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[The Antonine plague] [Article in French] Charles Haas PMID: 17195627 Item in Clipboard [The Antonine plague] [Article in French] Charles Haas. Bull Acad Natl Med. Apr-May 2006. Show details Display options Display options Format Abstract PubMed PMID Bull Acad Natl Med Actions Search in PubMed Search in NLM Catalog Add to Search . Apr-May 2006;190(4-5):1093-8. Author Charles Haas PMID: 17195627 Item in Clipboard CiteDisplay options Display options Format Abstract PubMed PMID Abstract During the reign of Marcus Aurelius, the Roman Empire was struck by a long and destructive epidemic. It began in Mesopotamia in late AD 165 or early AD 166 during Verus' Parthian campaign, and quickly spread to Rome. It lasted at least until the death of Marcus Aurelius in AD 180 and likely into the early part of Commodus' reign. Its victims were "innumerable". Galen had first-hand knowledge of the disease. He was in Rome when the plague reached the city in AD 166. He was also present during an outbreak among troops stationed at Aquileia during the winter of AD 168-169. His references to the plague are scattered and brief but enough information is available to firmly identify the plague as smallpox. His description of the exanthema is fairly typical of the smallpox rash, particularly in the hemorrhagic phase of the disease. Cited by 1 article Yersinia pestis: the Natural History of Plague. Barbieri R, Signoli M, Chevé D, Costedoat C, Tzortzis S, Aboudharam G, Raoult D, Drancourt M. Barbieri R, et al. Clin Microbiol Rev. 2020 Dec 9;34(1):e00044-19. doi: 10.1128/CMR.00044-19. Print 2020 Dec 16. Clin Microbiol Rev. 2020. PMID: 33298527 Review. 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