id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_ngbsarj2wbg7ro3cucswgv3slm	Karissa Barthelson	No observed effect on brain vasculature of Alzheimer's disease-related mutations in the zebrafish presenilin 1 gene	2021	4	.pdf	application/pdf	2229	257	57	Previously, we found that brains of adult zebrafish heterozygous for Alzheimer's disease-related mutations in their presenilin 1 gene (psen1, orthologous to human PSEN1) show greater basal expression levels of hypoxia responsive genes Single zebrafish heterozygous for either psen1 mutation were mated with single fish bearing the fli1::GFP to form families of siblings either wild type or heterozygous for the psen1 mutant alleles (Fig. 1a). EOfAD: Early-onset familial Alzheimer's disease; HIF1: Hypoxia-inducible factor Fig. 1 No statistically significant changes to brain vascular network parameters due to heterozygosity for the Q96_K97del or K97Gfs mutations of a familial Alzheimer's disease-like mutation in the zebrafish presenilin 1 Age-related vascular pathology in transgenic mice expressing presenilin 1-associated familial Alzheimer's disease mutations. No observed effect on brain vasculature of Alzheimer's disease-related mutations in the zebrafish presenilin 1 gene No observed effect on brain vasculature of Alzheimer's disease-related mutations in the zebrafish presenilin 1 gene	./cache/work_ngbsarj2wbg7ro3cucswgv3slm.pdf	./txt/work_ngbsarj2wbg7ro3cucswgv3slm.txt