id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_njvq6rxiybgrpdqcmkyokjtucm	Cynthia Ju	Damage-associated molecular patterns: Their impact on the liver and beyond during acetaminophen overdose	2012	3	.pdf	application/pdf	2319	243	54	and release cytokines and cheomokines, thereby causing tissue sterile inflammation.12-22 The soluble products of innate immune cells can exacerbate tissue damage, as well as promote wound healing (Fig. 1). Three experimental approaches were employed to elucidate the pathological role of neutrophils in AILI. demonstrate that liver injury initiated by APAP challenge is amplified by infiltrating neutrophils. Abbreviations: AILI, APAP-induced liver injury; APAP, acetaminophen; effect of mtDNA release on AILI is revealed by a significant decrease of liver injury in TLR-9�/� mice, model for APAP-induced liver damage and lung causes the release of mitochondrial DAMPs and chemokines, which lead to hepatic recruitment of neutrophils that amplify liver damage. into the liver are not activated,33 (2) blocking neutrophil recruitment does not affect AILI,33,34 and (3) even molecular pattern molecules in acetaminophen-induced liver injury in Chemokines and mitochondrial products activate neutrophils to amplify organ injury during mouse acute liver failure. acetaminophen-induced acute liver injury.	./cache/work_njvq6rxiybgrpdqcmkyokjtucm.pdf	./txt/work_njvq6rxiybgrpdqcmkyokjtucm.txt