id	sid	tid	token	lemma	pos
work_624qrp646zf4pdga57ub3qks2i	1	1	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	1	2	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	1	3	cytokine	cytokine	NN
work_624qrp646zf4pdga57ub3qks2i	1	4	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	1	5	mediated	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	1	6	β	β	NN
work_624qrp646zf4pdga57ub3qks2i	1	7	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	1	8	cell	cell	NN
work_624qrp646zf4pdga57ub3qks2i	1	9	damage	damage	NN
work_624qrp646zf4pdga57ub3qks2i	1	10	:	:	:
work_624qrp646zf4pdga57ub3qks2i	1	11	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	1	12	nick	nick	NN
work_624qrp646zf4pdga57ub3qks2i	1	13	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	1	14	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	1	15	Okamoto	Okamoto	NNP
work_624qrp646zf4pdga57ub3qks2i	1	16	model	model	NN
work_624qrp646zf4pdga57ub3qks2i	1	17	?	?	.
work_624qrp646zf4pdga57ub3qks2i	2	1	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	2	2	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	2	3	cytokine	cytokine	NN
work_624qrp646zf4pdga57ub3qks2i	2	4	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	2	5	mediated	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	2	6	�	�	JJ
work_624qrp646zf4pdga57ub3qks2i	2	7	-cell	-cell	HYPH
work_624qrp646zf4pdga57ub3qks2i	2	8	damage	damage	NN
work_624qrp646zf4pdga57ub3qks2i	2	9	:	:	:
work_624qrp646zf4pdga57ub3qks2i	2	10	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	2	11	nick	nick	NN
work_624qrp646zf4pdga57ub3qks2i	2	12	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	2	13	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	2	14	Okamoto	Okamoto	NNP
work_624qrp646zf4pdga57ub3qks2i	2	15	model	model	NN
work_624qrp646zf4pdga57ub3qks2i	2	16	?	?	.
work_624qrp646zf4pdga57ub3qks2i	3	1	Nadia	Nadia	NNP
work_624qrp646zf4pdga57ub3qks2i	3	2	Cobo	Cobo	NNP
work_624qrp646zf4pdga57ub3qks2i	3	3	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	3	4	Vuilleumier	Vuilleumier	NNP
work_624qrp646zf4pdga57ub3qks2i	3	5	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	3	6	Benoit	Benoit	NNP
work_624qrp646zf4pdga57ub3qks2i	3	7	R.	R.	NNP
work_624qrp646zf4pdga57ub3qks2i	3	8	Gauthier	Gauthier	NNP
work_624qrp646zf4pdga57ub3qks2i	3	9	Pancreatic	Pancreatic	NNP
work_624qrp646zf4pdga57ub3qks2i	3	10	Islet	Islet	NNP
work_624qrp646zf4pdga57ub3qks2i	3	11	Development	Development	NNP
work_624qrp646zf4pdga57ub3qks2i	3	12	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	3	13	Regeneration	Regeneration	NNP
work_624qrp646zf4pdga57ub3qks2i	3	14	Unit	Unit	NNP
work_624qrp646zf4pdga57ub3qks2i	3	15	,	,	,
work_624qrp646zf4pdga57ub3qks2i	3	16	Department	Department	NNP
work_624qrp646zf4pdga57ub3qks2i	3	17	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	3	18	Stem	Stem	NNP
work_624qrp646zf4pdga57ub3qks2i	3	19	Cells	Cells	NNPS
work_624qrp646zf4pdga57ub3qks2i	3	20	,	,	,
work_624qrp646zf4pdga57ub3qks2i	3	21	CABIMER	CABIMER	NNP
work_624qrp646zf4pdga57ub3qks2i	3	22	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	3	23	Andalusian	Andalusian	NNP
work_624qrp646zf4pdga57ub3qks2i	3	24	Center	Center	NNP
work_624qrp646zf4pdga57ub3qks2i	3	25	for	for	IN
work_624qrp646zf4pdga57ub3qks2i	3	26	Molecular	Molecular	NNP
work_624qrp646zf4pdga57ub3qks2i	3	27	Biology	Biology	NNP
work_624qrp646zf4pdga57ub3qks2i	3	28	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	3	29	Regenerative	Regenerative	NNP
work_624qrp646zf4pdga57ub3qks2i	3	30	Medicine	Medicine	NNP
work_624qrp646zf4pdga57ub3qks2i	3	31	,	,	,
work_624qrp646zf4pdga57ub3qks2i	3	32	Seville	Seville	NNP
work_624qrp646zf4pdga57ub3qks2i	3	33	,	,	,
work_624qrp646zf4pdga57ub3qks2i	3	34	Spain	Spain	NNP
work_624qrp646zf4pdga57ub3qks2i	3	35	Submitted	submit	VBD
work_624qrp646zf4pdga57ub3qks2i	3	36	7	7	CD
work_624qrp646zf4pdga57ub3qks2i	3	37	May	May	NNP
work_624qrp646zf4pdga57ub3qks2i	3	38	2012	2012	CD
work_624qrp646zf4pdga57ub3qks2i	3	39	;	;	:
work_624qrp646zf4pdga57ub3qks2i	3	40	accepted	accept	VBN
work_624qrp646zf4pdga57ub3qks2i	3	41	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	3	42	final	final	JJ
work_624qrp646zf4pdga57ub3qks2i	3	43	form	form	NN
work_624qrp646zf4pdga57ub3qks2i	3	44	7	7	CD
work_624qrp646zf4pdga57ub3qks2i	3	45	May	May	NNP
work_624qrp646zf4pdga57ub3qks2i	3	46	2012	2012	CD
work_624qrp646zf4pdga57ub3qks2i	3	47	TYPE	TYPE	NNP
work_624qrp646zf4pdga57ub3qks2i	3	48	1	1	CD
work_624qrp646zf4pdga57ub3qks2i	3	49	DIABETES	diabetes	NN
work_624qrp646zf4pdga57ub3qks2i	3	50	MELLITUS	MELLITUS	NNP
work_624qrp646zf4pdga57ub3qks2i	3	51	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	3	52	T1DM	T1DM	NNP
work_624qrp646zf4pdga57ub3qks2i	3	53	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	3	54	,	,	,
work_624qrp646zf4pdga57ub3qks2i	3	55	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	3	56	complex	complex	JJ
work_624qrp646zf4pdga57ub3qks2i	3	57	genetic	genetic	JJ
work_624qrp646zf4pdga57ub3qks2i	3	58	disease	disease	NN
work_624qrp646zf4pdga57ub3qks2i	3	59	characterized	characterize	VBN
work_624qrp646zf4pdga57ub3qks2i	3	60	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	3	61	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	3	62	destruction	destruction	NN
work_624qrp646zf4pdga57ub3qks2i	3	63	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	3	64	pancreatic	pancreatic	JJ
work_624qrp646zf4pdga57ub3qks2i	3	65	islet	islet	NN
work_624qrp646zf4pdga57ub3qks2i	3	66	�	�	,
work_624qrp646zf4pdga57ub3qks2i	3	67	-cells	-cells	,
work_624qrp646zf4pdga57ub3qks2i	3	68	,	,	,
work_624qrp646zf4pdga57ub3qks2i	3	69	leads	lead	VBZ
work_624qrp646zf4pdga57ub3qks2i	3	70	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	3	71	insulin	insulin	VB
work_624qrp646zf4pdga57ub3qks2i	3	72	deficiency	deficiency	NN
work_624qrp646zf4pdga57ub3qks2i	3	73	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	3	74	,	,	,
work_624qrp646zf4pdga57ub3qks2i	3	75	ultimately	ultimately	RB
work_624qrp646zf4pdga57ub3qks2i	3	76	,	,	,
work_624qrp646zf4pdga57ub3qks2i	3	77	hyperglycemia	hyperglycemia	NN
work_624qrp646zf4pdga57ub3qks2i	3	78	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	3	79	inflicted	inflict	VBN
work_624qrp646zf4pdga57ub3qks2i	3	80	individuals	individual	NNS
work_624qrp646zf4pdga57ub3qks2i	3	81	.	.	.
work_624qrp646zf4pdga57ub3qks2i	4	1	The	the	DT
work_624qrp646zf4pdga57ub3qks2i	4	2	etiology	etiology	NN
work_624qrp646zf4pdga57ub3qks2i	4	3	stems	stem	VBZ
work_624qrp646zf4pdga57ub3qks2i	4	4	from	from	IN
work_624qrp646zf4pdga57ub3qks2i	4	5	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	4	6	progressive	progressive	JJ
work_624qrp646zf4pdga57ub3qks2i	4	7	autoimmune	autoimmune	JJ
work_624qrp646zf4pdga57ub3qks2i	4	8	assault	assault	NN
work_624qrp646zf4pdga57ub3qks2i	4	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	4	10	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	4	11	which	which	WDT
work_624qrp646zf4pdga57ub3qks2i	4	12	macrophages	macrophage	NNS
work_624qrp646zf4pdga57ub3qks2i	4	13	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	4	14	T	T	NNP
work_624qrp646zf4pdga57ub3qks2i	4	15	cells	cell	NNS
work_624qrp646zf4pdga57ub3qks2i	4	16	secrete	secrete	VBP
work_624qrp646zf4pdga57ub3qks2i	4	17	proinflammatory	proinflammatory	JJ
work_624qrp646zf4pdga57ub3qks2i	4	18	cytokines	cytokine	NNS
work_624qrp646zf4pdga57ub3qks2i	4	19	,	,	,
work_624qrp646zf4pdga57ub3qks2i	4	20	such	such	JJ
work_624qrp646zf4pdga57ub3qks2i	4	21	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	4	22	IL-1	IL-1	NNP
work_624qrp646zf4pdga57ub3qks2i	4	23	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	4	24	,	,	,
work_624qrp646zf4pdga57ub3qks2i	4	25	IFN-	IFN-	NNP
work_624qrp646zf4pdga57ub3qks2i	4	26	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	4	27	,	,	,
work_624qrp646zf4pdga57ub3qks2i	4	28	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	4	29	TNF-	TNF-	NNP
work_624qrp646zf4pdga57ub3qks2i	4	30	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	4	31	,	,	,
work_624qrp646zf4pdga57ub3qks2i	4	32	as	as	RB
work_624qrp646zf4pdga57ub3qks2i	4	33	well	well	RB
work_624qrp646zf4pdga57ub3qks2i	4	34	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	4	35	nitric	nitric	JJ
work_624qrp646zf4pdga57ub3qks2i	4	36	oxide	oxide	NN
work_624qrp646zf4pdga57ub3qks2i	4	37	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	4	38	NO	no	UH
work_624qrp646zf4pdga57ub3qks2i	4	39	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	4	40	,	,	,
work_624qrp646zf4pdga57ub3qks2i	4	41	which	which	WDT
work_624qrp646zf4pdga57ub3qks2i	4	42	provoke	provoke	VBD
work_624qrp646zf4pdga57ub3qks2i	4	43	�	�	NN
work_624qrp646zf4pdga57ub3qks2i	4	44	-cell	-cell	JJ
work_624qrp646zf4pdga57ub3qks2i	4	45	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	4	46	.	.	.
work_624qrp646zf4pdga57ub3qks2i	5	1	The	the	DT
work_624qrp646zf4pdga57ub3qks2i	5	2	latter	latter	JJ
work_624qrp646zf4pdga57ub3qks2i	5	3	situation	situation	NN
work_624qrp646zf4pdga57ub3qks2i	5	4	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	5	5	further	further	RB
work_624qrp646zf4pdga57ub3qks2i	5	6	aggravated	aggravate	VBN
work_624qrp646zf4pdga57ub3qks2i	5	7	,	,	,
work_624qrp646zf4pdga57ub3qks2i	5	8	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	5	9	remaining	remain	VBG
work_624qrp646zf4pdga57ub3qks2i	5	10	�	�	NN
work_624qrp646zf4pdga57ub3qks2i	5	11	-cells	-cells	,
work_624qrp646zf4pdga57ub3qks2i	5	12	produce	produce	VBP
work_624qrp646zf4pdga57ub3qks2i	5	13	chemokines	chemokine	NNS
work_624qrp646zf4pdga57ub3qks2i	5	14	,	,	,
work_624qrp646zf4pdga57ub3qks2i	5	15	thereby	thereby	RB
work_624qrp646zf4pdga57ub3qks2i	5	16	attracting	attract	VBG
work_624qrp646zf4pdga57ub3qks2i	5	17	more	more	JJR
work_624qrp646zf4pdga57ub3qks2i	5	18	immune	immune	JJ
work_624qrp646zf4pdga57ub3qks2i	5	19	cells	cell	NNS
work_624qrp646zf4pdga57ub3qks2i	5	20	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	5	21	,	,	,
work_624qrp646zf4pdga57ub3qks2i	5	22	thus	thus	RB
work_624qrp646zf4pdga57ub3qks2i	5	23	,	,	,
work_624qrp646zf4pdga57ub3qks2i	5	24	escalating	escalate	VBG
work_624qrp646zf4pdga57ub3qks2i	5	25	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	5	26	inflammatory	inflammatory	JJ
work_624qrp646zf4pdga57ub3qks2i	5	27	process	process	NN
work_624qrp646zf4pdga57ub3qks2i	5	28	.	.	.
work_624qrp646zf4pdga57ub3qks2i	6	1	Cytokine	Cytokine	NNP
work_624qrp646zf4pdga57ub3qks2i	6	2	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	6	3	me-	me-	NN
work_624qrp646zf4pdga57ub3qks2i	6	4	diated	diated	JJ
work_624qrp646zf4pdga57ub3qks2i	6	5	cell	cell	NN
work_624qrp646zf4pdga57ub3qks2i	6	6	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	6	7	proceeds	proceed	NNS
work_624qrp646zf4pdga57ub3qks2i	6	8	through	through	IN
work_624qrp646zf4pdga57ub3qks2i	6	9	necrosis	necrosis	NN
work_624qrp646zf4pdga57ub3qks2i	6	10	or	or	CC
work_624qrp646zf4pdga57ub3qks2i	6	11	apoptosis	apoptosis	NN
work_624qrp646zf4pdga57ub3qks2i	6	12	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	6	13	implicates	implicate	VBZ
work_624qrp646zf4pdga57ub3qks2i	6	14	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	6	15	activation	activation	NN
work_624qrp646zf4pdga57ub3qks2i	6	16	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	6	17	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	6	18	Jak	Jak	NNP
work_624qrp646zf4pdga57ub3qks2i	6	19	/	/	SYM
work_624qrp646zf4pdga57ub3qks2i	6	20	Stat	Stat	NNP
work_624qrp646zf4pdga57ub3qks2i	6	21	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	6	22	NF-	NF-	NNP
work_624qrp646zf4pdga57ub3qks2i	6	23	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	6	24	B	b	NN
work_624qrp646zf4pdga57ub3qks2i	6	25	signaling	signal	VBG
work_624qrp646zf4pdga57ub3qks2i	6	26	pathways	pathway	NNS
work_624qrp646zf4pdga57ub3qks2i	6	27	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	6	28	4	4	CD
work_624qrp646zf4pdga57ub3qks2i	6	29	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	6	30	.	.	.
work_624qrp646zf4pdga57ub3qks2i	7	1	A	a	DT
work_624qrp646zf4pdga57ub3qks2i	7	2	common	common	JJ
work_624qrp646zf4pdga57ub3qks2i	7	3	downstream	downstream	JJ
work_624qrp646zf4pdga57ub3qks2i	7	4	target	target	NN
work_624qrp646zf4pdga57ub3qks2i	7	5	gene	gene	NN
work_624qrp646zf4pdga57ub3qks2i	7	6	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	7	7	these	these	DT
work_624qrp646zf4pdga57ub3qks2i	7	8	pathways	pathway	NNS
work_624qrp646zf4pdga57ub3qks2i	7	9	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	7	10	inducible	inducible	JJ
work_624qrp646zf4pdga57ub3qks2i	7	11	NO	no	DT
work_624qrp646zf4pdga57ub3qks2i	7	12	synthase	synthase	NN
work_624qrp646zf4pdga57ub3qks2i	7	13	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	7	14	iNOS	inos	NN
work_624qrp646zf4pdga57ub3qks2i	7	15	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	7	16	,	,	,
work_624qrp646zf4pdga57ub3qks2i	7	17	which	which	WDT
work_624qrp646zf4pdga57ub3qks2i	7	18	generates	generate	VBZ
work_624qrp646zf4pdga57ub3qks2i	7	19	NO	NO	NNP
work_624qrp646zf4pdga57ub3qks2i	7	20	,	,	,
work_624qrp646zf4pdga57ub3qks2i	7	21	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	7	22	major	major	JJ
work_624qrp646zf4pdga57ub3qks2i	7	23	effector	effector	NN
work_624qrp646zf4pdga57ub3qks2i	7	24	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	7	25	�	�	JJ
work_624qrp646zf4pdga57ub3qks2i	7	26	-cell	-cell	JJ
work_624qrp646zf4pdga57ub3qks2i	7	27	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	7	28	along	along	IN
work_624qrp646zf4pdga57ub3qks2i	7	29	with	with	IN
work_624qrp646zf4pdga57ub3qks2i	7	30	reactive	reactive	JJ
work_624qrp646zf4pdga57ub3qks2i	7	31	oxygen	oxygen	NN
work_624qrp646zf4pdga57ub3qks2i	7	32	species	specie	NNS
work_624qrp646zf4pdga57ub3qks2i	7	33	.	.	.
work_624qrp646zf4pdga57ub3qks2i	8	1	Historically	historically	RB
work_624qrp646zf4pdga57ub3qks2i	8	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	8	3	T1DM	T1DM	NNP
work_624qrp646zf4pdga57ub3qks2i	8	4	has	have	VBZ
work_624qrp646zf4pdga57ub3qks2i	8	5	been	be	VBN
work_624qrp646zf4pdga57ub3qks2i	8	6	recapitulated	recapitulate	VBN
work_624qrp646zf4pdga57ub3qks2i	8	7	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	8	8	rodents	rodent	NNS
work_624qrp646zf4pdga57ub3qks2i	8	9	with	with	IN
work_624qrp646zf4pdga57ub3qks2i	8	10	use	use	NN
work_624qrp646zf4pdga57ub3qks2i	8	11	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	8	12	diabetogenic	diabetogenic	JJ
work_624qrp646zf4pdga57ub3qks2i	8	13	agents	agent	NNS
work_624qrp646zf4pdga57ub3qks2i	8	14	,	,	,
work_624qrp646zf4pdga57ub3qks2i	8	15	such	such	JJ
work_624qrp646zf4pdga57ub3qks2i	8	16	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	8	17	streptozotocin	streptozotocin	NN
work_624qrp646zf4pdga57ub3qks2i	8	18	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	8	19	STZ	STZ	NNP
work_624qrp646zf4pdga57ub3qks2i	8	20	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	8	21	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	8	22	alloxan	alloxan	VBD
work_624qrp646zf4pdga57ub3qks2i	8	23	,	,	,
work_624qrp646zf4pdga57ub3qks2i	8	24	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	8	25	destroy	destroy	VB
work_624qrp646zf4pdga57ub3qks2i	8	26	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	8	27	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	8	28	-cell	-cell	NNP
work_624qrp646zf4pdga57ub3qks2i	8	29	mass	mass	NNP
work_624qrp646zf4pdga57ub3qks2i	8	30	.	.	.
work_624qrp646zf4pdga57ub3qks2i	9	1	In	in	IN
work_624qrp646zf4pdga57ub3qks2i	9	2	particular	particular	JJ
work_624qrp646zf4pdga57ub3qks2i	9	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	9	4	STZ	stz	NN
work_624qrp646zf4pdga57ub3qks2i	9	5	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	9	6	distinctly	distinctly	RB
work_624qrp646zf4pdga57ub3qks2i	9	7	taken	take	VBN
work_624qrp646zf4pdga57ub3qks2i	9	8	up	up	RP
work_624qrp646zf4pdga57ub3qks2i	9	9	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	9	10	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	9	11	-cells	-cells	,
work_624qrp646zf4pdga57ub3qks2i	9	12	,	,	,
work_624qrp646zf4pdga57ub3qks2i	9	13	inducing	induce	VBG
work_624qrp646zf4pdga57ub3qks2i	9	14	DNA	dna	NN
work_624qrp646zf4pdga57ub3qks2i	9	15	alkylation	alkylation	NN
work_624qrp646zf4pdga57ub3qks2i	9	16	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	9	17	leading	lead	VBG
work_624qrp646zf4pdga57ub3qks2i	9	18	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	9	19	impaired	impaired	JJ
work_624qrp646zf4pdga57ub3qks2i	9	20	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	9	21	-cell	-cell	CD
work_624qrp646zf4pdga57ub3qks2i	9	22	function	function	NN
work_624qrp646zf4pdga57ub3qks2i	9	23	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	9	24	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	9	25	.	.	.
work_624qrp646zf4pdga57ub3qks2i	10	1	In	in	IN
work_624qrp646zf4pdga57ub3qks2i	10	2	addition	addition	NN
work_624qrp646zf4pdga57ub3qks2i	10	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	10	4	STZ	STZ	NNP
work_624qrp646zf4pdga57ub3qks2i	10	5	was	be	VBD
work_624qrp646zf4pdga57ub3qks2i	10	6	also	also	RB
work_624qrp646zf4pdga57ub3qks2i	10	7	found	find	VBN
work_624qrp646zf4pdga57ub3qks2i	10	8	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	10	9	generate	generate	VB
work_624qrp646zf4pdga57ub3qks2i	10	10	NO	no	DT
work_624qrp646zf4pdga57ub3qks2i	10	11	species	specie	NNS
work_624qrp646zf4pdga57ub3qks2i	10	12	,	,	,
work_624qrp646zf4pdga57ub3qks2i	10	13	further	further	RB
work_624qrp646zf4pdga57ub3qks2i	10	14	deteriorating	deteriorate	VBG
work_624qrp646zf4pdga57ub3qks2i	10	15	�	�	JJ
work_624qrp646zf4pdga57ub3qks2i	10	16	-cell	-cell	JJ
work_624qrp646zf4pdga57ub3qks2i	10	17	survival	survival	NN
work_624qrp646zf4pdga57ub3qks2i	10	18	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	10	19	7	7	CD
work_624qrp646zf4pdga57ub3qks2i	10	20	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	10	21	.	.	.
work_624qrp646zf4pdga57ub3qks2i	11	1	More	More	JJR
work_624qrp646zf4pdga57ub3qks2i	11	2	than	than	IN
work_624qrp646zf4pdga57ub3qks2i	11	3	30	30	CD
work_624qrp646zf4pdga57ub3qks2i	11	4	years	year	NNS
work_624qrp646zf4pdga57ub3qks2i	11	5	ago	ago	RB
work_624qrp646zf4pdga57ub3qks2i	11	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	11	7	Okamoto	Okamoto	NNP
work_624qrp646zf4pdga57ub3qks2i	11	8	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	11	9	colleagues	colleague	NNS
work_624qrp646zf4pdga57ub3qks2i	11	10	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	11	11	13	13	CD
work_624qrp646zf4pdga57ub3qks2i	11	12	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	11	13	demonstrated	demonstrate	VBD
work_624qrp646zf4pdga57ub3qks2i	11	14	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	11	15	STZ	stz	NN
work_624qrp646zf4pdga57ub3qks2i	11	16	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	11	17	alloxan	alloxan	VBN
work_624qrp646zf4pdga57ub3qks2i	11	18	cause	cause	NN
work_624qrp646zf4pdga57ub3qks2i	11	19	cell	cell	NN
work_624qrp646zf4pdga57ub3qks2i	11	20	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	11	21	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	11	22	inducing	induce	VBG
work_624qrp646zf4pdga57ub3qks2i	11	23	DNA	dna	NN
work_624qrp646zf4pdga57ub3qks2i	11	24	strand	strand	NN
work_624qrp646zf4pdga57ub3qks2i	11	25	breaks	break	NNS
work_624qrp646zf4pdga57ub3qks2i	11	26	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	11	27	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	11	28	activation	activation	NN
work_624qrp646zf4pdga57ub3qks2i	11	29	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	11	30	poly(ADP)-ribose	poly(ADP)-ribose	NNP
work_624qrp646zf4pdga57ub3qks2i	11	31	synthase	synthase	NN
work_624qrp646zf4pdga57ub3qks2i	11	32	.	.	.
work_624qrp646zf4pdga57ub3qks2i	12	1	This	this	DT
work_624qrp646zf4pdga57ub3qks2i	12	2	enzyme	enzyme	NNS
work_624qrp646zf4pdga57ub3qks2i	12	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	12	4	also	also	RB
work_624qrp646zf4pdga57ub3qks2i	12	5	known	know	VBN
work_624qrp646zf4pdga57ub3qks2i	12	6	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	12	7	poly-	poly-	NNS
work_624qrp646zf4pdga57ub3qks2i	12	8	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	12	9	ADP)-ribose	ADP)-ribose	``
work_624qrp646zf4pdga57ub3qks2i	12	10	polymerase-1	polymerase-1	NNP
work_624qrp646zf4pdga57ub3qks2i	12	11	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	12	12	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	12	13	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	12	14	,	,	,
work_624qrp646zf4pdga57ub3qks2i	12	15	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	12	16	activated	activate	VBN
work_624qrp646zf4pdga57ub3qks2i	12	17	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	12	18	DNA	dna	NN
work_624qrp646zf4pdga57ub3qks2i	12	19	breaks	break	NNS
work_624qrp646zf4pdga57ub3qks2i	12	20	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	12	21	uses	use	VBZ
work_624qrp646zf4pdga57ub3qks2i	12	22	NAD	NAD	NNP
work_624qrp646zf4pdga57ub3qks2i	12	23	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	12	24	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	12	25	covalently	covalently	RB
work_624qrp646zf4pdga57ub3qks2i	12	26	link	link	VB
work_624qrp646zf4pdga57ub3qks2i	12	27	units	unit	NNS
work_624qrp646zf4pdga57ub3qks2i	12	28	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	12	29	ADP	ADP	NNP
work_624qrp646zf4pdga57ub3qks2i	12	30	ribose	ribose	NN
work_624qrp646zf4pdga57ub3qks2i	12	31	,	,	,
work_624qrp646zf4pdga57ub3qks2i	12	32	thereby	thereby	RB
work_624qrp646zf4pdga57ub3qks2i	12	33	forming	form	VBG
work_624qrp646zf4pdga57ub3qks2i	12	34	long	long	JJ
work_624qrp646zf4pdga57ub3qks2i	12	35	polymers	polymer	NNS
work_624qrp646zf4pdga57ub3qks2i	12	36	on	on	IN
work_624qrp646zf4pdga57ub3qks2i	12	37	nuclear	nuclear	JJ
work_624qrp646zf4pdga57ub3qks2i	12	38	acceptor	acceptor	NN
work_624qrp646zf4pdga57ub3qks2i	12	39	proteins	protein	NNS
work_624qrp646zf4pdga57ub3qks2i	12	40	such	such	JJ
work_624qrp646zf4pdga57ub3qks2i	12	41	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	12	42	histones	histone	NNS
work_624qrp646zf4pdga57ub3qks2i	12	43	.	.	.
work_624qrp646zf4pdga57ub3qks2i	13	1	This	this	DT
work_624qrp646zf4pdga57ub3qks2i	13	2	has	have	VBZ
work_624qrp646zf4pdga57ub3qks2i	13	3	been	be	VBN
work_624qrp646zf4pdga57ub3qks2i	13	4	suggested	suggest	VBN
work_624qrp646zf4pdga57ub3qks2i	13	5	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	13	6	diminish	diminish	VB
work_624qrp646zf4pdga57ub3qks2i	13	7	their	-PRON-	PRP$
work_624qrp646zf4pdga57ub3qks2i	13	8	affinity	affinity	NN
work_624qrp646zf4pdga57ub3qks2i	13	9	for	for	IN
work_624qrp646zf4pdga57ub3qks2i	13	10	DNA	dna	NN
work_624qrp646zf4pdga57ub3qks2i	13	11	,	,	,
work_624qrp646zf4pdga57ub3qks2i	13	12	opening	open	VBG
work_624qrp646zf4pdga57ub3qks2i	13	13	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	13	14	site	site	NN
work_624qrp646zf4pdga57ub3qks2i	13	15	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	13	16	DNA	dna	NN
work_624qrp646zf4pdga57ub3qks2i	13	17	damage	damage	NN
work_624qrp646zf4pdga57ub3qks2i	13	18	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	13	19	allowing	allow	VBG
work_624qrp646zf4pdga57ub3qks2i	13	20	access	access	NN
work_624qrp646zf4pdga57ub3qks2i	13	21	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	13	22	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	13	23	base	base	NN
work_624qrp646zf4pdga57ub3qks2i	13	24	excision	excision	NN
work_624qrp646zf4pdga57ub3qks2i	13	25	repair	repair	NN
work_624qrp646zf4pdga57ub3qks2i	13	26	machinery	machinery	NN
work_624qrp646zf4pdga57ub3qks2i	13	27	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	13	28	8)	8)	CD
work_624qrp646zf4pdga57ub3qks2i	13	29	.	.	.
work_624qrp646zf4pdga57ub3qks2i	14	1	Despite	despite	IN
work_624qrp646zf4pdga57ub3qks2i	14	2	this	this	DT
work_624qrp646zf4pdga57ub3qks2i	14	3	important	important	JJ
work_624qrp646zf4pdga57ub3qks2i	14	4	role	role	NN
work_624qrp646zf4pdga57ub3qks2i	14	5	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	14	6	signaling	signal	VBG
work_624qrp646zf4pdga57ub3qks2i	14	7	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	14	8	facilitating	facilitate	VBG
work_624qrp646zf4pdga57ub3qks2i	14	9	DNA	dna	NN
work_624qrp646zf4pdga57ub3qks2i	14	10	repair	repair	NN
work_624qrp646zf4pdga57ub3qks2i	14	11	,	,	,
work_624qrp646zf4pdga57ub3qks2i	14	12	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	14	13	split	split	JJ
work_624qrp646zf4pdga57ub3qks2i	14	14	functional	functional	JJ
work_624qrp646zf4pdga57ub3qks2i	14	15	personality	personality	NN
work_624qrp646zf4pdga57ub3qks2i	14	16	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	14	17	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	14	18	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	14	19	Mr.	Mr.	NNP
work_624qrp646zf4pdga57ub3qks2i	14	20	Hyde	Hyde	NNP
work_624qrp646zf4pdga57ub3qks2i	14	21	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	14	22	Dr.	Dr.	NNP
work_624qrp646zf4pdga57ub3qks2i	14	23	Jeckyll	Jeckyll	NNP
work_624qrp646zf4pdga57ub3qks2i	14	24	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	14	25	revealed	reveal	VBN
work_624qrp646zf4pdga57ub3qks2i	14	26	when	when	WRB
work_624qrp646zf4pdga57ub3qks2i	14	27	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	14	28	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	14	29	hyperactivated	hyperactivate	VBN
work_624qrp646zf4pdga57ub3qks2i	14	30	.	.	.
work_624qrp646zf4pdga57ub3qks2i	15	1	Indeed	indeed	RB
work_624qrp646zf4pdga57ub3qks2i	15	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	15	3	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	15	4	an	an	DT
work_624qrp646zf4pdga57ub3qks2i	15	5	attempt	attempt	NN
work_624qrp646zf4pdga57ub3qks2i	15	6	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	15	7	replenish	replenish	VB
work_624qrp646zf4pdga57ub3qks2i	15	8	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	15	9	NAD	NAD	NNP
work_624qrp646zf4pdga57ub3qks2i	15	10	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	15	11	pool	pool	NN
work_624qrp646zf4pdga57ub3qks2i	15	12	that	that	WDT
work_624qrp646zf4pdga57ub3qks2i	15	13	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	15	14	being	be	VBG
work_624qrp646zf4pdga57ub3qks2i	15	15	drained	drain	VBN
work_624qrp646zf4pdga57ub3qks2i	15	16	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	15	17	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	15	18	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	15	19	,	,	,
work_624qrp646zf4pdga57ub3qks2i	15	20	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	15	21	cellular	cellular	JJ
work_624qrp646zf4pdga57ub3qks2i	15	22	ATP	ATP	NNP
work_624qrp646zf4pdga57ub3qks2i	15	23	stores	store	NNS
work_624qrp646zf4pdga57ub3qks2i	15	24	are	be	VBP
work_624qrp646zf4pdga57ub3qks2i	15	25	rapidly	rapidly	RB
work_624qrp646zf4pdga57ub3qks2i	15	26	exhausted	exhaust	VBN
work_624qrp646zf4pdga57ub3qks2i	15	27	,	,	,
work_624qrp646zf4pdga57ub3qks2i	15	28	resulting	result	VBG
work_624qrp646zf4pdga57ub3qks2i	15	29	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	15	30	energy	energy	NN
work_624qrp646zf4pdga57ub3qks2i	15	31	crisis	crisis	NN
work_624qrp646zf4pdga57ub3qks2i	15	32	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	15	33	induced	induce	VBN
work_624qrp646zf4pdga57ub3qks2i	15	34	necrosis	necrosis	NN
work_624qrp646zf4pdga57ub3qks2i	15	35	.	.	.
work_624qrp646zf4pdga57ub3qks2i	16	1	The	the	DT
work_624qrp646zf4pdga57ub3qks2i	16	2	latter	latter	JJ
work_624qrp646zf4pdga57ub3qks2i	16	3	forms	form	VBZ
work_624qrp646zf4pdga57ub3qks2i	16	4	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	16	5	basis	basis	NN
work_624qrp646zf4pdga57ub3qks2i	16	6	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	16	7	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	16	8	“	"	``
work_624qrp646zf4pdga57ub3qks2i	16	9	Okamoto	Okamoto	NNP
work_624qrp646zf4pdga57ub3qks2i	16	10	model	model	NN
work_624qrp646zf4pdga57ub3qks2i	16	11	,	,	,
work_624qrp646zf4pdga57ub3qks2i	16	12	”	"	''
work_624qrp646zf4pdga57ub3qks2i	16	13	which	which	WDT
work_624qrp646zf4pdga57ub3qks2i	16	14	provides	provide	VBZ
work_624qrp646zf4pdga57ub3qks2i	16	15	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	16	16	unifying	unifying	JJ
work_624qrp646zf4pdga57ub3qks2i	16	17	hypothesis	hypothesis	NN
work_624qrp646zf4pdga57ub3qks2i	16	18	on	on	IN
work_624qrp646zf4pdga57ub3qks2i	16	19	how	how	WRB
work_624qrp646zf4pdga57ub3qks2i	16	20	hyperactivation	hyperactivation	NN
work_624qrp646zf4pdga57ub3qks2i	16	21	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	16	22	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	16	23	leads	lead	VBZ
work_624qrp646zf4pdga57ub3qks2i	16	24	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	16	25	impaired	impair	VBN
work_624qrp646zf4pdga57ub3qks2i	16	26	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	16	27	-cell	-cell	CD
work_624qrp646zf4pdga57ub3qks2i	16	28	function	function	NN
work_624qrp646zf4pdga57ub3qks2i	16	29	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	16	30	insulin	insulin	NN
work_624qrp646zf4pdga57ub3qks2i	16	31	biosynthesis	biosynthesis	NN
work_624qrp646zf4pdga57ub3qks2i	16	32	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	16	33	secretion	secretion	NN
work_624qrp646zf4pdga57ub3qks2i	16	34	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	16	35	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	16	36	,	,	,
work_624qrp646zf4pdga57ub3qks2i	16	37	ultimately	ultimately	RB
work_624qrp646zf4pdga57ub3qks2i	16	38	,	,	,
work_624qrp646zf4pdga57ub3qks2i	16	39	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	16	40	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	16	41	response	response	NN
work_624qrp646zf4pdga57ub3qks2i	16	42	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	16	43	chemical	chemical	JJ
work_624qrp646zf4pdga57ub3qks2i	16	44	insults	insult	NNS
work_624qrp646zf4pdga57ub3qks2i	16	45	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	16	46	12	12	CD
work_624qrp646zf4pdga57ub3qks2i	16	47	,	,	,
work_624qrp646zf4pdga57ub3qks2i	16	48	13	13	CD
work_624qrp646zf4pdga57ub3qks2i	16	49	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	16	50	.	.	.
work_624qrp646zf4pdga57ub3qks2i	17	1	In	in	IN
work_624qrp646zf4pdga57ub3qks2i	17	2	agreement	agreement	NN
work_624qrp646zf4pdga57ub3qks2i	17	3	with	with	IN
work_624qrp646zf4pdga57ub3qks2i	17	4	this	this	DT
work_624qrp646zf4pdga57ub3qks2i	17	5	model	model	NN
work_624qrp646zf4pdga57ub3qks2i	17	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	17	7	several	several	JJ
work_624qrp646zf4pdga57ub3qks2i	17	8	independent	independent	JJ
work_624qrp646zf4pdga57ub3qks2i	17	9	studies	study	NNS
work_624qrp646zf4pdga57ub3qks2i	17	10	have	have	VBP
work_624qrp646zf4pdga57ub3qks2i	17	11	shown	show	VBN
work_624qrp646zf4pdga57ub3qks2i	17	12	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	17	13	mice	mouse	NNS
work_624qrp646zf4pdga57ub3qks2i	17	14	lacking	lack	VBG
work_624qrp646zf4pdga57ub3qks2i	17	15	PARP-1	PARP-1	NNS
work_624qrp646zf4pdga57ub3qks2i	17	16	were	be	VBD
work_624qrp646zf4pdga57ub3qks2i	17	17	resistant	resistant	JJ
work_624qrp646zf4pdga57ub3qks2i	17	18	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	17	19	STZ-	STZ-	NNP
work_624qrp646zf4pdga57ub3qks2i	17	20	mediated	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	17	21	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	17	22	-cell	-cell	JJ
work_624qrp646zf4pdga57ub3qks2i	17	23	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	17	24	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	17	25	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	17	26	development	development	NN
work_624qrp646zf4pdga57ub3qks2i	17	27	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	17	28	hyperglycemia	hyperglycemia	NN
work_624qrp646zf4pdga57ub3qks2i	17	29	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	17	30	3	3	CD
work_624qrp646zf4pdga57ub3qks2i	17	31	,	,	,
work_624qrp646zf4pdga57ub3qks2i	17	32	9	9	CD
work_624qrp646zf4pdga57ub3qks2i	17	33	,	,	,
work_624qrp646zf4pdga57ub3qks2i	17	34	11	11	CD
work_624qrp646zf4pdga57ub3qks2i	17	35	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	17	36	.	.	.
work_624qrp646zf4pdga57ub3qks2i	18	1	In	in	IN
work_624qrp646zf4pdga57ub3qks2i	18	2	parallel	parallel	NN
work_624qrp646zf4pdga57ub3qks2i	18	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	18	4	PARP-1-deficient	parp-1-deficient	JJ
work_624qrp646zf4pdga57ub3qks2i	18	5	mice	mouse	NNS
work_624qrp646zf4pdga57ub3qks2i	18	6	were	be	VBD
work_624qrp646zf4pdga57ub3qks2i	18	7	found	find	VBN
work_624qrp646zf4pdga57ub3qks2i	18	8	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	18	9	be	be	VB
work_624qrp646zf4pdga57ub3qks2i	18	10	extremely	extremely	RB
work_624qrp646zf4pdga57ub3qks2i	18	11	resistant	resistant	JJ
work_624qrp646zf4pdga57ub3qks2i	18	12	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	18	13	LPS	LPS	NNP
work_624qrp646zf4pdga57ub3qks2i	18	14	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	18	15	induced	induce	VBN
work_624qrp646zf4pdga57ub3qks2i	18	16	endotoxic	endotoxic	JJ
work_624qrp646zf4pdga57ub3qks2i	18	17	shock	shock	NN
work_624qrp646zf4pdga57ub3qks2i	18	18	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	18	19	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	18	20	con-	con-	NN
work_624qrp646zf4pdga57ub3qks2i	18	21	sequence	sequence	NN
work_624qrp646zf4pdga57ub3qks2i	18	22	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	18	23	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	18	24	blunted	blunt	VBN
work_624qrp646zf4pdga57ub3qks2i	18	25	NF-	NF-	NNP
work_624qrp646zf4pdga57ub3qks2i	18	26	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	18	27	B	b	NN
work_624qrp646zf4pdga57ub3qks2i	18	28	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	18	29	dependent	dependent	JJ
work_624qrp646zf4pdga57ub3qks2i	18	30	transcription	transcription	NN
work_624qrp646zf4pdga57ub3qks2i	18	31	,	,	,
work_624qrp646zf4pdga57ub3qks2i	18	32	leading	lead	VBG
work_624qrp646zf4pdga57ub3qks2i	18	33	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	18	34	inhibition	inhibition	NN
work_624qrp646zf4pdga57ub3qks2i	18	35	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	18	36	iNOS	inos	NN
work_624qrp646zf4pdga57ub3qks2i	18	37	,	,	,
work_624qrp646zf4pdga57ub3qks2i	18	38	as	as	RB
work_624qrp646zf4pdga57ub3qks2i	18	39	well	well	RB
work_624qrp646zf4pdga57ub3qks2i	18	40	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	18	41	TNF-	TNF-	NNP
work_624qrp646zf4pdga57ub3qks2i	18	42	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	18	43	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	18	44	IFN-	IFN-	NNP
work_624qrp646zf4pdga57ub3qks2i	18	45	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	18	46	,	,	,
work_624qrp646zf4pdga57ub3qks2i	18	47	expression	expression	NN
work_624qrp646zf4pdga57ub3qks2i	18	48	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	18	49	macrophages	macrophage	NNS
work_624qrp646zf4pdga57ub3qks2i	18	50	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	18	51	10	10	CD
work_624qrp646zf4pdga57ub3qks2i	18	52	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	18	53	.	.	.
work_624qrp646zf4pdga57ub3qks2i	19	1	Thus	thus	RB
work_624qrp646zf4pdga57ub3qks2i	19	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	19	3	PARP-1	PARP-1	NNS
work_624qrp646zf4pdga57ub3qks2i	19	4	not	not	RB
work_624qrp646zf4pdga57ub3qks2i	19	5	only	only	RB
work_624qrp646zf4pdga57ub3qks2i	19	6	mediates	mediate	VBZ
work_624qrp646zf4pdga57ub3qks2i	19	7	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	19	8	cytotoxic	cytotoxic	JJ
work_624qrp646zf4pdga57ub3qks2i	19	9	effect	effect	NN
work_624qrp646zf4pdga57ub3qks2i	19	10	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	19	11	NO	no	UH
work_624qrp646zf4pdga57ub3qks2i	19	12	,	,	,
work_624qrp646zf4pdga57ub3qks2i	19	13	but	but	CC
work_624qrp646zf4pdga57ub3qks2i	19	14	it	-PRON-	PRP
work_624qrp646zf4pdga57ub3qks2i	19	15	also	also	RB
work_624qrp646zf4pdga57ub3qks2i	19	16	appears	appear	VBZ
work_624qrp646zf4pdga57ub3qks2i	19	17	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	19	18	stimulate	stimulate	VB
work_624qrp646zf4pdga57ub3qks2i	19	19	inflam-	inflam-	NN
work_624qrp646zf4pdga57ub3qks2i	19	20	mation	mation	NN
work_624qrp646zf4pdga57ub3qks2i	19	21	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	19	22	regulating	regulate	VBG
work_624qrp646zf4pdga57ub3qks2i	19	23	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	19	24	NF-	NF-	NNP
work_624qrp646zf4pdga57ub3qks2i	19	25	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	19	26	B	B	NNP
work_624qrp646zf4pdga57ub3qks2i	19	27	signal	signal	NN
work_624qrp646zf4pdga57ub3qks2i	19	28	transduction	transduction	NN
work_624qrp646zf4pdga57ub3qks2i	19	29	pathway	pathway	NN
work_624qrp646zf4pdga57ub3qks2i	19	30	.	.	.
work_624qrp646zf4pdga57ub3qks2i	20	1	These	these	DT
work_624qrp646zf4pdga57ub3qks2i	20	2	compelling	compelling	JJ
work_624qrp646zf4pdga57ub3qks2i	20	3	data	datum	NNS
work_624qrp646zf4pdga57ub3qks2i	20	4	led	lead	VBD
work_624qrp646zf4pdga57ub3qks2i	20	5	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	20	6	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	20	7	large	large	JJ
work_624qrp646zf4pdga57ub3qks2i	20	8	randomized	randomized	JJ
work_624qrp646zf4pdga57ub3qks2i	20	9	double-	double-	NNS
work_624qrp646zf4pdga57ub3qks2i	20	10	blind	blind	JJ
work_624qrp646zf4pdga57ub3qks2i	20	11	,	,	,
work_624qrp646zf4pdga57ub3qks2i	20	12	placebo	placebo	NN
work_624qrp646zf4pdga57ub3qks2i	20	13	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	20	14	controlled	control	VBN
work_624qrp646zf4pdga57ub3qks2i	20	15	trial	trial	NN
work_624qrp646zf4pdga57ub3qks2i	20	16	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	20	17	which	which	WDT
work_624qrp646zf4pdga57ub3qks2i	20	18	pre	pre	JJ
work_624qrp646zf4pdga57ub3qks2i	20	19	-	-	JJ
work_624qrp646zf4pdga57ub3qks2i	20	20	T1DM	t1dm	JJ
work_624qrp646zf4pdga57ub3qks2i	20	21	participants	participant	NNS
work_624qrp646zf4pdga57ub3qks2i	20	22	recruited	recruit	VBN
work_624qrp646zf4pdga57ub3qks2i	20	23	from	from	IN
work_624qrp646zf4pdga57ub3qks2i	20	24	18	18	CD
work_624qrp646zf4pdga57ub3qks2i	20	25	European	european	JJ
work_624qrp646zf4pdga57ub3qks2i	20	26	countries	country	NNS
work_624qrp646zf4pdga57ub3qks2i	20	27	,	,	,
work_624qrp646zf4pdga57ub3qks2i	20	28	as	as	RB
work_624qrp646zf4pdga57ub3qks2i	20	29	well	well	RB
work_624qrp646zf4pdga57ub3qks2i	20	30	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	20	31	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	20	32	United	United	NNP
work_624qrp646zf4pdga57ub3qks2i	20	33	States	States	NNP
work_624qrp646zf4pdga57ub3qks2i	20	34	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	20	35	Canada	Canada	NNP
work_624qrp646zf4pdga57ub3qks2i	20	36	,	,	,
work_624qrp646zf4pdga57ub3qks2i	20	37	were	be	VBD
work_624qrp646zf4pdga57ub3qks2i	20	38	given	give	VBN
work_624qrp646zf4pdga57ub3qks2i	20	39	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	20	40	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	20	41	inhibitor	inhibitor	NN
work_624qrp646zf4pdga57ub3qks2i	20	42	nicotin-	nicotin-	NN
work_624qrp646zf4pdga57ub3qks2i	20	43	amide	amide	NNP
work_624qrp646zf4pdga57ub3qks2i	20	44	or	or	CC
work_624qrp646zf4pdga57ub3qks2i	20	45	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	20	46	placebo	placebo	NN
work_624qrp646zf4pdga57ub3qks2i	20	47	.	.	.
work_624qrp646zf4pdga57ub3qks2i	21	1	After	after	IN
work_624qrp646zf4pdga57ub3qks2i	21	2	five	five	CD
work_624qrp646zf4pdga57ub3qks2i	21	3	years	year	NNS
work_624qrp646zf4pdga57ub3qks2i	21	4	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	21	5	treatment	treatment	NN
work_624qrp646zf4pdga57ub3qks2i	21	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	21	7	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	21	8	incidence	incidence	NN
work_624qrp646zf4pdga57ub3qks2i	21	9	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	21	10	developing	develop	VBG
work_624qrp646zf4pdga57ub3qks2i	21	11	T1DM	T1DM	NNP
work_624qrp646zf4pdga57ub3qks2i	21	12	was	be	VBD
work_624qrp646zf4pdga57ub3qks2i	21	13	identical	identical	JJ
work_624qrp646zf4pdga57ub3qks2i	21	14	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	21	15	both	both	DT
work_624qrp646zf4pdga57ub3qks2i	21	16	groups	group	NNS
work_624qrp646zf4pdga57ub3qks2i	21	17	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	21	18	5	5	CD
work_624qrp646zf4pdga57ub3qks2i	21	19	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	21	20	.	.	.
work_624qrp646zf4pdga57ub3qks2i	22	1	These	these	DT
work_624qrp646zf4pdga57ub3qks2i	22	2	studies	study	NNS
work_624qrp646zf4pdga57ub3qks2i	22	3	highlight	highlight	VBP
work_624qrp646zf4pdga57ub3qks2i	22	4	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	22	5	complexity	complexity	NN
work_624qrp646zf4pdga57ub3qks2i	22	6	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	22	7	T1DM	T1DM	NNP
work_624qrp646zf4pdga57ub3qks2i	22	8	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	22	9	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	22	10	pitfalls	pitfall	NNS
work_624qrp646zf4pdga57ub3qks2i	22	11	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	22	12	translating	translate	VBG
work_624qrp646zf4pdga57ub3qks2i	22	13	lessons	lesson	NNS
work_624qrp646zf4pdga57ub3qks2i	22	14	learned	learn	VBN
work_624qrp646zf4pdga57ub3qks2i	22	15	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	22	16	animal	animal	NN
work_624qrp646zf4pdga57ub3qks2i	22	17	models	model	NNS
work_624qrp646zf4pdga57ub3qks2i	22	18	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	22	19	diabetes	diabete	NNS
work_624qrp646zf4pdga57ub3qks2i	22	20	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	22	21	human	human	JJ
work_624qrp646zf4pdga57ub3qks2i	22	22	physiology	physiology	NN
work_624qrp646zf4pdga57ub3qks2i	22	23	.	.	.
work_624qrp646zf4pdga57ub3qks2i	23	1	Indeed	indeed	RB
work_624qrp646zf4pdga57ub3qks2i	23	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	23	3	one	one	CD
work_624qrp646zf4pdga57ub3qks2i	23	4	critical	critical	JJ
work_624qrp646zf4pdga57ub3qks2i	23	5	question	question	NN
work_624qrp646zf4pdga57ub3qks2i	23	6	arises	arise	VBZ
work_624qrp646zf4pdga57ub3qks2i	23	7	:	:	:
work_624qrp646zf4pdga57ub3qks2i	23	8	How	how	WRB
work_624qrp646zf4pdga57ub3qks2i	23	9	well	well	RB
work_624qrp646zf4pdga57ub3qks2i	23	10	does	do	VBZ
work_624qrp646zf4pdga57ub3qks2i	23	11	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	23	12	STZ	stz	NN
work_624qrp646zf4pdga57ub3qks2i	23	13	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	23	14	induced	induce	VBN
work_624qrp646zf4pdga57ub3qks2i	23	15	�	�	JJ
work_624qrp646zf4pdga57ub3qks2i	23	16	-cell	-cell	JJ
work_624qrp646zf4pdga57ub3qks2i	23	17	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	23	18	model	model	NN
work_624qrp646zf4pdga57ub3qks2i	23	19	mimic	mimic	NN
work_624qrp646zf4pdga57ub3qks2i	23	20	T1DM	T1DM	NNS
work_624qrp646zf4pdga57ub3qks2i	23	21	?	?	.
work_624qrp646zf4pdga57ub3qks2i	24	1	In	in	IN
work_624qrp646zf4pdga57ub3qks2i	24	2	fact	fact	NN
work_624qrp646zf4pdga57ub3qks2i	24	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	24	4	hyperactivation	hyperactivation	NN
work_624qrp646zf4pdga57ub3qks2i	24	5	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	24	6	PARP-1	parp-1	NN
work_624qrp646zf4pdga57ub3qks2i	24	7	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	24	8	STZ	stz	NN
work_624qrp646zf4pdga57ub3qks2i	24	9	results	result	NNS
work_624qrp646zf4pdga57ub3qks2i	24	10	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	24	11	�	�	JJ
work_624qrp646zf4pdga57ub3qks2i	24	12	-cell	-cell	JJ
work_624qrp646zf4pdga57ub3qks2i	24	13	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	24	14	through	through	IN
work_624qrp646zf4pdga57ub3qks2i	24	15	necrosis	necrosis	NN
work_624qrp646zf4pdga57ub3qks2i	24	16	,	,	,
work_624qrp646zf4pdga57ub3qks2i	24	17	while	while	IN
work_624qrp646zf4pdga57ub3qks2i	24	18	�	�	JJ
work_624qrp646zf4pdga57ub3qks2i	24	19	-cell	-cell	JJ
work_624qrp646zf4pdga57ub3qks2i	24	20	destruction	destruction	NN
work_624qrp646zf4pdga57ub3qks2i	24	21	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	24	22	T1DM	T1DM	NNP
work_624qrp646zf4pdga57ub3qks2i	24	23	predominantly	predominantly	RB
work_624qrp646zf4pdga57ub3qks2i	24	24	proceeds	proceed	VBZ
work_624qrp646zf4pdga57ub3qks2i	24	25	through	through	IN
work_624qrp646zf4pdga57ub3qks2i	24	26	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	24	27	cytokine	cytokine	NN
work_624qrp646zf4pdga57ub3qks2i	24	28	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	24	29	mediated	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	24	30	apopto-	apopto-	NN
work_624qrp646zf4pdga57ub3qks2i	24	31	sis	sis	NN
work_624qrp646zf4pdga57ub3qks2i	24	32	process	process	NN
work_624qrp646zf4pdga57ub3qks2i	24	33	.	.	.
work_624qrp646zf4pdga57ub3qks2i	25	1	Interestingly	interestingly	RB
work_624qrp646zf4pdga57ub3qks2i	25	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	25	3	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	25	4	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	25	5	cleaved	cleave	VBN
work_624qrp646zf4pdga57ub3qks2i	25	6	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	25	7	inactivated	inactivate	VBN
work_624qrp646zf4pdga57ub3qks2i	25	8	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	25	9	caspase-3	caspase-3	NNP
work_624qrp646zf4pdga57ub3qks2i	25	10	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	25	11	-7	-7	:
work_624qrp646zf4pdga57ub3qks2i	25	12	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	25	13	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	25	14	early	early	JJ
work_624qrp646zf4pdga57ub3qks2i	25	15	phase	phase	NN
work_624qrp646zf4pdga57ub3qks2i	25	16	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	25	17	apoptosis	apoptosis	NN
work_624qrp646zf4pdga57ub3qks2i	25	18	,	,	,
work_624qrp646zf4pdga57ub3qks2i	25	19	suggesting	suggest	VBG
work_624qrp646zf4pdga57ub3qks2i	25	20	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	25	21	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	25	22	does	do	VBZ
work_624qrp646zf4pdga57ub3qks2i	25	23	not	not	RB
work_624qrp646zf4pdga57ub3qks2i	25	24	participate	participate	VB
work_624qrp646zf4pdga57ub3qks2i	25	25	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	25	26	this	this	DT
work_624qrp646zf4pdga57ub3qks2i	25	27	mode	mode	NN
work_624qrp646zf4pdga57ub3qks2i	25	28	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	25	29	cell	cell	NN
work_624qrp646zf4pdga57ub3qks2i	25	30	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	25	31	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	25	32	8)	8)	CD
work_624qrp646zf4pdga57ub3qks2i	25	33	.	.	.
work_624qrp646zf4pdga57ub3qks2i	26	1	Furthermore	furthermore	RB
work_624qrp646zf4pdga57ub3qks2i	26	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	26	3	Heller	Heller	NNP
work_624qrp646zf4pdga57ub3qks2i	26	4	et	et	NNP
work_624qrp646zf4pdga57ub3qks2i	26	5	al	al	NNP
work_624qrp646zf4pdga57ub3qks2i	26	6	.	.	.
work_624qrp646zf4pdga57ub3qks2i	27	1	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	27	2	6	6	CD
work_624qrp646zf4pdga57ub3qks2i	27	3	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	27	4	,	,	,
work_624qrp646zf4pdga57ub3qks2i	27	5	as	as	RB
work_624qrp646zf4pdga57ub3qks2i	27	6	early	early	RB
work_624qrp646zf4pdga57ub3qks2i	27	7	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	27	8	1995	1995	CD
work_624qrp646zf4pdga57ub3qks2i	27	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	27	10	demonstrated	demonstrate	VBD
work_624qrp646zf4pdga57ub3qks2i	27	11	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	27	12	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	27	13	isolated	isolate	VBN
work_624qrp646zf4pdga57ub3qks2i	27	14	from	from	IN
work_624qrp646zf4pdga57ub3qks2i	27	15	PARP-1-deficient	parp-1-deficient	JJ
work_624qrp646zf4pdga57ub3qks2i	27	16	mice	mouse	NNS
work_624qrp646zf4pdga57ub3qks2i	27	17	were	be	VBD
work_624qrp646zf4pdga57ub3qks2i	27	18	as	as	RB
work_624qrp646zf4pdga57ub3qks2i	27	19	sensi-	sensi-	JJ
work_624qrp646zf4pdga57ub3qks2i	27	20	tive	tive	JJ
work_624qrp646zf4pdga57ub3qks2i	27	21	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	27	22	control	control	NN
work_624qrp646zf4pdga57ub3qks2i	27	23	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	27	24	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	27	25	cell	cell	VB
work_624qrp646zf4pdga57ub3qks2i	27	26	lysis	lysis	NN
work_624qrp646zf4pdga57ub3qks2i	27	27	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	27	28	high	high	JJ
work_624qrp646zf4pdga57ub3qks2i	27	29	concentrations	concentration	NNS
work_624qrp646zf4pdga57ub3qks2i	27	30	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	27	31	NO	NO	NNP
work_624qrp646zf4pdga57ub3qks2i	27	32	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	27	33	reactive	reactive	JJ
work_624qrp646zf4pdga57ub3qks2i	27	34	oxygen	oxygen	NN
work_624qrp646zf4pdga57ub3qks2i	27	35	species	specie	NNS
work_624qrp646zf4pdga57ub3qks2i	27	36	.	.	.
work_624qrp646zf4pdga57ub3qks2i	28	1	These	these	DT
work_624qrp646zf4pdga57ub3qks2i	28	2	data	datum	NNS
work_624qrp646zf4pdga57ub3qks2i	28	3	clearly	clearly	RB
work_624qrp646zf4pdga57ub3qks2i	28	4	raise	raise	VBP
work_624qrp646zf4pdga57ub3qks2i	28	5	serious	serious	JJ
work_624qrp646zf4pdga57ub3qks2i	28	6	doubts	doubt	NNS
work_624qrp646zf4pdga57ub3qks2i	28	7	about	about	IN
work_624qrp646zf4pdga57ub3qks2i	28	8	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	28	9	importance	importance	NN
work_624qrp646zf4pdga57ub3qks2i	28	10	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	28	11	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	28	12	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	28	13	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	28	14	key	key	JJ
work_624qrp646zf4pdga57ub3qks2i	28	15	actor	actor	NN
work_624qrp646zf4pdga57ub3qks2i	28	16	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	28	17	�	�	JJ
work_624qrp646zf4pdga57ub3qks2i	28	18	-cell	-cell	JJ
work_624qrp646zf4pdga57ub3qks2i	28	19	destruction	destruction	NN
work_624qrp646zf4pdga57ub3qks2i	28	20	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	28	21	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	28	22	setting	setting	NN
work_624qrp646zf4pdga57ub3qks2i	28	23	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	28	24	T1DM	T1DM	NNP
work_624qrp646zf4pdga57ub3qks2i	28	25	.	.	.
work_624qrp646zf4pdga57ub3qks2i	29	1	Thus	thus	RB
work_624qrp646zf4pdga57ub3qks2i	29	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	29	3	although	although	IN
work_624qrp646zf4pdga57ub3qks2i	29	4	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	29	5	role	role	NN
work_624qrp646zf4pdga57ub3qks2i	29	6	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	29	7	PARP-1	parp-1	NN
work_624qrp646zf4pdga57ub3qks2i	29	8	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	29	9	�	�	JJ
work_624qrp646zf4pdga57ub3qks2i	29	10	-cell	-cell	JJ
work_624qrp646zf4pdga57ub3qks2i	29	11	destruction	destruction	NN
work_624qrp646zf4pdga57ub3qks2i	29	12	via	via	IN
work_624qrp646zf4pdga57ub3qks2i	29	13	necrosis	necrosis	NN
work_624qrp646zf4pdga57ub3qks2i	29	14	has	have	VBZ
work_624qrp646zf4pdga57ub3qks2i	29	15	been	be	VBN
work_624qrp646zf4pdga57ub3qks2i	29	16	irrefutably	irrefutably	RB
work_624qrp646zf4pdga57ub3qks2i	29	17	associated	associate	VBN
work_624qrp646zf4pdga57ub3qks2i	29	18	with	with	IN
work_624qrp646zf4pdga57ub3qks2i	29	19	STZ	stz	NN
work_624qrp646zf4pdga57ub3qks2i	29	20	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	29	21	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	29	22	establishing	establish	VBG
work_624qrp646zf4pdga57ub3qks2i	29	23	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	29	24	validity	validity	NN
work_624qrp646zf4pdga57ub3qks2i	29	25	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	29	26	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	29	27	Okamoto	Okamoto	NNP
work_624qrp646zf4pdga57ub3qks2i	29	28	model	model	NN
work_624qrp646zf4pdga57ub3qks2i	29	29	,	,	,
work_624qrp646zf4pdga57ub3qks2i	29	30	its	-PRON-	PRP$
work_624qrp646zf4pdga57ub3qks2i	29	31	role	role	NN
work_624qrp646zf4pdga57ub3qks2i	29	32	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	29	33	cytokine	cytokine	NN
work_624qrp646zf4pdga57ub3qks2i	29	34	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	29	35	mediated	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	29	36	cell	cell	NN
work_624qrp646zf4pdga57ub3qks2i	29	37	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	29	38	re-	re-	RB
work_624qrp646zf4pdga57ub3qks2i	29	39	mains	main	VBZ
work_624qrp646zf4pdga57ub3qks2i	29	40	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	29	41	be	be	VB
work_624qrp646zf4pdga57ub3qks2i	29	42	fully	fully	RB
work_624qrp646zf4pdga57ub3qks2i	29	43	explored	explore	VBN
work_624qrp646zf4pdga57ub3qks2i	29	44	.	.	.
work_624qrp646zf4pdga57ub3qks2i	30	1	In	in	IN
work_624qrp646zf4pdga57ub3qks2i	30	2	this	this	DT
work_624qrp646zf4pdga57ub3qks2i	30	3	issue	issue	NN
work_624qrp646zf4pdga57ub3qks2i	30	4	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	30	5	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	30	6	Journal	Journal	NNP
work_624qrp646zf4pdga57ub3qks2i	30	7	,	,	,
work_624qrp646zf4pdga57ub3qks2i	30	8	Andreone	Andreone	NNP
work_624qrp646zf4pdga57ub3qks2i	30	9	et	et	FW
work_624qrp646zf4pdga57ub3qks2i	30	10	al	al	NNP
work_624qrp646zf4pdga57ub3qks2i	30	11	.	.	.
work_624qrp646zf4pdga57ub3qks2i	31	1	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	31	2	1	1	LS
work_624qrp646zf4pdga57ub3qks2i	31	3	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	31	4	address	address	NN
work_624qrp646zf4pdga57ub3qks2i	31	5	this	this	DT
work_624qrp646zf4pdga57ub3qks2i	31	6	gap	gap	NN
work_624qrp646zf4pdga57ub3qks2i	31	7	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	31	8	challenge	challenge	VB
work_624qrp646zf4pdga57ub3qks2i	31	9	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	31	10	Okamoto	Okamoto	NNP
work_624qrp646zf4pdga57ub3qks2i	31	11	model	model	NN
work_624qrp646zf4pdga57ub3qks2i	31	12	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	31	13	demonstrating	demonstrate	VBG
work_624qrp646zf4pdga57ub3qks2i	31	14	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	31	15	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	31	16	does	do	VBZ
work_624qrp646zf4pdga57ub3qks2i	31	17	not	not	RB
work_624qrp646zf4pdga57ub3qks2i	31	18	participate	participate	VB
work_624qrp646zf4pdga57ub3qks2i	31	19	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	31	20	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	31	21	deleterious	deleterious	JJ
work_624qrp646zf4pdga57ub3qks2i	31	22	effect	effect	NN
work_624qrp646zf4pdga57ub3qks2i	31	23	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	31	24	cyto-	cyto-	NNP
work_624qrp646zf4pdga57ub3qks2i	31	25	kines	kine	NNS
work_624qrp646zf4pdga57ub3qks2i	31	26	on	on	IN
work_624qrp646zf4pdga57ub3qks2i	31	27	islet	islet	NN
work_624qrp646zf4pdga57ub3qks2i	31	28	function	function	NN
work_624qrp646zf4pdga57ub3qks2i	31	29	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	31	30	,	,	,
work_624qrp646zf4pdga57ub3qks2i	31	31	potentially	potentially	RB
work_624qrp646zf4pdga57ub3qks2i	31	32	,	,	,
work_624qrp646zf4pdga57ub3qks2i	31	33	survival	survival	NN
work_624qrp646zf4pdga57ub3qks2i	31	34	.	.	.
work_624qrp646zf4pdga57ub3qks2i	32	1	Indeed	indeed	RB
work_624qrp646zf4pdga57ub3qks2i	32	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	32	3	An-	an-	CC
work_624qrp646zf4pdga57ub3qks2i	32	4	dreone	dreone	NN
work_624qrp646zf4pdga57ub3qks2i	32	5	et	et	NNP
work_624qrp646zf4pdga57ub3qks2i	32	6	al	al	NNP
work_624qrp646zf4pdga57ub3qks2i	32	7	.	.	.
work_624qrp646zf4pdga57ub3qks2i	33	1	demonstrate	demonstrate	VB
work_624qrp646zf4pdga57ub3qks2i	33	2	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	33	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	33	4	similar	similar	JJ
work_624qrp646zf4pdga57ub3qks2i	33	5	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	33	6	control	control	VB
work_624qrp646zf4pdga57ub3qks2i	33	7	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	33	8	,	,	,
work_624qrp646zf4pdga57ub3qks2i	33	9	PARP-	PARP-	NNS
work_624qrp646zf4pdga57ub3qks2i	33	10	1-deficient	1-deficient	CD
work_624qrp646zf4pdga57ub3qks2i	33	11	islet	islet	NN
work_624qrp646zf4pdga57ub3qks2i	33	12	cells	cell	NNS
work_624qrp646zf4pdga57ub3qks2i	33	13	exposed	expose	VBN
work_624qrp646zf4pdga57ub3qks2i	33	14	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	33	15	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	33	16	proinflammatory	proinflammatory	JJ
work_624qrp646zf4pdga57ub3qks2i	33	17	cytokines	cytokine	NNS
work_624qrp646zf4pdga57ub3qks2i	33	18	IL-1	IL-1	NNP
work_624qrp646zf4pdga57ub3qks2i	33	19	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	33	20	IFN-	IFN-	NNP
work_624qrp646zf4pdga57ub3qks2i	33	21	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	33	22	exhibit	exhibit	VBP
work_624qrp646zf4pdga57ub3qks2i	33	23	normal	normal	JJ
work_624qrp646zf4pdga57ub3qks2i	33	24	activation	activation	NN
work_624qrp646zf4pdga57ub3qks2i	33	25	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	33	26	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	33	27	NF-	NF-	NNP
work_624qrp646zf4pdga57ub3qks2i	33	28	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	33	29	B	B	NNP
work_624qrp646zf4pdga57ub3qks2i	33	30	sig-	sig-	JJ
work_624qrp646zf4pdga57ub3qks2i	33	31	naling	naling	NN
work_624qrp646zf4pdga57ub3qks2i	33	32	pathway	pathway	NN
work_624qrp646zf4pdga57ub3qks2i	33	33	,	,	,
work_624qrp646zf4pdga57ub3qks2i	33	34	which	which	WDT
work_624qrp646zf4pdga57ub3qks2i	33	35	leads	lead	VBZ
work_624qrp646zf4pdga57ub3qks2i	33	36	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	33	37	induction	induction	NN
work_624qrp646zf4pdga57ub3qks2i	33	38	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	33	39	iNOS	iNOS	NNP
work_624qrp646zf4pdga57ub3qks2i	33	40	expression	expression	NN
work_624qrp646zf4pdga57ub3qks2i	33	41	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	33	42	production	production	NN
work_624qrp646zf4pdga57ub3qks2i	33	43	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	33	44	NO	no	UH
work_624qrp646zf4pdga57ub3qks2i	33	45	.	.	.
work_624qrp646zf4pdga57ub3qks2i	34	1	Furthermore	furthermore	RB
work_624qrp646zf4pdga57ub3qks2i	34	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	34	3	deletion	deletion	NN
work_624qrp646zf4pdga57ub3qks2i	34	4	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	34	5	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	34	6	did	do	VBD
work_624qrp646zf4pdga57ub3qks2i	34	7	not	not	RB
work_624qrp646zf4pdga57ub3qks2i	34	8	alter	alter	VB
work_624qrp646zf4pdga57ub3qks2i	34	9	IL-1	IL-1	NNP
work_624qrp646zf4pdga57ub3qks2i	34	10	/	/	SYM
work_624qrp646zf4pdga57ub3qks2i	34	11	IFN-	IFN-	NNP
work_624qrp646zf4pdga57ub3qks2i	34	12	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	34	13	-mediated	-mediated	JJ
work_624qrp646zf4pdga57ub3qks2i	34	14	phosphorylation	phosphorylation	NN
work_624qrp646zf4pdga57ub3qks2i	34	15	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	34	16	Stat-1	Stat-1	NNP
work_624qrp646zf4pdga57ub3qks2i	34	17	,	,	,
work_624qrp646zf4pdga57ub3qks2i	34	18	indi-	indi-	NN
work_624qrp646zf4pdga57ub3qks2i	34	19	cating	cating	NN
work_624qrp646zf4pdga57ub3qks2i	34	20	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	34	21	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	34	22	Jak	Jak	NNP
work_624qrp646zf4pdga57ub3qks2i	34	23	/	/	SYM
work_624qrp646zf4pdga57ub3qks2i	34	24	Stat	Stat	NNP
work_624qrp646zf4pdga57ub3qks2i	34	25	signaling	signaling	NN
work_624qrp646zf4pdga57ub3qks2i	34	26	pathway	pathway	NN
work_624qrp646zf4pdga57ub3qks2i	34	27	implicated	implicate	VBN
work_624qrp646zf4pdga57ub3qks2i	34	28	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	34	29	apo-	apo-	NN
work_624qrp646zf4pdga57ub3qks2i	34	30	ptosis	ptosis	NN
work_624qrp646zf4pdga57ub3qks2i	34	31	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	34	32	activated	activate	VBN
work_624qrp646zf4pdga57ub3qks2i	34	33	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	34	34	cytokines	cytokine	NNS
work_624qrp646zf4pdga57ub3qks2i	34	35	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	34	36	PARP-1-deficient	parp-1-deficient	JJ
work_624qrp646zf4pdga57ub3qks2i	34	37	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	34	38	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	34	39	4	4	CD
work_624qrp646zf4pdga57ub3qks2i	34	40	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	34	41	.	.	.
work_624qrp646zf4pdga57ub3qks2i	35	1	Using	use	VBG
work_624qrp646zf4pdga57ub3qks2i	35	2	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	35	3	biochemical	biochemical	JJ
work_624qrp646zf4pdga57ub3qks2i	35	4	assay	assay	NN
work_624qrp646zf4pdga57ub3qks2i	35	5	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	35	6	measures	measure	NNS
work_624qrp646zf4pdga57ub3qks2i	35	7	uptake	uptake	JJ
work_624qrp646zf4pdga57ub3qks2i	35	8	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	35	9	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	35	10	neutral	neutral	JJ
work_624qrp646zf4pdga57ub3qks2i	35	11	red	red	JJ
work_624qrp646zf4pdga57ub3qks2i	35	12	dye	dye	NN
work_624qrp646zf4pdga57ub3qks2i	35	13	within	within	IN
work_624qrp646zf4pdga57ub3qks2i	35	14	acidic	acidic	JJ
work_624qrp646zf4pdga57ub3qks2i	35	15	lysosomes	lysosome	NNS
work_624qrp646zf4pdga57ub3qks2i	35	16	,	,	,
work_624qrp646zf4pdga57ub3qks2i	35	17	Andreone	Andreone	NNP
work_624qrp646zf4pdga57ub3qks2i	35	18	et	et	FW
work_624qrp646zf4pdga57ub3qks2i	35	19	al	al	NNP
work_624qrp646zf4pdga57ub3qks2i	35	20	.	.	.
work_624qrp646zf4pdga57ub3qks2i	36	1	show	show	VB
work_624qrp646zf4pdga57ub3qks2i	36	2	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	36	3	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	36	4	lacking	lack	VBG
work_624qrp646zf4pdga57ub3qks2i	36	5	PARP-1	PARP-1	NNS
work_624qrp646zf4pdga57ub3qks2i	36	6	are	be	VBP
work_624qrp646zf4pdga57ub3qks2i	36	7	resistant	resistant	JJ
work_624qrp646zf4pdga57ub3qks2i	36	8	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	36	9	cytokine	cytokine	VB
work_624qrp646zf4pdga57ub3qks2i	36	10	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	36	11	mediated	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	36	12	cyto-	cyto-	NNS
work_624qrp646zf4pdga57ub3qks2i	36	13	toxicity	toxicity	NN
work_624qrp646zf4pdga57ub3qks2i	36	14	,	,	,
work_624qrp646zf4pdga57ub3qks2i	36	15	whereas	whereas	IN
work_624qrp646zf4pdga57ub3qks2i	36	16	they	-PRON-	PRP
work_624qrp646zf4pdga57ub3qks2i	36	17	remain	remain	VBP
work_624qrp646zf4pdga57ub3qks2i	36	18	sensitive	sensitive	JJ
work_624qrp646zf4pdga57ub3qks2i	36	19	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	36	20	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	36	21	general	general	JJ
work_624qrp646zf4pdga57ub3qks2i	36	22	apoptotic	apoptotic	JJ
work_624qrp646zf4pdga57ub3qks2i	36	23	agent	agent	NN
work_624qrp646zf4pdga57ub3qks2i	36	24	staurosporine	staurosporine	NN
work_624qrp646zf4pdga57ub3qks2i	36	25	.	.	.
work_624qrp646zf4pdga57ub3qks2i	37	1	As	as	IN
work_624qrp646zf4pdga57ub3qks2i	37	2	lysosome	lysosome	JJ
work_624qrp646zf4pdga57ub3qks2i	37	3	acidification	acidification	NN
work_624qrp646zf4pdga57ub3qks2i	37	4	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	37	5	an	an	DT
work_624qrp646zf4pdga57ub3qks2i	37	6	ATP-	ATP-	NNP
work_624qrp646zf4pdga57ub3qks2i	37	7	dependent	dependent	JJ
work_624qrp646zf4pdga57ub3qks2i	37	8	process	process	NN
work_624qrp646zf4pdga57ub3qks2i	37	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	37	10	which	which	WDT
work_624qrp646zf4pdga57ub3qks2i	37	11	may	may	MD
work_624qrp646zf4pdga57ub3qks2i	37	12	be	be	VB
work_624qrp646zf4pdga57ub3qks2i	37	13	preserved	preserve	VBN
work_624qrp646zf4pdga57ub3qks2i	37	14	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	37	15	PARP-1-defi-	parp-1-defi-	JJ
work_624qrp646zf4pdga57ub3qks2i	37	16	cient	cient	NN
work_624qrp646zf4pdga57ub3qks2i	37	17	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	37	18	due	due	JJ
work_624qrp646zf4pdga57ub3qks2i	37	19	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	37	20	sustained	sustained	JJ
work_624qrp646zf4pdga57ub3qks2i	37	21	levels	level	NNS
work_624qrp646zf4pdga57ub3qks2i	37	22	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	37	23	ATP	ATP	NNP
work_624qrp646zf4pdga57ub3qks2i	37	24	,	,	,
work_624qrp646zf4pdga57ub3qks2i	37	25	Andreone	Andreone	NNP
work_624qrp646zf4pdga57ub3qks2i	37	26	et	et	FW
work_624qrp646zf4pdga57ub3qks2i	37	27	al	al	NNP
work_624qrp646zf4pdga57ub3qks2i	37	28	.	.	.
work_624qrp646zf4pdga57ub3qks2i	38	1	astutely	astutely	RB
work_624qrp646zf4pdga57ub3qks2i	38	2	used	use	VBD
work_624qrp646zf4pdga57ub3qks2i	38	3	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	38	4	terminal	terminal	NNP
work_624qrp646zf4pdga57ub3qks2i	38	5	deoxynucleotidyl	deoxynucleotidyl	NN
work_624qrp646zf4pdga57ub3qks2i	38	6	transferase	transferase	NN
work_624qrp646zf4pdga57ub3qks2i	38	7	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	38	8	medi-	medi-	NN
work_624qrp646zf4pdga57ub3qks2i	38	9	Address	address	NN
work_624qrp646zf4pdga57ub3qks2i	38	10	for	for	IN
work_624qrp646zf4pdga57ub3qks2i	38	11	reprint	reprint	NN
work_624qrp646zf4pdga57ub3qks2i	38	12	requests	request	NNS
work_624qrp646zf4pdga57ub3qks2i	38	13	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	38	14	other	other	JJ
work_624qrp646zf4pdga57ub3qks2i	38	15	correspondence	correspondence	NN
work_624qrp646zf4pdga57ub3qks2i	38	16	:	:	:
work_624qrp646zf4pdga57ub3qks2i	38	17	B.	B.	NNP
work_624qrp646zf4pdga57ub3qks2i	38	18	R.	R.	NNP
work_624qrp646zf4pdga57ub3qks2i	38	19	Gauthier	Gauthier	NNP
work_624qrp646zf4pdga57ub3qks2i	38	20	,	,	,
work_624qrp646zf4pdga57ub3qks2i	38	21	Pancreatic	Pancreatic	NNP
work_624qrp646zf4pdga57ub3qks2i	38	22	Islet	Islet	NNP
work_624qrp646zf4pdga57ub3qks2i	38	23	Development	Development	NNP
work_624qrp646zf4pdga57ub3qks2i	38	24	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	38	25	Regeneration	Regeneration	NNP
work_624qrp646zf4pdga57ub3qks2i	38	26	Unit	Unit	NNP
work_624qrp646zf4pdga57ub3qks2i	38	27	,	,	,
work_624qrp646zf4pdga57ub3qks2i	38	28	Dept	Dept	NNP
work_624qrp646zf4pdga57ub3qks2i	38	29	.	.	.
work_624qrp646zf4pdga57ub3qks2i	39	1	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	39	2	Stem	Stem	NNP
work_624qrp646zf4pdga57ub3qks2i	39	3	Cells	Cells	NNPS
work_624qrp646zf4pdga57ub3qks2i	39	4	,	,	,
work_624qrp646zf4pdga57ub3qks2i	39	5	CABIMER	CABIMER	NNP
work_624qrp646zf4pdga57ub3qks2i	39	6	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	39	7	Andalusian	Andalusian	NNP
work_624qrp646zf4pdga57ub3qks2i	39	8	Center	Center	NNP
work_624qrp646zf4pdga57ub3qks2i	39	9	for	for	IN
work_624qrp646zf4pdga57ub3qks2i	39	10	Molecular	Molecular	NNP
work_624qrp646zf4pdga57ub3qks2i	39	11	Biology	Biology	NNP
work_624qrp646zf4pdga57ub3qks2i	39	12	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	39	13	Regenerative	Regenerative	NNP
work_624qrp646zf4pdga57ub3qks2i	39	14	Med-	Med-	NNP
work_624qrp646zf4pdga57ub3qks2i	39	15	icine	icine	NN
work_624qrp646zf4pdga57ub3qks2i	39	16	,	,	,
work_624qrp646zf4pdga57ub3qks2i	39	17	Avda	Avda	NNP
work_624qrp646zf4pdga57ub3qks2i	39	18	Américo	Américo	NNP
work_624qrp646zf4pdga57ub3qks2i	39	19	Vespucio	Vespucio	NNP
work_624qrp646zf4pdga57ub3qks2i	39	20	,	,	,
work_624qrp646zf4pdga57ub3qks2i	39	21	Parque	Parque	NNP
work_624qrp646zf4pdga57ub3qks2i	39	22	Científico	Científico	NNP
work_624qrp646zf4pdga57ub3qks2i	39	23	y	y	NNP
work_624qrp646zf4pdga57ub3qks2i	39	24	Tecnológico	Tecnológico	NNP
work_624qrp646zf4pdga57ub3qks2i	39	25	Cartuja	Cartuja	NNP
work_624qrp646zf4pdga57ub3qks2i	39	26	93	93	CD
work_624qrp646zf4pdga57ub3qks2i	39	27	,	,	,
work_624qrp646zf4pdga57ub3qks2i	39	28	41092	41092	CD
work_624qrp646zf4pdga57ub3qks2i	39	29	Seville	Seville	NNP
work_624qrp646zf4pdga57ub3qks2i	39	30	,	,	,
work_624qrp646zf4pdga57ub3qks2i	39	31	Spain	Spain	NNP
work_624qrp646zf4pdga57ub3qks2i	39	32	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	39	33	e	e	NN
work_624qrp646zf4pdga57ub3qks2i	39	34	-	-	NN
work_624qrp646zf4pdga57ub3qks2i	39	35	mail	mail	NN
work_624qrp646zf4pdga57ub3qks2i	39	36	:	:	:
work_624qrp646zf4pdga57ub3qks2i	39	37	benoit.gauthier@cabimer.es	benoit.gauthier@cabimer.es	LS
work_624qrp646zf4pdga57ub3qks2i	39	38	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	39	39	.	.	.
work_624qrp646zf4pdga57ub3qks2i	40	1	Am	Am	NNP
work_624qrp646zf4pdga57ub3qks2i	40	2	J	J	NNP
work_624qrp646zf4pdga57ub3qks2i	40	3	Physiol	Physiol	NNP
work_624qrp646zf4pdga57ub3qks2i	40	4	Endocrinol	Endocrinol	NNP
work_624qrp646zf4pdga57ub3qks2i	40	5	Metab	Metab	NNP
work_624qrp646zf4pdga57ub3qks2i	40	6	303	303	CD
work_624qrp646zf4pdga57ub3qks2i	40	7	:	:	:
work_624qrp646zf4pdga57ub3qks2i	40	8	E170–E171	E170–E171	NNP
work_624qrp646zf4pdga57ub3qks2i	40	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	40	10	2012	2012	CD
work_624qrp646zf4pdga57ub3qks2i	40	11	;	;	:
work_624qrp646zf4pdga57ub3qks2i	40	12	doi:10.1152	doi:10.1152	NNP
work_624qrp646zf4pdga57ub3qks2i	40	13	/	/	SYM
work_624qrp646zf4pdga57ub3qks2i	40	14	ajpendo.00226.2012.Editorial	ajpendo.00226.2012.Editorial	NNP
work_624qrp646zf4pdga57ub3qks2i	40	15	Focus	Focus	NNP
work_624qrp646zf4pdga57ub3qks2i	40	16	0193	0193	CD
work_624qrp646zf4pdga57ub3qks2i	40	17	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	40	18	1849/12	1849/12	CD
work_624qrp646zf4pdga57ub3qks2i	40	19	Copyright	copyright	NN
work_624qrp646zf4pdga57ub3qks2i	40	20	©	©	NN
work_624qrp646zf4pdga57ub3qks2i	40	21	2012	2012	CD
work_624qrp646zf4pdga57ub3qks2i	40	22	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	40	23	American	American	NNP
work_624qrp646zf4pdga57ub3qks2i	40	24	Physiological	Physiological	NNP
work_624qrp646zf4pdga57ub3qks2i	40	25	Society	Society	NNP
work_624qrp646zf4pdga57ub3qks2i	40	26	http://www.ajpendo.orgE170	http://www.ajpendo.orgE170	NNP
work_624qrp646zf4pdga57ub3qks2i	40	27	Downloaded	download	VBN
work_624qrp646zf4pdga57ub3qks2i	40	28	from	from	IN
work_624qrp646zf4pdga57ub3qks2i	40	29	journals.physiology.org/journal/ajpendo	journals.physiology.org/journal/ajpendo	NNS
work_624qrp646zf4pdga57ub3qks2i	40	30	at	at	IN
work_624qrp646zf4pdga57ub3qks2i	40	31	Carnegie	Carnegie	NNP
work_624qrp646zf4pdga57ub3qks2i	40	32	Mellon	Mellon	NNP
work_624qrp646zf4pdga57ub3qks2i	40	33	Univ	Univ	NNP
work_624qrp646zf4pdga57ub3qks2i	40	34	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	40	35	128.182.081.034	128.182.081.034	CD
work_624qrp646zf4pdga57ub3qks2i	40	36	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	40	37	on	on	IN
work_624qrp646zf4pdga57ub3qks2i	40	38	April	April	NNP
work_624qrp646zf4pdga57ub3qks2i	40	39	5	5	CD
work_624qrp646zf4pdga57ub3qks2i	40	40	,	,	,
work_624qrp646zf4pdga57ub3qks2i	40	41	2021	2021	CD
work_624qrp646zf4pdga57ub3qks2i	40	42	.	.	.
work_624qrp646zf4pdga57ub3qks2i	40	43	ated	ated	JJ
work_624qrp646zf4pdga57ub3qks2i	40	44	dUTP	dUTP	NNP
work_624qrp646zf4pdga57ub3qks2i	40	45	nick	nick	NN
work_624qrp646zf4pdga57ub3qks2i	40	46	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	40	47	end	end	NN
work_624qrp646zf4pdga57ub3qks2i	40	48	labeling	labeling	NN
work_624qrp646zf4pdga57ub3qks2i	40	49	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	40	50	TUNEL	TUNEL	NNP
work_624qrp646zf4pdga57ub3qks2i	40	51	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	40	52	assay	assay	NN
work_624qrp646zf4pdga57ub3qks2i	40	53	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	40	54	an	an	DT
work_624qrp646zf4pdga57ub3qks2i	40	55	alternative	alternative	JJ
work_624qrp646zf4pdga57ub3qks2i	40	56	approach	approach	NN
work_624qrp646zf4pdga57ub3qks2i	40	57	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	40	58	evaluate	evaluate	VB
work_624qrp646zf4pdga57ub3qks2i	40	59	cell	cell	NN
work_624qrp646zf4pdga57ub3qks2i	40	60	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	40	61	.	.	.
work_624qrp646zf4pdga57ub3qks2i	41	1	The	the	DT
work_624qrp646zf4pdga57ub3qks2i	41	2	TUNEL	tunel	JJ
work_624qrp646zf4pdga57ub3qks2i	41	3	assay	assay	NN
work_624qrp646zf4pdga57ub3qks2i	41	4	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	41	5	particu-	particu-	VBG
work_624qrp646zf4pdga57ub3qks2i	41	6	larly	larly	RB
work_624qrp646zf4pdga57ub3qks2i	41	7	useful	useful	JJ
work_624qrp646zf4pdga57ub3qks2i	41	8	,	,	,
work_624qrp646zf4pdga57ub3qks2i	41	9	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	41	10	it	-PRON-	PRP
work_624qrp646zf4pdga57ub3qks2i	41	11	reveals	reveal	VBZ
work_624qrp646zf4pdga57ub3qks2i	41	12	DNA	dna	NN
work_624qrp646zf4pdga57ub3qks2i	41	13	strand	strand	NN
work_624qrp646zf4pdga57ub3qks2i	41	14	breaks	break	NNS
work_624qrp646zf4pdga57ub3qks2i	41	15	,	,	,
work_624qrp646zf4pdga57ub3qks2i	41	16	which	which	WDT
work_624qrp646zf4pdga57ub3qks2i	41	17	are	be	VBP
work_624qrp646zf4pdga57ub3qks2i	41	18	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	41	19	hallmark	hallmark	NN
work_624qrp646zf4pdga57ub3qks2i	41	20	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	41	21	NO	no	RB
work_624qrp646zf4pdga57ub3qks2i	41	22	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	41	23	mediated	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	41	24	cell	cell	NN
work_624qrp646zf4pdga57ub3qks2i	41	25	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	41	26	.	.	.
work_624qrp646zf4pdga57ub3qks2i	42	1	Consistent	consistent	JJ
work_624qrp646zf4pdga57ub3qks2i	42	2	with	with	IN
work_624qrp646zf4pdga57ub3qks2i	42	3	preserved	preserve	VBN
work_624qrp646zf4pdga57ub3qks2i	42	4	NO	no	DT
work_624qrp646zf4pdga57ub3qks2i	42	5	production	production	NN
work_624qrp646zf4pdga57ub3qks2i	42	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	42	7	PARP-1-deficient	parp-1-deficient	JJ
work_624qrp646zf4pdga57ub3qks2i	42	8	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	42	9	exhibited	exhibit	VBN
work_624qrp646zf4pdga57ub3qks2i	42	10	increased	increase	VBD
work_624qrp646zf4pdga57ub3qks2i	42	11	TUNEL	tunel	JJ
work_624qrp646zf4pdga57ub3qks2i	42	12	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	42	13	positive	positive	JJ
work_624qrp646zf4pdga57ub3qks2i	42	14	cells	cell	NNS
work_624qrp646zf4pdga57ub3qks2i	42	15	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	42	16	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	42	17	presence	presence	NN
work_624qrp646zf4pdga57ub3qks2i	42	18	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	42	19	cytokines	cytokine	NNS
work_624qrp646zf4pdga57ub3qks2i	42	20	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	42	21	levels	level	NNS
work_624qrp646zf4pdga57ub3qks2i	42	22	similar	similar	JJ
work_624qrp646zf4pdga57ub3qks2i	42	23	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	42	24	those	those	DT
work_624qrp646zf4pdga57ub3qks2i	42	25	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	42	26	treated	treated	JJ
work_624qrp646zf4pdga57ub3qks2i	42	27	control	control	NN
work_624qrp646zf4pdga57ub3qks2i	42	28	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	42	29	.	.	.
work_624qrp646zf4pdga57ub3qks2i	43	1	Consequently	consequently	RB
work_624qrp646zf4pdga57ub3qks2i	43	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	43	3	glu-	glu-	VBZ
work_624qrp646zf4pdga57ub3qks2i	43	4	cose	cose	NN
work_624qrp646zf4pdga57ub3qks2i	43	5	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	43	6	induced	induce	VBN
work_624qrp646zf4pdga57ub3qks2i	43	7	insulin	insulin	NN
work_624qrp646zf4pdga57ub3qks2i	43	8	secretion	secretion	NN
work_624qrp646zf4pdga57ub3qks2i	43	9	was	be	VBD
work_624qrp646zf4pdga57ub3qks2i	43	10	also	also	RB
work_624qrp646zf4pdga57ub3qks2i	43	11	impaired	impair	VBN
work_624qrp646zf4pdga57ub3qks2i	43	12	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	43	13	PARP-1-	parp-1-	NN
work_624qrp646zf4pdga57ub3qks2i	43	14	lacking	lack	VBG
work_624qrp646zf4pdga57ub3qks2i	43	15	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	43	16	treated	treat	VBN
work_624qrp646zf4pdga57ub3qks2i	43	17	with	with	IN
work_624qrp646zf4pdga57ub3qks2i	43	18	cytokine	cytokine	NN
work_624qrp646zf4pdga57ub3qks2i	43	19	.	.	.
work_624qrp646zf4pdga57ub3qks2i	44	1	As	as	IN
work_624qrp646zf4pdga57ub3qks2i	44	2	development	development	NN
work_624qrp646zf4pdga57ub3qks2i	44	3	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	44	4	T1DM	T1DM	NNP
work_624qrp646zf4pdga57ub3qks2i	44	5	results	result	NNS
work_624qrp646zf4pdga57ub3qks2i	44	6	from	from	IN
work_624qrp646zf4pdga57ub3qks2i	44	7	an	an	DT
work_624qrp646zf4pdga57ub3qks2i	44	8	intricate	intricate	JJ
work_624qrp646zf4pdga57ub3qks2i	44	9	cross	cross	NN
work_624qrp646zf4pdga57ub3qks2i	44	10	talk	talk	NN
work_624qrp646zf4pdga57ub3qks2i	44	11	between	between	IN
work_624qrp646zf4pdga57ub3qks2i	44	12	immune	immune	JJ
work_624qrp646zf4pdga57ub3qks2i	44	13	cells	cell	NNS
work_624qrp646zf4pdga57ub3qks2i	44	14	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	44	15	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	44	16	,	,	,
work_624qrp646zf4pdga57ub3qks2i	44	17	Andreone	Andreone	NNP
work_624qrp646zf4pdga57ub3qks2i	44	18	et	et	FW
work_624qrp646zf4pdga57ub3qks2i	44	19	al	al	NNP
work_624qrp646zf4pdga57ub3qks2i	44	20	.	.	.
work_624qrp646zf4pdga57ub3qks2i	45	1	also	also	RB
work_624qrp646zf4pdga57ub3qks2i	45	2	assessed	assess	VBN
work_624qrp646zf4pdga57ub3qks2i	45	3	whether	whether	IN
work_624qrp646zf4pdga57ub3qks2i	45	4	inflammatory	inflammatory	JJ
work_624qrp646zf4pdga57ub3qks2i	45	5	cell	cell	NN
work_624qrp646zf4pdga57ub3qks2i	45	6	signaling	signaling	NN
work_624qrp646zf4pdga57ub3qks2i	45	7	was	be	VBD
work_624qrp646zf4pdga57ub3qks2i	45	8	impaired	impair	VBN
work_624qrp646zf4pdga57ub3qks2i	45	9	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	45	10	macrophages	macrophage	NNS
work_624qrp646zf4pdga57ub3qks2i	45	11	derived	derive	VBN
work_624qrp646zf4pdga57ub3qks2i	45	12	from	from	IN
work_624qrp646zf4pdga57ub3qks2i	45	13	PARP-	PARP-	NNS
work_624qrp646zf4pdga57ub3qks2i	45	14	deficient	deficient	JJ
work_624qrp646zf4pdga57ub3qks2i	45	15	mice	mouse	NNS
work_624qrp646zf4pdga57ub3qks2i	45	16	,	,	,
work_624qrp646zf4pdga57ub3qks2i	45	17	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	45	18	previously	previously	RB
work_624qrp646zf4pdga57ub3qks2i	45	19	reported	report	VBN
work_624qrp646zf4pdga57ub3qks2i	45	20	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	45	21	others	other	NNS
work_624qrp646zf4pdga57ub3qks2i	45	22	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	45	23	10	10	CD
work_624qrp646zf4pdga57ub3qks2i	45	24	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	45	25	.	.	.
work_624qrp646zf4pdga57ub3qks2i	46	1	Surpris-	Surpris-	NNP
work_624qrp646zf4pdga57ub3qks2i	46	2	ingly	ingly	RB
work_624qrp646zf4pdga57ub3qks2i	46	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	46	4	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	46	5	NF-	NF-	NNP
work_624qrp646zf4pdga57ub3qks2i	46	6	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	46	7	B	b	NN
work_624qrp646zf4pdga57ub3qks2i	46	8	signaling	signaling	NN
work_624qrp646zf4pdga57ub3qks2i	46	9	pathway	pathway	NN
work_624qrp646zf4pdga57ub3qks2i	46	10	,	,	,
work_624qrp646zf4pdga57ub3qks2i	46	11	as	as	RB
work_624qrp646zf4pdga57ub3qks2i	46	12	well	well	RB
work_624qrp646zf4pdga57ub3qks2i	46	13	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	46	14	downstream	downstream	JJ
work_624qrp646zf4pdga57ub3qks2i	46	15	iNOS	inos	NN
work_624qrp646zf4pdga57ub3qks2i	46	16	activation	activation	NN
work_624qrp646zf4pdga57ub3qks2i	46	17	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	46	18	NO	no	DT
work_624qrp646zf4pdga57ub3qks2i	46	19	production	production	NN
work_624qrp646zf4pdga57ub3qks2i	46	20	,	,	,
work_624qrp646zf4pdga57ub3qks2i	46	21	were	be	VBD
work_624qrp646zf4pdga57ub3qks2i	46	22	unaltered	unaltered	JJ
work_624qrp646zf4pdga57ub3qks2i	46	23	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	46	24	mac-	mac-	JJ
work_624qrp646zf4pdga57ub3qks2i	46	25	rophages	rophage	NNS
work_624qrp646zf4pdga57ub3qks2i	46	26	derived	derive	VBN
work_624qrp646zf4pdga57ub3qks2i	46	27	from	from	IN
work_624qrp646zf4pdga57ub3qks2i	46	28	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	46	29	knockout	knockout	NN
work_624qrp646zf4pdga57ub3qks2i	46	30	mice	mouse	NNS
work_624qrp646zf4pdga57ub3qks2i	46	31	that	that	WDT
work_624qrp646zf4pdga57ub3qks2i	46	32	were	be	VBD
work_624qrp646zf4pdga57ub3qks2i	46	33	ex-	ex-	RB
work_624qrp646zf4pdga57ub3qks2i	46	34	posed	pose	VBN
work_624qrp646zf4pdga57ub3qks2i	46	35	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	46	36	cytokines	cytokine	NNS
work_624qrp646zf4pdga57ub3qks2i	46	37	or	or	CC
work_624qrp646zf4pdga57ub3qks2i	46	38	LPS	LPS	NNP
work_624qrp646zf4pdga57ub3qks2i	46	39	.	.	.
work_624qrp646zf4pdga57ub3qks2i	47	1	A	a	DT
work_624qrp646zf4pdga57ub3qks2i	47	2	potential	potential	JJ
work_624qrp646zf4pdga57ub3qks2i	47	3	explanation	explanation	NN
work_624qrp646zf4pdga57ub3qks2i	47	4	for	for	IN
work_624qrp646zf4pdga57ub3qks2i	47	5	discrep-	discrep-	NN
work_624qrp646zf4pdga57ub3qks2i	47	6	ancies	ancie	NNS
work_624qrp646zf4pdga57ub3qks2i	47	7	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	47	8	results	result	NNS
work_624qrp646zf4pdga57ub3qks2i	47	9	may	may	MD
work_624qrp646zf4pdga57ub3qks2i	47	10	stem	stem	VB
work_624qrp646zf4pdga57ub3qks2i	47	11	from	from	IN
work_624qrp646zf4pdga57ub3qks2i	47	12	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	47	13	fact	fact	NN
work_624qrp646zf4pdga57ub3qks2i	47	14	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	47	15	previous	previous	JJ
work_624qrp646zf4pdga57ub3qks2i	47	16	studies	study	NNS
work_624qrp646zf4pdga57ub3qks2i	47	17	were	be	VBD
work_624qrp646zf4pdga57ub3qks2i	47	18	performed	perform	VBN
work_624qrp646zf4pdga57ub3qks2i	47	19	with	with	IN
work_624qrp646zf4pdga57ub3qks2i	47	20	macrophages	macrophage	NNS
work_624qrp646zf4pdga57ub3qks2i	47	21	exposed	expose	VBN
work_624qrp646zf4pdga57ub3qks2i	47	22	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	47	23	vivo	vivo	NNP
work_624qrp646zf4pdga57ub3qks2i	47	24	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	47	25	LPS	LPS	NNP
work_624qrp646zf4pdga57ub3qks2i	47	26	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	47	27	10	10	CD
work_624qrp646zf4pdga57ub3qks2i	47	28	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	47	29	,	,	,
work_624qrp646zf4pdga57ub3qks2i	47	30	while	while	IN
work_624qrp646zf4pdga57ub3qks2i	47	31	Andreone	Andreone	NNP
work_624qrp646zf4pdga57ub3qks2i	47	32	et	et	FW
work_624qrp646zf4pdga57ub3qks2i	47	33	al	al	NNP
work_624qrp646zf4pdga57ub3qks2i	47	34	.	.	.
work_624qrp646zf4pdga57ub3qks2i	48	1	studied	study	VBN
work_624qrp646zf4pdga57ub3qks2i	48	2	naïve	naïve	NNP
work_624qrp646zf4pdga57ub3qks2i	48	3	macrophages	macrophage	NNS
work_624qrp646zf4pdga57ub3qks2i	48	4	treated	treat	VBN
work_624qrp646zf4pdga57ub3qks2i	48	5	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	48	6	vitro	vitro	FW
work_624qrp646zf4pdga57ub3qks2i	48	7	with	with	IN
work_624qrp646zf4pdga57ub3qks2i	48	8	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	48	9	endotoxin	endotoxin	NN
work_624qrp646zf4pdga57ub3qks2i	48	10	.	.	.
work_624qrp646zf4pdga57ub3qks2i	49	1	The	the	DT
work_624qrp646zf4pdga57ub3qks2i	49	2	work	work	NN
work_624qrp646zf4pdga57ub3qks2i	49	3	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	49	4	Andreone	Andreone	NNP
work_624qrp646zf4pdga57ub3qks2i	49	5	et	et	FW
work_624qrp646zf4pdga57ub3qks2i	49	6	al	al	NNP
work_624qrp646zf4pdga57ub3qks2i	49	7	.	.	.
work_624qrp646zf4pdga57ub3qks2i	50	1	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	50	2	1	1	LS
work_624qrp646zf4pdga57ub3qks2i	50	3	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	50	4	demonstrates	demonstrate	VBZ
work_624qrp646zf4pdga57ub3qks2i	50	5	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	50	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	50	7	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	50	8	contrast	contrast	NN
work_624qrp646zf4pdga57ub3qks2i	50	9	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	50	10	STZ	stz	NN
work_624qrp646zf4pdga57ub3qks2i	50	11	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	50	12	mediated	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	50	13	cell	cell	NN
work_624qrp646zf4pdga57ub3qks2i	50	14	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	50	15	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	50	16	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	50	17	Okamoto	Okamoto	NNP
work_624qrp646zf4pdga57ub3qks2i	50	18	model	model	NN
work_624qrp646zf4pdga57ub3qks2i	50	19	,	,	,
work_624qrp646zf4pdga57ub3qks2i	50	20	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	50	21	does	do	VBZ
work_624qrp646zf4pdga57ub3qks2i	50	22	not	not	RB
work_624qrp646zf4pdga57ub3qks2i	50	23	contribute	contribute	VB
work_624qrp646zf4pdga57ub3qks2i	50	24	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	50	25	cytokine	cytokine	NN
work_624qrp646zf4pdga57ub3qks2i	50	26	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	50	27	induced	induce	VBN
work_624qrp646zf4pdga57ub3qks2i	50	28	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	50	29	-cell	-cell	JJ
work_624qrp646zf4pdga57ub3qks2i	50	30	dam-	dam-	JJ
work_624qrp646zf4pdga57ub3qks2i	50	31	age	age	NN
work_624qrp646zf4pdga57ub3qks2i	50	32	.	.	.
work_624qrp646zf4pdga57ub3qks2i	51	1	Furthermore	furthermore	RB
work_624qrp646zf4pdga57ub3qks2i	51	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	51	3	PARP-1	parp-1	NN
work_624qrp646zf4pdga57ub3qks2i	51	4	does	do	VBZ
work_624qrp646zf4pdga57ub3qks2i	51	5	not	not	RB
work_624qrp646zf4pdga57ub3qks2i	51	6	appear	appear	VB
work_624qrp646zf4pdga57ub3qks2i	51	7	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	51	8	be	be	VB
work_624qrp646zf4pdga57ub3qks2i	51	9	implicated	implicate	VBN
work_624qrp646zf4pdga57ub3qks2i	51	10	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	51	11	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	51	12	signaling	signaling	NN
work_624qrp646zf4pdga57ub3qks2i	51	13	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	51	14	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	51	15	inflammatory	inflammatory	JJ
work_624qrp646zf4pdga57ub3qks2i	51	16	response	response	NN
work_624qrp646zf4pdga57ub3qks2i	51	17	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	51	18	macrophages	macrophage	NNS
work_624qrp646zf4pdga57ub3qks2i	51	19	.	.	.
work_624qrp646zf4pdga57ub3qks2i	52	1	These	these	DT
work_624qrp646zf4pdga57ub3qks2i	52	2	results	result	NNS
work_624qrp646zf4pdga57ub3qks2i	52	3	are	be	VBP
work_624qrp646zf4pdga57ub3qks2i	52	4	consistent	consistent	JJ
work_624qrp646zf4pdga57ub3qks2i	52	5	with	with	IN
work_624qrp646zf4pdga57ub3qks2i	52	6	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	52	7	clinical	clinical	JJ
work_624qrp646zf4pdga57ub3qks2i	52	8	trial	trial	NN
work_624qrp646zf4pdga57ub3qks2i	52	9	demonstrat-	demonstrat-	NN
work_624qrp646zf4pdga57ub3qks2i	52	10	ing	e	VBG
work_624qrp646zf4pdga57ub3qks2i	52	11	that	that	DT
work_624qrp646zf4pdga57ub3qks2i	52	12	nicotinamide	nicotinamide	NN
work_624qrp646zf4pdga57ub3qks2i	52	13	does	do	VBZ
work_624qrp646zf4pdga57ub3qks2i	52	14	not	not	RB
work_624qrp646zf4pdga57ub3qks2i	52	15	improve	improve	VB
work_624qrp646zf4pdga57ub3qks2i	52	16	onset	onset	NN
work_624qrp646zf4pdga57ub3qks2i	52	17	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	52	18	T1DM	T1DM	NNP
work_624qrp646zf4pdga57ub3qks2i	52	19	,	,	,
work_624qrp646zf4pdga57ub3qks2i	52	20	caus-	caus-	NNP
work_624qrp646zf4pdga57ub3qks2i	52	21	ing	e	VBG
work_624qrp646zf4pdga57ub3qks2i	52	22	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	52	23	serious	serious	JJ
work_624qrp646zf4pdga57ub3qks2i	52	24	“	"	``
work_624qrp646zf4pdga57ub3qks2i	52	25	nick	nick	NN
work_624qrp646zf4pdga57ub3qks2i	52	26	”	"	''
work_624qrp646zf4pdga57ub3qks2i	52	27	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	52	28	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	52	29	Okamoto	Okamoto	NNP
work_624qrp646zf4pdga57ub3qks2i	52	30	model	model	NN
work_624qrp646zf4pdga57ub3qks2i	52	31	.	.	.
work_624qrp646zf4pdga57ub3qks2i	53	1	Nonetheless	nonetheless	RB
work_624qrp646zf4pdga57ub3qks2i	53	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	53	3	one	one	CD
work_624qrp646zf4pdga57ub3qks2i	53	4	question	question	NN
work_624qrp646zf4pdga57ub3qks2i	53	5	remains	remain	VBZ
work_624qrp646zf4pdga57ub3qks2i	53	6	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	53	7	be	be	VB
work_624qrp646zf4pdga57ub3qks2i	53	8	clearly	clearly	RB
work_624qrp646zf4pdga57ub3qks2i	53	9	resolved	resolve	VBN
work_624qrp646zf4pdga57ub3qks2i	53	10	from	from	IN
work_624qrp646zf4pdga57ub3qks2i	53	11	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	53	12	study	study	NN
work_624qrp646zf4pdga57ub3qks2i	53	13	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	53	14	Andreone	Andreone	NNP
work_624qrp646zf4pdga57ub3qks2i	53	15	et	et	FW
work_624qrp646zf4pdga57ub3qks2i	53	16	al	al	NNP
work_624qrp646zf4pdga57ub3qks2i	53	17	.	.	.
work_624qrp646zf4pdga57ub3qks2i	54	1	:	:	:
work_624qrp646zf4pdga57ub3qks2i	54	2	Does	do	VBZ
work_624qrp646zf4pdga57ub3qks2i	54	3	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	54	4	deficiency	deficiency	NN
work_624qrp646zf4pdga57ub3qks2i	54	5	prevent	prevent	NN
work_624qrp646zf4pdga57ub3qks2i	54	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	54	7	beyond	beyond	IN
work_624qrp646zf4pdga57ub3qks2i	54	8	doubt	doubt	NN
work_624qrp646zf4pdga57ub3qks2i	54	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	54	10	islet	islet	NN
work_624qrp646zf4pdga57ub3qks2i	54	11	cell	cell	NN
work_624qrp646zf4pdga57ub3qks2i	54	12	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	54	13	?	?	.
work_624qrp646zf4pdga57ub3qks2i	55	1	Indeed	indeed	RB
work_624qrp646zf4pdga57ub3qks2i	55	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	55	3	DNA	dna	NN
work_624qrp646zf4pdga57ub3qks2i	55	4	damage	damage	NN
work_624qrp646zf4pdga57ub3qks2i	55	5	was	be	VBD
work_624qrp646zf4pdga57ub3qks2i	55	6	increased	increase	VBN
work_624qrp646zf4pdga57ub3qks2i	55	7	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	55	8	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	55	9	from	from	IN
work_624qrp646zf4pdga57ub3qks2i	55	10	STZ	stz	NN
work_624qrp646zf4pdga57ub3qks2i	55	11	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	55	12	treated	treat	VBN
work_624qrp646zf4pdga57ub3qks2i	55	13	PARP-1-deficient	parp-1-deficient	JJ
work_624qrp646zf4pdga57ub3qks2i	55	14	mice	mouse	NNS
work_624qrp646zf4pdga57ub3qks2i	55	15	,	,	,
work_624qrp646zf4pdga57ub3qks2i	55	16	yet	yet	CC
work_624qrp646zf4pdga57ub3qks2i	55	17	these	these	DT
work_624qrp646zf4pdga57ub3qks2i	55	18	ani-	ani-	NNS
work_624qrp646zf4pdga57ub3qks2i	55	19	mals	mal	NNS
work_624qrp646zf4pdga57ub3qks2i	55	20	did	do	VBD
work_624qrp646zf4pdga57ub3qks2i	55	21	not	not	RB
work_624qrp646zf4pdga57ub3qks2i	55	22	develop	develop	VB
work_624qrp646zf4pdga57ub3qks2i	55	23	hyperglycemia	hyperglycemia	NN
work_624qrp646zf4pdga57ub3qks2i	55	24	,	,	,
work_624qrp646zf4pdga57ub3qks2i	55	25	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	55	26	islet	islet	NN
work_624qrp646zf4pdga57ub3qks2i	55	27	integrity	integrity	NN
work_624qrp646zf4pdga57ub3qks2i	55	28	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	55	29	function	function	NN
work_624qrp646zf4pdga57ub3qks2i	55	30	were	be	VBD
work_624qrp646zf4pdga57ub3qks2i	55	31	preserved	preserve	VBN
work_624qrp646zf4pdga57ub3qks2i	55	32	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	55	33	11	11	CD
work_624qrp646zf4pdga57ub3qks2i	55	34	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	55	35	.	.	.
work_624qrp646zf4pdga57ub3qks2i	56	1	It	-PRON-	PRP
work_624qrp646zf4pdga57ub3qks2i	56	2	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	56	3	tempting	tempt	VBG
work_624qrp646zf4pdga57ub3qks2i	56	4	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	56	5	speculate	speculate	VB
work_624qrp646zf4pdga57ub3qks2i	56	6	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	56	7	PARP-2	PARP-2	NNP
work_624qrp646zf4pdga57ub3qks2i	56	8	,	,	,
work_624qrp646zf4pdga57ub3qks2i	56	9	which	which	WDT
work_624qrp646zf4pdga57ub3qks2i	56	10	accounts	account	VBZ
work_624qrp646zf4pdga57ub3qks2i	56	11	for	for	IN
work_624qrp646zf4pdga57ub3qks2i	56	12	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	56	13	10	10	CD
work_624qrp646zf4pdga57ub3qks2i	56	14	%	%	NN
work_624qrp646zf4pdga57ub3qks2i	56	15	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	56	16	all	all	DT
work_624qrp646zf4pdga57ub3qks2i	56	17	PARP	PARP	NNP
work_624qrp646zf4pdga57ub3qks2i	56	18	activity	activity	NN
work_624qrp646zf4pdga57ub3qks2i	56	19	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	56	20	mammalian	mammalian	JJ
work_624qrp646zf4pdga57ub3qks2i	56	21	cells	cell	NNS
work_624qrp646zf4pdga57ub3qks2i	56	22	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	56	23	8)	8)	CD
work_624qrp646zf4pdga57ub3qks2i	56	24	,	,	,
work_624qrp646zf4pdga57ub3qks2i	56	25	may	may	MD
work_624qrp646zf4pdga57ub3qks2i	56	26	provide	provide	VB
work_624qrp646zf4pdga57ub3qks2i	56	27	sufficient	sufficient	JJ
work_624qrp646zf4pdga57ub3qks2i	56	28	residual	residual	JJ
work_624qrp646zf4pdga57ub3qks2i	56	29	activity	activity	NN
work_624qrp646zf4pdga57ub3qks2i	56	30	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	56	31	repair	repair	VB
work_624qrp646zf4pdga57ub3qks2i	56	32	STZ	stz	NN
work_624qrp646zf4pdga57ub3qks2i	56	33	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	56	34	mediated	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	56	35	DNA	dna	NN
work_624qrp646zf4pdga57ub3qks2i	56	36	damage	damage	NN
work_624qrp646zf4pdga57ub3qks2i	56	37	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	56	38	PARP-1	parp-1	JJ
work_624qrp646zf4pdga57ub3qks2i	56	39	knockout	knockout	NN
work_624qrp646zf4pdga57ub3qks2i	56	40	mice	mouse	NNS
work_624qrp646zf4pdga57ub3qks2i	56	41	,	,	,
work_624qrp646zf4pdga57ub3qks2i	56	42	thereby	thereby	RB
work_624qrp646zf4pdga57ub3qks2i	56	43	avoiding	avoid	VBG
work_624qrp646zf4pdga57ub3qks2i	56	44	�	�	NN
work_624qrp646zf4pdga57ub3qks2i	56	45	-cell	-cell	CD
work_624qrp646zf4pdga57ub3qks2i	56	46	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	56	47	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	56	48	development	development	NN
work_624qrp646zf4pdga57ub3qks2i	56	49	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	56	50	hyperglyce-	hyperglyce-	NNP
work_624qrp646zf4pdga57ub3qks2i	56	51	mia	mia	NNP
work_624qrp646zf4pdga57ub3qks2i	56	52	.	.	.
work_624qrp646zf4pdga57ub3qks2i	57	1	In	in	IN
work_624qrp646zf4pdga57ub3qks2i	57	2	this	this	DT
work_624qrp646zf4pdga57ub3qks2i	57	3	context	context	NN
work_624qrp646zf4pdga57ub3qks2i	57	4	,	,	,
work_624qrp646zf4pdga57ub3qks2i	57	5	it	-PRON-	PRP
work_624qrp646zf4pdga57ub3qks2i	57	6	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	57	7	interesting	interesting	JJ
work_624qrp646zf4pdga57ub3qks2i	57	8	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	57	9	note	note	VB
work_624qrp646zf4pdga57ub3qks2i	57	10	that	that	IN
work_624qrp646zf4pdga57ub3qks2i	57	11	PARP-2	PARP-2	NNP
work_624qrp646zf4pdga57ub3qks2i	57	12	was	be	VBD
work_624qrp646zf4pdga57ub3qks2i	57	13	recently	recently	RB
work_624qrp646zf4pdga57ub3qks2i	57	14	shown	show	VBN
work_624qrp646zf4pdga57ub3qks2i	57	15	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	57	16	be	be	VB
work_624qrp646zf4pdga57ub3qks2i	57	17	essential	essential	JJ
work_624qrp646zf4pdga57ub3qks2i	57	18	for	for	IN
work_624qrp646zf4pdga57ub3qks2i	57	19	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	57	20	-cell	-cell	CD
work_624qrp646zf4pdga57ub3qks2i	57	21	function	function	NN
work_624qrp646zf4pdga57ub3qks2i	57	22	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	57	23	expan-	expan-	JJ
work_624qrp646zf4pdga57ub3qks2i	57	24	sion	sion	NN
work_624qrp646zf4pdga57ub3qks2i	57	25	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	57	26	response	response	NN
work_624qrp646zf4pdga57ub3qks2i	57	27	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	57	28	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	57	29	high	high	JJ
work_624qrp646zf4pdga57ub3qks2i	57	30	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	57	31	fat	fat	NN
work_624qrp646zf4pdga57ub3qks2i	57	32	diet	diet	NN
work_624qrp646zf4pdga57ub3qks2i	57	33	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	57	34	2	2	CD
work_624qrp646zf4pdga57ub3qks2i	57	35	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	57	36	.	.	.
work_624qrp646zf4pdga57ub3qks2i	58	1	Unfortunately	unfortunately	RB
work_624qrp646zf4pdga57ub3qks2i	58	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	58	3	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	58	4	long	long	JJ
work_624qrp646zf4pdga57ub3qks2i	58	5	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	58	6	term	term	NN
work_624qrp646zf4pdga57ub3qks2i	58	7	effect	effect	NN
work_624qrp646zf4pdga57ub3qks2i	58	8	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	58	9	cytokines	cytokine	NNS
work_624qrp646zf4pdga57ub3qks2i	58	10	on	on	IN
work_624qrp646zf4pdga57ub3qks2i	58	11	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	58	12	-cell	-cell	HYPH
work_624qrp646zf4pdga57ub3qks2i	58	13	DNA	dna	NN
work_624qrp646zf4pdga57ub3qks2i	58	14	damage	damage	NN
work_624qrp646zf4pdga57ub3qks2i	58	15	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	58	16	insulin	insulin	NN
work_624qrp646zf4pdga57ub3qks2i	58	17	secretion	secretion	NN
work_624qrp646zf4pdga57ub3qks2i	58	18	was	be	VBD
work_624qrp646zf4pdga57ub3qks2i	58	19	not	not	RB
work_624qrp646zf4pdga57ub3qks2i	58	20	addressed	address	VBN
work_624qrp646zf4pdga57ub3qks2i	58	21	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	58	22	Andreone	Andreone	NNP
work_624qrp646zf4pdga57ub3qks2i	58	23	et	et	FW
work_624qrp646zf4pdga57ub3qks2i	58	24	al	al	NNP
work_624qrp646zf4pdga57ub3qks2i	58	25	.	.	NNP
work_624qrp646zf4pdga57ub3qks2i	58	26	,	,	,
work_624qrp646zf4pdga57ub3qks2i	58	27	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	58	28	all	all	DT
work_624qrp646zf4pdga57ub3qks2i	58	29	experiments	experiment	NNS
work_624qrp646zf4pdga57ub3qks2i	58	30	were	be	VBD
work_624qrp646zf4pdga57ub3qks2i	58	31	performed	perform	VBN
work_624qrp646zf4pdga57ub3qks2i	58	32	within	within	IN
work_624qrp646zf4pdga57ub3qks2i	58	33	24	24	CD
work_624qrp646zf4pdga57ub3qks2i	58	34	h	h	NN
work_624qrp646zf4pdga57ub3qks2i	58	35	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	58	36	treatment	treatment	NN
work_624qrp646zf4pdga57ub3qks2i	58	37	.	.	.
work_624qrp646zf4pdga57ub3qks2i	59	1	A	a	DT
work_624qrp646zf4pdga57ub3qks2i	59	2	key	key	JJ
work_624qrp646zf4pdga57ub3qks2i	59	3	study	study	NN
work_624qrp646zf4pdga57ub3qks2i	59	4	that	that	WDT
work_624qrp646zf4pdga57ub3qks2i	59	5	could	could	MD
work_624qrp646zf4pdga57ub3qks2i	59	6	resolve	resolve	VB
work_624qrp646zf4pdga57ub3qks2i	59	7	whether	whether	IN
work_624qrp646zf4pdga57ub3qks2i	59	8	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	59	9	deficiency	deficiency	NN
work_624qrp646zf4pdga57ub3qks2i	59	10	is	be	VBZ
work_624qrp646zf4pdga57ub3qks2i	59	11	an	an	DT
work_624qrp646zf4pdga57ub3qks2i	59	12	asset	asset	NN
work_624qrp646zf4pdga57ub3qks2i	59	13	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	59	14	protecting	protect	VBG
work_624qrp646zf4pdga57ub3qks2i	59	15	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	59	16	-cells	-cells	,
work_624qrp646zf4pdga57ub3qks2i	59	17	against	against	IN
work_624qrp646zf4pdga57ub3qks2i	59	18	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	59	19	continuous	continuous	JJ
work_624qrp646zf4pdga57ub3qks2i	59	20	exposure	exposure	NN
work_624qrp646zf4pdga57ub3qks2i	59	21	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	59	22	proin-	proin-	NNP
work_624qrp646zf4pdga57ub3qks2i	59	23	flammatory	flammatory	NN
work_624qrp646zf4pdga57ub3qks2i	59	24	cytokines	cytokine	NNS
work_624qrp646zf4pdga57ub3qks2i	59	25	would	would	MD
work_624qrp646zf4pdga57ub3qks2i	59	26	involve	involve	VB
work_624qrp646zf4pdga57ub3qks2i	59	27	breeding	breeding	NN
work_624qrp646zf4pdga57ub3qks2i	59	28	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	59	29	PARP-1-	parp-1-	NN
work_624qrp646zf4pdga57ub3qks2i	59	30	deficient	deficient	JJ
work_624qrp646zf4pdga57ub3qks2i	59	31	mice	mouse	NNS
work_624qrp646zf4pdga57ub3qks2i	59	32	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	59	33	animal	animal	NN
work_624qrp646zf4pdga57ub3qks2i	59	34	models	model	NNS
work_624qrp646zf4pdga57ub3qks2i	59	35	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	59	36	experimental	experimental	JJ
work_624qrp646zf4pdga57ub3qks2i	59	37	autoimmune	autoimmune	JJ
work_624qrp646zf4pdga57ub3qks2i	59	38	diabetes	diabete	NNS
work_624qrp646zf4pdga57ub3qks2i	59	39	.	.	.
work_624qrp646zf4pdga57ub3qks2i	60	1	This	this	DT
work_624qrp646zf4pdga57ub3qks2i	60	2	approach	approach	NN
work_624qrp646zf4pdga57ub3qks2i	60	3	could	could	MD
work_624qrp646zf4pdga57ub3qks2i	60	4	also	also	RB
work_624qrp646zf4pdga57ub3qks2i	60	5	offer	offer	VB
work_624qrp646zf4pdga57ub3qks2i	60	6	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	60	7	valuable	valuable	JJ
work_624qrp646zf4pdga57ub3qks2i	60	8	tool	tool	NN
work_624qrp646zf4pdga57ub3qks2i	60	9	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	60	10	highlight	highlight	VB
work_624qrp646zf4pdga57ub3qks2i	60	11	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	60	12	resolve	resolve	VB
work_624qrp646zf4pdga57ub3qks2i	60	13	potential	potential	JJ
work_624qrp646zf4pdga57ub3qks2i	60	14	pitfalls	pitfall	NNS
work_624qrp646zf4pdga57ub3qks2i	60	15	associated	associate	VBN
work_624qrp646zf4pdga57ub3qks2i	60	16	with	with	IN
work_624qrp646zf4pdga57ub3qks2i	60	17	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	60	18	failure	failure	NN
work_624qrp646zf4pdga57ub3qks2i	60	19	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	60	20	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	60	21	inhibitors	inhibitor	NNS
work_624qrp646zf4pdga57ub3qks2i	60	22	to	to	TO
work_624qrp646zf4pdga57ub3qks2i	60	23	delay	delay	VB
work_624qrp646zf4pdga57ub3qks2i	60	24	or	or	CC
work_624qrp646zf4pdga57ub3qks2i	60	25	prevent	prevent	VB
work_624qrp646zf4pdga57ub3qks2i	60	26	onset	onset	NN
work_624qrp646zf4pdga57ub3qks2i	60	27	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	60	28	T1DM	T1DM	NNP
work_624qrp646zf4pdga57ub3qks2i	60	29	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	60	30	human	human	JJ
work_624qrp646zf4pdga57ub3qks2i	60	31	subjects	subject	NNS
work_624qrp646zf4pdga57ub3qks2i	60	32	.	.	.
work_624qrp646zf4pdga57ub3qks2i	61	1	Nonetheless	nonetheless	RB
work_624qrp646zf4pdga57ub3qks2i	61	2	,	,	,
work_624qrp646zf4pdga57ub3qks2i	61	3	recent	recent	JJ
work_624qrp646zf4pdga57ub3qks2i	61	4	findings	finding	NNS
work_624qrp646zf4pdga57ub3qks2i	61	5	dem-	dem-	RB
work_624qrp646zf4pdga57ub3qks2i	61	6	onstrating	onstrate	VBG
work_624qrp646zf4pdga57ub3qks2i	61	7	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	61	8	importance	importance	NN
work_624qrp646zf4pdga57ub3qks2i	61	9	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	61	10	PARP-2	parp-2	NN
work_624qrp646zf4pdga57ub3qks2i	61	11	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	61	12	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	61	13	-cell	-cell	CD
work_624qrp646zf4pdga57ub3qks2i	61	14	function	function	NN
work_624qrp646zf4pdga57ub3qks2i	61	15	,	,	,
work_624qrp646zf4pdga57ub3qks2i	61	16	com-	com-	NN
work_624qrp646zf4pdga57ub3qks2i	61	17	bined	bin	VBN
work_624qrp646zf4pdga57ub3qks2i	61	18	with	with	IN
work_624qrp646zf4pdga57ub3qks2i	61	19	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	61	20	apparent	apparent	JJ
work_624qrp646zf4pdga57ub3qks2i	61	21	redundancy	redundancy	NN
work_624qrp646zf4pdga57ub3qks2i	61	22	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	61	23	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	61	24	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	61	25	cytokine-	cytokine-	NNP
work_624qrp646zf4pdga57ub3qks2i	61	26	mediated	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	61	27	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	61	28	-cell	-cell	CD
work_624qrp646zf4pdga57ub3qks2i	61	29	dysfunction	dysfunction	NN
work_624qrp646zf4pdga57ub3qks2i	61	30	,	,	,
work_624qrp646zf4pdga57ub3qks2i	61	31	strongly	strongly	RB
work_624qrp646zf4pdga57ub3qks2i	61	32	argue	argue	VB
work_624qrp646zf4pdga57ub3qks2i	61	33	against	against	IN
work_624qrp646zf4pdga57ub3qks2i	61	34	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	61	35	use	use	NN
work_624qrp646zf4pdga57ub3qks2i	61	36	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	61	37	new	new	JJ
work_624qrp646zf4pdga57ub3qks2i	61	38	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	61	39	more	more	RBR
work_624qrp646zf4pdga57ub3qks2i	61	40	specific	specific	JJ
work_624qrp646zf4pdga57ub3qks2i	61	41	PARP	PARP	NNP
work_624qrp646zf4pdga57ub3qks2i	61	42	inhibitors	inhibitor	NNS
work_624qrp646zf4pdga57ub3qks2i	61	43	such	such	JJ
work_624qrp646zf4pdga57ub3qks2i	61	44	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	61	45	olaparib	olaparib	JJ
work_624qrp646zf4pdga57ub3qks2i	61	46	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	61	47	novel	novel	JJ
work_624qrp646zf4pdga57ub3qks2i	61	48	therapies	therapy	NNS
work_624qrp646zf4pdga57ub3qks2i	61	49	for	for	IN
work_624qrp646zf4pdga57ub3qks2i	61	50	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	61	51	treatment	treatment	NN
work_624qrp646zf4pdga57ub3qks2i	61	52	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	61	53	T1DM	T1DM	NNP
work_624qrp646zf4pdga57ub3qks2i	61	54	.	.	.
work_624qrp646zf4pdga57ub3qks2i	62	1	ACKNOWLEDGMENTS	acknowledgment	NNS
work_624qrp646zf4pdga57ub3qks2i	62	2	We	-PRON-	PRP
work_624qrp646zf4pdga57ub3qks2i	62	3	thank	thank	VBP
work_624qrp646zf4pdga57ub3qks2i	62	4	Dr.	Dr.	NNP
work_624qrp646zf4pdga57ub3qks2i	62	5	Felipe	Felipe	NNP
work_624qrp646zf4pdga57ub3qks2i	62	6	Cortés	Cortés	NNP
work_624qrp646zf4pdga57ub3qks2i	62	7	Ledesma	Ledesma	NNP
work_624qrp646zf4pdga57ub3qks2i	62	8	for	for	IN
work_624qrp646zf4pdga57ub3qks2i	62	9	critical	critical	JJ
work_624qrp646zf4pdga57ub3qks2i	62	10	reading	reading	NN
work_624qrp646zf4pdga57ub3qks2i	62	11	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	62	12	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	62	13	manuscript	manuscript	NN
work_624qrp646zf4pdga57ub3qks2i	62	14	.	.	.
work_624qrp646zf4pdga57ub3qks2i	63	1	GRANTS	GRANTS	NNP
work_624qrp646zf4pdga57ub3qks2i	63	2	Financial	financial	JJ
work_624qrp646zf4pdga57ub3qks2i	63	3	support	support	NN
work_624qrp646zf4pdga57ub3qks2i	63	4	for	for	IN
work_624qrp646zf4pdga57ub3qks2i	63	5	this	this	DT
work_624qrp646zf4pdga57ub3qks2i	63	6	study	study	NN
work_624qrp646zf4pdga57ub3qks2i	63	7	was	be	VBD
work_624qrp646zf4pdga57ub3qks2i	63	8	provided	provide	VBN
work_624qrp646zf4pdga57ub3qks2i	63	9	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	63	10	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	63	11	Consejeria	Consejeria	NNP
work_624qrp646zf4pdga57ub3qks2i	63	12	de	de	NNP
work_624qrp646zf4pdga57ub3qks2i	63	13	Salud	Salud	NNP
work_624qrp646zf4pdga57ub3qks2i	63	14	,	,	,
work_624qrp646zf4pdga57ub3qks2i	63	15	Junta	Junta	NNP
work_624qrp646zf4pdga57ub3qks2i	63	16	de	de	IN
work_624qrp646zf4pdga57ub3qks2i	63	17	Andalucia	Andalucia	NNP
work_624qrp646zf4pdga57ub3qks2i	63	18	,	,	,
work_624qrp646zf4pdga57ub3qks2i	63	19	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	63	20	Spanish	Spanish	NNP
work_624qrp646zf4pdga57ub3qks2i	63	21	Ministry	Ministry	NNP
work_624qrp646zf4pdga57ub3qks2i	63	22	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	63	23	Science	Science	NNP
work_624qrp646zf4pdga57ub3qks2i	63	24	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	63	25	Innovation	Innovation	NNP
work_624qrp646zf4pdga57ub3qks2i	63	26	,	,	,
work_624qrp646zf4pdga57ub3qks2i	63	27	Instituto	Instituto	NNP
work_624qrp646zf4pdga57ub3qks2i	63	28	de	de	NNP
work_624qrp646zf4pdga57ub3qks2i	63	29	Salud	Salud	NNP
work_624qrp646zf4pdga57ub3qks2i	63	30	Carlos	Carlos	NNP
work_624qrp646zf4pdga57ub3qks2i	63	31	III	III	NNP
work_624qrp646zf4pdga57ub3qks2i	63	32	,	,	,
work_624qrp646zf4pdga57ub3qks2i	63	33	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	63	34	cofunded	cofunde	VBN
work_624qrp646zf4pdga57ub3qks2i	63	35	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	63	36	Fondos	Fondos	NNP
work_624qrp646zf4pdga57ub3qks2i	63	37	FEDER	FEDER	NNP
work_624qrp646zf4pdga57ub3qks2i	63	38	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	63	39	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	63	40	Fundacion	Fundacion	NNP
work_624qrp646zf4pdga57ub3qks2i	63	41	Publica	Publica	NNP
work_624qrp646zf4pdga57ub3qks2i	63	42	Andaluza	Andaluza	NNP
work_624qrp646zf4pdga57ub3qks2i	63	43	Progreso	Progreso	NNP
work_624qrp646zf4pdga57ub3qks2i	63	44	y	y	VBZ
work_624qrp646zf4pdga57ub3qks2i	63	45	Salud	Salud	NNP
work_624qrp646zf4pdga57ub3qks2i	63	46	.	.	.
work_624qrp646zf4pdga57ub3qks2i	64	1	DISCLOSURES	DISCLOSURES	NNP
work_624qrp646zf4pdga57ub3qks2i	64	2	No	no	DT
work_624qrp646zf4pdga57ub3qks2i	64	3	conflicts	conflict	NNS
work_624qrp646zf4pdga57ub3qks2i	64	4	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	64	5	interest	interest	NN
work_624qrp646zf4pdga57ub3qks2i	64	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	64	7	financial	financial	JJ
work_624qrp646zf4pdga57ub3qks2i	64	8	or	or	CC
work_624qrp646zf4pdga57ub3qks2i	64	9	otherwise	otherwise	RB
work_624qrp646zf4pdga57ub3qks2i	64	10	,	,	,
work_624qrp646zf4pdga57ub3qks2i	64	11	are	be	VBP
work_624qrp646zf4pdga57ub3qks2i	64	12	declared	declare	VBN
work_624qrp646zf4pdga57ub3qks2i	64	13	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	64	14	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	64	15	authors	author	NNS
work_624qrp646zf4pdga57ub3qks2i	64	16	.	.	.
work_624qrp646zf4pdga57ub3qks2i	65	1	AUTHOR	AUTHOR	NNP
work_624qrp646zf4pdga57ub3qks2i	65	2	CONTRIBUTIONS	CONTRIBUTIONS	NNP
work_624qrp646zf4pdga57ub3qks2i	65	3	N.C.-V.	N.C.-V.	NNP
work_624qrp646zf4pdga57ub3qks2i	65	4	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	65	5	B.R.G.	B.R.G.	NNP
work_624qrp646zf4pdga57ub3qks2i	66	1	drafted	draft	VBD
work_624qrp646zf4pdga57ub3qks2i	66	2	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	66	3	manuscript	manuscript	NN
work_624qrp646zf4pdga57ub3qks2i	66	4	;	;	:
work_624qrp646zf4pdga57ub3qks2i	66	5	N.C.-V.	N.C.-V.	NNP
work_624qrp646zf4pdga57ub3qks2i	66	6	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	66	7	B.R.G.	B.R.G.	NNP
work_624qrp646zf4pdga57ub3qks2i	67	1	edited	edit	VBN
work_624qrp646zf4pdga57ub3qks2i	67	2	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	67	3	revised	revise	VBD
work_624qrp646zf4pdga57ub3qks2i	67	4	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	67	5	manuscript	manuscript	NN
work_624qrp646zf4pdga57ub3qks2i	67	6	;	;	:
work_624qrp646zf4pdga57ub3qks2i	67	7	N.C.-V.	N.C.-V.	NNP
work_624qrp646zf4pdga57ub3qks2i	67	8	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	67	9	B.R.G.	B.R.G.	NNP
work_624qrp646zf4pdga57ub3qks2i	68	1	approved	approve	VBD
work_624qrp646zf4pdga57ub3qks2i	68	2	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	68	3	final	final	JJ
work_624qrp646zf4pdga57ub3qks2i	68	4	version	version	NN
work_624qrp646zf4pdga57ub3qks2i	68	5	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	68	6	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	68	7	manuscript	manuscript	NN
work_624qrp646zf4pdga57ub3qks2i	68	8	.	.	.
work_624qrp646zf4pdga57ub3qks2i	69	1	REFERENCES	reference	NNS
work_624qrp646zf4pdga57ub3qks2i	69	2	1	1	CD
work_624qrp646zf4pdga57ub3qks2i	69	3	.	.	.
work_624qrp646zf4pdga57ub3qks2i	70	1	Andreone	andreone	NN
work_624qrp646zf4pdga57ub3qks2i	70	2	T	T	NNP
work_624qrp646zf4pdga57ub3qks2i	70	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	70	4	Meares	Meares	NNP
work_624qrp646zf4pdga57ub3qks2i	70	5	GP	GP	NNP
work_624qrp646zf4pdga57ub3qks2i	70	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	70	7	Hughes	Hughes	NNP
work_624qrp646zf4pdga57ub3qks2i	70	8	KJ	KJ	NNP
work_624qrp646zf4pdga57ub3qks2i	70	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	70	10	Hansen	Hansen	NNP
work_624qrp646zf4pdga57ub3qks2i	70	11	PA	PA	NNP
work_624qrp646zf4pdga57ub3qks2i	70	12	,	,	,
work_624qrp646zf4pdga57ub3qks2i	70	13	Corbett	Corbett	NNP
work_624qrp646zf4pdga57ub3qks2i	70	14	JA	JA	NNP
work_624qrp646zf4pdga57ub3qks2i	70	15	.	.	.
work_624qrp646zf4pdga57ub3qks2i	71	1	Cytokine	Cytokine	NNP
work_624qrp646zf4pdga57ub3qks2i	71	2	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	71	3	mediated	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	71	4	�	�	NN
work_624qrp646zf4pdga57ub3qks2i	71	5	-cell	-cell	HYPH
work_624qrp646zf4pdga57ub3qks2i	71	6	damage	damage	NN
work_624qrp646zf4pdga57ub3qks2i	71	7	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	71	8	PARP-1-deficient	parp-1-deficient	JJ
work_624qrp646zf4pdga57ub3qks2i	71	9	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	71	10	.	.	.
work_624qrp646zf4pdga57ub3qks2i	72	1	Am	Am	NNP
work_624qrp646zf4pdga57ub3qks2i	72	2	J	J	NNP
work_624qrp646zf4pdga57ub3qks2i	72	3	Physiol	Physiol	NNP
work_624qrp646zf4pdga57ub3qks2i	72	4	Endocrinol	Endocrinol	NNP
work_624qrp646zf4pdga57ub3qks2i	72	5	Metab	Metab	NNP
work_624qrp646zf4pdga57ub3qks2i	72	6	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	72	7	First	first	RB
work_624qrp646zf4pdga57ub3qks2i	72	8	published	publish	VBN
work_624qrp646zf4pdga57ub3qks2i	72	9	24	24	CD
work_624qrp646zf4pdga57ub3qks2i	72	10	April	April	NNP
work_624qrp646zf4pdga57ub3qks2i	72	11	2012	2012	CD
work_624qrp646zf4pdga57ub3qks2i	72	12	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	72	13	.	.	.
work_624qrp646zf4pdga57ub3qks2i	73	1	doi	doi	XX
work_624qrp646zf4pdga57ub3qks2i	73	2	:	:	:
work_624qrp646zf4pdga57ub3qks2i	73	3	10.1152	10.1152	CD
work_624qrp646zf4pdga57ub3qks2i	73	4	/	/	SYM
work_624qrp646zf4pdga57ub3qks2i	73	5	ajpendo.00055.2012	ajpendo.00055.2012	CD
work_624qrp646zf4pdga57ub3qks2i	73	6	.	.	.
work_624qrp646zf4pdga57ub3qks2i	74	1	2	2	LS
work_624qrp646zf4pdga57ub3qks2i	74	2	.	.	.
work_624qrp646zf4pdga57ub3qks2i	75	1	Bai	Bai	NNP
work_624qrp646zf4pdga57ub3qks2i	75	2	P	P	NNP
work_624qrp646zf4pdga57ub3qks2i	75	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	4	Canto	Canto	NNP
work_624qrp646zf4pdga57ub3qks2i	75	5	C	C	NNP
work_624qrp646zf4pdga57ub3qks2i	75	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	7	Brunyanszki	Brunyanszki	NNP
work_624qrp646zf4pdga57ub3qks2i	75	8	A	A	NNP
work_624qrp646zf4pdga57ub3qks2i	75	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	10	Huber	Huber	NNP
work_624qrp646zf4pdga57ub3qks2i	75	11	A	A	NNP
work_624qrp646zf4pdga57ub3qks2i	75	12	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	13	Szanto	Szanto	NNP
work_624qrp646zf4pdga57ub3qks2i	75	14	M	M	NNP
work_624qrp646zf4pdga57ub3qks2i	75	15	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	16	Cen	Cen	NNP
work_624qrp646zf4pdga57ub3qks2i	75	17	Y	Y	NNP
work_624qrp646zf4pdga57ub3qks2i	75	18	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	19	Yamamoto	Yamamoto	NNP
work_624qrp646zf4pdga57ub3qks2i	75	20	H	H	NNP
work_624qrp646zf4pdga57ub3qks2i	75	21	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	22	Houten	Houten	NNP
work_624qrp646zf4pdga57ub3qks2i	75	23	SM	SM	NNP
work_624qrp646zf4pdga57ub3qks2i	75	24	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	25	Kiss	Kiss	NNP
work_624qrp646zf4pdga57ub3qks2i	75	26	B	B	NNP
work_624qrp646zf4pdga57ub3qks2i	75	27	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	28	Oudart	Oudart	NNP
work_624qrp646zf4pdga57ub3qks2i	75	29	H	H	NNP
work_624qrp646zf4pdga57ub3qks2i	75	30	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	31	Gergely	gergely	RB
work_624qrp646zf4pdga57ub3qks2i	75	32	P	p	NN
work_624qrp646zf4pdga57ub3qks2i	75	33	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	34	Menissier	Menissier	NNP
work_624qrp646zf4pdga57ub3qks2i	75	35	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	75	36	de	de	NNP
work_624qrp646zf4pdga57ub3qks2i	75	37	Murcia	Murcia	NNP
work_624qrp646zf4pdga57ub3qks2i	75	38	J	J	NNP
work_624qrp646zf4pdga57ub3qks2i	75	39	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	40	Schreiber	Schreiber	NNP
work_624qrp646zf4pdga57ub3qks2i	75	41	V	V	NNP
work_624qrp646zf4pdga57ub3qks2i	75	42	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	43	Sauve	Sauve	NNP
work_624qrp646zf4pdga57ub3qks2i	75	44	AA	AA	NNP
work_624qrp646zf4pdga57ub3qks2i	75	45	,	,	,
work_624qrp646zf4pdga57ub3qks2i	75	46	Auwerx	Auwerx	NNP
work_624qrp646zf4pdga57ub3qks2i	75	47	J.	J.	NNP
work_624qrp646zf4pdga57ub3qks2i	75	48	PARP-2	PARP-2	NNP
work_624qrp646zf4pdga57ub3qks2i	75	49	regulates	regulate	VBZ
work_624qrp646zf4pdga57ub3qks2i	75	50	SIRT1	sirt1	IN
work_624qrp646zf4pdga57ub3qks2i	75	51	expression	expression	NN
work_624qrp646zf4pdga57ub3qks2i	75	52	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	75	53	whole	whole	JJ
work_624qrp646zf4pdga57ub3qks2i	75	54	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	75	55	body	body	NN
work_624qrp646zf4pdga57ub3qks2i	75	56	energy	energy	NN
work_624qrp646zf4pdga57ub3qks2i	75	57	expenditure	expenditure	NN
work_624qrp646zf4pdga57ub3qks2i	75	58	.	.	.
work_624qrp646zf4pdga57ub3qks2i	76	1	Cell	Cell	NNP
work_624qrp646zf4pdga57ub3qks2i	76	2	Metab	Metab	NNP
work_624qrp646zf4pdga57ub3qks2i	76	3	13	13	CD
work_624qrp646zf4pdga57ub3qks2i	76	4	:	:	:
work_624qrp646zf4pdga57ub3qks2i	76	5	450	450	CD
work_624qrp646zf4pdga57ub3qks2i	76	6	–	–	:
work_624qrp646zf4pdga57ub3qks2i	76	7	460	460	CD
work_624qrp646zf4pdga57ub3qks2i	76	8	,	,	,
work_624qrp646zf4pdga57ub3qks2i	76	9	2011	2011	CD
work_624qrp646zf4pdga57ub3qks2i	76	10	.	.	.
work_624qrp646zf4pdga57ub3qks2i	77	1	3	3	LS
work_624qrp646zf4pdga57ub3qks2i	77	2	.	.	.
work_624qrp646zf4pdga57ub3qks2i	78	1	Burkart	Burkart	NNP
work_624qrp646zf4pdga57ub3qks2i	78	2	V	V	NNP
work_624qrp646zf4pdga57ub3qks2i	78	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	78	4	Wang	Wang	NNP
work_624qrp646zf4pdga57ub3qks2i	78	5	ZQ	ZQ	NNP
work_624qrp646zf4pdga57ub3qks2i	78	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	78	7	Radons	Radons	NNP
work_624qrp646zf4pdga57ub3qks2i	78	8	J	J	NNP
work_624qrp646zf4pdga57ub3qks2i	78	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	78	10	Heller	Heller	NNP
work_624qrp646zf4pdga57ub3qks2i	78	11	B	B	NNP
work_624qrp646zf4pdga57ub3qks2i	78	12	,	,	,
work_624qrp646zf4pdga57ub3qks2i	78	13	Herceg	Herceg	NNP
work_624qrp646zf4pdga57ub3qks2i	78	14	Z	Z	NNP
work_624qrp646zf4pdga57ub3qks2i	78	15	,	,	,
work_624qrp646zf4pdga57ub3qks2i	78	16	Stingl	Stingl	NNP
work_624qrp646zf4pdga57ub3qks2i	78	17	L	L	NNP
work_624qrp646zf4pdga57ub3qks2i	78	18	,	,	,
work_624qrp646zf4pdga57ub3qks2i	78	19	Wagner	Wagner	NNP
work_624qrp646zf4pdga57ub3qks2i	78	20	EF	EF	NNP
work_624qrp646zf4pdga57ub3qks2i	78	21	,	,	,
work_624qrp646zf4pdga57ub3qks2i	78	22	Kolb	Kolb	NNP
work_624qrp646zf4pdga57ub3qks2i	78	23	H.	H.	NNP
work_624qrp646zf4pdga57ub3qks2i	78	24	Mice	Mice	NNP
work_624qrp646zf4pdga57ub3qks2i	78	25	lacking	lack	VBG
work_624qrp646zf4pdga57ub3qks2i	78	26	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	78	27	poly(ADP	poly(adp	NN
work_624qrp646zf4pdga57ub3qks2i	78	28	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	78	29	ribose	ribose	NN
work_624qrp646zf4pdga57ub3qks2i	78	30	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	78	31	polymerase	polymerase	NN
work_624qrp646zf4pdga57ub3qks2i	78	32	gene	gene	NN
work_624qrp646zf4pdga57ub3qks2i	78	33	are	be	VBP
work_624qrp646zf4pdga57ub3qks2i	78	34	resistant	resistant	JJ
work_624qrp646zf4pdga57ub3qks2i	78	35	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	78	36	pancreatic	pancreatic	JJ
work_624qrp646zf4pdga57ub3qks2i	78	37	beta	beta	JJ
work_624qrp646zf4pdga57ub3qks2i	78	38	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	78	39	cell	cell	NN
work_624qrp646zf4pdga57ub3qks2i	78	40	destruction	destruction	NN
work_624qrp646zf4pdga57ub3qks2i	78	41	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	78	42	diabetes	diabetes	NN
work_624qrp646zf4pdga57ub3qks2i	78	43	development	development	NN
work_624qrp646zf4pdga57ub3qks2i	78	44	induced	induce	VBN
work_624qrp646zf4pdga57ub3qks2i	78	45	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	78	46	streptozocin	streptozocin	NN
work_624qrp646zf4pdga57ub3qks2i	78	47	.	.	.
work_624qrp646zf4pdga57ub3qks2i	79	1	Nat	Nat	NNP
work_624qrp646zf4pdga57ub3qks2i	79	2	Med	Med	NNP
work_624qrp646zf4pdga57ub3qks2i	79	3	5	5	CD
work_624qrp646zf4pdga57ub3qks2i	79	4	:	:	:
work_624qrp646zf4pdga57ub3qks2i	79	5	314	314	CD
work_624qrp646zf4pdga57ub3qks2i	79	6	–	–	:
work_624qrp646zf4pdga57ub3qks2i	79	7	319	319	CD
work_624qrp646zf4pdga57ub3qks2i	79	8	,	,	,
work_624qrp646zf4pdga57ub3qks2i	79	9	1999	1999	CD
work_624qrp646zf4pdga57ub3qks2i	79	10	.	.	.
work_624qrp646zf4pdga57ub3qks2i	80	1	4	4	LS
work_624qrp646zf4pdga57ub3qks2i	80	2	.	.	.
work_624qrp646zf4pdga57ub3qks2i	81	1	Eizirik	Eizirik	NNP
work_624qrp646zf4pdga57ub3qks2i	81	2	DL	DL	NNP
work_624qrp646zf4pdga57ub3qks2i	81	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	81	4	Mandrup	Mandrup	NNP
work_624qrp646zf4pdga57ub3qks2i	81	5	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	81	6	Poulsen	Poulsen	NNP
work_624qrp646zf4pdga57ub3qks2i	81	7	T.	T.	NNP
work_624qrp646zf4pdga57ub3qks2i	81	8	A	a	DT
work_624qrp646zf4pdga57ub3qks2i	81	9	choice	choice	NN
work_624qrp646zf4pdga57ub3qks2i	81	10	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	81	11	death	death	NN
work_624qrp646zf4pdga57ub3qks2i	81	12	—	—	:
work_624qrp646zf4pdga57ub3qks2i	81	13	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	81	14	signal	signal	NN
work_624qrp646zf4pdga57ub3qks2i	81	15	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	81	16	trans-	trans-	NN
work_624qrp646zf4pdga57ub3qks2i	81	17	duction	duction	NN
work_624qrp646zf4pdga57ub3qks2i	81	18	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	81	19	immune	immune	NN
work_624qrp646zf4pdga57ub3qks2i	81	20	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	81	21	mediated	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	81	22	beta	beta	NN
work_624qrp646zf4pdga57ub3qks2i	81	23	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	81	24	cell	cell	NN
work_624qrp646zf4pdga57ub3qks2i	81	25	apoptosis	apoptosis	NN
work_624qrp646zf4pdga57ub3qks2i	81	26	.	.	.
work_624qrp646zf4pdga57ub3qks2i	82	1	Diabetologia	Diabetologia	NNP
work_624qrp646zf4pdga57ub3qks2i	82	2	44	44	CD
work_624qrp646zf4pdga57ub3qks2i	82	3	:	:	:
work_624qrp646zf4pdga57ub3qks2i	82	4	2115	2115	CD
work_624qrp646zf4pdga57ub3qks2i	82	5	–	–	:
work_624qrp646zf4pdga57ub3qks2i	82	6	2133	2133	CD
work_624qrp646zf4pdga57ub3qks2i	82	7	,	,	,
work_624qrp646zf4pdga57ub3qks2i	82	8	2001	2001	CD
work_624qrp646zf4pdga57ub3qks2i	82	9	.	.	.
work_624qrp646zf4pdga57ub3qks2i	83	1	5	5	CD
work_624qrp646zf4pdga57ub3qks2i	83	2	.	.	.
work_624qrp646zf4pdga57ub3qks2i	84	1	Gale	Gale	NNP
work_624qrp646zf4pdga57ub3qks2i	84	2	EA	EA	NNP
work_624qrp646zf4pdga57ub3qks2i	84	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	84	4	Bingley	Bingley	NNP
work_624qrp646zf4pdga57ub3qks2i	84	5	PJ	PJ	NNP
work_624qrp646zf4pdga57ub3qks2i	84	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	84	7	Emmett	Emmett	NNP
work_624qrp646zf4pdga57ub3qks2i	84	8	CL	CL	NNP
work_624qrp646zf4pdga57ub3qks2i	84	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	84	10	Collier	Collier	NNP
work_624qrp646zf4pdga57ub3qks2i	84	11	T.	T.	NNP
work_624qrp646zf4pdga57ub3qks2i	84	12	European	European	NNP
work_624qrp646zf4pdga57ub3qks2i	84	13	Nicotinamide	Nicotinamide	NNP
work_624qrp646zf4pdga57ub3qks2i	84	14	Diabetes	Diabetes	NNP
work_624qrp646zf4pdga57ub3qks2i	84	15	Intervention	Intervention	NNP
work_624qrp646zf4pdga57ub3qks2i	84	16	Trial	Trial	NNP
work_624qrp646zf4pdga57ub3qks2i	84	17	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	84	18	ENDIT	ENDIT	NNP
work_624qrp646zf4pdga57ub3qks2i	84	19	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	84	20	:	:	:
work_624qrp646zf4pdga57ub3qks2i	84	21	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	84	22	randomised	randomised	JJ
work_624qrp646zf4pdga57ub3qks2i	84	23	controlled	controlled	JJ
work_624qrp646zf4pdga57ub3qks2i	84	24	trial	trial	NN
work_624qrp646zf4pdga57ub3qks2i	84	25	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	84	26	intervention	intervention	NN
work_624qrp646zf4pdga57ub3qks2i	84	27	before	before	IN
work_624qrp646zf4pdga57ub3qks2i	84	28	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	84	29	onset	onset	NN
work_624qrp646zf4pdga57ub3qks2i	84	30	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	84	31	type	type	NN
work_624qrp646zf4pdga57ub3qks2i	84	32	1	1	CD
work_624qrp646zf4pdga57ub3qks2i	84	33	diabetes	diabetes	NN
work_624qrp646zf4pdga57ub3qks2i	84	34	.	.	.
work_624qrp646zf4pdga57ub3qks2i	85	1	Lancet	Lancet	NNP
work_624qrp646zf4pdga57ub3qks2i	85	2	363	363	CD
work_624qrp646zf4pdga57ub3qks2i	85	3	:	:	:
work_624qrp646zf4pdga57ub3qks2i	85	4	925–931	925–931	CD
work_624qrp646zf4pdga57ub3qks2i	85	5	,	,	,
work_624qrp646zf4pdga57ub3qks2i	85	6	2004	2004	CD
work_624qrp646zf4pdga57ub3qks2i	85	7	.	.	.
work_624qrp646zf4pdga57ub3qks2i	86	1	6	6	CD
work_624qrp646zf4pdga57ub3qks2i	86	2	.	.	.
work_624qrp646zf4pdga57ub3qks2i	87	1	Heller	Heller	NNP
work_624qrp646zf4pdga57ub3qks2i	87	2	B	B	NNP
work_624qrp646zf4pdga57ub3qks2i	87	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	87	4	Wang	Wang	NNP
work_624qrp646zf4pdga57ub3qks2i	87	5	ZQ	ZQ	NNP
work_624qrp646zf4pdga57ub3qks2i	87	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	87	7	Wagner	Wagner	NNP
work_624qrp646zf4pdga57ub3qks2i	87	8	EF	EF	NNP
work_624qrp646zf4pdga57ub3qks2i	87	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	87	10	Radons	Radons	NNP
work_624qrp646zf4pdga57ub3qks2i	87	11	J	J	NNP
work_624qrp646zf4pdga57ub3qks2i	87	12	,	,	,
work_624qrp646zf4pdga57ub3qks2i	87	13	Burkle	Burkle	NNP
work_624qrp646zf4pdga57ub3qks2i	87	14	A	A	NNP
work_624qrp646zf4pdga57ub3qks2i	87	15	,	,	,
work_624qrp646zf4pdga57ub3qks2i	87	16	Fehsel	Fehsel	NNP
work_624qrp646zf4pdga57ub3qks2i	87	17	K	K	NNP
work_624qrp646zf4pdga57ub3qks2i	87	18	,	,	,
work_624qrp646zf4pdga57ub3qks2i	87	19	Burkart	Burkart	NNP
work_624qrp646zf4pdga57ub3qks2i	87	20	V	V	NNP
work_624qrp646zf4pdga57ub3qks2i	87	21	,	,	,
work_624qrp646zf4pdga57ub3qks2i	87	22	Kolb	Kolb	NNP
work_624qrp646zf4pdga57ub3qks2i	87	23	H.	H.	NNP
work_624qrp646zf4pdga57ub3qks2i	87	24	Inactivation	Inactivation	NNP
work_624qrp646zf4pdga57ub3qks2i	87	25	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	87	26	the	the	DT
work_624qrp646zf4pdga57ub3qks2i	87	27	poly(ADP	poly(adp	NN
work_624qrp646zf4pdga57ub3qks2i	87	28	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	87	29	ribose	ribose	NN
work_624qrp646zf4pdga57ub3qks2i	87	30	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	87	31	polymerase	polymerase	NN
work_624qrp646zf4pdga57ub3qks2i	87	32	gene	gene	NN
work_624qrp646zf4pdga57ub3qks2i	87	33	affects	affect	VBZ
work_624qrp646zf4pdga57ub3qks2i	87	34	oxygen	oxygen	NN
work_624qrp646zf4pdga57ub3qks2i	87	35	radical	radical	JJ
work_624qrp646zf4pdga57ub3qks2i	87	36	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	87	37	nitric	nitric	JJ
work_624qrp646zf4pdga57ub3qks2i	87	38	oxide	oxide	NN
work_624qrp646zf4pdga57ub3qks2i	87	39	toxicity	toxicity	NN
work_624qrp646zf4pdga57ub3qks2i	87	40	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	87	41	islet	islet	NN
work_624qrp646zf4pdga57ub3qks2i	87	42	cells	cell	NNS
work_624qrp646zf4pdga57ub3qks2i	87	43	.	.	.
work_624qrp646zf4pdga57ub3qks2i	88	1	J	J	NNP
work_624qrp646zf4pdga57ub3qks2i	88	2	Biol	Biol	NNP
work_624qrp646zf4pdga57ub3qks2i	88	3	Chem	Chem	NNP
work_624qrp646zf4pdga57ub3qks2i	88	4	270	270	CD
work_624qrp646zf4pdga57ub3qks2i	88	5	:	:	:
work_624qrp646zf4pdga57ub3qks2i	88	6	11176	11176	CD
work_624qrp646zf4pdga57ub3qks2i	88	7	–	–	:
work_624qrp646zf4pdga57ub3qks2i	88	8	11180	11180	CD
work_624qrp646zf4pdga57ub3qks2i	88	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	88	10	1995	1995	CD
work_624qrp646zf4pdga57ub3qks2i	88	11	.	.	.
work_624qrp646zf4pdga57ub3qks2i	89	1	7	7	LS
work_624qrp646zf4pdga57ub3qks2i	89	2	.	.	.
work_624qrp646zf4pdga57ub3qks2i	90	1	Lenzen	Lenzen	NNP
work_624qrp646zf4pdga57ub3qks2i	90	2	S.	S.	NNP
work_624qrp646zf4pdga57ub3qks2i	90	3	The	the	DT
work_624qrp646zf4pdga57ub3qks2i	90	4	mechanisms	mechanism	NNS
work_624qrp646zf4pdga57ub3qks2i	90	5	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	90	6	alloxan-	alloxan-	NN
work_624qrp646zf4pdga57ub3qks2i	90	7	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	90	8	streptozotocin	streptozotocin	NN
work_624qrp646zf4pdga57ub3qks2i	90	9	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	90	10	induced	induce	VBN
work_624qrp646zf4pdga57ub3qks2i	90	11	dia-	dia-	NNP
work_624qrp646zf4pdga57ub3qks2i	90	12	betes	bete	NNS
work_624qrp646zf4pdga57ub3qks2i	90	13	.	.	.
work_624qrp646zf4pdga57ub3qks2i	91	1	Diabetologia	Diabetologia	NNP
work_624qrp646zf4pdga57ub3qks2i	91	2	51	51	CD
work_624qrp646zf4pdga57ub3qks2i	91	3	:	:	:
work_624qrp646zf4pdga57ub3qks2i	91	4	216	216	CD
work_624qrp646zf4pdga57ub3qks2i	91	5	–	–	:
work_624qrp646zf4pdga57ub3qks2i	91	6	226	226	CD
work_624qrp646zf4pdga57ub3qks2i	91	7	,	,	,
work_624qrp646zf4pdga57ub3qks2i	91	8	2008	2008	CD
work_624qrp646zf4pdga57ub3qks2i	91	9	.	.	.
work_624qrp646zf4pdga57ub3qks2i	92	1	8	8	LS
work_624qrp646zf4pdga57ub3qks2i	92	2	.	.	.
work_624qrp646zf4pdga57ub3qks2i	93	1	Luo	Luo	NNP
work_624qrp646zf4pdga57ub3qks2i	93	2	X	X	NNP
work_624qrp646zf4pdga57ub3qks2i	93	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	93	4	Kraus	Kraus	NNP
work_624qrp646zf4pdga57ub3qks2i	93	5	WL	WL	NNP
work_624qrp646zf4pdga57ub3qks2i	93	6	.	.	.
work_624qrp646zf4pdga57ub3qks2i	94	1	On	on	IN
work_624qrp646zf4pdga57ub3qks2i	94	2	PAR	PAR	NNP
work_624qrp646zf4pdga57ub3qks2i	94	3	with	with	IN
work_624qrp646zf4pdga57ub3qks2i	94	4	PARP	PARP	NNP
work_624qrp646zf4pdga57ub3qks2i	94	5	:	:	:
work_624qrp646zf4pdga57ub3qks2i	94	6	cellular	cellular	JJ
work_624qrp646zf4pdga57ub3qks2i	94	7	stress	stress	NN
work_624qrp646zf4pdga57ub3qks2i	94	8	signaling	signal	VBG
work_624qrp646zf4pdga57ub3qks2i	94	9	through	through	IN
work_624qrp646zf4pdga57ub3qks2i	94	10	poly(ADP	poly(ADP	NNP
work_624qrp646zf4pdga57ub3qks2i	94	11	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	94	12	ribose	ribose	NN
work_624qrp646zf4pdga57ub3qks2i	94	13	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	94	14	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	94	15	PARP-1	PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	94	16	.	.	.
work_624qrp646zf4pdga57ub3qks2i	95	1	Genes	Genes	NNP
work_624qrp646zf4pdga57ub3qks2i	95	2	Dev	Dev	NNP
work_624qrp646zf4pdga57ub3qks2i	95	3	26	26	CD
work_624qrp646zf4pdga57ub3qks2i	95	4	:	:	:
work_624qrp646zf4pdga57ub3qks2i	95	5	417–432	417–432	CD
work_624qrp646zf4pdga57ub3qks2i	95	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	95	7	2012	2012	CD
work_624qrp646zf4pdga57ub3qks2i	95	8	.	.	.
work_624qrp646zf4pdga57ub3qks2i	96	1	9	9	CD
work_624qrp646zf4pdga57ub3qks2i	96	2	.	.	.
work_624qrp646zf4pdga57ub3qks2i	97	1	Masutani	Masutani	NNP
work_624qrp646zf4pdga57ub3qks2i	97	2	M	M	NNP
work_624qrp646zf4pdga57ub3qks2i	97	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	97	4	Suzuki	Suzuki	NNP
work_624qrp646zf4pdga57ub3qks2i	97	5	H	H	NNP
work_624qrp646zf4pdga57ub3qks2i	97	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	97	7	Kamada	Kamada	NNP
work_624qrp646zf4pdga57ub3qks2i	97	8	N	N	NNP
work_624qrp646zf4pdga57ub3qks2i	97	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	97	10	Watanabe	Watanabe	NNP
work_624qrp646zf4pdga57ub3qks2i	97	11	M	M	NNP
work_624qrp646zf4pdga57ub3qks2i	97	12	,	,	,
work_624qrp646zf4pdga57ub3qks2i	97	13	Ueda	Ueda	NNP
work_624qrp646zf4pdga57ub3qks2i	97	14	O	O	NNP
work_624qrp646zf4pdga57ub3qks2i	97	15	,	,	,
work_624qrp646zf4pdga57ub3qks2i	97	16	Nozaki	Nozaki	NNP
work_624qrp646zf4pdga57ub3qks2i	97	17	T	T	NNP
work_624qrp646zf4pdga57ub3qks2i	97	18	,	,	,
work_624qrp646zf4pdga57ub3qks2i	97	19	Jishage	Jishage	NNP
work_624qrp646zf4pdga57ub3qks2i	97	20	K	K	NNP
work_624qrp646zf4pdga57ub3qks2i	97	21	,	,	,
work_624qrp646zf4pdga57ub3qks2i	97	22	Watanabe	Watanabe	NNP
work_624qrp646zf4pdga57ub3qks2i	97	23	T	T	NNP
work_624qrp646zf4pdga57ub3qks2i	97	24	,	,	,
work_624qrp646zf4pdga57ub3qks2i	97	25	Sugimoto	Sugimoto	NNP
work_624qrp646zf4pdga57ub3qks2i	97	26	T	T	NNP
work_624qrp646zf4pdga57ub3qks2i	97	27	,	,	,
work_624qrp646zf4pdga57ub3qks2i	97	28	Nakagama	Nakagama	NNP
work_624qrp646zf4pdga57ub3qks2i	97	29	H	H	NNP
work_624qrp646zf4pdga57ub3qks2i	97	30	,	,	,
work_624qrp646zf4pdga57ub3qks2i	97	31	Ochiya	Ochiya	NNP
work_624qrp646zf4pdga57ub3qks2i	97	32	T	T	NNP
work_624qrp646zf4pdga57ub3qks2i	97	33	,	,	,
work_624qrp646zf4pdga57ub3qks2i	97	34	Sug-	Sug-	NNP
work_624qrp646zf4pdga57ub3qks2i	97	35	imura	imura	NNP
work_624qrp646zf4pdga57ub3qks2i	97	36	T.	T.	NNP
work_624qrp646zf4pdga57ub3qks2i	97	37	Poly(ADP	poly(adp	NN
work_624qrp646zf4pdga57ub3qks2i	97	38	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	97	39	ribose	ribose	NN
work_624qrp646zf4pdga57ub3qks2i	97	40	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	97	41	polymerase	polymerase	NN
work_624qrp646zf4pdga57ub3qks2i	97	42	gene	gene	NN
work_624qrp646zf4pdga57ub3qks2i	97	43	disruption	disruption	NNP
work_624qrp646zf4pdga57ub3qks2i	97	44	conferred	confer	VBN
work_624qrp646zf4pdga57ub3qks2i	97	45	mice	mouse	NNS
work_624qrp646zf4pdga57ub3qks2i	97	46	resistant	resistant	JJ
work_624qrp646zf4pdga57ub3qks2i	97	47	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	97	48	streptozotocin	streptozotocin	NN
work_624qrp646zf4pdga57ub3qks2i	97	49	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	97	50	induced	induce	VBN
work_624qrp646zf4pdga57ub3qks2i	97	51	diabetes	diabete	NNS
work_624qrp646zf4pdga57ub3qks2i	97	52	.	.	.
work_624qrp646zf4pdga57ub3qks2i	98	1	Proc	Proc	NNP
work_624qrp646zf4pdga57ub3qks2i	98	2	Natl	Natl	NNP
work_624qrp646zf4pdga57ub3qks2i	98	3	Acad	Acad	NNP
work_624qrp646zf4pdga57ub3qks2i	98	4	Sci	Sci	NNP
work_624qrp646zf4pdga57ub3qks2i	98	5	USA	USA	NNP
work_624qrp646zf4pdga57ub3qks2i	98	6	96	96	CD
work_624qrp646zf4pdga57ub3qks2i	98	7	:	:	:
work_624qrp646zf4pdga57ub3qks2i	98	8	2301–2304	2301–2304	CD
work_624qrp646zf4pdga57ub3qks2i	98	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	98	10	1999	1999	CD
work_624qrp646zf4pdga57ub3qks2i	98	11	.	.	.
work_624qrp646zf4pdga57ub3qks2i	99	1	10	10	CD
work_624qrp646zf4pdga57ub3qks2i	99	2	.	.	.
work_624qrp646zf4pdga57ub3qks2i	100	1	Oliver	Oliver	NNP
work_624qrp646zf4pdga57ub3qks2i	100	2	FJ	FJ	NNP
work_624qrp646zf4pdga57ub3qks2i	100	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	100	4	Menissier	Menissier	NNP
work_624qrp646zf4pdga57ub3qks2i	100	5	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	100	6	de	de	NNP
work_624qrp646zf4pdga57ub3qks2i	100	7	Murcia	Murcia	NNP
work_624qrp646zf4pdga57ub3qks2i	100	8	J	J	NNP
work_624qrp646zf4pdga57ub3qks2i	100	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	100	10	Nacci	Nacci	NNP
work_624qrp646zf4pdga57ub3qks2i	100	11	C	C	NNP
work_624qrp646zf4pdga57ub3qks2i	100	12	,	,	,
work_624qrp646zf4pdga57ub3qks2i	100	13	Decker	Decker	NNP
work_624qrp646zf4pdga57ub3qks2i	100	14	P	P	NNP
work_624qrp646zf4pdga57ub3qks2i	100	15	,	,	,
work_624qrp646zf4pdga57ub3qks2i	100	16	Andriantsito-	Andriantsito-	NNP
work_624qrp646zf4pdga57ub3qks2i	100	17	haina	haina	NN
work_624qrp646zf4pdga57ub3qks2i	100	18	R	r	NN
work_624qrp646zf4pdga57ub3qks2i	100	19	,	,	,
work_624qrp646zf4pdga57ub3qks2i	100	20	Muller	Muller	NNP
work_624qrp646zf4pdga57ub3qks2i	100	21	S	S	NNP
work_624qrp646zf4pdga57ub3qks2i	100	22	,	,	,
work_624qrp646zf4pdga57ub3qks2i	100	23	de	de	NNP
work_624qrp646zf4pdga57ub3qks2i	100	24	la	la	NNP
work_624qrp646zf4pdga57ub3qks2i	100	25	Rubia	Rubia	NNP
work_624qrp646zf4pdga57ub3qks2i	100	26	G	G	NNP
work_624qrp646zf4pdga57ub3qks2i	100	27	,	,	,
work_624qrp646zf4pdga57ub3qks2i	100	28	Stoclet	Stoclet	NNP
work_624qrp646zf4pdga57ub3qks2i	100	29	JC	JC	NNP
work_624qrp646zf4pdga57ub3qks2i	100	30	,	,	,
work_624qrp646zf4pdga57ub3qks2i	100	31	de	de	NNP
work_624qrp646zf4pdga57ub3qks2i	100	32	Murcia	Murcia	NNP
work_624qrp646zf4pdga57ub3qks2i	100	33	G.	G.	NNP
work_624qrp646zf4pdga57ub3qks2i	100	34	Resistance	Resistance	NNP
work_624qrp646zf4pdga57ub3qks2i	100	35	to	to	IN
work_624qrp646zf4pdga57ub3qks2i	100	36	endotoxic	endotoxic	JJ
work_624qrp646zf4pdga57ub3qks2i	100	37	shock	shock	NN
work_624qrp646zf4pdga57ub3qks2i	100	38	as	as	IN
work_624qrp646zf4pdga57ub3qks2i	100	39	a	a	DT
work_624qrp646zf4pdga57ub3qks2i	100	40	consequence	consequence	NN
work_624qrp646zf4pdga57ub3qks2i	100	41	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	100	42	defective	defective	JJ
work_624qrp646zf4pdga57ub3qks2i	100	43	NF-	NF-	NNP
work_624qrp646zf4pdga57ub3qks2i	100	44	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	100	45	B	b	NN
work_624qrp646zf4pdga57ub3qks2i	100	46	activation	activation	NN
work_624qrp646zf4pdga57ub3qks2i	100	47	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	100	48	poly(ADP	poly(ADP	NNP
work_624qrp646zf4pdga57ub3qks2i	100	49	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	100	50	ribose	ribose	NN
work_624qrp646zf4pdga57ub3qks2i	100	51	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	100	52	polymerase-1	polymerase-1	VB
work_624qrp646zf4pdga57ub3qks2i	100	53	deficient	deficient	JJ
work_624qrp646zf4pdga57ub3qks2i	100	54	mice	mouse	NNS
work_624qrp646zf4pdga57ub3qks2i	100	55	.	.	.
work_624qrp646zf4pdga57ub3qks2i	101	1	EMBO	EMBO	NNP
work_624qrp646zf4pdga57ub3qks2i	101	2	J	J	NNP
work_624qrp646zf4pdga57ub3qks2i	101	3	18	18	CD
work_624qrp646zf4pdga57ub3qks2i	101	4	:	:	SYM
work_624qrp646zf4pdga57ub3qks2i	101	5	4446	4446	CD
work_624qrp646zf4pdga57ub3qks2i	101	6	–	–	:
work_624qrp646zf4pdga57ub3qks2i	101	7	4454	4454	CD
work_624qrp646zf4pdga57ub3qks2i	101	8	,	,	,
work_624qrp646zf4pdga57ub3qks2i	101	9	1999	1999	CD
work_624qrp646zf4pdga57ub3qks2i	101	10	.	.	.
work_624qrp646zf4pdga57ub3qks2i	102	1	11	11	CD
work_624qrp646zf4pdga57ub3qks2i	102	2	.	.	.
work_624qrp646zf4pdga57ub3qks2i	103	1	Pieper	pieper	NN
work_624qrp646zf4pdga57ub3qks2i	103	2	AA	AA	NNS
work_624qrp646zf4pdga57ub3qks2i	103	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	103	4	Brat	Brat	NNP
work_624qrp646zf4pdga57ub3qks2i	103	5	DJ	DJ	NNP
work_624qrp646zf4pdga57ub3qks2i	103	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	103	7	Krug	Krug	NNP
work_624qrp646zf4pdga57ub3qks2i	103	8	DK	DK	NNP
work_624qrp646zf4pdga57ub3qks2i	103	9	,	,	,
work_624qrp646zf4pdga57ub3qks2i	103	10	Watkins	Watkins	NNP
work_624qrp646zf4pdga57ub3qks2i	103	11	CC	CC	NNP
work_624qrp646zf4pdga57ub3qks2i	103	12	,	,	,
work_624qrp646zf4pdga57ub3qks2i	103	13	Gupta	Gupta	NNP
work_624qrp646zf4pdga57ub3qks2i	103	14	A	A	NNP
work_624qrp646zf4pdga57ub3qks2i	103	15	,	,	,
work_624qrp646zf4pdga57ub3qks2i	103	16	Blackshaw	Blackshaw	NNP
work_624qrp646zf4pdga57ub3qks2i	103	17	S	S	NNP
work_624qrp646zf4pdga57ub3qks2i	103	18	,	,	,
work_624qrp646zf4pdga57ub3qks2i	103	19	Verma	Verma	NNP
work_624qrp646zf4pdga57ub3qks2i	103	20	A	A	NNP
work_624qrp646zf4pdga57ub3qks2i	103	21	,	,	,
work_624qrp646zf4pdga57ub3qks2i	103	22	Wang	Wang	NNP
work_624qrp646zf4pdga57ub3qks2i	103	23	ZQ	ZQ	NNP
work_624qrp646zf4pdga57ub3qks2i	103	24	,	,	,
work_624qrp646zf4pdga57ub3qks2i	103	25	Snyder	Snyder	NNP
work_624qrp646zf4pdga57ub3qks2i	103	26	SH	SH	NNP
work_624qrp646zf4pdga57ub3qks2i	103	27	.	.	.
work_624qrp646zf4pdga57ub3qks2i	104	1	Poly(ADP	poly(adp	NN
work_624qrp646zf4pdga57ub3qks2i	104	2	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	104	3	ribose	ribose	NN
work_624qrp646zf4pdga57ub3qks2i	104	4	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	104	5	polymerase	polymerase	NN
work_624qrp646zf4pdga57ub3qks2i	104	6	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	104	7	defi-	defi-	JJ
work_624qrp646zf4pdga57ub3qks2i	104	8	cient	cient	NN
work_624qrp646zf4pdga57ub3qks2i	104	9	mice	mouse	NNS
work_624qrp646zf4pdga57ub3qks2i	104	10	are	be	VBP
work_624qrp646zf4pdga57ub3qks2i	104	11	protected	protect	VBN
work_624qrp646zf4pdga57ub3qks2i	104	12	from	from	IN
work_624qrp646zf4pdga57ub3qks2i	104	13	streptozotocin	streptozotocin	NN
work_624qrp646zf4pdga57ub3qks2i	104	14	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	104	15	induced	induce	VBN
work_624qrp646zf4pdga57ub3qks2i	104	16	diabetes	diabete	NNS
work_624qrp646zf4pdga57ub3qks2i	104	17	.	.	.
work_624qrp646zf4pdga57ub3qks2i	105	1	Proc	Proc	NNP
work_624qrp646zf4pdga57ub3qks2i	105	2	Natl	Natl	NNP
work_624qrp646zf4pdga57ub3qks2i	105	3	Acad	Acad	NNP
work_624qrp646zf4pdga57ub3qks2i	105	4	Sci	Sci	NNP
work_624qrp646zf4pdga57ub3qks2i	105	5	USA	USA	NNP
work_624qrp646zf4pdga57ub3qks2i	105	6	96	96	CD
work_624qrp646zf4pdga57ub3qks2i	105	7	:	:	:
work_624qrp646zf4pdga57ub3qks2i	105	8	3059	3059	CD
work_624qrp646zf4pdga57ub3qks2i	105	9	–	–	:
work_624qrp646zf4pdga57ub3qks2i	105	10	3064	3064	CD
work_624qrp646zf4pdga57ub3qks2i	105	11	,	,	,
work_624qrp646zf4pdga57ub3qks2i	105	12	1999	1999	CD
work_624qrp646zf4pdga57ub3qks2i	105	13	.	.	.
work_624qrp646zf4pdga57ub3qks2i	106	1	12	12	CD
work_624qrp646zf4pdga57ub3qks2i	106	2	.	.	.
work_624qrp646zf4pdga57ub3qks2i	107	1	Yamamoto	yamamoto	NN
work_624qrp646zf4pdga57ub3qks2i	107	2	H	h	NN
work_624qrp646zf4pdga57ub3qks2i	107	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	107	4	Uchigata	Uchigata	NNP
work_624qrp646zf4pdga57ub3qks2i	107	5	Y	Y	NNP
work_624qrp646zf4pdga57ub3qks2i	107	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	107	7	Okamoto	Okamoto	NNP
work_624qrp646zf4pdga57ub3qks2i	107	8	H.	H.	NNP
work_624qrp646zf4pdga57ub3qks2i	107	9	DNA	DNA	NNP
work_624qrp646zf4pdga57ub3qks2i	107	10	strand	strand	NN
work_624qrp646zf4pdga57ub3qks2i	107	11	breaks	break	NNS
work_624qrp646zf4pdga57ub3qks2i	107	12	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	107	13	pancre-	pancre-	JJ
work_624qrp646zf4pdga57ub3qks2i	107	14	atic	atic	JJ
work_624qrp646zf4pdga57ub3qks2i	107	15	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	107	16	by	by	IN
work_624qrp646zf4pdga57ub3qks2i	107	17	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	107	18	vivo	vivo	NNP
work_624qrp646zf4pdga57ub3qks2i	107	19	administration	administration	NNP
work_624qrp646zf4pdga57ub3qks2i	107	20	of	of	IN
work_624qrp646zf4pdga57ub3qks2i	107	21	alloxan	alloxan	NNP
work_624qrp646zf4pdga57ub3qks2i	107	22	or	or	CC
work_624qrp646zf4pdga57ub3qks2i	107	23	streptozotocin	streptozotocin	NNP
work_624qrp646zf4pdga57ub3qks2i	107	24	.	.	.
work_624qrp646zf4pdga57ub3qks2i	108	1	Biochem	Biochem	NNP
work_624qrp646zf4pdga57ub3qks2i	108	2	Biophys	Biophys	NNP
work_624qrp646zf4pdga57ub3qks2i	108	3	Res	Res	NNP
work_624qrp646zf4pdga57ub3qks2i	108	4	Commun	Commun	NNP
work_624qrp646zf4pdga57ub3qks2i	108	5	103	103	CD
work_624qrp646zf4pdga57ub3qks2i	108	6	:	:	SYM
work_624qrp646zf4pdga57ub3qks2i	108	7	1014	1014	CD
work_624qrp646zf4pdga57ub3qks2i	108	8	–	–	:
work_624qrp646zf4pdga57ub3qks2i	108	9	1020	1020	CD
work_624qrp646zf4pdga57ub3qks2i	108	10	,	,	,
work_624qrp646zf4pdga57ub3qks2i	108	11	1981	1981	CD
work_624qrp646zf4pdga57ub3qks2i	108	12	.	.	.
work_624qrp646zf4pdga57ub3qks2i	109	1	13	13	CD
work_624qrp646zf4pdga57ub3qks2i	109	2	.	.	.
work_624qrp646zf4pdga57ub3qks2i	110	1	Yamamoto	yamamoto	NN
work_624qrp646zf4pdga57ub3qks2i	110	2	H	h	NN
work_624qrp646zf4pdga57ub3qks2i	110	3	,	,	,
work_624qrp646zf4pdga57ub3qks2i	110	4	Uchigata	Uchigata	NNP
work_624qrp646zf4pdga57ub3qks2i	110	5	Y	Y	NNP
work_624qrp646zf4pdga57ub3qks2i	110	6	,	,	,
work_624qrp646zf4pdga57ub3qks2i	110	7	Okamoto	Okamoto	NNP
work_624qrp646zf4pdga57ub3qks2i	110	8	H.	H.	NNP
work_624qrp646zf4pdga57ub3qks2i	110	9	Streptozotocin	Streptozotocin	NNP
work_624qrp646zf4pdga57ub3qks2i	110	10	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	110	11	alloxan	alloxan	NNP
work_624qrp646zf4pdga57ub3qks2i	110	12	induce	induce	VBP
work_624qrp646zf4pdga57ub3qks2i	110	13	DNA	dna	NN
work_624qrp646zf4pdga57ub3qks2i	110	14	strand	strand	NN
work_624qrp646zf4pdga57ub3qks2i	110	15	breaks	break	NNS
work_624qrp646zf4pdga57ub3qks2i	110	16	and	and	CC
work_624qrp646zf4pdga57ub3qks2i	110	17	poly(ADP	poly(adp	NN
work_624qrp646zf4pdga57ub3qks2i	110	18	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	110	19	ribose	ribose	NN
work_624qrp646zf4pdga57ub3qks2i	110	20	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	110	21	synthetase	synthetase	VB
work_624qrp646zf4pdga57ub3qks2i	110	22	in	in	IN
work_624qrp646zf4pdga57ub3qks2i	110	23	pancreatic	pancreatic	JJ
work_624qrp646zf4pdga57ub3qks2i	110	24	islets	islet	NNS
work_624qrp646zf4pdga57ub3qks2i	110	25	.	.	.
work_624qrp646zf4pdga57ub3qks2i	111	1	Nature	nature	NN
work_624qrp646zf4pdga57ub3qks2i	111	2	294	294	CD
work_624qrp646zf4pdga57ub3qks2i	111	3	:	:	:
work_624qrp646zf4pdga57ub3qks2i	111	4	284	284	CD
work_624qrp646zf4pdga57ub3qks2i	111	5	–	–	:
work_624qrp646zf4pdga57ub3qks2i	111	6	286	286	CD
work_624qrp646zf4pdga57ub3qks2i	111	7	,	,	,
work_624qrp646zf4pdga57ub3qks2i	111	8	1981	1981	CD
work_624qrp646zf4pdga57ub3qks2i	111	9	.	.	.
work_624qrp646zf4pdga57ub3qks2i	112	1	Editorial	Editorial	NNP
work_624qrp646zf4pdga57ub3qks2i	112	2	Focus	Focus	NNP
work_624qrp646zf4pdga57ub3qks2i	112	3	E171PARP-1	E171PARP-1	NNP
work_624qrp646zf4pdga57ub3qks2i	112	4	AND	and	CC
work_624qrp646zf4pdga57ub3qks2i	112	5	CYTOKINE	CYTOKINE	NNP
work_624qrp646zf4pdga57ub3qks2i	112	6	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	112	7	MEDIATED	mediate	VBN
work_624qrp646zf4pdga57ub3qks2i	112	8	�	�	NNP
work_624qrp646zf4pdga57ub3qks2i	112	9	-CELL	-CELL	.
work_624qrp646zf4pdga57ub3qks2i	112	10	DEATH	DEATH	NNP
work_624qrp646zf4pdga57ub3qks2i	112	11	AJP	AJP	NNP
work_624qrp646zf4pdga57ub3qks2i	112	12	-	-	HYPH
work_624qrp646zf4pdga57ub3qks2i	112	13	Endocrinol	Endocrinol	NNP
work_624qrp646zf4pdga57ub3qks2i	112	14	Metab	Metab	NNP
work_624qrp646zf4pdga57ub3qks2i	112	15	•	•	VBP
work_624qrp646zf4pdga57ub3qks2i	112	16	doi:10.1152	doi:10.1152	NN
work_624qrp646zf4pdga57ub3qks2i	112	17	/	/	SYM
work_624qrp646zf4pdga57ub3qks2i	112	18	ajpendo.00226.2012	ajpendo.00226.2012	NN
work_624qrp646zf4pdga57ub3qks2i	112	19	•	•	NNP
work_624qrp646zf4pdga57ub3qks2i	112	20	www.ajpendo.org	www.ajpendo.org	NN
work_624qrp646zf4pdga57ub3qks2i	112	21	Downloaded	download	VBN
work_624qrp646zf4pdga57ub3qks2i	112	22	from	from	IN
work_624qrp646zf4pdga57ub3qks2i	112	23	journals.physiology.org/journal/ajpendo	journals.physiology.org/journal/ajpendo	NNS
work_624qrp646zf4pdga57ub3qks2i	112	24	at	at	IN
work_624qrp646zf4pdga57ub3qks2i	112	25	Carnegie	Carnegie	NNP
work_624qrp646zf4pdga57ub3qks2i	112	26	Mellon	Mellon	NNP
work_624qrp646zf4pdga57ub3qks2i	112	27	Univ	Univ	NNP
work_624qrp646zf4pdga57ub3qks2i	112	28	(	(	-LRB-
work_624qrp646zf4pdga57ub3qks2i	112	29	128.182.081.034	128.182.081.034	CD
work_624qrp646zf4pdga57ub3qks2i	112	30	)	)	-RRB-
work_624qrp646zf4pdga57ub3qks2i	112	31	on	on	IN
work_624qrp646zf4pdga57ub3qks2i	112	32	April	April	NNP
work_624qrp646zf4pdga57ub3qks2i	112	33	5	5	CD
work_624qrp646zf4pdga57ub3qks2i	112	34	,	,	,
work_624qrp646zf4pdga57ub3qks2i	112	35	2021	2021	CD
work_624qrp646zf4pdga57ub3qks2i	112	36	.	.	.
work_624qrp646zf4pdga57ub3qks2i	112	37	http://dx.doi.org/10.1152/ajpendo.00055.2012	http://dx.doi.org/10.1152/ajpendo.00055.2012	NNP