id sid tid token lemma pos work_mx2qellqbfbvhd32ao5o5yu3fu 1 1 Tipping tip VBG work_mx2qellqbfbvhd32ao5o5yu3fu 1 2 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 1 3 Energy Energy NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 4 Balance Balance NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 5 toward toward IN work_mx2qellqbfbvhd32ao5o5yu3fu 1 6 Longevity Longevity NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 7 Cell Cell NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 8 Metabolism Metabolism NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 9 Previews Previews NNPS work_mx2qellqbfbvhd32ao5o5yu3fu 1 10 Tipping tip VBG work_mx2qellqbfbvhd32ao5o5yu3fu 1 11 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 1 12 Energy Energy NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 13 Balance Balance NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 14 toward toward IN work_mx2qellqbfbvhd32ao5o5yu3fu 1 15 Longevity Longevity NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 16 William William NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 17 Mair1 mair1 NN work_mx2qellqbfbvhd32ao5o5yu3fu 1 18 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 1 19 * * NFP work_mx2qellqbfbvhd32ao5o5yu3fu 1 20 1Department 1department CD work_mx2qellqbfbvhd32ao5o5yu3fu 1 21 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 1 22 Genetics Genetics NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 23 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 1 24 Complex Complex NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 25 Diseases Diseases NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 26 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 1 27 Harvard Harvard NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 28 School School NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 29 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 1 30 Public Public NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 31 Health Health NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 32 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 1 33 665 665 CD work_mx2qellqbfbvhd32ao5o5yu3fu 1 34 Huntington Huntington NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 35 Avenue Avenue NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 36 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 1 37 Boston Boston NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 38 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 1 39 MA MA NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 40 02115 02115 CD work_mx2qellqbfbvhd32ao5o5yu3fu 1 41 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 1 42 USA USA NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 43 * * NFP work_mx2qellqbfbvhd32ao5o5yu3fu 1 44 Correspondence correspondence NN work_mx2qellqbfbvhd32ao5o5yu3fu 1 45 : : : work_mx2qellqbfbvhd32ao5o5yu3fu 1 46 wmair@hsph.harvard.edu wmair@hsph.harvard.edu NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 47 http://dx.doi.org/10.1016/j.cmet.2012.11.011 http://dx.doi.org/10.1016/j.cmet.2012.11.011 NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 48 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 49 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 1 50 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 1 51 cellular cellular JJ work_mx2qellqbfbvhd32ao5o5yu3fu 1 52 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 1 53 sensor sensor NN work_mx2qellqbfbvhd32ao5o5yu3fu 1 54 conserved conserve VBN work_mx2qellqbfbvhd32ao5o5yu3fu 1 55 across across IN work_mx2qellqbfbvhd32ao5o5yu3fu 1 56 eukaryotes eukaryote NNS work_mx2qellqbfbvhd32ao5o5yu3fu 1 57 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 1 58 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 1 59 C. C. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 60 elegans elegan VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 1 61 prolongs prolong NNS work_mx2qellqbfbvhd32ao5o5yu3fu 1 62 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 1 63 span span NN work_mx2qellqbfbvhd32ao5o5yu3fu 1 64 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 1 65 mimics mimics NNP work_mx2qellqbfbvhd32ao5o5yu3fu 1 66 dietary dietary JJ work_mx2qellqbfbvhd32ao5o5yu3fu 1 67 restriction restriction NN work_mx2qellqbfbvhd32ao5o5yu3fu 1 68 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 2 1 Stenesen Stenesen NNP work_mx2qellqbfbvhd32ao5o5yu3fu 2 2 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 2 3 colleagues colleague NNS work_mx2qellqbfbvhd32ao5o5yu3fu 2 4 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 2 5 2012 2012 CD work_mx2qellqbfbvhd32ao5o5yu3fu 2 6 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 2 7 activate activate VBP work_mx2qellqbfbvhd32ao5o5yu3fu 2 8 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 2 9 both both CC work_mx2qellqbfbvhd32ao5o5yu3fu 2 10 directly directly RB work_mx2qellqbfbvhd32ao5o5yu3fu 2 11 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 2 12 indirectly indirectly RB work_mx2qellqbfbvhd32ao5o5yu3fu 2 13 by by IN work_mx2qellqbfbvhd32ao5o5yu3fu 2 14 altering alter VBG work_mx2qellqbfbvhd32ao5o5yu3fu 2 15 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 2 16 biosynthesis biosynthesis NN work_mx2qellqbfbvhd32ao5o5yu3fu 2 17 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 2 18 slow slow VB work_mx2qellqbfbvhd32ao5o5yu3fu 2 19 aging aging NN work_mx2qellqbfbvhd32ao5o5yu3fu 2 20 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 2 21 Drosophila Drosophila NNP work_mx2qellqbfbvhd32ao5o5yu3fu 2 22 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 2 23 highlighting highlight VBG work_mx2qellqbfbvhd32ao5o5yu3fu 2 24 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 2 25 as as IN work_mx2qellqbfbvhd32ao5o5yu3fu 2 26 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 2 27 conserved conserve VBN work_mx2qellqbfbvhd32ao5o5yu3fu 2 28 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 2 29 span span NN work_mx2qellqbfbvhd32ao5o5yu3fu 2 30 modulator modulator NN work_mx2qellqbfbvhd32ao5o5yu3fu 2 31 that that WDT work_mx2qellqbfbvhd32ao5o5yu3fu 2 32 links link VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 2 33 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 2 34 sensing sensing NN work_mx2qellqbfbvhd32ao5o5yu3fu 2 35 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 2 36 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 2 37 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 3 1 For for IN work_mx2qellqbfbvhd32ao5o5yu3fu 3 2 an an DT work_mx2qellqbfbvhd32ao5o5yu3fu 3 3 organism organism NN work_mx2qellqbfbvhd32ao5o5yu3fu 3 4 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 3 5 survive survive VB work_mx2qellqbfbvhd32ao5o5yu3fu 3 6 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 3 7 it -PRON- PRP work_mx2qellqbfbvhd32ao5o5yu3fu 3 8 must must MD work_mx2qellqbfbvhd32ao5o5yu3fu 3 9 main- main- XX work_mx2qellqbfbvhd32ao5o5yu3fu 3 10 tain tain VB work_mx2qellqbfbvhd32ao5o5yu3fu 3 11 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 3 12 homeostasis homeostasis NN work_mx2qellqbfbvhd32ao5o5yu3fu 3 13 by by IN work_mx2qellqbfbvhd32ao5o5yu3fu 3 14 tightly tightly RB work_mx2qellqbfbvhd32ao5o5yu3fu 3 15 regu- regu- JJ work_mx2qellqbfbvhd32ao5o5yu3fu 3 16 lating lating NN work_mx2qellqbfbvhd32ao5o5yu3fu 3 17 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 3 18 balance balance NN work_mx2qellqbfbvhd32ao5o5yu3fu 3 19 between between IN work_mx2qellqbfbvhd32ao5o5yu3fu 3 20 anabolic anabolic JJ work_mx2qellqbfbvhd32ao5o5yu3fu 3 21 processes process NNS work_mx2qellqbfbvhd32ao5o5yu3fu 3 22 that that WDT work_mx2qellqbfbvhd32ao5o5yu3fu 3 23 generate generate VBP work_mx2qellqbfbvhd32ao5o5yu3fu 3 24 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 3 25 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 3 26 cata- cata- JJ work_mx2qellqbfbvhd32ao5o5yu3fu 3 27 bolic bolic JJ work_mx2qellqbfbvhd32ao5o5yu3fu 3 28 ones one NNS work_mx2qellqbfbvhd32ao5o5yu3fu 3 29 that that WDT work_mx2qellqbfbvhd32ao5o5yu3fu 3 30 eat eat VBP work_mx2qellqbfbvhd32ao5o5yu3fu 3 31 into into IN work_mx2qellqbfbvhd32ao5o5yu3fu 3 32 reserves reserve NNS work_mx2qellqbfbvhd32ao5o5yu3fu 3 33 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 4 1 Fine- Fine- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 4 2 tuning tuning NN work_mx2qellqbfbvhd32ao5o5yu3fu 4 3 this this DT work_mx2qellqbfbvhd32ao5o5yu3fu 4 4 balance balance NN work_mx2qellqbfbvhd32ao5o5yu3fu 4 5 becomes become VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 4 6 especially especially RB work_mx2qellqbfbvhd32ao5o5yu3fu 4 7 critical critical JJ work_mx2qellqbfbvhd32ao5o5yu3fu 4 8 when when WRB work_mx2qellqbfbvhd32ao5o5yu3fu 4 9 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 4 10 intake intake NNP work_mx2qellqbfbvhd32ao5o5yu3fu 4 11 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 4 12 low low JJ work_mx2qellqbfbvhd32ao5o5yu3fu 4 13 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 4 14 leaving leave VBG work_mx2qellqbfbvhd32ao5o5yu3fu 4 15 cells cell NNS work_mx2qellqbfbvhd32ao5o5yu3fu 4 16 without without IN work_mx2qellqbfbvhd32ao5o5yu3fu 4 17 adequate adequate JJ work_mx2qellqbfbvhd32ao5o5yu3fu 4 18 supply supply NN work_mx2qellqbfbvhd32ao5o5yu3fu 4 19 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 4 20 meet meet VB work_mx2qellqbfbvhd32ao5o5yu3fu 4 21 demand demand NN work_mx2qellqbfbvhd32ao5o5yu3fu 4 22 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 5 1 In in IN work_mx2qellqbfbvhd32ao5o5yu3fu 5 2 such such JJ work_mx2qellqbfbvhd32ao5o5yu3fu 5 3 cases case NNS work_mx2qellqbfbvhd32ao5o5yu3fu 5 4 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 5 5 organisms organism NNS work_mx2qellqbfbvhd32ao5o5yu3fu 5 6 from from IN work_mx2qellqbfbvhd32ao5o5yu3fu 5 7 yeast yeast NN work_mx2qellqbfbvhd32ao5o5yu3fu 5 8 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 5 9 mammals mammal NNS work_mx2qellqbfbvhd32ao5o5yu3fu 5 10 avoid avoid VB work_mx2qellqbfbvhd32ao5o5yu3fu 5 11 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 5 12 crisis crisis NN work_mx2qellqbfbvhd32ao5o5yu3fu 5 13 by by IN work_mx2qellqbfbvhd32ao5o5yu3fu 5 14 implementing implement VBG work_mx2qellqbfbvhd32ao5o5yu3fu 5 15 austerity austerity NN work_mx2qellqbfbvhd32ao5o5yu3fu 5 16 measures measure NNS work_mx2qellqbfbvhd32ao5o5yu3fu 5 17 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 5 18 reallo- reallo- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 5 19 cating cat VBG work_mx2qellqbfbvhd32ao5o5yu3fu 5 20 limited limit VBN work_mx2qellqbfbvhd32ao5o5yu3fu 5 21 resources resource NNS work_mx2qellqbfbvhd32ao5o5yu3fu 5 22 from from IN work_mx2qellqbfbvhd32ao5o5yu3fu 5 23 growth growth NN work_mx2qellqbfbvhd32ao5o5yu3fu 5 24 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 5 25 reproduction reproduction NN work_mx2qellqbfbvhd32ao5o5yu3fu 5 26 toward toward IN work_mx2qellqbfbvhd32ao5o5yu3fu 5 27 self self NN work_mx2qellqbfbvhd32ao5o5yu3fu 5 28 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 5 29 preserva- preserva- JJ work_mx2qellqbfbvhd32ao5o5yu3fu 5 30 tion tion NN work_mx2qellqbfbvhd32ao5o5yu3fu 5 31 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 5 32 survival survival NN work_mx2qellqbfbvhd32ao5o5yu3fu 5 33 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 5 34 Fontana Fontana NNP work_mx2qellqbfbvhd32ao5o5yu3fu 5 35 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 5 36 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 5 37 . . NNP work_mx2qellqbfbvhd32ao5o5yu3fu 5 38 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 5 39 2010 2010 CD work_mx2qellqbfbvhd32ao5o5yu3fu 5 40 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 5 41 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 6 1 Strikingly strikingly RB work_mx2qellqbfbvhd32ao5o5yu3fu 6 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 6 3 animals animal NNS work_mx2qellqbfbvhd32ao5o5yu3fu 6 4 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 6 5 this this DT work_mx2qellqbfbvhd32ao5o5yu3fu 6 6 thrifty thrifty JJ work_mx2qellqbfbvhd32ao5o5yu3fu 6 7 state state NN work_mx2qellqbfbvhd32ao5o5yu3fu 6 8 show show NN work_mx2qellqbfbvhd32ao5o5yu3fu 6 9 remarkable remarkable JJ work_mx2qellqbfbvhd32ao5o5yu3fu 6 10 resistance resistance NN work_mx2qellqbfbvhd32ao5o5yu3fu 6 11 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 6 12 multiple multiple JJ work_mx2qellqbfbvhd32ao5o5yu3fu 6 13 age age NN work_mx2qellqbfbvhd32ao5o5yu3fu 6 14 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 6 15 onset onset NN work_mx2qellqbfbvhd32ao5o5yu3fu 6 16 pathologies pathology NNS work_mx2qellqbfbvhd32ao5o5yu3fu 6 17 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 6 18 including include VBG work_mx2qellqbfbvhd32ao5o5yu3fu 6 19 cancer cancer NN work_mx2qellqbfbvhd32ao5o5yu3fu 6 20 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 6 21 metabolic metabolic JJ work_mx2qellqbfbvhd32ao5o5yu3fu 6 22 disease disease NN work_mx2qellqbfbvhd32ao5o5yu3fu 6 23 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 6 24 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 6 25 neurodegenera- neurodegenera- VB work_mx2qellqbfbvhd32ao5o5yu3fu 6 26 tive tive JJ work_mx2qellqbfbvhd32ao5o5yu3fu 6 27 disorders disorder NNS work_mx2qellqbfbvhd32ao5o5yu3fu 6 28 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 7 1 In in IN work_mx2qellqbfbvhd32ao5o5yu3fu 7 2 this this DT work_mx2qellqbfbvhd32ao5o5yu3fu 7 3 issue issue NN work_mx2qellqbfbvhd32ao5o5yu3fu 7 4 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 7 5 Cell Cell NNP work_mx2qellqbfbvhd32ao5o5yu3fu 7 6 Metab- Metab- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 7 7 olism olism NN work_mx2qellqbfbvhd32ao5o5yu3fu 7 8 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 7 9 Stenesen Stenesen NNP work_mx2qellqbfbvhd32ao5o5yu3fu 7 10 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 7 11 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 7 12 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 8 1 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 8 2 2012 2012 CD work_mx2qellqbfbvhd32ao5o5yu3fu 8 3 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 8 4 use use VBP work_mx2qellqbfbvhd32ao5o5yu3fu 8 5 genetic genetic JJ work_mx2qellqbfbvhd32ao5o5yu3fu 8 6 approaches approach NNS work_mx2qellqbfbvhd32ao5o5yu3fu 8 7 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 8 8 disrupt disrupt VB work_mx2qellqbfbvhd32ao5o5yu3fu 8 9 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 10 balance balance NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 11 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 8 12 slow slow JJ work_mx2qellqbfbvhd32ao5o5yu3fu 8 13 aging aging NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 14 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 8 15 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 8 16 fruit fruit NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 17 fly fly NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 18 Drosophila Drosophila NNP work_mx2qellqbfbvhd32ao5o5yu3fu 8 19 melanogaster melanogaster NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 20 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 8 21 reinforcing reinforce VBG work_mx2qellqbfbvhd32ao5o5yu3fu 8 22 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 8 23 idea idea NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 24 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 8 25 energetics energetic NNS work_mx2qellqbfbvhd32ao5o5yu3fu 8 26 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 8 27 metabolism metabolism NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 28 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 8 29 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 30 are be VBP work_mx2qellqbfbvhd32ao5o5yu3fu 8 31 tightly tightly RB work_mx2qellqbfbvhd32ao5o5yu3fu 8 32 linked link VBN work_mx2qellqbfbvhd32ao5o5yu3fu 8 33 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 8 34 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 8 35 altering alter VBG work_mx2qellqbfbvhd32ao5o5yu3fu 8 36 steady- steady- NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 37 state state NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 38 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 39 levels level NNS work_mx2qellqbfbvhd32ao5o5yu3fu 8 40 may may MD work_mx2qellqbfbvhd32ao5o5yu3fu 8 41 be be VB work_mx2qellqbfbvhd32ao5o5yu3fu 8 42 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 8 43 means means NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 44 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 8 45 treat treat VB work_mx2qellqbfbvhd32ao5o5yu3fu 8 46 age age NN work_mx2qellqbfbvhd32ao5o5yu3fu 8 47 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 8 48 related relate VBN work_mx2qellqbfbvhd32ao5o5yu3fu 8 49 diseases disease NNS work_mx2qellqbfbvhd32ao5o5yu3fu 8 50 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 9 1 To to TO work_mx2qellqbfbvhd32ao5o5yu3fu 9 2 identify identify VB work_mx2qellqbfbvhd32ao5o5yu3fu 9 3 genes gene NNS work_mx2qellqbfbvhd32ao5o5yu3fu 9 4 linking link VBG work_mx2qellqbfbvhd32ao5o5yu3fu 9 5 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 9 6 homeostasis homeostasis NN work_mx2qellqbfbvhd32ao5o5yu3fu 9 7 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 9 8 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 9 9 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 9 10 Stenesen Stenesen NNP work_mx2qellqbfbvhd32ao5o5yu3fu 9 11 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 9 12 coworkers coworker NNS work_mx2qellqbfbvhd32ao5o5yu3fu 9 13 performed perform VBD work_mx2qellqbfbvhd32ao5o5yu3fu 9 14 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 9 15 two two CD work_mx2qellqbfbvhd32ao5o5yu3fu 9 16 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 9 17 pronged pronged JJ work_mx2qellqbfbvhd32ao5o5yu3fu 9 18 forward forward JJ work_mx2qellqbfbvhd32ao5o5yu3fu 9 19 genetics genetic NNS work_mx2qellqbfbvhd32ao5o5yu3fu 9 20 screen screen NN work_mx2qellqbfbvhd32ao5o5yu3fu 9 21 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 9 22 Drosophila Drosophila NNP work_mx2qellqbfbvhd32ao5o5yu3fu 9 23 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 9 24 seeking seek VBG work_mx2qellqbfbvhd32ao5o5yu3fu 9 25 mutations mutation NNS work_mx2qellqbfbvhd32ao5o5yu3fu 9 26 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 9 27 both both DT work_mx2qellqbfbvhd32ao5o5yu3fu 9 28 increased increase VBN work_mx2qellqbfbvhd32ao5o5yu3fu 9 29 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 9 30 span span NN work_mx2qellqbfbvhd32ao5o5yu3fu 9 31 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 9 32 specifically specifically RB work_mx2qellqbfbvhd32ao5o5yu3fu 9 33 affected affect VBN work_mx2qellqbfbvhd32ao5o5yu3fu 9 34 genes gene NNS work_mx2qellqbfbvhd32ao5o5yu3fu 9 35 expressed express VBN work_mx2qellqbfbvhd32ao5o5yu3fu 9 36 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 9 37 metabolically metabolically RB work_mx2qellqbfbvhd32ao5o5yu3fu 9 38 active active JJ work_mx2qellqbfbvhd32ao5o5yu3fu 9 39 tissues tissue NNS work_mx2qellqbfbvhd32ao5o5yu3fu 9 40 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 10 1 Of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 10 2 ten ten CD work_mx2qellqbfbvhd32ao5o5yu3fu 10 3 significantly significantly RB work_mx2qellqbfbvhd32ao5o5yu3fu 10 4 long long RB work_mx2qellqbfbvhd32ao5o5yu3fu 10 5 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 10 6 lived live VBN work_mx2qellqbfbvhd32ao5o5yu3fu 10 7 fly fly NN work_mx2qellqbfbvhd32ao5o5yu3fu 10 8 mutants mutant NNS work_mx2qellqbfbvhd32ao5o5yu3fu 10 9 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 10 10 flies fly VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 10 11 carrying carry VBG work_mx2qellqbfbvhd32ao5o5yu3fu 10 12 mutations mutation NNS work_mx2qellqbfbvhd32ao5o5yu3fu 10 13 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 10 14 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 10 15 gene gene NN work_mx2qellqbfbvhd32ao5o5yu3fu 10 16 encoding encode VBG work_mx2qellqbfbvhd32ao5o5yu3fu 10 17 Adenylosuccinate Adenylosuccinate NNP work_mx2qellqbfbvhd32ao5o5yu3fu 10 18 Synthetase Synthetase NNP work_mx2qellqbfbvhd32ao5o5yu3fu 10 19 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 10 20 AdSS AdSS NNP work_mx2qellqbfbvhd32ao5o5yu3fu 10 21 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 10 22 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 10 23 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 10 24 key key JJ work_mx2qellqbfbvhd32ao5o5yu3fu 10 25 metabolic metabolic JJ work_mx2qellqbfbvhd32ao5o5yu3fu 10 26 enzyme enzyme NNS work_mx2qellqbfbvhd32ao5o5yu3fu 10 27 involved involve VBN work_mx2qellqbfbvhd32ao5o5yu3fu 10 28 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 10 29 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 10 30 synthesis synthesis NNP work_mx2qellqbfbvhd32ao5o5yu3fu 10 31 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 10 32 adenosine adenosine NNP work_mx2qellqbfbvhd32ao5o5yu3fu 10 33 monophos- monophos- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 10 34 phate phate NN work_mx2qellqbfbvhd32ao5o5yu3fu 10 35 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 10 36 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 10 37 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 10 38 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 10 39 showed show VBD work_mx2qellqbfbvhd32ao5o5yu3fu 10 40 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 10 41 strongest strong JJS work_mx2qellqbfbvhd32ao5o5yu3fu 10 42 effects effect NNS work_mx2qellqbfbvhd32ao5o5yu3fu 10 43 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 11 1 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 11 2 can can MD work_mx2qellqbfbvhd32ao5o5yu3fu 11 3 be be VB work_mx2qellqbfbvhd32ao5o5yu3fu 11 4 generated generate VBN work_mx2qellqbfbvhd32ao5o5yu3fu 11 5 from from IN work_mx2qellqbfbvhd32ao5o5yu3fu 11 6 both both DT work_mx2qellqbfbvhd32ao5o5yu3fu 11 7 de de IN work_mx2qellqbfbvhd32ao5o5yu3fu 11 8 novo novo NNP work_mx2qellqbfbvhd32ao5o5yu3fu 11 9 synthesis synthesis NNP work_mx2qellqbfbvhd32ao5o5yu3fu 11 10 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 11 11 salvage salvage VB work_mx2qellqbfbvhd32ao5o5yu3fu 11 12 path- path- JJ work_mx2qellqbfbvhd32ao5o5yu3fu 11 13 ways way NNS work_mx2qellqbfbvhd32ao5o5yu3fu 11 14 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 11 15 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 11 16 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 11 17 nucleotide nucleotide JJ work_mx2qellqbfbvhd32ao5o5yu3fu 11 18 precursor precursor NN work_mx2qellqbfbvhd32ao5o5yu3fu 11 19 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 11 20 adenosine adenosine NNP work_mx2qellqbfbvhd32ao5o5yu3fu 11 21 triphosphate triphosphate NNP work_mx2qellqbfbvhd32ao5o5yu3fu 11 22 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 11 23 ATP ATP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 11 24 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 11 25 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 11 26 which which WDT work_mx2qellqbfbvhd32ao5o5yu3fu 11 27 acts act VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 11 28 as as IN work_mx2qellqbfbvhd32ao5o5yu3fu 11 29 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 11 30 critical critical JJ work_mx2qellqbfbvhd32ao5o5yu3fu 11 31 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 11 32 source source NN work_mx2qellqbfbvhd32ao5o5yu3fu 11 33 for for IN work_mx2qellqbfbvhd32ao5o5yu3fu 11 34 most most JJS work_mx2qellqbfbvhd32ao5o5yu3fu 11 35 cellular cellular JJ work_mx2qellqbfbvhd32ao5o5yu3fu 11 36 processes process NNS work_mx2qellqbfbvhd32ao5o5yu3fu 11 37 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 12 1 Confirming confirm VBG work_mx2qellqbfbvhd32ao5o5yu3fu 12 2 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 12 3 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 12 4 increase increase NN work_mx2qellqbfbvhd32ao5o5yu3fu 12 5 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 12 6 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 12 7 was be VBD work_mx2qellqbfbvhd32ao5o5yu3fu 12 8 not not RB work_mx2qellqbfbvhd32ao5o5yu3fu 12 9 specific specific JJ work_mx2qellqbfbvhd32ao5o5yu3fu 12 10 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 12 11 AdSS AdSS NNP work_mx2qellqbfbvhd32ao5o5yu3fu 12 12 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 12 13 Stenesen Stenesen NNP work_mx2qellqbfbvhd32ao5o5yu3fu 12 14 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 12 15 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 12 16 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 13 1 tested test VBD work_mx2qellqbfbvhd32ao5o5yu3fu 13 2 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 13 3 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 13 4 span span NN work_mx2qellqbfbvhd32ao5o5yu3fu 13 5 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 13 6 flies fly NNS work_mx2qellqbfbvhd32ao5o5yu3fu 13 7 harboring harbor VBG work_mx2qellqbfbvhd32ao5o5yu3fu 13 8 mutants mutant NNS work_mx2qellqbfbvhd32ao5o5yu3fu 13 9 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 13 10 multiple multiple JJ work_mx2qellqbfbvhd32ao5o5yu3fu 13 11 genes gene NNS work_mx2qellqbfbvhd32ao5o5yu3fu 13 12 involved involve VBN work_mx2qellqbfbvhd32ao5o5yu3fu 13 13 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 13 14 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 13 15 biosyn- biosyn- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 13 16 thesis thesis NN work_mx2qellqbfbvhd32ao5o5yu3fu 13 17 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 13 18 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 13 19 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 13 20 each each DT work_mx2qellqbfbvhd32ao5o5yu3fu 13 21 case case NN work_mx2qellqbfbvhd32ao5o5yu3fu 13 22 they -PRON- PRP work_mx2qellqbfbvhd32ao5o5yu3fu 13 23 saw see VBD work_mx2qellqbfbvhd32ao5o5yu3fu 13 24 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 13 25 span span NN work_mx2qellqbfbvhd32ao5o5yu3fu 13 26 extension extension NN work_mx2qellqbfbvhd32ao5o5yu3fu 13 27 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 14 1 To to TO work_mx2qellqbfbvhd32ao5o5yu3fu 14 2 determine determine VB work_mx2qellqbfbvhd32ao5o5yu3fu 14 3 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 14 4 effect effect NN work_mx2qellqbfbvhd32ao5o5yu3fu 14 5 these these DT work_mx2qellqbfbvhd32ao5o5yu3fu 14 6 prolon- prolon- NN work_mx2qellqbfbvhd32ao5o5yu3fu 14 7 gevity gevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 14 8 mutations mutation NNS work_mx2qellqbfbvhd32ao5o5yu3fu 14 9 were be VBD work_mx2qellqbfbvhd32ao5o5yu3fu 14 10 having have VBG work_mx2qellqbfbvhd32ao5o5yu3fu 14 11 on on IN work_mx2qellqbfbvhd32ao5o5yu3fu 14 12 cellular cellular JJ work_mx2qellqbfbvhd32ao5o5yu3fu 14 13 energetics energetic NNS work_mx2qellqbfbvhd32ao5o5yu3fu 14 14 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 14 15 Stenesen Stenesen NNP work_mx2qellqbfbvhd32ao5o5yu3fu 14 16 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 14 17 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 14 18 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 15 1 used use VBN work_mx2qellqbfbvhd32ao5o5yu3fu 15 2 high high JJ work_mx2qellqbfbvhd32ao5o5yu3fu 15 3 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 15 4 per- per- NN work_mx2qellqbfbvhd32ao5o5yu3fu 15 5 formance formance NN work_mx2qellqbfbvhd32ao5o5yu3fu 15 6 liquid liquid NN work_mx2qellqbfbvhd32ao5o5yu3fu 15 7 chromatography chromatography NN work_mx2qellqbfbvhd32ao5o5yu3fu 15 8 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 15 9 HPLC HPLC NNP work_mx2qellqbfbvhd32ao5o5yu3fu 15 10 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 15 11 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 15 12 measure measure VB work_mx2qellqbfbvhd32ao5o5yu3fu 15 13 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 15 14 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 15 15 ATP atp NN work_mx2qellqbfbvhd32ao5o5yu3fu 15 16 availability availability NN work_mx2qellqbfbvhd32ao5o5yu3fu 15 17 as as IN work_mx2qellqbfbvhd32ao5o5yu3fu 15 18 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 15 19 readout readout NN work_mx2qellqbfbvhd32ao5o5yu3fu 15 20 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 15 21 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 15 22 balance balance NN work_mx2qellqbfbvhd32ao5o5yu3fu 15 23 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 16 1 Surprisingly surprisingly RB work_mx2qellqbfbvhd32ao5o5yu3fu 16 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 16 3 despite despite IN work_mx2qellqbfbvhd32ao5o5yu3fu 16 4 disrupting disrupt VBG work_mx2qellqbfbvhd32ao5o5yu3fu 16 5 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 16 6 biosynthesis biosynthesis NN work_mx2qellqbfbvhd32ao5o5yu3fu 16 7 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 16 8 each each DT work_mx2qellqbfbvhd32ao5o5yu3fu 16 9 long long RB work_mx2qellqbfbvhd32ao5o5yu3fu 16 10 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 16 11 lived live VBN work_mx2qellqbfbvhd32ao5o5yu3fu 16 12 mutant mutant NN work_mx2qellqbfbvhd32ao5o5yu3fu 16 13 showed show VBD work_mx2qellqbfbvhd32ao5o5yu3fu 16 14 increases increase NNS work_mx2qellqbfbvhd32ao5o5yu3fu 16 15 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 16 16 both both DT work_mx2qellqbfbvhd32ao5o5yu3fu 16 17 total total JJ work_mx2qellqbfbvhd32ao5o5yu3fu 16 18 AMP amp NN work_mx2qellqbfbvhd32ao5o5yu3fu 16 19 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 16 20 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 16 21 ratio ratio NN work_mx2qellqbfbvhd32ao5o5yu3fu 16 22 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 16 23 AMP::ATP amp::atp CD work_mx2qellqbfbvhd32ao5o5yu3fu 16 24 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 16 25 mimicking mimic VBG work_mx2qellqbfbvhd32ao5o5yu3fu 16 26 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 16 27 effects effect NNS work_mx2qellqbfbvhd32ao5o5yu3fu 16 28 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 16 29 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 16 30 depletion depletion NN work_mx2qellqbfbvhd32ao5o5yu3fu 16 31 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 16 32 Figure Figure NNP work_mx2qellqbfbvhd32ao5o5yu3fu 16 33 1 1 CD work_mx2qellqbfbvhd32ao5o5yu3fu 16 34 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 16 35 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 17 1 Increases increase NNS work_mx2qellqbfbvhd32ao5o5yu3fu 17 2 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 17 3 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 17 4 AMP::ATP amp::atp CD work_mx2qellqbfbvhd32ao5o5yu3fu 17 5 ratio ratio NN work_mx2qellqbfbvhd32ao5o5yu3fu 17 6 are be VBP work_mx2qellqbfbvhd32ao5o5yu3fu 17 7 indicative indicative JJ work_mx2qellqbfbvhd32ao5o5yu3fu 17 8 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 17 9 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 17 10 imbalance imbalance NN work_mx2qellqbfbvhd32ao5o5yu3fu 17 11 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 17 12 with with IN work_mx2qellqbfbvhd32ao5o5yu3fu 17 13 more more JJR work_mx2qellqbfbvhd32ao5o5yu3fu 17 14 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 17 15 being be VBG work_mx2qellqbfbvhd32ao5o5yu3fu 17 16 utilized utilize VBN work_mx2qellqbfbvhd32ao5o5yu3fu 17 17 than than IN work_mx2qellqbfbvhd32ao5o5yu3fu 17 18 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 17 19 produced produce VBN work_mx2qellqbfbvhd32ao5o5yu3fu 17 20 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 18 1 When when WRB work_mx2qellqbfbvhd32ao5o5yu3fu 18 2 such such JJ work_mx2qellqbfbvhd32ao5o5yu3fu 18 3 imbalance imbalance NN work_mx2qellqbfbvhd32ao5o5yu3fu 18 4 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 18 5 detected detect VBN work_mx2qellqbfbvhd32ao5o5yu3fu 18 6 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 18 7 cells cell NNS work_mx2qellqbfbvhd32ao5o5yu3fu 18 8 attempt attempt VBP work_mx2qellqbfbvhd32ao5o5yu3fu 18 9 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 18 10 restore restore VB work_mx2qellqbfbvhd32ao5o5yu3fu 18 11 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 18 12 homeostasis homeostasis NN work_mx2qellqbfbvhd32ao5o5yu3fu 18 13 by by IN work_mx2qellqbfbvhd32ao5o5yu3fu 18 14 inhibit- inhibit- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 18 15 ing ing NNP work_mx2qellqbfbvhd32ao5o5yu3fu 18 16 anabolic anabolic NN work_mx2qellqbfbvhd32ao5o5yu3fu 18 17 processes process NNS work_mx2qellqbfbvhd32ao5o5yu3fu 18 18 that that WDT work_mx2qellqbfbvhd32ao5o5yu3fu 18 19 use use VBP work_mx2qellqbfbvhd32ao5o5yu3fu 18 20 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 18 21 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 18 22 activating activate VBG work_mx2qellqbfbvhd32ao5o5yu3fu 18 23 catabolic catabolic JJ work_mx2qellqbfbvhd32ao5o5yu3fu 18 24 ones one NNS work_mx2qellqbfbvhd32ao5o5yu3fu 18 25 that that WDT work_mx2qellqbfbvhd32ao5o5yu3fu 18 26 pro- pro- RB work_mx2qellqbfbvhd32ao5o5yu3fu 18 27 duce duce VBP work_mx2qellqbfbvhd32ao5o5yu3fu 18 28 it -PRON- PRP work_mx2qellqbfbvhd32ao5o5yu3fu 18 29 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 19 1 In in IN work_mx2qellqbfbvhd32ao5o5yu3fu 19 2 eukaryotes eukaryote NNS work_mx2qellqbfbvhd32ao5o5yu3fu 19 3 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 19 4 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 19 5 key key JJ work_mx2qellqbfbvhd32ao5o5yu3fu 19 6 orches- orches- JJ work_mx2qellqbfbvhd32ao5o5yu3fu 19 7 trator trator NN work_mx2qellqbfbvhd32ao5o5yu3fu 19 8 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 19 9 this this DT work_mx2qellqbfbvhd32ao5o5yu3fu 19 10 homeostatic homeostatic JJ work_mx2qellqbfbvhd32ao5o5yu3fu 19 11 process process NN work_mx2qellqbfbvhd32ao5o5yu3fu 19 12 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 19 13 AMP amp NN work_mx2qellqbfbvhd32ao5o5yu3fu 19 14 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 19 15 activated activate VBN work_mx2qellqbfbvhd32ao5o5yu3fu 19 16 protein protein NN work_mx2qellqbfbvhd32ao5o5yu3fu 19 17 kinase kinase NN work_mx2qellqbfbvhd32ao5o5yu3fu 19 18 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 19 19 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 19 20 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 19 21 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 19 22 which which WDT work_mx2qellqbfbvhd32ao5o5yu3fu 19 23 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 19 24 activated activate VBN work_mx2qellqbfbvhd32ao5o5yu3fu 19 25 by by IN work_mx2qellqbfbvhd32ao5o5yu3fu 19 26 increased increase VBN work_mx2qellqbfbvhd32ao5o5yu3fu 19 27 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 19 28 : : : work_mx2qellqbfbvhd32ao5o5yu3fu 19 29 : : : work_mx2qellqbfbvhd32ao5o5yu3fu 19 30 ATP ATP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 19 31 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 19 32 as as IN work_mx2qellqbfbvhd32ao5o5yu3fu 19 33 such such JJ work_mx2qellqbfbvhd32ao5o5yu3fu 19 34 acts act NNS work_mx2qellqbfbvhd32ao5o5yu3fu 19 35 as as IN work_mx2qellqbfbvhd32ao5o5yu3fu 19 36 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 19 37 cellular cellular JJ work_mx2qellqbfbvhd32ao5o5yu3fu 19 38 fuel fuel NN work_mx2qellqbfbvhd32ao5o5yu3fu 19 39 gauge gauge NN work_mx2qellqbfbvhd32ao5o5yu3fu 19 40 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 19 41 Hardie Hardie NNP work_mx2qellqbfbvhd32ao5o5yu3fu 19 42 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 19 43 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 19 44 . . NNP work_mx2qellqbfbvhd32ao5o5yu3fu 19 45 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 19 46 2012 2012 CD work_mx2qellqbfbvhd32ao5o5yu3fu 19 47 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 19 48 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 20 1 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 20 2 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 20 3 activated activate VBN work_mx2qellqbfbvhd32ao5o5yu3fu 20 4 during during IN work_mx2qellqbfbvhd32ao5o5yu3fu 20 5 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 20 6 limiting limiting NN work_mx2qellqbfbvhd32ao5o5yu3fu 20 7 condi- condi- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 20 8 tions tion NNS work_mx2qellqbfbvhd32ao5o5yu3fu 20 9 known know VBN work_mx2qellqbfbvhd32ao5o5yu3fu 20 10 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 20 11 extend extend VB work_mx2qellqbfbvhd32ao5o5yu3fu 20 12 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 20 13 span span NN work_mx2qellqbfbvhd32ao5o5yu3fu 20 14 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 20 15 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 20 16 its -PRON- PRP$ work_mx2qellqbfbvhd32ao5o5yu3fu 20 17 dysregulation dysregulation NN work_mx2qellqbfbvhd32ao5o5yu3fu 20 18 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 20 19 associated associate VBN work_mx2qellqbfbvhd32ao5o5yu3fu 20 20 with with IN work_mx2qellqbfbvhd32ao5o5yu3fu 20 21 multiple multiple JJ work_mx2qellqbfbvhd32ao5o5yu3fu 20 22 age age NN work_mx2qellqbfbvhd32ao5o5yu3fu 20 23 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 20 24 related relate VBN work_mx2qellqbfbvhd32ao5o5yu3fu 20 25 diseases disease NNS work_mx2qellqbfbvhd32ao5o5yu3fu 20 26 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 20 27 Steinberg Steinberg NNP work_mx2qellqbfbvhd32ao5o5yu3fu 20 28 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 20 29 Kemp Kemp NNP work_mx2qellqbfbvhd32ao5o5yu3fu 20 30 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 20 31 2009 2009 CD work_mx2qellqbfbvhd32ao5o5yu3fu 20 32 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 20 33 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 21 1 As as IN work_mx2qellqbfbvhd32ao5o5yu3fu 21 2 such such JJ work_mx2qellqbfbvhd32ao5o5yu3fu 21 3 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 21 4 targeting target VBG work_mx2qellqbfbvhd32ao5o5yu3fu 21 5 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 21 6 has have VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 21 7 been be VBN work_mx2qellqbfbvhd32ao5o5yu3fu 21 8 suggested suggest VBN work_mx2qellqbfbvhd32ao5o5yu3fu 21 9 as as IN work_mx2qellqbfbvhd32ao5o5yu3fu 21 10 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 21 11 means means NN work_mx2qellqbfbvhd32ao5o5yu3fu 21 12 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 21 13 reca- reca- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 21 14 pitulating pitulate VBG work_mx2qellqbfbvhd32ao5o5yu3fu 21 15 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 21 16 protective protective JJ work_mx2qellqbfbvhd32ao5o5yu3fu 21 17 effects effect NNS work_mx2qellqbfbvhd32ao5o5yu3fu 21 18 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 21 19 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 21 20 restriction restriction NN work_mx2qellqbfbvhd32ao5o5yu3fu 21 21 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 21 22 Fontana Fontana NNP work_mx2qellqbfbvhd32ao5o5yu3fu 21 23 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 21 24 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 21 25 . . NNP work_mx2qellqbfbvhd32ao5o5yu3fu 21 26 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 21 27 2010 2010 CD work_mx2qellqbfbvhd32ao5o5yu3fu 21 28 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 21 29 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 22 1 How- How- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 22 2 ever ever RB work_mx2qellqbfbvhd32ao5o5yu3fu 22 3 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 22 4 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 22 5 date date NN work_mx2qellqbfbvhd32ao5o5yu3fu 22 6 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 22 7 effect effect NN work_mx2qellqbfbvhd32ao5o5yu3fu 22 8 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 22 9 AMPK ampk JJ work_mx2qellqbfbvhd32ao5o5yu3fu 22 10 activation activation NN work_mx2qellqbfbvhd32ao5o5yu3fu 22 11 on on IN work_mx2qellqbfbvhd32ao5o5yu3fu 22 12 survival survival NN work_mx2qellqbfbvhd32ao5o5yu3fu 22 13 has have VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 22 14 only only RB work_mx2qellqbfbvhd32ao5o5yu3fu 22 15 been be VBN work_mx2qellqbfbvhd32ao5o5yu3fu 22 16 tested test VBN work_mx2qellqbfbvhd32ao5o5yu3fu 22 17 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 22 18 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 22 19 nematode nematode NNP work_mx2qellqbfbvhd32ao5o5yu3fu 22 20 worm worm NNP work_mx2qellqbfbvhd32ao5o5yu3fu 22 21 C. C. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 22 22 elegans elegans NNP work_mx2qellqbfbvhd32ao5o5yu3fu 22 23 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 22 24 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 22 25 result result NN work_mx2qellqbfbvhd32ao5o5yu3fu 22 26 being be VBG work_mx2qellqbfbvhd32ao5o5yu3fu 22 27 long long RB work_mx2qellqbfbvhd32ao5o5yu3fu 22 28 lived live VBN work_mx2qellqbfbvhd32ao5o5yu3fu 22 29 animals animal NNS work_mx2qellqbfbvhd32ao5o5yu3fu 22 30 that that WDT work_mx2qellqbfbvhd32ao5o5yu3fu 22 31 mimicked mimic VBD work_mx2qellqbfbvhd32ao5o5yu3fu 22 32 those those DT work_mx2qellqbfbvhd32ao5o5yu3fu 22 33 under under IN work_mx2qellqbfbvhd32ao5o5yu3fu 22 34 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 22 35 stress stress NN work_mx2qellqbfbvhd32ao5o5yu3fu 22 36 despite despite IN work_mx2qellqbfbvhd32ao5o5yu3fu 22 37 being be VBG work_mx2qellqbfbvhd32ao5o5yu3fu 22 38 well well RB work_mx2qellqbfbvhd32ao5o5yu3fu 22 39 fed fed NNP work_mx2qellqbfbvhd32ao5o5yu3fu 22 40 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 22 41 Apfeld Apfeld NNP work_mx2qellqbfbvhd32ao5o5yu3fu 22 42 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 22 43 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 22 44 . . NNP work_mx2qellqbfbvhd32ao5o5yu3fu 22 45 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 22 46 2004 2004 CD work_mx2qellqbfbvhd32ao5o5yu3fu 22 47 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 22 48 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 23 1 Cell Cell NNP work_mx2qellqbfbvhd32ao5o5yu3fu 23 2 Metabolism Metabolism NNP work_mx2qellqbfbvhd32ao5o5yu3fu 23 3 Stenesen Stenesen NNP work_mx2qellqbfbvhd32ao5o5yu3fu 23 4 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 23 5 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 23 6 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 24 1 tested test VBN work_mx2qellqbfbvhd32ao5o5yu3fu 24 2 whether whether IN work_mx2qellqbfbvhd32ao5o5yu3fu 24 3 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 24 4 was be VBD work_mx2qellqbfbvhd32ao5o5yu3fu 24 5 both both DT work_mx2qellqbfbvhd32ao5o5yu3fu 24 6 necessary necessary JJ work_mx2qellqbfbvhd32ao5o5yu3fu 24 7 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 24 8 sufficient sufficient JJ work_mx2qellqbfbvhd32ao5o5yu3fu 24 9 for for IN work_mx2qellqbfbvhd32ao5o5yu3fu 24 10 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 24 11 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 24 12 effects effect NNS work_mx2qellqbfbvhd32ao5o5yu3fu 24 13 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 24 14 disrupted disrupt VBN work_mx2qellqbfbvhd32ao5o5yu3fu 24 15 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 24 16 biosynthesis biosynthesis NN work_mx2qellqbfbvhd32ao5o5yu3fu 24 17 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 25 1 As as IN work_mx2qellqbfbvhd32ao5o5yu3fu 25 2 expected expect VBN work_mx2qellqbfbvhd32ao5o5yu3fu 25 3 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 25 4 given give VBN work_mx2qellqbfbvhd32ao5o5yu3fu 25 5 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 25 6 rise rise NN work_mx2qellqbfbvhd32ao5o5yu3fu 25 7 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 25 8 AMP::ATP amp::atp NN work_mx2qellqbfbvhd32ao5o5yu3fu 25 9 ratios ratio NNS work_mx2qellqbfbvhd32ao5o5yu3fu 25 10 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 25 11 AMPK ampk JJ work_mx2qellqbfbvhd32ao5o5yu3fu 25 12 activity activity NN work_mx2qellqbfbvhd32ao5o5yu3fu 25 13 was be VBD work_mx2qellqbfbvhd32ao5o5yu3fu 25 14 indeed indeed RB work_mx2qellqbfbvhd32ao5o5yu3fu 25 15 increased increase VBN work_mx2qellqbfbvhd32ao5o5yu3fu 25 16 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 25 17 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 25 18 long long RB work_mx2qellqbfbvhd32ao5o5yu3fu 25 19 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 25 20 lived live VBN work_mx2qellqbfbvhd32ao5o5yu3fu 25 21 flies fly NNS work_mx2qellqbfbvhd32ao5o5yu3fu 25 22 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 26 1 Further further RB work_mx2qellqbfbvhd32ao5o5yu3fu 26 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 26 3 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 26 4 activation activation NN work_mx2qellqbfbvhd32ao5o5yu3fu 26 5 was be VBD work_mx2qellqbfbvhd32ao5o5yu3fu 26 6 required require VBN work_mx2qellqbfbvhd32ao5o5yu3fu 26 7 for for IN work_mx2qellqbfbvhd32ao5o5yu3fu 26 8 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 26 9 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 26 10 effects effect NNS work_mx2qellqbfbvhd32ao5o5yu3fu 26 11 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 26 12 as as IN work_mx2qellqbfbvhd32ao5o5yu3fu 26 13 expressing express VBG work_mx2qellqbfbvhd32ao5o5yu3fu 26 14 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 26 15 dominant dominant JJ work_mx2qellqbfbvhd32ao5o5yu3fu 26 16 negative negative JJ work_mx2qellqbfbvhd32ao5o5yu3fu 26 17 form form NN work_mx2qellqbfbvhd32ao5o5yu3fu 26 18 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 26 19 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 26 20 completely completely RB work_mx2qellqbfbvhd32ao5o5yu3fu 26 21 suppressed suppress VBD work_mx2qellqbfbvhd32ao5o5yu3fu 26 22 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 26 23 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 26 24 span span NN work_mx2qellqbfbvhd32ao5o5yu3fu 26 25 increase increase NN work_mx2qellqbfbvhd32ao5o5yu3fu 26 26 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 26 27 AdSS AdSS NNP work_mx2qellqbfbvhd32ao5o5yu3fu 26 28 mutants mutant NNS work_mx2qellqbfbvhd32ao5o5yu3fu 26 29 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 27 1 In in IN work_mx2qellqbfbvhd32ao5o5yu3fu 27 2 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 27 3 final final JJ work_mx2qellqbfbvhd32ao5o5yu3fu 27 4 tour tour NN work_mx2qellqbfbvhd32ao5o5yu3fu 27 5 de de IN work_mx2qellqbfbvhd32ao5o5yu3fu 27 6 force force NN work_mx2qellqbfbvhd32ao5o5yu3fu 27 7 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 27 8 fly fly VB work_mx2qellqbfbvhd32ao5o5yu3fu 27 9 genetics genetic NNS work_mx2qellqbfbvhd32ao5o5yu3fu 27 10 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 27 11 Stenesen Stenesen NNP work_mx2qellqbfbvhd32ao5o5yu3fu 27 12 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 27 13 coworkers coworker NNS work_mx2qellqbfbvhd32ao5o5yu3fu 27 14 used use VBD work_mx2qellqbfbvhd32ao5o5yu3fu 27 15 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 27 16 conditional conditional JJ work_mx2qellqbfbvhd32ao5o5yu3fu 27 17 gene gene NN work_mx2qellqbfbvhd32ao5o5yu3fu 27 18 switch switch NN work_mx2qellqbfbvhd32ao5o5yu3fu 27 19 system system NN work_mx2qellqbfbvhd32ao5o5yu3fu 27 20 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 27 21 activate activate VB work_mx2qellqbfbvhd32ao5o5yu3fu 27 22 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 27 23 specifically specifically RB work_mx2qellqbfbvhd32ao5o5yu3fu 27 24 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 27 25 metabolic metabolic JJ work_mx2qellqbfbvhd32ao5o5yu3fu 27 26 tissues tissue NNS work_mx2qellqbfbvhd32ao5o5yu3fu 27 27 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 27 28 adult adult NN work_mx2qellqbfbvhd32ao5o5yu3fu 27 29 flies fly NNS work_mx2qellqbfbvhd32ao5o5yu3fu 27 30 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 28 1 The the DT work_mx2qellqbfbvhd32ao5o5yu3fu 28 2 re- re- JJ work_mx2qellqbfbvhd32ao5o5yu3fu 28 3 sulting sulte VBG work_mx2qellqbfbvhd32ao5o5yu3fu 28 4 AMPK ampk JJ work_mx2qellqbfbvhd32ao5o5yu3fu 28 5 gain gain NN work_mx2qellqbfbvhd32ao5o5yu3fu 28 6 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 28 7 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 28 8 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 28 9 function function NN work_mx2qellqbfbvhd32ao5o5yu3fu 28 10 animals animal NNS work_mx2qellqbfbvhd32ao5o5yu3fu 28 11 showed show VBD work_mx2qellqbfbvhd32ao5o5yu3fu 28 12 increases increase NNS work_mx2qellqbfbvhd32ao5o5yu3fu 28 13 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 28 14 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 28 15 span span VBP work_mx2qellqbfbvhd32ao5o5yu3fu 28 16 comparable comparable JJ work_mx2qellqbfbvhd32ao5o5yu3fu 28 17 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 28 18 that that DT work_mx2qellqbfbvhd32ao5o5yu3fu 28 19 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 28 20 AdSS AdSS NNP work_mx2qellqbfbvhd32ao5o5yu3fu 28 21 mutants mutant NNS work_mx2qellqbfbvhd32ao5o5yu3fu 28 22 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 28 23 suggesting suggest VBG work_mx2qellqbfbvhd32ao5o5yu3fu 28 24 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 28 25 increased increase VBN work_mx2qellqbfbvhd32ao5o5yu3fu 28 26 AMPK ampk JJ work_mx2qellqbfbvhd32ao5o5yu3fu 28 27 activity activity NN work_mx2qellqbfbvhd32ao5o5yu3fu 28 28 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 28 29 sufficient sufficient JJ work_mx2qellqbfbvhd32ao5o5yu3fu 28 30 for for IN work_mx2qellqbfbvhd32ao5o5yu3fu 28 31 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 28 32 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 28 33 effects effect NNS work_mx2qellqbfbvhd32ao5o5yu3fu 28 34 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 28 35 disruptions disruption NNS work_mx2qellqbfbvhd32ao5o5yu3fu 28 36 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 28 37 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 28 38 biosynthesis biosynthesis NN work_mx2qellqbfbvhd32ao5o5yu3fu 28 39 pathways pathway NNS work_mx2qellqbfbvhd32ao5o5yu3fu 28 40 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 29 1 These these DT work_mx2qellqbfbvhd32ao5o5yu3fu 29 2 data datum NNS work_mx2qellqbfbvhd32ao5o5yu3fu 29 3 support support VBP work_mx2qellqbfbvhd32ao5o5yu3fu 29 4 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 29 5 theory theory NN work_mx2qellqbfbvhd32ao5o5yu3fu 29 6 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 29 7 tar- tar- VBP work_mx2qellqbfbvhd32ao5o5yu3fu 29 8 geting get VBG work_mx2qellqbfbvhd32ao5o5yu3fu 29 9 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 29 10 might may MD work_mx2qellqbfbvhd32ao5o5yu3fu 29 11 ameliorate ameliorate VB work_mx2qellqbfbvhd32ao5o5yu3fu 29 12 diseases disease NNS work_mx2qellqbfbvhd32ao5o5yu3fu 29 13 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 29 14 aging aging NN work_mx2qellqbfbvhd32ao5o5yu3fu 29 15 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 29 16 but but CC work_mx2qellqbfbvhd32ao5o5yu3fu 29 17 also also RB work_mx2qellqbfbvhd32ao5o5yu3fu 29 18 raise raise VB work_mx2qellqbfbvhd32ao5o5yu3fu 29 19 further further JJ work_mx2qellqbfbvhd32ao5o5yu3fu 29 20 questions question NNS work_mx2qellqbfbvhd32ao5o5yu3fu 29 21 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 30 1 First first RB work_mx2qellqbfbvhd32ao5o5yu3fu 30 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 30 3 what what WP work_mx2qellqbfbvhd32ao5o5yu3fu 30 4 are be VBP work_mx2qellqbfbvhd32ao5o5yu3fu 30 5 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 30 6 identities identity NNS work_mx2qellqbfbvhd32ao5o5yu3fu 30 7 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 30 8 down- down- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 30 9 stream stream NN work_mx2qellqbfbvhd32ao5o5yu3fu 30 10 mediators mediator NNS work_mx2qellqbfbvhd32ao5o5yu3fu 30 11 responsible responsible JJ work_mx2qellqbfbvhd32ao5o5yu3fu 30 12 for for IN work_mx2qellqbfbvhd32ao5o5yu3fu 30 13 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 30 14 effects effect NNS work_mx2qellqbfbvhd32ao5o5yu3fu 30 15 ? ? . work_mx2qellqbfbvhd32ao5o5yu3fu 31 1 Life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 31 2 span span VBP work_mx2qellqbfbvhd32ao5o5yu3fu 31 3 extension extension NN work_mx2qellqbfbvhd32ao5o5yu3fu 31 4 by by IN work_mx2qellqbfbvhd32ao5o5yu3fu 31 5 activating activate VBG work_mx2qellqbfbvhd32ao5o5yu3fu 31 6 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 31 7 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 31 8 C. C. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 31 9 elegans elegan NNS work_mx2qellqbfbvhd32ao5o5yu3fu 31 10 requires require VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 31 11 both both CC work_mx2qellqbfbvhd32ao5o5yu3fu 31 12 activa- activa- JJ work_mx2qellqbfbvhd32ao5o5yu3fu 31 13 tion tion NN work_mx2qellqbfbvhd32ao5o5yu3fu 31 14 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 31 15 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 31 16 FOXO FOXO NNP work_mx2qellqbfbvhd32ao5o5yu3fu 31 17 transcription transcription NN work_mx2qellqbfbvhd32ao5o5yu3fu 31 18 factor factor NN work_mx2qellqbfbvhd32ao5o5yu3fu 31 19 DAF- DAF- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 31 20 16 16 CD work_mx2qellqbfbvhd32ao5o5yu3fu 31 21 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 31 22 Greer Greer NNP work_mx2qellqbfbvhd32ao5o5yu3fu 31 23 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 31 24 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 31 25 . . NNP work_mx2qellqbfbvhd32ao5o5yu3fu 31 26 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 31 27 2007 2007 CD work_mx2qellqbfbvhd32ao5o5yu3fu 31 28 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 31 29 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 31 30 inactivation inactivation NN work_mx2qellqbfbvhd32ao5o5yu3fu 31 31 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 31 32 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 31 33 transcriptional transcriptional JJ work_mx2qellqbfbvhd32ao5o5yu3fu 31 34 coactivator coactivator NN work_mx2qellqbfbvhd32ao5o5yu3fu 31 35 CRTC-1 CRTC-1 NNS work_mx2qellqbfbvhd32ao5o5yu3fu 31 36 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 31 37 Mair Mair NNP work_mx2qellqbfbvhd32ao5o5yu3fu 31 38 et et FW work_mx2qellqbfbvhd32ao5o5yu3fu 31 39 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 31 40 . . NNP work_mx2qellqbfbvhd32ao5o5yu3fu 31 41 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 31 42 2011 2011 CD work_mx2qellqbfbvhd32ao5o5yu3fu 31 43 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 31 44 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 32 1 Whether whether IN work_mx2qellqbfbvhd32ao5o5yu3fu 32 2 these these DT work_mx2qellqbfbvhd32ao5o5yu3fu 32 3 AMPK ampk JJ work_mx2qellqbfbvhd32ao5o5yu3fu 32 4 targets target NNS work_mx2qellqbfbvhd32ao5o5yu3fu 32 5 work work VBP work_mx2qellqbfbvhd32ao5o5yu3fu 32 6 together together RB work_mx2qellqbfbvhd32ao5o5yu3fu 32 7 or or CC work_mx2qellqbfbvhd32ao5o5yu3fu 32 8 separately separately RB work_mx2qellqbfbvhd32ao5o5yu3fu 32 9 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 32 10 mediate mediate VB work_mx2qellqbfbvhd32ao5o5yu3fu 32 11 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 32 12 remains remain VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 32 13 unclear unclear JJ work_mx2qellqbfbvhd32ao5o5yu3fu 32 14 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 33 1 Both both DT work_mx2qellqbfbvhd32ao5o5yu3fu 33 2 are be VBP work_mx2qellqbfbvhd32ao5o5yu3fu 33 3 well well RB work_mx2qellqbfbvhd32ao5o5yu3fu 33 4 conserved conserve VBN work_mx2qellqbfbvhd32ao5o5yu3fu 33 5 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 33 6 Drosophila Drosophila NNP work_mx2qellqbfbvhd32ao5o5yu3fu 33 7 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 33 8 humans human NNS work_mx2qellqbfbvhd32ao5o5yu3fu 33 9 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 33 10 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 33 11 testing test VBG work_mx2qellqbfbvhd32ao5o5yu3fu 33 12 their -PRON- PRP$ work_mx2qellqbfbvhd32ao5o5yu3fu 33 13 roles role NNS work_mx2qellqbfbvhd32ao5o5yu3fu 33 14 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 33 15 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 33 16 will will MD work_mx2qellqbfbvhd32ao5o5yu3fu 33 17 yield yield VB work_mx2qellqbfbvhd32ao5o5yu3fu 33 18 valuable valuable JJ work_mx2qellqbfbvhd32ao5o5yu3fu 33 19 insight insight NN work_mx2qellqbfbvhd32ao5o5yu3fu 33 20 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 34 1 That that IN work_mx2qellqbfbvhd32ao5o5yu3fu 34 2 disruptions disruption NNS work_mx2qellqbfbvhd32ao5o5yu3fu 34 3 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 34 4 pathways pathway NNS work_mx2qellqbfbvhd32ao5o5yu3fu 34 5 gener- gener- NN work_mx2qellqbfbvhd32ao5o5yu3fu 34 6 ating ating NN work_mx2qellqbfbvhd32ao5o5yu3fu 34 7 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 34 8 results result NNS work_mx2qellqbfbvhd32ao5o5yu3fu 34 9 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 34 10 increased increase VBN work_mx2qellqbfbvhd32ao5o5yu3fu 34 11 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 34 12 levels level NNS work_mx2qellqbfbvhd32ao5o5yu3fu 34 13 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 34 14 counterintuitive counterintuitive JJ work_mx2qellqbfbvhd32ao5o5yu3fu 34 15 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 35 1 Given give VBN work_mx2qellqbfbvhd32ao5o5yu3fu 35 2 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 35 3 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 4 can can MD work_mx2qellqbfbvhd32ao5o5yu3fu 35 5 be be VB work_mx2qellqbfbvhd32ao5o5yu3fu 35 6 generated generate VBN work_mx2qellqbfbvhd32ao5o5yu3fu 35 7 by by IN work_mx2qellqbfbvhd32ao5o5yu3fu 35 8 de de NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 9 novo novo NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 10 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 35 11 salvage salvage NN work_mx2qellqbfbvhd32ao5o5yu3fu 35 12 pathways pathway NNS work_mx2qellqbfbvhd32ao5o5yu3fu 35 13 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 35 14 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 35 15 as as IN work_mx2qellqbfbvhd32ao5o5yu3fu 35 16 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 35 17 byproduct byproduct NN work_mx2qellqbfbvhd32ao5o5yu3fu 35 18 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 35 19 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 35 20 conversion conversion NN work_mx2qellqbfbvhd32ao5o5yu3fu 35 21 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 35 22 ADP ADP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 23 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 35 24 ATP ATP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 25 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 35 26 2ADP 2adp CD work_mx2qellqbfbvhd32ao5o5yu3fu 35 27 # # $ work_mx2qellqbfbvhd32ao5o5yu3fu 35 28 AMP amp NN work_mx2qellqbfbvhd32ao5o5yu3fu 35 29 + + SYM work_mx2qellqbfbvhd32ao5o5yu3fu 35 30 ATP atp NN work_mx2qellqbfbvhd32ao5o5yu3fu 35 31 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 35 32 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 35 33 it -PRON- PRP work_mx2qellqbfbvhd32ao5o5yu3fu 35 34 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 35 35 possible possible JJ work_mx2qellqbfbvhd32ao5o5yu3fu 35 36 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 35 37 inhibiting inhibit VBG work_mx2qellqbfbvhd32ao5o5yu3fu 35 38 one one CD work_mx2qellqbfbvhd32ao5o5yu3fu 35 39 branch branch NN work_mx2qellqbfbvhd32ao5o5yu3fu 35 40 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 35 41 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 42 biosynthesis biosynthesis NN work_mx2qellqbfbvhd32ao5o5yu3fu 35 43 feeds feed VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 35 44 17 17 CD work_mx2qellqbfbvhd32ao5o5yu3fu 35 45 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 35 46 January January NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 47 8 8 CD work_mx2qellqbfbvhd32ao5o5yu3fu 35 48 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 35 49 2013 2013 CD work_mx2qellqbfbvhd32ao5o5yu3fu 35 50 ª2013 ª2013 NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 51 Elsevier Elsevier NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 52 Inc. Inc. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 53 5 5 CD work_mx2qellqbfbvhd32ao5o5yu3fu 35 54 mailto:wmair@hsph.harvard.edu mailto:wmair@hsph.harvard.edu NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 55 http://dx.doi.org/10.1016/j.cmet.2012.11.011 http://dx.doi.org/10.1016/j.cmet.2012.11.011 NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 56 A a DT work_mx2qellqbfbvhd32ao5o5yu3fu 35 57 B B NNP work_mx2qellqbfbvhd32ao5o5yu3fu 35 58 Figure figure NN work_mx2qellqbfbvhd32ao5o5yu3fu 35 59 1 1 CD work_mx2qellqbfbvhd32ao5o5yu3fu 35 60 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 36 1 Tipping tip VBG work_mx2qellqbfbvhd32ao5o5yu3fu 36 2 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 36 3 Energy Energy NNP work_mx2qellqbfbvhd32ao5o5yu3fu 36 4 Balance Balance NNP work_mx2qellqbfbvhd32ao5o5yu3fu 36 5 : : : work_mx2qellqbfbvhd32ao5o5yu3fu 36 6 Mutations mutation NNS work_mx2qellqbfbvhd32ao5o5yu3fu 36 7 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 36 8 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 36 9 Biosynthesis Biosynthesis NNP work_mx2qellqbfbvhd32ao5o5yu3fu 36 10 Pathways Pathways NNPS work_mx2qellqbfbvhd32ao5o5yu3fu 36 11 Increase increase VBP work_mx2qellqbfbvhd32ao5o5yu3fu 36 12 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 36 13 AMP::ATP amp::atp SYM work_mx2qellqbfbvhd32ao5o5yu3fu 36 14 Ratio ratio NN work_mx2qellqbfbvhd32ao5o5yu3fu 36 15 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 36 16 Increase increase VB work_mx2qellqbfbvhd32ao5o5yu3fu 36 17 Longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 36 18 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 36 19 A a NN work_mx2qellqbfbvhd32ao5o5yu3fu 36 20 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 36 21 Under under IN work_mx2qellqbfbvhd32ao5o5yu3fu 36 22 normal normal JJ work_mx2qellqbfbvhd32ao5o5yu3fu 36 23 conditions condition NNS work_mx2qellqbfbvhd32ao5o5yu3fu 36 24 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 36 25 de de NNP work_mx2qellqbfbvhd32ao5o5yu3fu 36 26 novo novo NNP work_mx2qellqbfbvhd32ao5o5yu3fu 36 27 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 36 28 salvage salvage NN work_mx2qellqbfbvhd32ao5o5yu3fu 36 29 pathways pathway NNS work_mx2qellqbfbvhd32ao5o5yu3fu 36 30 are be VBP work_mx2qellqbfbvhd32ao5o5yu3fu 36 31 active active JJ work_mx2qellqbfbvhd32ao5o5yu3fu 36 32 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 36 33 synthesizing synthesize VBG work_mx2qellqbfbvhd32ao5o5yu3fu 36 34 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 36 35 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 36 36 which which WDT work_mx2qellqbfbvhd32ao5o5yu3fu 36 37 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 36 38 con- con- NN work_mx2qellqbfbvhd32ao5o5yu3fu 36 39 verted verte VBN work_mx2qellqbfbvhd32ao5o5yu3fu 36 40 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 36 41 ATP ATP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 36 42 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 36 43 resulting result VBG work_mx2qellqbfbvhd32ao5o5yu3fu 36 44 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 36 45 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 36 46 low low JJ work_mx2qellqbfbvhd32ao5o5yu3fu 36 47 AMP::ATP amp::atp NN work_mx2qellqbfbvhd32ao5o5yu3fu 36 48 ratio ratio NN work_mx2qellqbfbvhd32ao5o5yu3fu 36 49 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 36 50 normal normal JJ work_mx2qellqbfbvhd32ao5o5yu3fu 36 51 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 36 52 span span NN work_mx2qellqbfbvhd32ao5o5yu3fu 36 53 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 37 1 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 37 2 B b NN work_mx2qellqbfbvhd32ao5o5yu3fu 37 3 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 37 4 Mutations Mutations NNPS work_mx2qellqbfbvhd32ao5o5yu3fu 37 5 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 37 6 genes gene NNS work_mx2qellqbfbvhd32ao5o5yu3fu 37 7 involved involve VBN work_mx2qellqbfbvhd32ao5o5yu3fu 37 8 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 37 9 AMP AMP NNP work_mx2qellqbfbvhd32ao5o5yu3fu 37 10 biosynthesis biosynthesis NN work_mx2qellqbfbvhd32ao5o5yu3fu 37 11 swing swing VBP work_mx2qellqbfbvhd32ao5o5yu3fu 37 12 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 37 13 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 37 14 balance balance NN work_mx2qellqbfbvhd32ao5o5yu3fu 37 15 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 37 16 mimic mimic VB work_mx2qellqbfbvhd32ao5o5yu3fu 37 17 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 37 18 low low JJ work_mx2qellqbfbvhd32ao5o5yu3fu 37 19 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 37 20 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 37 21 state state NN work_mx2qellqbfbvhd32ao5o5yu3fu 37 22 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 38 1 AMP::ATP amp::atp NN work_mx2qellqbfbvhd32ao5o5yu3fu 38 2 ratios ratio NNS work_mx2qellqbfbvhd32ao5o5yu3fu 38 3 are be VBP work_mx2qellqbfbvhd32ao5o5yu3fu 38 4 increased increase VBN work_mx2qellqbfbvhd32ao5o5yu3fu 38 5 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 38 6 promoting promote VBG work_mx2qellqbfbvhd32ao5o5yu3fu 38 7 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 38 8 via via IN work_mx2qellqbfbvhd32ao5o5yu3fu 38 9 activation activation NN work_mx2qellqbfbvhd32ao5o5yu3fu 38 10 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 38 11 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 38 12 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 39 1 Cell Cell NNP work_mx2qellqbfbvhd32ao5o5yu3fu 39 2 Metabolism Metabolism NNP work_mx2qellqbfbvhd32ao5o5yu3fu 39 3 Previews Previews NNP work_mx2qellqbfbvhd32ao5o5yu3fu 39 4 back back RB work_mx2qellqbfbvhd32ao5o5yu3fu 39 5 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 39 6 upregulate upregulate VB work_mx2qellqbfbvhd32ao5o5yu3fu 39 7 compensation compensation NN work_mx2qellqbfbvhd32ao5o5yu3fu 39 8 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 39 9 another another DT work_mx2qellqbfbvhd32ao5o5yu3fu 39 10 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 40 1 How how WRB work_mx2qellqbfbvhd32ao5o5yu3fu 40 2 this this DT work_mx2qellqbfbvhd32ao5o5yu3fu 40 3 results result VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 40 4 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 40 5 an an DT work_mx2qellqbfbvhd32ao5o5yu3fu 40 6 increase increase NN work_mx2qellqbfbvhd32ao5o5yu3fu 40 7 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 40 8 AMP::ATP amp::atp CD work_mx2qellqbfbvhd32ao5o5yu3fu 40 9 ratios ratio NNS work_mx2qellqbfbvhd32ao5o5yu3fu 40 10 warrants warrant NNS work_mx2qellqbfbvhd32ao5o5yu3fu 40 11 further further JJ work_mx2qellqbfbvhd32ao5o5yu3fu 40 12 investigation investigation NN work_mx2qellqbfbvhd32ao5o5yu3fu 40 13 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 41 1 Ultimately ultimately RB work_mx2qellqbfbvhd32ao5o5yu3fu 41 2 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 41 3 goal goal NN work_mx2qellqbfbvhd32ao5o5yu3fu 41 4 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 41 5 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 41 6 aging age VBG work_mx2qellqbfbvhd32ao5o5yu3fu 41 7 field field NN work_mx2qellqbfbvhd32ao5o5yu3fu 41 8 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 41 9 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 41 10 generate generate VB work_mx2qellqbfbvhd32ao5o5yu3fu 41 11 small small JJ work_mx2qellqbfbvhd32ao5o5yu3fu 41 12 molecules molecule NNS work_mx2qellqbfbvhd32ao5o5yu3fu 41 13 that that WDT work_mx2qellqbfbvhd32ao5o5yu3fu 41 14 promote promote VBP work_mx2qellqbfbvhd32ao5o5yu3fu 41 15 healthy healthy JJ work_mx2qellqbfbvhd32ao5o5yu3fu 41 16 aging aging NN work_mx2qellqbfbvhd32ao5o5yu3fu 41 17 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 41 18 order order NN work_mx2qellqbfbvhd32ao5o5yu3fu 41 19 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 41 20 treat treat VB work_mx2qellqbfbvhd32ao5o5yu3fu 41 21 age age NN work_mx2qellqbfbvhd32ao5o5yu3fu 41 22 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 41 23 onset onset NN work_mx2qellqbfbvhd32ao5o5yu3fu 41 24 disease disease NN work_mx2qellqbfbvhd32ao5o5yu3fu 41 25 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 41 26 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 41 27 here here RB work_mx2qellqbfbvhd32ao5o5yu3fu 41 28 again again RB work_mx2qellqbfbvhd32ao5o5yu3fu 41 29 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 41 30 new new JJ work_mx2qellqbfbvhd32ao5o5yu3fu 41 31 data datum NNS work_mx2qellqbfbvhd32ao5o5yu3fu 41 32 raise raise VBP work_mx2qellqbfbvhd32ao5o5yu3fu 41 33 interesting interesting JJ work_mx2qellqbfbvhd32ao5o5yu3fu 41 34 questions question NNS work_mx2qellqbfbvhd32ao5o5yu3fu 41 35 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 42 1 Metformin Metformin NNP work_mx2qellqbfbvhd32ao5o5yu3fu 42 2 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 42 3 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 42 4 most most RBS work_mx2qellqbfbvhd32ao5o5yu3fu 42 5 widely widely RB work_mx2qellqbfbvhd32ao5o5yu3fu 42 6 prescribed prescribe VBN work_mx2qellqbfbvhd32ao5o5yu3fu 42 7 treatment treatment NN work_mx2qellqbfbvhd32ao5o5yu3fu 42 8 for for IN work_mx2qellqbfbvhd32ao5o5yu3fu 42 9 type type NN work_mx2qellqbfbvhd32ao5o5yu3fu 42 10 II II NNP work_mx2qellqbfbvhd32ao5o5yu3fu 42 11 diabetes diabetes NN work_mx2qellqbfbvhd32ao5o5yu3fu 42 12 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 42 13 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 42 14 known know VBN work_mx2qellqbfbvhd32ao5o5yu3fu 42 15 potent potent NN work_mx2qellqbfbvhd32ao5o5yu3fu 42 16 acti- acti- FW work_mx2qellqbfbvhd32ao5o5yu3fu 42 17 vator vator NN work_mx2qellqbfbvhd32ao5o5yu3fu 42 18 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 42 19 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 42 20 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 42 21 Hardie Hardie NNP work_mx2qellqbfbvhd32ao5o5yu3fu 42 22 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 42 23 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 42 24 . . NNP work_mx2qellqbfbvhd32ao5o5yu3fu 42 25 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 42 26 2012 2012 CD work_mx2qellqbfbvhd32ao5o5yu3fu 42 27 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 42 28 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 43 1 High high JJ work_mx2qellqbfbvhd32ao5o5yu3fu 43 2 doses dose NNS work_mx2qellqbfbvhd32ao5o5yu3fu 43 3 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 43 4 Metformin Metformin NNP work_mx2qellqbfbvhd32ao5o5yu3fu 43 5 have have VBP work_mx2qellqbfbvhd32ao5o5yu3fu 43 6 been be VBN work_mx2qellqbfbvhd32ao5o5yu3fu 43 7 shown show VBN work_mx2qellqbfbvhd32ao5o5yu3fu 43 8 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 43 9 increase increase VB work_mx2qellqbfbvhd32ao5o5yu3fu 43 10 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 43 11 span span NN work_mx2qellqbfbvhd32ao5o5yu3fu 43 12 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 43 13 C. C. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 43 14 elegans elegan NNS work_mx2qellqbfbvhd32ao5o5yu3fu 43 15 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 43 16 an an DT work_mx2qellqbfbvhd32ao5o5yu3fu 43 17 AMPK ampk JJ work_mx2qellqbfbvhd32ao5o5yu3fu 43 18 dependent dependent JJ work_mx2qellqbfbvhd32ao5o5yu3fu 43 19 manner manner NN work_mx2qellqbfbvhd32ao5o5yu3fu 43 20 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 43 21 Onken Onken VBN work_mx2qellqbfbvhd32ao5o5yu3fu 43 22 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 43 23 Driscoll Driscoll NNP work_mx2qellqbfbvhd32ao5o5yu3fu 43 24 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 43 25 2010 2010 CD work_mx2qellqbfbvhd32ao5o5yu3fu 43 26 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 43 27 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 43 28 yet yet CC work_mx2qellqbfbvhd32ao5o5yu3fu 43 29 recent recent JJ work_mx2qellqbfbvhd32ao5o5yu3fu 43 30 data datum NNS work_mx2qellqbfbvhd32ao5o5yu3fu 43 31 show show VBP work_mx2qellqbfbvhd32ao5o5yu3fu 43 32 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 43 33 this this DT work_mx2qellqbfbvhd32ao5o5yu3fu 43 34 effect effect NN work_mx2qellqbfbvhd32ao5o5yu3fu 43 35 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 43 36 not not RB work_mx2qellqbfbvhd32ao5o5yu3fu 43 37 conserved conserve VBN work_mx2qellqbfbvhd32ao5o5yu3fu 43 38 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 43 39 Drosophila Drosophila NNP work_mx2qellqbfbvhd32ao5o5yu3fu 43 40 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 43 41 Slack Slack NNP work_mx2qellqbfbvhd32ao5o5yu3fu 43 42 et et FW work_mx2qellqbfbvhd32ao5o5yu3fu 43 43 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 43 44 . . NNP work_mx2qellqbfbvhd32ao5o5yu3fu 43 45 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 43 46 2012 2012 CD work_mx2qellqbfbvhd32ao5o5yu3fu 43 47 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 43 48 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 44 1 That that DT work_mx2qellqbfbvhd32ao5o5yu3fu 44 2 activating activate VBG work_mx2qellqbfbvhd32ao5o5yu3fu 44 3 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 44 4 can can MD work_mx2qellqbfbvhd32ao5o5yu3fu 44 5 increase increase VB work_mx2qellqbfbvhd32ao5o5yu3fu 44 6 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 44 7 span span NN work_mx2qellqbfbvhd32ao5o5yu3fu 44 8 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 44 9 fruit fruit NN work_mx2qellqbfbvhd32ao5o5yu3fu 44 10 flies fly NNS work_mx2qellqbfbvhd32ao5o5yu3fu 44 11 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 44 12 6 6 CD work_mx2qellqbfbvhd32ao5o5yu3fu 44 13 Cell Cell NNP work_mx2qellqbfbvhd32ao5o5yu3fu 44 14 Metabolism Metabolism NNP work_mx2qellqbfbvhd32ao5o5yu3fu 44 15 17 17 CD work_mx2qellqbfbvhd32ao5o5yu3fu 44 16 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 44 17 January January NNP work_mx2qellqbfbvhd32ao5o5yu3fu 44 18 8 8 CD work_mx2qellqbfbvhd32ao5o5yu3fu 44 19 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 44 20 2013 2013 CD work_mx2qellqbfbvhd32ao5o5yu3fu 44 21 ª2013 ª2013 NNP work_mx2qellqbfbvhd32ao5o5yu3fu 44 22 yet yet CC work_mx2qellqbfbvhd32ao5o5yu3fu 44 23 Metformin Metformin NNP work_mx2qellqbfbvhd32ao5o5yu3fu 44 24 supplementation supplementation NN work_mx2qellqbfbvhd32ao5o5yu3fu 44 25 does do VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 44 26 not not RB work_mx2qellqbfbvhd32ao5o5yu3fu 44 27 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 44 28 suggests suggest VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 44 29 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 44 30 either either DT work_mx2qellqbfbvhd32ao5o5yu3fu 44 31 feeding feed VBG work_mx2qellqbfbvhd32ao5o5yu3fu 44 32 Metfor- Metfor- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 44 33 min min NN work_mx2qellqbfbvhd32ao5o5yu3fu 44 34 does do VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 44 35 not not RB work_mx2qellqbfbvhd32ao5o5yu3fu 44 36 activate activate VB work_mx2qellqbfbvhd32ao5o5yu3fu 44 37 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 44 38 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 44 39 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 44 40 rele- rele- NN work_mx2qellqbfbvhd32ao5o5yu3fu 44 41 vant vant JJ work_mx2qellqbfbvhd32ao5o5yu3fu 44 42 tissues tissue NNS work_mx2qellqbfbvhd32ao5o5yu3fu 44 43 for for IN work_mx2qellqbfbvhd32ao5o5yu3fu 44 44 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 44 45 span span NN work_mx2qellqbfbvhd32ao5o5yu3fu 44 46 extension extension NN work_mx2qellqbfbvhd32ao5o5yu3fu 44 47 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 44 48 Drosophila Drosophila NNP work_mx2qellqbfbvhd32ao5o5yu3fu 44 49 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 44 50 or or CC work_mx2qellqbfbvhd32ao5o5yu3fu 44 51 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 44 52 off off IN work_mx2qellqbfbvhd32ao5o5yu3fu 44 53 target target NN work_mx2qellqbfbvhd32ao5o5yu3fu 44 54 effects effect NNS work_mx2qellqbfbvhd32ao5o5yu3fu 44 55 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 44 56 Metformin Metformin NNP work_mx2qellqbfbvhd32ao5o5yu3fu 44 57 might may MD work_mx2qellqbfbvhd32ao5o5yu3fu 44 58 be be VB work_mx2qellqbfbvhd32ao5o5yu3fu 44 59 limiting limit VBG work_mx2qellqbfbvhd32ao5o5yu3fu 44 60 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 44 61 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 44 62 spite spite NN work_mx2qellqbfbvhd32ao5o5yu3fu 44 63 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 44 64 its -PRON- PRP$ work_mx2qellqbfbvhd32ao5o5yu3fu 44 65 effects effect NNS work_mx2qellqbfbvhd32ao5o5yu3fu 44 66 on on IN work_mx2qellqbfbvhd32ao5o5yu3fu 44 67 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 44 68 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 45 1 Alternatively alternatively RB work_mx2qellqbfbvhd32ao5o5yu3fu 45 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 45 3 perhaps perhaps RB work_mx2qellqbfbvhd32ao5o5yu3fu 45 4 activating activate VBG work_mx2qellqbfbvhd32ao5o5yu3fu 45 5 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 45 6 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 45 7 all all DT work_mx2qellqbfbvhd32ao5o5yu3fu 45 8 tissues tissue NNS work_mx2qellqbfbvhd32ao5o5yu3fu 45 9 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 45 10 Drosophila Drosophila NNP work_mx2qellqbfbvhd32ao5o5yu3fu 45 11 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 45 12 detrimental detrimental JJ work_mx2qellqbfbvhd32ao5o5yu3fu 45 13 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 45 14 health health NN work_mx2qellqbfbvhd32ao5o5yu3fu 45 15 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 46 1 Ubiq- Ubiq- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 46 2 uitous uitous JJ work_mx2qellqbfbvhd32ao5o5yu3fu 46 3 expression expression NN work_mx2qellqbfbvhd32ao5o5yu3fu 46 4 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 46 5 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 46 6 active active JJ work_mx2qellqbfbvhd32ao5o5yu3fu 46 7 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 46 8 used use VBN work_mx2qellqbfbvhd32ao5o5yu3fu 46 9 by by IN work_mx2qellqbfbvhd32ao5o5yu3fu 46 10 Stenesen Stenesen NNP work_mx2qellqbfbvhd32ao5o5yu3fu 46 11 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 46 12 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 46 13 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 47 1 would would MD work_mx2qellqbfbvhd32ao5o5yu3fu 47 2 determine determine VB work_mx2qellqbfbvhd32ao5o5yu3fu 47 3 whether whether IN work_mx2qellqbfbvhd32ao5o5yu3fu 47 4 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 47 5 promotes promote VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 47 6 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 47 7 non- non- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 47 8 cell cell NN work_mx2qellqbfbvhd32ao5o5yu3fu 47 9 autonomously autonomously RB work_mx2qellqbfbvhd32ao5o5yu3fu 47 10 when when WRB work_mx2qellqbfbvhd32ao5o5yu3fu 47 11 expressed express VBN work_mx2qellqbfbvhd32ao5o5yu3fu 47 12 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 47 13 one one CD work_mx2qellqbfbvhd32ao5o5yu3fu 47 14 tissue tissue NN work_mx2qellqbfbvhd32ao5o5yu3fu 47 15 or or CC work_mx2qellqbfbvhd32ao5o5yu3fu 47 16 whether whether IN work_mx2qellqbfbvhd32ao5o5yu3fu 47 17 tissue tissue NN work_mx2qellqbfbvhd32ao5o5yu3fu 47 18 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 47 19 specific specific JJ work_mx2qellqbfbvhd32ao5o5yu3fu 47 20 acti- acti- JJ work_mx2qellqbfbvhd32ao5o5yu3fu 47 21 vation vation NN work_mx2qellqbfbvhd32ao5o5yu3fu 47 22 simply simply RB work_mx2qellqbfbvhd32ao5o5yu3fu 47 23 recapitulates recapitulate VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 47 24 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 47 25 fraction fraction NN work_mx2qellqbfbvhd32ao5o5yu3fu 47 26 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 47 27 what what WP work_mx2qellqbfbvhd32ao5o5yu3fu 47 28 might may MD work_mx2qellqbfbvhd32ao5o5yu3fu 47 29 be be VB work_mx2qellqbfbvhd32ao5o5yu3fu 47 30 achievable achievable JJ work_mx2qellqbfbvhd32ao5o5yu3fu 47 31 if if IN work_mx2qellqbfbvhd32ao5o5yu3fu 47 32 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 47 33 were be VBD work_mx2qellqbfbvhd32ao5o5yu3fu 47 34 active active JJ work_mx2qellqbfbvhd32ao5o5yu3fu 47 35 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 47 36 multiple multiple JJ work_mx2qellqbfbvhd32ao5o5yu3fu 47 37 tissue tissue NN work_mx2qellqbfbvhd32ao5o5yu3fu 47 38 types type NNS work_mx2qellqbfbvhd32ao5o5yu3fu 47 39 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 48 1 The the DT work_mx2qellqbfbvhd32ao5o5yu3fu 48 2 data datum NNS work_mx2qellqbfbvhd32ao5o5yu3fu 48 3 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 48 4 Stenesen Stenesen NNP work_mx2qellqbfbvhd32ao5o5yu3fu 48 5 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 48 6 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 48 7 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 49 1 show show VB work_mx2qellqbfbvhd32ao5o5yu3fu 49 2 that that IN work_mx2qellqbfbvhd32ao5o5yu3fu 49 3 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 49 4 can can MD work_mx2qellqbfbvhd32ao5o5yu3fu 49 5 promote promote VB work_mx2qellqbfbvhd32ao5o5yu3fu 49 6 healthy healthy JJ work_mx2qellqbfbvhd32ao5o5yu3fu 49 7 aging aging NN work_mx2qellqbfbvhd32ao5o5yu3fu 49 8 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 49 9 Elsevier Elsevier NNP work_mx2qellqbfbvhd32ao5o5yu3fu 49 10 Inc. Inc. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 49 11 organisms organism NNS work_mx2qellqbfbvhd32ao5o5yu3fu 49 12 beyond beyond IN work_mx2qellqbfbvhd32ao5o5yu3fu 49 13 C. C. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 49 14 elegans elegan NNS work_mx2qellqbfbvhd32ao5o5yu3fu 49 15 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 50 1 As as IN work_mx2qellqbfbvhd32ao5o5yu3fu 50 2 such such JJ work_mx2qellqbfbvhd32ao5o5yu3fu 50 3 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 50 4 they -PRON- PRP work_mx2qellqbfbvhd32ao5o5yu3fu 50 5 add add VBP work_mx2qellqbfbvhd32ao5o5yu3fu 50 6 life life NN work_mx2qellqbfbvhd32ao5o5yu3fu 50 7 span span NN work_mx2qellqbfbvhd32ao5o5yu3fu 50 8 extension extension NN work_mx2qellqbfbvhd32ao5o5yu3fu 50 9 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 50 10 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 50 11 growing grow VBG work_mx2qellqbfbvhd32ao5o5yu3fu 50 12 list list NN work_mx2qellqbfbvhd32ao5o5yu3fu 50 13 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 50 14 conserved conserve VBN work_mx2qellqbfbvhd32ao5o5yu3fu 50 15 physiological physiological JJ work_mx2qellqbfbvhd32ao5o5yu3fu 50 16 effects effect NNS work_mx2qellqbfbvhd32ao5o5yu3fu 50 17 mediated mediate VBN work_mx2qellqbfbvhd32ao5o5yu3fu 50 18 by by IN work_mx2qellqbfbvhd32ao5o5yu3fu 50 19 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 50 20 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 50 21 Hardie Hardie NNP work_mx2qellqbfbvhd32ao5o5yu3fu 50 22 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 50 23 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 50 24 . . NNP work_mx2qellqbfbvhd32ao5o5yu3fu 50 25 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 50 26 2012 2012 CD work_mx2qellqbfbvhd32ao5o5yu3fu 50 27 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 50 28 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 51 1 The the DT work_mx2qellqbfbvhd32ao5o5yu3fu 51 2 role role NN work_mx2qellqbfbvhd32ao5o5yu3fu 51 3 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 51 4 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 51 5 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 51 6 sens- sens- JJ work_mx2qellqbfbvhd32ao5o5yu3fu 51 7 ing ing NN work_mx2qellqbfbvhd32ao5o5yu3fu 51 8 resources resource NNS work_mx2qellqbfbvhd32ao5o5yu3fu 51 9 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 51 10 maintaining maintain VBG work_mx2qellqbfbvhd32ao5o5yu3fu 51 11 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 51 12 balance balance NN work_mx2qellqbfbvhd32ao5o5yu3fu 51 13 is be VBZ work_mx2qellqbfbvhd32ao5o5yu3fu 51 14 conserved conserve VBN work_mx2qellqbfbvhd32ao5o5yu3fu 51 15 from from IN work_mx2qellqbfbvhd32ao5o5yu3fu 51 16 worm worm NN work_mx2qellqbfbvhd32ao5o5yu3fu 51 17 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 51 18 fly fly VB work_mx2qellqbfbvhd32ao5o5yu3fu 51 19 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 51 20 mouse mouse NN work_mx2qellqbfbvhd32ao5o5yu3fu 51 21 to to IN work_mx2qellqbfbvhd32ao5o5yu3fu 51 22 humans human NNS work_mx2qellqbfbvhd32ao5o5yu3fu 51 23 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 52 1 If if IN work_mx2qellqbfbvhd32ao5o5yu3fu 52 2 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 52 3 longevity longevity NN work_mx2qellqbfbvhd32ao5o5yu3fu 52 4 data datum NNS work_mx2qellqbfbvhd32ao5o5yu3fu 52 5 presented present VBN work_mx2qellqbfbvhd32ao5o5yu3fu 52 6 by by IN work_mx2qellqbfbvhd32ao5o5yu3fu 52 7 Stenesen Stenesen NNP work_mx2qellqbfbvhd32ao5o5yu3fu 52 8 et et NNP work_mx2qellqbfbvhd32ao5o5yu3fu 52 9 al al NNP work_mx2qellqbfbvhd32ao5o5yu3fu 52 10 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 53 1 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 53 2 this this DT work_mx2qellqbfbvhd32ao5o5yu3fu 53 3 issue issue NN work_mx2qellqbfbvhd32ao5o5yu3fu 53 4 represent represent VB work_mx2qellqbfbvhd32ao5o5yu3fu 53 5 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 53 6 first first JJ work_mx2qellqbfbvhd32ao5o5yu3fu 53 7 step step NN work_mx2qellqbfbvhd32ao5o5yu3fu 53 8 on on IN work_mx2qellqbfbvhd32ao5o5yu3fu 53 9 a a DT work_mx2qellqbfbvhd32ao5o5yu3fu 53 10 similar similar JJ work_mx2qellqbfbvhd32ao5o5yu3fu 53 11 conservation conservation NN work_mx2qellqbfbvhd32ao5o5yu3fu 53 12 ladder ladder NN work_mx2qellqbfbvhd32ao5o5yu3fu 53 13 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 53 14 targeting target VBG work_mx2qellqbfbvhd32ao5o5yu3fu 53 15 AMPK AMPK NNP work_mx2qellqbfbvhd32ao5o5yu3fu 53 16 to to TO work_mx2qellqbfbvhd32ao5o5yu3fu 53 17 tip tip VB work_mx2qellqbfbvhd32ao5o5yu3fu 53 18 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 53 19 energy energy NN work_mx2qellqbfbvhd32ao5o5yu3fu 53 20 balance balance NN work_mx2qellqbfbvhd32ao5o5yu3fu 53 21 toward toward IN work_mx2qellqbfbvhd32ao5o5yu3fu 53 22 healthy healthy JJ work_mx2qellqbfbvhd32ao5o5yu3fu 53 23 aging aging NN work_mx2qellqbfbvhd32ao5o5yu3fu 53 24 in in IN work_mx2qellqbfbvhd32ao5o5yu3fu 53 25 humans human NNS work_mx2qellqbfbvhd32ao5o5yu3fu 53 26 might may MD work_mx2qellqbfbvhd32ao5o5yu3fu 53 27 provide provide VB work_mx2qellqbfbvhd32ao5o5yu3fu 53 28 protection protection NN work_mx2qellqbfbvhd32ao5o5yu3fu 53 29 against against IN work_mx2qellqbfbvhd32ao5o5yu3fu 53 30 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 53 31 ever ever RB work_mx2qellqbfbvhd32ao5o5yu3fu 53 32 - - HYPH work_mx2qellqbfbvhd32ao5o5yu3fu 53 33 growing grow VBG work_mx2qellqbfbvhd32ao5o5yu3fu 53 34 burden burden NN work_mx2qellqbfbvhd32ao5o5yu3fu 53 35 of of IN work_mx2qellqbfbvhd32ao5o5yu3fu 53 36 age- age- RB work_mx2qellqbfbvhd32ao5o5yu3fu 53 37 related related JJ work_mx2qellqbfbvhd32ao5o5yu3fu 53 38 pathologies pathology NNS work_mx2qellqbfbvhd32ao5o5yu3fu 53 39 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 54 1 REFERENCES REFERENCES NNP work_mx2qellqbfbvhd32ao5o5yu3fu 54 2 Apfeld Apfeld NNP work_mx2qellqbfbvhd32ao5o5yu3fu 54 3 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 54 4 J. J. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 54 5 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 54 6 O’Connor O’Connor NNP work_mx2qellqbfbvhd32ao5o5yu3fu 54 7 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 54 8 G. G. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 54 9 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 54 10 McDonagh McDonagh NNP work_mx2qellqbfbvhd32ao5o5yu3fu 54 11 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 54 12 T. T. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 54 13 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 54 14 DiSte- DiSte- NNP work_mx2qellqbfbvhd32ao5o5yu3fu 54 15 fano fano NN work_mx2qellqbfbvhd32ao5o5yu3fu 54 16 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 54 17 P.S. P.S. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 54 18 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 54 19 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 54 20 Curtis Curtis NNP work_mx2qellqbfbvhd32ao5o5yu3fu 54 21 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 54 22 R. R. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 54 23 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 54 24 2004 2004 CD work_mx2qellqbfbvhd32ao5o5yu3fu 54 25 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 54 26 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 55 1 Genes Genes NNP work_mx2qellqbfbvhd32ao5o5yu3fu 55 2 Dev Dev NNP work_mx2qellqbfbvhd32ao5o5yu3fu 55 3 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 56 1 18 18 CD work_mx2qellqbfbvhd32ao5o5yu3fu 56 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 56 3 3004–3009 3004–3009 CD work_mx2qellqbfbvhd32ao5o5yu3fu 56 4 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 57 1 Fontana Fontana NNP work_mx2qellqbfbvhd32ao5o5yu3fu 57 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 57 3 L. L. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 57 4 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 57 5 Partridge Partridge NNP work_mx2qellqbfbvhd32ao5o5yu3fu 57 6 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 57 7 L. L. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 57 8 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 57 9 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 57 10 Longo Longo NNP work_mx2qellqbfbvhd32ao5o5yu3fu 57 11 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 57 12 V.D. V.D. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 58 1 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 58 2 2010 2010 CD work_mx2qellqbfbvhd32ao5o5yu3fu 58 3 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 58 4 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 59 1 Science science NN work_mx2qellqbfbvhd32ao5o5yu3fu 59 2 328 328 CD work_mx2qellqbfbvhd32ao5o5yu3fu 59 3 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 59 4 321–326 321–326 CD work_mx2qellqbfbvhd32ao5o5yu3fu 59 5 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 60 1 Greer Greer NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 3 E.L. E.L. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 4 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 5 Dowlatshahi Dowlatshahi NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 6 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 7 D. D. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 8 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 9 Banko Banko NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 10 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 11 M.R. M.R. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 12 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 13 Villen Villen NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 14 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 15 J. J. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 16 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 17 Hoang Hoang NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 18 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 19 K. K. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 20 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 21 Blanchard Blanchard NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 22 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 23 D. D. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 24 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 25 Gygi Gygi NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 26 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 27 S.P. S.P. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 28 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 29 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 60 30 Brunet Brunet NNP work_mx2qellqbfbvhd32ao5o5yu3fu 60 31 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 60 32 A. a. NN work_mx2qellqbfbvhd32ao5o5yu3fu 61 1 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 61 2 2007 2007 CD work_mx2qellqbfbvhd32ao5o5yu3fu 61 3 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 61 4 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 62 1 Curr curr UH work_mx2qellqbfbvhd32ao5o5yu3fu 62 2 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 63 1 Biol Biol NNP work_mx2qellqbfbvhd32ao5o5yu3fu 63 2 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 64 1 17 17 CD work_mx2qellqbfbvhd32ao5o5yu3fu 64 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 64 3 1646–1656 1646–1656 CD work_mx2qellqbfbvhd32ao5o5yu3fu 64 4 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 65 1 Hardie Hardie NNP work_mx2qellqbfbvhd32ao5o5yu3fu 65 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 65 3 D.G. D.G. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 65 4 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 65 5 Ross Ross NNP work_mx2qellqbfbvhd32ao5o5yu3fu 65 6 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 65 7 F.A. F.A. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 65 8 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 65 9 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 65 10 Hawley Hawley NNP work_mx2qellqbfbvhd32ao5o5yu3fu 65 11 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 65 12 S.A. S.A. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 65 13 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 65 14 2012 2012 CD work_mx2qellqbfbvhd32ao5o5yu3fu 65 15 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 65 16 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 66 1 Nat Nat NNP work_mx2qellqbfbvhd32ao5o5yu3fu 66 2 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 67 1 Rev. Rev. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 68 1 Mol Mol NNP work_mx2qellqbfbvhd32ao5o5yu3fu 68 2 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 69 1 Cell Cell NNP work_mx2qellqbfbvhd32ao5o5yu3fu 69 2 Biol Biol NNP work_mx2qellqbfbvhd32ao5o5yu3fu 69 3 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 70 1 13 13 CD work_mx2qellqbfbvhd32ao5o5yu3fu 70 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 70 3 251–262 251–262 CD work_mx2qellqbfbvhd32ao5o5yu3fu 70 4 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 71 1 Mair Mair NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 3 W. W. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 4 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 5 Morantte Morantte NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 6 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 7 I. I. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 8 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 9 Rodrigues Rodrigues NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 10 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 11 A.P.C. A.P.C. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 12 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 13 Manning Manning NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 14 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 15 G. G. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 16 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 17 Montminy Montminy NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 18 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 19 M. M. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 20 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 21 Shaw Shaw NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 22 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 23 R.J. R.J. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 24 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 25 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 71 26 Dillin Dillin NNP work_mx2qellqbfbvhd32ao5o5yu3fu 71 27 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 71 28 A. a. NN work_mx2qellqbfbvhd32ao5o5yu3fu 72 1 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 72 2 2011 2011 CD work_mx2qellqbfbvhd32ao5o5yu3fu 72 3 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 72 4 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 73 1 Nature nature NN work_mx2qellqbfbvhd32ao5o5yu3fu 73 2 470 470 CD work_mx2qellqbfbvhd32ao5o5yu3fu 73 3 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 73 4 404–408 404–408 CD work_mx2qellqbfbvhd32ao5o5yu3fu 73 5 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 74 1 Onken Onken NNP work_mx2qellqbfbvhd32ao5o5yu3fu 74 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 74 3 B. B. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 74 4 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 74 5 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 74 6 Driscoll Driscoll NNP work_mx2qellqbfbvhd32ao5o5yu3fu 74 7 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 74 8 M. M. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 74 9 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 74 10 2010 2010 CD work_mx2qellqbfbvhd32ao5o5yu3fu 74 11 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 74 12 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 75 1 PLoS PLoS NNP work_mx2qellqbfbvhd32ao5o5yu3fu 75 2 ONE one CD work_mx2qellqbfbvhd32ao5o5yu3fu 75 3 5 5 CD work_mx2qellqbfbvhd32ao5o5yu3fu 75 4 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 75 5 e8758 e8758 NNP work_mx2qellqbfbvhd32ao5o5yu3fu 75 6 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 76 1 Slack Slack NNP work_mx2qellqbfbvhd32ao5o5yu3fu 76 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 76 3 C. C. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 76 4 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 76 5 Foley Foley NNP work_mx2qellqbfbvhd32ao5o5yu3fu 76 6 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 76 7 A. a. NN work_mx2qellqbfbvhd32ao5o5yu3fu 76 8 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 76 9 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 76 10 Partridge Partridge NNP work_mx2qellqbfbvhd32ao5o5yu3fu 76 11 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 76 12 L. L. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 76 13 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 76 14 2012 2012 CD work_mx2qellqbfbvhd32ao5o5yu3fu 76 15 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 76 16 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 77 1 PLoS PLoS NNP work_mx2qellqbfbvhd32ao5o5yu3fu 77 2 ONE one CD work_mx2qellqbfbvhd32ao5o5yu3fu 77 3 7 7 CD work_mx2qellqbfbvhd32ao5o5yu3fu 77 4 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 77 5 e47699 e47699 NNP work_mx2qellqbfbvhd32ao5o5yu3fu 77 6 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 78 1 Steinberg Steinberg NNP work_mx2qellqbfbvhd32ao5o5yu3fu 78 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 78 3 G.R. G.R. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 78 4 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 78 5 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 78 6 Kemp Kemp NNP work_mx2qellqbfbvhd32ao5o5yu3fu 78 7 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 78 8 B.E. B.E. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 79 1 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 79 2 2009 2009 CD work_mx2qellqbfbvhd32ao5o5yu3fu 79 3 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 79 4 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 80 1 Physiol Physiol NNP work_mx2qellqbfbvhd32ao5o5yu3fu 80 2 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 81 1 Rev. Rev. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 82 1 89 89 CD work_mx2qellqbfbvhd32ao5o5yu3fu 82 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 82 3 1025–1078 1025–1078 CD work_mx2qellqbfbvhd32ao5o5yu3fu 82 4 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 83 1 Stenesen Stenesen NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 3 D. D. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 4 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 5 Suh Suh NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 6 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 7 J.M. J.M. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 8 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 9 Seo Seo NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 10 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 11 J. J. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 12 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 13 Yu Yu NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 14 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 15 K. K. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 16 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 17 Lee Lee NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 18 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 19 K.-S. K.-S. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 20 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 21 Kim Kim NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 22 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 23 J.-S. J.-S. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 24 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 25 Min Min NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 26 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 27 K.-J. K.-J. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 28 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 29 and and CC work_mx2qellqbfbvhd32ao5o5yu3fu 83 30 Graff Graff NNP work_mx2qellqbfbvhd32ao5o5yu3fu 83 31 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 83 32 J.M. J.M. NNP work_mx2qellqbfbvhd32ao5o5yu3fu 84 1 ( ( -LRB- work_mx2qellqbfbvhd32ao5o5yu3fu 84 2 2012 2012 CD work_mx2qellqbfbvhd32ao5o5yu3fu 84 3 ) ) -RRB- work_mx2qellqbfbvhd32ao5o5yu3fu 84 4 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 85 1 Cell Cell NNP work_mx2qellqbfbvhd32ao5o5yu3fu 85 2 Metab Metab NNP work_mx2qellqbfbvhd32ao5o5yu3fu 85 3 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 86 1 17 17 CD work_mx2qellqbfbvhd32ao5o5yu3fu 86 2 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 86 3 this this DT work_mx2qellqbfbvhd32ao5o5yu3fu 86 4 issue issue NN work_mx2qellqbfbvhd32ao5o5yu3fu 86 5 , , , work_mx2qellqbfbvhd32ao5o5yu3fu 86 6 101–112 101–112 CD work_mx2qellqbfbvhd32ao5o5yu3fu 86 7 . . . work_mx2qellqbfbvhd32ao5o5yu3fu 87 1 Tipping tip VBG work_mx2qellqbfbvhd32ao5o5yu3fu 87 2 the the DT work_mx2qellqbfbvhd32ao5o5yu3fu 87 3 Energy Energy NNP work_mx2qellqbfbvhd32ao5o5yu3fu 87 4 Balance Balance NNP work_mx2qellqbfbvhd32ao5o5yu3fu 87 5 toward toward IN work_mx2qellqbfbvhd32ao5o5yu3fu 87 6 Longevity Longevity NNP work_mx2qellqbfbvhd32ao5o5yu3fu 87 7 References reference NNS