id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_xqxptcqvjbe2xbji56gfr4b2im	Icksoo Lee	Energy crisis: The role of oxidative phosphorylation in acute inflammation and sepsis	2014	8	.pdf	application/pdf	10541	1287	39	(COX) and cytochrome c, the latter of which plays a central role in apoptosis in addition to mitochondrial respiration, serve as examples for the entire OxPhos system since they have been studied in more detail with respect state of mitochondrial proteins, including Tyr304 phosphorylation of COX catalytic subunit I. Inflammatory responses are key for the outcome of sepsis and may affect cellular function at a very basic level, i.e., the mitochondrial OxPhos this and the following sections, we develop a model (Fig. 1), in which inflammatory signaling leads to the inhibition of COX via tyrosine phosphorylation followed by the depolarization of the mitochondrial Early during septic shock using the CLP model, rat liver mitochondria showed significantly reduced mitochondrial respiration Taken together, these studies suggest that mitochondrial dysfunction via a decrease of OxPhos function and an increase in apoptotic activity in selected cell types may contribute to the septic phenotype.	./cache/work_xqxptcqvjbe2xbji56gfr4b2im.pdf	./txt/work_xqxptcqvjbe2xbji56gfr4b2im.txt