id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_mx2qellqbfbvhd32ao5o5yu3fu	William Mair	Tipping the Energy Balance toward Longevity	2013	2	.pdf	application/pdf	1455	116	59	AMPK is a cellular energy sensor conserved across eukaryotes that in C. Stenesen and colleagues (2012) activate AMPK both directly and indirectly by altering AMP biosynthesis to slow aging in Drosophila, highlighting AMPK as a conserved life span modulator For an organism to survive, it must maintain energy homeostasis by tightly regulating the balance between anabolic multiple genes involved in AMP biosynthesis, and in each case they saw life AMP-activated protein kinase (AMPK), activated during energy limiting conditions known to extend life span, and its in AMP::ATP ratios, AMPK activity was increased AMPK activity is sufficient for Tipping the Energy Balance: Mutations in AMP Biosynthesis Pathways Increase the AMP::ATP Ratio to Increase Longevity AMP::ATP ratios are increased, promoting longevity via activation of AMPK. AMPK can increase life span in fruit flies, not, suggests that either feeding Metformin does not activate AMPK in the relevant tissues for life span extension in	./cache/work_mx2qellqbfbvhd32ao5o5yu3fu.pdf	./txt/work_mx2qellqbfbvhd32ao5o5yu3fu.txt