id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_624qrp646zf4pdga57ub3qks2i	Nadia Cobo-Vuilleumier	PARP-1 and cytokine-mediated β-cell damage: a nick in the Okamoto model?	2012	2	.pdf	application/pdf	2154	159	57	PARP-1 and cytokine-mediated �-cell damage: a nick in the Okamoto model? PARP-1 and cytokine-mediated �-cell damage: a nick in the Okamoto model? Pancreatic Islet Development and Regeneration Unit, Department of Stem Cells, CABIMER-Andalusian Center for Molecular Cytokine-mediated cell death proceeds through necrosis or apoptosis and shown that mice lacking PARP-1 were resistant to STZmediated �-cell death and to development of hyperglycemia well does the STZ-induced �-cell death model mimic T1DM? Okamoto model, its role in cytokine-mediated cell death remains to be fully explored. not alter IL-1/IFN-�-mediated phosphorylation of Stat-1, indicating that the Jak/Stat signaling pathway implicated in apoptosis is activated by cytokines in PARP-1-deficient islets (4). islets lacking PARP-1 are resistant to cytokine-mediated cytotoxicity, whereas they remain sensitive to the general apoptotic contrast to STZ-mediated cell death and the Okamoto model, PARP-1 does not contribute to cytokine-induced �-cell damage. repair STZ-mediated DNA damage in PARP-1 knockout mice, Cytokine-mediated �-cell damage in PARP-1-deficient islets.	./cache/work_624qrp646zf4pdga57ub3qks2i.pdf	./txt/work_624qrp646zf4pdga57ub3qks2i.txt