id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_bcu65qz5zbg4lo6bhxih66rfiu	Adem Kalender	A matter of energy stress: p38β meets mTORC1	2011	3	.pdf	application/pdf	1947	155	54	crisis, cells suppress energy consuming anabolic processes and up-regulate that acute mTORC1 inhibition by energy deprivation, can be regulated independently of AMPK through the Rag and inhibition of mTORC1 signaling and inhibition of mTORC1 signaling whether p38 regulates mTORC1, following an energy deprivation episode. The authors then demonstrated that these effects were mediated by p38β-activated kinase PRAK. that ectopic expression of PRAK inhibited mTORC1 in the absence of TSC2, note that 2-DG-induced mTORC1 inhibition is impaired in TSC2 knockout to inhibit mTORC1 in PRAK knockout have shown that AICAR, but not glycolytic or mitochondrial respiratory inhibitors, suppresses mTORC1 signaling in How does PRAK inhibit mTORC1 found that ectopic expression of PRAK inhibited mTORC1 PRAK negatively regulated Rheb function, and following 2-DG treatment, this settings to inhibit mTORC1 signaling. of mTORC1 signaling in a TSC2to down-regulate mTORC1 signaling roles of p38 are involved in regulating mTORC1 function. mTORC1 signaling by energy levels 	./cache/work_bcu65qz5zbg4lo6bhxih66rfiu.pdf	./txt/work_bcu65qz5zbg4lo6bhxih66rfiu.txt