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Oxytocin increases trust in humans Michael Kosfeld  1 , Markus Heinrichs, Paul J Zak, Urs Fischbacher, Ernst Fehr Affiliations Expand Affiliation 1 University of Zurich, Institute for Empirical Research in Economics, Blumlisalpstrasse 10, CH-8006 Zurich, Switzerland. PMID: 15931222 DOI: 10.1038/nature03701 Item in Clipboard Clinical Trial Oxytocin increases trust in humans Michael Kosfeld et al. Nature. 2005. Show details Display options Display options Format Abstract PubMed PMID Nature Actions Search in PubMed Search in NLM Catalog Add to Search . 2005 Jun 2;435(7042):673-6. doi: 10.1038/nature03701. Authors Michael Kosfeld  1 , Markus Heinrichs, Paul J Zak, Urs Fischbacher, Ernst Fehr Affiliation 1 University of Zurich, Institute for Empirical Research in Economics, Blumlisalpstrasse 10, CH-8006 Zurich, Switzerland. PMID: 15931222 DOI: 10.1038/nature03701 Item in Clipboard Full-text links CiteDisplay options Display options Format Abstract PubMed PMID Abstract Trust pervades human societies. Trust is indispensable in friendship, love, families and organizations, and plays a key role in economic exchange and politics. In the absence of trust among trading partners, market transactions break down. In the absence of trust in a country's institutions and leaders, political legitimacy breaks down. Much recent evidence indicates that trust contributes to economic, political and social success. Little is known, however, about the biological basis of trust among humans. Here we show that intranasal administration of oxytocin, a neuropeptide that plays a key role in social attachment and affiliation in non-human mammals, causes a substantial increase in trust among humans, thereby greatly increasing the benefits from social interactions. We also show that the effect of oxytocin on trust is not due to a general increase in the readiness to bear risks. On the contrary, oxytocin specifically affects an individual's willingness to accept social risks arising through interpersonal interactions. These results concur with animal research suggesting an essential role for oxytocin as a biological basis of prosocial approach behaviour. Comment in Human behaviour: brain trust. Damasio A. Damasio A. Nature. 2005 Jun 2;435(7042):571-2. doi: 10.1038/435571a. Nature. 2005. PMID: 15931200 No abstract available. [The brain and liberty]. Kiefer B. Kiefer B. Rev Med Suisse. 2005 Jun 8;1(23):1592. Rev Med Suisse. 2005. PMID: 16044807 French. No abstract available. Similar articles Human behaviour: brain trust. Damasio A. Damasio A. Nature. 2005 Jun 2;435(7042):571-2. doi: 10.1038/435571a. Nature. 2005. PMID: 15931200 No abstract available. Oxytocin shapes the neural circuitry of trust and trust adaptation in humans. Baumgartner T, Heinrichs M, Vonlanthen A, Fischbacher U, Fehr E. Baumgartner T, et al. Neuron. 2008 May 22;58(4):639-50. doi: 10.1016/j.neuron.2008.04.009. Neuron. 2008. PMID: 18498743 Clinical Trial. Oxytocin and social perception: oxytocin increases perceived facial trustworthiness and attractiveness. Theodoridou A, Rowe AC, Penton-Voak IS, Rogers PJ. Theodoridou A, et al. Horm Behav. 2009 Jun;56(1):128-32. doi: 10.1016/j.yhbeh.2009.03.019. Epub 2009 Apr 1. Horm Behav. 2009. PMID: 19344725 Impact of prosocial neuropeptides on human brain function. Meyer-Lindenberg A. Meyer-Lindenberg A. Prog Brain Res. 2008;170:463-70. doi: 10.1016/S0079-6123(08)00436-6. Prog Brain Res. 2008. PMID: 18655902 Review. Does Oxytocin Increase Trust in Humans? A Critical Review of Research. Nave G, Camerer C, McCullough M. Nave G, et al. Perspect Psychol Sci. 2015 Nov;10(6):772-89. doi: 10.1177/1745691615600138. Perspect Psychol Sci. 2015. PMID: 26581735 Review. See all similar articles Cited by 700 articles Increasing prosocial behavior and decreasing selfishness in the lab and everyday life. Gloster AT, Rinner MTB, Meyer AH. Gloster AT, et al. Sci Rep. 2020 Dec 4;10(1):21220. doi: 10.1038/s41598-020-78251-z. Sci Rep. 2020. PMID: 33277579 Free PMC article. Plasma Oxytocin Concentrations During and After Gestation in Japanese Pregnant Women Affected by Anxiety Disorder and Endometriosis. Masumoto T, Onishi K, Harada T, Amano H, Otani S, Kurozawa Y. Masumoto T, et al. Yonago Acta Med. 2020 Nov 5;63(4):301-307. doi: 10.33160/yam.2020.11.012. eCollection 2020 Nov. Yonago Acta Med. 2020. PMID: 33253338 Free PMC article. The Influence of an Attachment-Related Stimulus on Oxytocin Reactivity in Poly-Drug Users Undergoing Maintenance Therapy Compared to Healthy Controls. Fuchshuber J, Tatzer J, Hiebler-Ragger M, Trinkl F, Kimmerle A, Rinner A, Buchheim A, Schrom S, Rinner B, Leber K, Pieber T, Weiss E, Lewis AJ, Kapfhammer HP, Unterrainer HF. Fuchshuber J, et al. Front Psychiatry. 2020 Sep 25;11:460506. doi: 10.3389/fpsyt.2020.460506. eCollection 2020. Front Psychiatry. 2020. PMID: 33101071 Free PMC article. Social Feedback During Sensorimotor Synchronization Changes Salivary Oxytocin and Behavioral States. Papasteri CC, Sofonea A, Boldasu R, Poalelungi C, Tomescu MI, Pistol CAD, Vasilescu RI, Nedelcea C, Podina IR, Berceanu AI, Froemke RC, Carcea I. Papasteri CC, et al. Front Psychol. 2020 Sep 23;11:531046. doi: 10.3389/fpsyg.2020.531046. eCollection 2020. Front Psychol. 2020. PMID: 33071856 Free PMC article. Brain substrates explain differences in the adoption and degree of financial digitalization. Carbo-Valverde S, Lacomba-Arias JA, Lagos-García FM, Rodriguez-Fernandez F, Verdejo-Román J. Carbo-Valverde S, et al. Sci Rep. 2020 Oct 15;10(1):17512. doi: 10.1038/s41598-020-74554-3. Sci Rep. 2020. PMID: 33060709 Free PMC article. 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