id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_pwurzwpjwzaedphampe7sh5wny	Sheng Fong	Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model	2016	10	.pdf	application/pdf	5837	584	52	full length Aβ 1–42 sequence and showed that the fragment size obtained from the Aβ -expressing nematodes corresponds to that of the human Aβ 1–42 minigene (Fig. 1b). Aβ-expressing nematodes displayed neuromuscular defects and middle-aged onset of behavioural We further observed numerous signs of neuromuscular defects in the Aβ -expressing nematodes, including higher incidence of internal hatching (bagging10; Fig. 2a), defects in defecation that lead to constipation (Fig. 2b), lower rates of pharyngeal pumping (Fig. 2c), and abnormal head shake behaviour (Fig. 2d,e). a significant difference in this measurement of head shake behaviour in middle-aged Aβ -expressing nematodes The sequence of events suggests that global metabolic failure in Aβ -expressing nematodes is driven by mitochondrial bioenergetic deficits and progressive complex I and IV dysfunctions. Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model Energy crisis precedes global metabolic failure in a novel Caenorhabditis elegans Alzheimer Disease model	./cache/work_pwurzwpjwzaedphampe7sh5wny.pdf	./txt/work_pwurzwpjwzaedphampe7sh5wny.txt