433 640 articles article NNS en-wikipedia-org-9224 1433 641 Wikipedia wikipedia JJ en-wikipedia-org-9224 1433 642 articles article NNS en-wikipedia-org-9224 1433 643 with with IN en-wikipedia-org-9224 1433 644 GND GND NNP en-wikipedia-org-9224 1433 645 identifiers identifiers NNPS en-wikipedia-org-9224 1433 646 Navigation Navigation NNP en-wikipedia-org-9224 1433 647 menu menu MD en-wikipedia-org-9224 1433 648 Personal personal JJ en-wikipedia-org-9224 1433 649 tools tool NNS en-wikipedia-org-9224 1433 650 Not not RB en-wikipedia-org-9224 1433 651 logged log VBN en-wikipedia-org-9224 1433 652 in in IN en-wikipedia-org-9224 1433 653 Talk Talk NNP en-wikipedia-org-9224 1433 654 Contributions Contributions NNP en-wikipedia-org-9224 1433 655 Create Create NNP en-wikipedia-org-9224 1433 656 account account NN en-wikipedia-org-9224 1433 657 Log Log NNP en-wikipedia-org-9224 1433 658 in in IN en-wikipedia-org-9224 1433 659 Namespaces Namespaces NNP en-wikipedia-org-9224 1433 660 Article Article NNP en-wikipedia-org-9224 1433 661 Talk talk NN en-wikipedia-org-9224 1433 662 Variants variant VBZ en-wikipedia-org-9224 1433 663 Views view NNS en-wikipedia-org-9224 1433 664 Read read VBP en-wikipedia-org-9224 1433 665 Edit edit NN en-wikipedia-org-9224 1433 666 View View NNP en-wikipedia-org-9224 1433 667 history history NN en-wikipedia-org-9224 1433 668 More More JJR en-wikipedia-org-9224 1433 669 Search Search NNP en-wikipedia-org-9224 1433 670 Navigation Navigation NNP en-wikipedia-org-9224 1433 671 Main Main NNP en-wikipedia-org-9224 1433 672 page page NN en-wikipedia-org-9224 1433 673 Contents content VBZ en-wikipedia-org-9224 1433 674 Current current JJ en-wikipedia-org-9224 1433 675 events event NNS en-wikipedia-org-9224 1433 676 Random random JJ en-wikipedia-org-9224 1433 677 article article NN en-wikipedia-org-9224 1433 678 About about IN en-wikipedia-org-9224 1433 679 Wikipedia Wikipedia NNP en-wikipedia-org-9224 1433 680 Contact Contact NNP en-wikipedia-org-9224 1433 681 us -PRON- PRP en-wikipedia-org-9224 1433 682 Donate Donate NNP en-wikipedia-org-9224 1433 683 Contribute contribute NN en-wikipedia-org-9224 1433 684 Help help NN en-wikipedia-org-9224 1433 685 Learn learn VB en-wikipedia-org-9224 1433 686 to to TO en-wikipedia-org-9224 1433 687 edit edit VB en-wikipedia-org-9224 1433 688 Community community NN en-wikipedia-org-9224 1433 689 portal portal JJ en-wikipedia-org-9224 1433 690 Recent recent JJ en-wikipedia-org-9224 1433 691 changes change NNS en-wikipedia-org-9224 1433 692 Upload upload JJ en-wikipedia-org-9224 1433 693 file file NN en-wikipedia-org-9224 1433 694 Tools tool NNS en-wikipedia-org-9224 1433 695 What what WP en-wikipedia-org-9224 1433 696 links link NNS en-wikipedia-org-9224 1433 697 here here RB en-wikipedia-org-9224 1433 698 Related relate VBN en-wikipedia-org-9224 1433 699 changes change VBZ en-wikipedia-org-9224 1433 700 Upload upload JJ en-wikipedia-org-9224 1433 701 file file VBP en-wikipedia-org-9224 1433 702 Special special JJ en-wikipedia-org-9224 1433 703 pages page NNS en-wikipedia-org-9224 1433 704 Permanent permanent JJ en-wikipedia-org-9224 1433 705 link link NN en-wikipedia-org-9224 1433 706 Page Page NNP en-wikipedia-org-9224 1433 707 information information NN en-wikipedia-org-9224 1433 708 Cite cite VB en-wikipedia-org-9224 1433 709 this this DT en-wikipedia-org-9224 1433 710 page page NN en-wikipedia-org-9224 1433 711 Wikidata wikidata NN en-wikipedia-org-9224 1433 712 item item NN en-wikipedia-org-9224 1433 713 Print print NN en-wikipedia-org-9224 1433 714 / / SYM en-wikipedia-org-9224 1433 715 export export NN en-wikipedia-org-9224 1433 716 Download Download NNP en-wikipedia-org-9224 1433 717 as as IN en-wikipedia-org-9224 1433 718 PDF PDF NNP en-wikipedia-org-9224 1433 719 Printable Printable NNP en-wikipedia-org-9224 1433 720 version version NN en-wikipedia-org-9224 1433 721 In in IN en-wikipedia-org-9224 1433 722 other other JJ en-wikipedia-org-9224 1433 723 projects project NNS en-wikipedia-org-9224 1433 724 Wikimedia Wikimedia NNP en-wikipedia-org-9224 1433 725 Commons Commons NNPS en-wikipedia-org-9224 1433 726 Languages Languages NNPS en-wikipedia-org-9224 1433 727 Afrikaans Afrikaans NNPS en-wikipedia-org-9224 1433 728 Alemannisch Alemannisch NNP en-wikipedia-org-9224 1433 729 العربية العربية NN en-wikipedia-org-9224 1433 730 Aragonés Aragonés NNP en-wikipedia-org-9224 1433 731 অসমীয়া অসমীয়া . en-wikipedia-org-9224 1433 732 Asturianu Asturianu NNP en-wikipedia-org-9224 1433 733 Azərbaycanca Azərbaycanca NNP en-wikipedia-org-9224 1433 734 বাংলা বাংলা NNP en-wikipedia-org-9224 1433 735 Bân bân NN en-wikipedia-org-9224 1433 736 - - HYPH en-wikipedia-org-9224 1433 737 lâm lâm NN en-wikipedia-org-9224 1433 738 - - HYPH en-wikipedia-org-9224 1433 739 gú gú NN en-wikipedia-org-9224 1433 740 Башҡортса Башҡортса NNP en-wikipedia-org-9224 1433 741 Беларуская Беларуская NNP en-wikipedia-org-9224 1433 742 Беларуская Беларуская NNP en-wikipedia-org-9224 1433 743 ( ( -LRB- en-wikipedia-org-9224 1433 744 тарашкевіца)‎ тарашкевіца)‎ NNP en-wikipedia-org-9224 1433 745 भोजपुरी भोजपुरी NNP en-wikipedia-org-9224 1433 746 Български Български NNP en-wikipedia-org-9224 1433 747 Bosanski Bosanski NNP en-wikipedia-org-9224 1433 748 Català Català NNP en-wikipedia-org-9224 1433 749 Чӑвашла Чӑвашла NNP en-wikipedia-org-9224 1433 750 Čeština Čeština NNP en-wikipedia-org-9224 1433 751 Cymraeg Cymraeg NNP en-wikipedia-org-9224 1433 752 Dansk Dansk NNP en-wikipedia-org-9224 1433 753 Davvisámegiella Davvisámegiella NNP en-wikipedia-org-9224 1433 754 Deutsch Deutsch NNP en-wikipedia-org-9224 1433 755 Eesti Eesti NNP en-wikipedia-org-9224 1433 756 Ελληνικά Ελληνικά NNP en-wikipedia-org-9224 1433 757 Español Español NNP en-wikipedia-org-9224 1433 758 Esperanto Esperanto NNP en-wikipedia-org-9224 1433 759 Euskara Euskara NNP en-wikipedia-org-9224 1433 760 فارسی فارسی JJ en-wikipedia-org-9224 1433 761 Føroyskt Føroyskt NNP en-wikipedia-org-9224 1433 762 Français Français NNP en-wikipedia-org-9224 1433 763 Gaeilge Gaeilge NNP en-wikipedia-org-9224 1433 764 Galego Galego NNP en-wikipedia-org-9224 1433 765 客家語 客家語 NNP en-wikipedia-org-9224 1433 766 / / SYM en-wikipedia-org-9224 1433 767 Hak Hak NNP en-wikipedia-org-9224 1433 768 - - HYPH en-wikipedia-org-9224 1433 769 kâ kâ NNP en-wikipedia-org-9224 1433 770 - - HYPH en-wikipedia-org-9224 1433 771 ngî ngî NNP en-wikipedia-org-9224 1433 772 한국어 한국어 NN en-wikipedia-org-9224 1433 773 Հայերեն Հայերեն NNP en-wikipedia-org-9224 1433 774 हिन्दी हिन्दी NNS en-wikipedia-org-9224 1433 775 Hrvatski Hrvatski NNP en-wikipedia-org-9224 1433 776 Ilokano Ilokano NNP en-wikipedia-org-9224 1433 777 Bahasa Bahasa NNP en-wikipedia-org-9224 1433 778 Indonesia Indonesia NNP en-wikipedia-org-9224 1433 779 Íslenska Íslenska NNP en-wikipedia-org-9224 1433 780 Italiano Italiano NNP en-wikipedia-org-9224 1433 781 עברית עברית NN en-wikipedia-org-9224 1433 782 Jawa Jawa NNP en-wikipedia-org-9224 1433 783 ಕನ್ನಡ ಕನ್ನಡ XX en-wikipedia-org-9224 1433 784 Kapampangan Kapampangan NNP en-wikipedia-org-9224 1433 785 ქართული ქართული NN en-wikipedia-org-9224 1433 786 Қазақша Қазақша NNP en-wikipedia-org-9224 1433 787 Kiswahili Kiswahili NNP en-wikipedia-org-9224 1433 788 Kreyòl Kreyòl NNP en-wikipedia-org-9224 1433 789 ayisyen ayisyen NN en-wikipedia-org-9224 1433 790 Kriyòl Kriyòl NNP en-wikipedia-org-9224 1433 791 gwiyannen gwiyannen FW en-wikipedia-org-9224 1433 792 Latina Latina NNP en-wikipedia-org-9224 1433 793 Latviešu Latviešu NNP en-wikipedia-org-9224 1433 794 Lietuvių Lietuvių NNP en-wikipedia-org-9224 1433 795 Luganda Luganda NNP en-wikipedia-org-9224 1433 796 Magyar Magyar NNP en-wikipedia-org-9224 1433 797 Македонски Македонски NNP en-wikipedia-org-9224 1433 798 മലയാളം മലയാളം . en-wikipedia-org-9224 1433 799 ဘာသာ ဘာသာ NFP en-wikipedia-org-9224 1433 800 မန် မန် NFP en-wikipedia-org-9224 1433 801 Bahasa Bahasa NNP en-wikipedia-org-9224 1433 802 Melayu Melayu NNP en-wikipedia-org-9224 1433 803 Na Na NNP en-wikipedia-org-9224 1433 804 Vosa Vosa NNP en-wikipedia-org-9224 1433 805 Vakaviti Vakaviti NNP en-wikipedia-org-9224 1433 806 Nederlands Nederlands NNP en-wikipedia-org-9224 1433 807 नेपाली नेपाली NNP en-wikipedia-org-9224 1433 808 नेपाल नेपाल NN en-wikipedia-org-9224 1433 809 भाषा भाषा VBZ en-wikipedia-org-9224 1433 810 日本語 日本語 NNP en-wikipedia-org-9224 1433 811 Norsk Norsk NNP en-wikipedia-org-9224 1433 812 bokmål bokmål NN en-wikipedia-org-9224 1433 813 Norsk Norsk NNP en-wikipedia-org-9224 1433 814 nynorsk nynorsk NNP en-wikipedia-org-9224 1433 815 Occitan Occitan NNP en-wikipedia-org-9224 1433 816 ਪੰਜਾਬੀ ਪੰਜਾਬੀ NNP en-wikipedia-org-9224 1433 817 پنجابی پنجابی JJ en-wikipedia-org-9224 1433 818 Patois Patois NNP en-wikipedia-org-9224 1433 819 Polski Polski NNP en-wikipedia-org-9224 1433 820 Português Português NNP en-wikipedia-org-9224 1433 821 Română Română NNP en-wikipedia-org-9224 1433 822 Runa Runa NNP en-wikipedia-org-9224 1433 823 Simi Simi NNP en-wikipedia-org-9224 1433 824 Русиньскый Русиньскый NNP en-wikipedia-org-9224 1433 825 Русский Русский NNP en-wikipedia-org-9224 1433 826 Shqip Shqip NNP en-wikipedia-org-9224 1433 827 සිංහල සිංහල NNP en-wikipedia-org-9224 1433 828 Simple simple JJ en-wikipedia-org-9224 1433 829 English English NNP en-wikipedia-org-9224 1433 830 Slovenčina Slovenčina NNP en-wikipedia-org-9224 1433 831 Slovenščina Slovenščina NNP en-wikipedia-org-9224 1433 832 کوردی کوردی NN en-wikipedia-org-9224 1433 833 Српски Српски NNP en-wikipedia-org-9224 1433 834 / / SYM en-wikipedia-org-9224 1433 835 srpski srpski JJ en-wikipedia-org-9224 1433 836 Srpskohrvatski Srpskohrvatski NNP en-wikipedia-org-9224 1433 837 / / SYM en-wikipedia-org-9224 1433 838 српскохрватски српскохрватски JJ en-wikipedia-org-9224 1433 839 Sunda Sunda NNP en-wikipedia-org-9224 1433 840 Suomi Suomi NNP en-wikipedia-org-9224 1433 841 Svenska Svenska NNP en-wikipedia-org-9224 1433 842 Tagalog Tagalog NNP en-wikipedia-org-9224 1433 843 தமிழ் தமிழ் , en-wikipedia-org-9224 1433 844 తెలుగు తెలుగు NN en-wikipedia-org-9224 1433 845 ไทย ไทย NNP en-wikipedia-org-9224 1433 846 Türkçe Türkçe NNP en-wikipedia-org-9224 1433 847 Українська Українська NNP en-wikipedia-org-9224 1433 848 اردو اردو NN en-wikipedia-org-9224 1433 849 Tiếng Tiếng NNP en-wikipedia-org-9224 1433 850 Việt Việt NNP en-wikipedia-org-9224 1433 851 Winaray Winaray NNP en-wikipedia-org-9224 1433 852 吴语 吴语 DT en-wikipedia-org-9224 1433 853 ייִדיש ייִדיש NNP en-wikipedia-org-9224 1433 854 粵語 粵語 IN en-wikipedia-org-9224 1433 855 中文 中文 NNP en-wikipedia-org-9224 1433 856 Edit Edit NNP en-wikipedia-org-9224 1433 857 links link NNS en-wikipedia-org-9224 1433 858 This this DT en-wikipedia-org-9224 1433 859 page page NN en-wikipedia-org-9224 1433 860 was be VBD en-wikipedia-org-9224 1433 861 last last RB en-wikipedia-org-9224 1433 862 edited edit VBN en-wikipedia-org-9224 1433 863 on on IN en-wikipedia-org-9224 1433 864 14 14 CD en-wikipedia-org-9224 1433 865 December December NNP en-wikipedia-org-9224 1433 866 2020 2020 CD en-wikipedia-org-9224 1433 867 , , , en-wikipedia-org-9224 1433 868 at at IN en-wikipedia-org-9224 1433 869 09:21 09:21 CD en-wikipedia-org-9224 1433 870   _SP en-wikipedia-org-9224 1433 871 ( ( -LRB- en-wikipedia-org-9224 1433 872 UTC UTC NNP en-wikipedia-org-9224 1433 873 ) ) -RRB- en-wikipedia-org-9224 1433 874 . . . en-wikipedia-org-9224 1434 1 Text text NN en-wikipedia-org-9224 1434 2 is be VBZ en-wikipedia-org-9224 1434 3 available available JJ en-wikipedia-org-9224 1434 4 under under IN en-wikipedia-org-9224 1434 5 the the DT en-wikipedia-org-9224 1434 6 Creative Creative NNP en-wikipedia-org-9224 1434 7 Commons Commons NNP en-wikipedia-org-9224 1434 8 Attribution Attribution NNP en-wikipedia-org-9224 1434 9 - - HYPH en-wikipedia-org-9224 1434 10 ShareAlike ShareAlike NNP en-wikipedia-org-9224 1434 11 License License NNP en-wikipedia-org-9224 1434 12 ; ; , en-wikipedia-org-9224 1434 13 additional additional JJ en-wikipedia-org-9224 1434 14 terms term NNS en-wikipedia-org-9224 1434 15 may may MD en-wikipedia-org-9224 1434 16 apply apply VB en-wikipedia-org-9224 1434 17 . . . en-wikipedia-org-9224 1435 1 By by IN en-wikipedia-org-9224 1435 2 using use VBG en-wikipedia-org-9224 1435 3 this this DT en-wikipedia-org-9224 1435 4 site site NN en-wikipedia-org-9224 1435 5 , , , en-wikipedia-org-9224 1435 6 you -PRON- PRP en-wikipedia-org-9224 1435 7 agree agree VBP en-wikipedia-org-9224 1435 8 to to IN en-wikipedia-org-9224 1435 9 the the DT en-wikipedia-org-9224 1435 10 Terms term NNS en-wikipedia-org-9224 1435 11 of of IN en-wikipedia-org-9224 1435 12 Use Use NNP en-wikipedia-org-9224 1435 13 and and CC en-wikipedia-org-9224 1435 14 Privacy Privacy NNP en-wikipedia-org-9224 1435 15 Policy Policy NNP en-wikipedia-org-9224 1435 16 . . . en-wikipedia-org-9224 1436 1 Wikipedia Wikipedia NNP en-wikipedia-org-9224 1436 2 ® ® NNPS en-wikipedia-org-9224 1436 3 is be VBZ en-wikipedia-org-9224 1436 4 a a DT en-wikipedia-org-9224 1436 5 registered registered JJ en-wikipedia-org-9224 1436 6 trademark trademark NN en-wikipedia-org-9224 1436 7 of of IN en-wikipedia-org-9224 1436 8 the the DT en-wikipedia-org-9224 1436 9 Wikimedia Wikimedia NNP en-wikipedia-org-9224 1436 10 Foundation Foundation NNP en-wikipedia-org-9224 1436 11 , , , en-wikipedia-org-9224 1436 12 Inc. 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