id sid tid token lemma pos work_zbi2knhp65ho5n7vbsuthmd7gi 1 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 1 2 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 3 amodiaquine amodiaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 4 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 1 5 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 6 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 1 7 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 8 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 1 9 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 10 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 11 sensitizing sensitize VBG work_zbi2knhp65ho5n7vbsuthmd7gi 1 12 huma huma NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 13 Full Full NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 14 Terms Terms NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 1 15 & & CC work_zbi2knhp65ho5n7vbsuthmd7gi 1 16 Conditions Conditions NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 1 17 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 1 18 access access NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 19 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 1 20 use use NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 21 can can MD work_zbi2knhp65ho5n7vbsuthmd7gi 1 22 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 1 23 found find VBN work_zbi2knhp65ho5n7vbsuthmd7gi 1 24 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 1 25 https://www.tandfonline.com/action/journalInformation?journalCode=kaup20 https://www.tandfonline.com/action/journalInformation?journalCode=kaup20 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 26 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 27 ISSN ISSN NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 28 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 1 29 1554 1554 CD work_zbi2knhp65ho5n7vbsuthmd7gi 1 30 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 1 31 8627 8627 CD work_zbi2knhp65ho5n7vbsuthmd7gi 1 32 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 1 33 Print print NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 34 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 1 35 1554 1554 CD work_zbi2knhp65ho5n7vbsuthmd7gi 1 36 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 1 37 8635 8635 CD work_zbi2knhp65ho5n7vbsuthmd7gi 1 38 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 1 39 Online Online NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 40 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 1 41 Journal Journal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 42 homepage homepage NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 43 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 1 44 https://www.tandfonline.com/loi/kaup20 https://www.tandfonline.com/loi/kaup20 VB work_zbi2knhp65ho5n7vbsuthmd7gi 1 45 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 1 46 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 47 amodiaquine amodiaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 48 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 1 49 autophagic- autophagic- NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 50 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 51 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 1 52 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 53 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 54 sensitizing sensitize VBG work_zbi2knhp65ho5n7vbsuthmd7gi 1 55 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 56 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 57 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 1 58 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 1 59 starvation- starvation- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 60 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 1 61 chemotherapy chemotherapy NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 62 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 1 63 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 1 64 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 65 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 66 Shuxi Shuxi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 67 Qiao Qiao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 68 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 69 Shasha Shasha NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 70 Tao Tao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 71 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 72 Montserrat Montserrat NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 73 Rojo Rojo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 74 de de NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 75 la la NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 76 Vega Vega NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 77 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 78 Sophia Sophia NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 79 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 80 Park Park NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 81 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 82 Amanda Amanda NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 83 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 84 Vonderfecht Vonderfecht NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 85 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 86 Suesan Suesan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 87 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 88 Jacobs Jacobs NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 89 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 90 Donna Donna NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 91 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 92 Zhang Zhang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 93 & & CC work_zbi2knhp65ho5n7vbsuthmd7gi 1 94 Georg Georg NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 95 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 96 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 97 To to TO work_zbi2knhp65ho5n7vbsuthmd7gi 1 98 cite cite VB work_zbi2knhp65ho5n7vbsuthmd7gi 1 99 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 1 100 article article NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 101 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 1 102 Shuxi Shuxi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 103 Qiao Qiao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 104 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 105 Shasha Shasha NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 106 Tao Tao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 107 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 108 Montserrat Montserrat NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 109 Rojo Rojo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 110 de de NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 111 la la NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 112 Vega Vega NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 113 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 114 Sophia Sophia NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 115 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 116 Park Park NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 117 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 118 Amanda Amanda NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 119 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 120 Vonderfecht Vonderfecht NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 121 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 122 Suesan Suesan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 123 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 124 Jacobs Jacobs NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 125 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 126 Donna Donna NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 127 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 128 Zhang Zhang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 129 & & CC work_zbi2knhp65ho5n7vbsuthmd7gi 1 130 Georg Georg NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 131 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 132 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 133 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 1 134 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 1 135 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 1 136 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 1 137 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 138 amodiaquine amodiaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 139 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 1 140 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 141 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 1 142 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 143 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 1 144 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 145 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 146 sensitizing sensitize VBG work_zbi2knhp65ho5n7vbsuthmd7gi 1 147 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 148 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 149 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 1 150 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 1 151 starvation- starvation- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 152 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 1 153 chemotherapy chemotherapy NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 154 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 1 155 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 1 156 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 157 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 158 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 159 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 160 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 161 9:12 9:12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 1 162 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 163 2087 2087 CD work_zbi2knhp65ho5n7vbsuthmd7gi 1 164 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 1 165 2102 2102 CD work_zbi2knhp65ho5n7vbsuthmd7gi 1 166 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 1 167 DOI doi NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 168 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 1 169 10.4161 10.4161 CD work_zbi2knhp65ho5n7vbsuthmd7gi 1 170 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 1 171 auto.26506 auto.26506 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 1 172 To to TO work_zbi2knhp65ho5n7vbsuthmd7gi 1 173 link link VB work_zbi2knhp65ho5n7vbsuthmd7gi 1 174 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 1 175 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 1 176 article article NN work_zbi2knhp65ho5n7vbsuthmd7gi 1 177 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 1 178 https://doi.org/10.4161/auto.26506 https://doi.org/10.4161/auto.26506 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 179 Published publish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 1 180 online online RB work_zbi2knhp65ho5n7vbsuthmd7gi 1 181 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 1 182 08 08 CD work_zbi2knhp65ho5n7vbsuthmd7gi 1 183 Oct Oct NNP work_zbi2knhp65ho5n7vbsuthmd7gi 1 184 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 1 185 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 2 1 Submit submit VB work_zbi2knhp65ho5n7vbsuthmd7gi 2 2 your -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 2 3 article article NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 4 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 5 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 2 6 journal journal NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 7 Article article NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 8 views view VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 2 9 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 2 10 1163 1163 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 11 View View NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 12 related related JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 13 articles article NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 14 Citing cite VBG work_zbi2knhp65ho5n7vbsuthmd7gi 2 15 articles article NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 16 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 2 17 17 17 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 18 View View NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 19 citing cite VBG work_zbi2knhp65ho5n7vbsuthmd7gi 2 20 articles article NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 21 https://www.tandfonline.com/action/journalInformation?journalCode=kaup20 https://www.tandfonline.com/action/journalinformation?journalcode=kaup20 NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 22 https://www.tandfonline.com/loi/kaup20 https://www.tandfonline.com/loi/kaup20 NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 23 https://www.tandfonline.com/action/showCitFormats?doi=10.4161/auto.26506 https://www.tandfonline.com/action/showcitformats?doi=10.4161/auto.26506 NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 24 https://doi.org/10.4161/auto.26506 https://doi.org/10.4161/auto.26506 VB work_zbi2knhp65ho5n7vbsuthmd7gi 2 25 https://www.tandfonline.com/action/authorSubmission?journalCode=kaup20&show=instructions https://www.tandfonline.com/action/authorsubmission?journalcode=kaup20&show=instruction NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 26 https://www.tandfonline.com/action/authorSubmission?journalCode=kaup20&show=instructions https://www.tandfonline.com/action/authorsubmission?journalcode=kaup20&show=instruction NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 27 https://www.tandfonline.com/doi/mlt/10.4161/auto.26506 https://www.tandfonline.com/doi/mlt/10.4161/auto.26506 NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 28 https://www.tandfonline.com/doi/mlt/10.4161/auto.26506 https://www.tandfonline.com/doi/mlt/10.4161/auto.26506 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 29 https://www.tandfonline.com/doi/citedby/10.4161/auto.26506#tabModule https://www.tandfonline.com/doi/citedby/10.4161/auto.26506#tabModule NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 30 https://www.tandfonline.com/doi/citedby/10.4161/auto.26506#tabModule https://www.tandfonline.com/doi/citedby/10.4161/auto.26506#tabModule NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 31 © © NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 32 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 33 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 34 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 35 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 2 36 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 37 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 38 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 39 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 2 40 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 2 41 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 42 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 2 43 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 44 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 45 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 46 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 2 47 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 48 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 49 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 2 50 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 51 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 52 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 2 53 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 54 Basic Basic NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 55 ReseaRch ReseaRch NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 56 PaPeR PaPeR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 57 www.landesbioscience.com www.landesbioscience.com NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 58 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 59 2087 2087 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 60 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 61 9:12 9:12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 62 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 63 2087–2102 2087–2102 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 64 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 65 December December NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 66 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 67 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 68 © © LS work_zbi2knhp65ho5n7vbsuthmd7gi 2 69 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 70 Landes Landes NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 2 71 Bioscience Bioscience NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 72 Basic Basic NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 73 ReseaRch ReseaRch NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 74 PaPeR PaPeR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 75 Introduction Introduction NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 76 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 77 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 2 78 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 2 79 evolutionarily evolutionarily RB work_zbi2knhp65ho5n7vbsuthmd7gi 2 80 conserved conserve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 2 81 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 82 intracellular intracellular NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 83 cata- cata- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 84 bolic bolic NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 85 pathway pathway NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 86 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 2 87 serves serve VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 2 88 survival survival NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 89 functions function NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 90 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 91 maintaining maintain VBG work_zbi2knhp65ho5n7vbsuthmd7gi 2 92 cellular cellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 93 homeostasis homeostasis NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 94 under under IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 95 adverse adverse JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 96 conditions condition NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 97 such such JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 98 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 99 nutrient nutrient NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 100 deprivation deprivation NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 101 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 2 102 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 103 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 104 misfolded misfolded JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 105 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 106 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 2 107 damaged damage VBD work_zbi2knhp65ho5n7vbsuthmd7gi 2 108 organelles.1 organelles.1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 109 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 2 110 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 111 Dysregulation Dysregulation NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 112 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 113 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 114 has have VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 2 115 been be VBN work_zbi2knhp65ho5n7vbsuthmd7gi 2 116 implicated implicate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 2 117 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 118 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 2 119 broad broad JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 120 range range NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 121 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 122 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 123 pathologies pathology NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 124 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 2 125 neurodegeneration neurodegeneration NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 126 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 2 127 cancer,4,5 cancer,4,5 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 128 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 2 129 pathological pathological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 130 alterations alteration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 131 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 132 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 133 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 2 134 lyso- lyso- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 135 somal somal NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 136 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 137 can can MD work_zbi2knhp65ho5n7vbsuthmd7gi 2 138 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 2 139 occur occur VB work_zbi2knhp65ho5n7vbsuthmd7gi 2 140 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 141 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 142 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 143 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 144 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 145 environ- environ- NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 146 mental mental JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 147 toxicants toxicant NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 148 such such JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 149 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 150 arsenic arsenic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 151 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 2 152 solar solar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 153 UV uv NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 154 radiation.6 radiation.6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 155 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 2 156 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 157 Recent recent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 158 evidence evidence NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 159 suggests suggest VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 2 160 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 161 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 162 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 163 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 2 164 harness harness VB work_zbi2knhp65ho5n7vbsuthmd7gi 2 165 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 166 path- path- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 167 ways way NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 168 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 169 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 2 170 adaptation adaptation NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 171 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 172 conditions condition NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 173 associated associate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 2 174 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 175 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 2 176 tumor tumor NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 177 microenvironment microenvironment NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 178 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 2 179 increased increase VBN work_zbi2knhp65ho5n7vbsuthmd7gi 2 180 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 181 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 182 oxidative oxidative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 183 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 2 184 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 2 185 Correspondence correspondence NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 186 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 187 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 2 188 Georg Georg NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 189 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 190 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 191 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 192 Email email NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 193 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 2 194 wondrak@pharmacy.arizona.edu wondrak@pharmacy.arizona.edu NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 195 Submitted submit VBN work_zbi2knhp65ho5n7vbsuthmd7gi 2 196 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 2 197 05/17/2013 05/17/2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 198 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 199 Revised revise VBN work_zbi2knhp65ho5n7vbsuthmd7gi 2 200 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 2 201 09/09/2013 09/09/2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 202 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 203 Accepted accepted JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 204 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 2 205 09/16/2013 09/16/2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 206 http://dx.doi.org/10.4161/auto.26506 http://dx.doi.org/10.4161/auto.26506 NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 207 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 2 208 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 209 amodiaquine amodiaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 210 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 2 211 autophagic- autophagic- NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 212 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 213 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 2 214 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 215 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 216 sensitizing sensitize VBG work_zbi2knhp65ho5n7vbsuthmd7gi 2 217 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 218 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 219 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 220 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 221 starvation- starvation- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 222 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 2 223 chemotherapy chemotherapy NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 224 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 2 225 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 2 226 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 227 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 228 shuxi shuxi NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 229 Qiao Qiao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 230 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 231 shasha shasha NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 232 Tao Tao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 233 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 234 Montserrat Montserrat NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 235 Rojo Rojo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 236 de de NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 237 la la NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 238 Vega Vega NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 239 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 240 sophia sophia NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 241 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 242 Park Park NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 243 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 244 amanda amanda VB work_zbi2knhp65ho5n7vbsuthmd7gi 2 245 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 2 246 Vonderfecht Vonderfecht NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 247 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 248 suesan suesan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 249 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 250 Jacobs Jacobs NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 251 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 252 Donna Donna NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 253 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 254 Zhang Zhang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 255 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 256 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 2 257 Georg Georg NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 258 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 259 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 260 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 2 261 Department Department NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 262 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 263 Pharmacology Pharmacology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 264 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 2 265 Toxicology Toxicology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 266 ; ; , work_zbi2knhp65ho5n7vbsuthmd7gi 2 267 college college NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 268 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 269 Pharmacy Pharmacy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 270 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 2 271 arizona arizona NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 272 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 273 center center NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 274 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 275 University University NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 276 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 277 arizona arizona NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 278 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 279 Tucson Tucson NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 280 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 281 aZ aZ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 282 Usa Usa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 283 Keywords Keywords NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 284 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 2 285 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 286 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 287 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 288 amodiaquine amodiaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 289 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 290 chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 291 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 292 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 293 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 294 lysosome lysosome NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 295 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 296 cathepsin cathepsin NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 297 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 298 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 299 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 300 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 301 Abbreviations Abbreviations NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 2 302 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 2 303 ACTB ACTB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 304 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 305 actin actin NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 306 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 307 beta beta NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 308 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 309 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 310 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 311 amodiaquine amodiaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 312 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 313 ANX ANX NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 314 A5 A5 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 315 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 316 annexin annexin NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 317 AV av NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 318 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 319 BafA BafA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 320 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 321 bafilomycin bafilomycin VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 2 322 A a DT work_zbi2knhp65ho5n7vbsuthmd7gi 2 323 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 324 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 325 BECN1 BECN1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 326 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 327 Beclin Beclin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 328 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 329 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 330 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 331 related related JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 332 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 333 CCND1 ccnd1 NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 334 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 335 cyclin cyclin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 336 D1 D1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 337 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 338 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 339 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 340 cyclin cyclin NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 341 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 2 342 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 343 kinase kinase NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 344 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 345 1A 1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 346 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 2 347 p21 p21 NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 348 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 349 Cip1 Cip1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 350 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 2 351 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 352 CDDP CDDP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 353 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 354 cis- cis- CC work_zbi2knhp65ho5n7vbsuthmd7gi 2 355 dichloro dichloro NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 356 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 2 357 diamine diamine NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 358 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 2 359 platinum platinum NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 360 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 2 361 II II NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 362 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 2 363 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 364 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 365 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 366 chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 367 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 368 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 369 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 370 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 371 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 372 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 373 CTSD CTSD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 374 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 375 cathepsin cathepsin NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 376 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 377 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 378 CTSL CTSL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 379 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 380 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 381 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 382 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 383 DDIT3 DDIT3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 384 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 385 DNA dna NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 386 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 2 387 damage damage NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 388 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 2 389 inducible inducible JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 390 transcript transcript NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 391 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 392 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 393 Doxo Doxo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 394 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 395 doxorubicin doxorubicin NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 396 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 397 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 398 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 399 E2F E2F NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 400 transcription transcription NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 401 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 402 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 403 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 404 EGR1 EGR1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 405 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 406 early early JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 407 growth growth NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 408 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 409 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 410 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 411 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 412 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 413 green green JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 414 fluorescent fluorescent NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 415 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 416 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 417 HBSS HBSS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 418 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 419 Hank Hank NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 420 ’s ’s POS work_zbi2knhp65ho5n7vbsuthmd7gi 2 421 Balanced Balanced NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 422 Salt Salt NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 423 Solution Solution NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 424 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 425 HSPA1A hspa1a UH work_zbi2knhp65ho5n7vbsuthmd7gi 2 426 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 427 heat heat NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 428 shock shock NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 429 70 70 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 430 kDa kDa NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 431 pro- pro- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 432 tein tein NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 433 1A 1a LS work_zbi2knhp65ho5n7vbsuthmd7gi 2 434 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 435 JC-1 JC-1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 436 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 437 5,5́ 5,5́ CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 438 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 439 6,6́ 6,6́ CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 440 -tetrachloro-1,1́ -tetrachloro-1,1́ NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 441 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 442 3,3 3,3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 443 -́tetraethylbenzimidazolyl -́tetraethylbenzimidazolyl IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 444 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 2 445 carbocyanine carbocyanine NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 446 iodide iodide NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 447 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 448 LAMP1 LAMP1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 449 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 450 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 451 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 2 452 asso- asso- NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 453 ciated ciate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 2 454 membrane membrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 455 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 456 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 457 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 458 PI pi NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 459 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 460 propidium propidium NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 461 iodide iodide NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 462 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 463 RB1 RB1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 464 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 465 retinoblastoma retinoblastoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 466 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 467 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 468 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 469 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 470 red red JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 471 fluorescent fluorescent NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 472 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 473 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 474 SDS SDS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 475 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 2 476 PAGE PAGE NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 477 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 478 sodium sodium NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 479 dodecyl dodecyl JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 480 sulfate sulfate NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 481 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 2 482 polyacrylamide polyacrylamide NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 483 gel gel NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 484 electrophoresis electrophoresis NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 485 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 486 SNCA SNCA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 487 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 488 synuclein synuclein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 489 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 490 alpha alpha NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 491 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 2 492 non non AFX work_zbi2knhp65ho5n7vbsuthmd7gi 2 493 A4 A4 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 494 component component NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 495 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 496 amyloid amyloid NNP work_zbi2knhp65ho5n7vbsuthmd7gi 2 497 precursor precursor NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 498 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 2 499 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 500 SQSTM1 SQSTM1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 501 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 502 sequestosome sequestosome VB work_zbi2knhp65ho5n7vbsuthmd7gi 2 503 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 504 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 2 505 p62 p62 NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 506 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 507 TEM tem NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 508 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 509 transmission transmission NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 510 electron electron NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 511 microscopy microscopy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 512 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 2 513 TP53 tp53 IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 514 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 2 515 tumor tumor NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 516 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 517 53 53 CD work_zbi2knhp65ho5n7vbsuthmd7gi 2 518 Pharmacological pharmacological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 519 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 520 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 521 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 522 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 2 523 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 524 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 525 has have VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 2 526 recently recently RB work_zbi2knhp65ho5n7vbsuthmd7gi 2 527 emerged emerge VBN work_zbi2knhp65ho5n7vbsuthmd7gi 2 528 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 529 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 2 530 promising promising JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 531 strategy strategy NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 532 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 2 533 che- che- DT work_zbi2knhp65ho5n7vbsuthmd7gi 2 534 motherapeutic motherapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 2 535 intervention intervention NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 536 targeting target VBG work_zbi2knhp65ho5n7vbsuthmd7gi 2 537 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 2 538 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 2 539 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 3 1 Repurposing repurpose VBG work_zbi2knhp65ho5n7vbsuthmd7gi 3 2 approved approve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 3 3 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 3 4 abandoned abandon VBD work_zbi2knhp65ho5n7vbsuthmd7gi 3 5 non non JJ work_zbi2knhp65ho5n7vbsuthmd7gi 3 6 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 3 7 oncological oncological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 3 8 drugs drug NNS work_zbi2knhp65ho5n7vbsuthmd7gi 3 9 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 3 10 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 3 11 alternative alternative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 3 12 approach approach NN work_zbi2knhp65ho5n7vbsuthmd7gi 3 13 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 3 14 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 3 15 identification identification NN work_zbi2knhp65ho5n7vbsuthmd7gi 3 16 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 3 17 development development NN work_zbi2knhp65ho5n7vbsuthmd7gi 3 18 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 3 19 anticancer anticancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 3 20 therapeutics therapeutic NNS work_zbi2knhp65ho5n7vbsuthmd7gi 3 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 3 22 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 3 23 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 3 24 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 3 25 target target VBP work_zbi2knhp65ho5n7vbsuthmd7gi 3 26 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 3 27 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 3 28 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 3 29 functions function NNS work_zbi2knhp65ho5n7vbsuthmd7gi 3 30 have have VBP work_zbi2knhp65ho5n7vbsuthmd7gi 3 31 recently recently RB work_zbi2knhp65ho5n7vbsuthmd7gi 3 32 attracted attract VBN work_zbi2knhp65ho5n7vbsuthmd7gi 3 33 considerable considerable JJ work_zbi2knhp65ho5n7vbsuthmd7gi 3 34 attention attention NN work_zbi2knhp65ho5n7vbsuthmd7gi 3 35 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 3 36 candidates candidate NNS work_zbi2knhp65ho5n7vbsuthmd7gi 3 37 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 3 38 oncological oncological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 3 39 repurpos- repurpos- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 3 40 ing ing NNP work_zbi2knhp65ho5n7vbsuthmd7gi 3 41 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 4 1 since since IN work_zbi2knhp65ho5n7vbsuthmd7gi 4 2 cumulative cumulative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 4 3 research research NN work_zbi2knhp65ho5n7vbsuthmd7gi 4 4 suggests suggest VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 4 5 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 4 6 dependence dependence NN work_zbi2knhp65ho5n7vbsuthmd7gi 4 7 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 4 8 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 4 9 represents represent VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 4 10 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 4 11 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 4 12 vulnerability vulnerability NN work_zbi2knhp65ho5n7vbsuthmd7gi 4 13 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 4 14 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 4 15 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 4 16 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 4 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 4 18 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 4 19 screened screen VBD work_zbi2knhp65ho5n7vbsuthmd7gi 4 20 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 4 21 focused focused JJ work_zbi2knhp65ho5n7vbsuthmd7gi 4 22 compound compound NN work_zbi2knhp65ho5n7vbsuthmd7gi 4 23 library library NN work_zbi2knhp65ho5n7vbsuthmd7gi 4 24 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 4 25 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 4 26 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 4 27 antimelanoma antimelanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 4 28 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 4 29 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 5 1 here here RB work_zbi2knhp65ho5n7vbsuthmd7gi 5 2 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 5 3 report report VBP work_zbi2knhp65ho5n7vbsuthmd7gi 5 4 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 5 5 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 5 6 first first JJ work_zbi2knhp65ho5n7vbsuthmd7gi 5 7 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 5 8 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 5 9 amodiaquine amodiaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 5 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 5 11 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 5 12 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 5 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 5 14 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 5 15 clinical clinical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 5 16 4-aminoquinoline 4-aminoquinoline CD work_zbi2knhp65ho5n7vbsuthmd7gi 5 17 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 5 18 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 5 19 unexplored unexplored JJ work_zbi2knhp65ho5n7vbsuthmd7gi 5 20 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 5 21 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 5 22 directed direct VBN work_zbi2knhp65ho5n7vbsuthmd7gi 5 23 chemo- chemo- NN work_zbi2knhp65ho5n7vbsuthmd7gi 5 24 therapeutic therapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 5 25 potential potential NN work_zbi2knhp65ho5n7vbsuthmd7gi 5 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 5 27 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 5 28 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 5 29 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 5 30 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 5 31 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 5 32 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 5 33 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 5 34 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 5 35 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 5 36 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 5 37 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 5 38 surpasses surpass VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 5 39 that that DT work_zbi2knhp65ho5n7vbsuthmd7gi 5 40 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 5 41 its -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 5 42 parent parent NN work_zbi2knhp65ho5n7vbsuthmd7gi 5 43 compound compound NN work_zbi2knhp65ho5n7vbsuthmd7gi 5 44 chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 5 45 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 6 1 Monitoring monitor VBG work_zbi2knhp65ho5n7vbsuthmd7gi 6 2 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 6 3 established establish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 6 4 set set NN work_zbi2knhp65ho5n7vbsuthmd7gi 6 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 6 6 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 6 7 markers marker NNS work_zbi2knhp65ho5n7vbsuthmd7gi 6 8 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 6 9 LaMP1 LaMP1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 6 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 6 11 Lc3-ii Lc3-ii NNP work_zbi2knhp65ho5n7vbsuthmd7gi 6 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 6 13 sQsTM1 sQsTM1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 6 14 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 6 15 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 6 16 cell cell VB work_zbi2knhp65ho5n7vbsuthmd7gi 6 17 ultrastructural ultrastructural JJ work_zbi2knhp65ho5n7vbsuthmd7gi 6 18 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 6 19 detected detect VBN work_zbi2knhp65ho5n7vbsuthmd7gi 6 20 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 6 21 electron electron NNP work_zbi2knhp65ho5n7vbsuthmd7gi 6 22 microscopy microscopy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 6 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 6 24 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 6 25 observed observe VBD work_zbi2knhp65ho5n7vbsuthmd7gi 6 26 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 6 27 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 6 28 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 6 29 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 6 30 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 6 31 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 6 32 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 6 33 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 6 34 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 6 35 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 6 36 a375 a375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 6 37 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 6 38 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 6 39 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 6 40 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 6 41 finding finding NN work_zbi2knhp65ho5n7vbsuthmd7gi 6 42 substantiated substantiate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 6 43 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 6 44 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 6 45 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 6 46 rapid rapid JJ work_zbi2knhp65ho5n7vbsuthmd7gi 6 47 inactivation inactivation NN work_zbi2knhp65ho5n7vbsuthmd7gi 6 48 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 6 49 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 6 50 cathepsins cathepsin NNS work_zbi2knhp65ho5n7vbsuthmd7gi 6 51 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 6 52 cTsB cTsB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 6 53 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 6 54 cTsL cTsL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 6 55 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 6 56 cTsD cTsD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 6 57 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 6 58 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 7 1 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 7 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 7 3 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 7 4 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 7 5 associated associate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 7 6 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 7 7 early early JJ work_zbi2knhp65ho5n7vbsuthmd7gi 7 8 induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 7 9 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 7 10 energy energy NN work_zbi2knhp65ho5n7vbsuthmd7gi 7 11 crisis crisis NN work_zbi2knhp65ho5n7vbsuthmd7gi 7 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 7 13 aTP aTP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 7 14 depletion depletion NN work_zbi2knhp65ho5n7vbsuthmd7gi 7 15 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 7 16 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 7 17 sensitized sensitize VBD work_zbi2knhp65ho5n7vbsuthmd7gi 7 18 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 7 19 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 7 20 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 7 21 either either DT work_zbi2knhp65ho5n7vbsuthmd7gi 7 22 starvation- starvation- NN work_zbi2knhp65ho5n7vbsuthmd7gi 7 23 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 7 24 chemotherapeutic chemotherapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 7 25 agent agent NN work_zbi2knhp65ho5n7vbsuthmd7gi 7 26 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 7 27 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 7 28 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 7 29 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 7 30 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 8 1 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 8 2 displayed display VBD work_zbi2knhp65ho5n7vbsuthmd7gi 8 3 potent potent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 8 4 anti- anti- NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 5 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 8 6 effects effect NNS work_zbi2knhp65ho5n7vbsuthmd7gi 8 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 8 8 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 8 9 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 10 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 11 array array NNP work_zbi2knhp65ho5n7vbsuthmd7gi 8 12 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 13 revealed reveal VBD work_zbi2knhp65ho5n7vbsuthmd7gi 8 14 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 8 15 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 8 16 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 8 17 mRNa mRNa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 8 18 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 8 19 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 8 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 8 21 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 8 22 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 8 23 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 8 24 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 25 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 26 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 8 27 TP53 tp53 NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 28 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 8 29 cDKN1a cdkn1a NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 30 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 8 31 ccND1 ccND1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 8 32 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 8 33 phospho phospho NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 34 - - : work_zbi2knhp65ho5n7vbsuthmd7gi 8 35 RB1 rb1 NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 36 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 8 37 ser ser NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 38 780]/[ser 780]/[ser NNP work_zbi2knhp65ho5n7vbsuthmd7gi 8 39 807/811 807/811 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 8 40 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 8 41 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 8 42 e2F1 e2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 8 43 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 8 44 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 8 45 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 8 46 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 8 47 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 8 48 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 8 49 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 50 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 8 51 s s NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 52 - - NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 53 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 8 54 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 9 1 Taken take VBN work_zbi2knhp65ho5n7vbsuthmd7gi 9 2 together together RB work_zbi2knhp65ho5n7vbsuthmd7gi 9 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 9 4 our -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 9 5 data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 9 6 suggest suggest VBP work_zbi2knhp65ho5n7vbsuthmd7gi 9 7 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 9 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 9 9 clinical clinical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 9 10 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 9 11 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 9 12 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 9 13 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 9 14 promising promising JJ work_zbi2knhp65ho5n7vbsuthmd7gi 9 15 candidate candidate NN work_zbi2knhp65ho5n7vbsuthmd7gi 9 16 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 9 17 repurposing repurpose VBG work_zbi2knhp65ho5n7vbsuthmd7gi 9 18 efforts effort NNS work_zbi2knhp65ho5n7vbsuthmd7gi 9 19 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 9 20 aim aim VBP work_zbi2knhp65ho5n7vbsuthmd7gi 9 21 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 9 22 targeting target VBG work_zbi2knhp65ho5n7vbsuthmd7gi 9 23 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 9 24 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 9 25 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 9 26 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 9 27 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 9 28 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 9 29 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 9 30 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 9 31 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 9 32 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 9 33 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 9 34 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 10 1 © © LS work_zbi2knhp65ho5n7vbsuthmd7gi 10 2 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 3 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 4 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 5 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 6 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 7 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 8 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 9 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 10 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 11 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 12 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 10 13 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 14 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 15 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 16 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 17 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 18 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 19 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 10 20 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 21 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 22 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 10 23 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 24 2088 2088 CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 25 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 26 Volume Volume NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 27 9 9 CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 28 issue issue NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 29 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 30 proteotoxic proteotoxic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 31 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 32 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 33 hypoxia hypoxia NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 34 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 35 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 36 energy energy NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 37 crisis.5,9,10 crisis.5,9,10 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 38 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 39 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 40 occurs occur VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 10 41 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 42 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 43 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 44 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 45 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 46 major major JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 47 classes class NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 48 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 49 chemo- chemo- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 50 therapeutic therapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 51 agents agent NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 52 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 53 e.g. e.g. RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 54 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 55 cisplatin cisplatin NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 56 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 57 doxorubicin doxorubicin NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 58 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 59 Doxo doxo NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 60 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 61 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 62 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 63 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 64 process process NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 65 thought think VBD work_zbi2knhp65ho5n7vbsuthmd7gi 10 66 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 10 67 contribute contribute VB work_zbi2knhp65ho5n7vbsuthmd7gi 10 68 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 69 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 70 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 71 chemoresistance.5,11,12 chemoresistance.5,11,12 NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 72 Therefore therefore RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 73 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 74 pharmacological pharmacological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 75 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 76 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 77 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 78 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 79 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 80 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 81 has have VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 10 82 recently recently RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 83 emerged emerge VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 84 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 85 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 86 promising promising JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 87 strategy strategy NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 88 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 89 thera- thera- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 90 peutic peutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 91 intervention intervention NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 92 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 10 93 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 10 94 preferentially preferentially RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 95 target target VB work_zbi2knhp65ho5n7vbsuthmd7gi 10 96 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 97 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 98 without without IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 99 compromising compromise VBG work_zbi2knhp65ho5n7vbsuthmd7gi 10 100 viability viability NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 101 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 102 normal normal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 103 cells.4,5,9,13 cells.4,5,9,13 , work_zbi2knhp65ho5n7vbsuthmd7gi 10 104 - - : work_zbi2knhp65ho5n7vbsuthmd7gi 10 105 15 15 CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 106 Repurposing repurposing NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 107 approved approve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 108 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 109 abandoned abandon VBD work_zbi2knhp65ho5n7vbsuthmd7gi 10 110 non non JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 111 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 112 oncological oncological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 113 drugs drug NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 114 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 10 115 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 116 alternative alternative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 117 developmental developmental JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 118 strategy strategy NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 119 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 120 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 121 identification identification NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 122 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 123 anticancer anticancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 124 therapeutics therapeutic NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 125 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 126 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 127 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 128 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 10 129 potentially potentially RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 130 under- under- VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 10 131 mine mine PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 10 132 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 133 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 134 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 135 functions function NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 136 have have VBP work_zbi2knhp65ho5n7vbsuthmd7gi 10 137 recently recently RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 138 attracted attract VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 139 considerable considerable JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 140 attention attention NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 141 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 142 promising promising JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 143 candidates candidate NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 144 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 145 oncologi- oncologi- NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 146 cal cal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 147 repurposing.4,16,17 repurposing.4,16,17 CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 148 Since since IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 149 all all DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 150 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 151 pathways pathway NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 152 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 153 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 10 154 macroautophagy macroautophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 155 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 156 microphagy microphagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 157 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 158 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 159 chaperone chaperone NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 160 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 161 mediated mediate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 162 auto- auto- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 163 phagy phagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 164 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 165 converge converge VB work_zbi2knhp65ho5n7vbsuthmd7gi 10 166 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 167 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 168 fusion fusion NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 169 followed follow VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 170 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 171 enzymatic enzymatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 172 degradation degradation NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 173 irrespective irrespective RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 174 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 175 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 176 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 177 mechanism mechanism NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 178 employed employ VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 179 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 180 cargo cargo NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 181 selection selection NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 182 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 183 trafficking trafficking NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 184 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 185 members member NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 186 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 187 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 188 lysosomotropic lysosomotropic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 189 8-aminoquinoline 8-aminoquinoline CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 190 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 191 e.g. e.g. RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 192 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 193 primaquine primaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 194 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 195 pamaquine pamaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 196 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 197 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 198 4-amino- 4-amino- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 199 quinoline quinoline NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 200 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 201 e.g. e.g. RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 202 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 203 chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 204 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 205 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 206 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 207 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 208 hydroxychloroquine hydroxychloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 209 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 210 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 211 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 212 quinoline quinoline NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 213 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 214 e.g. e.g. RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 215 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 216 mefloquine mefloquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 217 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 218 classes class NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 219 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 220 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 221 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 10 222 disrupt disrupt VBP work_zbi2knhp65ho5n7vbsuthmd7gi 10 223 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 224 pH pH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 225 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 226 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 227 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 228 have have VBP work_zbi2knhp65ho5n7vbsuthmd7gi 10 229 been be VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 230 examined examine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 231 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 232 exper- exper- NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 233 imental imental NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 234 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 235 preclinical preclinical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 236 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 237 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 238 investigational investigational JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 239 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 240 clinical clinical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 241 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 242 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 243 thera- thera- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 244 peutics.4,14,18 peutics.4,14,18 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 245 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 246 23 23 CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 247 Indeed indeed RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 248 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 249 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 250 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 251 hydroxychloroquine hydroxychloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 252 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 10 253 currently currently RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 254 undergoing undergo VBG work_zbi2knhp65ho5n7vbsuthmd7gi 10 255 evaluation evaluation NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 256 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 257 numerous numerous JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 258 oncological oncological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 259 clinical clinical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 260 trials trial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 261 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 10 262 examine examine VBP work_zbi2knhp65ho5n7vbsuthmd7gi 10 263 potentiation potentiation NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 264 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 265 therapeutic therapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 266 efficacy efficacy NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 267 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 268 combining combine VBG work_zbi2knhp65ho5n7vbsuthmd7gi 10 269 cytotoxic cytotoxic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 270 chemotherapeutics chemotherapeutic NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 271 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 272 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 273 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 274 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 275 antago- antago- NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 276 nists.21 nists.21 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 277 However however RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 278 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 279 limited limited JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 280 efficacy efficacy NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 281 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 282 systemic systemic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 283 toxicity toxicity NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 284 associated associate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 285 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 286 these these DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 287 prototype prototype NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 288 agents agent NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 289 create create VBP work_zbi2knhp65ho5n7vbsuthmd7gi 10 290 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 291 urgent urgent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 292 need need NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 293 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 294 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 295 iden- iden- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 296 tification tification NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 297 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 298 development development NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 299 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 300 improved improved JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 301 therapeutics therapeutic NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 302 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 10 303 target target VBP work_zbi2knhp65ho5n7vbsuthmd7gi 10 304 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 305 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 306 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 307 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 308 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 309 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 310 cells.5,9,24 cells.5,9,24 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 311 Melanoma Melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 312 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 10 313 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 314 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 315 melanocyte melanocyte NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 316 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 317 derived derive VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 318 tumor tumor NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 319 caus- caus- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 320 ing e VBG work_zbi2knhp65ho5n7vbsuthmd7gi 10 321 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 322 majority majority NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 323 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 324 deaths death NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 325 attributed attribute VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 326 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 327 skin skin NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 328 cancer.25,26 cancer.25,26 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 329 Despite despite IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 330 recent recent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 331 progress progress NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 332 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 333 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 334 design design NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 335 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 336 targeted target VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 337 therapies therapy NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 338 such such JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 339 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 340 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 341 V600E v600e CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 342 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 343 mutation mutation NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 344 directed direct VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 345 BR BR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 346 AF AF NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 347 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 348 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 349 vemurafenib vemurafenib NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 350 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 351 efficacy efficacy NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 352 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 353 chemotherapeutic chemotherapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 354 intervention intervention NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 355 directed direct VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 356 against against IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 357 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 358 meta- meta- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 359 static static JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 360 stage stage NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 361 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 362 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 363 disease disease NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 364 remains remain VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 10 365 limited limited JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 366 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 367 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 368 identification identification NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 369 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 370 development development NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 371 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 372 improved improved JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 373 molecular molecular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 374 agents agent NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 375 targeting target VBG work_zbi2knhp65ho5n7vbsuthmd7gi 10 376 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 377 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 378 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 379 remain remain VBP work_zbi2knhp65ho5n7vbsuthmd7gi 10 380 important important JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 381 goals goal NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 382 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 383 current current JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 384 research.27 research.27 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 385 Cumulative Cumulative NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 386 evidence evidence NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 387 suggests suggest VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 10 388 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 389 involvement involvement NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 390 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 391 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 392 dysregulation dysregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 393 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 394 melanomagenesis melanomagenesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 395 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 396 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 397 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 398 emerging emerge VBG work_zbi2knhp65ho5n7vbsuthmd7gi 10 399 role role NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 400 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 401 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 402 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 403 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 404 prognostic prognostic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 405 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 406 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 407 therapeutic therapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 408 target target NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 409 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 410 mela- mela- NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 411 noma noma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 412 has have VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 10 413 been be VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 414 substantiated substantiate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 415 recently.15,28 recently.15,28 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 416 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 417 31 31 CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 418 Consistent Consistent NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 419 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 420 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 421 hypothesis hypothesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 422 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 423 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 424 efficacy efficacy NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 425 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 426 cisplatin cisplatin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 427 chemotherapeutic chemotherapeutic NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 428 interven- interven- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 429 tion tion NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 430 targeting targeting NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 431 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 432 can can MD work_zbi2knhp65ho5n7vbsuthmd7gi 10 433 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 10 434 potentiated potentiate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 435 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 436 inhibitors inhibitor NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 437 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 438 auto- auto- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 439 phagy phagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 440 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 441 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 442 leucine leucine VB work_zbi2knhp65ho5n7vbsuthmd7gi 10 443 deprivation deprivation NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 444 combined combine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 445 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 446 pharmacological pharmacological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 447 suppression suppression NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 448 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 449 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 450 shows show VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 10 451 therapeutic therapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 452 efficacy efficacy NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 453 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 454 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 455 murine murine NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 456 xenograft xenograft NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 457 model model NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 458 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 459 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 460 human human NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 461 disease.10,32 disease.10,32 RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 462 Recently recently RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 463 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 464 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 10 465 have have VBP work_zbi2knhp65ho5n7vbsuthmd7gi 10 466 screened screen VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 467 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 468 compound compound NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 469 library library NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 470 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 471 clinical clinical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 472 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 473 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 474 antimelanoma antimelanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 475 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 476 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 10 477 identifying identify VBG work_zbi2knhp65ho5n7vbsuthmd7gi 10 478 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 479 endo- endo- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 480 peroxide peroxide NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 481 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 482 based base VBN work_zbi2knhp65ho5n7vbsuthmd7gi 10 483 redox redox NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 484 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 485 dihydroartemisinin dihydroartemisinin NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 486 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 10 487 other other JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 488 members member NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 489 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 490 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 10 491 artemisinin artemisinin NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 492 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 493 class class NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 494 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 495 potent potent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 10 496 inducers inducer NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 497 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 498 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 499 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 500 apoptosis.33,34 apoptosis.33,34 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 501 As as IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 502 part part NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 503 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 504 our -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 10 505 screening screen VBG work_zbi2knhp65ho5n7vbsuthmd7gi 10 506 efforts effort NNS work_zbi2knhp65ho5n7vbsuthmd7gi 10 507 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 10 508 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 10 509 focused focus VBD work_zbi2knhp65ho5n7vbsuthmd7gi 10 510 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 10 511 amodiaquine amodiaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 512 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 513 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 514 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 10 515 4-[(7-chloroquinolin-4-yl)amino]-2- 4-[(7-chloroquinolin-4-yl)amino]-2- CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 516 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 517 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 10 518 diethylamino)methyl]phenol diethylamino)methyl]phenol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 519 CAS CAS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 520 # # NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 521 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 10 522 86 86 CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 523 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 524 42 42 CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 525 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 10 526 0 0 CD work_zbi2knhp65ho5n7vbsuthmd7gi 10 527 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 10 528 chemical chemical NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 529 struc- struc- XX work_zbi2knhp65ho5n7vbsuthmd7gi 10 530 ture ture NN work_zbi2knhp65ho5n7vbsuthmd7gi 10 531 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 10 532 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 10 533 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 11 1 1A 1a LS work_zbi2knhp65ho5n7vbsuthmd7gi 11 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 11 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 11 4 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 11 5 member member NN work_zbi2knhp65ho5n7vbsuthmd7gi 11 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 11 7 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 11 8 lysosomotropic lysosomotropic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 11 9 4-aminoquinoline 4-aminoquinoline CD work_zbi2knhp65ho5n7vbsuthmd7gi 11 10 class class NN work_zbi2knhp65ho5n7vbsuthmd7gi 11 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 11 12 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 11 13 used use VBN work_zbi2knhp65ho5n7vbsuthmd7gi 11 14 worldwide worldwide RB work_zbi2knhp65ho5n7vbsuthmd7gi 11 15 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 11 16 combination combination NN work_zbi2knhp65ho5n7vbsuthmd7gi 11 17 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 11 18 arte- arte- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 11 19 misinin misinin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 11 20 - - , work_zbi2knhp65ho5n7vbsuthmd7gi 11 21 drugs.35,36 drugs.35,36 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 11 22 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 11 23 displays display VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 11 24 potent potent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 11 25 plasmodium plasmodium NN work_zbi2knhp65ho5n7vbsuthmd7gi 11 26 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 11 27 directed direct VBN work_zbi2knhp65ho5n7vbsuthmd7gi 11 28 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 11 29 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 11 30 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 11 31 surpass surpass VB work_zbi2knhp65ho5n7vbsuthmd7gi 11 32 that that DT work_zbi2knhp65ho5n7vbsuthmd7gi 11 33 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 11 34 its -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 11 35 parent parent NN work_zbi2knhp65ho5n7vbsuthmd7gi 11 36 compound compound NN work_zbi2knhp65ho5n7vbsuthmd7gi 11 37 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 11 38 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 11 39 but but CC work_zbi2knhp65ho5n7vbsuthmd7gi 11 40 its -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 11 41 potential potential JJ work_zbi2knhp65ho5n7vbsuthmd7gi 11 42 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 11 43 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 11 44 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 11 45 directed direct VBN work_zbi2knhp65ho5n7vbsuthmd7gi 11 46 activities activity NNS work_zbi2knhp65ho5n7vbsuthmd7gi 11 47 have have VBP work_zbi2knhp65ho5n7vbsuthmd7gi 11 48 remained remain VBN work_zbi2knhp65ho5n7vbsuthmd7gi 11 49 unexplored unexplored JJ work_zbi2knhp65ho5n7vbsuthmd7gi 11 50 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 12 1 Here here RB work_zbi2knhp65ho5n7vbsuthmd7gi 12 2 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 12 3 report report VBP work_zbi2knhp65ho5n7vbsuthmd7gi 12 4 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 12 5 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 12 6 first first JJ work_zbi2knhp65ho5n7vbsuthmd7gi 12 7 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 12 8 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 12 9 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 12 10 targets target VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 12 11 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 12 12 mela- mela- NN work_zbi2knhp65ho5n7vbsuthmd7gi 12 13 noma noma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 12 14 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 12 15 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 12 16 pronounced pronounce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 12 17 induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 12 18 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 12 19 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 12 20 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 12 21 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 12 22 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 12 23 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 12 24 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 12 25 causing cause VBG work_zbi2knhp65ho5n7vbsuthmd7gi 12 26 sensitization sensitization NN work_zbi2knhp65ho5n7vbsuthmd7gi 12 27 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 12 28 starvation- starvation- NN work_zbi2knhp65ho5n7vbsuthmd7gi 12 29 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 12 30 chemotherapeutic chemotherapeutic RB work_zbi2knhp65ho5n7vbsuthmd7gi 12 31 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 12 32 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 12 33 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 12 34 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 12 35 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 13 1 Results Results NNP work_zbi2knhp65ho5n7vbsuthmd7gi 13 2 Amodiaquine Amodiaquine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 13 3 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 13 4 morphological morphological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 13 5 alterations alteration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 13 6 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 13 7 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 13 8 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 13 9 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 13 10 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 13 11 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 13 12 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 13 13 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 13 14 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 13 15 impairment impairment NN work_zbi2knhp65ho5n7vbsuthmd7gi 13 16 First first RB work_zbi2knhp65ho5n7vbsuthmd7gi 13 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 13 18 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 13 19 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 13 20 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 13 21 morphological morphological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 13 22 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 13 23 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 13 24 examined examine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 13 25 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 13 26 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 13 27 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 13 28 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 13 29 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 13 30 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 13 31 light light NN work_zbi2knhp65ho5n7vbsuthmd7gi 13 32 microscopy microscopy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 13 33 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 13 34 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 13 35 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 14 1 1B 1B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 14 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 14 3 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 14 4 transmission transmission NN work_zbi2knhp65ho5n7vbsuthmd7gi 14 5 electron electron NN work_zbi2knhp65ho5n7vbsuthmd7gi 14 6 microscopy microscopy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 14 7 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 14 8 TEM tem RB work_zbi2knhp65ho5n7vbsuthmd7gi 14 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 14 10 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 14 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 15 1 1C 1C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 15 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 15 3 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 15 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 15 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 16 1 Visualization visualization NN work_zbi2knhp65ho5n7vbsuthmd7gi 16 2 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 16 3 light light NN work_zbi2knhp65ho5n7vbsuthmd7gi 16 4 microscopy microscopy NN work_zbi2knhp65ho5n7vbsuthmd7gi 16 5 revealed reveal VBD work_zbi2knhp65ho5n7vbsuthmd7gi 16 6 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 16 7 distinct distinct JJ work_zbi2knhp65ho5n7vbsuthmd7gi 16 8 accumula- accumula- NN work_zbi2knhp65ho5n7vbsuthmd7gi 16 9 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 16 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 16 11 vacuole vacuole JJ work_zbi2knhp65ho5n7vbsuthmd7gi 16 12 structures structure NNS work_zbi2knhp65ho5n7vbsuthmd7gi 16 13 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 16 14 predominantly predominantly RB work_zbi2knhp65ho5n7vbsuthmd7gi 16 15 perinuclear perinuclear JJ work_zbi2knhp65ho5n7vbsuthmd7gi 16 16 local- local- NN work_zbi2knhp65ho5n7vbsuthmd7gi 16 17 ization ization NN work_zbi2knhp65ho5n7vbsuthmd7gi 16 18 within within IN work_zbi2knhp65ho5n7vbsuthmd7gi 16 19 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 16 20 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 16 21 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 16 22 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 16 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 16 24 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 16 25 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 16 26 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 16 27 untreated untreated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 16 28 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 16 29 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 16 30 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 16 31 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 16 32 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 17 1 1B 1B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 17 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 17 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 18 1 Subsequent subsequent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 18 2 TEM tem NN work_zbi2knhp65ho5n7vbsuthmd7gi 18 3 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 18 4 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 18 5 magnifica- magnifica- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 18 6 tion tion NNP work_zbi2knhp65ho5n7vbsuthmd7gi 18 7 2,650 2,650 CD work_zbi2knhp65ho5n7vbsuthmd7gi 18 8 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 18 9 25,000 25,000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 18 10 fold fold RB work_zbi2knhp65ho5n7vbsuthmd7gi 18 11 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 18 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 18 13 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 18 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 19 1 1C 1C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 19 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 19 3 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 19 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 19 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 19 6 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 19 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 19 8 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 19 9 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 10 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 19 11 indicated indicate VBD work_zbi2knhp65ho5n7vbsuthmd7gi 19 12 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 19 13 pronounced pronounce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 19 14 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 15 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 19 16 large large JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 17 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 19 18 0.5–2 0.5–2 FW work_zbi2knhp65ho5n7vbsuthmd7gi 19 19 µm µm NNP work_zbi2knhp65ho5n7vbsuthmd7gi 19 20 diameter diameter NNP work_zbi2knhp65ho5n7vbsuthmd7gi 19 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 19 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 19 23 multivesicular multivesicular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 24 single single JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 25 membrane membrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 26 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 19 27 enclosed enclose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 19 28 structures structure NNS work_zbi2knhp65ho5n7vbsuthmd7gi 19 29 containing contain VBG work_zbi2knhp65ho5n7vbsuthmd7gi 19 30 electron electron NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 31 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 19 32 dense dense JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 33 osmiophilic osmiophilic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 34 inclusions inclusion NNS work_zbi2knhp65ho5n7vbsuthmd7gi 19 35 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 19 36 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 19 37 observation observation NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 38 indicative indicative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 39 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 19 40 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 41 expansion expansion NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 42 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 19 43 lipofuscin lipofuscin JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 44 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 45 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 19 46 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 19 47 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 19 48 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 19 49 untreated untreated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 50 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 51 cells.7,37,38 cells.7,37,38 '' work_zbi2knhp65ho5n7vbsuthmd7gi 19 52 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 19 53 contrast contrast NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 54 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 19 55 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 19 56 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 57 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 19 58 double double JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 59 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 19 60 membrane membrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 61 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 19 62 enclosed enclose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 19 63 small small JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 64 vesicles vesicle NNS work_zbi2knhp65ho5n7vbsuthmd7gi 19 65 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 19 66 would would MD work_zbi2knhp65ho5n7vbsuthmd7gi 19 67 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 19 68 indicative indicative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 69 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 19 70 increased increase VBN work_zbi2knhp65ho5n7vbsuthmd7gi 19 71 autophagosome autophagosome JJ work_zbi2knhp65ho5n7vbsuthmd7gi 19 72 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 73 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 19 74 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 19 75 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 19 76 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 77 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 19 78 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 19 79 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 19 80 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 20 1 Time- time- NN work_zbi2knhp65ho5n7vbsuthmd7gi 20 2 course course NN work_zbi2knhp65ho5n7vbsuthmd7gi 20 3 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 20 4 demonstrated demonstrate VBD work_zbi2knhp65ho5n7vbsuthmd7gi 20 5 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 20 6 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 20 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 20 8 osmiophilic osmiophilic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 20 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 20 10 multivesicular multivesicular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 20 11 structures structure NNS work_zbi2knhp65ho5n7vbsuthmd7gi 20 12 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 20 13 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 20 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 20 15 treated treat VBN work_zbi2knhp65ho5n7vbsuthmd7gi 20 16 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 20 17 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 20 18 could could MD work_zbi2knhp65ho5n7vbsuthmd7gi 20 19 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 20 20 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 20 21 within within IN work_zbi2knhp65ho5n7vbsuthmd7gi 20 22 6 6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 20 23 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 20 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 20 25 reaching reach VBG work_zbi2knhp65ho5n7vbsuthmd7gi 20 26 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 20 27 plateau plateau NN work_zbi2knhp65ho5n7vbsuthmd7gi 20 28 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 20 29 18- 18- CD work_zbi2knhp65ho5n7vbsuthmd7gi 20 30 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 20 31 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 20 32 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 20 33 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 20 34 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 20 35 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 20 36 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 20 37 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 21 1 1D 1D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 21 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 21 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 22 1 Amodiaquine Amodiaquine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 22 2 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 22 3 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 22 4 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 22 5 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 22 6 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 22 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 22 8 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 22 9 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 22 10 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 22 11 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 22 12 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 22 13 Next next RB work_zbi2knhp65ho5n7vbsuthmd7gi 22 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 22 15 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 22 16 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 22 17 demonstrated demonstrate VBD work_zbi2knhp65ho5n7vbsuthmd7gi 22 18 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 22 19 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 22 20 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 22 21 accu- accu- NN work_zbi2knhp65ho5n7vbsuthmd7gi 22 22 mulation mulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 22 23 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 22 24 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 22 25 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 22 26 associated associate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 22 27 membrane membrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 22 28 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 22 29 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 22 30 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 22 31 LAMP1 LAMP1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 22 32 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 22 33 indicative indicative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 22 34 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 22 35 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 22 36 expansion expansion NN work_zbi2knhp65ho5n7vbsuthmd7gi 22 37 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 22 38 already already RB work_zbi2knhp65ho5n7vbsuthmd7gi 22 39 suggested suggest VBN work_zbi2knhp65ho5n7vbsuthmd7gi 22 40 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 22 41 TEM tem JJ work_zbi2knhp65ho5n7vbsuthmd7gi 22 42 visualization visualization NN work_zbi2knhp65ho5n7vbsuthmd7gi 22 43 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 22 44 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 22 45 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 23 1 2A).7,39 2a).7,39 LS work_zbi2knhp65ho5n7vbsuthmd7gi 23 2 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 23 3 parallel parallel JJ work_zbi2knhp65ho5n7vbsuthmd7gi 23 4 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 23 5 massive massive JJ work_zbi2knhp65ho5n7vbsuthmd7gi 23 6 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 23 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 23 8 LC3-II LC3-II NNP work_zbi2knhp65ho5n7vbsuthmd7gi 23 9 occurred occur VBD work_zbi2knhp65ho5n7vbsuthmd7gi 23 10 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 23 11 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 23 12 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 23 13 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 23 14 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 23 15 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 23 16 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 23 17 dose dose NN work_zbi2knhp65ho5n7vbsuthmd7gi 23 18 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 23 19 depen- depen- NN work_zbi2knhp65ho5n7vbsuthmd7gi 23 20 dent dent NN work_zbi2knhp65ho5n7vbsuthmd7gi 23 21 manner manner NN work_zbi2knhp65ho5n7vbsuthmd7gi 23 22 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 23 23 could could MD work_zbi2knhp65ho5n7vbsuthmd7gi 23 24 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 23 25 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 23 26 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 23 27 concentrations concentration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 23 28 as as RB work_zbi2knhp65ho5n7vbsuthmd7gi 23 29 low low JJ work_zbi2knhp65ho5n7vbsuthmd7gi 23 30 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 23 31 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 23 32 µM. µM. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 24 1 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 24 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 24 3 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 24 4 mammalian mammalian JJ work_zbi2knhp65ho5n7vbsuthmd7gi 24 5 homolog homolog NN work_zbi2knhp65ho5n7vbsuthmd7gi 24 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 24 7 yeast yeast NN work_zbi2knhp65ho5n7vbsuthmd7gi 24 8 Atg8 atg8 NN work_zbi2knhp65ho5n7vbsuthmd7gi 24 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 24 10 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 24 11 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 24 12 essential essential JJ work_zbi2knhp65ho5n7vbsuthmd7gi 24 13 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 24 14 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 24 15 autophagosome autophagosome JJ work_zbi2knhp65ho5n7vbsuthmd7gi 24 16 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 24 17 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 24 18 relocalizes relocalize VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 24 19 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 24 20 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 24 21 par- par- NN work_zbi2knhp65ho5n7vbsuthmd7gi 24 22 ticipates ticipate NNS work_zbi2knhp65ho5n7vbsuthmd7gi 24 23 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 24 24 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 24 25 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 24 26 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 24 27 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 24 28 autophagosomal autophagosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 24 29 membrane membrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 24 30 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 24 31 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 24 32 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 24 33 terminal terminal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 24 34 proteolytic proteolytic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 24 35 processing processing NN work_zbi2knhp65ho5n7vbsuthmd7gi 24 36 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 24 37 posttranslational posttranslational JJ work_zbi2knhp65ho5n7vbsuthmd7gi 24 38 phos- phos- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 24 39 pholipid pholipid JJ work_zbi2knhp65ho5n7vbsuthmd7gi 24 40 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 24 41 conjugation conjugation NN work_zbi2knhp65ho5n7vbsuthmd7gi 24 42 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 25 1 Therefore therefore RB work_zbi2knhp65ho5n7vbsuthmd7gi 25 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 25 3 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 25 4 relocalization relocalization NN work_zbi2knhp65ho5n7vbsuthmd7gi 25 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 25 6 LC3-I LC3-I NNP work_zbi2knhp65ho5n7vbsuthmd7gi 25 7 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 25 8 newly newly RB work_zbi2knhp65ho5n7vbsuthmd7gi 25 9 formed form VBN work_zbi2knhp65ho5n7vbsuthmd7gi 25 10 vesicles vesicle NNS work_zbi2knhp65ho5n7vbsuthmd7gi 25 11 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 25 12 more more RBR work_zbi2knhp65ho5n7vbsuthmd7gi 25 13 rapidly rapidly RB work_zbi2knhp65ho5n7vbsuthmd7gi 25 14 migrating migrate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 25 15 lipidated lipidate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 25 16 form form NN work_zbi2knhp65ho5n7vbsuthmd7gi 25 17 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 25 18 LC3-II LC3-II NNP work_zbi2knhp65ho5n7vbsuthmd7gi 25 19 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 25 20 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 25 21 detectable detectable JJ work_zbi2knhp65ho5n7vbsuthmd7gi 25 22 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 25 23 SDS SDS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 25 24 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 25 25 PAGE PAGE NNP work_zbi2knhp65ho5n7vbsuthmd7gi 25 26 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 25 27 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 25 28 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 26 1 2A).40 2a).40 CD work_zbi2knhp65ho5n7vbsuthmd7gi 26 2 Strikingly strikingly RB work_zbi2knhp65ho5n7vbsuthmd7gi 26 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 26 4 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 26 5 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 26 7 SQSTM1 SQSTM1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 8 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 26 9 p62 p62 NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 26 11 sequestosome sequestosome NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 12 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 26 13 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 26 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 26 15 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 26 16 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 26 17 cargo cargo NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 18 receptor receptor NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 19 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 26 20 substrate substrate VB work_zbi2knhp65ho5n7vbsuthmd7gi 26 21 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 26 22 undergoes undergo VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 26 23 depletion depletion NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 24 upon upon IN work_zbi2knhp65ho5n7vbsuthmd7gi 26 25 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 26 induction induction NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 27 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 26 28 occurred occur VBD work_zbi2knhp65ho5n7vbsuthmd7gi 26 29 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 26 30 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 26 31 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 32 level.7,41 level.7,41 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 33 - - : work_zbi2knhp65ho5n7vbsuthmd7gi 26 34 43 43 CD work_zbi2knhp65ho5n7vbsuthmd7gi 26 35 Similar similar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 26 36 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 37 occurred occur VBD work_zbi2knhp65ho5n7vbsuthmd7gi 26 38 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 26 39 SNCA SNCA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 40 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 26 41 α α NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 42 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 26 43 synuclein synuclein NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 44 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 26 45 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 26 46 another another DT work_zbi2knhp65ho5n7vbsuthmd7gi 26 47 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 26 48 substrate substrate NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 49 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 50 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 26 51 accumulates accumulate VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 26 52 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 26 53 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 26 54 consequence consequence NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 55 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 26 56 blocked block VBN work_zbi2knhp65ho5n7vbsuthmd7gi 26 57 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 26 58 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 26 59 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 26 60 flux.7,44,45 flux.7,44,45 NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 61 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 26 62 contrast contrast NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 63 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 26 64 BECN1 becn1 VB work_zbi2knhp65ho5n7vbsuthmd7gi 26 65 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 26 66 Beclin Beclin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 67 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 26 68 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 26 69 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 26 70 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 26 71 critical critical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 26 72 component component NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 73 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 26 74 © © NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 75 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 26 76 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 26 77 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 78 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 26 79 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 80 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 81 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 82 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 26 83 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 26 84 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 85 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 26 86 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 87 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 88 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 89 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 26 90 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 91 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 92 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 26 93 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 26 94 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 26 95 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 26 96 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 97 www.landesbioscience.com www.landesbioscience.com NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 98 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 99 2089 2089 CD work_zbi2knhp65ho5n7vbsuthmd7gi 26 100 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 26 101 class class NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 102 III iii CD work_zbi2knhp65ho5n7vbsuthmd7gi 26 103 PtdIns PtdIns NNP work_zbi2knhp65ho5n7vbsuthmd7gi 26 104 3-kinase 3-kinase CD work_zbi2knhp65ho5n7vbsuthmd7gi 26 105 complex complex NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 106 involved involve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 26 107 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 26 108 autophagosome autophagosome JJ work_zbi2knhp65ho5n7vbsuthmd7gi 26 109 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 110 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 26 111 remained remain VBD work_zbi2knhp65ho5n7vbsuthmd7gi 26 112 unchanged unchanged JJ work_zbi2knhp65ho5n7vbsuthmd7gi 26 113 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 26 114 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 26 115 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 116 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 26 117 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 26 118 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 27 1 2A 2A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 27 3 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 27 4 mRNA mRNA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 5 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 27 6 data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 27 7 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 27 8 shown show VBN work_zbi2knhp65ho5n7vbsuthmd7gi 27 9 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 27 10 levels.46 levels.46 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 11 Since since IN work_zbi2knhp65ho5n7vbsuthmd7gi 27 12 it -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 27 13 has have VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 27 14 been be VBN work_zbi2knhp65ho5n7vbsuthmd7gi 27 15 shown show VBN work_zbi2knhp65ho5n7vbsuthmd7gi 27 16 ear- ear- NNS work_zbi2knhp65ho5n7vbsuthmd7gi 27 17 lier li JJR work_zbi2knhp65ho5n7vbsuthmd7gi 27 18 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 27 19 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 27 20 aminophenol aminophenol NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 21 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 27 22 moiety moiety NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 23 contained contain VBN work_zbi2knhp65ho5n7vbsuthmd7gi 27 24 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 27 25 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 26 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 27 27 but but CC work_zbi2knhp65ho5n7vbsuthmd7gi 27 28 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 27 29 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 30 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 27 31 can can MD work_zbi2knhp65ho5n7vbsuthmd7gi 27 32 cause cause VB work_zbi2knhp65ho5n7vbsuthmd7gi 27 33 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 34 modification modification NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 35 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 27 36 haptenization haptenization NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 37 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 27 38 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 27 39 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 27 40 explored explore VBD work_zbi2knhp65ho5n7vbsuthmd7gi 27 41 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 27 42 possibility possibility NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 43 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 27 44 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 45 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 27 46 cause cause VB work_zbi2knhp65ho5n7vbsuthmd7gi 27 47 covalent covalent NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 48 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 49 adduction adduction NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 50 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 27 51 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 27 52 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 53 cells.47,48 cells.47,48 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 54 Using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 27 55 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 27 56 monoclonal monoclonal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 27 57 antibody antibody NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 58 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 27 59 6D10 6d10 NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 60 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 27 61 employed employ VBN work_zbi2knhp65ho5n7vbsuthmd7gi 27 62 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 27 63 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 27 64 immunodetection immunodetection NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 65 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 27 66 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 67 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 27 68 adducted adduct VBN work_zbi2knhp65ho5n7vbsuthmd7gi 27 69 plasma plasma NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 70 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 71 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 27 72 malaria malaria NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 73 patients patient NNS work_zbi2knhp65ho5n7vbsuthmd7gi 27 74 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 27 75 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 27 76 detected detect VBD work_zbi2knhp65ho5n7vbsuthmd7gi 27 77 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 27 78 accumula- accumula- NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 79 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 80 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 27 81 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 82 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 27 83 modified modify VBN work_zbi2knhp65ho5n7vbsuthmd7gi 27 84 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 27 85 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 27 86 35- 35- CD work_zbi2knhp65ho5n7vbsuthmd7gi 27 87 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 27 88 55-kDa 55-kda CD work_zbi2knhp65ho5n7vbsuthmd7gi 27 89 molecular molecular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 27 90 mass mass NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 91 range range NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 92 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 27 93 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 27 94 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 95 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 27 96 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 27 97 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 27 98 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 99 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 27 100 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 27 101 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 27 102 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 27 103 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 27 104 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 105 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 27 106 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 27 107 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 28 1 2A 2a LS work_zbi2knhp65ho5n7vbsuthmd7gi 28 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 28 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 29 1 However however RB work_zbi2knhp65ho5n7vbsuthmd7gi 29 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 29 3 identity identity NN work_zbi2knhp65ho5n7vbsuthmd7gi 29 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 29 5 adducted adducted JJ work_zbi2knhp65ho5n7vbsuthmd7gi 29 6 target target NN work_zbi2knhp65ho5n7vbsuthmd7gi 29 7 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 29 8 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 29 9 causative causative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 29 10 involvement involvement NN work_zbi2knhp65ho5n7vbsuthmd7gi 29 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 29 12 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 29 13 adduction adduction NN work_zbi2knhp65ho5n7vbsuthmd7gi 29 14 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 29 15 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 29 16 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 29 17 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 29 18 autophagic- autophagic- NN work_zbi2knhp65ho5n7vbsuthmd7gi 29 19 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 29 20 impairment impairment NN work_zbi2knhp65ho5n7vbsuthmd7gi 29 21 remain remain VBP work_zbi2knhp65ho5n7vbsuthmd7gi 29 22 undefined undefined JJ work_zbi2knhp65ho5n7vbsuthmd7gi 29 23 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 29 24 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 29 25 point point NN work_zbi2knhp65ho5n7vbsuthmd7gi 29 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 30 1 Consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 30 2 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 30 3 TEM tem NN work_zbi2knhp65ho5n7vbsuthmd7gi 30 4 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 30 5 visualization visualization NN work_zbi2knhp65ho5n7vbsuthmd7gi 30 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 30 7 osmiophilic osmiophilic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 30 8 vesicles vesicle NNS work_zbi2knhp65ho5n7vbsuthmd7gi 30 9 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 30 10 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 30 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 31 1 1C 1C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 31 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 31 3 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 31 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 31 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 31 6 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 31 7 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 31 8 displayed display VBD work_zbi2knhp65ho5n7vbsuthmd7gi 31 9 increased increase VBN work_zbi2knhp65ho5n7vbsuthmd7gi 31 10 lipofuscin lipofuscin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 31 11 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 31 12 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 31 13 evidenced evidence VBN work_zbi2knhp65ho5n7vbsuthmd7gi 31 14 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 31 15 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 31 16 cytometric cytometric JJ work_zbi2knhp65ho5n7vbsuthmd7gi 31 17 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 31 18 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 31 19 autofluorescent autofluorescent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 31 20 intracellular intracellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 31 21 material material NN work_zbi2knhp65ho5n7vbsuthmd7gi 31 22 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 31 23 formed form VBN work_zbi2knhp65ho5n7vbsuthmd7gi 31 24 upon upon IN work_zbi2knhp65ho5n7vbsuthmd7gi 31 25 pro- pro- NN work_zbi2knhp65ho5n7vbsuthmd7gi 31 26 longed long VBN work_zbi2knhp65ho5n7vbsuthmd7gi 31 27 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 31 28 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 31 29 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 31 30 24–48 24–48 NN work_zbi2knhp65ho5n7vbsuthmd7gi 31 31 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 31 32 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 31 33 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 31 34 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 32 1 2B 2B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 32 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 32 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 32 4 changes change VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 32 5 indicative indicative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 32 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 32 7 impaired impaired JJ work_zbi2knhp65ho5n7vbsuthmd7gi 32 8 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 32 9 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 32 10 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 32 11 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 32 12 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 32 13 described describe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 32 14 before.7,37,38 before.7,37,38 . work_zbi2knhp65ho5n7vbsuthmd7gi 32 15 Importantly importantly RB work_zbi2knhp65ho5n7vbsuthmd7gi 32 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 32 17 similar similar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 32 18 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 32 19 affecting affect VBG work_zbi2knhp65ho5n7vbsuthmd7gi 32 20 LAMP1 LAMP1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 32 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 32 22 LC3-II LC3-II NNP work_zbi2knhp65ho5n7vbsuthmd7gi 32 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 32 24 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 32 25 SQSTM1 SQSTM1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 32 26 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 32 27 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 32 28 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 32 29 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 32 30 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 32 31 metastatic metastatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 32 32 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 32 33 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 32 34 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 32 35 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 32 36 low low JJ work_zbi2knhp65ho5n7vbsuthmd7gi 32 37 micromolar micromolar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 32 38 concentrations concentration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 32 39 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 32 40 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 32 41 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 32 42 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 32 43 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 33 1 2C 2C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 33 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 33 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 34 1 After after IN work_zbi2knhp65ho5n7vbsuthmd7gi 34 2 demonstrating demonstrate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 34 3 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 34 5 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 6 substrates substrate NNS work_zbi2knhp65ho5n7vbsuthmd7gi 34 7 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 34 8 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 34 9 marker marker NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 10 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 34 11 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 34 12 LC3-II LC3-II NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 34 14 SQSTM1 SQSTM1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 34 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 34 16 SNCA SNCA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 34 18 LAMP1 lamp1 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 34 19 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 34 20 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 34 21 gathered gather VBD work_zbi2knhp65ho5n7vbsuthmd7gi 34 22 further further JJ work_zbi2knhp65ho5n7vbsuthmd7gi 34 23 mechanistic mechanistic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 34 24 evidence evidence NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 25 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 34 26 support support NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 27 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 34 28 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 29 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 34 30 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 34 31 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 34 32 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 34 33 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 34 34 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 35 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 34 36 monitoring monitor VBG work_zbi2knhp65ho5n7vbsuthmd7gi 34 37 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 38 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 39 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 40 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 34 41 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 42 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 43 cells.49 cells.49 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 44 To to IN work_zbi2knhp65ho5n7vbsuthmd7gi 34 45 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 34 46 end end NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 47 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 34 48 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 34 49 transfected transfecte VBN work_zbi2knhp65ho5n7vbsuthmd7gi 34 50 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 34 51 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 34 52 tandem tandem NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 53 reporter reporter NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 54 construct construct NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 55 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 34 56 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 57 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 34 58 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 59 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 34 60 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 61 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 34 62 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 34 63 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 34 64 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 34 65 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 66 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 34 67 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 34 68 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 69 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 34 70 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 34 71 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 72 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 34 73 followed follow VBN work_zbi2knhp65ho5n7vbsuthmd7gi 34 74 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 34 75 assessment assessment NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 76 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 34 77 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 78 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 34 79 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 80 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 34 81 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 82 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 34 83 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 34 84 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 85 colocalization colocalization NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 86 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 34 87 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 34 88 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 35 1 2D).6,49 2d).6,49 CD work_zbi2knhp65ho5n7vbsuthmd7gi 35 2 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 35 3 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 35 4 fluorescence fluorescence NNP work_zbi2knhp65ho5n7vbsuthmd7gi 35 5 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 35 6 quenched quench VBN work_zbi2knhp65ho5n7vbsuthmd7gi 35 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 35 8 acidic acidic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 35 9 environments environment NNS work_zbi2knhp65ho5n7vbsuthmd7gi 35 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 35 11 such such JJ work_zbi2knhp65ho5n7vbsuthmd7gi 35 12 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 35 13 that that DT work_zbi2knhp65ho5n7vbsuthmd7gi 35 14 encountered encounter VBN work_zbi2knhp65ho5n7vbsuthmd7gi 35 15 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 35 16 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 35 17 autolysosome autolysosome NN work_zbi2knhp65ho5n7vbsuthmd7gi 35 18 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 35 19 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 35 20 whereas whereas IN work_zbi2knhp65ho5n7vbsuthmd7gi 35 21 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 35 22 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 35 23 more more RBR work_zbi2knhp65ho5n7vbsuthmd7gi 35 24 stable stable JJ work_zbi2knhp65ho5n7vbsuthmd7gi 35 25 under under IN work_zbi2knhp65ho5n7vbsuthmd7gi 35 26 acidic acidic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 35 27 conditions condition NNS work_zbi2knhp65ho5n7vbsuthmd7gi 35 28 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 36 1 Therefore therefore RB work_zbi2knhp65ho5n7vbsuthmd7gi 36 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 36 3 colocalization colocalization NN work_zbi2knhp65ho5n7vbsuthmd7gi 36 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 36 5 both both CC work_zbi2knhp65ho5n7vbsuthmd7gi 36 6 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 36 7 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 36 8 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 36 9 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 36 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 36 11 yellow yellow NNP work_zbi2knhp65ho5n7vbsuthmd7gi 36 12 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 36 13 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 36 14 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 36 15 merged merged JJ work_zbi2knhp65ho5n7vbsuthmd7gi 36 16 image image NN work_zbi2knhp65ho5n7vbsuthmd7gi 36 17 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 36 18 indicates indicate VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 36 19 either either CC work_zbi2knhp65ho5n7vbsuthmd7gi 36 20 autophagosomal autophagosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 36 21 localization localization NN work_zbi2knhp65ho5n7vbsuthmd7gi 36 22 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 36 23 upstream upstream NN work_zbi2knhp65ho5n7vbsuthmd7gi 36 24 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 36 25 fusion fusion NN work_zbi2knhp65ho5n7vbsuthmd7gi 36 26 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 36 27 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 36 28 acidic acidic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 36 29 lysosome lysosome NN work_zbi2knhp65ho5n7vbsuthmd7gi 36 30 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 36 31 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 36 32 autolysosomal autolysosomal VB work_zbi2knhp65ho5n7vbsuthmd7gi 36 33 localization localization NN work_zbi2knhp65ho5n7vbsuthmd7gi 36 34 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 36 35 i.e. i.e. FW work_zbi2knhp65ho5n7vbsuthmd7gi 36 36 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 36 37 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 36 38 autolysosomes autolysosome NNS work_zbi2knhp65ho5n7vbsuthmd7gi 36 39 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 36 40 disrupted disrupt VBN work_zbi2knhp65ho5n7vbsuthmd7gi 36 41 acidification acidification NN work_zbi2knhp65ho5n7vbsuthmd7gi 36 42 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 36 43 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 37 1 Indeed indeed RB work_zbi2knhp65ho5n7vbsuthmd7gi 37 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 37 3 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 37 4 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 37 5 Figure figure NN work_zbi2knhp65ho5n7vbsuthmd7gi 37 6   _SP work_zbi2knhp65ho5n7vbsuthmd7gi 37 7 1 1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 37 8 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 37 9 amodiaquine amodiaquine RB work_zbi2knhp65ho5n7vbsuthmd7gi 37 10 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 37 11 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 37 12 morphological morphological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 37 13 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 37 14 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 37 15 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 37 16 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 37 17 a375 a375 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 37 18 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 37 19 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 37 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 38 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 38 2 A a DT work_zbi2knhp65ho5n7vbsuthmd7gi 38 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 38 4 chemical chemical NN work_zbi2knhp65ho5n7vbsuthmd7gi 38 5 structure structure NN work_zbi2knhp65ho5n7vbsuthmd7gi 38 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 38 7 aQ. aq. NN work_zbi2knhp65ho5n7vbsuthmd7gi 39 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 39 2 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 39 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 39 4 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 39 5 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 39 6 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 39 7 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 39 8 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 39 9 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 39 10 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 39 11 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 39 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 39 13 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 39 14 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 39 15 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 39 16 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 39 17 remained remain VBD work_zbi2knhp65ho5n7vbsuthmd7gi 39 18 untreated untreated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 39 19 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 39 20 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 39 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 39 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 40 1 Visualization visualization NN work_zbi2knhp65ho5n7vbsuthmd7gi 40 2 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 40 3 light light NN work_zbi2knhp65ho5n7vbsuthmd7gi 40 4 microscopy microscopy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 40 5 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 40 6 upper upper JJ work_zbi2knhp65ho5n7vbsuthmd7gi 40 7 panel panel NN work_zbi2knhp65ho5n7vbsuthmd7gi 40 8 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 40 9 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 40 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 40 11 bottom bottom JJ work_zbi2knhp65ho5n7vbsuthmd7gi 40 12 panel panel NN work_zbi2knhp65ho5n7vbsuthmd7gi 40 13 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 40 14 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 40 15 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 40 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 41 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 41 2 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 41 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 41 4 Transmission Transmission NNP work_zbi2knhp65ho5n7vbsuthmd7gi 41 5 elec- elec- FW work_zbi2knhp65ho5n7vbsuthmd7gi 41 6 tron tron NNP work_zbi2knhp65ho5n7vbsuthmd7gi 41 7 microscopy microscopy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 41 8 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 42 1 left left JJ work_zbi2knhp65ho5n7vbsuthmd7gi 42 2 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 42 3 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 42 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 42 5 middle middle JJ work_zbi2knhp65ho5n7vbsuthmd7gi 42 6 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 42 7 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 42 8 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 42 9 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 42 10 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 42 11 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 42 12 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 42 13 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 42 14 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 42 15 2,650-fold 2,650-fold CD work_zbi2knhp65ho5n7vbsuthmd7gi 42 16 direct direct JJ work_zbi2knhp65ho5n7vbsuthmd7gi 42 17 magnification magnification NN work_zbi2knhp65ho5n7vbsuthmd7gi 42 18 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 42 19 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 42 20 right right JJ work_zbi2knhp65ho5n7vbsuthmd7gi 42 21 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 42 22 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 42 23 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 42 24 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 42 25 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 42 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 42 27 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 42 28 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 42 29 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 42 30 25,000-fold 25,000-fold CD work_zbi2knhp65ho5n7vbsuthmd7gi 42 31 direct direct JJ work_zbi2knhp65ho5n7vbsuthmd7gi 42 32 magnification magnification NN work_zbi2knhp65ho5n7vbsuthmd7gi 42 33 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 42 34 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 43 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 43 2 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 43 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 43 4 Transmission transmission NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 5 electron electron NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 6 microscopy microscopy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 43 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 43 8 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 9 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 43 10 course course NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 11 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 43 13 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 43 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 43 15 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 43 16 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 43 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 43 18 6–18 6–18 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 43 19 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 20 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 43 21 2,650-fold 2,650-fold CD work_zbi2knhp65ho5n7vbsuthmd7gi 43 22 direct direct JJ work_zbi2knhp65ho5n7vbsuthmd7gi 43 23 magnification magnification NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 24 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 43 25 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 43 26 right right JJ work_zbi2knhp65ho5n7vbsuthmd7gi 43 27 panel panel NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 28 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 43 29 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 43 30 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 43 31 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 43 32 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 43 33 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 43 34 18 18 CD work_zbi2knhp65ho5n7vbsuthmd7gi 43 35 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 36 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 43 37 25,000-fold 25,000-fold CD work_zbi2knhp65ho5n7vbsuthmd7gi 43 38 direct direct JJ work_zbi2knhp65ho5n7vbsuthmd7gi 43 39 magnification magnification NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 40 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 43 41 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 43 42 M m NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 43 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 43 44 mitochondrion mitochondrion NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 45 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 43 46 N n NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 47 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 43 48 nucleus nucleus NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 49 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 43 50 V v NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 51 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 43 52 single single JJ work_zbi2knhp65ho5n7vbsuthmd7gi 43 53 membrane membrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 43 54 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 43 55 enclosed enclose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 43 56 osmiophilic osmiophilic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 43 57 multivesicles multivesicle NNS work_zbi2knhp65ho5n7vbsuthmd7gi 43 58 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 44 1 © © LS work_zbi2knhp65ho5n7vbsuthmd7gi 44 2 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 44 3 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 44 4 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 5 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 44 6 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 7 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 44 8 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 9 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 44 10 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 44 11 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 44 12 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 44 13 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 44 14 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 44 15 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 16 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 44 17 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 18 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 19 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 44 20 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 44 21 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 44 22 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 44 23 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 44 24 2090 2090 CD work_zbi2knhp65ho5n7vbsuthmd7gi 44 25 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 44 26 Volume Volume NNP work_zbi2knhp65ho5n7vbsuthmd7gi 44 27 9 9 CD work_zbi2knhp65ho5n7vbsuthmd7gi 44 28 issue issue NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 29 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 44 30 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 44 31 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 44 32 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 44 33 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 34 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 44 35 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 44 36 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 37 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 44 38 displayed display VBD work_zbi2knhp65ho5n7vbsuthmd7gi 44 39 both both DT work_zbi2knhp65ho5n7vbsuthmd7gi 44 40 green green JJ work_zbi2knhp65ho5n7vbsuthmd7gi 44 41 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 44 42 red red JJ work_zbi2knhp65ho5n7vbsuthmd7gi 44 43 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 44 intensity intensity NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 45 producing produce VBG work_zbi2knhp65ho5n7vbsuthmd7gi 44 46 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 44 47 yellow yellow JJ work_zbi2knhp65ho5n7vbsuthmd7gi 44 48 overlay overlay NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 49 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 44 50 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 44 51 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 44 52 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 53 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 44 54 autolysosomes autolysosome NNS work_zbi2knhp65ho5n7vbsuthmd7gi 44 55 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 44 56 dis- dis- IN work_zbi2knhp65ho5n7vbsuthmd7gi 44 57 play play VB work_zbi2knhp65ho5n7vbsuthmd7gi 44 58 impaired impaired JJ work_zbi2knhp65ho5n7vbsuthmd7gi 44 59 acidification acidification NN work_zbi2knhp65ho5n7vbsuthmd7gi 44 60 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 45 1 Furthermore furthermore RB work_zbi2knhp65ho5n7vbsuthmd7gi 45 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 45 3 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 45 4 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 45 5 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 45 6 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 45 7 bafilomycin bafilomycin VBN work_zbi2knhp65ho5n7vbsuthmd7gi 45 8 A a DT work_zbi2knhp65ho5n7vbsuthmd7gi 45 9 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 45 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 45 11 BafA BafA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 45 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 45 13 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 45 14 standard standard JJ work_zbi2knhp65ho5n7vbsuthmd7gi 45 15 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 45 16 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 45 17 lysosomal lysosomal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 45 18 acidi- acidi- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 45 19 fication fication NNP work_zbi2knhp65ho5n7vbsuthmd7gi 45 20 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 45 21 substrate substrate VB work_zbi2knhp65ho5n7vbsuthmd7gi 45 22 degradation degradation NN work_zbi2knhp65ho5n7vbsuthmd7gi 45 23 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 45 24 impairs impair VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 45 25 autophagosome- autophagosome- XX work_zbi2knhp65ho5n7vbsuthmd7gi 45 26 lysosome lysosome NNP work_zbi2knhp65ho5n7vbsuthmd7gi 45 27 fusion50 fusion50 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 45 28 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 45 29 displayed display VBD work_zbi2knhp65ho5n7vbsuthmd7gi 45 30 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 45 31 LC3-fluorescence lc3-fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 45 32 pattern pattern NN work_zbi2knhp65ho5n7vbsuthmd7gi 45 33 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 45 34 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 45 35 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 45 36 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 45 37 yellow yellow JJ work_zbi2knhp65ho5n7vbsuthmd7gi 45 38 overlay overlay NN work_zbi2knhp65ho5n7vbsuthmd7gi 45 39 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 45 40 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 45 41 mimicked mimic VBD work_zbi2knhp65ho5n7vbsuthmd7gi 45 42 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 45 43 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 45 44 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 45 45 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 45 46 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 45 47 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 46 1 Moreover moreover RB work_zbi2knhp65ho5n7vbsuthmd7gi 46 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 46 3 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 4 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 46 5 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 46 6 published publish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 46 7 litera- litera- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 8 ture ture NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 9 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 46 10 lysosomotropic lysosomotropic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 11 agents agent NNS work_zbi2knhp65ho5n7vbsuthmd7gi 46 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 46 13 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 14 imaging imaging NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 15 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 46 16 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 46 17 pH pH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 46 18 sensitive sensitive JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 19 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 20 probe probe NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 21 LysoSensor LysoSensor NNP work_zbi2knhp65ho5n7vbsuthmd7gi 46 22 ™ ™ CD work_zbi2knhp65ho5n7vbsuthmd7gi 46 23 Green Green NNP work_zbi2knhp65ho5n7vbsuthmd7gi 46 24 DND-189 dnd-189 RB work_zbi2knhp65ho5n7vbsuthmd7gi 46 25 revealed reveal VBD work_zbi2knhp65ho5n7vbsuthmd7gi 46 26 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 46 27 similar similar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 28 pattern pattern NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 29 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 46 30 impaired impaired JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 31 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 32 acidification acidification NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 33 resulting result VBG work_zbi2knhp65ho5n7vbsuthmd7gi 46 34 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 46 35 rapid rapid JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 36 loss loss NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 37 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 46 38 pH pH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 46 39 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 40 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 46 41 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 42 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 46 43 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 44 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 46 45 either either CC work_zbi2knhp65ho5n7vbsuthmd7gi 46 46 BafA BafA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 46 47 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 46 48 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 46 49 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 46 50 data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 46 51 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 46 52 shown).51 shown).51 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 53 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 46 54 order order NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 55 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 46 56 gain gain VB work_zbi2knhp65ho5n7vbsuthmd7gi 46 57 further further JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 58 insight insight NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 59 into into IN work_zbi2knhp65ho5n7vbsuthmd7gi 46 60 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 46 61 mecha- mecha- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 62 nism nism NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 63 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 46 64 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 46 65 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 46 66 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 46 67 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 68 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 46 69 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 70 alterations alteration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 46 71 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 46 72 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 46 73 LC3 lc3 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 46 74 turnover turnover NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 75 assay assay NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 76 employing employ VBG work_zbi2knhp65ho5n7vbsuthmd7gi 46 77 BafA BafA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 46 78 cotreatment cotreatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 79 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 46 80 performed perform VBN work_zbi2knhp65ho5n7vbsuthmd7gi 46 81 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 46 82 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 46 83 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 47 1 3A).49 3a).49 CD work_zbi2knhp65ho5n7vbsuthmd7gi 47 2 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 47 3 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 47 4 assay assay NN work_zbi2knhp65ho5n7vbsuthmd7gi 47 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 47 6 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 47 7 assessed assess VBD work_zbi2knhp65ho5n7vbsuthmd7gi 47 8 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 47 9 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 47 10 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 47 11 LC3-II lc3-ii JJ work_zbi2knhp65ho5n7vbsuthmd7gi 47 12 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 47 13 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 47 14 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 47 15 pres- pres- NN work_zbi2knhp65ho5n7vbsuthmd7gi 47 16 ence ence NN work_zbi2knhp65ho5n7vbsuthmd7gi 47 17 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 47 18 absence absence NN work_zbi2knhp65ho5n7vbsuthmd7gi 47 19 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 47 20 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 47 21 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 47 22 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 47 23 BafA. BafA. . work_zbi2knhp65ho5n7vbsuthmd7gi 48 1 As as IN work_zbi2knhp65ho5n7vbsuthmd7gi 48 2 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 48 3 above above IN work_zbi2knhp65ho5n7vbsuthmd7gi 48 4 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 48 5 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 48 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 49 1 2A 2a LS work_zbi2knhp65ho5n7vbsuthmd7gi 49 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 49 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 49 4 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 49 5 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 49 6 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 49 7 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 49 8 increase increase NN work_zbi2knhp65ho5n7vbsuthmd7gi 49 9 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 49 10 LC3-II lc3-ii JJ work_zbi2knhp65ho5n7vbsuthmd7gi 49 11 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 49 12 within within IN work_zbi2knhp65ho5n7vbsuthmd7gi 49 13 4–8 4–8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 49 14 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 49 15 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 49 16 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 49 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 50 1 Importantly importantly RB work_zbi2knhp65ho5n7vbsuthmd7gi 50 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 50 3 if if IN work_zbi2knhp65ho5n7vbsuthmd7gi 50 4 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 50 5 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 50 6 occurred occur VBD work_zbi2knhp65ho5n7vbsuthmd7gi 50 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 50 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 50 9 presence presence NN work_zbi2knhp65ho5n7vbsuthmd7gi 50 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 50 11 BafA BafA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 50 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 50 13 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 50 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 50 15 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 50 16 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 50 17 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 50 18 LC3-II lc3-ii JJ work_zbi2knhp65ho5n7vbsuthmd7gi 50 19 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 50 20 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 50 21 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 50 22 potentiated potentiate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 50 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 50 24 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 50 25 observation observation NN work_zbi2knhp65ho5n7vbsuthmd7gi 50 26 most most RBS work_zbi2knhp65ho5n7vbsuthmd7gi 50 27 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 50 28 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 50 29 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 50 30 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 50 31 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 50 32 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 50 33 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 50 34 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 50 35 LC3-II lc3-ii JJ work_zbi2knhp65ho5n7vbsuthmd7gi 50 36 deg- deg- NN work_zbi2knhp65ho5n7vbsuthmd7gi 50 37 radation radation NN work_zbi2knhp65ho5n7vbsuthmd7gi 50 38 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 50 39 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 50 40 autolysosomal autolysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 50 41 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 50 42 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 51 1 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 51 2 support support NN work_zbi2knhp65ho5n7vbsuthmd7gi 51 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 51 4 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 51 5 direct direct JJ work_zbi2knhp65ho5n7vbsuthmd7gi 51 6 impairment impairment NN work_zbi2knhp65ho5n7vbsuthmd7gi 51 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 51 8 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 51 9 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 51 10 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 51 11 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 51 12 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 51 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 51 14 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 51 15 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 51 16 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 51 17 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 51 18 enzymatic enzymatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 51 19 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 51 20 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 51 21 detected detect VBN work_zbi2knhp65ho5n7vbsuthmd7gi 51 22 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 51 23 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 51 24 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 51 25 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 51 26 occurred occur VBD work_zbi2knhp65ho5n7vbsuthmd7gi 51 27 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 51 28 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 51 29 dose- dose- NN work_zbi2knhp65ho5n7vbsuthmd7gi 51 30 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 51 31 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 51 32 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 51 33 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 51 34 manner manner NN work_zbi2knhp65ho5n7vbsuthmd7gi 51 35 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 51 36 1–20 1–20 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 51 37 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 51 38 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 51 39 1–24 1–24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 51 40 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 51 41 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 51 42 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 51 43 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 52 1 3B 3B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 52 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 52 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 53 1 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 53 2 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 53 3 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 53 4 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 53 5 enzyme enzyme NNS work_zbi2knhp65ho5n7vbsuthmd7gi 53 6 inactivation inactivation NN work_zbi2knhp65ho5n7vbsuthmd7gi 53 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 53 8 both both DT work_zbi2knhp65ho5n7vbsuthmd7gi 53 9 cys- cys- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 53 10 teine- teine- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 53 11 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 53 12 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 53 13 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 53 14 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 53 15 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 53 16 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 53 17 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 53 18 CTSL CTSL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 53 19 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 53 20 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 53 21 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 53 22 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 53 23 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 53 24 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 53 25 aspartate aspartate NN work_zbi2knhp65ho5n7vbsuthmd7gi 53 26 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 53 27 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 53 28 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 53 29 CTSD CTSD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 53 30 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 53 31 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 53 32 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 53 33 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 53 34 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 53 35 cathepsins cathepsin NNS work_zbi2knhp65ho5n7vbsuthmd7gi 53 36 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 53 37 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 53 38 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 53 39 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 53 40 global global JJ work_zbi2knhp65ho5n7vbsuthmd7gi 53 41 impairment impairment NN work_zbi2knhp65ho5n7vbsuthmd7gi 53 42 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 53 43 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 53 44 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 53 45 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 53 46 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 53 47 lysosomotropic lysosomotropic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 53 48 4-ami- 4-ami- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 53 49 noquinoline noquinoline NN work_zbi2knhp65ho5n7vbsuthmd7gi 53 50 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 53 51 derivative derivative NN work_zbi2knhp65ho5n7vbsuthmd7gi 53 52 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 54 1 Remarkably remarkably RB work_zbi2knhp65ho5n7vbsuthmd7gi 54 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 54 3 within within IN work_zbi2knhp65ho5n7vbsuthmd7gi 54 4 only only RB work_zbi2knhp65ho5n7vbsuthmd7gi 54 5 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 54 6 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 54 7 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 54 8 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 54 9 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 54 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 54 11 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 54 12 enzymatic enzymatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 54 13 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 54 14 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 54 15 already already RB work_zbi2knhp65ho5n7vbsuthmd7gi 54 16 reduced reduce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 54 17 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 54 18 almost almost RB work_zbi2knhp65ho5n7vbsuthmd7gi 54 19 25 25 CD work_zbi2knhp65ho5n7vbsuthmd7gi 54 20 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 54 21 diminishing diminish VBG work_zbi2knhp65ho5n7vbsuthmd7gi 54 22 further further RB work_zbi2knhp65ho5n7vbsuthmd7gi 54 23 over over IN work_zbi2knhp65ho5n7vbsuthmd7gi 54 24 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 54 25 next next JJ work_zbi2knhp65ho5n7vbsuthmd7gi 54 26 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 54 27 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 54 28 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 54 29 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 54 30 only only RB work_zbi2knhp65ho5n7vbsuthmd7gi 54 31 approximately approximately RB work_zbi2knhp65ho5n7vbsuthmd7gi 54 32 30 30 CD work_zbi2knhp65ho5n7vbsuthmd7gi 54 33 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 54 34 residual residual JJ work_zbi2knhp65ho5n7vbsuthmd7gi 54 35 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 54 36 detectable detectable NN work_zbi2knhp65ho5n7vbsuthmd7gi 54 37 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 55 1 This this DT work_zbi2knhp65ho5n7vbsuthmd7gi 55 2 inhibitory inhibitory JJ work_zbi2knhp65ho5n7vbsuthmd7gi 55 3 effect effect NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 4 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 55 5 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 6 accordance accordance NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 7 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 55 9 documented document VBN work_zbi2knhp65ho5n7vbsuthmd7gi 55 10 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 12 lyso- lyso- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 55 13 somotropic somotropic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 55 14 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 55 15 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 55 16 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 55 17 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 18 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 55 19 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 20 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 55 21 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 55 22 disrupt disrupt VBP work_zbi2knhp65ho5n7vbsuthmd7gi 55 23 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 55 24 acidic acidic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 55 25 food food NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 26 vacuole vacuole NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 27 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 28 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 55 29 plasmo- plasmo- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 30 dium dium NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 31 parasite parasite NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 32 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 55 33 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 55 34 compromise compromise VB work_zbi2knhp65ho5n7vbsuthmd7gi 55 35 mammalian mammalian JJ work_zbi2knhp65ho5n7vbsuthmd7gi 55 36 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 37 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 38 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 39 through through IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 40 alkalinization alkalinization NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 41 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 55 42 membrane membrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 43 destabilization.52,53 destabilization.52,53 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 44 Interestingly interestingly RB work_zbi2knhp65ho5n7vbsuthmd7gi 55 45 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 55 46 recent recent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 55 47 evidence evidence NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 48 indicates indicate VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 55 49 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 50 lysosomal lysosomal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 51 cathepsins cathepsin VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 55 52 includ- includ- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 53 ing ing NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 54 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 55 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 55 56 CTSD CTSD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 57 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 55 58 involved involve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 55 59 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 60 LC3-II lc3-ii JJ work_zbi2knhp65ho5n7vbsuthmd7gi 55 61 proteo- proteo- NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 62 lytic lytic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 55 63 turnover turnover NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 64 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 55 65 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 66 pharmacological pharmacological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 55 67 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 68 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 69 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 70 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 55 71 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 72 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 73 LC3-II LC3-II NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 74 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 55 75 support- support- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 76 ing e VBG work_zbi2knhp65ho5n7vbsuthmd7gi 55 77 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 55 78 hypothesis hypothesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 79 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 80 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 81 inactivation inactivation NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 82 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 55 83 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 55 84 causative causative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 55 85 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 86 underlying underlie VBG work_zbi2knhp65ho5n7vbsuthmd7gi 55 87 massive massive JJ work_zbi2knhp65ho5n7vbsuthmd7gi 55 88 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 89 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 90 LC3-II LC3-II NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 91 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 92 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 55 93 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 55 94 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 95 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 55 96 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 55 97 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 55 98 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 99 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 55 100 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 55 101 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 55 102 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 56 1 2A).54,55 2a).54,55 CD work_zbi2knhp65ho5n7vbsuthmd7gi 56 2 Importantly importantly RB work_zbi2knhp65ho5n7vbsuthmd7gi 56 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 56 4 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 56 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 56 6 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 56 7 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 56 8 CTSL CTSL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 56 9 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 56 10 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 56 11 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 56 12 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 56 13 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 56 14 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 56 15 observable observable JJ work_zbi2knhp65ho5n7vbsuthmd7gi 56 16 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 56 17 other other JJ work_zbi2knhp65ho5n7vbsuthmd7gi 56 18 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 56 19 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 56 20 lines line NNS work_zbi2knhp65ho5n7vbsuthmd7gi 56 21 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 56 22 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 56 23 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 56 24 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 56 25 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 57 1 3C 3c NN work_zbi2knhp65ho5n7vbsuthmd7gi 57 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 57 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 58 1 However however RB work_zbi2knhp65ho5n7vbsuthmd7gi 58 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 58 3 CTSD ctsd JJ work_zbi2knhp65ho5n7vbsuthmd7gi 58 4 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 58 5 remained remain VBD work_zbi2knhp65ho5n7vbsuthmd7gi 58 6 undiminished undiminished JJ work_zbi2knhp65ho5n7vbsuthmd7gi 58 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 58 8 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 58 9 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 58 10 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 58 11 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 58 12 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 58 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 58 14 indicating indicate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 58 15 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 58 16 differ- differ- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 58 17 ential ential JJ work_zbi2knhp65ho5n7vbsuthmd7gi 58 18 sensitivity sensitivity NN work_zbi2knhp65ho5n7vbsuthmd7gi 58 19 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 58 20 cysteine cysteine NN work_zbi2knhp65ho5n7vbsuthmd7gi 58 21 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 58 22 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 58 23 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 58 24 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 58 25 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 58 26 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 58 27 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 58 28 vs. vs. FW work_zbi2knhp65ho5n7vbsuthmd7gi 58 29 aspartate- aspartate- FW work_zbi2knhp65ho5n7vbsuthmd7gi 58 30 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 58 31 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 58 32 CTSD CTSD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 58 33 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 58 34 cathepsins cathepsin VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 58 35 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 58 36 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 58 37 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 58 38 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 58 39 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 58 40 phenomenon phenomenon NN work_zbi2knhp65ho5n7vbsuthmd7gi 58 41 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 58 42 remains remain VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 58 43 poorly poorly RB work_zbi2knhp65ho5n7vbsuthmd7gi 58 44 understood understand VBN work_zbi2knhp65ho5n7vbsuthmd7gi 58 45 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 58 46 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 58 47 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 58 48 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 59 1 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 59 2 induces induce VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 59 3 energy energy NN work_zbi2knhp65ho5n7vbsuthmd7gi 59 4 crisis crisis NN work_zbi2knhp65ho5n7vbsuthmd7gi 59 5 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 59 6 sensitizes sensitize VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 59 7 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 59 8 mela- mela- NN work_zbi2knhp65ho5n7vbsuthmd7gi 59 9 noma noma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 59 10 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 59 11 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 59 12 starvation- starvation- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 59 13 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 59 14 chemotherapeutic chemotherapeutic RB work_zbi2knhp65ho5n7vbsuthmd7gi 59 15 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 59 16 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 59 17 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 59 18 Next next RB work_zbi2knhp65ho5n7vbsuthmd7gi 59 19 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 59 20 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 59 21 examined examine VBD work_zbi2knhp65ho5n7vbsuthmd7gi 59 22 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 59 23 modulation modulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 59 24 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 59 25 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 59 26 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 59 27 vul- vul- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 59 28 nerability nerability NN work_zbi2knhp65ho5n7vbsuthmd7gi 59 29 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 59 30 starvation starvation NN work_zbi2knhp65ho5n7vbsuthmd7gi 59 31 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 59 32 chemotherapeutic chemotherapeutic NN work_zbi2knhp65ho5n7vbsuthmd7gi 59 33 intervention intervention NN work_zbi2knhp65ho5n7vbsuthmd7gi 59 34 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 59 35 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 59 36 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 60 1 4 4 LS work_zbi2knhp65ho5n7vbsuthmd7gi 60 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 60 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 61 1 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 61 2 untreated untreated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 61 3 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 61 4 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 61 5 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 61 6 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 61 7 Hank Hank NNP work_zbi2knhp65ho5n7vbsuthmd7gi 61 8 ’s ’s POS work_zbi2knhp65ho5n7vbsuthmd7gi 61 9 Balanced Balanced NNP work_zbi2knhp65ho5n7vbsuthmd7gi 61 10 Figure Figure NNP work_zbi2knhp65ho5n7vbsuthmd7gi 61 11   _SP work_zbi2knhp65ho5n7vbsuthmd7gi 61 12 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 61 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 61 14 amodiaquine amodiaquine RB work_zbi2knhp65ho5n7vbsuthmd7gi 61 15 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 61 16 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 61 17 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 61 18 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 61 19 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 61 20 alterations alteration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 61 21 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 61 22 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 61 23 malig- malig- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 61 24 nant nant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 61 25 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 61 26 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 61 27 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 62 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 62 2 A a NN work_zbi2knhp65ho5n7vbsuthmd7gi 62 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 62 4 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 62 5 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 62 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 62 7 a375 a375 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 62 8 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 62 9 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 62 10 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 62 11 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 62 12 1–20 1–20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 62 13 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 62 14 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 62 15 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 62 16 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 62 17 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 62 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 62 19 modu- modu- . work_zbi2knhp65ho5n7vbsuthmd7gi 62 20 lation lation NN work_zbi2knhp65ho5n7vbsuthmd7gi 62 21 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 62 22 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 62 23 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 62 24 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 62 25 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 62 26 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 62 27 Lc3-i/-ii Lc3-i/-ii NNP work_zbi2knhp65ho5n7vbsuthmd7gi 62 28 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 62 29 sQsTM1 sQsTM1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 62 30 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 62 31 BecN1 BecN1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 62 32 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 62 33 LaMP1 LaMP1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 62 34 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 62 35 sNca sNca NNP work_zbi2knhp65ho5n7vbsuthmd7gi 62 36 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 62 37 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 62 38 detected detect VBN work_zbi2knhp65ho5n7vbsuthmd7gi 62 39 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 62 40 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 62 41 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 62 42 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 62 43 loading loading NN work_zbi2knhp65ho5n7vbsuthmd7gi 62 44 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 62 45 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 62 46 acTB acTB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 62 47 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 62 48 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 63 1 Protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 63 2 adduction adduction NN work_zbi2knhp65ho5n7vbsuthmd7gi 63 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 63 4 unidentified unidentified JJ work_zbi2knhp65ho5n7vbsuthmd7gi 63 5 target target NN work_zbi2knhp65ho5n7vbsuthmd7gi 63 6 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 63 7 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 63 8 detected detect VBN work_zbi2knhp65ho5n7vbsuthmd7gi 63 9 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 63 10 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 63 11 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 63 12 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 63 13 directed direct VBN work_zbi2knhp65ho5n7vbsuthmd7gi 63 14 monoclonal monoclonal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 63 15 antibody antibody NN work_zbi2knhp65ho5n7vbsuthmd7gi 63 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 64 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 64 2 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 64 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 64 4 cellular cellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 64 5 autofluorescence autofluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 64 6 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 64 7 detected detect VBN work_zbi2knhp65ho5n7vbsuthmd7gi 64 8 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 64 9 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 64 10 cytometric cytometric NN work_zbi2knhp65ho5n7vbsuthmd7gi 64 11 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 64 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 65 1 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 65 2 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 65 3 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 65 4 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 65 5 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 65 6 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 65 7 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 65 8 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 65 9 24–48 24–48 CD work_zbi2knhp65ho5n7vbsuthmd7gi 65 10 h h NNP work_zbi2knhp65ho5n7vbsuthmd7gi 65 11 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 65 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 65 13 autofluorescence autofluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 65 14 intensity intensity NN work_zbi2knhp65ho5n7vbsuthmd7gi 65 15 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 65 16 a375 a375 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 65 17 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 65 18 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 65 19 quantified quantify VBN work_zbi2knhp65ho5n7vbsuthmd7gi 65 20 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 65 21 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 65 22 cytometry cytometry NN work_zbi2knhp65ho5n7vbsuthmd7gi 65 23 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 65 24 left leave VBD work_zbi2knhp65ho5n7vbsuthmd7gi 65 25 panel panel NN work_zbi2knhp65ho5n7vbsuthmd7gi 65 26 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 65 27 histogram histogram NNP work_zbi2knhp65ho5n7vbsuthmd7gi 65 28 representative representative NN work_zbi2knhp65ho5n7vbsuthmd7gi 65 29 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 65 30 three three CD work_zbi2knhp65ho5n7vbsuthmd7gi 65 31 similar similar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 65 32 repeats repeat NNS work_zbi2knhp65ho5n7vbsuthmd7gi 65 33 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 65 34 right right JJ work_zbi2knhp65ho5n7vbsuthmd7gi 65 35 panel panel NN work_zbi2knhp65ho5n7vbsuthmd7gi 65 36 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 65 37 bar bar NN work_zbi2knhp65ho5n7vbsuthmd7gi 65 38 graph graph NN work_zbi2knhp65ho5n7vbsuthmd7gi 65 39 summarizing summarizing NN work_zbi2knhp65ho5n7vbsuthmd7gi 65 40 data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 65 41 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 65 42 three three CD work_zbi2knhp65ho5n7vbsuthmd7gi 65 43 independent independent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 65 44 repeats repeat NNS work_zbi2knhp65ho5n7vbsuthmd7gi 65 45 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 65 46 n n NNP work_zbi2knhp65ho5n7vbsuthmd7gi 65 47 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 65 48 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 65 49 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 65 50 mean mean NNP work_zbi2knhp65ho5n7vbsuthmd7gi 65 51 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 65 52 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 65 53 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 65 54 D. D. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 66 1 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 66 2 P p NN work_zbi2knhp65ho5n7vbsuthmd7gi 66 3 < < XX work_zbi2knhp65ho5n7vbsuthmd7gi 66 4 0.05 0.05 XX work_zbi2knhp65ho5n7vbsuthmd7gi 66 5 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 66 6 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 66 7 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 67 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 67 2 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 67 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 67 4 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 67 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 67 6 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 67 7 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 67 8 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 67 9 examined examine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 67 10 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 67 11 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 67 12 metastatic metastatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 67 13 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 67 14 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 67 15 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 67 16 1–10 1–10 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 67 17 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 67 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 67 19 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 67 20 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 67 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 67 22 detected detect VBD work_zbi2knhp65ho5n7vbsuthmd7gi 67 23 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 67 24 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 67 25 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 67 26 A a NN work_zbi2knhp65ho5n7vbsuthmd7gi 67 27 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 67 28 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 68 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 68 2 D d NN work_zbi2knhp65ho5n7vbsuthmd7gi 68 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 68 4 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 68 5 flux flux NN work_zbi2knhp65ho5n7vbsuthmd7gi 68 6 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 68 7 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 68 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 68 9 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 68 10 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 68 11 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 68 12 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 68 13 Lc3 Lc3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 68 14 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 68 15 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 68 16 assay assay NN work_zbi2knhp65ho5n7vbsuthmd7gi 68 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 69 1 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 69 2 transfection transfection NN work_zbi2knhp65ho5n7vbsuthmd7gi 69 3 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 69 4 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 69 5 tandem tandem NN work_zbi2knhp65ho5n7vbsuthmd7gi 69 6 reporter reporter NN work_zbi2knhp65ho5n7vbsuthmd7gi 69 7 construct construct NN work_zbi2knhp65ho5n7vbsuthmd7gi 69 8 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 69 9 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 69 10 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 69 11 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 69 12 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 69 13 Lc3 Lc3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 69 14 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 69 15 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 69 16 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 69 17 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 69 18 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 69 19 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 69 20 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 69 21 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 69 22 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 69 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 69 24 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 69 25 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 69 26 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 69 27 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 69 28 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 69 29 colocalization colocalization NN work_zbi2knhp65ho5n7vbsuthmd7gi 69 30 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 69 31 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 69 32 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 69 33 Lc3 Lc3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 69 34 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 69 35 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 69 36 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 69 37 Lc3 Lc3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 69 38 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 69 39 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 69 40 examined examine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 69 41 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 69 42 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 69 43 microscopy microscopy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 69 44 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 70 1 Dual dual JJ work_zbi2knhp65ho5n7vbsuthmd7gi 70 2 fluorophore fluorophore NN work_zbi2knhp65ho5n7vbsuthmd7gi 70 3 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 70 4 labeled label VBN work_zbi2knhp65ho5n7vbsuthmd7gi 70 5 Lc3 lc3 NN work_zbi2knhp65ho5n7vbsuthmd7gi 70 6 transfectants transfectant NNS work_zbi2knhp65ho5n7vbsuthmd7gi 70 7 appear appear VBP work_zbi2knhp65ho5n7vbsuthmd7gi 70 8 yellow yellow JJ work_zbi2knhp65ho5n7vbsuthmd7gi 70 9 upon upon IN work_zbi2knhp65ho5n7vbsuthmd7gi 70 10 colocalization colocalization NN work_zbi2knhp65ho5n7vbsuthmd7gi 70 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 71 1 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 71 2 similar similar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 71 3 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 71 4 pattern pattern NN work_zbi2knhp65ho5n7vbsuthmd7gi 71 5 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 71 6 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 71 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 71 8 yellow yellow JJ work_zbi2knhp65ho5n7vbsuthmd7gi 71 9 fluorescent fluorescent NN work_zbi2knhp65ho5n7vbsuthmd7gi 71 10 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 71 11 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 71 12 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 71 13 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 71 14 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 71 15 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 71 16 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 71 17 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 71 18 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 71 19 proton proton NNP work_zbi2knhp65ho5n7vbsuthmd7gi 71 20 pump pump NN work_zbi2knhp65ho5n7vbsuthmd7gi 71 21 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 71 22 Bafa Bafa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 71 23 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 71 24 100 100 CD work_zbi2knhp65ho5n7vbsuthmd7gi 71 25 nM nM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 71 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 71 27 ≤ ≤ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 71 28 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 71 29 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 71 30 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 71 31 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 72 1 © © LS work_zbi2knhp65ho5n7vbsuthmd7gi 72 2 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 72 3 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 72 4 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 5 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 72 6 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 7 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 72 8 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 9 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 72 10 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 72 11 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 72 12 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 72 13 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 72 14 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 72 15 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 16 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 72 17 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 18 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 19 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 72 20 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 72 21 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 72 22 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 72 23 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 72 24 www.landesbioscience.com www.landesbioscience.com NNP work_zbi2knhp65ho5n7vbsuthmd7gi 72 25 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 72 26 2091 2091 CD work_zbi2knhp65ho5n7vbsuthmd7gi 72 27 Salt Salt NNP work_zbi2knhp65ho5n7vbsuthmd7gi 72 28 Solution Solution NNP work_zbi2knhp65ho5n7vbsuthmd7gi 72 29 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 72 30 HBSS HBSS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 72 31 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 72 32 causing cause VBG work_zbi2knhp65ho5n7vbsuthmd7gi 72 33 serum serum NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 34 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 72 35 amino amino JJ work_zbi2knhp65ho5n7vbsuthmd7gi 72 36 acid acid NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 37 starvation starvation NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 38 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 72 39 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 72 40 up up IN work_zbi2knhp65ho5n7vbsuthmd7gi 72 41 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 72 42 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 72 43 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 44 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 72 45 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 72 46 depletion depletion NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 47 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 72 48 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 72 49 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 72 50 substrate substrate NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 51 SQSTM1 SQSTM1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 72 52 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 72 53 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 72 54 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 72 55 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 72 56 observation observation NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 57 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 72 58 accordance accordance NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 59 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 72 60 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 72 61 established establish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 72 62 stimulatory stimulatory JJ work_zbi2knhp65ho5n7vbsuthmd7gi 72 63 effect effect NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 64 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 72 65 starvation starvation NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 66 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 72 67 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 72 68 activ- activ- NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 69 ity ity NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 70 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 72 71 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 72 72 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 73 1 4A 4A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 73 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 73 3 upper upper JJ work_zbi2knhp65ho5n7vbsuthmd7gi 73 4 panel panel NN work_zbi2knhp65ho5n7vbsuthmd7gi 73 5 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 73 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 74 1 This this DT work_zbi2knhp65ho5n7vbsuthmd7gi 74 2 starvation starvation NN work_zbi2knhp65ho5n7vbsuthmd7gi 74 3 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 74 4 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 74 5 depletion depletion NN work_zbi2knhp65ho5n7vbsuthmd7gi 74 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 74 7 SQSTM1 SQSTM1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 74 8 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 74 9 completely completely RB work_zbi2knhp65ho5n7vbsuthmd7gi 74 10 suppressed suppress VBN work_zbi2knhp65ho5n7vbsuthmd7gi 74 11 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 74 12 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 74 13 co co JJ work_zbi2knhp65ho5n7vbsuthmd7gi 74 14 - - NN work_zbi2knhp65ho5n7vbsuthmd7gi 74 15 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 74 16 suggesting suggest VBG work_zbi2knhp65ho5n7vbsuthmd7gi 74 17 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 74 18 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 74 19 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 74 20 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 74 21 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 74 22 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 74 23 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 74 24 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 74 25 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 74 26 interferes interfere VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 74 27 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 74 28 star- star- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 74 29 vation vation NN work_zbi2knhp65ho5n7vbsuthmd7gi 74 30 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 74 31 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 74 32 degradation degradation NN work_zbi2knhp65ho5n7vbsuthmd7gi 74 33 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 74 34 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 74 35 substrates substrate NNS work_zbi2knhp65ho5n7vbsuthmd7gi 74 36 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 74 37 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 74 38 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 75 1 4A 4A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 75 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 75 3 bottom bottom JJ work_zbi2knhp65ho5n7vbsuthmd7gi 75 4 panel panel NN work_zbi2knhp65ho5n7vbsuthmd7gi 75 5 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 75 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 76 1 We -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 76 2 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 76 3 observed observe VBD work_zbi2knhp65ho5n7vbsuthmd7gi 76 4 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 76 5 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 76 6 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 76 7 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 76 8 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 76 9 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 76 10 displayed display VBD work_zbi2knhp65ho5n7vbsuthmd7gi 76 11 early early JJ work_zbi2knhp65ho5n7vbsuthmd7gi 76 12 energy energy NN work_zbi2knhp65ho5n7vbsuthmd7gi 76 13 crisis crisis NN work_zbi2knhp65ho5n7vbsuthmd7gi 76 14 as as RB work_zbi2knhp65ho5n7vbsuthmd7gi 76 15 evident evident JJ work_zbi2knhp65ho5n7vbsuthmd7gi 76 16 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 76 17 sig- sig- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 76 18 nificant nificant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 76 19 depletion depletion NN work_zbi2knhp65ho5n7vbsuthmd7gi 76 20 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 76 21 cellular cellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 76 22 total total JJ work_zbi2knhp65ho5n7vbsuthmd7gi 76 23 ATP ATP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 76 24 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 76 25 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 76 26 occurred occur VBD work_zbi2knhp65ho5n7vbsuthmd7gi 76 27 as as RB work_zbi2knhp65ho5n7vbsuthmd7gi 76 28 early early RB work_zbi2knhp65ho5n7vbsuthmd7gi 76 29 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 76 30 within within IN work_zbi2knhp65ho5n7vbsuthmd7gi 76 31 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 76 32 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 76 33 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 76 34 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 76 35 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 76 36 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 77 1 4B 4B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 77 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 77 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 77 4 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 77 5 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 77 6 earlier early JJR work_zbi2knhp65ho5n7vbsuthmd7gi 77 7 reports report NNS work_zbi2knhp65ho5n7vbsuthmd7gi 77 8 indicating indicate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 77 9 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 77 10 ami- ami- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 77 11 noquinoline noquinoline NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 12 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 77 13 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 77 14 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 77 15 compromise compromise VB work_zbi2knhp65ho5n7vbsuthmd7gi 77 16 mito- mito- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 77 17 chondrial chondrial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 77 18 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 19 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 77 20 transmembrane transmembrane NNP work_zbi2knhp65ho5n7vbsuthmd7gi 77 21 potential.51,56 potential.51,56 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 77 22 Consistent Consistent NNP work_zbi2knhp65ho5n7vbsuthmd7gi 77 23 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 77 24 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 77 25 induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 26 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 77 27 energy energy NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 28 crisis crisis NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 29 due due JJ work_zbi2knhp65ho5n7vbsuthmd7gi 77 30 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 77 31 impairment impairment NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 32 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 77 33 mitochondrial mitochondrial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 77 34 function,57 function,57 NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 35 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 77 36 59 59 CD work_zbi2knhp65ho5n7vbsuthmd7gi 77 37 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 38 cyto- cyto- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 77 39 metric metric JJ work_zbi2knhp65ho5n7vbsuthmd7gi 77 40 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 41 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 77 42 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 77 43 sensor sensor NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 44 dye dye NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 45 JC-1 JC-1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 77 46 revealed reveal VBD work_zbi2knhp65ho5n7vbsuthmd7gi 77 47 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 77 48 moderate moderate JJ work_zbi2knhp65ho5n7vbsuthmd7gi 77 49 yet yet CC work_zbi2knhp65ho5n7vbsuthmd7gi 77 50 significant significant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 77 51 decrease decrease NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 52 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 77 53 mitochondrial mitochondrial NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 54 transmembrane transmembrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 55 potential potential NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 56 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 77 57 Δψm Δψm NNP work_zbi2knhp65ho5n7vbsuthmd7gi 77 58 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 77 59 observable observable JJ work_zbi2knhp65ho5n7vbsuthmd7gi 77 60 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 77 61 early early JJ work_zbi2knhp65ho5n7vbsuthmd7gi 77 62 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 63 points point NNS work_zbi2knhp65ho5n7vbsuthmd7gi 77 64 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 77 65 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 77 66 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 77 67 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 77 68 6 6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 77 69 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 70 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 77 71 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 77 72 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 78 1 4C 4c JJ work_zbi2knhp65ho5n7vbsuthmd7gi 78 2 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 78 3 top top JJ work_zbi2knhp65ho5n7vbsuthmd7gi 78 4 panels panel NNS work_zbi2knhp65ho5n7vbsuthmd7gi 78 5 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 78 6 bivari- bivari- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 78 7 ate eat VBD work_zbi2knhp65ho5n7vbsuthmd7gi 78 8 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 78 9 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 78 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 78 11 where where WRB work_zbi2knhp65ho5n7vbsuthmd7gi 78 12 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 78 13 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 78 14 diminished diminish VBD work_zbi2knhp65ho5n7vbsuthmd7gi 78 15 JC-1 JC-1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 78 16 red red JJ work_zbi2knhp65ho5n7vbsuthmd7gi 78 17 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 78 18 intensity intensity NN work_zbi2knhp65ho5n7vbsuthmd7gi 78 19 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 78 20 indicative indicative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 78 21 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 78 22 fully fully RB work_zbi2knhp65ho5n7vbsuthmd7gi 78 23 polar- polar- VBG work_zbi2knhp65ho5n7vbsuthmd7gi 78 24 ized ized JJ work_zbi2knhp65ho5n7vbsuthmd7gi 78 25 mitochondria mitochondria NNP work_zbi2knhp65ho5n7vbsuthmd7gi 78 26 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 78 27 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 78 28 approximately approximately RB work_zbi2knhp65ho5n7vbsuthmd7gi 78 29 25.0 25.0 CD work_zbi2knhp65ho5n7vbsuthmd7gi 78 30 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 78 31 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 78 32 con- con- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 78 33 trol trol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 78 34 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 78 35 1382.82 1382.82 CD work_zbi2knhp65ho5n7vbsuthmd7gi 78 36 ± ± CD work_zbi2knhp65ho5n7vbsuthmd7gi 78 37 76.40 76.40 CD work_zbi2knhp65ho5n7vbsuthmd7gi 78 38 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 78 39 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 78 40 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 78 41 1056.85 1056.85 CD work_zbi2knhp65ho5n7vbsuthmd7gi 78 42 ± ± CD work_zbi2knhp65ho5n7vbsuthmd7gi 78 43 34.68 34.68 CD work_zbi2knhp65ho5n7vbsuthmd7gi 78 44 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 78 45 n n CC work_zbi2knhp65ho5n7vbsuthmd7gi 78 46 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 78 47 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 78 48 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 78 49 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 78 50 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 79 1 4C 4c JJ work_zbi2knhp65ho5n7vbsuthmd7gi 79 2 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 79 3 bottom bottom JJ work_zbi2knhp65ho5n7vbsuthmd7gi 79 4 panel panel NN work_zbi2knhp65ho5n7vbsuthmd7gi 79 5 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 79 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 80 1 Importantly importantly RB work_zbi2knhp65ho5n7vbsuthmd7gi 80 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 80 3 even even RB work_zbi2knhp65ho5n7vbsuthmd7gi 80 4 upon upon IN work_zbi2knhp65ho5n7vbsuthmd7gi 80 5 lon- lon- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 80 6 ger g JJR work_zbi2knhp65ho5n7vbsuthmd7gi 80 7 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 80 8 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 80 9 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 80 10 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 80 11 further further JJ work_zbi2knhp65ho5n7vbsuthmd7gi 80 12 reduction reduction NN work_zbi2knhp65ho5n7vbsuthmd7gi 80 13 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 80 14 Δψm Δψm NNP work_zbi2knhp65ho5n7vbsuthmd7gi 80 15 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 80 16 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 80 17 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 80 18 data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 80 19 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 80 20 shown show VBN work_zbi2knhp65ho5n7vbsuthmd7gi 80 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 80 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 80 23 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 80 24 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 80 25 maintained maintain VBD work_zbi2knhp65ho5n7vbsuthmd7gi 80 26 full full JJ work_zbi2knhp65ho5n7vbsuthmd7gi 80 27 viability viability NN work_zbi2knhp65ho5n7vbsuthmd7gi 80 28 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 80 29 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 80 30 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 80 31 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 80 32 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 80 33 48 48 CD work_zbi2knhp65ho5n7vbsuthmd7gi 80 34 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 80 35 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 80 36 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 80 37 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 81 1 4D 4d LS work_zbi2knhp65ho5n7vbsuthmd7gi 81 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 81 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 82 1 Even even RB work_zbi2knhp65ho5n7vbsuthmd7gi 82 2 though though IN work_zbi2knhp65ho5n7vbsuthmd7gi 82 3 neither neither DT work_zbi2knhp65ho5n7vbsuthmd7gi 82 4 starvation starvation NN work_zbi2knhp65ho5n7vbsuthmd7gi 82 5 nor nor CC work_zbi2knhp65ho5n7vbsuthmd7gi 82 6 extended extended JJ work_zbi2knhp65ho5n7vbsuthmd7gi 82 7 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 82 8 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 82 9 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 82 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 82 11 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 82 12 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 82 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 82 14 48 48 CD work_zbi2knhp65ho5n7vbsuthmd7gi 82 15 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 82 16 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 82 17 diminished diminish VBD work_zbi2knhp65ho5n7vbsuthmd7gi 82 18 cellular cellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 82 19 viability viability NN work_zbi2knhp65ho5n7vbsuthmd7gi 82 20 if if IN work_zbi2knhp65ho5n7vbsuthmd7gi 82 21 adminis- adminis- NN work_zbi2knhp65ho5n7vbsuthmd7gi 82 22 tered tere VBN work_zbi2knhp65ho5n7vbsuthmd7gi 82 23 separately separately RB work_zbi2knhp65ho5n7vbsuthmd7gi 82 24 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 82 25 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 82 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 83 1 4D 4D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 83 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 83 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 83 4 pronounced pronounce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 83 5 induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 83 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 83 7 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 83 8 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 83 9 occurred occur VBD work_zbi2knhp65ho5n7vbsuthmd7gi 83 10 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 83 11 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 83 12 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 83 13 combination combination NN work_zbi2knhp65ho5n7vbsuthmd7gi 83 14 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 83 15 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 83 16 starvation starvation NN work_zbi2knhp65ho5n7vbsuthmd7gi 83 17 plus plus CC work_zbi2knhp65ho5n7vbsuthmd7gi 83 18 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 83 19 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 83 20 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 83 21 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 84 1 These these DT work_zbi2knhp65ho5n7vbsuthmd7gi 84 2 data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 84 3 strongly strongly RB work_zbi2knhp65ho5n7vbsuthmd7gi 84 4 suggest suggest VBP work_zbi2knhp65ho5n7vbsuthmd7gi 84 5 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 84 6 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 84 7 compromises compromise VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 84 8 mitochondrial mitochondrial NN work_zbi2knhp65ho5n7vbsuthmd7gi 84 9 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 84 10 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 84 11 blocks block VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 84 12 starvation starvation NN work_zbi2knhp65ho5n7vbsuthmd7gi 84 13 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 84 14 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 84 15 autophagic- autophagic- NN work_zbi2knhp65ho5n7vbsuthmd7gi 84 16 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 84 17 adaptations adaptation NNS work_zbi2knhp65ho5n7vbsuthmd7gi 84 18 thereby thereby RB work_zbi2knhp65ho5n7vbsuthmd7gi 84 19 sensitizing sensitize VBG work_zbi2knhp65ho5n7vbsuthmd7gi 84 20 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 84 21 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 84 22 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 84 23 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 84 24 cytotoxic cytotoxic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 84 25 metabolic metabolic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 84 26 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 84 27 imposed impose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 84 28 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 84 29 pro- pro- NN work_zbi2knhp65ho5n7vbsuthmd7gi 84 30 longed longed JJ work_zbi2knhp65ho5n7vbsuthmd7gi 84 31 starvation starvation NN work_zbi2knhp65ho5n7vbsuthmd7gi 84 32 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 85 1 Cumulative cumulative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 85 2 evidence evidence NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 3 suggests suggest VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 85 4 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 85 5 role role NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 85 7 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 85 8 dysregulation dysregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 9 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 85 10 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 11 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 12 resistance resistance NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 13 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 85 14 chemotherapeutic chemotherapeutic NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 15 agents.5,11,12 agents.5,11,12 NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 16 Based base VBN work_zbi2knhp65ho5n7vbsuthmd7gi 85 17 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 85 18 our -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 85 19 observation observation NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 20 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 85 21 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 85 22 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 85 23 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 85 24 potent potent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 85 25 inhibi- inhibi- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 85 26 tor tor NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 27 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 85 28 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 85 29 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 85 30 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 31 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 32 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 85 33 therefore therefore RB work_zbi2knhp65ho5n7vbsuthmd7gi 85 34 tested test VBD work_zbi2knhp65ho5n7vbsuthmd7gi 85 35 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 85 36 hypothesis hypothesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 37 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 85 38 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 85 39 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 85 40 sensitize sensitize VB work_zbi2knhp65ho5n7vbsuthmd7gi 85 41 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 42 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 85 43 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 85 44 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 85 45 cytotoxic cytotoxic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 85 46 action action NN work_zbi2knhp65ho5n7vbsuthmd7gi 85 47 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 85 48 standard standard JJ work_zbi2knhp65ho5n7vbsuthmd7gi 85 49 chemotherapeutics chemotherapeutic NNS work_zbi2knhp65ho5n7vbsuthmd7gi 85 50 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 86 1 Indeed indeed RB work_zbi2knhp65ho5n7vbsuthmd7gi 86 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 86 3 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 86 4 observed observe VBD work_zbi2knhp65ho5n7vbsuthmd7gi 86 5 that that DT work_zbi2knhp65ho5n7vbsuthmd7gi 86 6 cytotoxicity cytotoxicity NN work_zbi2knhp65ho5n7vbsuthmd7gi 86 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 86 8 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 86 9 chemotherapeutics chemotherapeutic NNS work_zbi2knhp65ho5n7vbsuthmd7gi 86 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 86 11 CDDP CDDP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 86 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 86 13 Doxo Doxo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 86 14 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 86 15 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 86 16 strongly strongly RB work_zbi2knhp65ho5n7vbsuthmd7gi 86 17 potentiated potentiate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 86 18 upon upon IN work_zbi2knhp65ho5n7vbsuthmd7gi 86 19 co co NN work_zbi2knhp65ho5n7vbsuthmd7gi 86 20 - - NN work_zbi2knhp65ho5n7vbsuthmd7gi 86 21 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 86 22 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 86 23 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 86 24 employed employ VBN work_zbi2knhp65ho5n7vbsuthmd7gi 86 25 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 86 26 con- con- NN work_zbi2knhp65ho5n7vbsuthmd7gi 86 27 centrations centration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 86 28 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 86 29 do do VBP work_zbi2knhp65ho5n7vbsuthmd7gi 86 30 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 86 31 impair impair VB work_zbi2knhp65ho5n7vbsuthmd7gi 86 32 viability viability NN work_zbi2knhp65ho5n7vbsuthmd7gi 86 33 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 86 34 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 86 35 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 86 36 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 86 37 if if IN work_zbi2knhp65ho5n7vbsuthmd7gi 86 38 used use VBN work_zbi2knhp65ho5n7vbsuthmd7gi 86 39 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 86 40 single single JJ work_zbi2knhp65ho5n7vbsuthmd7gi 86 41 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 86 42 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 86 43 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 86 44 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 87 1 4E 4E NNP work_zbi2knhp65ho5n7vbsuthmd7gi 87 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 87 3 F F NNP work_zbi2knhp65ho5n7vbsuthmd7gi 87 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 87 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 88 1 Specifically specifically RB work_zbi2knhp65ho5n7vbsuthmd7gi 88 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 88 3 when when WRB work_zbi2knhp65ho5n7vbsuthmd7gi 88 4 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 88 5 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 88 6 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 88 7 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 88 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 88 9 combined combine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 88 10 action action NN work_zbi2knhp65ho5n7vbsuthmd7gi 88 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 88 12 CDDP CDDP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 88 13 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 88 14 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 88 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 88 16 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 88 17 frac- frac- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 88 18 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 88 19 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 88 20 dead dead JJ work_zbi2knhp65ho5n7vbsuthmd7gi 88 21 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 88 22 increased increase VBD work_zbi2knhp65ho5n7vbsuthmd7gi 88 23 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 88 24 approximately approximately RB work_zbi2knhp65ho5n7vbsuthmd7gi 88 25 20.0 20.0 CD work_zbi2knhp65ho5n7vbsuthmd7gi 88 26 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 88 27 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 88 28 CDDP CDDP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 88 29 only only RB work_zbi2knhp65ho5n7vbsuthmd7gi 88 30 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 88 31 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 88 32 over over IN work_zbi2knhp65ho5n7vbsuthmd7gi 88 33 70.0 70.0 CD work_zbi2knhp65ho5n7vbsuthmd7gi 88 34 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 88 35 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 88 36 CDDP CDDP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 88 37 plus plus IN work_zbi2knhp65ho5n7vbsuthmd7gi 88 38 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 88 39 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 88 40 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 88 41 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 89 1 4E 4e LS work_zbi2knhp65ho5n7vbsuthmd7gi 89 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 89 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 90 1 Moreover moreover RB work_zbi2knhp65ho5n7vbsuthmd7gi 90 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 90 3 when when WRB work_zbi2knhp65ho5n7vbsuthmd7gi 90 4 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 90 5 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 90 6 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 90 7 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 90 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 90 9 combined combine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 90 10 action action NN work_zbi2knhp65ho5n7vbsuthmd7gi 90 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 90 12 Doxo Doxo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 90 13 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 90 14 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 90 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 90 16 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 90 17 Figure figure NN work_zbi2knhp65ho5n7vbsuthmd7gi 90 18   _SP work_zbi2knhp65ho5n7vbsuthmd7gi 90 19 3 3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 90 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 90 21 amodiaquine amodiaquine RB work_zbi2knhp65ho5n7vbsuthmd7gi 90 22 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 90 23 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 90 24 loss loss NN work_zbi2knhp65ho5n7vbsuthmd7gi 90 25 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 90 26 cathepsin cathepsin NN work_zbi2knhp65ho5n7vbsuthmd7gi 90 27 enzymatic enzymatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 90 28 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 90 29 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 90 30 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 90 31 malig- malig- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 90 32 nant nant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 90 33 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 90 34 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 90 35 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 91 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 91 2 A a DT work_zbi2knhp65ho5n7vbsuthmd7gi 91 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 91 4 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 91 5 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 91 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 91 7 Lc3-ii Lc3-ii NNP work_zbi2knhp65ho5n7vbsuthmd7gi 91 8 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 91 9 a375 a375 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 91 10 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 91 11 left leave VBD work_zbi2knhp65ho5n7vbsuthmd7gi 91 12 untreated untreated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 91 13 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 91 14 lane lane NNP work_zbi2knhp65ho5n7vbsuthmd7gi 91 15 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 91 16 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 91 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 91 18 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 91 19 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 91 20 Bafa Bafa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 91 21 only only RB work_zbi2knhp65ho5n7vbsuthmd7gi 91 22 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 91 23 100 100 CD work_zbi2knhp65ho5n7vbsuthmd7gi 91 24 nM nM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 91 25 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 91 26 4 4 CD work_zbi2knhp65ho5n7vbsuthmd7gi 91 27 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 91 28 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 91 29 h h NNS work_zbi2knhp65ho5n7vbsuthmd7gi 91 30 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 91 31 lanes lane NNS work_zbi2knhp65ho5n7vbsuthmd7gi 91 32 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 91 33 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 91 34 6 6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 91 35 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 91 36 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 91 37 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 91 38 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 91 39 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 91 40 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 91 41 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 91 42 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 91 43 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 91 44 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 91 45 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 91 46 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 91 47 absence absence NN work_zbi2knhp65ho5n7vbsuthmd7gi 91 48 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 91 49 lanes lanes NNP work_zbi2knhp65ho5n7vbsuthmd7gi 91 50 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 91 51 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 91 52 5 5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 91 53 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 91 54 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 91 55 presence presence NN work_zbi2knhp65ho5n7vbsuthmd7gi 91 56 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 91 57 Bafa Bafa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 91 58 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 91 59 lanes lanes NNP work_zbi2knhp65ho5n7vbsuthmd7gi 91 60 4 4 CD work_zbi2knhp65ho5n7vbsuthmd7gi 91 61 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 91 62 7 7 CD work_zbi2knhp65ho5n7vbsuthmd7gi 91 63 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 91 64 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 92 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 92 2 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 92 3 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 92 4 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 92 5 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 92 6 Loss Loss NNP work_zbi2knhp65ho5n7vbsuthmd7gi 92 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 92 8 cathepsin cathepsin NN work_zbi2knhp65ho5n7vbsuthmd7gi 92 9 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 92 10 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 92 11 enzymatic enzymatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 92 12 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 92 13 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 92 14 a375 a375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 92 15 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 92 16 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 92 17 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 92 18 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 92 19 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 92 20 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 92 21 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 92 22 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 92 23 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 92 24 exposed expose VBD work_zbi2knhp65ho5n7vbsuthmd7gi 92 25 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 92 26 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 92 27 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 92 28 1–20 1–20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 92 29 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 92 30 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 92 31 ≤ ≤ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 92 32 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 92 33 h h NNP work_zbi2knhp65ho5n7vbsuthmd7gi 92 34 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 92 35 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 92 36 detected detect VBN work_zbi2knhp65ho5n7vbsuthmd7gi 92 37 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 92 38 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 92 39 fluorimetric fluorimetric JJ work_zbi2knhp65ho5n7vbsuthmd7gi 92 40 assay assay NN work_zbi2knhp65ho5n7vbsuthmd7gi 92 41 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 93 1 Top top JJ work_zbi2knhp65ho5n7vbsuthmd7gi 93 2 panels panel NNS work_zbi2knhp65ho5n7vbsuthmd7gi 93 3 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 93 4 cTsB cTsB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 93 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 93 6 dose dose JJ work_zbi2knhp65ho5n7vbsuthmd7gi 93 7 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 93 8 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 93 9 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 93 10 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 93 11 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 93 12 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 93 13 middle middle JJ work_zbi2knhp65ho5n7vbsuthmd7gi 93 14 panels panel NNS work_zbi2knhp65ho5n7vbsuthmd7gi 93 15 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 93 16 cTsB cTsB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 93 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 93 18 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 93 19 course course NN work_zbi2knhp65ho5n7vbsuthmd7gi 93 20 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 93 21 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 93 22 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 93 23 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 93 24 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 93 25 bottom bottom JJ work_zbi2knhp65ho5n7vbsuthmd7gi 93 26 panels panel NNS work_zbi2knhp65ho5n7vbsuthmd7gi 93 27 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 93 28 cTsD cTsD NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 93 29 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 93 30 cTsL cTsL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 93 31 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 93 32 dose dose VBD work_zbi2knhp65ho5n7vbsuthmd7gi 93 33 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 93 34 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 93 35 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 93 36 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 93 37 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 93 38 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 94 1 Treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 94 2 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 94 3 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 94 4 cTsB cTsB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 94 5 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 94 6 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 94 7 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 94 8 ca074Me ca074Me . work_zbi2knhp65ho5n7vbsuthmd7gi 94 9 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 94 10 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 94 11 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 94 12 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 94 13 served serve VBD work_zbi2knhp65ho5n7vbsuthmd7gi 94 14 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 94 15 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 94 16 positive positive JJ work_zbi2knhp65ho5n7vbsuthmd7gi 94 17 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 94 18 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 94 19 n n NN work_zbi2knhp65ho5n7vbsuthmd7gi 94 20 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 94 21 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 94 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 94 23 mean mean NNP work_zbi2knhp65ho5n7vbsuthmd7gi 94 24 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 94 25 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 94 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 94 27 D. D. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 95 1 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 95 2 P p NN work_zbi2knhp65ho5n7vbsuthmd7gi 95 3 < < XX work_zbi2knhp65ho5n7vbsuthmd7gi 95 4 0.05 0.05 CD work_zbi2knhp65ho5n7vbsuthmd7gi 95 5 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 95 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 96 1 fraction fraction NN work_zbi2knhp65ho5n7vbsuthmd7gi 96 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 96 3 dead dead JJ work_zbi2knhp65ho5n7vbsuthmd7gi 96 4 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 96 5 increased increase VBD work_zbi2knhp65ho5n7vbsuthmd7gi 96 6 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 96 7 approximately approximately RB work_zbi2knhp65ho5n7vbsuthmd7gi 96 8 5.0 5.0 CD work_zbi2knhp65ho5n7vbsuthmd7gi 96 9 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 96 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 96 11 Doxo Doxo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 96 12 only only RB work_zbi2knhp65ho5n7vbsuthmd7gi 96 13 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 96 14 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 96 15 over over IN work_zbi2knhp65ho5n7vbsuthmd7gi 96 16 90.0 90.0 CD work_zbi2knhp65ho5n7vbsuthmd7gi 96 17 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 96 18 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 96 19 Doxo Doxo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 96 20 plus plus IN work_zbi2knhp65ho5n7vbsuthmd7gi 96 21 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 96 22 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 96 23 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 96 24 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 97 1 4F 4F NNP work_zbi2knhp65ho5n7vbsuthmd7gi 97 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 97 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 98 1 Gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 98 2 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 98 3 array array NN work_zbi2knhp65ho5n7vbsuthmd7gi 98 4 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 98 5 reveals reveal VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 98 6 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 98 7 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 98 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 98 9 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 98 10 pro- pro- NN work_zbi2knhp65ho5n7vbsuthmd7gi 98 11 liferative liferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 98 12 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 98 13 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 98 14 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 98 15 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 98 16 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 98 17 To to TO work_zbi2knhp65ho5n7vbsuthmd7gi 98 18 gain gain VB work_zbi2knhp65ho5n7vbsuthmd7gi 98 19 further further JJ work_zbi2knhp65ho5n7vbsuthmd7gi 98 20 mechanistic mechanistic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 98 21 insight insight NN work_zbi2knhp65ho5n7vbsuthmd7gi 98 22 into into IN work_zbi2knhp65ho5n7vbsuthmd7gi 98 23 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 98 24 molecular molecular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 98 25 events event NNS work_zbi2knhp65ho5n7vbsuthmd7gi 98 26 underlying underlie VBG work_zbi2knhp65ho5n7vbsuthmd7gi 98 27 antimelanoma antimelanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 98 28 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 98 29 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 98 30 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 98 31 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 98 32 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 98 33 performed perform VBD work_zbi2knhp65ho5n7vbsuthmd7gi 98 34 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 98 35 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 98 36 array array NNP work_zbi2knhp65ho5n7vbsuthmd7gi 98 37 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 98 38 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 99 1 To to IN work_zbi2knhp65ho5n7vbsuthmd7gi 99 2 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 99 3 end end NN work_zbi2knhp65ho5n7vbsuthmd7gi 99 4 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 99 5 modulation modulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 99 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 99 7 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 99 8 expres- expres- VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 99 9 sion sion NN work_zbi2knhp65ho5n7vbsuthmd7gi 99 10 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 99 11 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 99 12 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 99 13 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 99 14 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 99 15 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 99 16 25 25 CD work_zbi2knhp65ho5n7vbsuthmd7gi 99 17 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 99 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 99 19 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 99 20 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 99 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 99 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 99 23 vs. vs. IN work_zbi2knhp65ho5n7vbsuthmd7gi 99 24 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 99 25 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 99 26 assessed assess VBN work_zbi2knhp65ho5n7vbsuthmd7gi 99 27 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 99 28 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 99 29 PCR PCR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 99 30 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 99 31 based base VBN work_zbi2knhp65ho5n7vbsuthmd7gi 99 32 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 99 33 array array NN work_zbi2knhp65ho5n7vbsuthmd7gi 99 34 system system NN work_zbi2knhp65ho5n7vbsuthmd7gi 99 35 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 100 1 Out out IN work_zbi2knhp65ho5n7vbsuthmd7gi 100 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 100 3 168 168 CD work_zbi2knhp65ho5n7vbsuthmd7gi 100 4 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 100 5 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 100 6 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 100 7 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 100 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 100 9 related relate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 100 10 genes gene NNS work_zbi2knhp65ho5n7vbsuthmd7gi 100 11 contained contain VBN work_zbi2knhp65ho5n7vbsuthmd7gi 100 12 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 100 13 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 100 14 com- com- NN work_zbi2knhp65ho5n7vbsuthmd7gi 100 15 bined bin VBN work_zbi2knhp65ho5n7vbsuthmd7gi 100 16 array array NN work_zbi2knhp65ho5n7vbsuthmd7gi 100 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 100 18 25 25 CD work_zbi2knhp65ho5n7vbsuthmd7gi 100 19 genes gene NNS work_zbi2knhp65ho5n7vbsuthmd7gi 100 20 displayed display VBD work_zbi2knhp65ho5n7vbsuthmd7gi 100 21 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 100 22 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 100 23 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 100 24 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 100 25 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 100 26 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 100 27 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 100 28 mRNA mrna JJ work_zbi2knhp65ho5n7vbsuthmd7gi 100 29 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 100 30 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 100 31 at at RB work_zbi2knhp65ho5n7vbsuthmd7gi 100 32 least least JJS work_zbi2knhp65ho5n7vbsuthmd7gi 100 33 2-fold 2-fold CD work_zbi2knhp65ho5n7vbsuthmd7gi 100 34 over over IN work_zbi2knhp65ho5n7vbsuthmd7gi 100 35 untreated untreated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 100 36 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 100 37 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 100 38 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 100 39 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 100 40 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 101 1 5A 5a RB work_zbi2knhp65ho5n7vbsuthmd7gi 101 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 101 3 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 101 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 101 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 102 1 Strikingly strikingly RB work_zbi2knhp65ho5n7vbsuthmd7gi 102 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 102 3 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 102 4 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 5 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 102 6 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 102 7 © © NNP work_zbi2knhp65ho5n7vbsuthmd7gi 102 8 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 102 9 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 102 10 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 11 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 102 12 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 13 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 102 14 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 15 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 102 16 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 102 17 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 102 18 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 102 19 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 102 20 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 102 21 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 22 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 102 23 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 24 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 25 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 102 26 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 102 27 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 102 28 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 102 29 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 102 30 2092 2092 CD work_zbi2knhp65ho5n7vbsuthmd7gi 102 31 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 102 32 Volume Volume NNP work_zbi2knhp65ho5n7vbsuthmd7gi 102 33 9 9 CD work_zbi2knhp65ho5n7vbsuthmd7gi 102 34 issue issue NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 35 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 102 36 modulation modulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 37 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 102 38 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 39 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 40 antagonizing antagonize VBG work_zbi2knhp65ho5n7vbsuthmd7gi 102 41 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 42 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 43 progres- progres- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 102 44 sion sion NN work_zbi2knhp65ho5n7vbsuthmd7gi 102 45 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 103 1 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 103 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 103 3 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 103 4 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 103 5 encoding encode VBG work_zbi2knhp65ho5n7vbsuthmd7gi 103 6 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 103 7 transcription transcription NN work_zbi2knhp65ho5n7vbsuthmd7gi 103 8 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 103 9 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 103 10 master master NN work_zbi2knhp65ho5n7vbsuthmd7gi 103 11 regulator regulator NN work_zbi2knhp65ho5n7vbsuthmd7gi 103 12 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 103 13 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 103 14 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 103 15 /S /S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 103 16 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 103 17 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 103 18 transition transition NN work_zbi2knhp65ho5n7vbsuthmd7gi 103 19 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 103 20 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 103 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 103 22 displayed display VBD work_zbi2knhp65ho5n7vbsuthmd7gi 103 23 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 103 24 highest high JJS work_zbi2knhp65ho5n7vbsuthmd7gi 103 25 negative negative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 103 26 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 103 27 differential differential NN work_zbi2knhp65ho5n7vbsuthmd7gi 103 28 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 103 29 6.7-fold 6.7-fold CD work_zbi2knhp65ho5n7vbsuthmd7gi 103 30 downregulation downregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 103 31 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 103 32 elicited elicit VBN work_zbi2knhp65ho5n7vbsuthmd7gi 103 33 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 103 34 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 103 35 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 104 1 Conversely conversely RB work_zbi2knhp65ho5n7vbsuthmd7gi 104 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 104 3 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 104 5 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 104 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 104 7 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 104 8 TP53-controlled tp53-controlle VBN work_zbi2knhp65ho5n7vbsuthmd7gi 104 9 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 10 encoding encode VBG work_zbi2knhp65ho5n7vbsuthmd7gi 104 11 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 104 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 104 13 cyclin cyclin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 104 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 104 15 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 104 16 kinase kinase NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 17 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 18 1A 1a CD work_zbi2knhp65ho5n7vbsuthmd7gi 104 19 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 104 20 p21 p21 NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 104 22 Cip1 Cip1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 104 23 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 104 24 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 104 25 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 104 26 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 104 27 negative negative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 104 28 regulator regulator NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 29 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 104 30 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 31 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 32 progression progression NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 33 caus- caus- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 104 34 ing ing NNP work_zbi2knhp65ho5n7vbsuthmd7gi 104 35 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 104 36 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 104 37 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 104 38 G g NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 39 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 104 40 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 104 41 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 104 42 S s NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 43 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 104 44 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 45 arrest,60 arrest,60 NN work_zbi2knhp65ho5n7vbsuthmd7gi 104 46 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 104 47 upregulated upregulate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 104 48 significantly significantly RB work_zbi2knhp65ho5n7vbsuthmd7gi 104 49 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 104 50 4.2-fold 4.2-fold CD work_zbi2knhp65ho5n7vbsuthmd7gi 104 51 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 104 52 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 105 1 Subsequent subsequent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 105 2 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 105 3 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 105 4 confirmed confirm VBD work_zbi2knhp65ho5n7vbsuthmd7gi 105 5 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 105 6 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 105 7 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 105 8 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 105 9 changes change VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 105 10 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 105 11 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 105 12 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 105 13 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 105 14 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 105 15 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 105 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 105 17 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 105 18 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 105 19 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 105 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 106 1 6A 6a NN work_zbi2knhp65ho5n7vbsuthmd7gi 106 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 106 3 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 106 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 106 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 106 6 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 106 7 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 106 8 dose dose JJ work_zbi2knhp65ho5n7vbsuthmd7gi 106 9 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 106 10 relationship relationship NN work_zbi2knhp65ho5n7vbsuthmd7gi 106 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 106 12 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 106 13 mRNA mrna NN work_zbi2knhp65ho5n7vbsuthmd7gi 106 14 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 106 15 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 106 16 established establish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 106 17 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 106 18 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 106 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 107 1 6C 6c NN work_zbi2knhp65ho5n7vbsuthmd7gi 107 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 107 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 108 1 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 108 2 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 108 3 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 108 4 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 108 5 negative negative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 108 6 modulation modulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 108 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 108 8 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 108 9 broad broad JJ work_zbi2knhp65ho5n7vbsuthmd7gi 108 10 array array NN work_zbi2knhp65ho5n7vbsuthmd7gi 108 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 108 12 genes gene NNS work_zbi2knhp65ho5n7vbsuthmd7gi 108 13 encoding encode VBG work_zbi2knhp65ho5n7vbsuthmd7gi 108 14 heat heat NN work_zbi2knhp65ho5n7vbsuthmd7gi 108 15 shock shock NN work_zbi2knhp65ho5n7vbsuthmd7gi 108 16 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 108 17 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 108 18 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 108 19 HSPA8 hspa8 UH work_zbi2knhp65ho5n7vbsuthmd7gi 108 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 108 21 HSPA1A hspa1a UH work_zbi2knhp65ho5n7vbsuthmd7gi 108 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 108 23 HSP90AA1 HSP90AA1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 108 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 108 25 HSPCA HSPCA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 108 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 108 27 HSPA2 HSPA2 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 108 28 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 108 29 HSPA1L HSPA1L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 108 30 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 108 31 DNAJA1 DNAJA1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 108 32 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 108 33 CRYAB),61 CRYAB),61 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 108 34 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 108 35 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 108 36 dose dose JJ work_zbi2knhp65ho5n7vbsuthmd7gi 108 37 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 108 38 relationship relationship NN work_zbi2knhp65ho5n7vbsuthmd7gi 108 39 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 108 40 HSPA1A hspa1a CD work_zbi2knhp65ho5n7vbsuthmd7gi 108 41 mRNA mRNA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 108 42 downregulation downregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 108 43 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 108 44 established establish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 108 45 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 108 46 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 108 47 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 109 1 6C 6c NN work_zbi2knhp65ho5n7vbsuthmd7gi 109 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 109 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 110 1 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 110 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 110 3 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 110 4 suppres- suppres- NN work_zbi2knhp65ho5n7vbsuthmd7gi 110 5 sion sion NN work_zbi2knhp65ho5n7vbsuthmd7gi 110 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 110 7 heat heat NN work_zbi2knhp65ho5n7vbsuthmd7gi 110 8 shock shock NN work_zbi2knhp65ho5n7vbsuthmd7gi 110 9 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 110 10 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 110 11 encoding encode VBG work_zbi2knhp65ho5n7vbsuthmd7gi 110 12 genes gene NNS work_zbi2knhp65ho5n7vbsuthmd7gi 110 13 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 110 14 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 110 15 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 110 16 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 110 17 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 110 18 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 110 19 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 110 20 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 110 21 HSPA1A hspa1a UH work_zbi2knhp65ho5n7vbsuthmd7gi 110 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 110 23 HSP90AA1 hsp90aa1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 110 24 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 110 25 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 110 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 111 1 6A 6a NN work_zbi2knhp65ho5n7vbsuthmd7gi 111 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 111 3 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 111 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 111 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 112 1 Pharmacological pharmacological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 2 downregulation downregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 4 heat heat NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 5 shock shock NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 6 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 7 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 8 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 9 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 112 10 expected expect VBN work_zbi2knhp65ho5n7vbsuthmd7gi 112 11 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 112 12 increase increase VB work_zbi2knhp65ho5n7vbsuthmd7gi 112 13 proteotoxic proteotoxic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 14 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 112 16 particularly particularly RB work_zbi2knhp65ho5n7vbsuthmd7gi 112 17 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 18 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 19 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 112 20 constitutively constitutively RB work_zbi2knhp65ho5n7vbsuthmd7gi 112 21 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 112 22 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 23 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 112 24 high high JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 25 unfolded unfold VBN work_zbi2knhp65ho5n7vbsuthmd7gi 112 26 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 27 burden.62,63 burden.62,63 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 112 28 Indeed indeed RB work_zbi2knhp65ho5n7vbsuthmd7gi 112 29 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 112 30 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 31 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 32 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 112 33 suppression suppression NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 34 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 35 heat heat NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 36 shock shock NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 37 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 38 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 39 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 40 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 41 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 42 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 112 43 array array NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 44 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 45 indicated indicate VBD work_zbi2knhp65ho5n7vbsuthmd7gi 112 46 tran- tran- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 47 scriptional scriptional JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 48 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 49 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 50 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 112 51 ER ER NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 52 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 53 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 54 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 55 DDIT3 DDIT3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 56 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 112 57 6.1 6.1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 112 58 fold fold VB work_zbi2knhp65ho5n7vbsuthmd7gi 112 59 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 112 60 encoding encode VBG work_zbi2knhp65ho5n7vbsuthmd7gi 112 61 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 112 62 transcription transcription NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 63 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 64 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 112 65 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 112 66 known know VBN work_zbi2knhp65ho5n7vbsuthmd7gi 112 67 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 68 CHOP/ CHOP/ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 69 GADD153 GADD153 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 70 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 112 71 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 112 72 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 112 73 common common JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 74 marker marker NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 75 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 76 proteotoxic proteotoxic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 77 stress.64 stress.64 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 78 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 79 addition addition NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 80 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 112 81 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 82 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 83 other other JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 84 genes gene NNS work_zbi2knhp65ho5n7vbsuthmd7gi 112 85 responsive responsive JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 86 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 87 vari- vari- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 88 ous ous JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 89 types type NNS work_zbi2knhp65ho5n7vbsuthmd7gi 112 90 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 91 cytotoxic cytotoxic NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 92 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 93 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 112 94 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 112 95 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 112 96 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 97 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 112 98 treated treat VBN work_zbi2knhp65ho5n7vbsuthmd7gi 112 99 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 100 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 112 101 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 112 102 GADD45A GADD45A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 103 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 112 104 encoding encode VBG work_zbi2knhp65ho5n7vbsuthmd7gi 112 105 growth growth NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 106 arrest arrest NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 107 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 112 108 DNA- DNA- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 109 damage damage NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 110 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 112 111 inducible inducible JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 112 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 112 113 α α XX work_zbi2knhp65ho5n7vbsuthmd7gi 112 114 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 112 115 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 112 116 TP53-regulated tp53-regulated CD work_zbi2knhp65ho5n7vbsuthmd7gi 112 117 DNA dna NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 118 damage damage NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 119 induc- induc- NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 120 ible ible JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 121 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 122 sensor sensor NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 123 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 112 124 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 112 125 EGR1 EGR1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 126 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 112 127 encoding encode VBG work_zbi2knhp65ho5n7vbsuthmd7gi 112 128 early early JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 129 growth growth NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 130 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 131 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 112 132 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 112 133 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 112 134 oxidative oxidative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 135 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 136 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 112 137 sensitive sensitive JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 138 transcription transcription NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 139 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 140 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 112 141 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 112 142 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 112 143 TP53 TP53 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 144 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 112 145 encoding encode VBG work_zbi2knhp65ho5n7vbsuthmd7gi 112 146 tumor tumor NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 147 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 148 p53 p53 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 149 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 112 150 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 112 151 genotoxic genotoxic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 152 stress- stress- NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 153 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 112 154 general general JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 155 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 156 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 112 157 responsive responsive JJ work_zbi2knhp65ho5n7vbsuthmd7gi 112 158 tumor tumor NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 159 suppressor suppressor NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 160 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 112 161 transcription transcription NNP work_zbi2knhp65ho5n7vbsuthmd7gi 112 162 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 112 163 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 112 164 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 113 1 Importantly importantly RB work_zbi2knhp65ho5n7vbsuthmd7gi 113 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 113 3 pronounced pronounce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 113 4 TP53 tp53 IN work_zbi2knhp65ho5n7vbsuthmd7gi 113 5 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 113 6 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 113 7 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 113 8 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 113 9 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 113 10 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 113 11 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 113 12 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 113 13 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 113 14 TP53 tp53 IN work_zbi2knhp65ho5n7vbsuthmd7gi 113 15 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 113 16 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 113 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 114 1 6A 6a NN work_zbi2knhp65ho5n7vbsuthmd7gi 114 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 114 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 114 4 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 114 5 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 114 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 114 7 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 114 8 TP53 TP53 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 114 9 target target NN work_zbi2knhp65ho5n7vbsuthmd7gi 114 10 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 114 11 GDF15 GDF15 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 114 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 114 13 encoding encode VBG work_zbi2knhp65ho5n7vbsuthmd7gi 114 14 growth growth NN work_zbi2knhp65ho5n7vbsuthmd7gi 114 15 differentiation differentiation NN work_zbi2knhp65ho5n7vbsuthmd7gi 114 16 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 114 17 Figure Figure NNP work_zbi2knhp65ho5n7vbsuthmd7gi 114 18   _SP work_zbi2knhp65ho5n7vbsuthmd7gi 114 19 4 4 CD work_zbi2knhp65ho5n7vbsuthmd7gi 114 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 114 21 amodiaquine amodiaquine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 114 22 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 114 23 rapid rapid JJ work_zbi2knhp65ho5n7vbsuthmd7gi 114 24 aTP aTP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 114 25 depletion depletion NN work_zbi2knhp65ho5n7vbsuthmd7gi 114 26 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 114 27 sensitization sensitization NN work_zbi2knhp65ho5n7vbsuthmd7gi 114 28 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 114 29 starvation- starvation- NN work_zbi2knhp65ho5n7vbsuthmd7gi 114 30 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 114 31 chemotherapeutic chemotherapeutic RB work_zbi2knhp65ho5n7vbsuthmd7gi 114 32 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 114 33 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 114 34 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 114 35 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 114 36 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 115 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 115 2 A a NN work_zbi2knhp65ho5n7vbsuthmd7gi 115 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 115 4 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 115 5 modulation modulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 115 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 115 7 starvation starvation NN work_zbi2knhp65ho5n7vbsuthmd7gi 115 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 115 9 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 115 10 sQsTM1 sQsTM1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 115 11 depletion depletion NN work_zbi2knhp65ho5n7vbsuthmd7gi 115 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 116 1 a375 a375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 116 2 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 116 3 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 116 4 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 116 5 cultured culture VBN work_zbi2knhp65ho5n7vbsuthmd7gi 116 6 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 116 7 hBss hBss NNP work_zbi2knhp65ho5n7vbsuthmd7gi 116 8 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 116 9 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 116 10 presence presence NN work_zbi2knhp65ho5n7vbsuthmd7gi 116 11 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 116 12 absence absence NN work_zbi2knhp65ho5n7vbsuthmd7gi 116 13 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 116 14 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 116 15 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 116 16 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 116 17 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 116 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 116 19 1–24 1–24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 116 20 h h NNP work_zbi2knhp65ho5n7vbsuthmd7gi 116 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 116 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 117 1 Protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 117 2 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 117 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 117 4 sQsTM1 sQsTM1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 117 5 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 117 6 determined determine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 117 7 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 117 8 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 117 9 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 117 10 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 117 11 acTB acTB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 117 12 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 117 13 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 117 14 loading loading NN work_zbi2knhp65ho5n7vbsuthmd7gi 117 15 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 117 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 118 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 118 2 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 118 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 118 4 early early RB work_zbi2knhp65ho5n7vbsuthmd7gi 118 5 cellular cellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 118 6 aTP atp JJ work_zbi2knhp65ho5n7vbsuthmd7gi 118 7 depletion depletion NN work_zbi2knhp65ho5n7vbsuthmd7gi 118 8 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 118 9 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 118 10 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 118 11 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 118 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 118 13 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 118 14 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 118 15 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 118 16 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 118 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 118 18 ≤ ≤ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 118 19 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 118 20 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 118 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 118 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 119 1 Data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 119 2 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 119 3 expressed express VBN work_zbi2knhp65ho5n7vbsuthmd7gi 119 4 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 119 5 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 119 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 119 7 untreated untreated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 119 8 controls control NNS work_zbi2knhp65ho5n7vbsuthmd7gi 119 9 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 119 10 mean mean NNP work_zbi2knhp65ho5n7vbsuthmd7gi 119 11 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 119 12 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 119 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 119 14 D. D. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 120 1 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 120 2 n n LS work_zbi2knhp65ho5n7vbsuthmd7gi 120 3 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 120 4 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 120 5 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 120 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 121 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 121 2 C c NN work_zbi2knhp65ho5n7vbsuthmd7gi 121 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 121 4 alteration alteration NN work_zbi2knhp65ho5n7vbsuthmd7gi 121 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 121 6 mitochondrial mitochondrial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 121 7 transmembrane transmembrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 121 8 potential potential NN work_zbi2knhp65ho5n7vbsuthmd7gi 121 9 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 121 10 Δψm Δψm NNP work_zbi2knhp65ho5n7vbsuthmd7gi 121 11 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 121 12 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 121 13 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 121 14 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 121 15 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 121 16 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 121 17 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 121 18 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 121 19 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 121 20 6 6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 121 21 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 121 22 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 121 23 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 121 24 assessed assess VBN work_zbi2knhp65ho5n7vbsuthmd7gi 121 25 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 121 26 bivariate bivariate JJ work_zbi2knhp65ho5n7vbsuthmd7gi 121 27 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 121 28 cytometric cytometric NN work_zbi2knhp65ho5n7vbsuthmd7gi 121 29 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 121 30 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 121 31 Jc-1-stained Jc-1-stained NNP work_zbi2knhp65ho5n7vbsuthmd7gi 121 32 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 121 33 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 122 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 122 2 upper upper JJ work_zbi2knhp65ho5n7vbsuthmd7gi 122 3 two two CD work_zbi2knhp65ho5n7vbsuthmd7gi 122 4 panels panel NNS work_zbi2knhp65ho5n7vbsuthmd7gi 122 5 display display VBP work_zbi2knhp65ho5n7vbsuthmd7gi 122 6 one one CD work_zbi2knhp65ho5n7vbsuthmd7gi 122 7 representative representative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 122 8 experiment experiment NN work_zbi2knhp65ho5n7vbsuthmd7gi 122 9 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 122 10 three three CD work_zbi2knhp65ho5n7vbsuthmd7gi 122 11 similar similar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 122 12 repeats repeat NNS work_zbi2knhp65ho5n7vbsuthmd7gi 122 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 122 14 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 122 15 numbers number NNS work_zbi2knhp65ho5n7vbsuthmd7gi 122 16 indicate indicate VBP work_zbi2knhp65ho5n7vbsuthmd7gi 122 17 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 122 18 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 122 19 impaired impaired JJ work_zbi2knhp65ho5n7vbsuthmd7gi 122 20 Δψm Δψm NNP work_zbi2knhp65ho5n7vbsuthmd7gi 122 21 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 122 22 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 122 23 percent percent NN work_zbi2knhp65ho5n7vbsuthmd7gi 122 24 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 122 25 total total JJ work_zbi2knhp65ho5n7vbsuthmd7gi 122 26 gated gate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 122 27 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 122 28 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 122 29 detected detect VBD work_zbi2knhp65ho5n7vbsuthmd7gi 122 30 outside outside IN work_zbi2knhp65ho5n7vbsuthmd7gi 122 31 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 122 32 circle circle NN work_zbi2knhp65ho5n7vbsuthmd7gi 122 33 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 122 34 mean mean VB work_zbi2knhp65ho5n7vbsuthmd7gi 122 35 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 122 36 sD sD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 122 37 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 122 38 n n NN work_zbi2knhp65ho5n7vbsuthmd7gi 122 39 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 122 40 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 122 41 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 122 42 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 123 1 Lower low JJR work_zbi2knhp65ho5n7vbsuthmd7gi 123 2 panel panel NN work_zbi2knhp65ho5n7vbsuthmd7gi 123 3 displays display NNS work_zbi2knhp65ho5n7vbsuthmd7gi 123 4 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 123 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 123 6 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 123 7 alteration alteration NN work_zbi2knhp65ho5n7vbsuthmd7gi 123 8 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 123 9 Jc-1 Jc-1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 123 10 red red NNP work_zbi2knhp65ho5n7vbsuthmd7gi 123 11 fluorescence fluorescence NNP work_zbi2knhp65ho5n7vbsuthmd7gi 123 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 123 13 polarized polarize VBD work_zbi2knhp65ho5n7vbsuthmd7gi 123 14 mitochondria mitochondria NNP work_zbi2knhp65ho5n7vbsuthmd7gi 123 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 123 16 detector detector NN work_zbi2knhp65ho5n7vbsuthmd7gi 123 17 FL-2 FL-2 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 123 18 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 123 19 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 123 20 representative representative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 123 21 experiment experiment NN work_zbi2knhp65ho5n7vbsuthmd7gi 123 22 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 123 23 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 123 24 similar similar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 123 25 repeats repeat NNS work_zbi2knhp65ho5n7vbsuthmd7gi 123 26 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 123 27 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 124 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 124 2 D d NN work_zbi2knhp65ho5n7vbsuthmd7gi 124 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 124 4 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 124 5 viability viability NN work_zbi2knhp65ho5n7vbsuthmd7gi 124 6 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 124 7 determined determine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 124 8 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 124 9 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 124 10 cytometric cytometric NN work_zbi2knhp65ho5n7vbsuthmd7gi 124 11 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 124 12 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 124 13 aNXa5-FiTc anxa5-fitc CD work_zbi2knhp65ho5n7vbsuthmd7gi 124 14 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 124 15 Pi Pi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 124 16 staining stain VBG work_zbi2knhp65ho5n7vbsuthmd7gi 124 17 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 124 18 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 124 19 cultured culture VBN work_zbi2knhp65ho5n7vbsuthmd7gi 124 20 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 124 21 hBss hBss NNP work_zbi2knhp65ho5n7vbsuthmd7gi 124 22 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 124 23 standard standard JJ work_zbi2knhp65ho5n7vbsuthmd7gi 124 24 medium medium NN work_zbi2knhp65ho5n7vbsuthmd7gi 124 25 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 124 26 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 124 27 presence presence NN work_zbi2knhp65ho5n7vbsuthmd7gi 124 28 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 124 29 absence absence NN work_zbi2knhp65ho5n7vbsuthmd7gi 124 30 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 124 31 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 124 32 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 124 33 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 124 34 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 124 35 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 124 36 48 48 CD work_zbi2knhp65ho5n7vbsuthmd7gi 124 37 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 124 38 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 124 39 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 125 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 125 2 numbers number NNS work_zbi2knhp65ho5n7vbsuthmd7gi 125 3 indicate indicate VBP work_zbi2knhp65ho5n7vbsuthmd7gi 125 4 viable viable JJ work_zbi2knhp65ho5n7vbsuthmd7gi 125 5 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 125 6 aNXa5-/Pi- aNXa5-/Pi- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 125 7 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 125 8 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 125 9 percent percent NN work_zbi2knhp65ho5n7vbsuthmd7gi 125 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 125 11 total total JJ work_zbi2knhp65ho5n7vbsuthmd7gi 125 12 gated gate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 125 13 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 125 14 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 125 15 mean mean NNP work_zbi2knhp65ho5n7vbsuthmd7gi 125 16 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 125 17 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 125 18 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 125 19 D. D. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 126 1 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 126 2 n n LS work_zbi2knhp65ho5n7vbsuthmd7gi 126 3 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 126 4 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 126 5 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 126 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 127 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 127 2 E e NN work_zbi2knhp65ho5n7vbsuthmd7gi 127 3 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 127 4 F f NN work_zbi2knhp65ho5n7vbsuthmd7gi 127 5 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 127 6 chemosensitization chemosensitization NN work_zbi2knhp65ho5n7vbsuthmd7gi 127 7 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 127 8 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 127 9 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 127 10 examined examine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 127 11 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 127 12 a375 a375 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 127 13 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 127 14 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 127 15 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 127 16 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 127 17 combined combine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 127 18 action action NN work_zbi2knhp65ho5n7vbsuthmd7gi 127 19 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 127 20 cisplatin cisplatin NN work_zbi2knhp65ho5n7vbsuthmd7gi 127 21 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 127 22 cPPD cPPD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 127 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 127 24 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 127 25 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 127 26 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 127 27 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 127 28 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 127 29 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 127 30 D d NN work_zbi2knhp65ho5n7vbsuthmd7gi 127 31 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 127 32 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 127 33 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 127 34 doxorubicin doxorubicin NNS work_zbi2knhp65ho5n7vbsuthmd7gi 127 35 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 127 36 Doxo Doxo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 127 37 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 127 38 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 127 39 nM nM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 127 40 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 127 41 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 127 42 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 127 43 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 127 44 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 127 45 E e NN work_zbi2knhp65ho5n7vbsuthmd7gi 127 46 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 127 47 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 127 48 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 127 49 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 127 50 without without IN work_zbi2knhp65ho5n7vbsuthmd7gi 127 51 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 127 52 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 127 53 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 127 54 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 127 55 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 127 56 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 127 57 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 127 58 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 127 59 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 128 1 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 128 2 viability viability NN work_zbi2knhp65ho5n7vbsuthmd7gi 128 3 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 128 4 analyzed analyze VBN work_zbi2knhp65ho5n7vbsuthmd7gi 128 5 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 128 6 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 128 7 cytometry cytometry NN work_zbi2knhp65ho5n7vbsuthmd7gi 128 8 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 129 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 129 2 bar bar NN work_zbi2knhp65ho5n7vbsuthmd7gi 129 3 graph graph NN work_zbi2knhp65ho5n7vbsuthmd7gi 129 4 summarizes summarize VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 129 5 data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 129 6 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 129 7 three three CD work_zbi2knhp65ho5n7vbsuthmd7gi 129 8 repeats repeat NNS work_zbi2knhp65ho5n7vbsuthmd7gi 129 9 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 129 10 n n CC work_zbi2knhp65ho5n7vbsuthmd7gi 129 11 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 129 12 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 129 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 129 14 mean mean NNP work_zbi2knhp65ho5n7vbsuthmd7gi 129 15 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 129 16 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 129 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 129 18 D. D. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 129 19 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 129 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 130 1 Data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 130 2 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 130 3 analyzed analyze VBN work_zbi2knhp65ho5n7vbsuthmd7gi 130 4 employing employ VBG work_zbi2knhp65ho5n7vbsuthmd7gi 130 5 one one CD work_zbi2knhp65ho5n7vbsuthmd7gi 130 6 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 130 7 way way NN work_zbi2knhp65ho5n7vbsuthmd7gi 130 8 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 130 9 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 130 10 variance variance NN work_zbi2knhp65ho5n7vbsuthmd7gi 130 11 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 130 12 aNOVa aNOVa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 130 13 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 130 14 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 130 15 Tukey Tukey NNP work_zbi2knhp65ho5n7vbsuthmd7gi 130 16 ’s ’s POS work_zbi2knhp65ho5n7vbsuthmd7gi 130 17 post post FW work_zbi2knhp65ho5n7vbsuthmd7gi 130 18 hoc hoc FW work_zbi2knhp65ho5n7vbsuthmd7gi 130 19 test test NN work_zbi2knhp65ho5n7vbsuthmd7gi 130 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 131 1 Means mean NNS work_zbi2knhp65ho5n7vbsuthmd7gi 131 2 without without IN work_zbi2knhp65ho5n7vbsuthmd7gi 131 3 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 131 4 common common JJ work_zbi2knhp65ho5n7vbsuthmd7gi 131 5 letter letter NN work_zbi2knhp65ho5n7vbsuthmd7gi 131 6 differ differ VBP work_zbi2knhp65ho5n7vbsuthmd7gi 131 7 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 131 8 each each DT work_zbi2knhp65ho5n7vbsuthmd7gi 131 9 other other JJ work_zbi2knhp65ho5n7vbsuthmd7gi 131 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 131 11 P p NN work_zbi2knhp65ho5n7vbsuthmd7gi 131 12 < < XX work_zbi2knhp65ho5n7vbsuthmd7gi 131 13 0.05 0.05 CD work_zbi2knhp65ho5n7vbsuthmd7gi 131 14 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 131 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 132 1 © © LS work_zbi2knhp65ho5n7vbsuthmd7gi 132 2 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 132 3 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 132 4 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 132 5 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 132 6 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 132 7 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 132 8 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 132 9 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 132 10 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 132 11 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 132 12 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 132 13 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 132 14 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 132 15 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 132 16 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 132 17 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 132 18 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 132 19 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 132 20 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 132 21 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 132 22 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 132 23 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 132 24 www.landesbioscience.com www.landesbioscience.com NNP work_zbi2knhp65ho5n7vbsuthmd7gi 132 25 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 132 26 2093 2093 CD work_zbi2knhp65ho5n7vbsuthmd7gi 132 27 Figure Figure NNP work_zbi2knhp65ho5n7vbsuthmd7gi 132 28     _SP work_zbi2knhp65ho5n7vbsuthmd7gi 132 29 5 5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 132 30 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 133 1 Gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 133 2 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 133 3 array array NN work_zbi2knhp65ho5n7vbsuthmd7gi 133 4 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 133 5 performed perform VBN work_zbi2knhp65ho5n7vbsuthmd7gi 133 6 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 133 7 a375 a375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 133 8 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 133 9 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 133 10 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 133 11 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 133 12 amodiaquine amodiaquine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 133 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 134 1 Gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 134 2 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 134 3 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 134 4 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 134 5 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 134 6 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 134 7 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 134 8 25 25 CD work_zbi2knhp65ho5n7vbsuthmd7gi 134 9 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 134 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 134 11 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 134 12 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 134 13 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 134 14 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 134 15 analyzed analyze VBN work_zbi2knhp65ho5n7vbsuthmd7gi 134 16 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 134 17 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 134 18 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 134 19 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 134 20 RT2ProfilerTM RT2ProfilerTM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 134 21 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 134 22 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 134 23 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 134 24 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 134 25 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 134 26 Toxicity Toxicity NNP work_zbi2knhp65ho5n7vbsuthmd7gi 134 27 RT2ProfilerTM RT2ProfilerTM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 134 28 PcR PcR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 134 29 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 134 30 arrays arrays NNP work_zbi2knhp65ho5n7vbsuthmd7gi 134 31 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 135 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 135 2 A a NN work_zbi2knhp65ho5n7vbsuthmd7gi 135 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 135 4 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 135 5 scatter scatter NN work_zbi2knhp65ho5n7vbsuthmd7gi 135 6 blot blot NN work_zbi2knhp65ho5n7vbsuthmd7gi 135 7 depicts depict VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 135 8 differential differential NN work_zbi2knhp65ho5n7vbsuthmd7gi 135 9 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 135 10 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 135 11 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 135 12 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 135 13 vs. vs. IN work_zbi2knhp65ho5n7vbsuthmd7gi 135 14 untreated untreated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 135 15 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 135 16 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 135 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 136 1 Upper upper JJ work_zbi2knhp65ho5n7vbsuthmd7gi 136 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 136 3 lower low JJR work_zbi2knhp65ho5n7vbsuthmd7gi 136 4 lines line NNS work_zbi2knhp65ho5n7vbsuthmd7gi 136 5 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 136 6 cut cut VBN work_zbi2knhp65ho5n7vbsuthmd7gi 136 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 136 8 off off RP work_zbi2knhp65ho5n7vbsuthmd7gi 136 9 indicating indicate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 136 10 2-fold 2-fold CD work_zbi2knhp65ho5n7vbsuthmd7gi 136 11 up- up- CD work_zbi2knhp65ho5n7vbsuthmd7gi 136 12 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 136 13 downregulated downregulated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 136 14 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 136 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 136 16 respectively respectively RB work_zbi2knhp65ho5n7vbsuthmd7gi 136 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 137 1 arrays arrays NNP work_zbi2knhp65ho5n7vbsuthmd7gi 137 2 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 137 3 performed perform VBN work_zbi2knhp65ho5n7vbsuthmd7gi 137 4 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 137 5 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 137 6 independent independent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 137 7 repeats repeat NNS work_zbi2knhp65ho5n7vbsuthmd7gi 137 8 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 137 9 analyzed analyze VBD work_zbi2knhp65ho5n7vbsuthmd7gi 137 10 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 137 11 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 137 12 two two CD work_zbi2knhp65ho5n7vbsuthmd7gi 137 13 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 137 14 sided sided JJ work_zbi2knhp65ho5n7vbsuthmd7gi 137 15 student student NN work_zbi2knhp65ho5n7vbsuthmd7gi 137 16 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 137 17 test test NN work_zbi2knhp65ho5n7vbsuthmd7gi 137 18 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 138 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 138 2 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 138 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 138 4 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 138 5 table table NN work_zbi2knhp65ho5n7vbsuthmd7gi 138 6 summarizes summarize VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 138 7 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 138 8 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 138 9 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 138 10 at at RB work_zbi2knhp65ho5n7vbsuthmd7gi 138 11 least least JJS work_zbi2knhp65ho5n7vbsuthmd7gi 138 12 2-fold 2-fold CD work_zbi2knhp65ho5n7vbsuthmd7gi 138 13 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 138 14 P p NN work_zbi2knhp65ho5n7vbsuthmd7gi 138 15 < < XX work_zbi2knhp65ho5n7vbsuthmd7gi 138 16 0.05 0.05 CD work_zbi2knhp65ho5n7vbsuthmd7gi 138 17 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 138 18 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 139 1 © © LS work_zbi2knhp65ho5n7vbsuthmd7gi 139 2 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 139 3 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 139 4 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 5 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 139 6 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 7 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 8 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 9 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 139 10 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 139 11 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 12 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 139 13 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 14 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 15 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 16 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 139 17 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 18 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 19 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 139 20 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 139 21 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 139 22 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 139 23 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 24 2094 2094 CD work_zbi2knhp65ho5n7vbsuthmd7gi 139 25 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 26 Volume Volume NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 27 9 9 CD work_zbi2knhp65ho5n7vbsuthmd7gi 139 28 issue issue NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 29 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 139 30 15 15 CD work_zbi2knhp65ho5n7vbsuthmd7gi 139 31 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 139 32 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 139 33 member member NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 34 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 139 35 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 139 36 transforming transforming NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 37 growth growth NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 38 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 39 β β NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 40 superfamily superfamily RB work_zbi2knhp65ho5n7vbsuthmd7gi 139 41 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 139 42 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 139 43 observed.65 observed.65 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 44 Finally finally RB work_zbi2knhp65ho5n7vbsuthmd7gi 139 45 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 139 46 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 47 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 48 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 139 49 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 139 50 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 51 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 139 52 affecting affect VBG work_zbi2knhp65ho5n7vbsuthmd7gi 139 53 genes gene NNS work_zbi2knhp65ho5n7vbsuthmd7gi 139 54 involved involve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 139 55 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 139 56 inflammatory inflammatory JJ work_zbi2knhp65ho5n7vbsuthmd7gi 139 57 signaling signaling NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 58 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 139 59 IL6 il6 NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 60 encoding encode VBG work_zbi2knhp65ho5n7vbsuthmd7gi 139 61 interleukin interleukin VB work_zbi2knhp65ho5n7vbsuthmd7gi 139 62 6 6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 139 63 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 139 64 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 139 65 interferon interferon NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 66 β β NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 67 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 139 68 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 139 69 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 139 70 CSF2 CSF2 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 71 encoding encode VBG work_zbi2knhp65ho5n7vbsuthmd7gi 139 72 colony colony NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 73 stimulating stimulate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 139 74 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 75 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 139 76 granulocyte granulocyte NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 77 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 139 78 macrophage macrophage NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 79 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 139 80 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 139 81 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 139 82 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 139 83 regulation regulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 84 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 139 85 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 86 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 139 87 related relate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 139 88 genes gene NNS work_zbi2knhp65ho5n7vbsuthmd7gi 139 89 ATG9A ATG9A '' work_zbi2knhp65ho5n7vbsuthmd7gi 139 90 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 139 91 ATG9B atg9b CD work_zbi2knhp65ho5n7vbsuthmd7gi 139 92 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 139 93 ATG4D atg4d NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 94 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 139 95 GABARAPL1 gabarapl1 NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 96 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 139 97 BNIP3 BNIP3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 139 98 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 139 99 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 139 100 but but CC work_zbi2knhp65ho5n7vbsuthmd7gi 139 101 none none NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 102 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 139 103 these these DT work_zbi2knhp65ho5n7vbsuthmd7gi 139 104 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 139 105 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 139 106 substan- substan- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 139 107 tiated tiate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 139 108 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 139 109 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 139 110 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 111 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 139 112 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 140 1 Antiproliferative antiproliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 140 2 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 140 4 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 140 5 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 140 6 associated associate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 140 7 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 140 8 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 140 9 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 10 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 11 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 12 arrest arrest NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 13 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 140 14 modulation modulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 15 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 140 16 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 140 17 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 140 18 /S /s NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 19 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 20 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 21 regulators regulator NNS work_zbi2knhp65ho5n7vbsuthmd7gi 140 22 Flow flow VBP work_zbi2knhp65ho5n7vbsuthmd7gi 140 23 cytometric cytometric NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 24 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 25 revealed reveal VBD work_zbi2knhp65ho5n7vbsuthmd7gi 140 26 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 140 27 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 140 28 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 29 imposed impose VBD work_zbi2knhp65ho5n7vbsuthmd7gi 140 30 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 140 31 alterations alteration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 140 32 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 140 33 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 34 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 35 distribution distribution NN work_zbi2knhp65ho5n7vbsuthmd7gi 140 36 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 141 1 Specifically specifically RB work_zbi2knhp65ho5n7vbsuthmd7gi 141 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 141 3 continuous continuous JJ work_zbi2knhp65ho5n7vbsuthmd7gi 141 4 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 141 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 141 6 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 141 7 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 141 8 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 141 9 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 141 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 141 11 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 141 12 μM μm CD work_zbi2knhp65ho5n7vbsuthmd7gi 141 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 141 14 48 48 CD work_zbi2knhp65ho5n7vbsuthmd7gi 141 15 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 141 16 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 141 17 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 141 18 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 141 19 statistically statistically RB work_zbi2knhp65ho5n7vbsuthmd7gi 141 20 significant significant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 141 21 increase increase NN work_zbi2knhp65ho5n7vbsuthmd7gi 141 22 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 141 23 S s NN work_zbi2knhp65ho5n7vbsuthmd7gi 141 24 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 141 25 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 141 26 fraction fraction NN work_zbi2knhp65ho5n7vbsuthmd7gi 141 27 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 141 28 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 141 29 accompanied accompany VBN work_zbi2knhp65ho5n7vbsuthmd7gi 141 30 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 141 31 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 141 32 decrease decrease NN work_zbi2knhp65ho5n7vbsuthmd7gi 141 33 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 141 34 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 141 35 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 141 36 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 141 37 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 141 38 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 141 39 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 141 40 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 141 41 /M /M . work_zbi2knhp65ho5n7vbsuthmd7gi 141 42 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 141 43 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 141 44 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 141 45 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 142 1 6D 6d NN work_zbi2knhp65ho5n7vbsuthmd7gi 142 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 142 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 143 1 Specifically specifically RB work_zbi2knhp65ho5n7vbsuthmd7gi 143 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 143 3 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 143 4 fraction fraction NN work_zbi2knhp65ho5n7vbsuthmd7gi 143 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 143 6 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 143 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 143 8 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 143 9 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 143 10 increased increase VBD work_zbi2knhp65ho5n7vbsuthmd7gi 143 11 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 143 12 approximately approximately RB work_zbi2knhp65ho5n7vbsuthmd7gi 143 13 35 35 CD work_zbi2knhp65ho5n7vbsuthmd7gi 143 14 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 143 15 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 143 16 60 60 CD work_zbi2knhp65ho5n7vbsuthmd7gi 143 17 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 143 18 upon upon IN work_zbi2knhp65ho5n7vbsuthmd7gi 143 19 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 143 20 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 143 21 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 143 22 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 143 23 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 143 24 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 143 25 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 143 26 48 48 CD work_zbi2knhp65ho5n7vbsuthmd7gi 143 27 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 143 28 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 143 29 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 143 30 accompanied accompany VBN work_zbi2knhp65ho5n7vbsuthmd7gi 143 31 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 143 32 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 143 33 depletion depletion NN work_zbi2knhp65ho5n7vbsuthmd7gi 143 34 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 143 35 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 143 36 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 143 37 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 143 38 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 143 39 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 143 40 G g NN work_zbi2knhp65ho5n7vbsuthmd7gi 143 41 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 143 42 /M. /M. . work_zbi2knhp65ho5n7vbsuthmd7gi 144 1 Further further JJ work_zbi2knhp65ho5n7vbsuthmd7gi 144 2 experiments experiment NNS work_zbi2knhp65ho5n7vbsuthmd7gi 144 3 employing employ VBG work_zbi2knhp65ho5n7vbsuthmd7gi 144 4 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 144 5 panel panel NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 144 7 cul- cul- RB work_zbi2knhp65ho5n7vbsuthmd7gi 144 8 tured ture VBD work_zbi2knhp65ho5n7vbsuthmd7gi 144 9 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 144 10 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 144 11 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 12 lines line NNS work_zbi2knhp65ho5n7vbsuthmd7gi 144 13 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 144 14 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 144 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 144 16 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 144 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 144 18 LOX LOX NNP work_zbi2knhp65ho5n7vbsuthmd7gi 144 19 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 144 20 con- con- NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 21 firmed firm VBD work_zbi2knhp65ho5n7vbsuthmd7gi 144 22 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 144 23 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 144 24 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 144 25 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 144 26 antiproliferative antiproliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 144 27 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 28 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 144 29 Figure figure NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 30   _SP work_zbi2knhp65ho5n7vbsuthmd7gi 144 31 6 6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 144 32 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 144 33 amodiaquine amodiaquine JJ work_zbi2knhp65ho5n7vbsuthmd7gi 144 34 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 35 modulates modulate VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 144 36 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 37 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 38 regulators regulator NNS work_zbi2knhp65ho5n7vbsuthmd7gi 144 39 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 144 40 cDKN1a cDKN1a NNP work_zbi2knhp65ho5n7vbsuthmd7gi 144 41 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 144 42 RB1 RB1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 144 43 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 144 44 ser780 ser780 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 144 45 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 144 46 ser807/811 ser807/811 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 144 47 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 144 48 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 144 49 ccND1 ccND1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 144 50 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 144 51 e2F1 e2f1 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 144 52 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 144 53 causing cause VBG work_zbi2knhp65ho5n7vbsuthmd7gi 144 54 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 55 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 144 56 proliferation proliferation NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 57 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 144 58 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 144 59 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 60 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 61 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 62 arrest arrest NN work_zbi2knhp65ho5n7vbsuthmd7gi 144 63 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 145 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 145 2 A a DT work_zbi2knhp65ho5n7vbsuthmd7gi 145 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 145 4 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 145 5 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 145 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 145 7 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 145 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 145 9 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 145 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 145 11 ≤ ≤ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 145 12 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 145 13 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 145 14 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 145 15 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 145 16 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 145 17 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 145 18 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 145 19 changes change VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 145 20 affecting affect VBG work_zbi2knhp65ho5n7vbsuthmd7gi 145 21 heat heat NN work_zbi2knhp65ho5n7vbsuthmd7gi 145 22 shock shock NN work_zbi2knhp65ho5n7vbsuthmd7gi 145 23 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 145 24 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 145 25 major major JJ work_zbi2knhp65ho5n7vbsuthmd7gi 145 26 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 145 27 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 145 28 regulators regulator NNS work_zbi2knhp65ho5n7vbsuthmd7gi 145 29 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 145 30 a375 a375 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 145 31 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 145 32 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 145 33 loading loading NN work_zbi2knhp65ho5n7vbsuthmd7gi 145 34 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 145 35 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 145 36 acTB acTB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 145 37 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 145 38 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 146 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 146 2 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 146 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 146 4 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 146 5 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 146 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 146 7 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 146 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 146 9 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 146 10 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 146 11 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 146 12 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 146 13 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 146 14 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 146 15 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 146 16 treated treat VBN work_zbi2knhp65ho5n7vbsuthmd7gi 146 17 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 146 18 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 146 19 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 146 20 A a NN work_zbi2knhp65ho5n7vbsuthmd7gi 146 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 146 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 147 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 147 2 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 147 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 147 4 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 147 5 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 147 6 HSPA1A hspa1a UH work_zbi2knhp65ho5n7vbsuthmd7gi 147 7 mRNa mrna NN work_zbi2knhp65ho5n7vbsuthmd7gi 147 8 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 147 9 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 147 10 a375 a375 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 147 11 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 147 12 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 147 13 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 147 14 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 147 15 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 147 16 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 147 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 147 18 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 147 19 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 147 20 40 40 CD work_zbi2knhp65ho5n7vbsuthmd7gi 147 21 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 147 22 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 147 23 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 147 24 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 147 25 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 147 26 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 147 27 determined determine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 147 28 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 147 29 real real JJ work_zbi2knhp65ho5n7vbsuthmd7gi 147 30 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 147 31 RT RT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 147 32 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 147 33 PcR PcR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 147 34 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 147 35 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 147 36 mean mean NNP work_zbi2knhp65ho5n7vbsuthmd7gi 147 37 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 147 38 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 147 39 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 147 40 D. D. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 147 41 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 147 42 n n NNP work_zbi2knhp65ho5n7vbsuthmd7gi 147 43 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 147 44 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 147 45 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 147 46 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 148 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 148 2 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 148 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 148 4 Representative Representative NNP work_zbi2knhp65ho5n7vbsuthmd7gi 148 5 histogram histogram NNP work_zbi2knhp65ho5n7vbsuthmd7gi 148 6 depicting depict VBG work_zbi2knhp65ho5n7vbsuthmd7gi 148 7 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 148 8 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 148 9 distribution distribution NN work_zbi2knhp65ho5n7vbsuthmd7gi 148 10 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 148 11 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 148 12 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 148 13 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 148 14 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 148 15 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 148 16 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 148 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 148 18 ≤ ≤ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 148 19 48 48 CD work_zbi2knhp65ho5n7vbsuthmd7gi 148 20 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 148 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 148 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 149 1 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 149 2 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 149 3 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 149 4 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 149 5 indicated indicate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 149 6 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 149 7 periods period NNS work_zbi2knhp65ho5n7vbsuthmd7gi 149 8 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 149 9 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 149 10 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 149 11 stained stain VBN work_zbi2knhp65ho5n7vbsuthmd7gi 149 12 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 149 13 Pi Pi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 149 14 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 149 15 analyzed analyze VBN work_zbi2knhp65ho5n7vbsuthmd7gi 149 16 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 149 17 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 149 18 cytometry cytometry NN work_zbi2knhp65ho5n7vbsuthmd7gi 149 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 150 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 150 2 data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 150 3 indicate indicate VBP work_zbi2knhp65ho5n7vbsuthmd7gi 150 4 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 150 5 percentage percentage NN work_zbi2knhp65ho5n7vbsuthmd7gi 150 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 150 7 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 150 8 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 150 9 each each DT work_zbi2knhp65ho5n7vbsuthmd7gi 150 10 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 150 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 150 12 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 150 13 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 150 14 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 150 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 151 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 151 2 table table NN work_zbi2knhp65ho5n7vbsuthmd7gi 151 3 summarizes summarize VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 151 4 results result NNS work_zbi2knhp65ho5n7vbsuthmd7gi 151 5 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 151 6 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 151 7 independent independent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 151 8 repeat repeat NN work_zbi2knhp65ho5n7vbsuthmd7gi 151 9 experiments experiment NNS work_zbi2knhp65ho5n7vbsuthmd7gi 151 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 151 11 mean mean VB work_zbi2knhp65ho5n7vbsuthmd7gi 151 12 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 151 13 sD sD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 151 14 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 151 15 n n NN work_zbi2knhp65ho5n7vbsuthmd7gi 151 16 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 151 17 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 151 18 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 151 19 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 151 20 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 151 21 P p NN work_zbi2knhp65ho5n7vbsuthmd7gi 151 22 < < XX work_zbi2knhp65ho5n7vbsuthmd7gi 151 23 0.05 0.05 XX work_zbi2knhp65ho5n7vbsuthmd7gi 151 24 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 151 25 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 151 26 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 151 27 P p NN work_zbi2knhp65ho5n7vbsuthmd7gi 151 28 < < XX work_zbi2knhp65ho5n7vbsuthmd7gi 151 29 0.01 0.01 XX work_zbi2knhp65ho5n7vbsuthmd7gi 151 30 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 151 31 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 151 32 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 151 33 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 151 34 P p NN work_zbi2knhp65ho5n7vbsuthmd7gi 151 35 < < XX work_zbi2knhp65ho5n7vbsuthmd7gi 151 36 0.001 0.001 CD work_zbi2knhp65ho5n7vbsuthmd7gi 151 37 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 151 38 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 152 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 152 2 E e NN work_zbi2knhp65ho5n7vbsuthmd7gi 152 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 152 4 Dose dose NN work_zbi2knhp65ho5n7vbsuthmd7gi 152 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 152 6 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 152 7 relationship relationship NN work_zbi2knhp65ho5n7vbsuthmd7gi 152 8 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 152 9 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 152 10 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 152 11 cQ cQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 152 12 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 152 13 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 152 14 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 152 15 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 152 16 proliferation proliferation NN work_zbi2knhp65ho5n7vbsuthmd7gi 152 17 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 152 18 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 152 19 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 152 20 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 152 21 lines line NNS work_zbi2knhp65ho5n7vbsuthmd7gi 152 22 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 152 23 a375 a375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 152 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 152 25 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 152 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 152 27 LOX LOX NNP work_zbi2knhp65ho5n7vbsuthmd7gi 152 28 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 152 29 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 153 1 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 153 2 72 72 CD work_zbi2knhp65ho5n7vbsuthmd7gi 153 3 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 153 4 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 153 5 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 153 6 increasing increase VBG work_zbi2knhp65ho5n7vbsuthmd7gi 153 7 concentrations concentration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 153 8 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 153 9 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 153 10 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 153 11 cQ cQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 153 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 153 13 number number NN work_zbi2knhp65ho5n7vbsuthmd7gi 153 14 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 153 15 adherent adherent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 153 16 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 153 17 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 153 18 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 153 19 dish dish NN work_zbi2knhp65ho5n7vbsuthmd7gi 153 20 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 153 21 determined determine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 153 22 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 153 23 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 153 24 counting counting NN work_zbi2knhp65ho5n7vbsuthmd7gi 153 25 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 153 26 expressed express VBD work_zbi2knhp65ho5n7vbsuthmd7gi 153 27 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 153 28 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 153 29 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 153 30 untreated untreated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 153 31 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 153 32 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 153 33 means mean VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 153 34 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 153 35 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 153 36 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 153 37 D. D. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 1 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 154 2 n n LS work_zbi2knhp65ho5n7vbsuthmd7gi 154 3 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 154 4 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 5 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 154 6 © © CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 7 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 8 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 9 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 154 10 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 154 11 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 154 12 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 13 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 154 14 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 154 15 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 154 16 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 17 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 154 18 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 19 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 20 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 154 21 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 154 22 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 154 23 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 154 24 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 154 25 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 154 26 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 154 27 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 154 28 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 29 www.landesbioscience.com www.landesbioscience.com NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 30 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 31 2095 2095 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 32 submicromolar submicromolar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 154 33 concentrations concentration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 154 34 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 154 35 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 36 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 154 37 IC IC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 38 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 39 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 154 40 0.32 0.32 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 41 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 42 0.12 0.12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 43 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 44 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 154 45 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 46 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 154 47 IC IC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 48 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 49 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 154 50 0.71 0.71 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 51 ± ± CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 52 0.16 0.16 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 53 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 54 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 154 55 LOX LOX NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 56 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 154 57 IC IC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 58 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 59 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 154 60 2.60 2.60 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 61 ± ± CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 62 0.74 0.74 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 63 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 64 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 154 65 mean mean NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 66 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 67 SD sd NN work_zbi2knhp65ho5n7vbsuthmd7gi 154 68 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 154 69 n n NN work_zbi2knhp65ho5n7vbsuthmd7gi 154 70 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 154 71 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 154 72 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 154 73 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 154 74 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 155 1 6E 6E NNP work_zbi2knhp65ho5n7vbsuthmd7gi 155 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 155 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 156 1 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 156 2 order order NN work_zbi2knhp65ho5n7vbsuthmd7gi 156 3 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 156 4 substantiate substantiate VB work_zbi2knhp65ho5n7vbsuthmd7gi 156 5 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 156 6 molecular molecular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 156 7 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 156 8 underlying underlie VBG work_zbi2knhp65ho5n7vbsuthmd7gi 156 9 antiproliferative antiproliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 156 10 effects effect NNS work_zbi2knhp65ho5n7vbsuthmd7gi 156 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 156 12 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 156 13 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 156 14 exam- exam- VBD work_zbi2knhp65ho5n7vbsuthmd7gi 156 15 ined ined JJ work_zbi2knhp65ho5n7vbsuthmd7gi 156 16 modulation modulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 156 17 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 156 18 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 156 19 regulators regulator NNS work_zbi2knhp65ho5n7vbsuthmd7gi 156 20 determin- determin- VBP work_zbi2knhp65ho5n7vbsuthmd7gi 156 21 ing ing NNP work_zbi2knhp65ho5n7vbsuthmd7gi 156 22 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 156 23 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 156 24 /S /s NN work_zbi2knhp65ho5n7vbsuthmd7gi 156 25 transition transition NN work_zbi2knhp65ho5n7vbsuthmd7gi 156 26 focusing focus VBG work_zbi2knhp65ho5n7vbsuthmd7gi 156 27 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 156 28 those those DT work_zbi2knhp65ho5n7vbsuthmd7gi 156 29 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 156 30 displayed display VBD work_zbi2knhp65ho5n7vbsuthmd7gi 156 31 major major JJ work_zbi2knhp65ho5n7vbsuthmd7gi 156 32 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 156 33 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 156 34 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 156 35 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 156 36 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 156 37 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 156 38 detected detect VBN work_zbi2knhp65ho5n7vbsuthmd7gi 156 39 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 156 40 array array NN work_zbi2knhp65ho5n7vbsuthmd7gi 156 41 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 156 42 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 156 43 TP53 TP53 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 156 44 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 156 45 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 156 46 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 156 47 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 156 48 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 156 49 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 156 50 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 156 51 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 157 1 6A 6a NN work_zbi2knhp65ho5n7vbsuthmd7gi 157 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 157 3 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 157 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 157 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 158 1 We -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 158 2 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 158 3 examined examine VBD work_zbi2knhp65ho5n7vbsuthmd7gi 158 4 CCND1 CCND1 '' work_zbi2knhp65ho5n7vbsuthmd7gi 158 5 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 158 6 cyclin cyclin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 158 7 D1 D1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 158 8 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 158 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 158 10 phosphorylation phosphorylation NN work_zbi2knhp65ho5n7vbsuthmd7gi 158 11 status status NN work_zbi2knhp65ho5n7vbsuthmd7gi 158 12 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 158 13 RB1 RB1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 158 14 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 158 15 retinoblastoma retinoblastoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 158 16 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 158 17 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 158 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 158 19 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 158 20 MYC MYC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 158 21 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 159 1 Immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 2 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 3 revealed reveal VBD work_zbi2knhp65ho5n7vbsuthmd7gi 159 4 pronounced pronounce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 159 5 upregu- upregu- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 159 6 lation lation NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 159 8 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 159 9 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 10 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 159 11 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 159 12 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 159 13 potent potent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 159 14 cyclin cyclin JJ work_zbi2knhp65ho5n7vbsuthmd7gi 159 15 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 159 16 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 159 17 kinase kinase NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 18 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 19 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 159 20 directly directly RB work_zbi2knhp65ho5n7vbsuthmd7gi 159 21 inhibits inhibit VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 159 22 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 159 23 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 24 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 159 25 CCNE CCNE NNP work_zbi2knhp65ho5n7vbsuthmd7gi 159 26 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 159 27 cyclin cyclin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 159 28 E)-CDK2 E)-CDK2 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 159 29 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 159 30 CCND CCND NNP work_zbi2knhp65ho5n7vbsuthmd7gi 159 31 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 159 32 CDK4/6 CDK4/6 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 159 33 complexes complex NNS work_zbi2knhp65ho5n7vbsuthmd7gi 159 34 involved involve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 159 35 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 159 36 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 159 37 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 159 38 /S /s NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 39 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 40 transition transition NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 41 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 159 42 progression.60,66 progression.60,66 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 159 43 Consistent Consistent NNP work_zbi2knhp65ho5n7vbsuthmd7gi 159 44 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 159 45 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 159 46 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 159 47 dose dose NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 48 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 159 49 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 159 50 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 51 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 159 52 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 159 53 mRNA mrna NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 54 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 159 55 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 159 56 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 57 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 159 58 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 159 59 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 159 60 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 160 1 5 5 LS work_zbi2knhp65ho5n7vbsuthmd7gi 160 2 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 160 3 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 160 4 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 161 1 6A 6A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 161 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 161 3 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 161 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 161 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 161 6 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 161 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 161 8 TP53 TP53 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 161 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 161 10 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 161 11 transcriptional transcriptional JJ work_zbi2knhp65ho5n7vbsuthmd7gi 161 12 regulator regulator NN work_zbi2knhp65ho5n7vbsuthmd7gi 161 13 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 161 14 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 161 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 161 16 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 161 17 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 161 18 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 161 19 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 161 20 transcriptional transcriptional JJ work_zbi2knhp65ho5n7vbsuthmd7gi 161 21 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 161 22 TP53 tp53 IN work_zbi2knhp65ho5n7vbsuthmd7gi 161 23 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 161 24 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 161 25 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 162 1 5B 5b JJ work_zbi2knhp65ho5n7vbsuthmd7gi 162 2 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 162 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 162 4 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 162 5 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 162 6 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 162 7 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 162 8 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 162 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 163 1 6A 6a NN work_zbi2knhp65ho5n7vbsuthmd7gi 163 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 163 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 164 1 Moreover moreover RB work_zbi2knhp65ho5n7vbsuthmd7gi 164 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 164 3 moderate moderate JJ work_zbi2knhp65ho5n7vbsuthmd7gi 164 4 suppression suppression NN work_zbi2knhp65ho5n7vbsuthmd7gi 164 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 164 6 CCND1 ccnd1 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 164 7 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 164 8 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 164 9 occurred occur VBD work_zbi2knhp65ho5n7vbsuthmd7gi 164 10 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 164 11 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 164 12 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 164 13 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 164 14 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 164 15 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 164 16 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 164 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 165 1 6A 6a NN work_zbi2knhp65ho5n7vbsuthmd7gi 165 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 165 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 166 1 Next next RB work_zbi2knhp65ho5n7vbsuthmd7gi 166 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 166 3 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 166 4 focused focus VBD work_zbi2knhp65ho5n7vbsuthmd7gi 166 5 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 166 6 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 166 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 166 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 166 9 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 166 10 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 166 11 displayed display VBD work_zbi2knhp65ho5n7vbsuthmd7gi 166 12 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 166 13 most most RBS work_zbi2knhp65ho5n7vbsuthmd7gi 166 14 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 166 15 downregulation downregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 166 16 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 166 17 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 166 18 transcriptional transcriptional JJ work_zbi2knhp65ho5n7vbsuthmd7gi 166 19 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 166 20 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 166 21 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 166 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 167 1 5A 5a RB work_zbi2knhp65ho5n7vbsuthmd7gi 167 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 167 3 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 167 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 167 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 168 1 Remarkably remarkably RB work_zbi2knhp65ho5n7vbsuthmd7gi 168 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 168 3 AQ aq NN work_zbi2knhp65ho5n7vbsuthmd7gi 168 4 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 168 5 suppression suppression NN work_zbi2knhp65ho5n7vbsuthmd7gi 168 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 168 7 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 168 8 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 168 9 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 168 10 con- con- NN work_zbi2knhp65ho5n7vbsuthmd7gi 168 11 firmed firm VBN work_zbi2knhp65ho5n7vbsuthmd7gi 168 12 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 168 13 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 168 14 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 168 15 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 168 16 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 168 17 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 168 18 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 169 1 6A 6a NN work_zbi2knhp65ho5n7vbsuthmd7gi 169 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 169 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 170 1 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 170 2 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 170 3 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 170 4 transcription transcription NN work_zbi2knhp65ho5n7vbsuthmd7gi 170 5 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 170 6 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 170 7 master master NN work_zbi2knhp65ho5n7vbsuthmd7gi 170 8 regulator regulator NN work_zbi2knhp65ho5n7vbsuthmd7gi 170 9 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 170 10 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 170 11 proliferation proliferation NN work_zbi2knhp65ho5n7vbsuthmd7gi 170 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 170 13 expressed express VBD work_zbi2knhp65ho5n7vbsuthmd7gi 170 14 mainly mainly RB work_zbi2knhp65ho5n7vbsuthmd7gi 170 15 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 170 16 late late JJ work_zbi2knhp65ho5n7vbsuthmd7gi 170 17 G g NN work_zbi2knhp65ho5n7vbsuthmd7gi 170 18 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 170 19 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 170 20 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 170 21 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 170 22 /S /s NN work_zbi2knhp65ho5n7vbsuthmd7gi 170 23 transition transition NN work_zbi2knhp65ho5n7vbsuthmd7gi 170 24 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 170 25 all all DT work_zbi2knhp65ho5n7vbsuthmd7gi 170 26 actively actively RB work_zbi2knhp65ho5n7vbsuthmd7gi 170 27 proliferating proliferate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 170 28 tissues.67 tissues.67 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 170 29 - - : work_zbi2knhp65ho5n7vbsuthmd7gi 170 30 69 69 CD work_zbi2knhp65ho5n7vbsuthmd7gi 170 31 We -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 170 32 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 170 33 examined examine VBD work_zbi2knhp65ho5n7vbsuthmd7gi 170 34 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 170 35 modulation modulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 170 36 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 170 37 RB1 RB1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 170 38 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 170 39 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 170 40 upstream upstream JJ work_zbi2knhp65ho5n7vbsuthmd7gi 170 41 regulator regulator NN work_zbi2knhp65ho5n7vbsuthmd7gi 170 42 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 170 43 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 170 44 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 170 45 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 171 1 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 171 2 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 3 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 171 4 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 171 5 reactivation reactivation NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 7 RB1 rb1 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 171 8 tumor tumor NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 9 suppressor suppressor NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 10 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 11 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 12 removal removal NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 13 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 14 inhibitory inhibitory NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 15 phos- phos- FW work_zbi2knhp65ho5n7vbsuthmd7gi 171 16 phorylations phorylation NNS work_zbi2knhp65ho5n7vbsuthmd7gi 171 17 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 18 Ser780 ser780 CD work_zbi2knhp65ho5n7vbsuthmd7gi 171 19 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 171 20 Ser807/811 ser807/811 CD work_zbi2knhp65ho5n7vbsuthmd7gi 171 21 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 171 22 interfere interfere VBP work_zbi2knhp65ho5n7vbsuthmd7gi 171 23 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 24 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 171 25 sequestration sequestration NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 171 27 established establish VBD work_zbi2knhp65ho5n7vbsuthmd7gi 171 28 sites site NNS work_zbi2knhp65ho5n7vbsuthmd7gi 171 29 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 30 posttranslational posttranslational JJ work_zbi2knhp65ho5n7vbsuthmd7gi 171 31 RB1 rb1 NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 32 regula- regula- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 171 33 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 34 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 35 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 171 36 G g NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 37 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 171 38 /S /S . work_zbi2knhp65ho5n7vbsuthmd7gi 171 39 checkpoint.70,71 checkpoint.70,71 NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 40 Since since IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 41 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 171 42 modulated modulate VBD work_zbi2knhp65ho5n7vbsuthmd7gi 171 43 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 171 44 number number NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 45 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 46 major major JJ work_zbi2knhp65ho5n7vbsuthmd7gi 171 47 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 48 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 49 regulators regulator NNS work_zbi2knhp65ho5n7vbsuthmd7gi 171 50 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 171 51 TP53 TP53 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 171 52 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 171 53 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 171 54 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 171 55 CCND1 CCND1 '' work_zbi2knhp65ho5n7vbsuthmd7gi 171 56 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 171 57 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 171 58 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 171 59 RB1 RB1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 171 60 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 171 61 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 171 62 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 171 63 involved involve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 171 64 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 65 functional functional JJ work_zbi2knhp65ho5n7vbsuthmd7gi 171 66 crosstalk crosstalk NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 67 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 68 MYC MYC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 171 69 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 171 70 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 171 71 examined examine VBD work_zbi2knhp65ho5n7vbsuthmd7gi 171 72 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 73 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 74 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 171 75 master master NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 76 regulator regulator NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 77 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 171 78 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 79 proliferation proliferation NN work_zbi2knhp65ho5n7vbsuthmd7gi 171 80 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 172 1 However however RB work_zbi2knhp65ho5n7vbsuthmd7gi 172 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 172 3 only only RB work_zbi2knhp65ho5n7vbsuthmd7gi 172 4 moderate moderate JJ work_zbi2knhp65ho5n7vbsuthmd7gi 172 5 downregulation downregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 172 6 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 172 7 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 172 8 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 172 9 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 172 10 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 172 11 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 172 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 172 13 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 172 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 173 1 6A 6a NN work_zbi2knhp65ho5n7vbsuthmd7gi 173 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 173 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 174 1 Importantly importantly RB work_zbi2knhp65ho5n7vbsuthmd7gi 174 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 174 3 key key JJ work_zbi2knhp65ho5n7vbsuthmd7gi 174 4 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 174 5 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 174 6 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 174 7 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 174 8 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 174 9 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 174 10 A375 a375 CD work_zbi2knhp65ho5n7vbsuthmd7gi 174 11 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 174 12 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 174 13 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 174 14 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 174 15 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 174 16 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 174 17 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 174 18 metastatic metastatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 174 19 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 174 20 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 174 21 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 174 22 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 174 23 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 174 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 174 25 where where WRB work_zbi2knhp65ho5n7vbsuthmd7gi 174 26 immu- immu- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 174 27 noblot noblot NNP work_zbi2knhp65ho5n7vbsuthmd7gi 174 28 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 174 29 confirmed confirm VBD work_zbi2knhp65ho5n7vbsuthmd7gi 174 30 downregulation downregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 174 31 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 174 32 heat heat NN work_zbi2knhp65ho5n7vbsuthmd7gi 174 33 shock shock NN work_zbi2knhp65ho5n7vbsuthmd7gi 174 34 pro- pro- NN work_zbi2knhp65ho5n7vbsuthmd7gi 174 35 teins tein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 174 36 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 174 37 HSPA1A hspa1a UH work_zbi2knhp65ho5n7vbsuthmd7gi 174 38 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 174 39 HSP90AA1 hsp90aa1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 174 40 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 174 41 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 174 42 pronounced pronounce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 174 43 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 174 44 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 174 45 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 174 46 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 174 47 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 174 48 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 174 49 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 174 50 antiproliferative antiproliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 174 51 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 174 52 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 174 53 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 174 54 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 174 55 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 174 56 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 175 1 6B 6b NN work_zbi2knhp65ho5n7vbsuthmd7gi 175 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 175 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 176 1 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 176 2 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 176 3 context context NN work_zbi2knhp65ho5n7vbsuthmd7gi 176 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 176 5 our -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 176 6 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 176 7 array array NN work_zbi2knhp65ho5n7vbsuthmd7gi 176 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 176 9 guided guide VBN work_zbi2knhp65ho5n7vbsuthmd7gi 176 10 exploration exploration NN work_zbi2knhp65ho5n7vbsuthmd7gi 176 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 176 12 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 176 13 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 176 14 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 176 15 antimelanoma antimelanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 176 16 effects effect NNS work_zbi2knhp65ho5n7vbsuthmd7gi 176 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 176 18 it -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 176 19 should should MD work_zbi2knhp65ho5n7vbsuthmd7gi 176 20 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 176 21 mentioned mention VBN work_zbi2knhp65ho5n7vbsuthmd7gi 176 22 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 176 23 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 176 24 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 176 25 did do VBD work_zbi2knhp65ho5n7vbsuthmd7gi 176 26 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 176 27 always always RB work_zbi2knhp65ho5n7vbsuthmd7gi 176 28 confirm confirm VB work_zbi2knhp65ho5n7vbsuthmd7gi 176 29 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 176 30 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 176 31 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 176 32 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 176 33 mRNA mrna JJ work_zbi2knhp65ho5n7vbsuthmd7gi 176 34 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 176 35 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 177 1 For for IN work_zbi2knhp65ho5n7vbsuthmd7gi 177 2 example example NN work_zbi2knhp65ho5n7vbsuthmd7gi 177 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 177 4 significant significant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 177 5 downregulation downregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 177 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 177 7 RPL13A rpl13a CD work_zbi2knhp65ho5n7vbsuthmd7gi 177 8 mRNA mRNA NNS work_zbi2knhp65ho5n7vbsuthmd7gi 177 9 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 177 10 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 177 11 3.5 3.5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 177 12 fold fold VBP work_zbi2knhp65ho5n7vbsuthmd7gi 177 13 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 177 14 encoding encode VBG work_zbi2knhp65ho5n7vbsuthmd7gi 177 15 60S 60s CD work_zbi2knhp65ho5n7vbsuthmd7gi 177 16 ribosomal ribosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 177 17 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 177 18 L13a L13a . work_zbi2knhp65ho5n7vbsuthmd7gi 177 19 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 177 20 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 177 21 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 178 1 5A 5a RB work_zbi2knhp65ho5n7vbsuthmd7gi 178 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 178 3 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 178 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 178 5 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 178 6 detected detect VBN work_zbi2knhp65ho5n7vbsuthmd7gi 178 7 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 178 8 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 178 9 array array NNP work_zbi2knhp65ho5n7vbsuthmd7gi 178 10 analy- analy- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 178 11 sis sis NNP work_zbi2knhp65ho5n7vbsuthmd7gi 178 12 but but CC work_zbi2knhp65ho5n7vbsuthmd7gi 178 13 could could MD work_zbi2knhp65ho5n7vbsuthmd7gi 178 14 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 178 15 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 178 16 substantiated substantiate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 178 17 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 178 18 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 178 19 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 178 20 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 178 21 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 178 22 RPL13A rpl13a XX work_zbi2knhp65ho5n7vbsuthmd7gi 178 23 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 178 24 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 178 25 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 179 1 6A 6a NN work_zbi2knhp65ho5n7vbsuthmd7gi 179 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 179 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 180 1 Therefore therefore RB work_zbi2knhp65ho5n7vbsuthmd7gi 180 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 180 3 other other JJ work_zbi2knhp65ho5n7vbsuthmd7gi 180 4 significant significant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 180 5 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 180 6 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 180 7 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 180 8 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 180 9 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 180 10 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 180 11 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 180 12 mRNA mrna JJ work_zbi2knhp65ho5n7vbsuthmd7gi 180 13 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 180 14 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 180 15 summarized summarize VBN work_zbi2knhp65ho5n7vbsuthmd7gi 180 16 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 180 17 Figure Figure NNP work_zbi2knhp65ho5n7vbsuthmd7gi 180 18 5B 5b NN work_zbi2knhp65ho5n7vbsuthmd7gi 180 19 await await VBP work_zbi2knhp65ho5n7vbsuthmd7gi 180 20 further further JJ work_zbi2knhp65ho5n7vbsuthmd7gi 180 21 validation validation NN work_zbi2knhp65ho5n7vbsuthmd7gi 180 22 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 180 23 functional functional JJ work_zbi2knhp65ho5n7vbsuthmd7gi 180 24 exploration exploration NN work_zbi2knhp65ho5n7vbsuthmd7gi 180 25 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 181 1 Inhibitory inhibitory JJ work_zbi2knhp65ho5n7vbsuthmd7gi 181 2 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 181 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 181 4 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 181 5 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 181 6 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 181 7 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 181 8 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 181 9 prolif- prolif- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 181 10 eration eration NN work_zbi2knhp65ho5n7vbsuthmd7gi 181 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 181 12 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 181 13 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 181 14 surpasses surpass VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 181 15 that that DT work_zbi2knhp65ho5n7vbsuthmd7gi 181 16 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 181 17 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 181 18 Figure Figure NNP work_zbi2knhp65ho5n7vbsuthmd7gi 181 19     _SP work_zbi2knhp65ho5n7vbsuthmd7gi 181 20 7 7 CD work_zbi2knhp65ho5n7vbsuthmd7gi 181 21 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 181 22 comparative comparative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 181 23 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 181 24 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 181 25 chloroquine- chloroquine- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 181 26 vs. vs. FW work_zbi2knhp65ho5n7vbsuthmd7gi 181 27 amodia- amodia- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 181 28 quine quine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 181 29 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 181 30 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 181 31 antiproliferative antiproliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 181 32 effects effect NNS work_zbi2knhp65ho5n7vbsuthmd7gi 181 33 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 182 1 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 182 2 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 182 3 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 182 4 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 182 5 cQ cQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 182 6 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 182 7 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 182 8 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 182 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 182 10 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 182 11 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 182 12 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 182 13 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 182 14 remained remain VBD work_zbi2knhp65ho5n7vbsuthmd7gi 182 15 untreated untreated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 182 16 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 182 17 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 182 18 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 182 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 183 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 183 2 A a DT work_zbi2knhp65ho5n7vbsuthmd7gi 183 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 183 4 Visualization visualization NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 5 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 183 6 transmission transmission NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 7 electron electron NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 8 microscopy microscopy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 183 9 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 183 10 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 183 12 cQ cQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 183 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 183 14 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 183 15 2,650-fold 2,650-fold CD work_zbi2knhp65ho5n7vbsuthmd7gi 183 16 direct direct JJ work_zbi2knhp65ho5n7vbsuthmd7gi 183 17 magnification magnification NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 18 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 183 19 ; ; , work_zbi2knhp65ho5n7vbsuthmd7gi 183 20 cQ cQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 183 21 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 183 22 25,000-fold 25,000-fold CD work_zbi2knhp65ho5n7vbsuthmd7gi 183 23 direct direct JJ work_zbi2knhp65ho5n7vbsuthmd7gi 183 24 magnification magnification NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 25 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 183 26 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 183 27 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 183 28 M m NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 29 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 183 30 mitochondrion mitochondrion NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 31 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 183 32 N n NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 33 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 183 34 nucleus nucleus NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 35 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 183 36 V v NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 37 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 183 38 single single JJ work_zbi2knhp65ho5n7vbsuthmd7gi 183 39 mem- mem- NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 40 brane brane NN work_zbi2knhp65ho5n7vbsuthmd7gi 183 41 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 183 42 enclosed enclose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 183 43 osmiophilic osmiophilic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 183 44 multivesicles multivesicle NNS work_zbi2knhp65ho5n7vbsuthmd7gi 183 45 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 183 46 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 184 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 184 2 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 184 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 184 4 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 184 5 flux flux NN work_zbi2knhp65ho5n7vbsuthmd7gi 184 6 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 184 7 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 184 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 184 9 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 184 10 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 184 11 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 184 12 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 184 13 Lc3 Lc3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 184 14 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 184 15 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 184 16 assay assay NN work_zbi2knhp65ho5n7vbsuthmd7gi 184 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 185 1 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 185 2 transfection transfection NN work_zbi2knhp65ho5n7vbsuthmd7gi 185 3 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 185 4 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 185 5 tandem tandem NN work_zbi2knhp65ho5n7vbsuthmd7gi 185 6 reporter reporter NN work_zbi2knhp65ho5n7vbsuthmd7gi 185 7 construct construct NN work_zbi2knhp65ho5n7vbsuthmd7gi 185 8 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 185 9 RFP- RFP- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 185 10 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 185 11 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 185 12 Lc3 Lc3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 185 13 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 185 14 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 185 15 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 185 16 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 185 17 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 185 18 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 185 19 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 185 20 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 185 21 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 185 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 185 23 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 185 24 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 185 25 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 185 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 185 27 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 185 28 colo- colo- XX work_zbi2knhp65ho5n7vbsuthmd7gi 185 29 calization calization NN work_zbi2knhp65ho5n7vbsuthmd7gi 185 30 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 185 31 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 185 32 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 185 33 Lc3 Lc3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 185 34 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 185 35 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 185 36 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 185 37 Lc3 Lc3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 185 38 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 185 39 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 185 40 examined examine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 185 41 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 185 42 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 185 43 microscopy microscopy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 185 44 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 186 1 Dual dual JJ work_zbi2knhp65ho5n7vbsuthmd7gi 186 2 fluorophore fluorophore NN work_zbi2knhp65ho5n7vbsuthmd7gi 186 3 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 186 4 labeled label VBN work_zbi2knhp65ho5n7vbsuthmd7gi 186 5 Lc3 lc3 NN work_zbi2knhp65ho5n7vbsuthmd7gi 186 6 transfectants transfectant NNS work_zbi2knhp65ho5n7vbsuthmd7gi 186 7 appear appear VBP work_zbi2knhp65ho5n7vbsuthmd7gi 186 8 yellow yellow JJ work_zbi2knhp65ho5n7vbsuthmd7gi 186 9 originating originate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 186 10 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 186 11 overlapping overlap VBG work_zbi2knhp65ho5n7vbsuthmd7gi 186 12 green green JJ work_zbi2knhp65ho5n7vbsuthmd7gi 186 13 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 186 14 red red JJ work_zbi2knhp65ho5n7vbsuthmd7gi 186 15 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 186 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 186 17 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 186 18 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 186 19 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 186 20 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 186 21 autolysosomes autolysosome NNS work_zbi2knhp65ho5n7vbsuthmd7gi 186 22 displaying display VBG work_zbi2knhp65ho5n7vbsuthmd7gi 186 23 impaired impaired JJ work_zbi2knhp65ho5n7vbsuthmd7gi 186 24 acidification acidification NN work_zbi2knhp65ho5n7vbsuthmd7gi 186 25 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 187 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 187 2 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 187 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 187 4 Loss Loss NNP work_zbi2knhp65ho5n7vbsuthmd7gi 187 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 187 6 cathepsin cathepsin NN work_zbi2knhp65ho5n7vbsuthmd7gi 187 7 enzymatic enzymatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 187 8 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 187 9 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 187 10 cTsB cTsB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 187 11 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 187 12 cTsL cTsL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 187 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 187 14 cTsD cTsD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 187 15 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 187 16 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 187 17 a375 a375 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 187 18 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 187 19 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 187 20 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 187 21 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 187 22 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 187 23 ≤ ≤ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 187 24 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 187 25 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 187 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 187 27 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 187 28 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 187 29 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 187 30 detected detect VBD work_zbi2knhp65ho5n7vbsuthmd7gi 187 31 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 187 32 described describe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 187 33 above above RB work_zbi2knhp65ho5n7vbsuthmd7gi 187 34 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 188 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 188 2 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 188 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 188 4 comparative comparative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 188 5 potency potency NN work_zbi2knhp65ho5n7vbsuthmd7gi 188 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 188 7 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 188 8 vs. vs. IN work_zbi2knhp65ho5n7vbsuthmd7gi 188 9 cQ cQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 188 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 188 11 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 188 12 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 188 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 188 14 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 188 15 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 188 16 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 188 17 inhibiting inhibit VBG work_zbi2knhp65ho5n7vbsuthmd7gi 188 18 cTsB cTsB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 188 19 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 188 20 cTsL cTsL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 188 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 188 22 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 188 23 cTsD cTsD VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 188 24 enzymatic enzymatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 188 25 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 188 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 189 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 189 2 E e NN work_zbi2knhp65ho5n7vbsuthmd7gi 189 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 189 4 aQ- aQ- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 189 5 vs. vs. IN work_zbi2knhp65ho5n7vbsuthmd7gi 189 6 cQ cQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 189 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 189 8 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 189 9 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 189 10 ≤ ≤ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 189 11 25 25 CD work_zbi2knhp65ho5n7vbsuthmd7gi 189 12 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 189 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 189 14 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 189 15 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 189 16 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 189 17 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 189 18 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 189 19 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 189 20 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 189 21 mRNa mRNa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 189 22 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 189 23 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 189 24 a375 a375 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 189 25 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 189 26 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 189 27 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 190 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 190 2 F f NN work_zbi2knhp65ho5n7vbsuthmd7gi 190 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 190 4 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 190 5 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 190 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 190 7 cQ- cQ- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 190 8 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 190 9 aQ aQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 190 10 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 190 11 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 190 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 190 13 ≤ ≤ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 190 14 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 190 15 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 190 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 190 17 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 190 18 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 190 19 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 190 20 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 190 21 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 190 22 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 190 23 TP53 tp53 IN work_zbi2knhp65ho5n7vbsuthmd7gi 190 24 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 190 25 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 191 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 191 2 G g NN work_zbi2knhp65ho5n7vbsuthmd7gi 191 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 191 4 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 191 5 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 191 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 191 7 cQ cq NN work_zbi2knhp65ho5n7vbsuthmd7gi 191 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 191 9 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 191 10 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 191 11 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 191 12 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 191 13 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 191 14 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 191 15 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 191 16 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 191 17 a375 a375 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 191 18 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 191 19 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 191 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 192 1 © © LS work_zbi2knhp65ho5n7vbsuthmd7gi 192 2 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 192 3 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 192 4 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 192 5 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 192 6 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 192 7 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 192 8 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 192 9 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 192 10 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 192 11 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 192 12 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 192 13 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 192 14 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 192 15 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 192 16 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 192 17 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 192 18 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 192 19 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 192 20 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 192 21 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 192 22 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 192 23 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 192 24 2096 2096 CD work_zbi2knhp65ho5n7vbsuthmd7gi 192 25 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 192 26 Volume Volume NNP work_zbi2knhp65ho5n7vbsuthmd7gi 192 27 9 9 CD work_zbi2knhp65ho5n7vbsuthmd7gi 192 28 issue issue NN work_zbi2knhp65ho5n7vbsuthmd7gi 192 29 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 192 30 After after IN work_zbi2knhp65ho5n7vbsuthmd7gi 192 31 investigating investigate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 192 32 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 192 33 antimelanoma antimelanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 192 34 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 192 35 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 192 36 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 192 37 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 192 38 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 192 39 com- com- RB work_zbi2knhp65ho5n7vbsuthmd7gi 192 40 pared pare VBD work_zbi2knhp65ho5n7vbsuthmd7gi 192 41 chemotherapeutic chemotherapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 192 42 efficacy efficacy NN work_zbi2knhp65ho5n7vbsuthmd7gi 192 43 between between IN work_zbi2knhp65ho5n7vbsuthmd7gi 192 44 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 192 45 4-aminoquinoline 4-aminoquinoline CD work_zbi2knhp65ho5n7vbsuthmd7gi 192 46 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 192 47 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 192 48 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 192 49 its -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 192 50 parent parent NN work_zbi2knhp65ho5n7vbsuthmd7gi 192 51 compound compound NN work_zbi2knhp65ho5n7vbsuthmd7gi 192 52 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 192 53 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 192 54 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 192 55 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 193 1 6E 6e NN work_zbi2knhp65ho5n7vbsuthmd7gi 193 2 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 193 3 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 193 4 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 194 1 7 7 LS work_zbi2knhp65ho5n7vbsuthmd7gi 194 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 194 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 195 1 First first RB work_zbi2knhp65ho5n7vbsuthmd7gi 195 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 195 3 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 195 4 compared compare VBD work_zbi2knhp65ho5n7vbsuthmd7gi 195 5 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 195 6 potency potency NN work_zbi2knhp65ho5n7vbsuthmd7gi 195 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 195 8 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 195 9 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 195 10 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 195 11 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 195 12 displayed display VBN work_zbi2knhp65ho5n7vbsuthmd7gi 195 13 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 195 14 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 195 15 vs. vs. IN work_zbi2knhp65ho5n7vbsuthmd7gi 195 16 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 195 17 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 195 18 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 195 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 196 1 6E 6E NNP work_zbi2knhp65ho5n7vbsuthmd7gi 196 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 196 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 197 1 A a DT work_zbi2knhp65ho5n7vbsuthmd7gi 197 2 comparative comparative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 197 3 dose dose NN work_zbi2knhp65ho5n7vbsuthmd7gi 197 4 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 197 5 relationship relationship NN work_zbi2knhp65ho5n7vbsuthmd7gi 197 6 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 197 7 performed perform VBN work_zbi2knhp65ho5n7vbsuthmd7gi 197 8 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 197 9 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 197 11 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 12 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 197 13 IC IC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 14 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 15 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 197 16 0.32 0.32 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 17 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 18 0.12 0.12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 19 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 20 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 197 21 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 22 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 197 23 IC IC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 24 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 25 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 197 26 2.81 2.81 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 27 ± ± CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 28 0.44 0.44 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 29 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 30 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 197 31 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 197 32 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 33 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 197 34 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 35 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 197 36 IC IC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 37 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 38 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 197 39 0.71 0.71 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 40 ± ± CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 41 0.16 0.16 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 42 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 43 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 197 44 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 45 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 197 46 IC IC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 47 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 48 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 197 49 12.63 12.63 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 50 ± ± CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 51 2.55 2.55 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 52 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 53 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 197 54 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 197 55 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 197 56 LOX LOX NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 57 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 197 58 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 59 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 197 60 IC IC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 61 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 62 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 197 63 2.60 2.60 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 64 ± ± CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 65 0.74 0.74 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 66 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 197 67 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 68 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 197 69 IC IC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 70 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 71 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 197 72 8.38 8.38 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 73 ± ± CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 74 0.93 0.93 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 75 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 76 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 197 77 mean mean NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 78 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 79 SD sd NN work_zbi2knhp65ho5n7vbsuthmd7gi 197 80 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 197 81 n n NN work_zbi2knhp65ho5n7vbsuthmd7gi 197 82 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 197 83 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 84 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 197 85 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 197 86 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 197 87 identified identify VBN work_zbi2knhp65ho5n7vbsuthmd7gi 197 88 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 89 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 197 90 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 197 91 superior superior JJ work_zbi2knhp65ho5n7vbsuthmd7gi 197 92 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 197 93 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 197 94 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 197 95 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 197 96 proliferation proliferation NN work_zbi2knhp65ho5n7vbsuthmd7gi 197 97 among among IN work_zbi2knhp65ho5n7vbsuthmd7gi 197 98 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 197 99 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 100 tested test VBN work_zbi2knhp65ho5n7vbsuthmd7gi 197 101 4-aminoquinoline 4-aminoquinoline CD work_zbi2knhp65ho5n7vbsuthmd7gi 197 102 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 197 103 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 198 1 Next next RB work_zbi2knhp65ho5n7vbsuthmd7gi 198 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 198 3 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 198 4 examined examine VBD work_zbi2knhp65ho5n7vbsuthmd7gi 198 5 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 198 6 induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 198 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 198 8 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 198 9 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 198 10 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 198 11 impairment impairment NN work_zbi2knhp65ho5n7vbsuthmd7gi 198 12 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 198 13 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 198 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 198 15 treated treat VBN work_zbi2knhp65ho5n7vbsuthmd7gi 198 16 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 198 17 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 198 18 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 198 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 199 1 We -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 199 2 observed observe VBD work_zbi2knhp65ho5n7vbsuthmd7gi 199 3 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 199 4 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 199 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 199 6 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 199 7 morphological morphological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 199 8 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 199 9 examined examine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 199 10 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 199 11 trans- trans- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 199 12 mission mission NNP work_zbi2knhp65ho5n7vbsuthmd7gi 199 13 electron electron NNP work_zbi2knhp65ho5n7vbsuthmd7gi 199 14 microscopy microscopy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 199 15 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 199 16 similar similar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 199 17 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 199 18 those those DT work_zbi2knhp65ho5n7vbsuthmd7gi 199 19 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 199 20 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 199 21 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 199 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 199 23 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 199 24 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 199 25 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 199 26 multivesicular multivesicular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 199 27 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 199 28 single single JJ work_zbi2knhp65ho5n7vbsuthmd7gi 199 29 membrane- membrane- NN work_zbi2knhp65ho5n7vbsuthmd7gi 199 30 enclosed enclose VBD work_zbi2knhp65ho5n7vbsuthmd7gi 199 31 structures structure NNS work_zbi2knhp65ho5n7vbsuthmd7gi 199 32 containing contain VBG work_zbi2knhp65ho5n7vbsuthmd7gi 199 33 electron electron NN work_zbi2knhp65ho5n7vbsuthmd7gi 199 34 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 199 35 dense dense JJ work_zbi2knhp65ho5n7vbsuthmd7gi 199 36 osmiophilic osmiophilic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 199 37 inclu- inclu- NNS work_zbi2knhp65ho5n7vbsuthmd7gi 199 38 sions sion NNS work_zbi2knhp65ho5n7vbsuthmd7gi 199 39 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 199 40 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 199 41 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 200 1 7A 7a NN work_zbi2knhp65ho5n7vbsuthmd7gi 200 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 200 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 201 1 However however RB work_zbi2knhp65ho5n7vbsuthmd7gi 201 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 201 3 morphological morphological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 201 4 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 201 5 elicited elicit VBN work_zbi2knhp65ho5n7vbsuthmd7gi 201 6 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 201 7 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 201 8 seemed seem VBD work_zbi2knhp65ho5n7vbsuthmd7gi 201 9 less less RBR work_zbi2knhp65ho5n7vbsuthmd7gi 201 10 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 201 11 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 201 12 number number NN work_zbi2knhp65ho5n7vbsuthmd7gi 201 13 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 201 14 size size NN work_zbi2knhp65ho5n7vbsuthmd7gi 201 15 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 201 16 multivesicular multivesicular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 201 17 struc- struc- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 201 18 tures ture NNS work_zbi2knhp65ho5n7vbsuthmd7gi 201 19 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 201 20 compared compare VBN work_zbi2knhp65ho5n7vbsuthmd7gi 201 21 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 201 22 those those DT work_zbi2knhp65ho5n7vbsuthmd7gi 201 23 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 201 24 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 201 25 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 201 26 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 201 27 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 201 28 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 201 29 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 202 1 1C 1C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 202 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 202 3 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 202 4 vs. vs. NN work_zbi2knhp65ho5n7vbsuthmd7gi 203 1 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 203 2 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 204 1 7A 7a NN work_zbi2knhp65ho5n7vbsuthmd7gi 204 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 204 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 205 1 Further further JJ work_zbi2knhp65ho5n7vbsuthmd7gi 205 2 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 205 3 revealed reveal VBD work_zbi2knhp65ho5n7vbsuthmd7gi 205 4 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 205 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 205 6 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 205 7 effects effect NNS work_zbi2knhp65ho5n7vbsuthmd7gi 205 8 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 205 9 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 205 10 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 205 11 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 205 12 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 205 13 similar similar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 205 14 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 205 15 those those DT work_zbi2knhp65ho5n7vbsuthmd7gi 205 16 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 205 17 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 205 18 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 205 19 monitoring monitor VBG work_zbi2knhp65ho5n7vbsuthmd7gi 205 20 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 205 21 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 205 22 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 205 23 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 205 24 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 205 25 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 205 26 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 205 27 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 205 28 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 205 29 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 206 1 7B 7B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 206 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 206 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 207 1 As as IN work_zbi2knhp65ho5n7vbsuthmd7gi 207 2 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 207 3 earlier early RBR work_zbi2knhp65ho5n7vbsuthmd7gi 207 4 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 207 5 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 207 6 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 207 7 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 207 8 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 208 1 2D 2D VBN work_zbi2knhp65ho5n7vbsuthmd7gi 208 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 208 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 208 4 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 5 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 208 6 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 208 7 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 208 8 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 9 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 208 10 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 208 11 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 12 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 208 13 displayed display VBD work_zbi2knhp65ho5n7vbsuthmd7gi 208 14 both both DT work_zbi2knhp65ho5n7vbsuthmd7gi 208 15 green green JJ work_zbi2knhp65ho5n7vbsuthmd7gi 208 16 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 208 17 red red JJ work_zbi2knhp65ho5n7vbsuthmd7gi 208 18 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 19 producing produce VBG work_zbi2knhp65ho5n7vbsuthmd7gi 208 20 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 208 21 yellow yellow JJ work_zbi2knhp65ho5n7vbsuthmd7gi 208 22 overlay overlay NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 208 24 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 208 25 finding finding NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 26 consistent consistent NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 27 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 208 28 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 208 29 established establish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 208 30 ability ability NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 31 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 208 32 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 208 33 lysosomotropic lysosomotropic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 208 34 agent agent NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 35 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 208 36 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 208 37 induce induce VB work_zbi2knhp65ho5n7vbsuthmd7gi 208 38 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 208 39 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 208 40 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 208 41 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 42 through through IN work_zbi2knhp65ho5n7vbsuthmd7gi 208 43 impairment impairment NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 44 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 208 45 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 208 46 pH ph NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 47 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 208 48 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 49 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 208 50 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 51 thereby thereby RB work_zbi2knhp65ho5n7vbsuthmd7gi 208 52 inducing induce VBG work_zbi2knhp65ho5n7vbsuthmd7gi 208 53 accumu- accumu- FW work_zbi2knhp65ho5n7vbsuthmd7gi 208 54 lation lation NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 55 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 208 56 dysfunctional dysfunctional JJ work_zbi2knhp65ho5n7vbsuthmd7gi 208 57 autolysosomes autolysosome NNS work_zbi2knhp65ho5n7vbsuthmd7gi 208 58 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 208 59 colocalization colocalization NN work_zbi2knhp65ho5n7vbsuthmd7gi 208 60 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 208 61 GFP- GFP- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 208 62 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 208 63 RRP RRP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 208 64 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 208 65 labeled label VBN work_zbi2knhp65ho5n7vbsuthmd7gi 208 66 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 208 67 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 209 1 Immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 209 2 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 209 3 demonstrated demonstrate VBD work_zbi2knhp65ho5n7vbsuthmd7gi 209 4 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 209 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 209 6 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 209 7 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 209 8 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 209 9 LAMP1 LAMP1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 209 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 209 11 LC3-II LC3-II NNP work_zbi2knhp65ho5n7vbsuthmd7gi 209 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 209 13 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 209 14 SQSTM1 SQSTM1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 209 15 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 209 16 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 209 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 210 1 7 7 CD work_zbi2knhp65ho5n7vbsuthmd7gi 210 2 G g NN work_zbi2knhp65ho5n7vbsuthmd7gi 210 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 210 4 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 210 5 changes change VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 210 6 similar similar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 210 7 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 210 8 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 210 9 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 210 10 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 210 11 alterations alteration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 210 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 210 13 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 210 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 211 1 2A 2A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 211 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 211 3 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 211 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 211 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 212 1 Moreover moreover RB work_zbi2knhp65ho5n7vbsuthmd7gi 212 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 212 3 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 212 4 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 212 5 prior prior JJ work_zbi2knhp65ho5n7vbsuthmd7gi 212 6 reports report NNS work_zbi2knhp65ho5n7vbsuthmd7gi 212 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 212 8 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 212 9 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 212 10 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 212 11 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 212 12 significant significant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 212 13 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 212 14 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 212 15 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 212 16 cathepsin cathepsin NN work_zbi2knhp65ho5n7vbsuthmd7gi 212 17 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 212 18 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 212 19 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 212 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 212 21 CTSL CTSL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 212 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 212 23 CTSD CTSD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 212 24 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 212 25 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 212 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 213 1 7C 7C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 213 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 213 3 D).72 D).72 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 213 4 Importantly importantly RB work_zbi2knhp65ho5n7vbsuthmd7gi 213 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 213 6 when when WRB work_zbi2knhp65ho5n7vbsuthmd7gi 213 7 cathepsin cathepsin NN work_zbi2knhp65ho5n7vbsuthmd7gi 213 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 213 9 directed direct VBN work_zbi2knhp65ho5n7vbsuthmd7gi 213 10 inhibitory inhibitory JJ work_zbi2knhp65ho5n7vbsuthmd7gi 213 11 effects effect NNS work_zbi2knhp65ho5n7vbsuthmd7gi 213 12 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 213 13 compared compare VBN work_zbi2knhp65ho5n7vbsuthmd7gi 213 14 between between IN work_zbi2knhp65ho5n7vbsuthmd7gi 213 15 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 213 16 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 213 17 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 213 18 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 213 19 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 213 20 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 213 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 213 22 each each DT work_zbi2knhp65ho5n7vbsuthmd7gi 213 23 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 213 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 213 25 it -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 213 26 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 213 27 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 213 28 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 213 29 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 213 30 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 213 31 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 213 32 more more RBR work_zbi2knhp65ho5n7vbsuthmd7gi 213 33 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 213 34 reduction reduction NN work_zbi2knhp65ho5n7vbsuthmd7gi 213 35 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 213 36 CTSL CTSL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 213 37 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 213 38 CTSD ctsd JJ work_zbi2knhp65ho5n7vbsuthmd7gi 213 39 enzymatic enzymatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 213 40 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 213 41 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 213 42 whereas whereas IN work_zbi2knhp65ho5n7vbsuthmd7gi 213 43 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 213 44 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 213 45 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 213 46 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 213 47 equally equally RB work_zbi2knhp65ho5n7vbsuthmd7gi 213 48 effective effective JJ work_zbi2knhp65ho5n7vbsuthmd7gi 213 49 antagoniz- antagoniz- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 213 50 ing e VBG work_zbi2knhp65ho5n7vbsuthmd7gi 213 51 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 213 52 enzymatic enzymatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 213 53 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 213 54 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 213 55 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 213 56 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 214 1 7D 7D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 214 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 214 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 215 1 Differential differential NN work_zbi2knhp65ho5n7vbsuthmd7gi 215 2 suppres- suppres- NN work_zbi2knhp65ho5n7vbsuthmd7gi 215 3 sion sion NN work_zbi2knhp65ho5n7vbsuthmd7gi 215 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 215 5 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 215 6 cathepsin cathepsin NN work_zbi2knhp65ho5n7vbsuthmd7gi 215 7 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 215 8 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 215 9 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 215 10 vs. vs. IN work_zbi2knhp65ho5n7vbsuthmd7gi 215 11 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 215 12 correlates correlate VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 215 13 well well RB work_zbi2knhp65ho5n7vbsuthmd7gi 215 14 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 215 15 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 215 16 occurrence occurrence NN work_zbi2knhp65ho5n7vbsuthmd7gi 215 17 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 215 18 more more RBR work_zbi2knhp65ho5n7vbsuthmd7gi 215 19 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 215 20 morphological morphological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 215 21 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 215 22 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 215 23 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 215 24 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 215 25 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 215 26 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 215 27 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 215 28 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 215 29 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 215 30 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 215 31 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 215 32 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 215 33 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 215 34 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 215 35 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 216 1 1C 1C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 216 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 216 3 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 216 4 vs. vs. NN work_zbi2knhp65ho5n7vbsuthmd7gi 217 1 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 217 2 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 218 1 7A 7a NN work_zbi2knhp65ho5n7vbsuthmd7gi 218 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 218 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 219 1 After after IN work_zbi2knhp65ho5n7vbsuthmd7gi 219 2 identifying identify VBG work_zbi2knhp65ho5n7vbsuthmd7gi 219 3 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 219 4 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 219 5 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 219 6 superior superior JJ work_zbi2knhp65ho5n7vbsuthmd7gi 219 7 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 219 8 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 219 9 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 219 10 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 219 11 proliferation proliferation NN work_zbi2knhp65ho5n7vbsuthmd7gi 219 12 among among IN work_zbi2knhp65ho5n7vbsuthmd7gi 219 13 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 219 14 two two CD work_zbi2knhp65ho5n7vbsuthmd7gi 219 15 tested test VBN work_zbi2knhp65ho5n7vbsuthmd7gi 219 16 4-aminoquinoline 4-aminoquinoline CD work_zbi2knhp65ho5n7vbsuthmd7gi 219 17 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 219 18 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 219 19 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 219 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 220 1 6E 6E NNP work_zbi2knhp65ho5n7vbsuthmd7gi 220 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 220 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 220 4 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 220 5 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 220 6 performed perform VBD work_zbi2knhp65ho5n7vbsuthmd7gi 220 7 comparative comparative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 220 8 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 220 9 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 220 10 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 220 11 indicating indicate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 220 12 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 220 13 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 220 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 220 15 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 220 16 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 220 17 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 220 18 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 220 19 mRNA mrna JJ work_zbi2knhp65ho5n7vbsuthmd7gi 220 20 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 220 21 did do VBD work_zbi2knhp65ho5n7vbsuthmd7gi 220 22 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 220 23 match match VB work_zbi2knhp65ho5n7vbsuthmd7gi 220 24 those those DT work_zbi2knhp65ho5n7vbsuthmd7gi 220 25 detected detect VBN work_zbi2knhp65ho5n7vbsuthmd7gi 220 26 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 220 27 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 220 28 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 220 29 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 220 30 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 220 31 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 220 32 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 221 1 7E 7E NNP work_zbi2knhp65ho5n7vbsuthmd7gi 221 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 221 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 222 1 Specifically specifically RB work_zbi2knhp65ho5n7vbsuthmd7gi 222 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 222 3 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 222 4 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 222 5 failed fail VBD work_zbi2knhp65ho5n7vbsuthmd7gi 222 6 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 222 7 change change VB work_zbi2knhp65ho5n7vbsuthmd7gi 222 8 expres- expres- VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 222 9 sion sion NN work_zbi2knhp65ho5n7vbsuthmd7gi 222 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 222 11 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 222 12 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 222 13 responsive responsive JJ work_zbi2knhp65ho5n7vbsuthmd7gi 222 14 key key JJ work_zbi2knhp65ho5n7vbsuthmd7gi 222 15 genes gene NNS work_zbi2knhp65ho5n7vbsuthmd7gi 222 16 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 222 17 DDIT3 DDIT3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 222 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 222 19 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 222 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 222 21 GADD45A GADD45A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 222 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 222 23 EGR1 EGR1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 222 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 222 25 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 222 26 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 222 27 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 223 1 Consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 223 2 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 223 3 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 223 4 inferior inferior JJ work_zbi2knhp65ho5n7vbsuthmd7gi 223 5 anti- anti- NN work_zbi2knhp65ho5n7vbsuthmd7gi 223 6 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 223 7 potency potency NN work_zbi2knhp65ho5n7vbsuthmd7gi 223 8 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 223 9 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 223 10 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 223 11 compared compare VBN work_zbi2knhp65ho5n7vbsuthmd7gi 223 12 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 223 13 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 223 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 223 15 subsequent subsequent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 223 16 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 223 17 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 223 18 demonstrated demonstrate VBD work_zbi2knhp65ho5n7vbsuthmd7gi 223 19 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 223 20 even even RB work_zbi2knhp65ho5n7vbsuthmd7gi 223 21 though though IN work_zbi2knhp65ho5n7vbsuthmd7gi 223 22 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 223 23 treat- treat- NN work_zbi2knhp65ho5n7vbsuthmd7gi 223 24 ment ment NN work_zbi2knhp65ho5n7vbsuthmd7gi 223 25 caused cause VBD work_zbi2knhp65ho5n7vbsuthmd7gi 223 26 moderate moderate JJ work_zbi2knhp65ho5n7vbsuthmd7gi 223 27 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 223 28 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 223 29 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 223 30 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 223 31 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 223 32 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 223 33 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 223 34 failed fail VBD work_zbi2knhp65ho5n7vbsuthmd7gi 223 35 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 223 36 alter alter VB work_zbi2knhp65ho5n7vbsuthmd7gi 223 37 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 223 38 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 223 39 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 223 40 TP53 TP53 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 223 41 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 223 42 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 223 43 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 223 44 CCND1 CCND1 '' work_zbi2knhp65ho5n7vbsuthmd7gi 223 45 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 223 46 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 223 47 HSPA1A hspa1a UH work_zbi2knhp65ho5n7vbsuthmd7gi 223 48 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 223 49 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 223 50 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 223 51 earlier early RBR work_zbi2knhp65ho5n7vbsuthmd7gi 223 52 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 223 53 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 223 54 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 223 55 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 223 56 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 223 57 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 223 58 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 223 59 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 224 1 7F 7f LS work_zbi2knhp65ho5n7vbsuthmd7gi 224 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 224 3 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 224 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 224 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 225 1 Indeed indeed RB work_zbi2knhp65ho5n7vbsuthmd7gi 225 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 225 3 further further JJ work_zbi2knhp65ho5n7vbsuthmd7gi 225 4 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 225 5 indicated indicate VBD work_zbi2knhp65ho5n7vbsuthmd7gi 225 6 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 225 7 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 225 8 treat- treat- NN work_zbi2knhp65ho5n7vbsuthmd7gi 225 9 ment ment NN work_zbi2knhp65ho5n7vbsuthmd7gi 225 10 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 225 11 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 225 12 associated associate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 225 13 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 225 14 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 225 15 induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 225 16 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 225 17 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 225 18 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 225 19 arrest arrest NN work_zbi2knhp65ho5n7vbsuthmd7gi 225 20 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 225 21 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 225 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 226 1 8) 8) CD work_zbi2knhp65ho5n7vbsuthmd7gi 226 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 226 3 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 226 4 observation observation NN work_zbi2knhp65ho5n7vbsuthmd7gi 226 5 strikingly strikingly RB work_zbi2knhp65ho5n7vbsuthmd7gi 226 6 different different JJ work_zbi2knhp65ho5n7vbsuthmd7gi 226 7 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 226 8 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 226 9 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 226 10 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 226 11 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 226 12 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 226 13 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 226 14 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 226 15 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 226 16 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 226 17 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 226 18 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 226 19 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 226 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 227 1 6D 6d NN work_zbi2knhp65ho5n7vbsuthmd7gi 227 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 227 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 228 1 Discussion Discussion NNP work_zbi2knhp65ho5n7vbsuthmd7gi 228 2 Pharmacological Pharmacological NNP work_zbi2knhp65ho5n7vbsuthmd7gi 228 3 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 228 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 228 5 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 6 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 228 7 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 8 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 228 9 has have VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 228 10 recently recently RB work_zbi2knhp65ho5n7vbsuthmd7gi 228 11 emerged emerge VBN work_zbi2knhp65ho5n7vbsuthmd7gi 228 12 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 228 13 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 228 14 promising promising JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 15 strategy strategy NN work_zbi2knhp65ho5n7vbsuthmd7gi 228 16 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 228 17 chemothera- chemothera- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 18 peutic peutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 19 intervention intervention NN work_zbi2knhp65ho5n7vbsuthmd7gi 228 20 targeting target VBG work_zbi2knhp65ho5n7vbsuthmd7gi 228 21 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 228 22 cells.4,5,9,13 cells.4,5,9,13 , work_zbi2knhp65ho5n7vbsuthmd7gi 228 23 - - : work_zbi2knhp65ho5n7vbsuthmd7gi 228 24 15 15 CD work_zbi2knhp65ho5n7vbsuthmd7gi 228 25 Even even RB work_zbi2knhp65ho5n7vbsuthmd7gi 228 26 though though IN work_zbi2knhp65ho5n7vbsuthmd7gi 228 27 numerous numerous JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 28 ongoing ongoing JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 29 clinical clinical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 30 trials trial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 228 31 aim aim VBP work_zbi2knhp65ho5n7vbsuthmd7gi 228 32 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 228 33 substantiating substantiate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 228 34 favorable favorable JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 35 therapeutic therapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 36 effects effect NNS work_zbi2knhp65ho5n7vbsuthmd7gi 228 37 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 228 38 chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 228 39 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 228 40 hydroxychloroquine hydroxychloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 228 41 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 228 42 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 228 43 limited limited JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 44 therapeutic therapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 45 performance performance NN work_zbi2knhp65ho5n7vbsuthmd7gi 228 46 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 228 47 these these DT work_zbi2knhp65ho5n7vbsuthmd7gi 228 48 lysosomotropic lysosomotropic NNP work_zbi2knhp65ho5n7vbsuthmd7gi 228 49 4-ami- 4-ami- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 228 50 noquinoline noquinoline NN work_zbi2knhp65ho5n7vbsuthmd7gi 228 51 derivatives derivative NNS work_zbi2knhp65ho5n7vbsuthmd7gi 228 52 prompted prompt VBD work_zbi2knhp65ho5n7vbsuthmd7gi 228 53 us -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 228 54 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 228 55 explore explore VB work_zbi2knhp65ho5n7vbsuthmd7gi 228 56 other other JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 57 promising promising JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 58 drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 228 59 candidates candidate NNS work_zbi2knhp65ho5n7vbsuthmd7gi 228 60 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 228 61 target target VBP work_zbi2knhp65ho5n7vbsuthmd7gi 228 62 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 63 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 228 64 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 228 65 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 228 66 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 228 67 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 228 68 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 228 69 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 229 1 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 229 2 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 229 3 study study NN work_zbi2knhp65ho5n7vbsuthmd7gi 229 4 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 229 5 have have VBP work_zbi2knhp65ho5n7vbsuthmd7gi 229 6 examined examine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 229 7 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 229 8 antimelanoma antimelanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 229 9 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 229 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 229 11 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 229 12 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 229 13 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 229 14 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 229 15 have have VBP work_zbi2knhp65ho5n7vbsuthmd7gi 229 16 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 229 17 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 229 18 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 229 19 cultured cultured JJ work_zbi2knhp65ho5n7vbsuthmd7gi 229 20 malig- malig- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 229 21 nant nant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 229 22 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 229 23 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 229 24 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 229 25 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 229 26 pronounced pronounce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 229 27 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 229 28 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 229 29 lyso- lyso- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 229 30 somal somal NN work_zbi2knhp65ho5n7vbsuthmd7gi 229 31 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 229 32 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 229 33 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 229 34 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 229 35 surpasses surpass VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 229 36 that that DT work_zbi2knhp65ho5n7vbsuthmd7gi 229 37 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 229 38 its -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 229 39 parent parent NN work_zbi2knhp65ho5n7vbsuthmd7gi 229 40 compound compound NN work_zbi2knhp65ho5n7vbsuthmd7gi 229 41 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 229 42 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 230 1 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 230 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 230 3 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 230 4 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 230 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 230 6 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 230 7 antagonism antagonism NN work_zbi2knhp65ho5n7vbsuthmd7gi 230 8 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 230 9 associated associate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 230 10 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 230 11 early early JJ work_zbi2knhp65ho5n7vbsuthmd7gi 230 12 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 230 13 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 230 14 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 230 15 enzymatic enzymatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 230 16 activ- activ- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 230 17 ity ity NN work_zbi2knhp65ho5n7vbsuthmd7gi 230 18 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 230 19 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 230 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 230 21 CTSL CTSL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 230 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 230 23 CTSD CTSD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 230 24 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 230 25 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 230 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 231 1 3B 3B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 231 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 231 3 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 231 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 231 5 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 231 6 ATP atp NN work_zbi2knhp65ho5n7vbsuthmd7gi 231 7 depletion depletion NN work_zbi2knhp65ho5n7vbsuthmd7gi 231 8 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 231 9 Figure Figure NNP work_zbi2knhp65ho5n7vbsuthmd7gi 231 10     _SP work_zbi2knhp65ho5n7vbsuthmd7gi 231 11 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 231 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 231 13 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 231 14 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 231 15 cQ cQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 231 16 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 231 17 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 231 18 alterations alteration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 231 19 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 231 20 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 231 21 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 231 22 distribution distribution NN work_zbi2knhp65ho5n7vbsuthmd7gi 231 23 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 232 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 232 2 A a DT work_zbi2knhp65ho5n7vbsuthmd7gi 232 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 232 4 Representative Representative NNP work_zbi2knhp65ho5n7vbsuthmd7gi 232 5 histogram histogram NN work_zbi2knhp65ho5n7vbsuthmd7gi 232 6 depicting depict VBG work_zbi2knhp65ho5n7vbsuthmd7gi 232 7 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 232 8 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 232 9 distribution distribution NN work_zbi2knhp65ho5n7vbsuthmd7gi 232 10 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 232 11 treat- treat- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 232 12 ment ment NN work_zbi2knhp65ho5n7vbsuthmd7gi 232 13 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 232 14 cQ cQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 232 15 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 232 16 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 232 17 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 232 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 232 19 ≤ ≤ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 232 20 48 48 CD work_zbi2knhp65ho5n7vbsuthmd7gi 232 21 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 232 22 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 232 23 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 233 1 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 233 2 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 233 3 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 233 4 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 233 5 indicated indicate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 233 6 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 233 7 peri- peri- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 233 8 ods od NNS work_zbi2knhp65ho5n7vbsuthmd7gi 233 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 233 10 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 233 11 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 233 12 stained stain VBN work_zbi2knhp65ho5n7vbsuthmd7gi 233 13 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 233 14 Pi Pi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 233 15 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 233 16 analyzed analyze VBN work_zbi2knhp65ho5n7vbsuthmd7gi 233 17 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 233 18 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 233 19 cytometry cytometry NN work_zbi2knhp65ho5n7vbsuthmd7gi 233 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 234 1 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 234 2 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 234 3 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 234 4 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 234 5 data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 234 6 indicate indicate VBP work_zbi2knhp65ho5n7vbsuthmd7gi 234 7 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 234 8 percentage percentage NN work_zbi2knhp65ho5n7vbsuthmd7gi 234 9 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 234 10 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 234 11 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 234 12 each each DT work_zbi2knhp65ho5n7vbsuthmd7gi 234 13 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 234 14 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 234 15 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 234 16 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 234 17 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 234 18 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 234 19 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 234 20 table table NN work_zbi2knhp65ho5n7vbsuthmd7gi 234 21 summarizes summarize VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 234 22 results result NNS work_zbi2knhp65ho5n7vbsuthmd7gi 234 23 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 234 24 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 234 25 independent independent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 234 26 repeat repeat NN work_zbi2knhp65ho5n7vbsuthmd7gi 234 27 experiments experiment NNS work_zbi2knhp65ho5n7vbsuthmd7gi 234 28 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 234 29 mean mean VB work_zbi2knhp65ho5n7vbsuthmd7gi 234 30 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 234 31 sD sD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 234 32 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 234 33 n n NN work_zbi2knhp65ho5n7vbsuthmd7gi 234 34 = = SYM work_zbi2knhp65ho5n7vbsuthmd7gi 234 35 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 234 36 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 234 37 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 234 38 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 235 1 © © LS work_zbi2knhp65ho5n7vbsuthmd7gi 235 2 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 235 3 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 235 4 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 235 5 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 235 6 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 235 7 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 235 8 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 235 9 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 235 10 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 235 11 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 235 12 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 235 13 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 235 14 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 235 15 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 235 16 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 235 17 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 235 18 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 235 19 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 235 20 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 235 21 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 235 22 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 235 23 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 235 24 www.landesbioscience.com www.landesbioscience.com NNP work_zbi2knhp65ho5n7vbsuthmd7gi 235 25 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 235 26 2097 2097 CD work_zbi2knhp65ho5n7vbsuthmd7gi 235 27 both both CC work_zbi2knhp65ho5n7vbsuthmd7gi 235 28 detectable detectable JJ work_zbi2knhp65ho5n7vbsuthmd7gi 235 29 within within IN work_zbi2knhp65ho5n7vbsuthmd7gi 235 30 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 235 31 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 235 32 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 235 33 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 235 34 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 235 35 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 235 36 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 236 1 4B 4B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 236 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 236 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 237 1 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 237 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 237 3 imposed impose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 237 4 impairment impairment NN work_zbi2knhp65ho5n7vbsuthmd7gi 237 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 237 6 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 237 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 237 8 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 237 9 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 237 10 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 237 11 further further RB work_zbi2knhp65ho5n7vbsuthmd7gi 237 12 sub- sub- DT work_zbi2knhp65ho5n7vbsuthmd7gi 237 13 stantiated stantiate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 237 14 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 237 15 ultrastructural ultrastructural JJ work_zbi2knhp65ho5n7vbsuthmd7gi 237 16 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 237 17 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 237 18 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 237 19 electron electron NNP work_zbi2knhp65ho5n7vbsuthmd7gi 237 20 microscopy microscopy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 237 21 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 237 22 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 237 23 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 238 1 1 1 LS work_zbi2knhp65ho5n7vbsuthmd7gi 238 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 238 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 238 4 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 238 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 238 6 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 238 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 238 8 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 238 9 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 238 10 imaging imaging NN work_zbi2knhp65ho5n7vbsuthmd7gi 238 11 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 238 12 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 238 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 239 1 2D 2D VBN work_zbi2knhp65ho5n7vbsuthmd7gi 239 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 239 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 239 4 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 239 5 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 239 6 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 239 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 239 8 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 239 9 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 239 10 markers marker NNS work_zbi2knhp65ho5n7vbsuthmd7gi 239 11 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 239 12 LAMP1 LAMP1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 239 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 239 14 LC3-II LC3-II NNP work_zbi2knhp65ho5n7vbsuthmd7gi 239 15 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 239 16 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 239 17 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 239 18 substrates substrates NNP work_zbi2knhp65ho5n7vbsuthmd7gi 239 19 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 239 20 SQSTM1 SQSTM1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 239 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 239 22 SNCA SNCA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 239 23 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 239 24 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 239 25 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 240 1 2A 2A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 240 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 240 3 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 240 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 240 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 241 1 Concerning concern VBG work_zbi2knhp65ho5n7vbsuthmd7gi 241 2 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 241 3 mechanism mechanism NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 5 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 241 6 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 241 7 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 241 8 autophagic- autophagic- NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 9 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 241 10 alterations alteration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 241 11 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 241 12 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 13 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 241 14 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 15 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 241 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 241 17 our -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 241 18 data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 241 19 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 241 20 most most RBS work_zbi2knhp65ho5n7vbsuthmd7gi 241 21 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 241 22 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 23 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 241 24 functional functional JJ work_zbi2knhp65ho5n7vbsuthmd7gi 241 25 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 26 imposed impose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 241 27 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 28 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 241 29 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 30 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 241 31 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 32 level.49,73 level.49,73 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 241 33 Aminoquinoline Aminoquinoline NNP work_zbi2knhp65ho5n7vbsuthmd7gi 241 34 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 241 35 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 241 36 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 241 37 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 241 38 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 241 39 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 241 40 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 241 41 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 241 42 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 241 43 established establish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 241 44 lysosomotropic lysosomotropic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 241 45 agents agent NNS work_zbi2knhp65ho5n7vbsuthmd7gi 241 46 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 241 47 cause cause VBP work_zbi2knhp65ho5n7vbsuthmd7gi 241 48 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 241 49 disruption disruption NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 50 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 51 impairment impairment NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 52 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 53 pH pH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 241 54 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 55 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 241 56 inactivation inactivation NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 57 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 58 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 241 59 proteases protease NNS work_zbi2knhp65ho5n7vbsuthmd7gi 241 60 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 241 61 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 241 62 cathepsins cathepsin NNS work_zbi2knhp65ho5n7vbsuthmd7gi 241 63 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 241 64 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 241 65 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 241 66 mechanism mechanism NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 67 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 68 action action NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 69 underlying underlie VBG work_zbi2knhp65ho5n7vbsuthmd7gi 241 70 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 241 71 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 72 through through IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 73 disruption disruption NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 74 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 75 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 241 76 acidic acidic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 241 77 food food NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 78 vacuole vacuole NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 79 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 80 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 241 81 parasite.51 parasite.51 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 241 82 We -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 241 83 observed observe VBD work_zbi2knhp65ho5n7vbsuthmd7gi 241 84 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 241 85 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 241 86 cathepsin cathepsin NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 87 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 88 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 241 89 impaired impair VBN work_zbi2knhp65ho5n7vbsuthmd7gi 241 90 rapidly rapidly RB work_zbi2knhp65ho5n7vbsuthmd7gi 241 91 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 241 92 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 241 93 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 242 1 3B 3B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 242 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 242 3 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 242 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 242 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 242 6 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 242 7 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 242 8 similar similar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 242 9 pattern pattern NN work_zbi2knhp65ho5n7vbsuthmd7gi 242 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 242 11 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 242 12 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 242 13 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 242 14 imposed impose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 242 15 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 242 16 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 242 17 lysosomally lysosomally RB work_zbi2knhp65ho5n7vbsuthmd7gi 242 18 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 242 19 targeted target VBN work_zbi2knhp65ho5n7vbsuthmd7gi 242 20 agent agent NN work_zbi2knhp65ho5n7vbsuthmd7gi 242 21 BafA BafA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 242 22 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 242 23 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 242 24 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 242 25 evidenced evidence VBN work_zbi2knhp65ho5n7vbsuthmd7gi 242 26 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 242 27 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 242 28 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 242 29 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 242 30 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 242 31 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 242 32 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 242 33 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 242 34 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 242 35 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 243 1 2D 2D VBN work_zbi2knhp65ho5n7vbsuthmd7gi 243 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 243 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 244 1 Moreover moreover RB work_zbi2knhp65ho5n7vbsuthmd7gi 244 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 244 3 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 244 4 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 244 5 turn- turn- NN work_zbi2knhp65ho5n7vbsuthmd7gi 244 6 over over IN work_zbi2knhp65ho5n7vbsuthmd7gi 244 7 assay assay NNP work_zbi2knhp65ho5n7vbsuthmd7gi 244 8 employing employ VBG work_zbi2knhp65ho5n7vbsuthmd7gi 244 9 BafA BafA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 244 10 did do VBD work_zbi2knhp65ho5n7vbsuthmd7gi 244 11 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 244 12 indicate indicate VB work_zbi2knhp65ho5n7vbsuthmd7gi 244 13 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 244 14 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 244 15 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 244 16 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 244 17 flux flux NN work_zbi2knhp65ho5n7vbsuthmd7gi 244 18 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 244 19 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 244 20 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 244 21 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 244 22 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 244 23 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 244 24 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 245 1 3A 3A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 245 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 245 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 245 4 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 245 5 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 245 6 accumu- accumu- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 245 7 lation lation NN work_zbi2knhp65ho5n7vbsuthmd7gi 245 8 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 245 9 double double JJ work_zbi2knhp65ho5n7vbsuthmd7gi 245 10 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 245 11 membrane membrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 245 12 structures structure NNS work_zbi2knhp65ho5n7vbsuthmd7gi 245 13 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 245 14 would would MD work_zbi2knhp65ho5n7vbsuthmd7gi 245 15 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 245 16 indicative indicative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 245 17 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 245 18 increased increase VBN work_zbi2knhp65ho5n7vbsuthmd7gi 245 19 autophagosome autophagosome JJ work_zbi2knhp65ho5n7vbsuthmd7gi 245 20 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 245 21 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 245 22 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 245 23 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 245 24 electron electron NNP work_zbi2knhp65ho5n7vbsuthmd7gi 245 25 microscopy microscopy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 245 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 246 1 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 246 2 contrast contrast NN work_zbi2knhp65ho5n7vbsuthmd7gi 246 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 246 4 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 246 5 only only RB work_zbi2knhp65ho5n7vbsuthmd7gi 246 6 detected detect VBD work_zbi2knhp65ho5n7vbsuthmd7gi 246 7 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 246 8 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 246 9 large large JJ work_zbi2knhp65ho5n7vbsuthmd7gi 246 10 single single JJ work_zbi2knhp65ho5n7vbsuthmd7gi 246 11 membrane membrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 246 12 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 246 13 enclosed enclose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 246 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 246 15 multivesicular multivesicular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 246 16 structures structure NNS work_zbi2knhp65ho5n7vbsuthmd7gi 246 17 displaying display VBG work_zbi2knhp65ho5n7vbsuthmd7gi 246 18 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 246 19 osmiophilicity osmiophilicity NN work_zbi2knhp65ho5n7vbsuthmd7gi 246 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 246 21 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 246 22 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 246 23 autolysosomal autolysosomal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 246 24 aggre- aggre- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 246 25 gation gation NN work_zbi2knhp65ho5n7vbsuthmd7gi 246 26 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 246 27 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 246 28 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 246 29 undigested undigested JJ work_zbi2knhp65ho5n7vbsuthmd7gi 246 30 cargo cargo NN work_zbi2knhp65ho5n7vbsuthmd7gi 246 31 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 246 32 lipofuscin lipofuscin NNS work_zbi2knhp65ho5n7vbsuthmd7gi 246 33 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 246 34 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 246 35 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 246 36 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 246 37 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 247 1 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 247 2 addition addition NN work_zbi2knhp65ho5n7vbsuthmd7gi 247 3 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 247 4 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 247 5 causation causation NN work_zbi2knhp65ho5n7vbsuthmd7gi 247 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 247 7 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 247 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 247 9 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 247 10 altera- altera- NN work_zbi2knhp65ho5n7vbsuthmd7gi 247 11 tions tion NNS work_zbi2knhp65ho5n7vbsuthmd7gi 247 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 247 13 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 247 14 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 247 15 observed observe VBD work_zbi2knhp65ho5n7vbsuthmd7gi 247 16 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 247 17 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 247 18 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 247 19 blocked block VBD work_zbi2knhp65ho5n7vbsuthmd7gi 247 20 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 247 21 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 247 22 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 247 23 progression progression NN work_zbi2knhp65ho5n7vbsuthmd7gi 247 24 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 247 25 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 247 26 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 247 27 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 247 28 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 247 29 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 247 30 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 248 1 6D 6d NN work_zbi2knhp65ho5n7vbsuthmd7gi 248 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 248 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 249 1 It -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 249 2 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 249 3 important important JJ work_zbi2knhp65ho5n7vbsuthmd7gi 249 4 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 249 5 note note VB work_zbi2knhp65ho5n7vbsuthmd7gi 249 6 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 249 7 induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 249 8 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 249 9 mitotic mitotic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 249 10 arrest arrest NN work_zbi2knhp65ho5n7vbsuthmd7gi 249 11 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 249 12 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 249 13 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 249 14 lysosomotropic lysosomotropic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 249 15 agents agent NNS work_zbi2knhp65ho5n7vbsuthmd7gi 249 16 has have VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 249 17 been be VBN work_zbi2knhp65ho5n7vbsuthmd7gi 249 18 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 249 19 before before RB work_zbi2knhp65ho5n7vbsuthmd7gi 249 20 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 249 21 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 249 22 attributed attribute VBN work_zbi2knhp65ho5n7vbsuthmd7gi 249 23 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 249 24 impaired impaired JJ work_zbi2knhp65ho5n7vbsuthmd7gi 249 25 macroautophagy macroautophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 249 26 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 249 27 TP53-mediated tp53-mediate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 249 28 effects,51,74 effects,51,74 CD work_zbi2knhp65ho5n7vbsuthmd7gi 249 29 molecular molecular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 249 30 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 249 31 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 249 32 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 249 33 occur occur VBP work_zbi2knhp65ho5n7vbsuthmd7gi 249 34 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 249 35 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 249 36 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 249 37 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 249 38 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 249 39 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 249 40 Figs fig NNS work_zbi2knhp65ho5n7vbsuthmd7gi 249 41 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 250 1 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 250 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 250 3 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 250 4 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 250 5 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 250 6 6 6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 250 7 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 250 8 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 251 1 Our -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 251 2 own own JJ work_zbi2knhp65ho5n7vbsuthmd7gi 251 3 array array NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 4 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 5 revealed reveal VBD work_zbi2knhp65ho5n7vbsuthmd7gi 251 6 modulation modulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 251 8 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 9 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 10 antagonizing antagonize VBG work_zbi2knhp65ho5n7vbsuthmd7gi 251 11 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 12 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 13 progression progression NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 14 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 251 15 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 251 16 upreg- upreg- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 251 17 ulation ulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 251 19 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 251 20 downregulation downregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 251 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 251 23 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 251 24 immunoblot immunoblot NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 25 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 26 dem- dem- IN work_zbi2knhp65ho5n7vbsuthmd7gi 251 27 onstrated onstrated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 251 28 AQ aq NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 29 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 251 30 modulation modulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 251 31 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 251 32 TP53 TP53 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 251 33 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 251 34 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 251 35 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 251 36 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 251 37 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 251 38 CCND1 CCND1 '' work_zbi2knhp65ho5n7vbsuthmd7gi 251 39 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 251 40 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 251 41 phosphorylated phosphorylate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 251 42 RB1 RB1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 251 43 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 251 44 Ser780 ser780 CD work_zbi2knhp65ho5n7vbsuthmd7gi 251 45 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 251 46 807/811 807/811 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 251 47 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 251 48 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 252 1 Indeed indeed RB work_zbi2knhp65ho5n7vbsuthmd7gi 252 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 252 3 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 252 4 dis- dis- IN work_zbi2knhp65ho5n7vbsuthmd7gi 252 5 played play VBD work_zbi2knhp65ho5n7vbsuthmd7gi 252 6 potent potent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 252 7 antiproliferative antiproliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 252 8 effects effect NNS work_zbi2knhp65ho5n7vbsuthmd7gi 252 9 causing cause VBG work_zbi2knhp65ho5n7vbsuthmd7gi 252 10 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 252 11 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 252 12 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 252 13 arrest arrest NN work_zbi2knhp65ho5n7vbsuthmd7gi 252 14 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 252 15 submicromolar submicromolar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 252 16 concentrations concentration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 252 17 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 252 18 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 252 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 253 1 6D 6d NN work_zbi2knhp65ho5n7vbsuthmd7gi 253 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 253 3 E E NNP work_zbi2knhp65ho5n7vbsuthmd7gi 253 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 253 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 254 1 Downregulation Downregulation NNP work_zbi2knhp65ho5n7vbsuthmd7gi 254 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 254 3 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 254 4 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 254 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 254 6 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 254 7 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 254 8 displaying display VBG work_zbi2knhp65ho5n7vbsuthmd7gi 254 9 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 254 10 highest high JJS work_zbi2knhp65ho5n7vbsuthmd7gi 254 11 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 254 12 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 254 13 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 254 14 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 254 15 differential differential NN work_zbi2knhp65ho5n7vbsuthmd7gi 254 16 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 254 17 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 254 18 mRNA mrna JJ work_zbi2knhp65ho5n7vbsuthmd7gi 254 19 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 254 20 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 254 21 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 254 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 255 1 5 5 LS work_zbi2knhp65ho5n7vbsuthmd7gi 255 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 255 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 255 4 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 255 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 255 6 particu- particu- NN work_zbi2knhp65ho5n7vbsuthmd7gi 255 7 lar lar NN work_zbi2knhp65ho5n7vbsuthmd7gi 255 8 interest interest NN work_zbi2knhp65ho5n7vbsuthmd7gi 255 9 since since IN work_zbi2knhp65ho5n7vbsuthmd7gi 255 10 pharmacological pharmacological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 255 11 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 255 12 antagonism antagonism NN work_zbi2knhp65ho5n7vbsuthmd7gi 255 13 has have VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 255 14 recently recently RB work_zbi2knhp65ho5n7vbsuthmd7gi 255 15 emerged emerge VBN work_zbi2knhp65ho5n7vbsuthmd7gi 255 16 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 255 17 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 255 18 promising promising JJ work_zbi2knhp65ho5n7vbsuthmd7gi 255 19 antiproliferative antiproliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 255 20 strategy strategy NN work_zbi2knhp65ho5n7vbsuthmd7gi 255 21 targeting target VBG work_zbi2knhp65ho5n7vbsuthmd7gi 255 22 mela- mela- IN work_zbi2knhp65ho5n7vbsuthmd7gi 255 23 noma.67 noma.67 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 255 24 Indeed indeed RB work_zbi2knhp65ho5n7vbsuthmd7gi 255 25 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 255 26 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 255 27 observed observe VBD work_zbi2knhp65ho5n7vbsuthmd7gi 255 28 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 255 29 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 255 30 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 255 31 downregulation downregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 255 32 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 255 33 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 255 34 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 255 35 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 255 36 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 255 37 concentrations concentration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 255 38 as as RB work_zbi2knhp65ho5n7vbsuthmd7gi 255 39 low low JJ work_zbi2knhp65ho5n7vbsuthmd7gi 255 40 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 255 41 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 255 42 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 255 43 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 255 44 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 255 45 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 256 1 6A 6a NN work_zbi2knhp65ho5n7vbsuthmd7gi 256 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 256 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 257 1 However however RB work_zbi2knhp65ho5n7vbsuthmd7gi 257 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 257 3 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 257 4 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 257 5 mechanisms mechanism NNS work_zbi2knhp65ho5n7vbsuthmd7gi 257 6 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 257 7 upstream upstream JJ work_zbi2knhp65ho5n7vbsuthmd7gi 257 8 events event NNS work_zbi2knhp65ho5n7vbsuthmd7gi 257 9 underly- underly- VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 257 10 ing ing NNP work_zbi2knhp65ho5n7vbsuthmd7gi 257 11 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 257 12 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 257 13 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 257 14 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 257 15 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 257 16 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 257 17 shown show VBN work_zbi2knhp65ho5n7vbsuthmd7gi 257 18 here here RB work_zbi2knhp65ho5n7vbsuthmd7gi 257 19 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 257 20 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 257 21 first first JJ work_zbi2knhp65ho5n7vbsuthmd7gi 257 22 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 257 23 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 257 24 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 257 25 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 257 26 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 257 27 remain remain VBP work_zbi2knhp65ho5n7vbsuthmd7gi 257 28 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 257 29 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 257 30 elucidated elucidate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 257 31 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 258 1 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 258 2 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 258 3 context context NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 258 5 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 258 6 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 258 7 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 258 8 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 9 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 10 arrest arrest NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 11 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 258 12 occurs occur VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 258 13 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 258 14 S s NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 15 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 258 16 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 17 rather rather RB work_zbi2knhp65ho5n7vbsuthmd7gi 258 18 than than IN work_zbi2knhp65ho5n7vbsuthmd7gi 258 19 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 258 20 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 258 21 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 258 22 -phase -phase CD work_zbi2knhp65ho5n7vbsuthmd7gi 258 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 258 24 it -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 258 25 should should MD work_zbi2knhp65ho5n7vbsuthmd7gi 258 26 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 258 27 mentioned mention VBN work_zbi2knhp65ho5n7vbsuthmd7gi 258 28 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 258 29 earlier early JJR work_zbi2knhp65ho5n7vbsuthmd7gi 258 30 research research NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 31 has have VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 258 32 demonstrated demonstrate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 258 33 that that DT work_zbi2knhp65ho5n7vbsuthmd7gi 258 34 overexpression overexpression NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 35 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 258 36 pharmacologi- pharmacologi- NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 37 cal cal NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 38 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 39 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 258 40 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 258 41 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 42 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 258 43 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 258 44 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 45 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 46 regulator regulator NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 47 displaying display VBG work_zbi2knhp65ho5n7vbsuthmd7gi 258 48 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 258 49 most most RBS work_zbi2knhp65ho5n7vbsuthmd7gi 258 50 pronounced pronounced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 258 51 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 52 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 258 53 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 258 54 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 55 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 258 56 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 258 57 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 58 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 258 59 both both CC work_zbi2knhp65ho5n7vbsuthmd7gi 258 60 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 258 61 mRNA mrna NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 62 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 258 63 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 64 levels level NNS work_zbi2knhp65ho5n7vbsuthmd7gi 258 65 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 258 66 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 258 67 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 259 1 5B 5b JJ work_zbi2knhp65ho5n7vbsuthmd7gi 259 2 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 259 3 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 259 4 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 260 1 6A 6A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 260 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 260 3 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 260 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 260 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 260 6 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 260 7 indeed indeed RB work_zbi2knhp65ho5n7vbsuthmd7gi 260 8 cause cause VB work_zbi2knhp65ho5n7vbsuthmd7gi 260 9 S s NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 10 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 260 11 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 12 arrest,60,75,76 arrest,60,75,76 NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 13 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 260 14 phar- phar- VB work_zbi2knhp65ho5n7vbsuthmd7gi 260 15 macological macological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 260 16 downregulation downregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 17 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 260 18 CCND1 ccnd1 NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 19 as as RB work_zbi2knhp65ho5n7vbsuthmd7gi 260 20 well well RB work_zbi2knhp65ho5n7vbsuthmd7gi 260 21 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 260 22 dephosphory- dephosphory- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 260 23 lation lation NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 24 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 260 25 RB1 RB1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 260 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 260 27 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 260 28 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 260 29 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 260 30 us -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 260 31 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 260 32 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 33 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 260 34 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 260 35 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 36 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 260 37 have have VBP work_zbi2knhp65ho5n7vbsuthmd7gi 260 38 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 260 39 been be VBN work_zbi2knhp65ho5n7vbsuthmd7gi 260 40 documented document VBN work_zbi2knhp65ho5n7vbsuthmd7gi 260 41 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 260 42 association association NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 43 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 260 44 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 260 45 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 260 46 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 47 arrest.77,78 arrest.77,78 VB work_zbi2knhp65ho5n7vbsuthmd7gi 260 48 Our -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 260 49 experiments experiment NNS work_zbi2knhp65ho5n7vbsuthmd7gi 260 50 document document NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 51 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 260 52 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 260 53 first first JJ work_zbi2knhp65ho5n7vbsuthmd7gi 260 54 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 55 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 260 56 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 260 57 treat- treat- NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 58 ment ment NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 59 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 260 60 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 260 61 rapid rapid JJ work_zbi2knhp65ho5n7vbsuthmd7gi 260 62 induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 63 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 260 64 energy energy NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 65 crisis crisis NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 66 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 260 67 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 260 68 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 261 1 4B 4B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 261 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 261 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 261 4 impair- impair- VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 261 5 ment ment JJ work_zbi2knhp65ho5n7vbsuthmd7gi 261 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 261 7 mitochondrial mitochondrial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 261 8 transmembrane transmembrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 261 9 potential potential NN work_zbi2knhp65ho5n7vbsuthmd7gi 261 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 261 11 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 261 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 262 1 4C 4C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 262 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 262 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 262 4 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 262 5 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 262 6 blockade blockade NN work_zbi2knhp65ho5n7vbsuthmd7gi 262 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 262 8 starvation starvation NN work_zbi2knhp65ho5n7vbsuthmd7gi 262 9 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 262 10 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 262 11 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 262 12 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 262 13 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 262 14 adap- adap- NN work_zbi2knhp65ho5n7vbsuthmd7gi 262 15 tations tation NNS work_zbi2knhp65ho5n7vbsuthmd7gi 262 16 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 262 17 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 262 18 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 262 19 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 262 20 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 262 21 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 262 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 263 1 4A 4A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 263 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 263 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 264 1 This this DT work_zbi2knhp65ho5n7vbsuthmd7gi 264 2 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 3 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 264 4 sensitize sensitize VB work_zbi2knhp65ho5n7vbsuthmd7gi 264 5 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 6 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 264 7 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 264 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 264 9 cytotoxic cytotoxic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 264 10 metabolic metabolic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 264 11 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 12 imposed impose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 264 13 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 264 14 prolonged prolonged JJ work_zbi2knhp65ho5n7vbsuthmd7gi 264 15 starvation starvation NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 264 17 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 264 18 hypothesis hypothesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 19 substantiated substantiate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 264 20 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 264 21 our -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 264 22 observation observation NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 23 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 264 24 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 264 25 combined combine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 264 26 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 27 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 264 28 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 264 29 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 264 30 starva- starva- NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 31 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 32 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 264 33 culture culture NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 34 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 264 35 HBSS HBSS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 264 36 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 264 37 massive massive JJ work_zbi2knhp65ho5n7vbsuthmd7gi 264 38 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 39 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 40 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 264 41 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 264 42 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 264 43 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 265 1 4D 4d LS work_zbi2knhp65ho5n7vbsuthmd7gi 265 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 265 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 266 1 Likewise likewise RB work_zbi2knhp65ho5n7vbsuthmd7gi 266 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 266 3 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 266 4 observation observation NN work_zbi2knhp65ho5n7vbsuthmd7gi 266 5 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 266 6 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 266 7 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 266 8 chemosen- chemosen- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 266 9 sitization sitization NN work_zbi2knhp65ho5n7vbsuthmd7gi 266 10 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 266 11 standard standard JJ work_zbi2knhp65ho5n7vbsuthmd7gi 266 12 chemotherapeutic chemotherapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 266 13 agents agent NNS work_zbi2knhp65ho5n7vbsuthmd7gi 266 14 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 266 15 CDDP CDDP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 266 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 266 17 Doxo Doxo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 266 18 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 266 19 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 266 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 267 1 4E 4E NNP work_zbi2knhp65ho5n7vbsuthmd7gi 267 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 267 3 F F NNP work_zbi2knhp65ho5n7vbsuthmd7gi 267 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 267 5 suggests suggest VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 267 6 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 267 7 combination combination NN work_zbi2knhp65ho5n7vbsuthmd7gi 267 8 therapy therapy NN work_zbi2knhp65ho5n7vbsuthmd7gi 267 9 employing employ VBG work_zbi2knhp65ho5n7vbsuthmd7gi 267 10 chemotherapeutics chemotherapeutic NNS work_zbi2knhp65ho5n7vbsuthmd7gi 267 11 together together RB work_zbi2knhp65ho5n7vbsuthmd7gi 267 12 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 267 13 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 267 14 clinical clinical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 267 15 antimalarial antimalarial NN work_zbi2knhp65ho5n7vbsuthmd7gi 267 16 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 267 17 provide provide VB work_zbi2knhp65ho5n7vbsuthmd7gi 267 18 improved improve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 267 19 therapeutic therapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 267 20 efficacy efficacy NN work_zbi2knhp65ho5n7vbsuthmd7gi 267 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 267 22 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 267 23 hypothesis hypothesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 267 24 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 267 25 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 267 26 tested test VBN work_zbi2knhp65ho5n7vbsuthmd7gi 267 27 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 267 28 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 267 29 future future NN work_zbi2knhp65ho5n7vbsuthmd7gi 267 30 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 268 1 However however RB work_zbi2knhp65ho5n7vbsuthmd7gi 268 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 268 3 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 268 4 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 268 5 mechanism mechanism NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 6 underlying underlie VBG work_zbi2knhp65ho5n7vbsuthmd7gi 268 7 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 268 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 268 9 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 268 10 chemosensitization chemosensitization NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 11 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 268 12 increased increase VBN work_zbi2knhp65ho5n7vbsuthmd7gi 268 13 vulnerability vulnerability NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 14 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 15 starvation starvation NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 16 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 268 17 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 268 18 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 19 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 20 remains remain VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 268 21 undefined undefined JJ work_zbi2knhp65ho5n7vbsuthmd7gi 268 22 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 268 23 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 268 24 involve involve VB work_zbi2knhp65ho5n7vbsuthmd7gi 268 25 causative causative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 268 26 factors factor NNS work_zbi2knhp65ho5n7vbsuthmd7gi 268 27 beyond beyond IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 28 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 268 29 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 268 30 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 31 modu- modu- NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 32 lation lation NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 33 such such JJ work_zbi2knhp65ho5n7vbsuthmd7gi 268 34 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 35 impairment impairment NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 36 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 37 mitochondrial mitochondrial NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 38 transmembrane transmembrane NNP work_zbi2knhp65ho5n7vbsuthmd7gi 268 39 potential,58,79 potential,58,79 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 268 40 known know VBN work_zbi2knhp65ho5n7vbsuthmd7gi 268 41 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 268 42 occur occur VB work_zbi2knhp65ho5n7vbsuthmd7gi 268 43 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 44 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 45 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 46 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 47 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 48 other other JJ work_zbi2knhp65ho5n7vbsuthmd7gi 268 49 4-aminoquinoline 4-aminoquinoline CD work_zbi2knhp65ho5n7vbsuthmd7gi 268 50 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 268 51 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 268 52 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 268 53 here here RB work_zbi2knhp65ho5n7vbsuthmd7gi 268 54 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 55 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 268 56 first first JJ work_zbi2knhp65ho5n7vbsuthmd7gi 268 57 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 58 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 59 AQ.51,56 AQ.51,56 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 268 60 Interestingly interestingly RB work_zbi2knhp65ho5n7vbsuthmd7gi 268 61 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 268 62 it -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 268 63 has have VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 268 64 recently recently RB work_zbi2knhp65ho5n7vbsuthmd7gi 268 65 been be VBN work_zbi2knhp65ho5n7vbsuthmd7gi 268 66 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 268 67 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 68 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 268 69 sensitizes sensitize VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 268 70 breast breast NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 71 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 72 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 268 73 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 268 74 chemotherapy chemotherapy VB work_zbi2knhp65ho5n7vbsuthmd7gi 268 75 independent independent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 268 76 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 77 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 268 78 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 268 79 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 268 80 similar similar JJ work_zbi2knhp65ho5n7vbsuthmd7gi 268 81 mechanisms mechanism NNS work_zbi2knhp65ho5n7vbsuthmd7gi 268 82 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 268 83 apply apply VB work_zbi2knhp65ho5n7vbsuthmd7gi 268 84 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 85 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 268 86 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 268 87 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 268 88 sensitization.80 sensitization.80 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 268 89 Moreover moreover RB work_zbi2knhp65ho5n7vbsuthmd7gi 268 90 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 268 91 massive massive JJ work_zbi2knhp65ho5n7vbsuthmd7gi 268 92 downregulation downregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 93 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 94 heat heat NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 95 shock shock NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 96 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 97 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 98 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 99 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 100 observed observe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 268 101 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 102 us -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 268 103 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 268 104 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 268 105 mRNA mrna NN work_zbi2knhp65ho5n7vbsuthmd7gi 268 106 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 268 107 e.g. e.g. RB work_zbi2knhp65ho5n7vbsuthmd7gi 268 108 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 268 109 HSPA8 hspa8 UH work_zbi2knhp65ho5n7vbsuthmd7gi 268 110 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 268 111 HSPA1A hspa1a UH work_zbi2knhp65ho5n7vbsuthmd7gi 268 112 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 268 113 HSP90AA1 hsp90aa1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 268 114 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 268 115 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 268 116 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 269 1 5 5 LS work_zbi2knhp65ho5n7vbsuthmd7gi 269 2 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 269 3 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 269 4 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 270 1 6C 6c NN work_zbi2knhp65ho5n7vbsuthmd7gi 270 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 270 3 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 270 4 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 270 5 level level NN work_zbi2knhp65ho5n7vbsuthmd7gi 270 6 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 270 7 HSPA1A hspa1a UH work_zbi2knhp65ho5n7vbsuthmd7gi 270 8 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 270 9 HSP90AA1 hsp90aa1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 270 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 270 11 Fig Fig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 270 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 271 1 6A 6a NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 271 3 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 271 4 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 271 5 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 271 6 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 271 7 contrib- contrib- VB work_zbi2knhp65ho5n7vbsuthmd7gi 271 8 ute ute NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 9 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 271 10 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 271 11 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 271 12 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 271 13 sensitization sensitization NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 14 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 271 15 cytotoxic cytotoxic NNP work_zbi2knhp65ho5n7vbsuthmd7gi 271 16 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 271 18 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 271 19 hypothesis hypothesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 20 consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 271 21 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 271 22 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 271 23 established establish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 271 24 cytoprotective cytoprotective JJ work_zbi2knhp65ho5n7vbsuthmd7gi 271 25 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 271 26 antiapoptotic antiapoptotic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 271 27 role role NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 28 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 271 29 these these DT work_zbi2knhp65ho5n7vbsuthmd7gi 271 30 heat heat NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 31 shock shock NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 32 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 271 33 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 271 34 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 271 35 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 271 36 other other JJ work_zbi2knhp65ho5n7vbsuthmd7gi 271 37 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 38 cells.61,81,82 cells.61,81,82 NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 39 Currently currently RB work_zbi2knhp65ho5n7vbsuthmd7gi 271 40 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 271 41 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 271 42 molecular molecular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 271 43 basis basis NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 44 underlying underlie VBG work_zbi2knhp65ho5n7vbsuthmd7gi 271 45 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 271 46 more more RBR work_zbi2knhp65ho5n7vbsuthmd7gi 271 47 potent potent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 271 48 antimelanoma antimelanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 49 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 271 50 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 271 51 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 271 52 vs. vs. IN work_zbi2knhp65ho5n7vbsuthmd7gi 271 53 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 271 54 remains remain VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 271 55 undefined undefined JJ work_zbi2knhp65ho5n7vbsuthmd7gi 271 56 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 272 1 It -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 272 2 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 272 3 noteworthy noteworthy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 272 4 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 272 5 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 272 6 also also RB work_zbi2knhp65ho5n7vbsuthmd7gi 272 7 displays display VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 272 8 more more RBR work_zbi2knhp65ho5n7vbsuthmd7gi 272 9 potent potent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 272 10 antimalaria antimalaria NNP work_zbi2knhp65ho5n7vbsuthmd7gi 272 11 activ- activ- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 272 12 ity ity NNP work_zbi2knhp65ho5n7vbsuthmd7gi 272 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 272 14 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 272 15 property property NN work_zbi2knhp65ho5n7vbsuthmd7gi 272 16 attributed attribute VBN work_zbi2knhp65ho5n7vbsuthmd7gi 272 17 before before RB work_zbi2knhp65ho5n7vbsuthmd7gi 272 18 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 272 19 its -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 272 20 increased increase VBN work_zbi2knhp65ho5n7vbsuthmd7gi 272 21 tropism tropism NN work_zbi2knhp65ho5n7vbsuthmd7gi 272 22 targeting target VBG work_zbi2knhp65ho5n7vbsuthmd7gi 272 23 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 272 24 acidic acidic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 272 25 food food NN work_zbi2knhp65ho5n7vbsuthmd7gi 272 26 vacuole vacuole NN work_zbi2knhp65ho5n7vbsuthmd7gi 272 27 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 272 28 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 272 29 plasmodium plasmodium NN work_zbi2knhp65ho5n7vbsuthmd7gi 272 30 parasite,83 parasite,83 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 272 31 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 272 32 86 86 CD work_zbi2knhp65ho5n7vbsuthmd7gi 272 33 but but CC work_zbi2knhp65ho5n7vbsuthmd7gi 272 34 addi- addi- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 272 35 tional tional JJ work_zbi2knhp65ho5n7vbsuthmd7gi 272 36 structural structural JJ work_zbi2knhp65ho5n7vbsuthmd7gi 272 37 features feature NNS work_zbi2knhp65ho5n7vbsuthmd7gi 272 38 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 272 39 contribute contribute VB work_zbi2knhp65ho5n7vbsuthmd7gi 272 40 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 272 41 increased increase VBN work_zbi2knhp65ho5n7vbsuthmd7gi 272 42 potency potency NN work_zbi2knhp65ho5n7vbsuthmd7gi 272 43 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 272 44 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 272 45 drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 272 46 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 273 1 As as IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 2 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 3 its -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 273 4 parent parent NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 5 compound compound NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 6 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 273 8 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 9 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 273 10 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 273 11 lysoso- lysoso- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 12 motropic motropic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 13 4-aminoquinoline 4-aminoquinoline CD work_zbi2knhp65ho5n7vbsuthmd7gi 273 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 273 15 based base VBN work_zbi2knhp65ho5n7vbsuthmd7gi 273 16 tertiary tertiary JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 17 amine amine NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 273 19 but but CC work_zbi2knhp65ho5n7vbsuthmd7gi 273 20 only only RB work_zbi2knhp65ho5n7vbsuthmd7gi 273 21 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 22 contains contain VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 273 23 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 273 24 1,4-aminophenol 1,4-aminophenol CD work_zbi2knhp65ho5n7vbsuthmd7gi 273 25 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 273 26 substituent substituent NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 27 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 273 28 forms form VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 273 29 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 273 30 electro- electro- NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 31 philic philic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 32 quinoneimine quinoneimine JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 33 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 273 34 metabolite metabolite JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 35 upon upon IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 36 intracellular intracellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 37 oxidation oxidation NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 38 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 273 39 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 273 40 reactive reactive JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 41 intermediate intermediate NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 42 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 273 43 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 273 44 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 273 45 involved involve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 273 46 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 47 covalent covalent NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 48 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 49 adduction.47,48 adduction.47,48 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 50 Indeed indeed RB work_zbi2knhp65ho5n7vbsuthmd7gi 273 51 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 273 52 other other JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 53 drugs drug NNS work_zbi2knhp65ho5n7vbsuthmd7gi 273 54 containing contain VBG work_zbi2knhp65ho5n7vbsuthmd7gi 273 55 aminophenol- aminophenol- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 56 pharmacophores pharmacophore NNS work_zbi2knhp65ho5n7vbsuthmd7gi 273 57 cause cause VBP work_zbi2knhp65ho5n7vbsuthmd7gi 273 58 inhibitory inhibitory NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 59 adduction adduction NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 60 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 61 cysteine cysteine NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 62 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 273 63 residues residue NNS work_zbi2knhp65ho5n7vbsuthmd7gi 273 64 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 65 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 66 target target NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 67 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 273 68 such such JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 69 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 70 CTSB.87 CTSB.87 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 71 It -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 273 72 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 273 73 therefore therefore RB work_zbi2knhp65ho5n7vbsuthmd7gi 273 74 tempt- tempt- NNS work_zbi2knhp65ho5n7vbsuthmd7gi 273 75 ing e VBG work_zbi2knhp65ho5n7vbsuthmd7gi 273 76 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 273 77 speculate speculate VB work_zbi2knhp65ho5n7vbsuthmd7gi 273 78 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 79 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 80 addition addition NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 81 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 82 disruption disruption NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 83 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 84 lysosomal lysosomal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 85 pH pH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 86 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 87 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 273 88 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 273 89 physicochemical physicochemical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 90 effect effect NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 91 commonly commonly RB work_zbi2knhp65ho5n7vbsuthmd7gi 273 92 associated associate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 273 93 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 94 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 273 95 class class NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 96 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 97 4-aminoquinoline 4-aminoquinoline CD work_zbi2knhp65ho5n7vbsuthmd7gi 273 98 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 273 99 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 273 100 covalent covalent NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 101 adduction adduction NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 102 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 103 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 104 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 105 targets target NNS work_zbi2knhp65ho5n7vbsuthmd7gi 273 106 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 107 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 108 my -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 273 109 contribute contribute NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 110 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 111 its -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 273 112 higher high JJR work_zbi2knhp65ho5n7vbsuthmd7gi 273 113 © © NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 114 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 273 115 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 273 116 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 117 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 273 118 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 119 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 120 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 121 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 273 122 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 273 123 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 124 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 273 125 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 126 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 127 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 128 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 273 129 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 130 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 131 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 273 132 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 133 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 134 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 273 135 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 136 2098 2098 CD work_zbi2knhp65ho5n7vbsuthmd7gi 273 137 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 138 Volume Volume NNP work_zbi2knhp65ho5n7vbsuthmd7gi 273 139 9 9 CD work_zbi2knhp65ho5n7vbsuthmd7gi 273 140 issue issue NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 141 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 273 142 antimelanoma antimelanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 143 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 144 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 273 145 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 273 146 hypothesis hypothesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 147 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 273 148 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 273 149 tested test VBN work_zbi2knhp65ho5n7vbsuthmd7gi 273 150 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 273 151 future future JJ work_zbi2knhp65ho5n7vbsuthmd7gi 273 152 experi- experi- NN work_zbi2knhp65ho5n7vbsuthmd7gi 273 153 ments ment NNS work_zbi2knhp65ho5n7vbsuthmd7gi 273 154 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 274 1 Consistent consistent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 274 2 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 274 3 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 274 4 hypothesis hypothesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 274 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 274 6 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 274 7 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 274 8 monoclonal monoclonal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 274 9 anti- anti- NN work_zbi2knhp65ho5n7vbsuthmd7gi 274 10 body body NN work_zbi2knhp65ho5n7vbsuthmd7gi 274 11 employed employ VBN work_zbi2knhp65ho5n7vbsuthmd7gi 274 12 clinically clinically RB work_zbi2knhp65ho5n7vbsuthmd7gi 274 13 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 274 14 ELISA elisa NN work_zbi2knhp65ho5n7vbsuthmd7gi 274 15 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 274 16 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 274 17 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 274 18 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 274 19 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 274 20 adducted adduct VBN work_zbi2knhp65ho5n7vbsuthmd7gi 274 21 plasma plasma NN work_zbi2knhp65ho5n7vbsuthmd7gi 274 22 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 274 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 274 24 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 274 25 detected detect VBD work_zbi2knhp65ho5n7vbsuthmd7gi 274 26 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 274 27 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 274 28 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 274 29 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 274 30 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 274 31 modified modify VBN work_zbi2knhp65ho5n7vbsuthmd7gi 274 32 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 274 33 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 274 34 35- 35- CD work_zbi2knhp65ho5n7vbsuthmd7gi 274 35 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 274 36 55-kDa 55-kda CD work_zbi2knhp65ho5n7vbsuthmd7gi 274 37 molecular molecular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 274 38 mass mass NN work_zbi2knhp65ho5n7vbsuthmd7gi 274 39 range range NN work_zbi2knhp65ho5n7vbsuthmd7gi 274 40 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 274 41 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 274 42 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 274 43 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 274 44 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 274 45 Fig fig NN work_zbi2knhp65ho5n7vbsuthmd7gi 274 46 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 275 1 2A 2a LS work_zbi2knhp65ho5n7vbsuthmd7gi 275 2 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 275 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 276 1 Currently currently RB work_zbi2knhp65ho5n7vbsuthmd7gi 276 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 276 3 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 276 4 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 276 5 employing employ VBG work_zbi2knhp65ho5n7vbsuthmd7gi 276 6 proteomic proteomic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 276 7 tools tool NNS work_zbi2knhp65ho5n7vbsuthmd7gi 276 8 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 276 9 order order NN work_zbi2knhp65ho5n7vbsuthmd7gi 276 10 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 276 11 elucidate elucidate VB work_zbi2knhp65ho5n7vbsuthmd7gi 276 12 identity identity NN work_zbi2knhp65ho5n7vbsuthmd7gi 276 13 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 276 14 functional functional JJ work_zbi2knhp65ho5n7vbsuthmd7gi 276 15 implications implication NNS work_zbi2knhp65ho5n7vbsuthmd7gi 276 16 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 276 17 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 276 18 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 276 19 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 276 20 adducted adduct VBN work_zbi2knhp65ho5n7vbsuthmd7gi 276 21 target target NN work_zbi2knhp65ho5n7vbsuthmd7gi 276 22 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 276 23 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 276 24 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 276 25 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 276 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 277 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 277 2 concept concept NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 4 repurposing repurpose VBG work_zbi2knhp65ho5n7vbsuthmd7gi 277 5 clinical clinical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 6 antimalarials antimalarial NNS work_zbi2knhp65ho5n7vbsuthmd7gi 277 7 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 277 8 including include VBG work_zbi2knhp65ho5n7vbsuthmd7gi 277 9 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 277 11 hydroxychloroquine hydroxychloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 277 13 primaquine primaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 277 15 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 277 16 artemisinin artemisinin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 17 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 277 18 deriv- deriv- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 19 atives ative NNS work_zbi2knhp65ho5n7vbsuthmd7gi 277 20 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 277 21 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 22 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 23 chemotherapy chemotherapy NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 24 has have VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 277 25 recently recently RB work_zbi2knhp65ho5n7vbsuthmd7gi 277 26 gained gain VBN work_zbi2knhp65ho5n7vbsuthmd7gi 277 27 consider- consider- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 28 able able JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 29 attention.4,14,18 attention.4,14,18 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 30 - - : work_zbi2knhp65ho5n7vbsuthmd7gi 277 31 20,22,23,33,34 20,22,23,33,34 CD work_zbi2knhp65ho5n7vbsuthmd7gi 277 32 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 33 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 277 34 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 35 clinical clinical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 36 use use NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 37 worldwide worldwide RB work_zbi2knhp65ho5n7vbsuthmd7gi 277 38 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 277 39 yet yet RB work_zbi2knhp65ho5n7vbsuthmd7gi 277 40 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 277 41 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 42 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 277 43 United United NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 44 States States NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 45 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 277 46 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 47 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 277 48 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 49 equivalent equivalent NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 50 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 51 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 52 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 277 53 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 277 54 recent recent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 55 studies study NNS work_zbi2knhp65ho5n7vbsuthmd7gi 277 56 have have VBP work_zbi2knhp65ho5n7vbsuthmd7gi 277 57 shown show VBN work_zbi2knhp65ho5n7vbsuthmd7gi 277 58 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 59 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 60 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 277 61 superior superior JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 62 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 63 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 64 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 65 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 277 66 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 67 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 68 resistant resistant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 69 strains strain NNS work_zbi2knhp65ho5n7vbsuthmd7gi 277 70 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 71 Plasmodium Plasmodium NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 72 falciparum.83 falciparum.83 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 73 Remarkably remarkably RB work_zbi2knhp65ho5n7vbsuthmd7gi 277 74 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 277 75 safety safety NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 76 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 277 77 efficacy efficacy NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 78 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 79 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 80 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 277 81 based base VBN work_zbi2knhp65ho5n7vbsuthmd7gi 277 82 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 83 ther- ther- NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 84 apy apy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 85 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 277 86 well well RB work_zbi2knhp65ho5n7vbsuthmd7gi 277 87 established establish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 277 88 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 277 89 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 277 90 pharmacogenetic pharmacogenetic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 91 profiling profiling NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 92 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 93 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 277 94 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 95 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 277 96 metabolizing metabolize VBG work_zbi2knhp65ho5n7vbsuthmd7gi 277 97 enzyme enzyme NNS work_zbi2knhp65ho5n7vbsuthmd7gi 277 98 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 277 99 cytochrome cytochrome JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 100 P450 p450 NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 101 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 277 102 family family NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 103 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 277 104 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 277 105 subfam- subfam- CC work_zbi2knhp65ho5n7vbsuthmd7gi 277 106 ily ily NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 107 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 108 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 277 109 polypeptide polypeptide NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 110 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 277 111 ; ; , work_zbi2knhp65ho5n7vbsuthmd7gi 277 112 encoded encode VBN work_zbi2knhp65ho5n7vbsuthmd7gi 277 113 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 114 CYP2C8 CYP2C8 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 115 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 277 116 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 117 malaria malaria NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 118 patients patient NNS work_zbi2knhp65ho5n7vbsuthmd7gi 277 119 may may MD work_zbi2knhp65ho5n7vbsuthmd7gi 277 120 improve improve VB work_zbi2knhp65ho5n7vbsuthmd7gi 277 121 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 277 122 safe safe JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 123 use use NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 124 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 125 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 277 126 drug.88,89 drug.88,89 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 127 Taken Taken NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 128 together together RB work_zbi2knhp65ho5n7vbsuthmd7gi 277 129 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 277 130 our -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 277 131 data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 277 132 suggest suggest VBP work_zbi2knhp65ho5n7vbsuthmd7gi 277 133 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 134 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 277 135 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 277 136 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 277 137 promising promise VBG work_zbi2knhp65ho5n7vbsuthmd7gi 277 138 candidate candidate NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 139 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 140 drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 141 repurpos- repurpos- VBD work_zbi2knhp65ho5n7vbsuthmd7gi 277 142 ing e VBG work_zbi2knhp65ho5n7vbsuthmd7gi 277 143 efforts effort NNS work_zbi2knhp65ho5n7vbsuthmd7gi 277 144 aimed aim VBN work_zbi2knhp65ho5n7vbsuthmd7gi 277 145 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 146 undermining undermine VBG work_zbi2knhp65ho5n7vbsuthmd7gi 277 147 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 148 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 277 149 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 150 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 151 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 277 152 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 153 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 154 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 277 155 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 277 156 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 277 157 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 277 158 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 278 1 Our -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 278 2 cur- cur- NN work_zbi2knhp65ho5n7vbsuthmd7gi 278 3 rent rent NN work_zbi2knhp65ho5n7vbsuthmd7gi 278 4 research research NN work_zbi2knhp65ho5n7vbsuthmd7gi 278 5 efforts effort NNS work_zbi2knhp65ho5n7vbsuthmd7gi 278 6 aim aim VBP work_zbi2knhp65ho5n7vbsuthmd7gi 278 7 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 278 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 278 9 identification identification NN work_zbi2knhp65ho5n7vbsuthmd7gi 278 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 278 11 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 278 12 molecu- molecu- NN work_zbi2knhp65ho5n7vbsuthmd7gi 278 13 lar lar NN work_zbi2knhp65ho5n7vbsuthmd7gi 278 14 targets target NNS work_zbi2knhp65ho5n7vbsuthmd7gi 278 15 involved involve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 278 16 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 278 17 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 278 18 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 278 19 based base VBN work_zbi2knhp65ho5n7vbsuthmd7gi 278 20 inactivation inactivation NN work_zbi2knhp65ho5n7vbsuthmd7gi 278 21 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 278 22 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 278 23 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 278 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 278 25 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 278 26 studies study NNS work_zbi2knhp65ho5n7vbsuthmd7gi 278 27 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 278 28 aim aim VBP work_zbi2knhp65ho5n7vbsuthmd7gi 278 29 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 278 30 demonstrating demonstrate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 278 31 feasibility feasibility NN work_zbi2knhp65ho5n7vbsuthmd7gi 278 32 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 278 33 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 278 34 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 278 35 based base VBN work_zbi2knhp65ho5n7vbsuthmd7gi 278 36 adju- adju- NN work_zbi2knhp65ho5n7vbsuthmd7gi 278 37 vant vant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 278 38 chemotherapeutic chemotherapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 278 39 intervention intervention NN work_zbi2knhp65ho5n7vbsuthmd7gi 278 40 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 278 41 preclinical preclinical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 278 42 murine murine NN work_zbi2knhp65ho5n7vbsuthmd7gi 278 43 models model NNS work_zbi2knhp65ho5n7vbsuthmd7gi 278 44 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 278 45 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 278 46 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 278 47 have have VBP work_zbi2knhp65ho5n7vbsuthmd7gi 278 48 been be VBN work_zbi2knhp65ho5n7vbsuthmd7gi 278 49 initiated initiate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 278 50 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 279 1 Materials material NNS work_zbi2knhp65ho5n7vbsuthmd7gi 279 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 279 3 Methods method NNS work_zbi2knhp65ho5n7vbsuthmd7gi 279 4 Chemicals chemical NNS work_zbi2knhp65ho5n7vbsuthmd7gi 279 5 All all DT work_zbi2knhp65ho5n7vbsuthmd7gi 279 6 chemicals chemical NNS work_zbi2knhp65ho5n7vbsuthmd7gi 279 7 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 279 8 purchased purchase VBN work_zbi2knhp65ho5n7vbsuthmd7gi 279 9 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 279 10 Sigma Sigma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 279 11 Chemical Chemical NNP work_zbi2knhp65ho5n7vbsuthmd7gi 279 12 Co. Co. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 279 13 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 279 14 bafilomycin bafilomycin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 279 15 A1 A1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 279 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 279 17 B1793 b1793 NN work_zbi2knhp65ho5n7vbsuthmd7gi 279 18 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 279 19 chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 279 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 279 21 C6628 c6628 NN work_zbi2knhp65ho5n7vbsuthmd7gi 279 22 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 279 23 cis cis NN work_zbi2knhp65ho5n7vbsuthmd7gi 279 24 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 279 25 dichloro- dichloro- NN work_zbi2knhp65ho5n7vbsuthmd7gi 279 26 diamine diamine NN work_zbi2knhp65ho5n7vbsuthmd7gi 279 27 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 279 28 platinum platinum NN work_zbi2knhp65ho5n7vbsuthmd7gi 279 29 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 279 30 II II NNP work_zbi2knhp65ho5n7vbsuthmd7gi 279 31 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 279 32 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 279 33 P4394 P4394 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 279 34 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 279 35 doxorubicin doxorubicin NNS work_zbi2knhp65ho5n7vbsuthmd7gi 279 36 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 279 37 D1515 d1515 NN work_zbi2knhp65ho5n7vbsuthmd7gi 279 38 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 279 39 except except IN work_zbi2knhp65ho5n7vbsuthmd7gi 279 40 amo- amo- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 279 41 diaquine diaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 279 42 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 279 43 Fluka Fluka NNP work_zbi2knhp65ho5n7vbsuthmd7gi 279 44 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 279 45 A2799 A2799 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 279 46 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 279 47 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 280 1 Cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 280 2 culture culture NN work_zbi2knhp65ho5n7vbsuthmd7gi 280 3 Human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 280 4 malignant malignant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 280 5 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 280 6 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 280 7 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 280 8 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 280 9 ATCC ATCC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 280 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 280 11 CRL- CRL- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 280 12 1619 1619 CD work_zbi2knhp65ho5n7vbsuthmd7gi 280 13 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 280 14 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 280 15 cultured culture VBN work_zbi2knhp65ho5n7vbsuthmd7gi 280 16 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 280 17 RPMI RPMI NNP work_zbi2knhp65ho5n7vbsuthmd7gi 280 18 medium medium NN work_zbi2knhp65ho5n7vbsuthmd7gi 280 19 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 280 20 ATCC ATCC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 280 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 280 22 30 30 CD work_zbi2knhp65ho5n7vbsuthmd7gi 280 23 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 280 24 2001 2001 CD work_zbi2knhp65ho5n7vbsuthmd7gi 280 25 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 280 26 containing contain VBG work_zbi2knhp65ho5n7vbsuthmd7gi 280 27 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 280 28 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 280 29 bovine bovine JJ work_zbi2knhp65ho5n7vbsuthmd7gi 280 30 calf calf NN work_zbi2knhp65ho5n7vbsuthmd7gi 280 31 serum serum NN work_zbi2knhp65ho5n7vbsuthmd7gi 280 32 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 280 33 Hyclone Hyclone NNP work_zbi2knhp65ho5n7vbsuthmd7gi 280 34 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 280 35 SH30072.03 SH30072.03 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 280 36 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 280 37 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 281 1 LOX LOX NNP work_zbi2knhp65ho5n7vbsuthmd7gi 281 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 281 3 IMVI IMVI NNP work_zbi2knhp65ho5n7vbsuthmd7gi 281 4 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 281 5 metastatic metastatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 281 6 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 281 7 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 281 8 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 281 9 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 281 10 gift gift NN work_zbi2knhp65ho5n7vbsuthmd7gi 281 11 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 281 12 G. G. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 281 13 Paine Paine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 281 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 281 15 Murrieta Murrieta NNP work_zbi2knhp65ho5n7vbsuthmd7gi 281 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 281 17 University University NNP work_zbi2knhp65ho5n7vbsuthmd7gi 281 18 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 281 19 Arizona Arizona NNP work_zbi2knhp65ho5n7vbsuthmd7gi 281 20 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 281 21 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 281 22 cultured culture VBN work_zbi2knhp65ho5n7vbsuthmd7gi 281 23 exactly exactly RB work_zbi2knhp65ho5n7vbsuthmd7gi 281 24 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 281 25 A375 a375 CD work_zbi2knhp65ho5n7vbsuthmd7gi 281 26 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 281 27 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 281 28 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 281 29 G361 G361 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 281 30 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 281 31 ATCC ATCC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 281 32 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 281 33 CRL-1424 CRL-1424 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 281 34 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 281 35 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 281 36 metastatic metastatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 281 37 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 281 38 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 281 39 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 281 40 cultured culture VBN work_zbi2knhp65ho5n7vbsuthmd7gi 281 41 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 281 42 McCoy McCoy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 281 43 ’s ’s POS work_zbi2knhp65ho5n7vbsuthmd7gi 281 44 5a 5a CD work_zbi2knhp65ho5n7vbsuthmd7gi 281 45 medium medium NN work_zbi2knhp65ho5n7vbsuthmd7gi 281 46 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 281 47 ATCC ATCC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 281 48 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 281 49 30 30 CD work_zbi2knhp65ho5n7vbsuthmd7gi 281 50 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 281 51 2007 2007 CD work_zbi2knhp65ho5n7vbsuthmd7gi 281 52 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 281 53 containing contain VBG work_zbi2knhp65ho5n7vbsuthmd7gi 281 54 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 281 55 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 281 56 bovine bovine JJ work_zbi2knhp65ho5n7vbsuthmd7gi 281 57 calf calf NN work_zbi2knhp65ho5n7vbsuthmd7gi 281 58 serum serum NN work_zbi2knhp65ho5n7vbsuthmd7gi 281 59 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 282 1 Cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 282 2 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 282 3 main- main- RB work_zbi2knhp65ho5n7vbsuthmd7gi 282 4 tained taine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 282 5 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 282 6 37 37 CD work_zbi2knhp65ho5n7vbsuthmd7gi 282 7 ° ° NNS work_zbi2knhp65ho5n7vbsuthmd7gi 282 8 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 282 9 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 282 10 5 5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 282 11 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 282 12 CO CO NNP work_zbi2knhp65ho5n7vbsuthmd7gi 282 13 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 282 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 282 15 95 95 CD work_zbi2knhp65ho5n7vbsuthmd7gi 282 16 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 282 17 air air NN work_zbi2knhp65ho5n7vbsuthmd7gi 282 18 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 282 19 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 282 20 humidified humidified JJ work_zbi2knhp65ho5n7vbsuthmd7gi 282 21 incubator incubator NN work_zbi2knhp65ho5n7vbsuthmd7gi 282 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 283 1 Dulbecco Dulbecco NNP work_zbi2knhp65ho5n7vbsuthmd7gi 283 2 ’s ’s POS work_zbi2knhp65ho5n7vbsuthmd7gi 283 3 phosphate phosphate NN work_zbi2knhp65ho5n7vbsuthmd7gi 283 4 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 283 5 buffered buffer VBN work_zbi2knhp65ho5n7vbsuthmd7gi 283 6 saline saline NN work_zbi2knhp65ho5n7vbsuthmd7gi 283 7 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 283 8 PBS PBS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 283 9 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 283 10 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 283 11 HBSS HBSS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 283 12 contain- contain- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 283 13 ing e VBG work_zbi2knhp65ho5n7vbsuthmd7gi 283 14 5.6 5.6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 283 15 mM mm NN work_zbi2knhp65ho5n7vbsuthmd7gi 283 16 D d NN work_zbi2knhp65ho5n7vbsuthmd7gi 283 17 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 283 18 glucose glucose NN work_zbi2knhp65ho5n7vbsuthmd7gi 283 19 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 283 20 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 283 21 Life Life NNP work_zbi2knhp65ho5n7vbsuthmd7gi 283 22 Technologies Technologies NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 283 23 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 283 24 14199 14199 CD work_zbi2knhp65ho5n7vbsuthmd7gi 283 25 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 283 26 144 144 CD work_zbi2knhp65ho5n7vbsuthmd7gi 283 27 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 283 28 14025 14025 CD work_zbi2knhp65ho5n7vbsuthmd7gi 283 29 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 283 30 092 092 CD work_zbi2knhp65ho5n7vbsuthmd7gi 283 31 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 283 32 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 284 1 Transmission transmission NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 2 electron electron NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 3 microscopy microscopy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 284 4 Cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 284 5 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 284 6 fixed fix VBN work_zbi2knhp65ho5n7vbsuthmd7gi 284 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 284 8 situ situ NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 9 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 284 10 2.5 2.5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 284 11 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 12 glutaraldehyde glutaraldehyde NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 13 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 284 14 0.1 0.1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 284 15 M m CD work_zbi2knhp65ho5n7vbsuthmd7gi 284 16 cacodylate cacodylate NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 17 buffer buffer NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 18 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 284 19 pH pH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 284 20 7.4 7.4 CD work_zbi2knhp65ho5n7vbsuthmd7gi 284 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 284 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 284 23 post post JJ work_zbi2knhp65ho5n7vbsuthmd7gi 284 24 - - VBN work_zbi2knhp65ho5n7vbsuthmd7gi 284 25 fixed fix VBN work_zbi2knhp65ho5n7vbsuthmd7gi 284 26 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 284 27 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 284 28 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 29 osmium osmium NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 30 tetroxide tetroxide NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 31 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 284 32 cacodylate cacodylate NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 33 buffer buffer NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 34 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 284 35 washed wash VBD work_zbi2knhp65ho5n7vbsuthmd7gi 284 36 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 284 37 scraped scrape VBN work_zbi2knhp65ho5n7vbsuthmd7gi 284 38 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 284 39 pelleted pellete VBN work_zbi2knhp65ho5n7vbsuthmd7gi 284 40 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 284 41 described describe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 284 42 recently.7,33 recently.7,33 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 284 43 Cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 284 44 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 284 45 then then RB work_zbi2knhp65ho5n7vbsuthmd7gi 284 46 stained stain VBN work_zbi2knhp65ho5n7vbsuthmd7gi 284 47 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 284 48 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 284 49 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 50 aqueous aqueous JJ work_zbi2knhp65ho5n7vbsuthmd7gi 284 51 uranyl uranyl NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 52 ace- ace- NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 284 53 tate tate NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 54 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 284 55 dehydrated dehydrate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 284 56 through through IN work_zbi2knhp65ho5n7vbsuthmd7gi 284 57 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 284 58 graded grade VBN work_zbi2knhp65ho5n7vbsuthmd7gi 284 59 series series NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 60 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 284 61 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 284 62 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 284 63 70 70 CD work_zbi2knhp65ho5n7vbsuthmd7gi 284 64 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 284 65 90 90 CD work_zbi2knhp65ho5n7vbsuthmd7gi 284 66 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 284 67 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 284 68 100 100 CD work_zbi2knhp65ho5n7vbsuthmd7gi 284 69 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 70 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 284 71 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 284 72 ethanol ethanol NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 73 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 284 74 infiltrated infiltrate VBD work_zbi2knhp65ho5n7vbsuthmd7gi 284 75 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 284 76 Spurr Spurr NNP work_zbi2knhp65ho5n7vbsuthmd7gi 284 77 ’s ’s POS work_zbi2knhp65ho5n7vbsuthmd7gi 284 78 resin resin NN work_zbi2knhp65ho5n7vbsuthmd7gi 284 79 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 284 80 Sigma Sigma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 284 81 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 284 82 EM0300 EM0300 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 284 83 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 284 84 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 284 85 then then RB work_zbi2knhp65ho5n7vbsuthmd7gi 284 86 allowed allow VBN work_zbi2knhp65ho5n7vbsuthmd7gi 284 87 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 284 88 polymerize polymerize VB work_zbi2knhp65ho5n7vbsuthmd7gi 284 89 overnight overnight RB work_zbi2knhp65ho5n7vbsuthmd7gi 284 90 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 284 91 60 60 CD work_zbi2knhp65ho5n7vbsuthmd7gi 284 92 ° ° NNS work_zbi2knhp65ho5n7vbsuthmd7gi 284 93 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 284 94 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 285 1 Sections section NNS work_zbi2knhp65ho5n7vbsuthmd7gi 285 2 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 285 3 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 285 4 nm nm CD work_zbi2knhp65ho5n7vbsuthmd7gi 285 5 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 285 6 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 285 7 cut cut VBN work_zbi2knhp65ho5n7vbsuthmd7gi 285 8 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 285 9 mounted mount VBN work_zbi2knhp65ho5n7vbsuthmd7gi 285 10 onto onto IN work_zbi2knhp65ho5n7vbsuthmd7gi 285 11 uncoated uncoated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 285 12 150-mesh 150-mesh CD work_zbi2knhp65ho5n7vbsuthmd7gi 285 13 copper copper NN work_zbi2knhp65ho5n7vbsuthmd7gi 285 14 grids grid NNS work_zbi2knhp65ho5n7vbsuthmd7gi 285 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 285 16 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 285 17 stained stain VBN work_zbi2knhp65ho5n7vbsuthmd7gi 285 18 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 285 19 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 285 20 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 285 21 lead lead NN work_zbi2knhp65ho5n7vbsuthmd7gi 285 22 citrate citrate NN work_zbi2knhp65ho5n7vbsuthmd7gi 285 23 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 286 1 Sections section NNS work_zbi2knhp65ho5n7vbsuthmd7gi 286 2 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 286 3 examined examine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 286 4 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 286 5 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 286 6 CM12 CM12 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 286 7 transmission transmission NN work_zbi2knhp65ho5n7vbsuthmd7gi 286 8 electron electron NN work_zbi2knhp65ho5n7vbsuthmd7gi 286 9 microscope microscope NN work_zbi2knhp65ho5n7vbsuthmd7gi 286 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 286 11 FEI FEI NNP work_zbi2knhp65ho5n7vbsuthmd7gi 286 12 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 286 13 operated operate VBD work_zbi2knhp65ho5n7vbsuthmd7gi 286 14 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 286 15 80 80 CD work_zbi2knhp65ho5n7vbsuthmd7gi 286 16 kV kV NNP work_zbi2knhp65ho5n7vbsuthmd7gi 286 17 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 286 18 digital digital JJ work_zbi2knhp65ho5n7vbsuthmd7gi 286 19 image image NN work_zbi2knhp65ho5n7vbsuthmd7gi 286 20 collection collection NN work_zbi2knhp65ho5n7vbsuthmd7gi 286 21 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 287 1 Flow flow VB work_zbi2knhp65ho5n7vbsuthmd7gi 287 2 cytometric cytometric JJ work_zbi2knhp65ho5n7vbsuthmd7gi 287 3 quantification quantification NN work_zbi2knhp65ho5n7vbsuthmd7gi 287 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 287 5 cellular cellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 287 6 autofluorescence autofluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 287 7 After after IN work_zbi2knhp65ho5n7vbsuthmd7gi 287 8 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 9 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 287 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 287 11 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 287 12 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 287 13 harvested harvest VBN work_zbi2knhp65ho5n7vbsuthmd7gi 287 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 287 15 washed wash VBN work_zbi2knhp65ho5n7vbsuthmd7gi 287 16 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 287 17 resus- resus- NN work_zbi2knhp65ho5n7vbsuthmd7gi 287 18 pended pende VBN work_zbi2knhp65ho5n7vbsuthmd7gi 287 19 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 287 20 300 300 CD work_zbi2knhp65ho5n7vbsuthmd7gi 287 21 μl μl NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 22 PBS PBS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 287 24 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 287 25 immediately immediately RB work_zbi2knhp65ho5n7vbsuthmd7gi 287 26 analyzed analyze VBN work_zbi2knhp65ho5n7vbsuthmd7gi 287 27 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 287 28 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 287 29 cytom- cytom- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 30 etry etry NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 31 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 287 32 λ λ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 33 ex ex NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 34 488 488 CD work_zbi2knhp65ho5n7vbsuthmd7gi 287 35 nm nm NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 36 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 287 37 λ λ UH work_zbi2knhp65ho5n7vbsuthmd7gi 287 38 em -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 287 39 585 585 CD work_zbi2knhp65ho5n7vbsuthmd7gi 287 40 ± ± CD work_zbi2knhp65ho5n7vbsuthmd7gi 287 41 42 42 CD work_zbi2knhp65ho5n7vbsuthmd7gi 287 42 nm nm IN work_zbi2knhp65ho5n7vbsuthmd7gi 287 43 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 287 44 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 287 45 published publish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 287 46 recently.38 recently.38 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 47 RFP RFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 48 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 287 49 GFP GFP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 50 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 287 51 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 52 puncta puncta NN work_zbi2knhp65ho5n7vbsuthmd7gi 287 53 formation formation NN work_zbi2knhp65ho5n7vbsuthmd7gi 287 54 assay assay NN work_zbi2knhp65ho5n7vbsuthmd7gi 287 55 A375 A375 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 56 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 287 57 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 287 58 grown grow VBN work_zbi2knhp65ho5n7vbsuthmd7gi 287 59 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 287 60 35-mm 35-mm NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 61 glass glass NN work_zbi2knhp65ho5n7vbsuthmd7gi 287 62 bottom bottom JJ work_zbi2knhp65ho5n7vbsuthmd7gi 287 63 dishes dish NNS work_zbi2knhp65ho5n7vbsuthmd7gi 287 64 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 287 65 MatTek MatTek NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 66 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 287 67 P35G-0 P35G-0 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 68 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 287 69 10-C 10-C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 287 70 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 287 71 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 287 72 live live JJ work_zbi2knhp65ho5n7vbsuthmd7gi 287 73 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 287 74 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 287 75 imaging imaging NN work_zbi2knhp65ho5n7vbsuthmd7gi 287 76 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 288 1 Cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 288 2 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 288 3 transfected transfecte VBN work_zbi2knhp65ho5n7vbsuthmd7gi 288 4 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 288 5 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 288 6 mRFP mrfp NN work_zbi2knhp65ho5n7vbsuthmd7gi 288 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 288 8 EGFP egfp NN work_zbi2knhp65ho5n7vbsuthmd7gi 288 9 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 288 10 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 288 11 construct construct NN work_zbi2knhp65ho5n7vbsuthmd7gi 288 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 288 13 Addgene Addgene NNP work_zbi2knhp65ho5n7vbsuthmd7gi 288 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 288 15 21074 21074 CD work_zbi2knhp65ho5n7vbsuthmd7gi 288 16 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 288 17 ptf ptf NN work_zbi2knhp65ho5n7vbsuthmd7gi 288 18 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 288 19 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 288 20 fol- fol- NN work_zbi2knhp65ho5n7vbsuthmd7gi 288 21 lowing low VBG work_zbi2knhp65ho5n7vbsuthmd7gi 288 22 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 288 23 published publish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 288 24 procedure.6 procedure.6 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 288 25 Twenty twenty CD work_zbi2knhp65ho5n7vbsuthmd7gi 288 26 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 288 27 four four CD work_zbi2knhp65ho5n7vbsuthmd7gi 288 28 hours hour NNS work_zbi2knhp65ho5n7vbsuthmd7gi 288 29 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 288 30 transfec- transfec- NN work_zbi2knhp65ho5n7vbsuthmd7gi 288 31 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 288 32 followed follow VBN work_zbi2knhp65ho5n7vbsuthmd7gi 288 33 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 288 34 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 288 35 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 288 36 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 288 37 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 288 38 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 288 39 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 288 40 up up IN work_zbi2knhp65ho5n7vbsuthmd7gi 288 41 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 288 42 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 288 43 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 288 44 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 288 45 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 288 46 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 288 47 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 288 48 gently gently RB work_zbi2knhp65ho5n7vbsuthmd7gi 288 49 washed wash VBN work_zbi2knhp65ho5n7vbsuthmd7gi 288 50 once once RB work_zbi2knhp65ho5n7vbsuthmd7gi 288 51 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 288 52 PBS PBS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 288 53 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 288 54 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 288 55 phenol phenol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 288 56 red red JJ work_zbi2knhp65ho5n7vbsuthmd7gi 288 57 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 288 58 free free JJ work_zbi2knhp65ho5n7vbsuthmd7gi 288 59 DMEM DMEM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 288 60 sup- sup- NN work_zbi2knhp65ho5n7vbsuthmd7gi 288 61 plemented plemente VBD work_zbi2knhp65ho5n7vbsuthmd7gi 288 62 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 288 63 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 288 64 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 288 65 FBS FBS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 288 66 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 288 67 added add VBN work_zbi2knhp65ho5n7vbsuthmd7gi 288 68 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 289 1 All all DT work_zbi2knhp65ho5n7vbsuthmd7gi 289 2 images image NNS work_zbi2knhp65ho5n7vbsuthmd7gi 289 3 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 289 4 taken take VBN work_zbi2knhp65ho5n7vbsuthmd7gi 289 5 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 289 6 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 289 7 Zeiss Zeiss NNP work_zbi2knhp65ho5n7vbsuthmd7gi 289 8 Observer Observer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 289 9 Z1 z1 NN work_zbi2knhp65ho5n7vbsuthmd7gi 289 10 microscope microscope NN work_zbi2knhp65ho5n7vbsuthmd7gi 289 11 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 289 12 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 289 13 Slidebook Slidebook NNP work_zbi2knhp65ho5n7vbsuthmd7gi 289 14 4.2.0.11 4.2.0.11 CD work_zbi2knhp65ho5n7vbsuthmd7gi 289 15 computer computer NN work_zbi2knhp65ho5n7vbsuthmd7gi 289 16 program program NN work_zbi2knhp65ho5n7vbsuthmd7gi 289 17 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 289 18 Intelligent Intelligent NNP work_zbi2knhp65ho5n7vbsuthmd7gi 289 19 Imaging Imaging NNP work_zbi2knhp65ho5n7vbsuthmd7gi 289 20 Innovations Innovations NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 289 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 289 22 Inc. Inc. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 289 23 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 289 24 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 290 1 Cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 290 2 proliferation proliferation NN work_zbi2knhp65ho5n7vbsuthmd7gi 290 3 assay assay NN work_zbi2knhp65ho5n7vbsuthmd7gi 290 4 Cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 290 5 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 290 6 seeded seed VBN work_zbi2knhp65ho5n7vbsuthmd7gi 290 7 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 290 8 5,000 5,000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 290 9 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 290 10 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 290 11 dish dish NN work_zbi2knhp65ho5n7vbsuthmd7gi 290 12 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 290 13 35-mm 35-mm NNP work_zbi2knhp65ho5n7vbsuthmd7gi 290 14 dishes dish NNS work_zbi2knhp65ho5n7vbsuthmd7gi 290 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 291 1 After after IN work_zbi2knhp65ho5n7vbsuthmd7gi 291 2 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 291 3 h h NNS work_zbi2knhp65ho5n7vbsuthmd7gi 291 4 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 291 5 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 291 6 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 291 7 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 291 8 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 291 9 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 291 10 test test NN work_zbi2knhp65ho5n7vbsuthmd7gi 291 11 compound compound NN work_zbi2knhp65ho5n7vbsuthmd7gi 291 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 291 13 CQ CQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 291 14 vs. vs. IN work_zbi2knhp65ho5n7vbsuthmd7gi 291 15 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 291 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 291 17 0.1–10 0.1–10 NFP work_zbi2knhp65ho5n7vbsuthmd7gi 291 18 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 291 19 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 291 20 72 72 CD work_zbi2knhp65ho5n7vbsuthmd7gi 291 21 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 291 22 continuous continuous JJ work_zbi2knhp65ho5n7vbsuthmd7gi 291 23 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 291 24 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 291 25 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 292 1 Numbers number NNS work_zbi2knhp65ho5n7vbsuthmd7gi 292 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 292 3 adherent adherent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 292 4 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 292 5 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 292 6 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 292 7 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 292 8 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 292 9 compound compound NN work_zbi2knhp65ho5n7vbsuthmd7gi 292 10 addition addition NN work_zbi2knhp65ho5n7vbsuthmd7gi 292 11 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 292 12 72 72 CD work_zbi2knhp65ho5n7vbsuthmd7gi 292 13 h h NNS work_zbi2knhp65ho5n7vbsuthmd7gi 292 14 later later RB work_zbi2knhp65ho5n7vbsuthmd7gi 292 15 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 292 16 determined determine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 292 17 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 292 18 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 292 19 Z2 z2 NN work_zbi2knhp65ho5n7vbsuthmd7gi 292 20 analyzer analyzer NN work_zbi2knhp65ho5n7vbsuthmd7gi 292 21 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 292 22 Beckman Beckman NNP work_zbi2knhp65ho5n7vbsuthmd7gi 292 23 Coulter Coulter NNP work_zbi2knhp65ho5n7vbsuthmd7gi 292 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 292 25 Inc. Inc. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 292 26 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 292 27 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 293 1 Proliferation Proliferation NNP work_zbi2knhp65ho5n7vbsuthmd7gi 293 2 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 293 3 compared compare VBN work_zbi2knhp65ho5n7vbsuthmd7gi 293 4 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 293 5 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 293 6 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 293 7 received receive VBD work_zbi2knhp65ho5n7vbsuthmd7gi 293 8 mock mock JJ work_zbi2knhp65ho5n7vbsuthmd7gi 293 9 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 293 10 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 294 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 294 2 same same JJ work_zbi2knhp65ho5n7vbsuthmd7gi 294 3 methodology methodology NN work_zbi2knhp65ho5n7vbsuthmd7gi 294 4 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 294 5 used use VBN work_zbi2knhp65ho5n7vbsuthmd7gi 294 6 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 294 7 establish establish VB work_zbi2knhp65ho5n7vbsuthmd7gi 294 8 IC IC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 294 9 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 294 10 values value NNS work_zbi2knhp65ho5n7vbsuthmd7gi 294 11 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 294 12 drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 294 13 concen- concen- NN work_zbi2knhp65ho5n7vbsuthmd7gi 294 14 tration tration NN work_zbi2knhp65ho5n7vbsuthmd7gi 294 15 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 294 16 induces induce VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 294 17 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 294 18 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 294 19 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 294 20 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 294 21 proliferation proliferation NN work_zbi2knhp65ho5n7vbsuthmd7gi 294 22 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 294 23 indicating indicate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 294 24 antiproliferative antiproliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 294 25 potency potency NN work_zbi2knhp65ho5n7vbsuthmd7gi 294 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 295 1 Flow flow VB work_zbi2knhp65ho5n7vbsuthmd7gi 295 2 cytometric cytometric JJ work_zbi2knhp65ho5n7vbsuthmd7gi 295 3 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 295 5 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 6 viability viability NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 7 Viability Viability NNP work_zbi2knhp65ho5n7vbsuthmd7gi 295 8 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 295 9 induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 295 11 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 12 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 13 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 295 14 early early RB work_zbi2knhp65ho5n7vbsuthmd7gi 295 15 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 295 16 late late JJ work_zbi2knhp65ho5n7vbsuthmd7gi 295 17 apop- apop- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 295 18 tosis tosis NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 19 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 295 20 necrosis necrosis NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 295 22 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 295 23 examined examine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 295 24 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 295 25 ANX ANX NNP work_zbi2knhp65ho5n7vbsuthmd7gi 295 26 A5 A5 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 295 27 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 295 28 annexin annexin NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 29 AV AV NNP work_zbi2knhp65ho5n7vbsuthmd7gi 295 30 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 295 31 FITC/ FITC/ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 295 32 propidium propidium NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 33 iodide iodide NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 34 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 295 35 PI pi NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 36 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 295 37 dual dual JJ work_zbi2knhp65ho5n7vbsuthmd7gi 295 38 staining staining NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 39 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 295 40 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 295 41 followed follow VBN work_zbi2knhp65ho5n7vbsuthmd7gi 295 42 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 295 43 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 44 cytometric cytometric NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 45 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 46 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 295 47 published publish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 295 48 previously.33,64 previously.33,64 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 295 49 Cells Cells NNP work_zbi2knhp65ho5n7vbsuthmd7gi 295 50 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 295 51 100,000 100,000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 295 52 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 295 53 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 295 54 seeded seed VBN work_zbi2knhp65ho5n7vbsuthmd7gi 295 55 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 295 56 35-mm 35-mm CD work_zbi2knhp65ho5n7vbsuthmd7gi 295 57 dishes dish NNS work_zbi2knhp65ho5n7vbsuthmd7gi 295 58 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 295 59 received receive VBD work_zbi2knhp65ho5n7vbsuthmd7gi 295 60 drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 61 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 295 62 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 295 63 h h NNS work_zbi2knhp65ho5n7vbsuthmd7gi 295 64 later later RB work_zbi2knhp65ho5n7vbsuthmd7gi 295 65 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 296 1 Cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 296 2 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 296 3 harvested harvest VBN work_zbi2knhp65ho5n7vbsuthmd7gi 296 4 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 296 5 various various JJ work_zbi2knhp65ho5n7vbsuthmd7gi 296 6 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 296 7 points point NNS work_zbi2knhp65ho5n7vbsuthmd7gi 296 8 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 296 9 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 296 10 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 296 11 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 296 12 staining staining NN work_zbi2knhp65ho5n7vbsuthmd7gi 296 13 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 296 14 performed perform VBN work_zbi2knhp65ho5n7vbsuthmd7gi 296 15 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 296 16 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 296 17 apoptosis apoptosis NN work_zbi2knhp65ho5n7vbsuthmd7gi 296 18 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 296 19 kit kit NN work_zbi2knhp65ho5n7vbsuthmd7gi 296 20 according accord VBG work_zbi2knhp65ho5n7vbsuthmd7gi 296 21 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 296 22 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 296 23 manufacturer manufacturer NN work_zbi2knhp65ho5n7vbsuthmd7gi 296 24 ’s ’s POS work_zbi2knhp65ho5n7vbsuthmd7gi 296 25 specifications specification NNS work_zbi2knhp65ho5n7vbsuthmd7gi 296 26 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 296 27 Sigma Sigma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 296 28 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 296 29 APOAF- APOAF- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 296 30 20TST 20tst CD work_zbi2knhp65ho5n7vbsuthmd7gi 296 31 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 296 32 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 297 1 Viable viable JJ work_zbi2knhp65ho5n7vbsuthmd7gi 297 2 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 297 3 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 297 4 located locate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 297 5 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 297 6 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 297 7 bottom bottom NN work_zbi2knhp65ho5n7vbsuthmd7gi 297 8 left leave VBD work_zbi2knhp65ho5n7vbsuthmd7gi 297 9 quadrant quadrant NN work_zbi2knhp65ho5n7vbsuthmd7gi 297 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 297 11 ANX ANX NNP work_zbi2knhp65ho5n7vbsuthmd7gi 297 12 A5− A5− NNP work_zbi2knhp65ho5n7vbsuthmd7gi 297 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 297 14 PI− PI− NNP work_zbi2knhp65ho5n7vbsuthmd7gi 297 15 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 297 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 297 17 whereas whereas IN work_zbi2knhp65ho5n7vbsuthmd7gi 297 18 early early JJ work_zbi2knhp65ho5n7vbsuthmd7gi 297 19 apoptotic apoptotic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 297 20 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 297 21 late late JJ work_zbi2knhp65ho5n7vbsuthmd7gi 297 22 apoptotic/ apoptotic/ NN work_zbi2knhp65ho5n7vbsuthmd7gi 297 23 necrotic necrotic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 297 24 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 297 25 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 297 26 located locate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 297 27 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 297 28 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 297 29 bottom bottom NN work_zbi2knhp65ho5n7vbsuthmd7gi 297 30 right right JJ work_zbi2knhp65ho5n7vbsuthmd7gi 297 31 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 297 32 ANX ANX NNP work_zbi2knhp65ho5n7vbsuthmd7gi 297 33 A5 A5 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 297 34 + + NNS work_zbi2knhp65ho5n7vbsuthmd7gi 297 35 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 297 36 PI− PI− NNP work_zbi2knhp65ho5n7vbsuthmd7gi 297 37 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 297 38 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 297 39 top top JJ work_zbi2knhp65ho5n7vbsuthmd7gi 297 40 right right JJ work_zbi2knhp65ho5n7vbsuthmd7gi 297 41 quadrant quadrant NN work_zbi2knhp65ho5n7vbsuthmd7gi 297 42 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 297 43 ANX ANX NNP work_zbi2knhp65ho5n7vbsuthmd7gi 297 44 A5 a5 NN work_zbi2knhp65ho5n7vbsuthmd7gi 297 45 + + NNS work_zbi2knhp65ho5n7vbsuthmd7gi 297 46 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 297 47 PI+ pi+ NN work_zbi2knhp65ho5n7vbsuthmd7gi 297 48 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 297 49 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 297 50 respectively respectively RB work_zbi2knhp65ho5n7vbsuthmd7gi 297 51 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 298 1 Cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 298 2 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 298 3 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 298 4 Cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 298 5 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 298 6 seeded seed VBN work_zbi2knhp65ho5n7vbsuthmd7gi 298 7 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 298 8 25,000 25,000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 298 9 per per IN work_zbi2knhp65ho5n7vbsuthmd7gi 298 10 35-mm 35-mm CD work_zbi2knhp65ho5n7vbsuthmd7gi 298 11 dish dish NN work_zbi2knhp65ho5n7vbsuthmd7gi 298 12 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 298 13 left leave VBD work_zbi2knhp65ho5n7vbsuthmd7gi 298 14 over- over- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 298 15 night night NN work_zbi2knhp65ho5n7vbsuthmd7gi 298 16 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 298 17 attach attach VB work_zbi2knhp65ho5n7vbsuthmd7gi 298 18 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 299 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 299 2 next next JJ work_zbi2knhp65ho5n7vbsuthmd7gi 299 3 day day NN work_zbi2knhp65ho5n7vbsuthmd7gi 299 4 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 299 5 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 299 6 received receive VBD work_zbi2knhp65ho5n7vbsuthmd7gi 299 7 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 299 8 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 299 9 test test NN work_zbi2knhp65ho5n7vbsuthmd7gi 299 10 compounds compound NNS work_zbi2knhp65ho5n7vbsuthmd7gi 299 11 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 299 12 vehicle vehicle NN work_zbi2knhp65ho5n7vbsuthmd7gi 299 13 controls control NNS work_zbi2knhp65ho5n7vbsuthmd7gi 299 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 300 1 After after IN work_zbi2knhp65ho5n7vbsuthmd7gi 300 2 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 300 3 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 300 4 48 48 CD work_zbi2knhp65ho5n7vbsuthmd7gi 300 5 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 300 6 continu- continu- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 300 7 ous ous JJ work_zbi2knhp65ho5n7vbsuthmd7gi 300 8 drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 300 9 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 300 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 300 11 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 300 12 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 300 13 processed process VBN work_zbi2knhp65ho5n7vbsuthmd7gi 300 14 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 300 15 published publish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 300 16 before.65 before.65 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 300 17 Cellular Cellular NNP work_zbi2knhp65ho5n7vbsuthmd7gi 300 18 DNA DNA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 300 19 content content NN work_zbi2knhp65ho5n7vbsuthmd7gi 300 20 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 300 21 determined determine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 300 22 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 300 23 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 300 24 cytometry cytometry NN work_zbi2knhp65ho5n7vbsuthmd7gi 300 25 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 300 26 analyzed analyze VBD work_zbi2knhp65ho5n7vbsuthmd7gi 300 27 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 300 28 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 300 29 ModFitLT ModFitLT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 300 30 software software NN work_zbi2knhp65ho5n7vbsuthmd7gi 300 31 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 300 32 version version NN work_zbi2knhp65ho5n7vbsuthmd7gi 300 33 4.0 4.0 CD work_zbi2knhp65ho5n7vbsuthmd7gi 300 34 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 300 35 Verity Verity NNP work_zbi2knhp65ho5n7vbsuthmd7gi 300 36 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 300 37 VMFLTMAC4 VMFLTMAC4 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 300 38 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 300 39 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 301 1 Cellular cellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 301 2 ATP atp NN work_zbi2knhp65ho5n7vbsuthmd7gi 301 3 determination determination NN work_zbi2knhp65ho5n7vbsuthmd7gi 301 4 Cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 301 5 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 301 6 seeded seed VBN work_zbi2knhp65ho5n7vbsuthmd7gi 301 7 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 301 8 50,000 50,000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 301 9 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 301 10 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 301 11 dish dish NN work_zbi2knhp65ho5n7vbsuthmd7gi 301 12 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 301 13 35-mm 35-mm NNP work_zbi2knhp65ho5n7vbsuthmd7gi 301 14 dishes dish NNS work_zbi2knhp65ho5n7vbsuthmd7gi 301 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 302 1 After after IN work_zbi2knhp65ho5n7vbsuthmd7gi 302 2 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 302 3 h h NNS work_zbi2knhp65ho5n7vbsuthmd7gi 302 4 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 302 5 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 302 6 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 302 7 treated treat VBN work_zbi2knhp65ho5n7vbsuthmd7gi 302 8 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 302 9 test test NN work_zbi2knhp65ho5n7vbsuthmd7gi 302 10 compound compound NN work_zbi2knhp65ho5n7vbsuthmd7gi 302 11 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 302 12 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 302 13 ≤ ≤ NN work_zbi2knhp65ho5n7vbsuthmd7gi 302 14 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 302 15 μM μm NN work_zbi2knhp65ho5n7vbsuthmd7gi 302 16 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 302 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 303 1 At at IN work_zbi2knhp65ho5n7vbsuthmd7gi 303 2 various various JJ work_zbi2knhp65ho5n7vbsuthmd7gi 303 3 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 4 points point NNS work_zbi2knhp65ho5n7vbsuthmd7gi 303 5 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 303 6 ≤ ≤ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 303 7 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 303 8 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 9 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 303 10 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 303 11 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 303 12 counted count VBN work_zbi2knhp65ho5n7vbsuthmd7gi 303 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 303 14 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 303 15 ATP atp NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 16 content content NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 17 per per IN work_zbi2knhp65ho5n7vbsuthmd7gi 303 18 5,000 5,000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 303 19 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 303 20 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 303 21 determined determine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 303 22 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 303 23 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 303 24 CellTiter CellTiter NNP work_zbi2knhp65ho5n7vbsuthmd7gi 303 25 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 303 26 Glo Glo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 303 27 lumines- lumines- NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 28 cent cent NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 29 assay assay NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 30 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 303 31 Promega Promega NNP work_zbi2knhp65ho5n7vbsuthmd7gi 303 32 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 303 33 G7571 G7571 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 303 34 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 303 35 according accord VBG work_zbi2knhp65ho5n7vbsuthmd7gi 303 36 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 303 37 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 303 38 manufacturer manufacturer NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 39 ’s ’s POS work_zbi2knhp65ho5n7vbsuthmd7gi 303 40 © © CD work_zbi2knhp65ho5n7vbsuthmd7gi 303 41 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 303 42 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 303 43 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 44 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 303 45 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 46 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 303 47 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 48 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 303 49 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 303 50 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 303 51 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 303 52 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 303 53 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 303 54 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 55 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 303 56 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 57 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 58 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 303 59 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 303 60 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 303 61 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 303 62 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 303 63 www.landesbioscience.com www.landesbioscience.com NNP work_zbi2knhp65ho5n7vbsuthmd7gi 303 64 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 303 65 2099 2099 CD work_zbi2knhp65ho5n7vbsuthmd7gi 303 66 instructions instruction NNS work_zbi2knhp65ho5n7vbsuthmd7gi 303 67 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 303 68 published publish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 303 69 earlier.59,65,90 earlier.59,65,90 NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 70 Data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 303 71 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 303 72 normalized normalized JJ work_zbi2knhp65ho5n7vbsuthmd7gi 303 73 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 303 74 ATP atp NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 75 content content NN work_zbi2knhp65ho5n7vbsuthmd7gi 303 76 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 303 77 untreated untreated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 303 78 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 303 79 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 304 1 Mitochondrial mitochondrial NN work_zbi2knhp65ho5n7vbsuthmd7gi 304 2 transmembrane transmembrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 304 3 potential potential JJ work_zbi2knhp65ho5n7vbsuthmd7gi 304 4 Mitochondrial Mitochondrial NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 5 transmembrane transmembrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 304 6 potential potential NN work_zbi2knhp65ho5n7vbsuthmd7gi 304 7 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 304 8 Δψm Δψm NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 9 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 304 10 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 304 11 assessed assess VBN work_zbi2knhp65ho5n7vbsuthmd7gi 304 12 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 304 13 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 304 14 potentiometric potentiometric NN work_zbi2knhp65ho5n7vbsuthmd7gi 304 15 dye dye NN work_zbi2knhp65ho5n7vbsuthmd7gi 304 16 5,5́ 5,5́ CD work_zbi2knhp65ho5n7vbsuthmd7gi 304 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 304 18 6,6́ 6,6́ CD work_zbi2knhp65ho5n7vbsuthmd7gi 304 19 -tetrachloro-1,1́ -tetrachloro-1,1́ NN work_zbi2knhp65ho5n7vbsuthmd7gi 304 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 304 21 3,3 3,3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 304 22 -́ -́ : work_zbi2knhp65ho5n7vbsuthmd7gi 304 23 tetraethylbenzimidazolyl tetraethylbenzimidazolyl JJ work_zbi2knhp65ho5n7vbsuthmd7gi 304 24 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 304 25 carbocyanine carbocyanine JJ work_zbi2knhp65ho5n7vbsuthmd7gi 304 26 iodide iodide NN work_zbi2knhp65ho5n7vbsuthmd7gi 304 27 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 304 28 JC-1 JC-1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 29 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 304 30 Sigma Sigma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 31 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 304 32 T4069 T4069 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 33 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 304 34 following follow VBG work_zbi2knhp65ho5n7vbsuthmd7gi 304 35 our -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 304 36 published publish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 304 37 procedure.33,64 procedure.33,64 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 38 In in IN work_zbi2knhp65ho5n7vbsuthmd7gi 304 39 brief brief NN work_zbi2knhp65ho5n7vbsuthmd7gi 304 40 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 304 41 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 304 42 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 304 43 trypsinized trypsinize VBN work_zbi2knhp65ho5n7vbsuthmd7gi 304 44 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 304 45 washed wash VBN work_zbi2knhp65ho5n7vbsuthmd7gi 304 46 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 304 47 PBS PBS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 48 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 304 49 resuspended resuspend VBD work_zbi2knhp65ho5n7vbsuthmd7gi 304 50 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 304 51 300 300 CD work_zbi2knhp65ho5n7vbsuthmd7gi 304 52 µl µl IN work_zbi2knhp65ho5n7vbsuthmd7gi 304 53 PBS PBS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 54 containing contain VBG work_zbi2knhp65ho5n7vbsuthmd7gi 304 55 5 5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 304 56 µg µg IN work_zbi2knhp65ho5n7vbsuthmd7gi 304 57 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 304 58 ml ml NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 59 JC-1 JC-1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 60 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 304 61 15 15 CD work_zbi2knhp65ho5n7vbsuthmd7gi 304 62 min min NN work_zbi2knhp65ho5n7vbsuthmd7gi 304 63 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 304 64 37 37 CD work_zbi2knhp65ho5n7vbsuthmd7gi 304 65 ° ° NNS work_zbi2knhp65ho5n7vbsuthmd7gi 304 66 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 67 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 304 68 5 5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 304 69 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 304 70 CO CO NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 71 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 304 72 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 304 73 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 304 74 dark dark NN work_zbi2knhp65ho5n7vbsuthmd7gi 304 75 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 304 76 then then RB work_zbi2knhp65ho5n7vbsuthmd7gi 304 77 washed wash VBD work_zbi2knhp65ho5n7vbsuthmd7gi 304 78 twice twice RB work_zbi2knhp65ho5n7vbsuthmd7gi 304 79 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 304 80 PBS PBS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 81 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 304 82 resuspended resuspend VBD work_zbi2knhp65ho5n7vbsuthmd7gi 304 83 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 304 84 300 300 CD work_zbi2knhp65ho5n7vbsuthmd7gi 304 85 µl µl IN work_zbi2knhp65ho5n7vbsuthmd7gi 304 86 PBS PBS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 304 87 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 305 1 Bivariate bivariate JJ work_zbi2knhp65ho5n7vbsuthmd7gi 305 2 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 305 3 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 305 4 performed perform VBN work_zbi2knhp65ho5n7vbsuthmd7gi 305 5 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 305 6 flow flow NN work_zbi2knhp65ho5n7vbsuthmd7gi 305 7 cytometry cytometry NN work_zbi2knhp65ho5n7vbsuthmd7gi 305 8 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 305 9 excitation excitation NN work_zbi2knhp65ho5n7vbsuthmd7gi 305 10 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 305 11 488 488 CD work_zbi2knhp65ho5n7vbsuthmd7gi 305 12 nm nm CD work_zbi2knhp65ho5n7vbsuthmd7gi 305 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 305 14 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 305 15 mitochondrial mitochondrial NN work_zbi2knhp65ho5n7vbsuthmd7gi 305 16 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 305 17 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 305 18 assessed assess VBN work_zbi2knhp65ho5n7vbsuthmd7gi 305 19 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 305 20 JC-1 JC-1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 305 21 green green JJ work_zbi2knhp65ho5n7vbsuthmd7gi 305 22 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 305 23 depolarized depolarize VBN work_zbi2knhp65ho5n7vbsuthmd7gi 305 24 mitochondria mitochondrion NNS work_zbi2knhp65ho5n7vbsuthmd7gi 305 25 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 305 26 detector detector NNP work_zbi2knhp65ho5n7vbsuthmd7gi 305 27 FL-1 FL-1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 305 28 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 305 29 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 305 30 red red NNP work_zbi2knhp65ho5n7vbsuthmd7gi 305 31 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 305 32 polarized polarize VBD work_zbi2knhp65ho5n7vbsuthmd7gi 305 33 mitochondria mitochondria NNP work_zbi2knhp65ho5n7vbsuthmd7gi 305 34 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 305 35 detector detector NN work_zbi2knhp65ho5n7vbsuthmd7gi 305 36 FL-2 FL-2 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 305 37 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 305 38 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 305 39 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 306 1 Enzymatic enzymatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 306 2 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 306 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 306 4 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 306 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 306 6 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 306 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 306 8 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 306 9 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 306 10 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 306 11 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 306 12 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 306 13 measured measure VBN work_zbi2knhp65ho5n7vbsuthmd7gi 306 14 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 306 15 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 306 16 fluorimetric fluorimetric JJ work_zbi2knhp65ho5n7vbsuthmd7gi 306 17 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 306 18 activ- activ- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 306 19 ity ity NN work_zbi2knhp65ho5n7vbsuthmd7gi 306 20 assay assay NNP work_zbi2knhp65ho5n7vbsuthmd7gi 306 21 kit kit NNP work_zbi2knhp65ho5n7vbsuthmd7gi 306 22 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 306 23 BioVision BioVision NNP work_zbi2knhp65ho5n7vbsuthmd7gi 306 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 306 25 K140 K140 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 306 26 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 306 27 100 100 CD work_zbi2knhp65ho5n7vbsuthmd7gi 306 28 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 306 29 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 306 30 according accord VBG work_zbi2knhp65ho5n7vbsuthmd7gi 306 31 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 306 32 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 306 33 manufac- manufac- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 306 34 turer turer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 306 35 ’s ’s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 306 36 instructions instruction NNS work_zbi2knhp65ho5n7vbsuthmd7gi 306 37 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 306 38 published publish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 306 39 recently.8,38 recently.8,38 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 306 40 Cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 306 41 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 306 42 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 306 43 × × CD work_zbi2knhp65ho5n7vbsuthmd7gi 306 44 106 106 CD work_zbi2knhp65ho5n7vbsuthmd7gi 306 45 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 306 46 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 306 47 lysed lyse VBN work_zbi2knhp65ho5n7vbsuthmd7gi 306 48 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 306 49 0.5 0.5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 306 50 ml ml NN work_zbi2knhp65ho5n7vbsuthmd7gi 306 51 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 306 52 chilled chill VBN work_zbi2knhp65ho5n7vbsuthmd7gi 306 53 lysis lysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 306 54 buffer buffer NN work_zbi2knhp65ho5n7vbsuthmd7gi 306 55 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 307 1 After after IN work_zbi2knhp65ho5n7vbsuthmd7gi 307 2 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 307 3 min min NN work_zbi2knhp65ho5n7vbsuthmd7gi 307 4 incubation incubation NN work_zbi2knhp65ho5n7vbsuthmd7gi 307 5 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 307 6 ice ice NN work_zbi2knhp65ho5n7vbsuthmd7gi 307 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 307 8 lysates lysate NNS work_zbi2knhp65ho5n7vbsuthmd7gi 307 9 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 307 10 centrifuged centrifuge VBN work_zbi2knhp65ho5n7vbsuthmd7gi 307 11 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 307 12 10,000 10,000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 307 13 g g NN work_zbi2knhp65ho5n7vbsuthmd7gi 307 14 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 307 15 4 4 CD work_zbi2knhp65ho5n7vbsuthmd7gi 307 16 ° ° , work_zbi2knhp65ho5n7vbsuthmd7gi 307 17 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 307 18 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 307 19 5 5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 307 20 min min NN work_zbi2knhp65ho5n7vbsuthmd7gi 307 21 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 307 22 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 307 23 supernatant supernatant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 307 24 fraction fraction NN work_zbi2knhp65ho5n7vbsuthmd7gi 307 25 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 307 26 retained retain VBN work_zbi2knhp65ho5n7vbsuthmd7gi 307 27 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 307 28 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 307 29 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 308 1 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 308 2 μl μl NN work_zbi2knhp65ho5n7vbsuthmd7gi 308 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 308 4 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 308 5 lysate lysate NN work_zbi2knhp65ho5n7vbsuthmd7gi 308 6 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 308 7 incubated incubate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 308 8 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 308 9 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 308 10 μl μl NN work_zbi2knhp65ho5n7vbsuthmd7gi 308 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 308 12 reaction reaction NN work_zbi2knhp65ho5n7vbsuthmd7gi 308 13 buffer buffer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 308 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 309 1 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 309 2 substrate substrate NN work_zbi2knhp65ho5n7vbsuthmd7gi 309 3 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 309 4 Ac Ac NNP work_zbi2knhp65ho5n7vbsuthmd7gi 309 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 309 6 RR RR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 309 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 309 8 AFC AFC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 309 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 309 10 200 200 CD work_zbi2knhp65ho5n7vbsuthmd7gi 309 11 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 309 12 final final JJ work_zbi2knhp65ho5n7vbsuthmd7gi 309 13 concentration concentration NN work_zbi2knhp65ho5n7vbsuthmd7gi 309 14 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 309 15 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 309 16 then then RB work_zbi2knhp65ho5n7vbsuthmd7gi 309 17 added add VBN work_zbi2knhp65ho5n7vbsuthmd7gi 309 18 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 309 19 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 309 20 mixture mixture NN work_zbi2knhp65ho5n7vbsuthmd7gi 309 21 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 309 22 incubated incubate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 309 23 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 309 24 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 309 25 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 309 26 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 309 27 37 37 CD work_zbi2knhp65ho5n7vbsuthmd7gi 309 28 ° ° NNS work_zbi2knhp65ho5n7vbsuthmd7gi 309 29 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 309 30 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 310 1 As as IN work_zbi2knhp65ho5n7vbsuthmd7gi 310 2 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 310 3 negative negative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 310 4 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 310 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 310 6 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 310 7 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 310 8 performed perform VBN work_zbi2knhp65ho5n7vbsuthmd7gi 310 9 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 310 10 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 310 11 presence presence NN work_zbi2knhp65ho5n7vbsuthmd7gi 310 12 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 310 13 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 310 14 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 310 15 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 310 16 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 310 17 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 310 18 Z Z NNP work_zbi2knhp65ho5n7vbsuthmd7gi 310 19 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 310 20 Phe Phe NNP work_zbi2knhp65ho5n7vbsuthmd7gi 310 21 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 310 22 Phe Phe NNP work_zbi2knhp65ho5n7vbsuthmd7gi 310 23 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 310 24 FMK FMK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 310 25 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 310 26 Sigma Sigma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 310 27 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 310 28 C9109 C9109 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 310 29 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 310 30 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 310 31 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 310 32 final final JJ work_zbi2knhp65ho5n7vbsuthmd7gi 310 33 concentration concentration NN work_zbi2knhp65ho5n7vbsuthmd7gi 310 34 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 310 35 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 311 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 311 2 release release NN work_zbi2knhp65ho5n7vbsuthmd7gi 311 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 311 4 free free JJ work_zbi2knhp65ho5n7vbsuthmd7gi 311 5 amino-4-trifluoromethylcoumarin amino-4-trifluoromethylcoumarin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 311 6 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 311 7 AFC AFC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 311 8 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 311 9 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 311 10 measured measure VBN work_zbi2knhp65ho5n7vbsuthmd7gi 311 11 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 311 12 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 311 13 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 311 14 plate plate NN work_zbi2knhp65ho5n7vbsuthmd7gi 311 15 reader reader NN work_zbi2knhp65ho5n7vbsuthmd7gi 311 16 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 311 17 λex λex NNP work_zbi2knhp65ho5n7vbsuthmd7gi 311 18 400 400 CD work_zbi2knhp65ho5n7vbsuthmd7gi 311 19 nm nm CD work_zbi2knhp65ho5n7vbsuthmd7gi 311 20 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 311 21 λem λem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 311 22 505 505 CD work_zbi2knhp65ho5n7vbsuthmd7gi 311 23 nm nm UH work_zbi2knhp65ho5n7vbsuthmd7gi 311 24 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 311 25 SpectraMax SpectraMax NNP work_zbi2knhp65ho5n7vbsuthmd7gi 311 26 Gemini Gemini NNP work_zbi2knhp65ho5n7vbsuthmd7gi 311 27 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 311 28 Molecular Molecular NNP work_zbi2knhp65ho5n7vbsuthmd7gi 311 29 Devices Devices NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 311 30 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 311 31 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 312 1 Protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 312 2 con- con- NN work_zbi2knhp65ho5n7vbsuthmd7gi 312 3 centration centration NN work_zbi2knhp65ho5n7vbsuthmd7gi 312 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 312 5 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 312 6 lysates lysate NNS work_zbi2knhp65ho5n7vbsuthmd7gi 312 7 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 312 8 determined determine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 312 9 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 312 10 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 312 11 BCA BCA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 312 12 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 312 13 assay assay NN work_zbi2knhp65ho5n7vbsuthmd7gi 312 14 kit kit NN work_zbi2knhp65ho5n7vbsuthmd7gi 312 15 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 312 16 Pierce Pierce NNP work_zbi2knhp65ho5n7vbsuthmd7gi 312 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 312 18 23227 23227 CD work_zbi2knhp65ho5n7vbsuthmd7gi 312 19 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 312 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 312 21 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 312 22 cathepsin cathepsin NN work_zbi2knhp65ho5n7vbsuthmd7gi 312 23 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 312 24 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 312 25 normalized normalize VBN work_zbi2knhp65ho5n7vbsuthmd7gi 312 26 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 312 27 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 312 28 concentrations concentration NNS work_zbi2knhp65ho5n7vbsuthmd7gi 312 29 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 313 1 CTSD CTSD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 313 3 CTSL CTSL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 4 activities activity NNS work_zbi2knhp65ho5n7vbsuthmd7gi 313 5 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 313 6 determined determine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 313 7 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 313 8 fluorimet- fluorimet- NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 9 ric ric NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 10 assay assay NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 11 kits kits NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 313 12 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 313 13 BioVision BioVision NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 313 15 K143 K143 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 16 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 313 17 100 100 CD work_zbi2knhp65ho5n7vbsuthmd7gi 313 18 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 313 19 K142 K142 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 20 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 313 21 100 100 CD work_zbi2knhp65ho5n7vbsuthmd7gi 313 22 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 313 23 according accord VBG work_zbi2knhp65ho5n7vbsuthmd7gi 313 24 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 25 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 313 26 manufacturer manufacturer NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 27 ’s ’s POS work_zbi2knhp65ho5n7vbsuthmd7gi 313 28 instructions instruction NNS work_zbi2knhp65ho5n7vbsuthmd7gi 313 29 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 30 published publish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 313 31 recently.8 recently.8 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 32 Processing Processing NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 33 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 34 samples sample NNS work_zbi2knhp65ho5n7vbsuthmd7gi 313 35 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 313 36 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 313 37 protocol protocol NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 38 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 313 39 identical identical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 313 40 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 41 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 313 42 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 43 activ- activ- VBD work_zbi2knhp65ho5n7vbsuthmd7gi 313 44 ity ity NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 45 assay assay NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 46 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 47 described describe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 313 48 above above RB work_zbi2knhp65ho5n7vbsuthmd7gi 313 49 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 50 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 313 51 following follow VBG work_zbi2knhp65ho5n7vbsuthmd7gi 313 52 modifications modification NNS work_zbi2knhp65ho5n7vbsuthmd7gi 313 53 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 313 54 CTSL CTSL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 55 determination determination NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 56 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 313 57 After after IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 58 lysis lysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 59 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 313 60 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 313 61 μL μL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 62 lysate lysate NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 63 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 313 64 incubated incubate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 313 65 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 66 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 313 67 μL μL NNS work_zbi2knhp65ho5n7vbsuthmd7gi 313 68 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 69 reaction reaction NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 70 buffer buffer NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 71 containing contain VBG work_zbi2knhp65ho5n7vbsuthmd7gi 313 72 Ca074 Ca074 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 73 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 313 74 Sigma Sigma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 75 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 313 76 C5732 c5732 NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 77 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 313 78 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 313 79 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 80 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 313 81 15 15 CD work_zbi2knhp65ho5n7vbsuthmd7gi 313 82 min min NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 83 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 313 84 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 313 85 irreversibly irreversibly RB work_zbi2knhp65ho5n7vbsuthmd7gi 313 86 inhibit inhibit VB work_zbi2knhp65ho5n7vbsuthmd7gi 313 87 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 88 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 313 89 thereby thereby RB work_zbi2knhp65ho5n7vbsuthmd7gi 313 90 eliminating eliminate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 313 91 interference interference NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 92 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 93 CTSB CTSB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 94 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 313 95 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 313 96 cleavage cleavage NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 97 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 98 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 313 99 substrate.91,92 substrate.91,92 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 100 CTSL CTSL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 101 substrate substrate NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 102 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 313 103 Ac Ac NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 104 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 313 105 Phe Phe NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 106 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 313 107 Arg Arg NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 108 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 313 109 AFC AFC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 110 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 313 111 Abcam Abcam NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 112 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 313 113 ab157769 ab157769 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 114 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 313 115 200 200 CD work_zbi2knhp65ho5n7vbsuthmd7gi 313 116 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 117 final final JJ work_zbi2knhp65ho5n7vbsuthmd7gi 313 118 concentration concentration NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 119 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 313 120 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 313 121 then then RB work_zbi2knhp65ho5n7vbsuthmd7gi 313 122 added add VBN work_zbi2knhp65ho5n7vbsuthmd7gi 313 123 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 313 124 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 313 125 mixture mixture NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 126 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 313 127 incu- incu- NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 128 bated bate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 313 129 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 130 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 313 131 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 132 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 133 37 37 CD work_zbi2knhp65ho5n7vbsuthmd7gi 313 134 ° ° NNS work_zbi2knhp65ho5n7vbsuthmd7gi 313 135 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 136 followed follow VBN work_zbi2knhp65ho5n7vbsuthmd7gi 313 137 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 138 AFC AFC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 139 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 313 140 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 313 141 λex λex NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 142 400 400 CD work_zbi2knhp65ho5n7vbsuthmd7gi 313 143 nm nm CD work_zbi2knhp65ho5n7vbsuthmd7gi 313 144 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 313 145 λem λem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 313 146 505 505 CD work_zbi2knhp65ho5n7vbsuthmd7gi 313 147 nm nm IN work_zbi2knhp65ho5n7vbsuthmd7gi 313 148 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 313 149 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 314 1 As as IN work_zbi2knhp65ho5n7vbsuthmd7gi 314 2 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 314 3 negative negative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 314 4 control control NN work_zbi2knhp65ho5n7vbsuthmd7gi 314 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 314 6 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 314 7 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 314 8 performed perform VBN work_zbi2knhp65ho5n7vbsuthmd7gi 314 9 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 314 10 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 314 11 presence presence NN work_zbi2knhp65ho5n7vbsuthmd7gi 314 12 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 314 13 Z Z NNP work_zbi2knhp65ho5n7vbsuthmd7gi 314 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 314 15 Phe Phe NNP work_zbi2knhp65ho5n7vbsuthmd7gi 314 16 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 314 17 Phe Phe NNP work_zbi2knhp65ho5n7vbsuthmd7gi 314 18 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 314 19 FMK FMK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 314 20 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 314 21 200 200 CD work_zbi2knhp65ho5n7vbsuthmd7gi 314 22 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 314 23 final final JJ work_zbi2knhp65ho5n7vbsuthmd7gi 314 24 concentra- concentra- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 314 25 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 314 26 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 314 27 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 315 1 CTSD ctsd JJ work_zbi2knhp65ho5n7vbsuthmd7gi 315 2 determination determination NN work_zbi2knhp65ho5n7vbsuthmd7gi 315 3 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 315 4 Using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 315 5 CTSD CTSD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 315 6 substrate substrate NN work_zbi2knhp65ho5n7vbsuthmd7gi 315 7 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 315 8 MCA- MCA- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 315 9 GKPILFFRLK[Dnp]-DR GKPILFFRLK[Dnp]-DR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 315 10 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 315 11 NH2 NH2 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 315 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 315 13 Abcam Abcam NNP work_zbi2knhp65ho5n7vbsuthmd7gi 315 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 315 15 ab126779 ab126779 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 315 16 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 315 17 200 200 CD work_zbi2knhp65ho5n7vbsuthmd7gi 315 18 µM µM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 315 19 final final JJ work_zbi2knhp65ho5n7vbsuthmd7gi 315 20 concentration concentration NN work_zbi2knhp65ho5n7vbsuthmd7gi 315 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 315 22 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 315 23 release release NN work_zbi2knhp65ho5n7vbsuthmd7gi 315 24 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 315 25 free free JJ work_zbi2knhp65ho5n7vbsuthmd7gi 315 26 7-methoxycoumarin-4-yl 7-methoxycoumarin-4-yl CD work_zbi2knhp65ho5n7vbsuthmd7gi 315 27 acetyl acetyl NN work_zbi2knhp65ho5n7vbsuthmd7gi 315 28 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 315 29 measured measure VBN work_zbi2knhp65ho5n7vbsuthmd7gi 315 30 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 315 31 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 315 32 fluorescence fluorescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 315 33 plate plate NN work_zbi2knhp65ho5n7vbsuthmd7gi 315 34 reader reader NN work_zbi2knhp65ho5n7vbsuthmd7gi 315 35 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 315 36 λex λex NNP work_zbi2knhp65ho5n7vbsuthmd7gi 315 37 328 328 CD work_zbi2knhp65ho5n7vbsuthmd7gi 315 38 nm nm NN work_zbi2knhp65ho5n7vbsuthmd7gi 315 39 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 315 40 λem λem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 315 41 460 460 CD work_zbi2knhp65ho5n7vbsuthmd7gi 315 42 nm nm RB work_zbi2knhp65ho5n7vbsuthmd7gi 315 43 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 315 44 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 316 1 Human Human NNP work_zbi2knhp65ho5n7vbsuthmd7gi 316 2 Stress Stress NNP work_zbi2knhp65ho5n7vbsuthmd7gi 316 3 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 316 4 Toxicity Toxicity NNP work_zbi2knhp65ho5n7vbsuthmd7gi 316 5 RT2ProfilerTM RT2ProfilerTM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 316 6 PCR PCR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 316 7 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 316 8 array array VBP work_zbi2knhp65ho5n7vbsuthmd7gi 316 9 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 316 10 After after IN work_zbi2knhp65ho5n7vbsuthmd7gi 316 11 pharmacological pharmacological JJ work_zbi2knhp65ho5n7vbsuthmd7gi 316 12 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 316 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 316 14 total total JJ work_zbi2knhp65ho5n7vbsuthmd7gi 316 15 cellular cellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 316 16 RNA RNA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 316 17 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 316 18 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 316 19 × × CD work_zbi2knhp65ho5n7vbsuthmd7gi 316 20 106 106 CD work_zbi2knhp65ho5n7vbsuthmd7gi 316 21 A375 a375 CD work_zbi2knhp65ho5n7vbsuthmd7gi 316 22 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 316 23 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 316 24 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 316 25 prepared prepare VBN work_zbi2knhp65ho5n7vbsuthmd7gi 316 26 according accord VBG work_zbi2knhp65ho5n7vbsuthmd7gi 316 27 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 316 28 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 316 29 standard standard JJ work_zbi2knhp65ho5n7vbsuthmd7gi 316 30 procedure procedure NN work_zbi2knhp65ho5n7vbsuthmd7gi 316 31 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 316 32 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 316 33 RNeasy rneasy JJ work_zbi2knhp65ho5n7vbsuthmd7gi 316 34 kit kit NN work_zbi2knhp65ho5n7vbsuthmd7gi 316 35 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 316 36 Qiagen Qiagen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 316 37 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 316 38 74104 74104 CD work_zbi2knhp65ho5n7vbsuthmd7gi 316 39 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 316 40 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 317 1 Reverse reverse JJ work_zbi2knhp65ho5n7vbsuthmd7gi 317 2 transcription transcription NN work_zbi2knhp65ho5n7vbsuthmd7gi 317 3 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 317 4 performed perform VBN work_zbi2knhp65ho5n7vbsuthmd7gi 317 5 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 317 6 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 317 7 RT2 RT2 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 8 First First NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 9 Strand Strand NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 10 kit kit NN work_zbi2knhp65ho5n7vbsuthmd7gi 317 11 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 317 12 Superarray Superarray NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 317 14 330401 330401 CD work_zbi2knhp65ho5n7vbsuthmd7gi 317 15 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 317 16 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 317 17 5 5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 317 18 µg µg NN work_zbi2knhp65ho5n7vbsuthmd7gi 317 19 total total NN work_zbi2knhp65ho5n7vbsuthmd7gi 317 20 RNA RNA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 21 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 317 22 described describe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 317 23 previously.33,62 previously.33,62 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 24 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 317 25 Human Human NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 26 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 27 RT2ProfilerTM RT2ProfilerTM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 28 PCR PCR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 29 Expression Expression NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 30 Array Array NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 31 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 317 32 Qiagen Qiagen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 33 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 317 34 PAHS- PAHS- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 35 084ZA-12 084ZA-12 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 317 36 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 317 37 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 317 38 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 317 39 Human Human NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 40 Stress Stress NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 41 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 317 42 Toxicity Toxicity NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 43 RT2ProfilerTM RT2ProfilerTM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 44 PCR PCR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 45 Expression Expression NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 46 Array Array NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 47 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 317 48 Qiagen Qiagen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 49 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 317 50 PAHS-003A-12 PAHS-003A-12 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 51 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 317 52 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 317 53 each each DT work_zbi2knhp65ho5n7vbsuthmd7gi 317 54 profil- profil- NN work_zbi2knhp65ho5n7vbsuthmd7gi 317 55 ing e VBG work_zbi2knhp65ho5n7vbsuthmd7gi 317 56 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 317 57 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 317 58 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 317 59 84 84 CD work_zbi2knhp65ho5n7vbsuthmd7gi 317 60 genes gene NNS work_zbi2knhp65ho5n7vbsuthmd7gi 317 61 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 317 62 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 317 63 run run VBN work_zbi2knhp65ho5n7vbsuthmd7gi 317 64 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 317 65 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 317 66 following follow VBG work_zbi2knhp65ho5n7vbsuthmd7gi 317 67 PCR PCR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 68 conditions condition NNS work_zbi2knhp65ho5n7vbsuthmd7gi 317 69 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 317 70 95 95 CD work_zbi2knhp65ho5n7vbsuthmd7gi 317 71 ° ° , work_zbi2knhp65ho5n7vbsuthmd7gi 317 72 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 73 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 317 74 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 317 75 min min NN work_zbi2knhp65ho5n7vbsuthmd7gi 317 76 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 317 77 followed follow VBN work_zbi2knhp65ho5n7vbsuthmd7gi 317 78 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 317 79 40 40 CD work_zbi2knhp65ho5n7vbsuthmd7gi 317 80 cycles cycle NNS work_zbi2knhp65ho5n7vbsuthmd7gi 317 81 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 317 82 95 95 CD work_zbi2knhp65ho5n7vbsuthmd7gi 317 83 ° ° , work_zbi2knhp65ho5n7vbsuthmd7gi 317 84 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 85 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 317 86 15 15 CD work_zbi2knhp65ho5n7vbsuthmd7gi 317 87 s s NN work_zbi2knhp65ho5n7vbsuthmd7gi 317 88 alternating alternate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 317 89 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 317 90 60 60 CD work_zbi2knhp65ho5n7vbsuthmd7gi 317 91 ° ° NNS work_zbi2knhp65ho5n7vbsuthmd7gi 317 92 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 93 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 317 94 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 317 95 min min NN work_zbi2knhp65ho5n7vbsuthmd7gi 317 96 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 317 97 Applied Applied NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 98 Biosystems Biosystems NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 317 99 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 317 100 7000 7000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 317 101 SDS SDS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 317 102 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 317 103 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 318 1 Gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 318 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 318 3 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 318 4 product product NN work_zbi2knhp65ho5n7vbsuthmd7gi 318 5 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 318 6 normalized normalize VBN work_zbi2knhp65ho5n7vbsuthmd7gi 318 7 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 318 8 GAPDH GAPDH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 318 9 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 318 10 quantified quantify VBD work_zbi2knhp65ho5n7vbsuthmd7gi 318 11 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 318 12 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 318 13 comparative comparative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 318 14 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 318 15 ΔΔC ΔΔC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 318 16 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 318 17 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 318 18 Ct Ct NNP work_zbi2knhp65ho5n7vbsuthmd7gi 318 19 method method NN work_zbi2knhp65ho5n7vbsuthmd7gi 318 20 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 318 21 described describe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 318 22 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 318 23 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 318 24 ABI ABI NNP work_zbi2knhp65ho5n7vbsuthmd7gi 318 25 Prism Prism NNP work_zbi2knhp65ho5n7vbsuthmd7gi 318 26 7000 7000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 318 27 sequence sequence NN work_zbi2knhp65ho5n7vbsuthmd7gi 318 28 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 318 29 system system NN work_zbi2knhp65ho5n7vbsuthmd7gi 318 30 user user NN work_zbi2knhp65ho5n7vbsuthmd7gi 318 31 guide guide NN work_zbi2knhp65ho5n7vbsuthmd7gi 318 32 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 318 33 published publish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 318 34 earlier.33,62 earlier.33,62 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 318 35 Expression Expression NNP work_zbi2knhp65ho5n7vbsuthmd7gi 318 36 values value NNS work_zbi2knhp65ho5n7vbsuthmd7gi 318 37 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 318 38 averaged average VBN work_zbi2knhp65ho5n7vbsuthmd7gi 318 39 across across IN work_zbi2knhp65ho5n7vbsuthmd7gi 318 40 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 318 41 independent independent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 318 42 array array NN work_zbi2knhp65ho5n7vbsuthmd7gi 318 43 experiments experiment NNS work_zbi2knhp65ho5n7vbsuthmd7gi 318 44 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 318 45 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 318 46 standard standard JJ work_zbi2knhp65ho5n7vbsuthmd7gi 318 47 deviation deviation NN work_zbi2knhp65ho5n7vbsuthmd7gi 318 48 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 318 49 cal- cal- NN work_zbi2knhp65ho5n7vbsuthmd7gi 318 50 culated culate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 318 51 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 318 52 graphing graph VBG work_zbi2knhp65ho5n7vbsuthmd7gi 318 53 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 319 1 Gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 319 2 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 319 3 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 319 4 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 319 5 real real JJ work_zbi2knhp65ho5n7vbsuthmd7gi 319 6 time time NN work_zbi2knhp65ho5n7vbsuthmd7gi 319 7 RT RT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 319 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 319 9 PCR PCR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 319 10 After after IN work_zbi2knhp65ho5n7vbsuthmd7gi 319 11 AQ AQ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 319 12 exposure exposure NN work_zbi2knhp65ho5n7vbsuthmd7gi 319 13 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 319 14 1–20 1–20 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 319 15 μM μM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 319 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 319 17 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 319 18 h h NN work_zbi2knhp65ho5n7vbsuthmd7gi 319 19 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 319 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 319 21 total total JJ work_zbi2knhp65ho5n7vbsuthmd7gi 319 22 cellular cellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 319 23 RNA RNA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 319 24 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 319 25 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 319 26 × × CD work_zbi2knhp65ho5n7vbsuthmd7gi 319 27 106 106 CD work_zbi2knhp65ho5n7vbsuthmd7gi 319 28 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 319 29 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 319 30 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 319 31 prepared prepare VBN work_zbi2knhp65ho5n7vbsuthmd7gi 319 32 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 319 33 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 319 34 RNEasy RNEasy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 319 35 kit kit NN work_zbi2knhp65ho5n7vbsuthmd7gi 319 36 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 319 37 Qiagen Qiagen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 319 38 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 319 39 74104 74104 CD work_zbi2knhp65ho5n7vbsuthmd7gi 319 40 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 319 41 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 320 1 Reverse reverse JJ work_zbi2knhp65ho5n7vbsuthmd7gi 320 2 transcription transcription NN work_zbi2knhp65ho5n7vbsuthmd7gi 320 3 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 320 4 performed perform VBN work_zbi2knhp65ho5n7vbsuthmd7gi 320 5 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 320 6 TagMan TagMan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 320 7 Reverse Reverse NNP work_zbi2knhp65ho5n7vbsuthmd7gi 320 8 Transcription Transcription NNP work_zbi2knhp65ho5n7vbsuthmd7gi 320 9 Reagents Reagents NNP work_zbi2knhp65ho5n7vbsuthmd7gi 320 10 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 320 11 200 200 CD work_zbi2knhp65ho5n7vbsuthmd7gi 320 12 ng ng NN work_zbi2knhp65ho5n7vbsuthmd7gi 320 13 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 320 14 total total NN work_zbi2knhp65ho5n7vbsuthmd7gi 320 15 RNA RNA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 320 16 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 320 17 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 320 18 50-μl 50-μl NNP work_zbi2knhp65ho5n7vbsuthmd7gi 320 19 reaction reaction NN work_zbi2knhp65ho5n7vbsuthmd7gi 320 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 321 1 Reverse reverse JJ work_zbi2knhp65ho5n7vbsuthmd7gi 321 2 transcription transcription NN work_zbi2knhp65ho5n7vbsuthmd7gi 321 3 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 321 4 primed prime VBN work_zbi2knhp65ho5n7vbsuthmd7gi 321 5 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 321 6 ran- ran- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 321 7 dom dom NN work_zbi2knhp65ho5n7vbsuthmd7gi 321 8 hexamers hexamer NNS work_zbi2knhp65ho5n7vbsuthmd7gi 321 9 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 321 10 incubated incubate VBD work_zbi2knhp65ho5n7vbsuthmd7gi 321 11 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 321 12 25 25 CD work_zbi2knhp65ho5n7vbsuthmd7gi 321 13 ° ° , work_zbi2knhp65ho5n7vbsuthmd7gi 321 14 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 321 15 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 321 16 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 321 17 min min NN work_zbi2knhp65ho5n7vbsuthmd7gi 321 18 followed follow VBN work_zbi2knhp65ho5n7vbsuthmd7gi 321 19 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 321 20 48 48 CD work_zbi2knhp65ho5n7vbsuthmd7gi 321 21 ° ° , work_zbi2knhp65ho5n7vbsuthmd7gi 321 22 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 321 23 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 321 24 30 30 CD work_zbi2knhp65ho5n7vbsuthmd7gi 321 25 min min NN work_zbi2knhp65ho5n7vbsuthmd7gi 321 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 321 27 95 95 CD work_zbi2knhp65ho5n7vbsuthmd7gi 321 28 ° ° , work_zbi2knhp65ho5n7vbsuthmd7gi 321 29 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 321 30 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 321 31 5 5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 321 32 min min NN work_zbi2knhp65ho5n7vbsuthmd7gi 321 33 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 321 34 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 321 35 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 321 36 chill chill NN work_zbi2knhp65ho5n7vbsuthmd7gi 321 37 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 321 38 4 4 CD work_zbi2knhp65ho5n7vbsuthmd7gi 321 39 ° ° NNS work_zbi2knhp65ho5n7vbsuthmd7gi 321 40 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 321 41 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 322 1 Each each DT work_zbi2knhp65ho5n7vbsuthmd7gi 322 2 PCR PCR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 3 reaction reaction NN work_zbi2knhp65ho5n7vbsuthmd7gi 322 4 consisted consist VBD work_zbi2knhp65ho5n7vbsuthmd7gi 322 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 322 6 3.75 3.75 CD work_zbi2knhp65ho5n7vbsuthmd7gi 322 7 μl μl NN work_zbi2knhp65ho5n7vbsuthmd7gi 322 8 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 322 9 cDNA cDNA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 10 added add VBN work_zbi2knhp65ho5n7vbsuthmd7gi 322 11 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 322 12 12.5 12.5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 322 13 μl μl IN work_zbi2knhp65ho5n7vbsuthmd7gi 322 14 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 322 15 TaqMan TaqMan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 16 Universal Universal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 17 PCR PCR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 18 Master Master NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 19 Mix Mix NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 20 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 21 Roche Roche NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 22 Molecular Molecular NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 23 Systems Systems NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 322 24 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 25 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 322 26 1.25 1.25 CD work_zbi2knhp65ho5n7vbsuthmd7gi 322 27 μl μl NN work_zbi2knhp65ho5n7vbsuthmd7gi 322 28 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 322 29 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 322 30 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 322 31 primer primer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 32 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 322 33 probe probe NN work_zbi2knhp65ho5n7vbsuthmd7gi 322 34 mix mix NN work_zbi2knhp65ho5n7vbsuthmd7gi 322 35 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 36 Assay Assay NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 37 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 322 38 by- by- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 39 Design design NN work_zbi2knhp65ho5n7vbsuthmd7gi 322 40 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 322 41 Applied Applied NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 42 Biosystems Biosystems NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 322 43 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 322 44 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 45 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 46 assay assay NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 47 ID ID NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 48 Hs00355782 Hs00355782 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 49 _ _ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 50 m1 m1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 51 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 52 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 322 53 DDIT3 DDIT3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 54 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 55 assay assay NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 56 ID ID NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 57 Hs00358796_g1 Hs00358796_g1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 58 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 59 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 322 60 GADD45A gadd45a JJ work_zbi2knhp65ho5n7vbsuthmd7gi 322 61 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 62 assay assay NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 63 ID ID NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 64 Hs00169255_m1 Hs00169255_m1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 65 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 66 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 322 67 HSPA1A hspa1a UH work_zbi2knhp65ho5n7vbsuthmd7gi 322 68 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 69 assay assay NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 70 ID ID NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 71 Hs00359163_s1 Hs00359163_s1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 72 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 73 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 322 74 EGR1 EGR1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 75 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 76 assay assay NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 77 ID ID NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 78 Hs00152928_m1 Hs00152928_m1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 79 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 80 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 322 81 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 82 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 83 assay assay NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 84 ID ID NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 85 Hs00153451_m1 Hs00153451_m1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 86 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 87 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 322 88 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 322 89 GAPDH GAPDH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 90 [ [ -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 91 assay assay NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 92 ID ID NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 93 Hs99999905_m1 Hs99999905_m1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 94 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 95 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 322 96 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 322 97 7.5 7.5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 322 98 μl μl NN work_zbi2knhp65ho5n7vbsuthmd7gi 322 99 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 322 100 PCR PCR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 322 101 water water NN work_zbi2knhp65ho5n7vbsuthmd7gi 322 102 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 323 1 PCR PCR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 323 2 conditions condition NNS work_zbi2knhp65ho5n7vbsuthmd7gi 323 3 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 323 4 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 323 5 95 95 CD work_zbi2knhp65ho5n7vbsuthmd7gi 323 6 ° ° , work_zbi2knhp65ho5n7vbsuthmd7gi 323 7 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 323 8 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 323 9 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 323 10 min min NN work_zbi2knhp65ho5n7vbsuthmd7gi 323 11 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 323 12 followed follow VBN work_zbi2knhp65ho5n7vbsuthmd7gi 323 13 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 323 14 40 40 CD work_zbi2knhp65ho5n7vbsuthmd7gi 323 15 cycles cycle NNS work_zbi2knhp65ho5n7vbsuthmd7gi 323 16 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 323 17 95 95 CD work_zbi2knhp65ho5n7vbsuthmd7gi 323 18 ° ° , work_zbi2knhp65ho5n7vbsuthmd7gi 323 19 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 323 20 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 323 21 15 15 CD work_zbi2knhp65ho5n7vbsuthmd7gi 323 22 s s NN work_zbi2knhp65ho5n7vbsuthmd7gi 323 23 alternating alternate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 323 24 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 323 25 60 60 CD work_zbi2knhp65ho5n7vbsuthmd7gi 323 26 ° ° NNS work_zbi2knhp65ho5n7vbsuthmd7gi 323 27 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 323 28 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 323 29 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 323 30 min min NN work_zbi2knhp65ho5n7vbsuthmd7gi 323 31 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 323 32 Applied Applied NNP work_zbi2knhp65ho5n7vbsuthmd7gi 323 33 Biosystems Biosystems NNP work_zbi2knhp65ho5n7vbsuthmd7gi 323 34 7000 7000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 323 35 SDS SDS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 323 36 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 323 37 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 324 1 Gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 324 3 specific specific JJ work_zbi2knhp65ho5n7vbsuthmd7gi 324 4 product product NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 5 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 324 6 normalized normalize VBN work_zbi2knhp65ho5n7vbsuthmd7gi 324 7 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 324 8 GAPDH GAPDH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 324 9 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 324 10 quantified quantify VBD work_zbi2knhp65ho5n7vbsuthmd7gi 324 11 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 324 12 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 324 13 comparative comparative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 324 14 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 324 15 ΔΔC ΔΔC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 324 16 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 17 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 324 18 Ct Ct NNP work_zbi2knhp65ho5n7vbsuthmd7gi 324 19 method method NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 20 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 324 21 described describe VBN work_zbi2knhp65ho5n7vbsuthmd7gi 324 22 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 324 23 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 324 24 ABI ABI NNP work_zbi2knhp65ho5n7vbsuthmd7gi 324 25 Prism Prism NNP work_zbi2knhp65ho5n7vbsuthmd7gi 324 26 7000 7000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 324 27 sequence sequence NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 28 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 29 system system NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 30 user user NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 31 guide guide NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 32 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 324 33 published publish VBN work_zbi2knhp65ho5n7vbsuthmd7gi 324 34 earlier.33,62 earlier.33,62 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 324 35 Immunoblot Immunoblot NNP work_zbi2knhp65ho5n7vbsuthmd7gi 324 36 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 37 Cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 324 38 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 324 39 lysed lyse VBN work_zbi2knhp65ho5n7vbsuthmd7gi 324 40 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 324 41 1× 1× NNP work_zbi2knhp65ho5n7vbsuthmd7gi 324 42 SDS SDS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 324 43 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 324 44 PAGE PAGE NNP work_zbi2knhp65ho5n7vbsuthmd7gi 324 45 sample sample NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 46 buffer buffer NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 47 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 324 48 heated heat VBD work_zbi2knhp65ho5n7vbsuthmd7gi 324 49 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 324 50 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 324 51 min min NN work_zbi2knhp65ho5n7vbsuthmd7gi 324 52 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 324 53 95 95 CD work_zbi2knhp65ho5n7vbsuthmd7gi 324 54 ° ° , work_zbi2knhp65ho5n7vbsuthmd7gi 324 55 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 324 56 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 325 1 Samples sample NNS work_zbi2knhp65ho5n7vbsuthmd7gi 325 2 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 325 3 separated separate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 325 4 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 325 5 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 325 6 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 325 7 SDS SDS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 325 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 325 9 PAGE page NN work_zbi2knhp65ho5n7vbsuthmd7gi 325 10 fol- fol- NN work_zbi2knhp65ho5n7vbsuthmd7gi 325 11 lowed low VBN work_zbi2knhp65ho5n7vbsuthmd7gi 325 12 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 325 13 transfer transfer NN work_zbi2knhp65ho5n7vbsuthmd7gi 325 14 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 325 15 Protran Protran NNP work_zbi2knhp65ho5n7vbsuthmd7gi 325 16 nitrocellulose nitrocellulose NNP work_zbi2knhp65ho5n7vbsuthmd7gi 325 17 membranes membrane NNS work_zbi2knhp65ho5n7vbsuthmd7gi 325 18 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 325 19 Whatman Whatman NNP work_zbi2knhp65ho5n7vbsuthmd7gi 325 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 325 21 BA85 BA85 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 325 22 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 325 23 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 326 1 Membranes Membranes NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 2 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 326 3 incubated incubate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 326 4 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 326 5 primary primary JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 6 antibodies antibody NNS work_zbi2knhp65ho5n7vbsuthmd7gi 326 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 326 8 5 5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 9 % % NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 10 milk milk NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 11 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 326 12 TBST TBST NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 13 overnight overnight RB work_zbi2knhp65ho5n7vbsuthmd7gi 326 14 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 326 15 4 4 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 16 ° ° , work_zbi2knhp65ho5n7vbsuthmd7gi 326 17 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 18 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 326 19 follows follow VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 326 20 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 326 21 rabbit rabbit NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 22 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 23 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 24 phos- phos- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 25 pho pho NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 26 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 326 27 RB1(Ser780 RB1(Ser780 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 28 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 29 polyclonal polyclonal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 30 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 31 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 32 Signaling Signaling NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 33 Technology Technology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 34 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 35 9307 9307 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 36 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 37 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 38 rabbit rabbit NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 39 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 40 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 41 phospho phospho JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 42 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 326 43 RB1(Ser807/811 rb1(ser807/811 NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 44 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 45 polyclonal polyclonal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 46 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 47 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 48 Signaling Signaling NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 49 Technology Technology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 50 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 51 9308 9308 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 52 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 53 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 54 mouse mouse NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 55 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 56 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 57 RB1 rb1 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 58 monoclonal monoclonal NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 59 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 60 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 61 Signaling Signaling NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 62 Technology Technology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 63 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 64 9309 9309 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 65 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 66 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 67 mouse mouse NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 68 anti anti NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 69 - - NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 70 CDKN1A CDKN1A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 71 monoclonal monoclonal NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 72 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 73 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 74 Signaling Signaling NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 75 Technology Technology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 76 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 77 2946 2946 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 78 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 79 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 80 rabbit rabbit NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 81 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 82 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 83 LAMP1 lamp1 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 84 monoclonal monoclonal NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 85 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 86 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 87 Signaling Signaling NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 88 Technology Technology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 89 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 90 3243 3243 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 91 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 92 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 93 rabbit rabbit NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 94 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 95 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 96 SNCA snca JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 97 poly- poly- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 98 clonal clonal NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 99 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 100 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 101 Signaling Signaling NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 102 Technology Technology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 103 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 104 4179 4179 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 105 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 106 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 107 rabbit rabbit NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 108 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 109 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 110 RPL13A rpl13a JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 111 polyclonal polyclonal NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 112 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 113 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 114 Signaling Signaling NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 115 Technology Technology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 116 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 117 2765 2765 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 118 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 119 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 120 rabbit rabbit NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 121 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 122 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 123 MYC MYC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 124 monoclonal monoclonal NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 125 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 126 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 127 Signaling Signaling NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 128 Technology Technology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 129 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 130 5605P 5605P NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 131 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 132 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 133 mouse mouse NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 134 anti- anti- NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 135 TP53 tp53 IN work_zbi2knhp65ho5n7vbsuthmd7gi 326 136 monoclonal monoclonal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 137 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 138 Santa Santa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 139 Cruz Cruz NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 140 Biotechnology Biotechnology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 141 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 142 sc-126 sc-126 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 143 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 144 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 145 mouse mouse NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 146 anti anti NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 147 - - NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 148 E2F1 e2f1 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 149 monoclonal monoclonal NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 150 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 151 Santa Santa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 152 Cruz Cruz NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 153 Biotechnology Biotechnology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 154 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 155 sc-251 sc-251 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 156 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 157 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 158 mouse mouse NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 159 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 160 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 161 BECN1 becn1 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 162 monoclonal monoclonal NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 163 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 164 Santa Santa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 165 Cruz Cruz NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 166 Biotechnology Biotechnology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 167 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 168 sc-48341 sc-48341 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 169 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 170 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 171 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 172 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 173 CCND1 ccnd1 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 174 polyclonal polyclonal NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 175 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 176 Santa Santa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 177 Cruz Cruz NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 178 Biotechnology Biotechnology NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 179 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 180 sc-718 sc-718 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 181 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 182 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 183 mouse mouse NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 184 anti anti NNS work_zbi2knhp65ho5n7vbsuthmd7gi 326 185 - - NNS work_zbi2knhp65ho5n7vbsuthmd7gi 326 186 SQSTM1 sqstm1 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 187 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 326 188 p62 p62 NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 189 monoclonal monoclonal NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 190 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 191 Santa Santa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 192 Cruz Cruz NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 193 © © NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 194 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 195 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 196 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 197 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 326 198 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 199 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 200 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 201 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 326 202 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 326 203 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 204 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 326 205 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 206 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 207 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 208 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 326 209 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 210 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 211 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 326 212 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 326 213 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 326 214 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 326 215 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 216 2100 2100 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 217 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 218 Volume Volume NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 219 9 9 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 220 issue issue NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 221 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 222 Biotechnology biotechnology NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 223 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 224 sc-48402 sc-48402 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 225 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 226 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 227 rabbit rabbit NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 228 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 229 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 230 LC3 lc3 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 231 polyclonal polyclonal NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 232 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 233 Novus Novus NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 234 Biologics Biologics NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 235 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 236 100 100 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 237 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 326 238 2331 2331 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 239 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 240 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 241 mouse mouse NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 242 anti anti AFX work_zbi2knhp65ho5n7vbsuthmd7gi 326 243 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 244 HSPA1A hspa1a JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 245 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 326 246 Hsp70 Hsp70 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 247 monoclo- monoclo- NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 248 nal nal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 249 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 250 Enzo Enzo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 251 Life Life NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 252 Sciences Sciences NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 326 253 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 254 SPA-810-F SPA-810-F NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 255 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 256 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 257 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 258 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 259 HSP90AA1 hsp90aa1 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 326 260 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 326 261 Hsp90 Hsp90 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 262 monoclonal monoclonal NN work_zbi2knhp65ho5n7vbsuthmd7gi 326 263 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 264 Enzo Enzo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 265 Life Life NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 266 Sciences Sciences NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 326 267 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 268 SPA-836-D SPA-836-D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 269 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 270 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 326 271 mouse mouse NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 272 anti- anti- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 273 amodiaquine amodiaquine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 274 monoclonal monoclonal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 275 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 276 Thermo Thermo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 277 Scientific Scientific NNP work_zbi2knhp65ho5n7vbsuthmd7gi 326 278 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 326 279 320 320 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 280 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 326 281 04 04 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 282 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 326 283 02 02 CD work_zbi2knhp65ho5n7vbsuthmd7gi 326 284 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 326 285 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 327 1 Use Use NNP work_zbi2knhp65ho5n7vbsuthmd7gi 327 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 327 3 HRP HRP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 327 4 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 327 5 conjugated conjugate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 327 6 goat goat NN work_zbi2knhp65ho5n7vbsuthmd7gi 327 7 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 327 8 - - NN work_zbi2knhp65ho5n7vbsuthmd7gi 327 9 rabbit rabbit JJ work_zbi2knhp65ho5n7vbsuthmd7gi 327 10 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 327 11 Jackson Jackson NNP work_zbi2knhp65ho5n7vbsuthmd7gi 327 12 Immunological Immunological NNP work_zbi2knhp65ho5n7vbsuthmd7gi 327 13 Research Research NNP work_zbi2knhp65ho5n7vbsuthmd7gi 327 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 327 15 111 111 CD work_zbi2knhp65ho5n7vbsuthmd7gi 327 16 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 327 17 035 035 CD work_zbi2knhp65ho5n7vbsuthmd7gi 327 18 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 327 19 144 144 CD work_zbi2knhp65ho5n7vbsuthmd7gi 327 20 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 327 21 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 327 22 goat goat NN work_zbi2knhp65ho5n7vbsuthmd7gi 327 23 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 327 24 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 327 25 mouse mouse JJ work_zbi2knhp65ho5n7vbsuthmd7gi 327 26 secondary secondary JJ work_zbi2knhp65ho5n7vbsuthmd7gi 327 27 antibody antibody NN work_zbi2knhp65ho5n7vbsuthmd7gi 327 28 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 327 29 Jackson Jackson NNP work_zbi2knhp65ho5n7vbsuthmd7gi 327 30 Immunological Immunological NNP work_zbi2knhp65ho5n7vbsuthmd7gi 327 31 Research Research NNP work_zbi2knhp65ho5n7vbsuthmd7gi 327 32 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 327 33 115 115 CD work_zbi2knhp65ho5n7vbsuthmd7gi 327 34 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 327 35 035 035 CD work_zbi2knhp65ho5n7vbsuthmd7gi 327 36 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 327 37 146 146 CD work_zbi2knhp65ho5n7vbsuthmd7gi 327 38 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 327 39 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 327 40 followed follow VBN work_zbi2knhp65ho5n7vbsuthmd7gi 327 41 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 327 42 visualization visualization NN work_zbi2knhp65ho5n7vbsuthmd7gi 327 43 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 327 44 enhanced enhanced JJ work_zbi2knhp65ho5n7vbsuthmd7gi 327 45 chemiluminescence chemiluminescence NN work_zbi2knhp65ho5n7vbsuthmd7gi 327 46 detection detection NN work_zbi2knhp65ho5n7vbsuthmd7gi 327 47 reagents reagent NNS work_zbi2knhp65ho5n7vbsuthmd7gi 327 48 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 328 1 Equal equal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 328 2 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 328 3 loading loading NN work_zbi2knhp65ho5n7vbsuthmd7gi 328 4 was be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 328 5 examined examine VBN work_zbi2knhp65ho5n7vbsuthmd7gi 328 6 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 328 7 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 328 8 mouse mouse NN work_zbi2knhp65ho5n7vbsuthmd7gi 328 9 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 328 10 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 328 11 ACTB actb JJ work_zbi2knhp65ho5n7vbsuthmd7gi 328 12 monoclonal monoclonal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 328 13 antibody antibody NN work_zbi2knhp65ho5n7vbsuthmd7gi 328 14 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 328 15 Sigma Sigma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 328 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 328 17 A4700 A4700 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 328 18 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 328 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 329 1 Statistical statistical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 329 2 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 329 3 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 329 4 results result NNS work_zbi2knhp65ho5n7vbsuthmd7gi 329 5 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 329 6 presented present VBN work_zbi2knhp65ho5n7vbsuthmd7gi 329 7 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 329 8 means mean NNS work_zbi2knhp65ho5n7vbsuthmd7gi 329 9 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 329 10 ± ± NNP work_zbi2knhp65ho5n7vbsuthmd7gi 329 11 S.D. S.D. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 329 12 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 330 1 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 330 2 at at RB work_zbi2knhp65ho5n7vbsuthmd7gi 330 3 least least RBS work_zbi2knhp65ho5n7vbsuthmd7gi 330 4 three three CD work_zbi2knhp65ho5n7vbsuthmd7gi 330 5 independent independent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 330 6 experiments experiment NNS work_zbi2knhp65ho5n7vbsuthmd7gi 330 7 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 331 1 Data datum NNS work_zbi2knhp65ho5n7vbsuthmd7gi 331 2 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 331 3 analyzed analyze VBN work_zbi2knhp65ho5n7vbsuthmd7gi 331 4 employing employ VBG work_zbi2knhp65ho5n7vbsuthmd7gi 331 5 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 331 6 two two CD work_zbi2knhp65ho5n7vbsuthmd7gi 331 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 331 8 sided sided JJ work_zbi2knhp65ho5n7vbsuthmd7gi 331 9 Student student NN work_zbi2knhp65ho5n7vbsuthmd7gi 331 10 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 331 11 test test NN work_zbi2knhp65ho5n7vbsuthmd7gi 331 12 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 331 13 differences difference NNS work_zbi2knhp65ho5n7vbsuthmd7gi 331 14 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 331 15 considered consider VBN work_zbi2knhp65ho5n7vbsuthmd7gi 331 16 signifi- signifi- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 331 17 ca can MD work_zbi2knhp65ho5n7vbsuthmd7gi 331 18 nt not RB work_zbi2knhp65ho5n7vbsuthmd7gi 331 19 at at IN work_zbi2knhp65ho5n7vbsuthmd7gi 331 20 P p NN work_zbi2knhp65ho5n7vbsuthmd7gi 331 21 < < XX work_zbi2knhp65ho5n7vbsuthmd7gi 331 22 0.05 0.05 CD work_zbi2knhp65ho5n7vbsuthmd7gi 331 23 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 331 24 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 331 25 P p NN work_zbi2knhp65ho5n7vbsuthmd7gi 331 26 < < XX work_zbi2knhp65ho5n7vbsuthmd7gi 331 27 0.05 0.05 XX work_zbi2knhp65ho5n7vbsuthmd7gi 331 28 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 331 29 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 331 30 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 331 31 P p NN work_zbi2knhp65ho5n7vbsuthmd7gi 331 32 < < XX work_zbi2knhp65ho5n7vbsuthmd7gi 331 33 0.01 0.01 XX work_zbi2knhp65ho5n7vbsuthmd7gi 331 34 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 331 35 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 331 36 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 331 37 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 331 38 P p NN work_zbi2knhp65ho5n7vbsuthmd7gi 331 39 < < XX work_zbi2knhp65ho5n7vbsuthmd7gi 331 40 0.001 0.001 CD work_zbi2knhp65ho5n7vbsuthmd7gi 331 41 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 331 42 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 332 1 Selected select VBN work_zbi2knhp65ho5n7vbsuthmd7gi 332 2 data data NN work_zbi2knhp65ho5n7vbsuthmd7gi 332 3 sets set NNS work_zbi2knhp65ho5n7vbsuthmd7gi 332 4 were be VBD work_zbi2knhp65ho5n7vbsuthmd7gi 332 5 analyzed analyze VBN work_zbi2knhp65ho5n7vbsuthmd7gi 332 6 employing employ VBG work_zbi2knhp65ho5n7vbsuthmd7gi 332 7 one one CD work_zbi2knhp65ho5n7vbsuthmd7gi 332 8 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 332 9 way way NN work_zbi2knhp65ho5n7vbsuthmd7gi 332 10 analysis analysis NN work_zbi2knhp65ho5n7vbsuthmd7gi 332 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 332 12 variance variance NN work_zbi2knhp65ho5n7vbsuthmd7gi 332 13 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 332 14 ANOVA ANOVA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 332 15 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 332 16 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 332 17 Tukey Tukey NNP work_zbi2knhp65ho5n7vbsuthmd7gi 332 18 ’s ’s POS work_zbi2knhp65ho5n7vbsuthmd7gi 332 19 post post FW work_zbi2knhp65ho5n7vbsuthmd7gi 332 20 hoc hoc FW work_zbi2knhp65ho5n7vbsuthmd7gi 332 21 test test NN work_zbi2knhp65ho5n7vbsuthmd7gi 332 22 using use VBG work_zbi2knhp65ho5n7vbsuthmd7gi 332 23 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 332 24 PRISM PRISM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 332 25 4.0 4.0 CD work_zbi2knhp65ho5n7vbsuthmd7gi 332 26 software software NN work_zbi2knhp65ho5n7vbsuthmd7gi 332 27 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 332 28 means mean VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 332 29 without without IN work_zbi2knhp65ho5n7vbsuthmd7gi 332 30 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 332 31 common common JJ work_zbi2knhp65ho5n7vbsuthmd7gi 332 32 letter letter NN work_zbi2knhp65ho5n7vbsuthmd7gi 332 33 differ differ VBP work_zbi2knhp65ho5n7vbsuthmd7gi 332 34 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 332 35 each each DT work_zbi2knhp65ho5n7vbsuthmd7gi 332 36 other other JJ work_zbi2knhp65ho5n7vbsuthmd7gi 332 37 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 332 38 P p NN work_zbi2knhp65ho5n7vbsuthmd7gi 332 39 < < XX work_zbi2knhp65ho5n7vbsuthmd7gi 332 40 0.05 0.05 CD work_zbi2knhp65ho5n7vbsuthmd7gi 332 41 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 332 42 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 333 1 Disclosure disclosure NN work_zbi2knhp65ho5n7vbsuthmd7gi 333 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 333 3 Potential potential JJ work_zbi2knhp65ho5n7vbsuthmd7gi 333 4 Conflicts Conflicts NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 333 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 333 6 Interest interest NN work_zbi2knhp65ho5n7vbsuthmd7gi 333 7 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 333 8 authors author NNS work_zbi2knhp65ho5n7vbsuthmd7gi 333 9 have have VBP work_zbi2knhp65ho5n7vbsuthmd7gi 333 10 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 333 11 conflicts conflict NNS work_zbi2knhp65ho5n7vbsuthmd7gi 333 12 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 333 13 interest interest NN work_zbi2knhp65ho5n7vbsuthmd7gi 333 14 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 333 15 declare declare VB work_zbi2knhp65ho5n7vbsuthmd7gi 333 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 334 1 There there EX work_zbi2knhp65ho5n7vbsuthmd7gi 334 2 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 334 3 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 334 4 financial financial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 334 5 disclosures disclosure NNS work_zbi2knhp65ho5n7vbsuthmd7gi 334 6 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 334 7 be be VB work_zbi2knhp65ho5n7vbsuthmd7gi 334 8 made make VBN work_zbi2knhp65ho5n7vbsuthmd7gi 334 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 335 1 Acknowledgments acknowledgment NNS work_zbi2knhp65ho5n7vbsuthmd7gi 335 2 Supported support VBN work_zbi2knhp65ho5n7vbsuthmd7gi 335 3 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 335 4 part part NN work_zbi2knhp65ho5n7vbsuthmd7gi 335 5 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 335 6 grants grant NNS work_zbi2knhp65ho5n7vbsuthmd7gi 335 7 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 335 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 335 9 National National NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 10 Institutes Institutes NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 335 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 335 12 Health Health NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 13 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 335 14 R01CA122484 R01CA122484 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 335 16 R03CA167580 R03CA167580 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 335 18 R21CA166926 R21CA166926 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 19 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 335 20 ES007091 ES007091 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 335 22 ES06694 ES06694 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 335 24 Arizona Arizona NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 25 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 26 Center Center NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 27 Support Support NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 28 Grant Grant NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 29 CA023074 CA023074 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 335 30 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 335 31 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 336 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 336 2 content content NN work_zbi2knhp65ho5n7vbsuthmd7gi 336 3 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 336 4 solely solely RB work_zbi2knhp65ho5n7vbsuthmd7gi 336 5 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 336 6 responsibility responsibility NN work_zbi2knhp65ho5n7vbsuthmd7gi 336 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 336 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 336 9 authors author NNS work_zbi2knhp65ho5n7vbsuthmd7gi 336 10 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 336 11 does do VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 336 12 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 336 13 necessarily necessarily RB work_zbi2knhp65ho5n7vbsuthmd7gi 336 14 represent represent VB work_zbi2knhp65ho5n7vbsuthmd7gi 336 15 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 336 16 official official JJ work_zbi2knhp65ho5n7vbsuthmd7gi 336 17 views view NNS work_zbi2knhp65ho5n7vbsuthmd7gi 336 18 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 336 19 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 336 20 National National NNP work_zbi2knhp65ho5n7vbsuthmd7gi 336 21 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 336 22 Institute Institute NNP work_zbi2knhp65ho5n7vbsuthmd7gi 336 23 or or CC work_zbi2knhp65ho5n7vbsuthmd7gi 336 24 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 336 25 National National NNP work_zbi2knhp65ho5n7vbsuthmd7gi 336 26 Institutes Institutes NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 336 27 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 336 28 Health Health NNP work_zbi2knhp65ho5n7vbsuthmd7gi 336 29 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 337 1 References reference NNS work_zbi2knhp65ho5n7vbsuthmd7gi 337 2 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 337 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 338 1 Klionsky Klionsky NNP work_zbi2knhp65ho5n7vbsuthmd7gi 338 2 DJ DJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 338 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 339 1 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 339 2 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 339 3 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 339 4 phenomenology phenomenology NN work_zbi2knhp65ho5n7vbsuthmd7gi 339 5 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 339 6 molecular molecular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 339 7 understanding understanding NN work_zbi2knhp65ho5n7vbsuthmd7gi 339 8 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 339 9 less less JJR work_zbi2knhp65ho5n7vbsuthmd7gi 339 10 than than IN work_zbi2knhp65ho5n7vbsuthmd7gi 339 11 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 339 12 decade decade NN work_zbi2knhp65ho5n7vbsuthmd7gi 339 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 340 1 Nat Nat NNP work_zbi2knhp65ho5n7vbsuthmd7gi 340 2 Rev Rev NNP work_zbi2knhp65ho5n7vbsuthmd7gi 340 3 Mol Mol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 340 4 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 340 5 Biol Biol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 340 6 2007 2007 CD work_zbi2knhp65ho5n7vbsuthmd7gi 340 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 340 8 8:931 8:931 CD work_zbi2knhp65ho5n7vbsuthmd7gi 340 9 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 340 10 7 7 CD work_zbi2knhp65ho5n7vbsuthmd7gi 340 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 340 12 PMID:17712358 pmid:17712358 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 340 13 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 340 14 http://dx.doi.org/10.1038/nrm2245 http://dx.doi.org/10.1038/nrm2245 NN work_zbi2knhp65ho5n7vbsuthmd7gi 340 15 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 340 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 341 1 Mizushima Mizushima NNP work_zbi2knhp65ho5n7vbsuthmd7gi 341 2 N N NNP work_zbi2knhp65ho5n7vbsuthmd7gi 341 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 341 4 Levine Levine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 341 5 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 341 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 341 7 Cuervo Cuervo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 341 8 AM am VBP work_zbi2knhp65ho5n7vbsuthmd7gi 341 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 341 10 Klionsky Klionsky NNP work_zbi2knhp65ho5n7vbsuthmd7gi 341 11 DJ DJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 341 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 342 1 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 342 2 fights fight VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 342 3 disease disease NN work_zbi2knhp65ho5n7vbsuthmd7gi 342 4 through through IN work_zbi2knhp65ho5n7vbsuthmd7gi 342 5 cellular cellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 342 6 self self NN work_zbi2knhp65ho5n7vbsuthmd7gi 342 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 342 8 diges- diges- NNS work_zbi2knhp65ho5n7vbsuthmd7gi 342 9 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 342 10 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 343 1 Nature nature NN work_zbi2knhp65ho5n7vbsuthmd7gi 343 2 2008 2008 CD work_zbi2knhp65ho5n7vbsuthmd7gi 343 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 343 4 451:1069 451:1069 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 343 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 343 6 75 75 CD work_zbi2knhp65ho5n7vbsuthmd7gi 343 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 343 8 PMID:18305538 PMID:18305538 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 343 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 343 10 http://dx.doi.org/10.1038/nature06639 http://dx.doi.org/10.1038/nature06639 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 343 11 3 3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 343 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 344 1 Cecconi Cecconi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 344 2 F F NNP work_zbi2knhp65ho5n7vbsuthmd7gi 344 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 344 4 Levine Levine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 344 5 B. B. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 345 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 345 2 role role NN work_zbi2knhp65ho5n7vbsuthmd7gi 345 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 345 4 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 345 5 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 345 6 mam- mam- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 345 7 malian malian JJ work_zbi2knhp65ho5n7vbsuthmd7gi 345 8 development development NN work_zbi2knhp65ho5n7vbsuthmd7gi 345 9 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 345 10 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 345 11 makeover makeover NN work_zbi2knhp65ho5n7vbsuthmd7gi 345 12 rather rather RB work_zbi2knhp65ho5n7vbsuthmd7gi 345 13 than than IN work_zbi2knhp65ho5n7vbsuthmd7gi 345 14 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 345 15 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 345 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 346 1 Dev Dev NNP work_zbi2knhp65ho5n7vbsuthmd7gi 346 2 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 346 3 2008 2008 CD work_zbi2knhp65ho5n7vbsuthmd7gi 346 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 346 5 15:344 15:344 CD work_zbi2knhp65ho5n7vbsuthmd7gi 346 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 346 7 57 57 CD work_zbi2knhp65ho5n7vbsuthmd7gi 346 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 346 9 PMID:18804433 PMID:18804433 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 346 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 346 11 http://dx.doi.org/10.1016/j.devcel.2008.08.012 http://dx.doi.org/10.1016/j.devcel.2008.08.012 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 346 12 4 4 CD work_zbi2knhp65ho5n7vbsuthmd7gi 346 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 347 1 Rubinsztein Rubinsztein NNP work_zbi2knhp65ho5n7vbsuthmd7gi 347 2 DC DC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 347 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 347 4 Codogno Codogno NNP work_zbi2knhp65ho5n7vbsuthmd7gi 347 5 P P NNP work_zbi2knhp65ho5n7vbsuthmd7gi 347 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 347 7 Levine Levine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 347 8 B. B. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 347 9 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 347 10 modulation modulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 347 11 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 347 12 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 347 13 potential potential JJ work_zbi2knhp65ho5n7vbsuthmd7gi 347 14 therapeutic therapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 347 15 target target NN work_zbi2knhp65ho5n7vbsuthmd7gi 347 16 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 347 17 diverse diverse JJ work_zbi2knhp65ho5n7vbsuthmd7gi 347 18 diseases disease NNS work_zbi2knhp65ho5n7vbsuthmd7gi 347 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 348 1 Nat Nat NNP work_zbi2knhp65ho5n7vbsuthmd7gi 348 2 Rev Rev NNP work_zbi2knhp65ho5n7vbsuthmd7gi 348 3 Drug Drug NNP work_zbi2knhp65ho5n7vbsuthmd7gi 348 4 Discov Discov NNP work_zbi2knhp65ho5n7vbsuthmd7gi 348 5 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 348 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 348 7 11:709- 11:709- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 348 8 30 30 CD work_zbi2knhp65ho5n7vbsuthmd7gi 348 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 348 10 PMID:22935804 PMID:22935804 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 348 11 ; ; , work_zbi2knhp65ho5n7vbsuthmd7gi 348 12 http://dx.doi.org/10.1038/ http://dx.doi.org/10.1038/ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 348 13 nrd3802 nrd3802 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 348 14 5 5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 348 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 349 1 Benbrook Benbrook NNP work_zbi2knhp65ho5n7vbsuthmd7gi 349 2 DM DM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 349 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 349 4 Long Long NNP work_zbi2knhp65ho5n7vbsuthmd7gi 349 5 A. A. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 350 1 Integration integration NN work_zbi2knhp65ho5n7vbsuthmd7gi 350 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 350 3 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 350 4 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 350 5 proteasomal proteasomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 350 6 degradation degradation NN work_zbi2knhp65ho5n7vbsuthmd7gi 350 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 350 8 unfolded unfolded JJ work_zbi2knhp65ho5n7vbsuthmd7gi 350 9 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 350 10 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 350 11 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 350 12 apoptosis apoptosis NN work_zbi2knhp65ho5n7vbsuthmd7gi 350 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 351 1 Exp Exp NNP work_zbi2knhp65ho5n7vbsuthmd7gi 351 2 Oncol Oncol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 351 3 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 351 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 351 5 34:286 34:286 CD work_zbi2knhp65ho5n7vbsuthmd7gi 351 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 351 7 97 97 CD work_zbi2knhp65ho5n7vbsuthmd7gi 351 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 351 9 PMID:23070014 PMID:23070014 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 351 10 6 6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 351 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 352 1 Lau Lau NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 2 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 352 4 Zheng Zheng NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 5 Y Y NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 352 7 Tao Tao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 8 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 352 10 Wang Wang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 11 H H NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 352 13 Whitman Whitman NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 14 SA SA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 352 16 White White NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 17 E E NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 352 19 Zhang Zhang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 20 DD DD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 352 21 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 353 1 Arsenic arsenic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 353 2 inhibits inhibit VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 353 3 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 353 4 f f NNP work_zbi2knhp65ho5n7vbsuthmd7gi 353 5 lux lux NNP work_zbi2knhp65ho5n7vbsuthmd7gi 353 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 353 7 activating activate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 353 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 353 9 Nrf2-Keap1 Nrf2-Keap1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 353 10 pathway pathway NN work_zbi2knhp65ho5n7vbsuthmd7gi 353 11 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 353 12 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 353 13 p62-depen- p62-depen- NN work_zbi2knhp65ho5n7vbsuthmd7gi 353 14 dent dent NN work_zbi2knhp65ho5n7vbsuthmd7gi 353 15 manner manner NN work_zbi2knhp65ho5n7vbsuthmd7gi 353 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 354 1 Mol Mol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 354 2 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 354 3 Biol Biol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 354 4 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 354 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 354 6 33:2436 33:2436 CD work_zbi2knhp65ho5n7vbsuthmd7gi 354 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 354 8 46 46 CD work_zbi2knhp65ho5n7vbsuthmd7gi 354 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 354 10 PMID:23589329 pmid:23589329 NN work_zbi2knhp65ho5n7vbsuthmd7gi 354 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 354 12 http://dx.doi.org/10.1128/ http://dx.doi.org/10.1128/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 354 13 MCB.01748 MCB.01748 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 354 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 354 15 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 354 16 7 7 CD work_zbi2knhp65ho5n7vbsuthmd7gi 354 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 355 1 Lamore Lamore NNP work_zbi2knhp65ho5n7vbsuthmd7gi 355 2 SD SD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 355 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 355 4 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 355 5 GT GT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 355 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 356 1 Autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 356 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 356 3 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 356 4 dys- dys- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 356 5 regulation regulation NNP work_zbi2knhp65ho5n7vbsuthmd7gi 356 6 downstream downstream NNP work_zbi2knhp65ho5n7vbsuthmd7gi 356 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 356 8 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 356 9 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 356 10 inactivation inactivation NN work_zbi2knhp65ho5n7vbsuthmd7gi 356 11 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 356 12 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 356 13 skin skin NN work_zbi2knhp65ho5n7vbsuthmd7gi 356 14 fibroblasts fibroblast NNS work_zbi2knhp65ho5n7vbsuthmd7gi 356 15 exposed expose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 356 16 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 356 17 UVA UVA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 356 18 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 357 1 Photochem Photochem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 357 2 Photobiol Photobiol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 357 3 Sci Sci NNP work_zbi2knhp65ho5n7vbsuthmd7gi 357 4 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 357 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 357 6 11:163 11:163 CD work_zbi2knhp65ho5n7vbsuthmd7gi 357 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 357 8 72 72 CD work_zbi2knhp65ho5n7vbsuthmd7gi 357 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 357 10 PMID:21773629 PMID:21773629 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 357 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 357 12 http://dx.doi.org/10.1039/c1pp05131h http://dx.doi.org/10.1039/c1pp05131h ADD work_zbi2knhp65ho5n7vbsuthmd7gi 357 13 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 357 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 358 1 Lamore Lamore NNP work_zbi2knhp65ho5n7vbsuthmd7gi 358 2 SD SD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 358 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 358 4 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 358 5 GT GT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 358 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 359 1 UVA UVA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 359 2 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 359 3 dual dual JJ work_zbi2knhp65ho5n7vbsuthmd7gi 359 4 inactiva- inactiva- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 359 5 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 359 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 359 7 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 359 8 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 359 9 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 359 10 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 359 11 underlying underlie VBG work_zbi2knhp65ho5n7vbsuthmd7gi 359 12 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 359 13 dys- dys- NN work_zbi2knhp65ho5n7vbsuthmd7gi 359 14 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 359 15 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 359 16 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 359 17 dermal dermal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 359 18 fibroblasts fibroblast NNS work_zbi2knhp65ho5n7vbsuthmd7gi 359 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 360 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 360 2 Photochem Photochem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 360 3 Photobiol Photobiol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 360 4 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 360 5 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 360 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 360 7 123:1 123:1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 360 8 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 360 9 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 360 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 360 11 PMID:23603447 PMID:23603447 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 360 12 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 360 13 http://dx.doi.org/10.1016/j.jphotobiol.2013.03.007 http://dx.doi.org/10.1016/j.jphotobiol.2013.03.007 CC work_zbi2knhp65ho5n7vbsuthmd7gi 360 14 9 9 CD work_zbi2knhp65ho5n7vbsuthmd7gi 360 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 361 1 Amaravadi Amaravadi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 2 RK RK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 361 4 Lippincott Lippincott NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 361 6 Schwartz Schwartz NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 7 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 8 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 361 9 Yin Yin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 10 XM XM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 11 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 361 12 Weiss Weiss NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 13 WA WA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 361 15 Takebe Takebe NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 16 N N NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 361 18 Timmer Timmer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 19 W W NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 361 21 DiPaola DiPaola NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 22 RS RS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 361 24 Lotze Lotze NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 25 MT MT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 361 27 White White NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 28 E. E. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 29 Principles Principles NNP work_zbi2knhp65ho5n7vbsuthmd7gi 361 30 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 361 31 current current JJ work_zbi2knhp65ho5n7vbsuthmd7gi 361 32 strate- strate- NNS work_zbi2knhp65ho5n7vbsuthmd7gi 361 33 gies gy NNS work_zbi2knhp65ho5n7vbsuthmd7gi 361 34 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 361 35 targeting target VBG work_zbi2knhp65ho5n7vbsuthmd7gi 361 36 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 361 37 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 361 38 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 361 39 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 361 40 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 362 1 Clin Clin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 362 2 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 362 3 Res Res NNP work_zbi2knhp65ho5n7vbsuthmd7gi 362 4 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 362 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 362 6 17:654 17:654 CD work_zbi2knhp65ho5n7vbsuthmd7gi 362 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 362 8 66 66 CD work_zbi2knhp65ho5n7vbsuthmd7gi 362 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 362 10 PMID:21325294 PMID:21325294 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 362 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 362 12 http://dx.doi.org/10.1158/1078-0432.CCR-10-2634 http://dx.doi.org/10.1158/1078-0432.ccr-10-2634 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 362 13 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 362 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 363 1 Sheen Sheen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 363 2 JH JH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 363 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 363 4 Zoncu Zoncu NNP work_zbi2knhp65ho5n7vbsuthmd7gi 363 5 R R NNP work_zbi2knhp65ho5n7vbsuthmd7gi 363 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 363 7 Kim Kim NNP work_zbi2knhp65ho5n7vbsuthmd7gi 363 8 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 363 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 363 10 Sabatini Sabatini NNP work_zbi2knhp65ho5n7vbsuthmd7gi 363 11 DM DM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 363 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 364 1 Defective defective JJ work_zbi2knhp65ho5n7vbsuthmd7gi 364 2 regulation regulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 364 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 364 4 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 364 5 upon upon IN work_zbi2knhp65ho5n7vbsuthmd7gi 364 6 leucine leucine JJ work_zbi2knhp65ho5n7vbsuthmd7gi 364 7 deprivation deprivation NN work_zbi2knhp65ho5n7vbsuthmd7gi 364 8 reveals reveal VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 364 9 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 364 10 targetable targetable JJ work_zbi2knhp65ho5n7vbsuthmd7gi 364 11 liability liability NN work_zbi2knhp65ho5n7vbsuthmd7gi 364 12 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 364 13 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 364 14 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 364 15 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 364 16 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 364 17 vitro vitro NNP work_zbi2knhp65ho5n7vbsuthmd7gi 364 18 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 364 19 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 364 20 vivo vivo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 364 21 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 365 1 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 365 2 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 365 3 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 365 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 365 5 19:613- 19:613- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 365 6 28 28 CD work_zbi2knhp65ho5n7vbsuthmd7gi 365 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 365 8 PMID:21575862 PMID:21575862 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 365 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 365 10 http://dx.doi.org/10.1016/j http://dx.doi.org/10.1016/j NNP work_zbi2knhp65ho5n7vbsuthmd7gi 365 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 366 1 ccr.2011.03.012 ccr.2011.03.012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 366 2 11 11 CD work_zbi2knhp65ho5n7vbsuthmd7gi 366 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 367 1 Yu Yu NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 2 H H NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 367 4 Su Su NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 5 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 367 7 Xu Xu NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 8 Y Y NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 367 10 Kang Kang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 11 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 367 13 Li Li NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 14 H H NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 367 16 Zhang Zhang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 17 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 367 19 Yi Yi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 20 H H NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 367 22 Xiang Xiang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 23 X X NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 367 25 Liu Liu NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 26 F F NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 27 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 367 28 Sun Sun NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 29 L. L. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 367 30 p62 p62 NN work_zbi2knhp65ho5n7vbsuthmd7gi 367 31 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 367 32 SQSTM1 SQSTM1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 367 33 involved involve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 367 34 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 367 35 cisplatin cisplatin NN work_zbi2knhp65ho5n7vbsuthmd7gi 367 36 resistance resistance NN work_zbi2knhp65ho5n7vbsuthmd7gi 367 37 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 367 38 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 367 39 ovarian ovarian JJ work_zbi2knhp65ho5n7vbsuthmd7gi 367 40 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 367 41 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 367 42 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 367 43 clearing clear VBG work_zbi2knhp65ho5n7vbsuthmd7gi 367 44 ubiquitinated ubiquitinated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 367 45 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 367 46 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 368 1 Eur Eur NNP work_zbi2knhp65ho5n7vbsuthmd7gi 368 2 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 368 3 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 368 4 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 368 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 368 6 47:1585- 47:1585- CD work_zbi2knhp65ho5n7vbsuthmd7gi 368 7 94 94 CD work_zbi2knhp65ho5n7vbsuthmd7gi 368 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 368 9 PMID:21371883 pmid:21371883 NN work_zbi2knhp65ho5n7vbsuthmd7gi 368 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 368 11 http://dx.doi.org/10.1016/j http://dx.doi.org/10.1016/j NNP work_zbi2knhp65ho5n7vbsuthmd7gi 368 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 369 1 ejca.2011.01.019 ejca.2011.01.019 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 369 2 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 369 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 370 1 O’Donovan O’Donovan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 370 2 TR TR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 370 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 370 4 O’Sullivan O’Sullivan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 370 5 GC GC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 370 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 370 7 McKenna McKenna NNP work_zbi2knhp65ho5n7vbsuthmd7gi 370 8 SL SL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 370 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 371 1 Induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 371 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 371 3 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 371 4 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 371 5 drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 371 6 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 371 7 resistant resistant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 371 8 esopha- esopha- FW work_zbi2knhp65ho5n7vbsuthmd7gi 371 9 geal geal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 371 10 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 371 11 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 371 12 promotes promote VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 371 13 their -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 371 14 survival survival NN work_zbi2knhp65ho5n7vbsuthmd7gi 371 15 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 371 16 recov- recov- NN work_zbi2knhp65ho5n7vbsuthmd7gi 371 17 ery ery NN work_zbi2knhp65ho5n7vbsuthmd7gi 371 18 following follow VBG work_zbi2knhp65ho5n7vbsuthmd7gi 371 19 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 371 20 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 371 21 chemotherapeutics chemotherapeutic NNS work_zbi2knhp65ho5n7vbsuthmd7gi 371 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 372 1 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 372 2 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 372 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 372 4 7:509 7:509 CD work_zbi2knhp65ho5n7vbsuthmd7gi 372 5 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 372 6 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 372 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 372 8 PMID:21325880 pmid:21325880 NN work_zbi2knhp65ho5n7vbsuthmd7gi 372 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 372 10 http://dx.doi.org/10.4161/auto.7.5.15066 http://dx.doi.org/10.4161/auto.7.5.15066 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 372 11 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 372 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 373 1 Amaravadi Amaravadi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 2 RK RK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 373 4 Yu Yu NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 5 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 373 7 Lum Lum NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 8 JJ JJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 373 10 Bui Bui NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 11 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 373 13 Christophorou Christophorou NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 14 MA MA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 373 16 Evan Evan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 17 GI GI NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 373 19 Thomas Thomas NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 20 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 373 21 Tikhonenko Tikhonenko NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 22 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 373 24 Thompson Thompson NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 25 CB CB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 373 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 374 1 Autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 374 2 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 374 3 enhances enhance VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 374 4 therapy therapy NN work_zbi2knhp65ho5n7vbsuthmd7gi 374 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 374 6 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 374 7 apoptosis apoptosis NN work_zbi2knhp65ho5n7vbsuthmd7gi 374 8 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 374 9 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 374 10 Myc Myc NNP work_zbi2knhp65ho5n7vbsuthmd7gi 374 11 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 374 12 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 374 13 model model NN work_zbi2knhp65ho5n7vbsuthmd7gi 374 14 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 374 15 lymphoma lymphoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 374 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 375 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 375 2 Clin Clin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 375 3 Invest Invest NNP work_zbi2knhp65ho5n7vbsuthmd7gi 375 4 2007 2007 CD work_zbi2knhp65ho5n7vbsuthmd7gi 375 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 375 6 117:326 117:326 CD work_zbi2knhp65ho5n7vbsuthmd7gi 375 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 375 8 36 36 CD work_zbi2knhp65ho5n7vbsuthmd7gi 375 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 375 10 PMID:17235397 PMID:17235397 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 375 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 375 12 http://dx.doi.org/10.1172/JCI28833 http://dx.doi.org/10.1172/jci28833 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 375 13 14 14 CD work_zbi2knhp65ho5n7vbsuthmd7gi 375 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 376 1 Degtyarev Degtyarev NNP work_zbi2knhp65ho5n7vbsuthmd7gi 376 2 M M NNP work_zbi2knhp65ho5n7vbsuthmd7gi 376 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 376 4 De De NNP work_zbi2knhp65ho5n7vbsuthmd7gi 376 5 Mazière Mazière NNP work_zbi2knhp65ho5n7vbsuthmd7gi 376 6 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 376 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 376 8 Klumperman Klumperman NNP work_zbi2knhp65ho5n7vbsuthmd7gi 376 9 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 376 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 376 11 Lin Lin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 376 12 K. K. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 376 13 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 376 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 376 15 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 376 16 Achilles Achilles NNP work_zbi2knhp65ho5n7vbsuthmd7gi 376 17 ’ ’ POS work_zbi2knhp65ho5n7vbsuthmd7gi 376 18 heel heel NN work_zbi2knhp65ho5n7vbsuthmd7gi 376 19 AKTing akte VBG work_zbi2knhp65ho5n7vbsuthmd7gi 376 20 against against IN work_zbi2knhp65ho5n7vbsuthmd7gi 376 21 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 376 22 ? ? . work_zbi2knhp65ho5n7vbsuthmd7gi 377 1 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 377 2 2009 2009 CD work_zbi2knhp65ho5n7vbsuthmd7gi 377 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 377 4 5:415 5:415 CD work_zbi2knhp65ho5n7vbsuthmd7gi 377 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 377 6 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 377 7 ; ; , work_zbi2knhp65ho5n7vbsuthmd7gi 377 8 PMID:19305139 pmid:19305139 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 377 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 377 10 http:// http:// NN work_zbi2knhp65ho5n7vbsuthmd7gi 377 11 dx.doi.org/10.4161/auto.5.3.7827 dx.doi.org/10.4161/auto.5.3.7827 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 377 12 15 15 CD work_zbi2knhp65ho5n7vbsuthmd7gi 377 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 378 1 Xie Xie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 378 2 X X NNP work_zbi2knhp65ho5n7vbsuthmd7gi 378 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 378 4 White White NNP work_zbi2knhp65ho5n7vbsuthmd7gi 378 5 EP EP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 378 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 378 7 Mehnert Mehnert NNP work_zbi2knhp65ho5n7vbsuthmd7gi 378 8 JM JM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 378 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 379 1 Coordinate coordinate VB work_zbi2knhp65ho5n7vbsuthmd7gi 379 2 auto- auto- NN work_zbi2knhp65ho5n7vbsuthmd7gi 379 3 phagy phagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 379 4 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 379 5 mTOR mTOR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 379 6 pathway pathway NNP work_zbi2knhp65ho5n7vbsuthmd7gi 379 7 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 379 8 enhances enhance VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 379 9 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 379 10 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 379 11 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 379 12 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 379 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 380 1 PLoS plos ADD work_zbi2knhp65ho5n7vbsuthmd7gi 380 2 One one CD work_zbi2knhp65ho5n7vbsuthmd7gi 380 3 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 380 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 380 5 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 380 6 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 380 7 e55096 e55096 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 380 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 380 9 PMID:23383069 PMID:23383069 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 380 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 380 11 http://dx.doi.org/10.1371/jour- http://dx.doi.org/10.1371/jour- . work_zbi2knhp65ho5n7vbsuthmd7gi 380 12 nal.pone.0055096 nal.pone.0055096 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 380 13 16 16 CD work_zbi2knhp65ho5n7vbsuthmd7gi 380 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 381 1 Reaume Reaume NNP work_zbi2knhp65ho5n7vbsuthmd7gi 381 2 AG AG NNP work_zbi2knhp65ho5n7vbsuthmd7gi 381 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 382 1 Drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 382 2 repurposing repurpose VBG work_zbi2knhp65ho5n7vbsuthmd7gi 382 3 through through IN work_zbi2knhp65ho5n7vbsuthmd7gi 382 4 nonhypoth- nonhypoth- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 382 5 esis esis NNP work_zbi2knhp65ho5n7vbsuthmd7gi 382 6 driven drive VBN work_zbi2knhp65ho5n7vbsuthmd7gi 382 7 phenotypic phenotypic NN work_zbi2knhp65ho5n7vbsuthmd7gi 382 8 screening screening NN work_zbi2knhp65ho5n7vbsuthmd7gi 382 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 383 1 Drug Drug NNP work_zbi2knhp65ho5n7vbsuthmd7gi 383 2 Discov Discov NNP work_zbi2knhp65ho5n7vbsuthmd7gi 383 3 Today today NN work_zbi2knhp65ho5n7vbsuthmd7gi 383 4 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 383 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 383 6 8:85 8:85 CD work_zbi2knhp65ho5n7vbsuthmd7gi 383 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 383 8 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 383 9 17 17 CD work_zbi2knhp65ho5n7vbsuthmd7gi 383 10 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 384 1 Weir Weir NNP work_zbi2knhp65ho5n7vbsuthmd7gi 384 2 SJ SJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 384 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 384 4 DeGennaro DeGennaro NNP work_zbi2knhp65ho5n7vbsuthmd7gi 384 5 LJ LJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 384 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 384 7 Austin Austin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 384 8 CP CP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 384 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 385 1 Repurposing repurpose VBG work_zbi2knhp65ho5n7vbsuthmd7gi 385 2 approved approve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 385 3 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 385 4 abandoned abandon VBN work_zbi2knhp65ho5n7vbsuthmd7gi 385 5 drugs drug NNS work_zbi2knhp65ho5n7vbsuthmd7gi 385 6 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 385 7 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 385 8 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 385 9 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 385 10 prevention prevention NN work_zbi2knhp65ho5n7vbsuthmd7gi 385 11 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 385 12 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 385 13 through through IN work_zbi2knhp65ho5n7vbsuthmd7gi 385 14 public public JJ work_zbi2knhp65ho5n7vbsuthmd7gi 385 15 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 385 16 private private JJ work_zbi2knhp65ho5n7vbsuthmd7gi 385 17 partner- partner- NN work_zbi2knhp65ho5n7vbsuthmd7gi 385 18 ship ship NN work_zbi2knhp65ho5n7vbsuthmd7gi 385 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 386 1 Cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 386 2 Res Res NNP work_zbi2knhp65ho5n7vbsuthmd7gi 386 3 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 386 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 386 5 72:1055 72:1055 CD work_zbi2knhp65ho5n7vbsuthmd7gi 386 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 386 7 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 386 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 386 9 PMID:22246671 PMID:22246671 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 386 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 386 11 http://dx.doi.org/10.1158/0008-5472.CAN-11-3439 http://dx.doi.org/10.1158/0008-5472.CAN-11-3439 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 386 12 18 18 CD work_zbi2knhp65ho5n7vbsuthmd7gi 386 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 387 1 Neznanov Neznanov NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 2 N N NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 387 4 Gorbachev Gorbachev NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 5 AV AV NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 387 7 Neznanova Neznanova NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 8 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 387 10 Komarov Komarov NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 11 AP AP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 387 13 Gurova Gurova NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 14 KV KV NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 387 16 Gasparian gasparian JJ work_zbi2knhp65ho5n7vbsuthmd7gi 387 17 AV AV NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 387 19 Banerjee Banerjee NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 20 AK AK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 387 22 Almasan Almasan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 23 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 387 25 Fairchild Fairchild NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 26 RL RL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 27 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 387 28 Gudkov Gudkov NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 29 AV AV NNP work_zbi2knhp65ho5n7vbsuthmd7gi 387 30 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 388 1 Anti- Anti- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 388 2 malaria malaria NN work_zbi2knhp65ho5n7vbsuthmd7gi 388 3 drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 388 4 blocks block VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 388 5 proteotoxic proteotoxic NNP work_zbi2knhp65ho5n7vbsuthmd7gi 388 6 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 388 7 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 388 8 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 388 9 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 388 10 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 388 11 cancer cancer JJ work_zbi2knhp65ho5n7vbsuthmd7gi 388 12 implications implication NNS work_zbi2knhp65ho5n7vbsuthmd7gi 388 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 389 1 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 389 2 Cycle Cycle NNP work_zbi2knhp65ho5n7vbsuthmd7gi 389 3 2009 2009 CD work_zbi2knhp65ho5n7vbsuthmd7gi 389 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 389 5 8:3960- 8:3960- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 389 6 70 70 CD work_zbi2knhp65ho5n7vbsuthmd7gi 389 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 389 8 PMID:19901558 PMID:19901558 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 389 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 389 10 http://dx.doi.org/10.4161/ http://dx.doi.org/10.4161/ NN work_zbi2knhp65ho5n7vbsuthmd7gi 389 11 cc.8.23.10179 cc.8.23.10179 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 389 12 19 19 CD work_zbi2knhp65ho5n7vbsuthmd7gi 389 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 390 1 Garber Garber NNP work_zbi2knhp65ho5n7vbsuthmd7gi 390 2 K. K. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 390 3 Inducing induce VBG work_zbi2knhp65ho5n7vbsuthmd7gi 390 4 indigestion indigestion NN work_zbi2knhp65ho5n7vbsuthmd7gi 390 5 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 390 6 companies company NNS work_zbi2knhp65ho5n7vbsuthmd7gi 390 7 embrace embrace VBP work_zbi2knhp65ho5n7vbsuthmd7gi 390 8 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 390 9 inhibitors inhibitor NNS work_zbi2knhp65ho5n7vbsuthmd7gi 390 10 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 391 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 391 2 Natl Natl NNP work_zbi2knhp65ho5n7vbsuthmd7gi 391 3 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 391 4 Inst Inst NNP work_zbi2knhp65ho5n7vbsuthmd7gi 391 5 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 391 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 391 7 103:708 103:708 CD work_zbi2knhp65ho5n7vbsuthmd7gi 391 8 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 391 9 10 10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 391 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 391 11 PMID:21515831 PMID:21515831 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 391 12 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 391 13 http://dx.doi http://dx.doi UH work_zbi2knhp65ho5n7vbsuthmd7gi 391 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 392 1 org/10.1093 org/10.1093 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 392 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 392 3 jnci jnci NNP work_zbi2knhp65ho5n7vbsuthmd7gi 392 4 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 392 5 djr168 djr168 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 392 6 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 392 7 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 393 1 Sharma Sharma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 2 N N NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 393 4 Thomas Thomas NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 5 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 393 7 Golden Golden NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 8 EB EB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 393 10 Hofman Hofman NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 11 FM FM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 393 13 Chen Chen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 14 TC TC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 393 16 Petasis Petasis NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 17 NA NA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 393 19 Schönthal Schönthal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 20 AH AH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 393 22 Louie Louie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 23 SG SG NNP work_zbi2knhp65ho5n7vbsuthmd7gi 393 24 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 394 1 Inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 394 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 394 3 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 394 4 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 394 5 induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 394 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 394 7 breast breast NN work_zbi2knhp65ho5n7vbsuthmd7gi 394 8 can- can- NN work_zbi2knhp65ho5n7vbsuthmd7gi 394 9 cer cer NN work_zbi2knhp65ho5n7vbsuthmd7gi 394 10 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 394 11 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 394 12 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 394 13 mef mef NN work_zbi2knhp65ho5n7vbsuthmd7gi 394 14 loquine loquine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 394 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 394 16 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 394 17 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 394 18 agent agent NN work_zbi2knhp65ho5n7vbsuthmd7gi 394 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 395 1 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 395 2 Lett Lett NNP work_zbi2knhp65ho5n7vbsuthmd7gi 395 3 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 395 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 395 5 326:143 326:143 CD work_zbi2knhp65ho5n7vbsuthmd7gi 395 6 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 395 7 54 54 CD work_zbi2knhp65ho5n7vbsuthmd7gi 395 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 395 9 PMID:22863539 pmid:22863539 NN work_zbi2knhp65ho5n7vbsuthmd7gi 395 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 395 11 http://dx.doi.org/10.1016/j.canlet.2012.07.029 http://dx.doi.org/10.1016/j.canlet.2012.07.029 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 395 12 21 21 CD work_zbi2knhp65ho5n7vbsuthmd7gi 395 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 396 1 Solomon Solomon NNP work_zbi2knhp65ho5n7vbsuthmd7gi 396 2 VR VR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 396 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 396 4 Lee Lee NNP work_zbi2knhp65ho5n7vbsuthmd7gi 396 5 H. H. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 396 6 Chloroquine Chloroquine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 396 7 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 396 8 its -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 396 9 analogs analog NNS work_zbi2knhp65ho5n7vbsuthmd7gi 396 10 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 396 11 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 396 12 new new JJ work_zbi2knhp65ho5n7vbsuthmd7gi 396 13 promise promise NN work_zbi2knhp65ho5n7vbsuthmd7gi 396 14 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 396 15 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 396 16 old old JJ work_zbi2knhp65ho5n7vbsuthmd7gi 396 17 drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 396 18 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 396 19 effective effective JJ work_zbi2knhp65ho5n7vbsuthmd7gi 396 20 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 396 21 safe safe JJ work_zbi2knhp65ho5n7vbsuthmd7gi 396 22 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 396 23 therapies therapy NNS work_zbi2knhp65ho5n7vbsuthmd7gi 396 24 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 397 1 Eur Eur NNP work_zbi2knhp65ho5n7vbsuthmd7gi 397 2 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 397 3 Pharmacol Pharmacol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 397 4 2009 2009 CD work_zbi2knhp65ho5n7vbsuthmd7gi 397 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 397 6 625:220- 625:220- CD work_zbi2knhp65ho5n7vbsuthmd7gi 397 7 33 33 CD work_zbi2knhp65ho5n7vbsuthmd7gi 397 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 397 9 PMID:19836374 PMID:19836374 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 397 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 397 11 http://dx.doi.org/10.1016/j http://dx.doi.org/10.1016/j NNP work_zbi2knhp65ho5n7vbsuthmd7gi 397 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 398 1 ejphar.2009.06.063 ejphar.2009.06.063 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 398 2 22 22 CD work_zbi2knhp65ho5n7vbsuthmd7gi 398 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 399 1 Sukhai Sukhai NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 2 MA MA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 399 4 Prabha Prabha NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 5 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 399 7 Hurren Hurren NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 8 R R NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 399 10 Rutledge Rutledge NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 11 AC AC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 399 13 Lee Lee NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 14 AY AY NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 399 16 Sriskanthadevan Sriskanthadevan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 17 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 399 19 Sun Sun NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 20 H H NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 399 22 Wang Wang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 23 X X NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 399 25 Skrtic Skrtic NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 26 M M NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 27 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 399 28 Seneviratne Seneviratne NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 29 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 30 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 399 31 et et NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 32 al al NNP work_zbi2knhp65ho5n7vbsuthmd7gi 399 33 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 400 1 Lysosomal Lysosomal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 400 2 disrup- disrup- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 400 3 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 400 4 preferentially preferentially RB work_zbi2knhp65ho5n7vbsuthmd7gi 400 5 targets target VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 400 6 acute acute JJ work_zbi2knhp65ho5n7vbsuthmd7gi 400 7 myeloid myeloid JJ work_zbi2knhp65ho5n7vbsuthmd7gi 400 8 leukemia leukemia NNP work_zbi2knhp65ho5n7vbsuthmd7gi 400 9 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 400 10 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 400 11 progenitors progenitor NNS work_zbi2knhp65ho5n7vbsuthmd7gi 400 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 401 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 401 2 Clin Clin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 401 3 Invest Invest NNP work_zbi2knhp65ho5n7vbsuthmd7gi 401 4 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 401 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 401 6 123:315- 123:315- CD work_zbi2knhp65ho5n7vbsuthmd7gi 401 7 28 28 CD work_zbi2knhp65ho5n7vbsuthmd7gi 401 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 401 9 PMID:23202731 pmid:23202731 NN work_zbi2knhp65ho5n7vbsuthmd7gi 401 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 401 11 http://dx.doi.org/10.1172/ http://dx.doi.org/10.1172/ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 401 12 JCI64180 JCI64180 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 401 13 23 23 CD work_zbi2knhp65ho5n7vbsuthmd7gi 401 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 402 1 Bristol Bristol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 402 2 ML ML NNP work_zbi2knhp65ho5n7vbsuthmd7gi 402 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 402 4 Emery Emery NNP work_zbi2knhp65ho5n7vbsuthmd7gi 402 5 SM SM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 402 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 402 7 Maycotte Maycotte NNP work_zbi2knhp65ho5n7vbsuthmd7gi 402 8 P P NNP work_zbi2knhp65ho5n7vbsuthmd7gi 402 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 402 10 Thorburn Thorburn NNP work_zbi2knhp65ho5n7vbsuthmd7gi 402 11 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 402 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 402 13 Chakradeo Chakradeo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 402 14 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 402 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 402 16 Gewirtz Gewirtz NNP work_zbi2knhp65ho5n7vbsuthmd7gi 402 17 DA DA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 402 18 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 403 1 Autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 403 2 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 403 3 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 403 4 chemosensitization chemosensitization NN work_zbi2knhp65ho5n7vbsuthmd7gi 403 5 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 403 6 radiosensitization radiosensitization NN work_zbi2knhp65ho5n7vbsuthmd7gi 403 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 403 8 can- can- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 403 9 cer cer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 403 10 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 403 11 do do VB work_zbi2knhp65ho5n7vbsuthmd7gi 403 12 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 403 13 preclinical preclinical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 403 14 data data NN work_zbi2knhp65ho5n7vbsuthmd7gi 403 15 support support NN work_zbi2knhp65ho5n7vbsuthmd7gi 403 16 this this DT work_zbi2knhp65ho5n7vbsuthmd7gi 403 17 therapeutic therapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 403 18 strategy strategy NN work_zbi2knhp65ho5n7vbsuthmd7gi 403 19 ? ? . work_zbi2knhp65ho5n7vbsuthmd7gi 404 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 404 2 Pharmacol Pharmacol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 404 3 Exp Exp NNP work_zbi2knhp65ho5n7vbsuthmd7gi 404 4 Ther Ther NNP work_zbi2knhp65ho5n7vbsuthmd7gi 404 5 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 404 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 404 7 344:544- 344:544- CD work_zbi2knhp65ho5n7vbsuthmd7gi 404 8 52 52 CD work_zbi2knhp65ho5n7vbsuthmd7gi 404 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 404 10 PMID:23291713 PMID:23291713 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 404 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 404 12 http://dx.doi.org/10.1124/ http://dx.doi.org/10.1124/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 404 13 jpet.112.199802 jpet.112.199802 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 404 14 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 404 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 405 1 Kimura Kimura NNP work_zbi2knhp65ho5n7vbsuthmd7gi 405 2 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 405 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 405 4 Takabatake Takabatake NNP work_zbi2knhp65ho5n7vbsuthmd7gi 405 5 Y Y NNP work_zbi2knhp65ho5n7vbsuthmd7gi 405 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 405 7 Takahashi Takahashi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 405 8 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 405 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 405 10 Isaka Isaka NNP work_zbi2knhp65ho5n7vbsuthmd7gi 405 11 Y. Y. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 405 12 Chloroquine Chloroquine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 405 13 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 405 14 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 405 15 therapy therapy NN work_zbi2knhp65ho5n7vbsuthmd7gi 405 16 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 405 17 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 405 18 double double JJ work_zbi2knhp65ho5n7vbsuthmd7gi 405 19 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 405 20 edged edged JJ work_zbi2knhp65ho5n7vbsuthmd7gi 405 21 sword sword NN work_zbi2knhp65ho5n7vbsuthmd7gi 405 22 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 405 23 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 405 24 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 406 1 Cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 406 2 Res Res NNP work_zbi2knhp65ho5n7vbsuthmd7gi 406 3 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 406 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 406 5 73:3 73:3 CD work_zbi2knhp65ho5n7vbsuthmd7gi 406 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 406 7 7 7 CD work_zbi2knhp65ho5n7vbsuthmd7gi 406 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 406 9 PMID:23288916 PMID:23288916 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 406 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 406 11 http://dx.doi.org/10.1158/0008- http://dx.doi.org/10.1158/0008- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 406 12 5472.CAN-12 5472.can-12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 406 13 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 406 14 2464 2464 CD work_zbi2knhp65ho5n7vbsuthmd7gi 406 15 25 25 CD work_zbi2knhp65ho5n7vbsuthmd7gi 406 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 407 1 Garbe Garbe NNP work_zbi2knhp65ho5n7vbsuthmd7gi 407 2 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 407 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 407 4 Eigentler Eigentler NNP work_zbi2knhp65ho5n7vbsuthmd7gi 407 5 TK TK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 407 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 407 7 Keilholz Keilholz NNP work_zbi2knhp65ho5n7vbsuthmd7gi 407 8 U U NNP work_zbi2knhp65ho5n7vbsuthmd7gi 407 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 407 10 Hauschild Hauschild NNP work_zbi2knhp65ho5n7vbsuthmd7gi 407 11 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 407 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 407 13 Kirkwood Kirkwood NNP work_zbi2knhp65ho5n7vbsuthmd7gi 407 14 JM JM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 407 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 408 1 Systematic systematic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 408 2 review review NN work_zbi2knhp65ho5n7vbsuthmd7gi 408 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 408 4 medical medical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 408 5 treat- treat- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 408 6 ment ment NN work_zbi2knhp65ho5n7vbsuthmd7gi 408 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 408 8 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 408 9 : : . work_zbi2knhp65ho5n7vbsuthmd7gi 408 10 current current JJ work_zbi2knhp65ho5n7vbsuthmd7gi 408 11 status status NN work_zbi2knhp65ho5n7vbsuthmd7gi 408 12 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 408 13 future future JJ work_zbi2knhp65ho5n7vbsuthmd7gi 408 14 pros- pros- NN work_zbi2knhp65ho5n7vbsuthmd7gi 408 15 pects pect NNS work_zbi2knhp65ho5n7vbsuthmd7gi 408 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 409 1 Oncologist Oncologist NNP work_zbi2knhp65ho5n7vbsuthmd7gi 409 2 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 409 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 409 4 16:5 16:5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 409 5 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 409 6 24 24 CD work_zbi2knhp65ho5n7vbsuthmd7gi 409 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 409 8 PMID:21212434 pmid:21212434 NN work_zbi2knhp65ho5n7vbsuthmd7gi 409 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 409 10 http://dx.doi.org/10.1634/theoncologist.2010-0190 http://dx.doi.org/10.1634/theoncologist.2010-0190 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 409 11 26 26 CD work_zbi2knhp65ho5n7vbsuthmd7gi 409 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 410 1 Ibrahim Ibrahim NNP work_zbi2knhp65ho5n7vbsuthmd7gi 410 2 N N NNP work_zbi2knhp65ho5n7vbsuthmd7gi 410 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 410 4 Haluska Haluska NNP work_zbi2knhp65ho5n7vbsuthmd7gi 410 5 FG FG NNP work_zbi2knhp65ho5n7vbsuthmd7gi 410 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 411 1 Molecular molecular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 411 2 pathogenesis pathogenesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 411 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 411 4 cutaneous cutaneous JJ work_zbi2knhp65ho5n7vbsuthmd7gi 411 5 melanocytic melanocytic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 411 6 neoplasms neoplasm NNS work_zbi2knhp65ho5n7vbsuthmd7gi 411 7 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 412 1 Annu Annu NNP work_zbi2knhp65ho5n7vbsuthmd7gi 412 2 Rev Rev NNP work_zbi2knhp65ho5n7vbsuthmd7gi 412 3 Pathol Pathol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 412 4 2009 2009 CD work_zbi2knhp65ho5n7vbsuthmd7gi 412 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 412 6 4:551 4:551 CD work_zbi2knhp65ho5n7vbsuthmd7gi 412 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 412 8 79 79 CD work_zbi2knhp65ho5n7vbsuthmd7gi 412 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 412 10 PMID:19400696 pmid:19400696 NN work_zbi2knhp65ho5n7vbsuthmd7gi 412 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 412 12 http://dx.doi http://dx.doi UH work_zbi2knhp65ho5n7vbsuthmd7gi 412 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 413 1 org/10.1146 org/10.1146 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 413 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 413 3 annurev.pathol.3.121806.151541 annurev.pathol.3.121806.151541 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 413 4 27 27 CD work_zbi2knhp65ho5n7vbsuthmd7gi 413 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 414 1 Aplin Aplin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 414 2 AE AE NNP work_zbi2knhp65ho5n7vbsuthmd7gi 414 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 414 4 Kaplan Kaplan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 414 5 FM FM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 414 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 414 7 Shao Shao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 414 8 Y. Y. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 414 9 Mechanisms Mechanisms NNP work_zbi2knhp65ho5n7vbsuthmd7gi 414 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 414 11 resistance resistance NN work_zbi2knhp65ho5n7vbsuthmd7gi 414 12 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 414 13 R R NNP work_zbi2knhp65ho5n7vbsuthmd7gi 414 14 AF AF NNP work_zbi2knhp65ho5n7vbsuthmd7gi 414 15 inhibitors inhibitor NNS work_zbi2knhp65ho5n7vbsuthmd7gi 414 16 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 414 17 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 414 18 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 415 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 415 2 Invest Invest NNP work_zbi2knhp65ho5n7vbsuthmd7gi 415 3 Dermatol Dermatol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 415 4 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 415 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 415 6 131:1817 131:1817 CD work_zbi2knhp65ho5n7vbsuthmd7gi 415 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 415 8 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 415 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 415 10 PMID:21593776 PMID:21593776 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 415 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 415 12 http://dx.doi.org/10.1038/jid.2011.147 http://dx.doi.org/10.1038/jid.2011.147 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 415 13 28 28 CD work_zbi2knhp65ho5n7vbsuthmd7gi 415 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 416 1 Armstrong Armstrong NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 2 JL JL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 416 4 Corazzari Corazzari NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 5 M M NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 416 7 Martin Martin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 8 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 416 10 Pagliarini Pagliarini NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 11 V V NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 416 13 Falasca Falasca NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 14 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 416 16 Hill Hill NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 17 DS DS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 416 19 Ellis Ellis NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 20 N N NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 416 22 Al Al NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 23 Sabah Sabah NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 24 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 25 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 416 26 Redfern Redfern NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 27 CP CP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 28 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 416 29 Fimia Fimia NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 30 GM GM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 31 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 416 32 et et NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 33 al al NNP work_zbi2knhp65ho5n7vbsuthmd7gi 416 34 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 417 1 Oncogenic oncogenic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 417 2 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 417 3 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 417 4 R R NNP work_zbi2knhp65ho5n7vbsuthmd7gi 417 5 AF AF NNP work_zbi2knhp65ho5n7vbsuthmd7gi 417 6 signaling signal VBG work_zbi2knhp65ho5n7vbsuthmd7gi 417 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 417 8 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 417 9 impairs impairs VB work_zbi2knhp65ho5n7vbsuthmd7gi 417 10 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 417 11 therapeutic therapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 417 12 advantage advantage NN work_zbi2knhp65ho5n7vbsuthmd7gi 417 13 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 417 14 auto- auto- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 417 15 phagy phagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 417 16 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 417 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 418 1 Clin Clin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 418 2 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 418 3 Res Res NNP work_zbi2knhp65ho5n7vbsuthmd7gi 418 4 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 418 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 418 6 17:2216 17:2216 CD work_zbi2knhp65ho5n7vbsuthmd7gi 418 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 418 8 26 26 CD work_zbi2knhp65ho5n7vbsuthmd7gi 418 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 418 10 PMID:21270111 PMID:21270111 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 418 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 418 12 http://dx.doi.org/10.1158/1078- http://dx.doi.org/10.1158/1078- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 418 13 0432.CCR-10 0432.ccr-10 CD work_zbi2knhp65ho5n7vbsuthmd7gi 418 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 418 15 3003 3003 CD work_zbi2knhp65ho5n7vbsuthmd7gi 418 16 29 29 CD work_zbi2knhp65ho5n7vbsuthmd7gi 418 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 419 1 Marino Marino NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 2 ML ML NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 419 4 Pellegrini Pellegrini NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 5 P P NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 419 7 Di Di NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 8 Lernia Lernia NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 9 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 419 11 Djavaheri- Djavaheri- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 12 Mergny Mergny NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 13 M M NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 419 15 Brnjic Brnjic NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 16 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 419 18 Zhang Zhang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 19 X X NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 419 21 Hägg Hägg NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 22 M M NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 419 24 Linder Linder NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 25 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 419 27 Fais Fais NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 28 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 29 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 419 30 Codogno Codogno NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 31 P P NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 32 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 419 33 et et NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 34 al al NNP work_zbi2knhp65ho5n7vbsuthmd7gi 419 35 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 420 1 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 420 2 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 420 3 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 420 4 protective protective JJ work_zbi2knhp65ho5n7vbsuthmd7gi 420 5 mecha- mecha- NN work_zbi2knhp65ho5n7vbsuthmd7gi 420 6 nism nism NN work_zbi2knhp65ho5n7vbsuthmd7gi 420 7 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 420 8 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 420 9 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 420 10 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 420 11 under under IN work_zbi2knhp65ho5n7vbsuthmd7gi 420 12 acidic acidic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 420 13 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 420 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 421 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 2 Biol Biol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 3 Chem Chem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 4 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 421 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 421 6 287:30664 287:30664 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 421 8 76 76 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 421 10 PMID:22761435 pmid:22761435 NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 421 12 http://dx.doi.org/10.1074/jbc.M112.339127 http://dx.doi.org/10.1074/jbc.m112.339127 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 421 13 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17712358&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=17712358&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 421 14 http://dx.doi.org/10.1038/nrm2245 http://dx.doi.org/10.1038/nrm2245 NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 15 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18305538&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18305538&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 16 http://dx.doi.org/10.1038/nature06639 http://dx.doi.org/10.1038/nature06639 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 17 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18804433&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18804433&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 18 http://dx.doi.org/10.1016/j.devcel.2008.08.012 http://dx.doi.org/10.1016/j.devcel.2008.08.012 -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 421 19 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22935804&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22935804&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 20 http://dx.doi.org/10.1038/nrd3802 http://dx.doi.org/10.1038/nrd3802 NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 21 http://dx.doi.org/10.1038/nrd3802 http://dx.doi.org/10.1038/nrd3802 NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 22 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23070014&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23070014&dopt=Abstract . work_zbi2knhp65ho5n7vbsuthmd7gi 421 23 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23070014&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23070014&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 421 24 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23589329&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23589329&dopt=Abstract NNS work_zbi2knhp65ho5n7vbsuthmd7gi 421 25 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23589329&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23589329&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 421 26 http://dx.doi.org/10.1128/MCB.01748-12 http://dx.doi.org/10.1128/mcb.01748-12 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 421 27 http://dx.doi.org/10.1128/MCB.01748-12 http://dx.doi.org/10.1128/mcb.01748-12 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 421 28 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21773629&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21773629&dopt=abstract RB work_zbi2knhp65ho5n7vbsuthmd7gi 421 29 http://dx.doi.org/10.1039/c1pp05131h http://dx.doi.org/10.1039/c1pp05131h ADD work_zbi2knhp65ho5n7vbsuthmd7gi 421 30 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23603447&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23603447&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 31 http://dx.doi.org/10.1016/j.jphotobiol.2013.03.007 http://dx.doi.org/10.1016/j.jphotobiol.2013.03.007 CC work_zbi2knhp65ho5n7vbsuthmd7gi 421 32 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21325294&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21325294&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 33 http://dx.doi.org/10.1158/1078-0432.CCR-10-2634 http://dx.doi.org/10.1158/1078-0432.CCR-10-2634 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 421 34 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21575862&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21575862&dopt=Abstract . work_zbi2knhp65ho5n7vbsuthmd7gi 421 35 http://dx.doi.org/10.1016/j.ccr.2011.03.012 http://dx.doi.org/10.1016/j.ccr.2011.03.012 NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 421 36 http://dx.doi.org/10.1016/j.ccr.2011.03.012 http://dx.doi.org/10.1016/j.ccr.2011.03.012 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 37 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21371883&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21371883&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 38 http://dx.doi.org/10.1016/j.ejca.2011.01.019 http://dx.doi.org/10.1016/j.ejca.2011.01.019 NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 39 http://dx.doi.org/10.1016/j.ejca.2011.01.019 http://dx.doi.org/10.1016/j.ejca.2011.01.019 IN work_zbi2knhp65ho5n7vbsuthmd7gi 421 40 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21325880&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21325880&dopt=abstract NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 41 http://dx.doi.org/10.4161/auto.7.5.15066 http://dx.doi.org/10.4161/auto.7.5.15066 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 42 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17235397&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17235397&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 43 http://dx.doi.org/10.1172/JCI28833 http://dx.doi.org/10.1172/jci28833 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 421 44 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19305139&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19305139&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 421 45 http://dx.doi.org/10.4161/auto.5.3.7827 http://dx.doi.org/10.4161/auto.5.3.7827 NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 46 http://dx.doi.org/10.4161/auto.5.3.7827 http://dx.doi.org/10.4161/auto.5.3.7827 CD work_zbi2knhp65ho5n7vbsuthmd7gi 421 47 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23383069&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23383069&dopt=Abstract NNS work_zbi2knhp65ho5n7vbsuthmd7gi 421 48 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23383069&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23383069&dopt=abstract NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 49 http://dx.doi.org/10.1371/journal.pone.0055096 http://dx.doi.org/10.1371/journal.pone.0055096 FW work_zbi2knhp65ho5n7vbsuthmd7gi 421 50 http://dx.doi.org/10.1371/journal.pone.0055096 http://dx.doi.org/10.1371/journal.pone.0055096 NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 51 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22246671&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22246671&dopt=Abstract NNS work_zbi2knhp65ho5n7vbsuthmd7gi 421 52 http://dx.doi.org/10.1158/0008-5472.CAN-11-3439 http://dx.doi.org/10.1158/0008-5472.CAN-11-3439 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 421 53 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19901558&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19901558&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 421 54 http://dx.doi.org/10.4161/cc.8.23.10179 http://dx.doi.org/10.4161/cc.8.23.10179 NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 55 http://dx.doi.org/10.4161/cc.8.23.10179 http://dx.doi.org/10.4161/cc.8.23.10179 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 56 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21515831&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21515831&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 57 http://dx.doi.org/10.1093/jnci/djr168 http://dx.doi.org/10.1093/jnci/djr168 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 58 http://dx.doi.org/10.1093/jnci/djr168 http://dx.doi.org/10.1093/jnci/djr168 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 59 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22863539&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22863539&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 60 http://dx.doi.org/10.1016/j.canlet.2012.07.029 http://dx.doi.org/10.1016/j.canlet.2012.07.029 VBD work_zbi2knhp65ho5n7vbsuthmd7gi 421 61 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19836374&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19836374&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 62 http://dx.doi.org/10.1016/j.ejphar.2009.06.063 http://dx.doi.org/10.1016/j.ejphar.2009.06.063 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 63 http://dx.doi.org/10.1016/j.ejphar.2009.06.063 http://dx.doi.org/10.1016/j.ejphar.2009.06.063 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 64 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23202731&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23202731&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 65 http://dx.doi.org/10.1172/JCI64180 http://dx.doi.org/10.1172/JCI64180 VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 421 66 http://dx.doi.org/10.1172/JCI64180 http://dx.doi.org/10.1172/jci64180 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 421 67 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23291713&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23291713&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 68 http://dx.doi.org/10.1124/jpet.112.199802 http://dx.doi.org/10.1124/jpet.112.199802 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 69 http://dx.doi.org/10.1124/jpet.112.199802 http://dx.doi.org/10.1124/jpet.112.199802 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 70 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23288916&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23288916&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 71 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23288916&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23288916&dopt=abstract PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 421 72 http://dx.doi.org/10.1158/0008-5472.CAN-12-2464 http://dx.doi.org/10.1158/0008-5472.can-12-2464 NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 73 http://dx.doi.org/10.1158/0008-5472.CAN-12-2464 http://dx.doi.org/10.1158/0008-5472.can-12-2464 NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 74 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21212434&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21212434&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 75 http://dx.doi.org/10.1634/theoncologist.2010-0190 http://dx.doi.org/10.1634/theoncologist.2010-0190 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 76 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19400696&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19400696&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 421 77 http://dx.doi.org/10.1146/annurev.pathol.3.121806.151541 http://dx.doi.org/10.1146/annurev.pathol.3.121806.151541 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 78 http://dx.doi.org/10.1146/annurev.pathol.3.121806.151541 http://dx.doi.org/10.1146/annurev.pathol.3.121806.151541 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 79 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21593776&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21593776&dopt=abstract WRB work_zbi2knhp65ho5n7vbsuthmd7gi 421 80 http://dx.doi.org/10.1038/jid.2011.147 http://dx.doi.org/10.1038/jid.2011.147 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 81 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21270111&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21270111&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 82 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21270111&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21270111&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 83 http://dx.doi.org/10.1158/1078-0432.CCR-10-3003 http://dx.doi.org/10.1158/1078-0432.CCR-10-3003 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 421 84 http://dx.doi.org/10.1158/1078-0432.CCR-10-3003 http://dx.doi.org/10.1158/1078-0432.ccr-10-3003 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 421 85 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22761435&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22761435&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 86 http://dx.doi.org/10.1074/jbc.M112.339127 http://dx.doi.org/10.1074/jbc.M112.339127 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 87 © © NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 88 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 421 89 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 421 90 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 91 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 421 92 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 93 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 94 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 95 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 421 96 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 421 97 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 98 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 421 99 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 100 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 101 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 102 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 421 103 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 104 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 421 105 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 421 106 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 421 107 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 421 108 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 421 109 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 110 www.landesbioscience.com www.landesbioscience.com NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 111 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 421 112 2101 2101 CD work_zbi2knhp65ho5n7vbsuthmd7gi 421 113 30 30 CD work_zbi2knhp65ho5n7vbsuthmd7gi 421 114 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 422 1 Ma Ma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 2 XH xh NN work_zbi2knhp65ho5n7vbsuthmd7gi 422 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 422 4 Piao Piao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 5 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 422 7 Wang Wang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 8 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 422 10 McAfee McAfee NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 11 QW QW NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 422 13 Nathanson Nathanson NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 14 KL KL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 422 16 Lum Lum NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 17 JJ JJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 422 19 Li Li NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 20 LZ LZ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 422 22 Amaravadi Amaravadi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 23 RK RK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 422 24 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 423 1 Measurements measurement NNS work_zbi2knhp65ho5n7vbsuthmd7gi 423 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 423 3 tumor tumor NN work_zbi2knhp65ho5n7vbsuthmd7gi 423 4 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 423 5 autophagy autophagy NNS work_zbi2knhp65ho5n7vbsuthmd7gi 423 6 predict predict VBP work_zbi2knhp65ho5n7vbsuthmd7gi 423 7 invasiveness invasiveness NNP work_zbi2knhp65ho5n7vbsuthmd7gi 423 8 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 423 9 resistance resistance NN work_zbi2knhp65ho5n7vbsuthmd7gi 423 10 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 423 11 chemotherapy chemotherapy NN work_zbi2knhp65ho5n7vbsuthmd7gi 423 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 423 13 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 423 14 survival survival NN work_zbi2knhp65ho5n7vbsuthmd7gi 423 15 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 423 16 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 423 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 424 1 Clin Clin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 424 2 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 424 3 Res Res NNP work_zbi2knhp65ho5n7vbsuthmd7gi 424 4 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 424 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 424 6 17:3478 17:3478 CD work_zbi2knhp65ho5n7vbsuthmd7gi 424 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 424 8 89 89 CD work_zbi2knhp65ho5n7vbsuthmd7gi 424 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 424 10 PMID:21325076 pmid:21325076 NN work_zbi2knhp65ho5n7vbsuthmd7gi 424 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 424 12 http://dx.doi.org/10.1158/1078-0432.CCR-10-2372 http://dx.doi.org/10.1158/1078-0432.CCR-10-2372 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 424 13 31 31 CD work_zbi2knhp65ho5n7vbsuthmd7gi 424 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 425 1 Flemming flemme VBG work_zbi2knhp65ho5n7vbsuthmd7gi 425 2 A. a. NN work_zbi2knhp65ho5n7vbsuthmd7gi 426 1 Cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 426 2 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 426 3 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 426 4 presents present VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 426 5 Achilles Achilles NNP work_zbi2knhp65ho5n7vbsuthmd7gi 426 6 heel heel NN work_zbi2knhp65ho5n7vbsuthmd7gi 426 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 426 8 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 426 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 427 1 Nat Nat NNP work_zbi2knhp65ho5n7vbsuthmd7gi 427 2 Rev Rev NNP work_zbi2knhp65ho5n7vbsuthmd7gi 427 3 Drug Drug NNP work_zbi2knhp65ho5n7vbsuthmd7gi 427 4 Discov Discov NNP work_zbi2knhp65ho5n7vbsuthmd7gi 427 5 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 427 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 427 7 10:491 10:491 CD work_zbi2knhp65ho5n7vbsuthmd7gi 427 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 427 9 PMID:21720400 PMID:21720400 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 427 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 427 11 http://dx.doi http://dx.doi NN work_zbi2knhp65ho5n7vbsuthmd7gi 427 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 428 1 org/10.1038 org/10.1038 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 428 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 428 3 nrd3482 nrd3482 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 428 4 32 32 CD work_zbi2knhp65ho5n7vbsuthmd7gi 428 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 429 1 Del Del NNP work_zbi2knhp65ho5n7vbsuthmd7gi 429 2 Bello Bello NNP work_zbi2knhp65ho5n7vbsuthmd7gi 429 3 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 429 4 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 429 5 Toscano Toscano NNP work_zbi2knhp65ho5n7vbsuthmd7gi 429 6 M M NNP work_zbi2knhp65ho5n7vbsuthmd7gi 429 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 429 8 Moretti Moretti NNP work_zbi2knhp65ho5n7vbsuthmd7gi 429 9 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 429 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 429 11 Maellaro Maellaro NNP work_zbi2knhp65ho5n7vbsuthmd7gi 429 12 E. E. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 429 13 Cisplatin Cisplatin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 429 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 429 15 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 429 16 apoptosis apoptosis NN work_zbi2knhp65ho5n7vbsuthmd7gi 429 17 inhibits inhibit NNS work_zbi2knhp65ho5n7vbsuthmd7gi 429 18 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 429 19 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 429 20 which which WDT work_zbi2knhp65ho5n7vbsuthmd7gi 429 21 acts act VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 429 22 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 429 23 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 429 24 pro pro JJ work_zbi2knhp65ho5n7vbsuthmd7gi 429 25 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 429 26 survival survival JJ work_zbi2knhp65ho5n7vbsuthmd7gi 429 27 mechanism mechanism NN work_zbi2knhp65ho5n7vbsuthmd7gi 429 28 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 429 29 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 429 30 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 429 31 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 429 32 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 430 1 PLoS plos ADD work_zbi2knhp65ho5n7vbsuthmd7gi 430 2 One one CD work_zbi2knhp65ho5n7vbsuthmd7gi 430 3 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 430 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 430 5 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 430 6 : : SYM work_zbi2knhp65ho5n7vbsuthmd7gi 430 7 e57236 e57236 NN work_zbi2knhp65ho5n7vbsuthmd7gi 430 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 430 9 PMID:23437349 pmid:23437349 NN work_zbi2knhp65ho5n7vbsuthmd7gi 430 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 430 11 http://dx.doi.org/10.1371/jour- http://dx.doi.org/10.1371/jour- NFP work_zbi2knhp65ho5n7vbsuthmd7gi 430 12 nal.pone.0057236 nal.pone.0057236 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 430 13 33 33 CD work_zbi2knhp65ho5n7vbsuthmd7gi 430 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 431 1 Cabello Cabello NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 2 CM CM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 431 4 Lamore Lamore NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 5 SD SD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 431 7 Bair Bair NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 8 WB WB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 9 3rd 3rd NN work_zbi2knhp65ho5n7vbsuthmd7gi 431 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 431 11 Qiao Qiao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 12 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 431 14 Azimian Azimian NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 15 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 431 17 Lesson Lesson NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 18 JL JL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 19 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 431 20 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 21 GT GT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 431 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 432 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 432 2 redox redox JJ work_zbi2knhp65ho5n7vbsuthmd7gi 432 3 anti- anti- NN work_zbi2knhp65ho5n7vbsuthmd7gi 432 4 malarial malarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 432 5 dihydroartemisinin dihydroartemisinin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 432 6 targets targets NNP work_zbi2knhp65ho5n7vbsuthmd7gi 432 7 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 432 8 meta- meta- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 432 9 static static JJ work_zbi2knhp65ho5n7vbsuthmd7gi 432 10 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 432 11 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 432 12 but but CC work_zbi2knhp65ho5n7vbsuthmd7gi 432 13 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 432 14 primary primary JJ work_zbi2knhp65ho5n7vbsuthmd7gi 432 15 melanocytes melanocyte NNS work_zbi2knhp65ho5n7vbsuthmd7gi 432 16 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 432 17 induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 432 18 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 432 19 NOX NOX NNP work_zbi2knhp65ho5n7vbsuthmd7gi 432 20 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 432 21 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 432 22 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 432 23 apoptosis apoptosis NN work_zbi2knhp65ho5n7vbsuthmd7gi 432 24 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 433 1 Invest invest VB work_zbi2knhp65ho5n7vbsuthmd7gi 433 2 New new JJ work_zbi2knhp65ho5n7vbsuthmd7gi 433 3 Drugs drug NNS work_zbi2knhp65ho5n7vbsuthmd7gi 433 4 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 433 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 433 6 30:1289 30:1289 CD work_zbi2knhp65ho5n7vbsuthmd7gi 433 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 433 8 301 301 CD work_zbi2knhp65ho5n7vbsuthmd7gi 433 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 433 10 PMID:21547369 PMID:21547369 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 433 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 433 12 http://dx.doi.org/10.1007/s10637-011-9676-7 http://dx.doi.org/10.1007/s10637-011-9676-7 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 433 13 34 34 CD work_zbi2knhp65ho5n7vbsuthmd7gi 433 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 434 1 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 434 2 GT GT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 434 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 435 1 Redox redox NN work_zbi2knhp65ho5n7vbsuthmd7gi 435 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 435 3 directed direct VBN work_zbi2knhp65ho5n7vbsuthmd7gi 435 4 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 435 5 therapeutics therapeutic NNS work_zbi2knhp65ho5n7vbsuthmd7gi 435 6 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 435 7 molecular molecular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 435 8 mechanisms mechanism NNS work_zbi2knhp65ho5n7vbsuthmd7gi 435 9 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 435 10 opportunities opportunity NNS work_zbi2knhp65ho5n7vbsuthmd7gi 435 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 436 1 Antioxid Antioxid NNP work_zbi2knhp65ho5n7vbsuthmd7gi 436 2 Redox Redox NNP work_zbi2knhp65ho5n7vbsuthmd7gi 436 3 Signal Signal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 436 4 2009 2009 CD work_zbi2knhp65ho5n7vbsuthmd7gi 436 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 436 6 11:3013 11:3013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 436 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 436 8 69 69 CD work_zbi2knhp65ho5n7vbsuthmd7gi 436 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 436 10 PMID:19496700 pmid:19496700 NN work_zbi2knhp65ho5n7vbsuthmd7gi 436 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 436 12 http://dx.doi.org/10.1089/ars.2009.2541 http://dx.doi.org/10.1089/ars.2009.2541 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 436 13 35 35 CD work_zbi2knhp65ho5n7vbsuthmd7gi 436 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 437 1 Eastman Eastman NNP work_zbi2knhp65ho5n7vbsuthmd7gi 437 2 RT RT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 437 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 437 4 Fidock Fidock NNP work_zbi2knhp65ho5n7vbsuthmd7gi 437 5 DA DA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 437 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 438 1 Artemisinin Artemisinin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 438 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 438 3 based base VBN work_zbi2knhp65ho5n7vbsuthmd7gi 438 4 com- com- NN work_zbi2knhp65ho5n7vbsuthmd7gi 438 5 bination bination NN work_zbi2knhp65ho5n7vbsuthmd7gi 438 6 therapies therapy NNS work_zbi2knhp65ho5n7vbsuthmd7gi 438 7 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 438 8 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 438 9 vital vital JJ work_zbi2knhp65ho5n7vbsuthmd7gi 438 10 tool tool NN work_zbi2knhp65ho5n7vbsuthmd7gi 438 11 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 438 12 efforts effort NNS work_zbi2knhp65ho5n7vbsuthmd7gi 438 13 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 438 14 elimi- elimi- VB work_zbi2knhp65ho5n7vbsuthmd7gi 438 15 nate nate JJ work_zbi2knhp65ho5n7vbsuthmd7gi 438 16 malaria malaria NN work_zbi2knhp65ho5n7vbsuthmd7gi 438 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 439 1 Nat Nat NNP work_zbi2knhp65ho5n7vbsuthmd7gi 439 2 Rev Rev NNP work_zbi2knhp65ho5n7vbsuthmd7gi 439 3 Microbiol Microbiol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 439 4 2009 2009 CD work_zbi2knhp65ho5n7vbsuthmd7gi 439 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 439 6 7:864 7:864 CD work_zbi2knhp65ho5n7vbsuthmd7gi 439 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 439 8 74 74 CD work_zbi2knhp65ho5n7vbsuthmd7gi 439 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 439 10 PMID:19881520 PMID:19881520 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 439 11 36 36 CD work_zbi2knhp65ho5n7vbsuthmd7gi 439 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 440 1 Anvikar Anvikar NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 2 AR AR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 440 4 Sharma Sharma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 5 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 440 7 Shahi Shahi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 8 BH BH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 440 10 Tyagi Tyagi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 11 PK PK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 440 13 Bose Bose NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 14 TK TK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 440 16 Sharma Sharma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 17 SK SK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 440 19 Srivastava Srivastava NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 20 P P NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 440 22 Srivastava Srivastava NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 23 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 440 25 Kiechel Kiechel NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 26 JR JR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 27 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 440 28 Dash Dash NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 29 AP AP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 30 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 440 31 et et NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 32 al al NNP work_zbi2knhp65ho5n7vbsuthmd7gi 440 33 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 441 1 Artesunate Artesunate NNP work_zbi2knhp65ho5n7vbsuthmd7gi 441 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 441 3 amodiaquine amodiaquine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 441 4 fixed fix VBN work_zbi2knhp65ho5n7vbsuthmd7gi 441 5 dose dose VBD work_zbi2knhp65ho5n7vbsuthmd7gi 441 6 combination combination NN work_zbi2knhp65ho5n7vbsuthmd7gi 441 7 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 441 8 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 441 9 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 441 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 441 11 Plasmodium Plasmodium NNP work_zbi2knhp65ho5n7vbsuthmd7gi 441 12 falciparum falciparum NN work_zbi2knhp65ho5n7vbsuthmd7gi 441 13 malaria malaria NN work_zbi2knhp65ho5n7vbsuthmd7gi 441 14 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 441 15 India India NNP work_zbi2knhp65ho5n7vbsuthmd7gi 441 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 442 1 Malar Malar NNP work_zbi2knhp65ho5n7vbsuthmd7gi 442 2 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 442 3 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 442 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 442 5 11:97 11:97 CD work_zbi2knhp65ho5n7vbsuthmd7gi 442 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 442 7 PMID:22458860 pmid:22458860 NN work_zbi2knhp65ho5n7vbsuthmd7gi 442 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 442 9 http://dx.doi http://dx.doi UH work_zbi2knhp65ho5n7vbsuthmd7gi 442 10 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 443 1 org/10.1186/1475 org/10.1186/1475 NN work_zbi2knhp65ho5n7vbsuthmd7gi 443 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 443 3 2875 2875 CD work_zbi2knhp65ho5n7vbsuthmd7gi 443 4 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 443 5 11 11 CD work_zbi2knhp65ho5n7vbsuthmd7gi 443 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 443 7 97 97 CD work_zbi2knhp65ho5n7vbsuthmd7gi 443 8 37 37 CD work_zbi2knhp65ho5n7vbsuthmd7gi 443 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 444 1 Lamore Lamore NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 2 SD SD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 444 4 Azimian Azimian NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 5 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 444 7 Horn Horn NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 8 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 444 10 Anglin Anglin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 11 BL BL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 444 13 Uchida Uchida NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 14 K K NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 444 16 Cabello Cabello NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 17 CM CM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 444 19 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 20 GT GT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 444 21 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 445 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 445 2 malondialdehyde- malondialdehyde- NN work_zbi2knhp65ho5n7vbsuthmd7gi 445 3 derived derive VBN work_zbi2knhp65ho5n7vbsuthmd7gi 445 4 f f NNP work_zbi2knhp65ho5n7vbsuthmd7gi 445 5 luorophore luorophore JJ work_zbi2knhp65ho5n7vbsuthmd7gi 445 6 DHP DHP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 445 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 445 8 lysine lysine NN work_zbi2knhp65ho5n7vbsuthmd7gi 445 9 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 445 10 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 445 11 potent potent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 445 12 sensitizer sensitizer NN work_zbi2knhp65ho5n7vbsuthmd7gi 445 13 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 445 14 UVA UVA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 445 15 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 445 16 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 445 17 photooxidative photooxidative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 445 18 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 445 19 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 445 20 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 445 21 skin skin NN work_zbi2knhp65ho5n7vbsuthmd7gi 445 22 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 445 23 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 446 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 446 2 Photochem Photochem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 446 3 Photobiol Photobiol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 446 4 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 446 5 2010 2010 CD work_zbi2knhp65ho5n7vbsuthmd7gi 446 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 446 7 101:251- 101:251- CD work_zbi2knhp65ho5n7vbsuthmd7gi 446 8 64 64 CD work_zbi2knhp65ho5n7vbsuthmd7gi 446 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 446 10 PMID:20724175 pmid:20724175 CD work_zbi2knhp65ho5n7vbsuthmd7gi 446 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 446 12 http://dx.doi.org/10.1016/j http://dx.doi.org/10.1016/j NNP work_zbi2knhp65ho5n7vbsuthmd7gi 446 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 447 1 jphotobiol.2010.07.010 jphotobiol.2010.07.010 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 447 2 38 38 CD work_zbi2knhp65ho5n7vbsuthmd7gi 447 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 448 1 Lamore Lamore NNP work_zbi2knhp65ho5n7vbsuthmd7gi 448 2 SD SD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 448 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 448 4 Qiao Qiao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 448 5 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 448 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 448 7 Horn Horn NNP work_zbi2knhp65ho5n7vbsuthmd7gi 448 8 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 448 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 448 10 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 448 11 GT GT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 448 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 449 1 Proteomic proteomic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 449 2 identification identification NN work_zbi2knhp65ho5n7vbsuthmd7gi 449 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 449 4 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 449 5 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 449 6 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 449 7 nucleophosmin nucleophosmin NN work_zbi2knhp65ho5n7vbsuthmd7gi 449 8 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 449 9 novel novel JJ work_zbi2knhp65ho5n7vbsuthmd7gi 449 10 UVA UVA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 449 11 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 449 12 targets target NNS work_zbi2knhp65ho5n7vbsuthmd7gi 449 13 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 449 14 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 449 15 skin skin NN work_zbi2knhp65ho5n7vbsuthmd7gi 449 16 fibroblasts fibroblast NNS work_zbi2knhp65ho5n7vbsuthmd7gi 449 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 450 1 Photochem Photochem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 450 2 Photobiol Photobiol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 450 3 2010 2010 CD work_zbi2knhp65ho5n7vbsuthmd7gi 450 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 450 5 86:1307 86:1307 CD work_zbi2knhp65ho5n7vbsuthmd7gi 450 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 450 7 17 17 CD work_zbi2knhp65ho5n7vbsuthmd7gi 450 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 450 9 PMID:20946361 pmid:20946361 NN work_zbi2knhp65ho5n7vbsuthmd7gi 450 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 450 11 http://dx.doi http://dx.doi UH work_zbi2knhp65ho5n7vbsuthmd7gi 450 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 451 1 org/10.1111 org/10.1111 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 451 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 451 3 j.1751 j.1751 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 451 4 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 451 5 1097.2010.00818.x 1097.2010.00818.x CD work_zbi2knhp65ho5n7vbsuthmd7gi 451 6 39 39 CD work_zbi2knhp65ho5n7vbsuthmd7gi 451 7 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 452 1 Eskelinen Eskelinen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 452 2 E E NNP work_zbi2knhp65ho5n7vbsuthmd7gi 452 3 - - NNP work_zbi2knhp65ho5n7vbsuthmd7gi 452 4 L. l. NN work_zbi2knhp65ho5n7vbsuthmd7gi 453 1 Roles role NNS work_zbi2knhp65ho5n7vbsuthmd7gi 453 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 453 3 LAMP-1 lamp-1 NN work_zbi2knhp65ho5n7vbsuthmd7gi 453 4 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 453 5 LAMP-2 LAMP-2 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 453 6 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 453 7 lysosome lysosome JJ work_zbi2knhp65ho5n7vbsuthmd7gi 453 8 biogenesis biogenesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 453 9 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 453 10 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 453 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 454 1 Mol Mol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 454 2 Aspects Aspects NNP work_zbi2knhp65ho5n7vbsuthmd7gi 454 3 Med Med NNP work_zbi2knhp65ho5n7vbsuthmd7gi 454 4 2006 2006 CD work_zbi2knhp65ho5n7vbsuthmd7gi 454 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 454 6 27:495 27:495 CD work_zbi2knhp65ho5n7vbsuthmd7gi 454 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 454 8 502 502 CD work_zbi2knhp65ho5n7vbsuthmd7gi 454 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 454 10 PMID:16973206 pmid:16973206 NN work_zbi2knhp65ho5n7vbsuthmd7gi 454 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 454 12 http://dx.doi http://dx.doi UH work_zbi2knhp65ho5n7vbsuthmd7gi 454 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 455 1 org/10.1016 org/10.1016 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 455 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 455 3 j.mam.2006.08.005 j.mam.2006.08.005 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 455 4 40 40 CD work_zbi2knhp65ho5n7vbsuthmd7gi 455 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 456 1 Mizushima Mizushima NNP work_zbi2knhp65ho5n7vbsuthmd7gi 456 2 N N NNP work_zbi2knhp65ho5n7vbsuthmd7gi 456 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 456 4 Yoshimori Yoshimori NNP work_zbi2knhp65ho5n7vbsuthmd7gi 456 5 T. T. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 456 6 How how WRB work_zbi2knhp65ho5n7vbsuthmd7gi 456 7 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 456 8 interpret interpret VB work_zbi2knhp65ho5n7vbsuthmd7gi 456 9 LC3 lc3 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 456 10 immunoblotting immunoblotte VBG work_zbi2knhp65ho5n7vbsuthmd7gi 456 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 457 1 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 457 2 2007 2007 CD work_zbi2knhp65ho5n7vbsuthmd7gi 457 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 457 4 3:542 3:542 CD work_zbi2knhp65ho5n7vbsuthmd7gi 457 5 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 457 6 5 5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 457 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 457 8 PMID:17611390 PMID:17611390 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 457 9 41 41 CD work_zbi2knhp65ho5n7vbsuthmd7gi 457 10 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 458 1 Ichimura Ichimura NNP work_zbi2knhp65ho5n7vbsuthmd7gi 458 2 Y Y NNP work_zbi2knhp65ho5n7vbsuthmd7gi 458 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 458 4 Kominami Kominami NNP work_zbi2knhp65ho5n7vbsuthmd7gi 458 5 E E NNP work_zbi2knhp65ho5n7vbsuthmd7gi 458 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 458 7 Tanaka Tanaka NNP work_zbi2knhp65ho5n7vbsuthmd7gi 458 8 K K NNP work_zbi2knhp65ho5n7vbsuthmd7gi 458 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 458 10 Komatsu Komatsu NNP work_zbi2knhp65ho5n7vbsuthmd7gi 458 11 M. M. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 458 12 Selective Selective NNP work_zbi2knhp65ho5n7vbsuthmd7gi 458 13 turnover turnover NN work_zbi2knhp65ho5n7vbsuthmd7gi 458 14 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 458 15 p62 p62 NN work_zbi2knhp65ho5n7vbsuthmd7gi 458 16 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 458 17 A170 A170 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 458 18 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 458 19 SQSTM1 SQSTM1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 458 20 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 458 21 auto- auto- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 458 22 phagy phagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 458 23 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 459 1 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 459 2 2008 2008 CD work_zbi2knhp65ho5n7vbsuthmd7gi 459 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 459 4 4:1063 4:1063 CD work_zbi2knhp65ho5n7vbsuthmd7gi 459 5 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 459 6 6 6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 459 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 459 8 PMID:18776737 PMID:18776737 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 459 9 42 42 CD work_zbi2knhp65ho5n7vbsuthmd7gi 459 10 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 460 1 Johansen Johansen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 460 2 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 460 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 460 4 Lamark Lamark NNP work_zbi2knhp65ho5n7vbsuthmd7gi 460 5 T. T. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 460 6 Selective Selective NNP work_zbi2knhp65ho5n7vbsuthmd7gi 460 7 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 460 8 medi- medi- NN work_zbi2knhp65ho5n7vbsuthmd7gi 460 9 ated ate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 460 10 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 460 11 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 460 12 adapter adapter NN work_zbi2knhp65ho5n7vbsuthmd7gi 460 13 proteins protein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 460 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 461 1 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 461 2 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 461 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 461 4 7:279 7:279 CD work_zbi2knhp65ho5n7vbsuthmd7gi 461 5 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 461 6 96 96 CD work_zbi2knhp65ho5n7vbsuthmd7gi 461 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 461 8 PMID:21189453 pmid:21189453 NN work_zbi2knhp65ho5n7vbsuthmd7gi 461 9 ; ; , work_zbi2knhp65ho5n7vbsuthmd7gi 461 10 http://dx.doi http://dx.doi UH work_zbi2knhp65ho5n7vbsuthmd7gi 461 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 462 1 org/10.4161 org/10.4161 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 462 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 462 3 auto.7.3.14487 auto.7.3.14487 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 462 4 43 43 CD work_zbi2knhp65ho5n7vbsuthmd7gi 462 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 463 1 Pankiv Pankiv NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 2 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 463 4 Clausen Clausen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 5 TH TH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 463 7 Lamark Lamark NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 8 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 463 10 Brech Brech NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 11 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 463 13 Bruun Bruun NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 14 JA JA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 463 16 Outzen Outzen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 17 H H NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 463 19 Øvervatn Øvervatn NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 20 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 463 22 Bjørkøy Bjørkøy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 23 G G NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 463 25 Johansen Johansen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 26 T. T. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 27 p62 p62 NN work_zbi2knhp65ho5n7vbsuthmd7gi 463 28 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 463 29 SQSTM1 SQSTM1 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 463 30 binds bind NNS work_zbi2knhp65ho5n7vbsuthmd7gi 463 31 directly directly RB work_zbi2knhp65ho5n7vbsuthmd7gi 463 32 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 463 33 Atg8 atg8 NN work_zbi2knhp65ho5n7vbsuthmd7gi 463 34 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 463 35 LC3 LC3 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 36 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 463 37 facili- facili- VB work_zbi2knhp65ho5n7vbsuthmd7gi 463 38 tate tate NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 39 degradation degradation NN work_zbi2knhp65ho5n7vbsuthmd7gi 463 40 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 463 41 ubiquitinated ubiquitinated JJ work_zbi2knhp65ho5n7vbsuthmd7gi 463 42 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 463 43 aggregates aggregate NNS work_zbi2knhp65ho5n7vbsuthmd7gi 463 44 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 463 45 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 463 46 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 464 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 464 2 Biol Biol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 464 3 Chem Chem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 464 4 2007 2007 CD work_zbi2knhp65ho5n7vbsuthmd7gi 464 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 464 6 282:24131 282:24131 LS work_zbi2knhp65ho5n7vbsuthmd7gi 464 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 464 8 45 45 CD work_zbi2knhp65ho5n7vbsuthmd7gi 464 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 464 10 PMID:17580304 PMID:17580304 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 464 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 464 12 http://dx.doi.org/10.1074/jbc http://dx.doi.org/10.1074/jbc ADD work_zbi2knhp65ho5n7vbsuthmd7gi 464 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 465 1 M702824200 M702824200 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 465 2 44 44 CD work_zbi2knhp65ho5n7vbsuthmd7gi 465 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 466 1 Kabuta Kabuta NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 2 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 466 4 Furuta Furuta NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 5 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 466 7 Aoki Aoki NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 8 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 466 10 Furuta Furuta NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 11 K K NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 466 13 Wada Wada NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 14 K. K. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 15 Aberrant Aberrant NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 16 interaction interaction NN work_zbi2knhp65ho5n7vbsuthmd7gi 466 17 between between IN work_zbi2knhp65ho5n7vbsuthmd7gi 466 18 Parkinson Parkinson NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 19 disease- disease- NN work_zbi2knhp65ho5n7vbsuthmd7gi 466 20 associated associate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 466 21 mutant mutant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 466 22 UCH UCH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 23 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 466 24 L1 L1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 466 25 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 466 26 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 466 27 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 466 28 recep- recep- VBD work_zbi2knhp65ho5n7vbsuthmd7gi 466 29 tor tor NN work_zbi2knhp65ho5n7vbsuthmd7gi 466 30 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 466 31 chaperone chaperone NN work_zbi2knhp65ho5n7vbsuthmd7gi 466 32 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 466 33 mediated mediate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 466 34 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 466 35 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 467 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 467 2 Biol Biol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 467 3 Chem Chem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 467 4 2008 2008 CD work_zbi2knhp65ho5n7vbsuthmd7gi 467 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 467 6 283:23731 283:23731 CD work_zbi2knhp65ho5n7vbsuthmd7gi 467 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 467 8 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 467 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 467 10 PMID:18550537 PMID:18550537 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 467 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 467 12 http://dx.doi http://dx.doi UH work_zbi2knhp65ho5n7vbsuthmd7gi 467 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 468 1 org/10.1074 org/10.1074 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 468 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 468 3 jbc jbc NN work_zbi2knhp65ho5n7vbsuthmd7gi 468 4 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 468 5 M801918200 M801918200 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 468 6 45 45 CD work_zbi2knhp65ho5n7vbsuthmd7gi 468 7 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 469 1 Sevlever sevlever NN work_zbi2knhp65ho5n7vbsuthmd7gi 469 2 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 469 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 469 4 Jiang Jiang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 469 5 P P NNP work_zbi2knhp65ho5n7vbsuthmd7gi 469 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 469 7 Yen yen NN work_zbi2knhp65ho5n7vbsuthmd7gi 469 8 SH SH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 469 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 470 1 Cathepsin Cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 470 2 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 470 3 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 470 4 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 470 5 main main JJ work_zbi2knhp65ho5n7vbsuthmd7gi 470 6 lysosomal lysosomal NN work_zbi2knhp65ho5n7vbsuthmd7gi 470 7 enzyme enzyme NNS work_zbi2knhp65ho5n7vbsuthmd7gi 470 8 involved involve VBN work_zbi2knhp65ho5n7vbsuthmd7gi 470 9 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 470 10 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 470 11 degradation degradation NN work_zbi2knhp65ho5n7vbsuthmd7gi 470 12 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 470 13 alpha alpha NN work_zbi2knhp65ho5n7vbsuthmd7gi 470 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 470 15 synuclein synuclein NNS work_zbi2knhp65ho5n7vbsuthmd7gi 470 16 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 470 17 generation generation NN work_zbi2knhp65ho5n7vbsuthmd7gi 470 18 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 470 19 its -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 470 20 carboxy carboxy NN work_zbi2knhp65ho5n7vbsuthmd7gi 470 21 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 470 22 termi- termi- NN work_zbi2knhp65ho5n7vbsuthmd7gi 470 23 nally nally RB work_zbi2knhp65ho5n7vbsuthmd7gi 470 24 truncated truncate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 470 25 species specie NNS work_zbi2knhp65ho5n7vbsuthmd7gi 470 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 471 1 Biochemistry Biochemistry NNP work_zbi2knhp65ho5n7vbsuthmd7gi 471 2 2008 2008 CD work_zbi2knhp65ho5n7vbsuthmd7gi 471 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 471 4 47:9678- 47:9678- CD work_zbi2knhp65ho5n7vbsuthmd7gi 471 5 87 87 CD work_zbi2knhp65ho5n7vbsuthmd7gi 471 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 471 7 PMID:18702517 PMID:18702517 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 471 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 471 9 http://dx.doi.org/10.1021/ http://dx.doi.org/10.1021/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 471 10 bi800699v bi800699v $ work_zbi2knhp65ho5n7vbsuthmd7gi 471 11 46 46 CD work_zbi2knhp65ho5n7vbsuthmd7gi 471 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 472 1 Wang Wang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 472 2 J. J. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 472 3 Beclin Beclin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 472 4 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 472 5 bridges bridge NNS work_zbi2knhp65ho5n7vbsuthmd7gi 472 6 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 472 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 472 8 apoptosis apoptosis NN work_zbi2knhp65ho5n7vbsuthmd7gi 472 9 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 472 10 differentiation differentiation NN work_zbi2knhp65ho5n7vbsuthmd7gi 472 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 473 1 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 473 2 2008 2008 CD work_zbi2knhp65ho5n7vbsuthmd7gi 473 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 473 4 4:947 4:947 CD work_zbi2knhp65ho5n7vbsuthmd7gi 473 5 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 473 6 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 473 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 473 8 PMID:18769161 PMID:18769161 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 473 9 47 47 CD work_zbi2knhp65ho5n7vbsuthmd7gi 473 10 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 474 1 Maggs Maggs NNP work_zbi2knhp65ho5n7vbsuthmd7gi 474 2 JL JL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 474 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 474 4 Tingle Tingle NNP work_zbi2knhp65ho5n7vbsuthmd7gi 474 5 MD MD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 474 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 474 7 Kitteringham Kitteringham NNP work_zbi2knhp65ho5n7vbsuthmd7gi 474 8 NR NR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 474 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 474 10 Park Park NNP work_zbi2knhp65ho5n7vbsuthmd7gi 474 11 BK BK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 474 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 475 1 Drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 475 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 475 3 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 475 4 conjugates conjugate NNS work_zbi2knhp65ho5n7vbsuthmd7gi 475 5 -- -- : work_zbi2knhp65ho5n7vbsuthmd7gi 475 6 XIV xiv NN work_zbi2knhp65ho5n7vbsuthmd7gi 475 7 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 476 1 Mechanisms mechanism NNS work_zbi2knhp65ho5n7vbsuthmd7gi 476 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 476 3 forma- forma- NN work_zbi2knhp65ho5n7vbsuthmd7gi 476 4 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 476 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 476 6 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 476 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 476 8 arylating arylate VBG work_zbi2knhp65ho5n7vbsuthmd7gi 476 9 intermediates intermediate NNS work_zbi2knhp65ho5n7vbsuthmd7gi 476 10 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 476 11 amodia- amodia- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 476 12 quine quine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 476 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 476 14 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 476 15 myelotoxin myelotoxin NN work_zbi2knhp65ho5n7vbsuthmd7gi 476 16 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 476 17 hepatotoxin hepatotoxin NN work_zbi2knhp65ho5n7vbsuthmd7gi 476 18 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 476 19 man man NN work_zbi2knhp65ho5n7vbsuthmd7gi 476 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 477 1 Biochem Biochem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 477 2 Pharmacol Pharmacol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 477 3 1988 1988 CD work_zbi2knhp65ho5n7vbsuthmd7gi 477 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 477 5 37:303 37:303 CD work_zbi2knhp65ho5n7vbsuthmd7gi 477 6 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 477 7 11 11 CD work_zbi2knhp65ho5n7vbsuthmd7gi 477 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 477 9 PMID:3342086 PMID:3342086 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 477 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 477 11 http:// http:// NNP work_zbi2knhp65ho5n7vbsuthmd7gi 477 12 dx.doi.org/10.1016/0006-2952(88)90733-2 dx.doi.org/10.1016/0006-2952(88)90733-2 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 477 13 48 48 CD work_zbi2knhp65ho5n7vbsuthmd7gi 477 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 478 1 Tafazoli Tafazoli NNP work_zbi2knhp65ho5n7vbsuthmd7gi 478 2 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 478 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 478 4 O’Brien O’Brien NNP work_zbi2knhp65ho5n7vbsuthmd7gi 478 5 PJ PJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 478 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 479 1 Amodiaquine Amodiaquine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 479 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 479 3 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 479 4 oxi- oxi- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 479 5 dative dative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 479 6 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 479 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 479 8 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 479 9 hepatocyte hepatocyte JJ work_zbi2knhp65ho5n7vbsuthmd7gi 479 10 inf inf NN work_zbi2knhp65ho5n7vbsuthmd7gi 479 11 lammation lammation NN work_zbi2knhp65ho5n7vbsuthmd7gi 479 12 model model NN work_zbi2knhp65ho5n7vbsuthmd7gi 479 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 480 1 Toxicology toxicology NN work_zbi2knhp65ho5n7vbsuthmd7gi 480 2 2009 2009 CD work_zbi2knhp65ho5n7vbsuthmd7gi 480 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 480 4 256:101 256:101 CD work_zbi2knhp65ho5n7vbsuthmd7gi 480 5 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 480 6 9 9 CD work_zbi2knhp65ho5n7vbsuthmd7gi 480 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 480 8 PMID:19059302 pmid:19059302 UH work_zbi2knhp65ho5n7vbsuthmd7gi 480 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 480 10 http://dx.doi.org/10.1016/j.tox.2008.11.006 http://dx.doi.org/10.1016/j.tox.2008.11.006 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 480 11 49 49 CD work_zbi2knhp65ho5n7vbsuthmd7gi 480 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 481 1 Mizushima Mizushima NNP work_zbi2knhp65ho5n7vbsuthmd7gi 481 2 N N NNP work_zbi2knhp65ho5n7vbsuthmd7gi 481 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 481 4 Yoshimori Yoshimori NNP work_zbi2knhp65ho5n7vbsuthmd7gi 481 5 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 481 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 481 7 Levine Levine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 481 8 B. B. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 482 1 Methods method NNS work_zbi2knhp65ho5n7vbsuthmd7gi 482 2 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 482 3 mammalian mammalian JJ work_zbi2knhp65ho5n7vbsuthmd7gi 482 4 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 482 5 research research NN work_zbi2knhp65ho5n7vbsuthmd7gi 482 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 483 1 Cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 483 2 2010 2010 CD work_zbi2knhp65ho5n7vbsuthmd7gi 483 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 483 4 140:313- 140:313- CD work_zbi2knhp65ho5n7vbsuthmd7gi 483 5 26 26 CD work_zbi2knhp65ho5n7vbsuthmd7gi 483 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 483 7 PMID:20144757 pmid:20144757 XX work_zbi2knhp65ho5n7vbsuthmd7gi 483 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 483 9 http://dx.doi.org/10.1016/j http://dx.doi.org/10.1016/j NNP work_zbi2knhp65ho5n7vbsuthmd7gi 483 10 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 484 1 cell.2010.01.028 cell.2010.01.028 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 484 2 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 484 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 485 1 Yamamoto Yamamoto NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 2 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 485 4 Tagawa Tagawa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 5 Y Y NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 485 7 Yoshimori Yoshimori NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 8 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 485 10 Moriyama Moriyama NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 11 Y Y NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 485 13 Masaki Masaki NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 14 R r NN work_zbi2knhp65ho5n7vbsuthmd7gi 485 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 485 16 Tashiro Tashiro NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 17 Y. Y. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 18 Bafilomycin Bafilomycin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 19 A1 A1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 20 prevents prevent VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 485 21 maturation maturation NN work_zbi2knhp65ho5n7vbsuthmd7gi 485 22 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 485 23 autophagic autophagic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 485 24 vacuoles vacuole NNS work_zbi2knhp65ho5n7vbsuthmd7gi 485 25 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 485 26 inhibiting inhibit VBG work_zbi2knhp65ho5n7vbsuthmd7gi 485 27 fusion fusion NN work_zbi2knhp65ho5n7vbsuthmd7gi 485 28 between between IN work_zbi2knhp65ho5n7vbsuthmd7gi 485 29 autophagosomes autophagosome NNS work_zbi2knhp65ho5n7vbsuthmd7gi 485 30 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 485 31 lysosomes lysosome NNS work_zbi2knhp65ho5n7vbsuthmd7gi 485 32 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 485 33 rat rat NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 34 hepatoma hepatoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 485 35 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 485 36 line line NN work_zbi2knhp65ho5n7vbsuthmd7gi 485 37 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 485 38 H-4-II h-4-ii JJ work_zbi2knhp65ho5n7vbsuthmd7gi 485 39 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 485 40 E e NN work_zbi2knhp65ho5n7vbsuthmd7gi 485 41 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 485 42 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 486 1 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 486 2 Struct Struct NNP work_zbi2knhp65ho5n7vbsuthmd7gi 486 3 Funct Funct NNP work_zbi2knhp65ho5n7vbsuthmd7gi 486 4 1998 1998 CD work_zbi2knhp65ho5n7vbsuthmd7gi 486 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 486 6 23:33 23:33 CD work_zbi2knhp65ho5n7vbsuthmd7gi 486 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 486 8 42 42 CD work_zbi2knhp65ho5n7vbsuthmd7gi 486 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 486 10 PMID:9639028 pmid:9639028 NN work_zbi2knhp65ho5n7vbsuthmd7gi 486 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 486 12 http://dx.doi http://dx.doi UH work_zbi2knhp65ho5n7vbsuthmd7gi 486 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 487 1 org/10.1247 org/10.1247 UH work_zbi2knhp65ho5n7vbsuthmd7gi 487 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 487 3 csf.23.33 csf.23.33 NN work_zbi2knhp65ho5n7vbsuthmd7gi 487 4 51 51 CD work_zbi2knhp65ho5n7vbsuthmd7gi 487 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 488 1 Marceau Marceau NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 2 F F NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 488 4 Bawolak Bawolak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 5 MT MT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 488 7 Lodge Lodge NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 8 R R NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 488 10 Bouthillier Bouthillier NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 11 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 488 13 Gagné Gagné NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 488 15 Henley Henley NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 16 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 488 18 Gaudreault Gaudreault NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 19 RC RC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 488 21 Morissette Morissette NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 22 G. G. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 23 Cation Cation NNP work_zbi2knhp65ho5n7vbsuthmd7gi 488 24 trapping trap VBG work_zbi2knhp65ho5n7vbsuthmd7gi 488 25 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 488 26 cellular cellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 488 27 acidic acidic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 488 28 compartments compartment NNS work_zbi2knhp65ho5n7vbsuthmd7gi 488 29 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 488 30 beyond beyond IN work_zbi2knhp65ho5n7vbsuthmd7gi 488 31 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 488 32 concept concept NN work_zbi2knhp65ho5n7vbsuthmd7gi 488 33 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 488 34 lysosomotropic lysosomotropic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 488 35 drugs drug NNS work_zbi2knhp65ho5n7vbsuthmd7gi 488 36 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 489 1 Toxicol Toxicol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 489 2 Appl Appl NNP work_zbi2knhp65ho5n7vbsuthmd7gi 489 3 Pharmacol Pharmacol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 489 4 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 489 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 489 6 259:1 259:1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 489 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 489 8 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 489 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 489 10 PMID:22198553 PMID:22198553 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 489 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 489 12 http://dx.doi.org/10.1016/j.taap.2011.12.004 http://dx.doi.org/10.1016/j.taap.2011.12.004 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 489 13 52 52 CD work_zbi2knhp65ho5n7vbsuthmd7gi 489 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 490 1 Homewood Homewood NNP work_zbi2knhp65ho5n7vbsuthmd7gi 490 2 CA CA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 490 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 490 4 Warhurst Warhurst NNP work_zbi2knhp65ho5n7vbsuthmd7gi 490 5 DC DC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 490 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 490 7 Peters Peters NNP work_zbi2knhp65ho5n7vbsuthmd7gi 490 8 W W NNP work_zbi2knhp65ho5n7vbsuthmd7gi 490 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 490 10 Baggaley Baggaley NNP work_zbi2knhp65ho5n7vbsuthmd7gi 490 11 VC VC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 490 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 491 1 Lysosomes Lysosomes NNP work_zbi2knhp65ho5n7vbsuthmd7gi 491 2 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 491 3 pH pH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 491 4 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 491 5 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 491 6 anti anti JJ work_zbi2knhp65ho5n7vbsuthmd7gi 491 7 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 491 8 malarial malarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 491 9 action action NN work_zbi2knhp65ho5n7vbsuthmd7gi 491 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 491 11 chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 491 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 492 1 Nature nature NN work_zbi2knhp65ho5n7vbsuthmd7gi 492 2 1972 1972 CD work_zbi2knhp65ho5n7vbsuthmd7gi 492 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 492 4 235:50 235:50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 492 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 492 6 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 492 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 492 8 PMID:4550396 PMID:4550396 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 492 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 492 10 http://dx.doi.org/10.1038/235050a0 http://dx.doi.org/10.1038/235050a0 NN work_zbi2knhp65ho5n7vbsuthmd7gi 492 11 53 53 CD work_zbi2knhp65ho5n7vbsuthmd7gi 492 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 493 1 Slater Slater NNP work_zbi2knhp65ho5n7vbsuthmd7gi 493 2 AF AF NNP work_zbi2knhp65ho5n7vbsuthmd7gi 493 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 494 1 Chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 494 2 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 494 3 mechanism mechanism NN work_zbi2knhp65ho5n7vbsuthmd7gi 494 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 494 5 drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 494 6 action action NN work_zbi2knhp65ho5n7vbsuthmd7gi 494 7 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 494 8 resistance resistance NN work_zbi2knhp65ho5n7vbsuthmd7gi 494 9 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 494 10 Plasmodium Plasmodium NNP work_zbi2knhp65ho5n7vbsuthmd7gi 494 11 falciparum falciparum NN work_zbi2knhp65ho5n7vbsuthmd7gi 494 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 495 1 Pharmacol Pharmacol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 495 2 Ther Ther NNP work_zbi2knhp65ho5n7vbsuthmd7gi 495 3 1993 1993 CD work_zbi2knhp65ho5n7vbsuthmd7gi 495 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 495 5 57:203 57:203 CD work_zbi2knhp65ho5n7vbsuthmd7gi 495 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 495 7 35 35 CD work_zbi2knhp65ho5n7vbsuthmd7gi 495 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 495 9 PMID:8361993 pmid:8361993 NN work_zbi2knhp65ho5n7vbsuthmd7gi 495 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 495 11 http:// http:// NNP work_zbi2knhp65ho5n7vbsuthmd7gi 495 12 dx.doi.org/10.1016/0163-7258(93)90056-J dx.doi.org/10.1016/0163-7258(93)90056-J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 495 13 54 54 CD work_zbi2knhp65ho5n7vbsuthmd7gi 495 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 496 1 Koike Koike NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 2 M M NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 496 4 Shibata Shibata NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 5 M M NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 496 7 Waguri Waguri NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 8 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 496 10 Yoshimura Yoshimura NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 11 K K NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 496 13 Tanida Tanida NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 14 I I NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 496 16 Kominami Kominami NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 17 E E NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 496 19 Gotow Gotow NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 20 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 496 22 Peters Peters NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 23 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 496 25 von von NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 26 Figura Figura NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 27 K K NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 28 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 496 29 Mizushima Mizushima NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 30 N N NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 31 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 496 32 et et NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 33 al al NNP work_zbi2knhp65ho5n7vbsuthmd7gi 496 34 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 497 1 Participation participation NN work_zbi2knhp65ho5n7vbsuthmd7gi 497 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 497 3 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 497 4 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 497 5 storage storage NN work_zbi2knhp65ho5n7vbsuthmd7gi 497 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 497 7 lysosomes lysosome NNS work_zbi2knhp65ho5n7vbsuthmd7gi 497 8 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 497 9 neurons neuron NNS work_zbi2knhp65ho5n7vbsuthmd7gi 497 10 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 497 11 mouse mouse NN work_zbi2knhp65ho5n7vbsuthmd7gi 497 12 models model NNS work_zbi2knhp65ho5n7vbsuthmd7gi 497 13 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 497 14 neuronal neuronal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 497 15 ceroid ceroid NN work_zbi2knhp65ho5n7vbsuthmd7gi 497 16 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 497 17 lipofuscinoses lipofuscinose NNS work_zbi2knhp65ho5n7vbsuthmd7gi 497 18 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 497 19 Batten Batten NNP work_zbi2knhp65ho5n7vbsuthmd7gi 497 20 disease disease NN work_zbi2knhp65ho5n7vbsuthmd7gi 497 21 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 497 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 498 1 Am Am NNP work_zbi2knhp65ho5n7vbsuthmd7gi 498 2 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 498 3 Pathol Pathol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 498 4 2005 2005 CD work_zbi2knhp65ho5n7vbsuthmd7gi 498 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 498 6 167:1713 167:1713 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 498 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 498 8 28 28 CD work_zbi2knhp65ho5n7vbsuthmd7gi 498 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 498 10 PMID:16314482 pmid:16314482 UH work_zbi2knhp65ho5n7vbsuthmd7gi 498 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 498 12 http:// http:// NNP work_zbi2knhp65ho5n7vbsuthmd7gi 498 13 dx.doi.org/10.1016/S0002-9440(10)61253-9 dx.doi.org/10.1016/S0002-9440(10)61253-9 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 498 14 55 55 CD work_zbi2knhp65ho5n7vbsuthmd7gi 498 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 499 1 Ha ha UH work_zbi2knhp65ho5n7vbsuthmd7gi 499 2 SD sd NN work_zbi2knhp65ho5n7vbsuthmd7gi 499 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 499 4 Ham Ham NNP work_zbi2knhp65ho5n7vbsuthmd7gi 499 5 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 499 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 499 7 Mogridge Mogridge NNP work_zbi2knhp65ho5n7vbsuthmd7gi 499 8 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 499 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 499 10 Saftig Saftig NNP work_zbi2knhp65ho5n7vbsuthmd7gi 499 11 P P NNP work_zbi2knhp65ho5n7vbsuthmd7gi 499 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 499 13 Lin Lin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 499 14 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 499 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 499 16 Kim Kim NNP work_zbi2knhp65ho5n7vbsuthmd7gi 499 17 SO SO NNP work_zbi2knhp65ho5n7vbsuthmd7gi 499 18 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 500 1 Cathepsin Cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 500 2 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 500 3 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 500 4 mediated mediate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 500 5 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 500 6 f f NNP work_zbi2knhp65ho5n7vbsuthmd7gi 500 7 lux lux NNP work_zbi2knhp65ho5n7vbsuthmd7gi 500 8 facilitates facilitate VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 500 9 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 500 10 anthrax anthrax NN work_zbi2knhp65ho5n7vbsuthmd7gi 500 11 toxin toxin NN work_zbi2knhp65ho5n7vbsuthmd7gi 500 12 receptor receptor NN work_zbi2knhp65ho5n7vbsuthmd7gi 500 13 2-mediated 2-mediated CD work_zbi2knhp65ho5n7vbsuthmd7gi 500 14 delivery delivery NN work_zbi2knhp65ho5n7vbsuthmd7gi 500 15 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 500 16 anthrax anthrax NN work_zbi2knhp65ho5n7vbsuthmd7gi 500 17 lethal lethal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 500 18 factor factor NN work_zbi2knhp65ho5n7vbsuthmd7gi 500 19 into into IN work_zbi2knhp65ho5n7vbsuthmd7gi 500 20 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 500 21 cytoplasm cytoplasm NN work_zbi2knhp65ho5n7vbsuthmd7gi 500 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 501 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 501 2 Biol Biol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 501 3 Chem Chem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 501 4 2010 2010 CD work_zbi2knhp65ho5n7vbsuthmd7gi 501 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 501 6 285:2120 285:2120 CD work_zbi2knhp65ho5n7vbsuthmd7gi 501 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 501 8 9 9 CD work_zbi2knhp65ho5n7vbsuthmd7gi 501 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 501 10 PMID:19858192 pmid:19858192 NN work_zbi2knhp65ho5n7vbsuthmd7gi 501 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 501 12 http://dx.doi http://dx.doi NN work_zbi2knhp65ho5n7vbsuthmd7gi 501 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 502 1 org/10.1074 org/10.1074 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 502 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 502 3 jbc jbc NNP work_zbi2knhp65ho5n7vbsuthmd7gi 502 4 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 502 5 M109.065813 m109.065813 UH work_zbi2knhp65ho5n7vbsuthmd7gi 502 6 56 56 CD work_zbi2knhp65ho5n7vbsuthmd7gi 502 7 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 503 1 Boya Boya NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 2 P P NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 503 4 Gonzalez Gonzalez NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 503 6 Polo Polo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 7 R R NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 8 A a NN work_zbi2knhp65ho5n7vbsuthmd7gi 503 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 503 10 Poncet poncet NN work_zbi2knhp65ho5n7vbsuthmd7gi 503 11 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 503 13 Andreau Andreau NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 14 K K NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 503 16 Vieira Vieira NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 17 HL HL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 503 19 Roumier Roumier NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 20 T T NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 503 22 Perfettini Perfettini NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 23 JL JL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 24 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 503 25 Kroemer Kroemer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 26 G. G. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 27 Mitochondrial Mitochondrial NNP work_zbi2knhp65ho5n7vbsuthmd7gi 503 28 membrane membrane NN work_zbi2knhp65ho5n7vbsuthmd7gi 503 29 permeabilization permeabilization NN work_zbi2knhp65ho5n7vbsuthmd7gi 503 30 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 503 31 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 503 32 critical critical JJ work_zbi2knhp65ho5n7vbsuthmd7gi 503 33 step step NN work_zbi2knhp65ho5n7vbsuthmd7gi 503 34 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 503 35 lysosome lysosome NN work_zbi2knhp65ho5n7vbsuthmd7gi 503 36 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 503 37 initiated initiate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 503 38 apoptosis apoptosis NN work_zbi2knhp65ho5n7vbsuthmd7gi 503 39 induced induce VBN work_zbi2knhp65ho5n7vbsuthmd7gi 503 40 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 503 41 hydroxychloroquine hydroxychloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 503 42 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 504 1 Oncogene oncogene NN work_zbi2knhp65ho5n7vbsuthmd7gi 504 2 2003 2003 CD work_zbi2knhp65ho5n7vbsuthmd7gi 504 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 504 4 22:3927- 22:3927- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 504 5 36 36 CD work_zbi2knhp65ho5n7vbsuthmd7gi 504 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 504 7 PMID:12813466 PMID:12813466 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 504 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 504 9 http://dx.doi.org/10.1038/ http://dx.doi.org/10.1038/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 504 10 sj.onc.1206622 sj.onc.1206622 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 504 11 57 57 CD work_zbi2knhp65ho5n7vbsuthmd7gi 504 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 505 1 Fantin fantin NN work_zbi2knhp65ho5n7vbsuthmd7gi 505 2 VR VR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 505 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 505 4 Berardi Berardi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 505 5 MJ MJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 505 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 505 7 Scorrano Scorrano NNP work_zbi2knhp65ho5n7vbsuthmd7gi 505 8 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 505 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 505 10 Korsmeyer Korsmeyer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 505 11 SJ SJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 505 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 505 13 Leder Leder NNP work_zbi2knhp65ho5n7vbsuthmd7gi 505 14 P. P. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 505 15 A a DT work_zbi2knhp65ho5n7vbsuthmd7gi 505 16 novel novel NN work_zbi2knhp65ho5n7vbsuthmd7gi 505 17 mitochondriotoxic mitochondriotoxic NN work_zbi2knhp65ho5n7vbsuthmd7gi 505 18 small small JJ work_zbi2knhp65ho5n7vbsuthmd7gi 505 19 molecule molecule NN work_zbi2knhp65ho5n7vbsuthmd7gi 505 20 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 505 21 selectively selectively RB work_zbi2knhp65ho5n7vbsuthmd7gi 505 22 inhibits inhibit VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 505 23 tumor tumor NN work_zbi2knhp65ho5n7vbsuthmd7gi 505 24 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 505 25 growth growth NN work_zbi2knhp65ho5n7vbsuthmd7gi 505 26 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 506 1 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 506 2 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 506 3 2002 2002 CD work_zbi2knhp65ho5n7vbsuthmd7gi 506 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 506 5 2:29 2:29 CD work_zbi2knhp65ho5n7vbsuthmd7gi 506 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 506 7 42 42 CD work_zbi2knhp65ho5n7vbsuthmd7gi 506 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 506 9 PMID:12150823 pmid:12150823 NN work_zbi2knhp65ho5n7vbsuthmd7gi 506 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 506 11 http://dx.doi http://dx.doi NN work_zbi2knhp65ho5n7vbsuthmd7gi 506 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 507 1 org/10.1016 org/10.1016 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 507 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 507 3 S1535 s1535 NN work_zbi2knhp65ho5n7vbsuthmd7gi 507 4 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 507 5 6108(02)00082-X 6108(02)00082-x NN work_zbi2knhp65ho5n7vbsuthmd7gi 507 6 58 58 CD work_zbi2knhp65ho5n7vbsuthmd7gi 507 7 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 508 1 Fantin fantin NN work_zbi2knhp65ho5n7vbsuthmd7gi 508 2 VR VR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 508 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 508 4 Leder Leder NNP work_zbi2knhp65ho5n7vbsuthmd7gi 508 5 P. P. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 508 6 Mitochondriotoxic Mitochondriotoxic NNP work_zbi2knhp65ho5n7vbsuthmd7gi 508 7 compounds compound VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 508 8 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 508 9 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 508 10 therapy therapy NN work_zbi2knhp65ho5n7vbsuthmd7gi 508 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 509 1 Oncogene oncogene NN work_zbi2knhp65ho5n7vbsuthmd7gi 509 2 2006 2006 CD work_zbi2knhp65ho5n7vbsuthmd7gi 509 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 509 4 25:4787- 25:4787- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 509 5 97 97 CD work_zbi2knhp65ho5n7vbsuthmd7gi 509 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 509 7 PMID:16892091 PMID:16892091 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 509 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 509 9 http://dx.doi.org/10.1038/ http://dx.doi.org/10.1038/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 509 10 sj.onc.1209599 sj.onc.1209599 CC work_zbi2knhp65ho5n7vbsuthmd7gi 509 11 59 59 CD work_zbi2knhp65ho5n7vbsuthmd7gi 509 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 510 1 Cabello Cabello NNP work_zbi2knhp65ho5n7vbsuthmd7gi 510 2 CM CM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 510 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 510 4 Lamore Lamore NNP work_zbi2knhp65ho5n7vbsuthmd7gi 510 5 SD SD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 510 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 510 7 Bair Bair NNP work_zbi2knhp65ho5n7vbsuthmd7gi 510 8 WB WB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 510 9 3rd 3rd NN work_zbi2knhp65ho5n7vbsuthmd7gi 510 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 510 11 Davis Davis NNP work_zbi2knhp65ho5n7vbsuthmd7gi 510 12 AL AL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 510 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 510 14 Azimian azimian JJ work_zbi2knhp65ho5n7vbsuthmd7gi 510 15 SM SM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 510 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 510 17 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 510 18 GT GT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 510 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 511 1 DCPIP DCPIP NNP work_zbi2knhp65ho5n7vbsuthmd7gi 511 2 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 511 3 2,6-dichloro- 2,6-dichloro- NN work_zbi2knhp65ho5n7vbsuthmd7gi 511 4 phenolindophenol phenolindophenol NN work_zbi2knhp65ho5n7vbsuthmd7gi 511 5 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 511 6 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 511 7 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 511 8 genotype genotype NN work_zbi2knhp65ho5n7vbsuthmd7gi 511 9 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 511 10 directed direct VBN work_zbi2knhp65ho5n7vbsuthmd7gi 511 11 redox redox NN work_zbi2knhp65ho5n7vbsuthmd7gi 511 12 che- che- RB work_zbi2knhp65ho5n7vbsuthmd7gi 511 13 motherapeutic motherapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 511 14 targeting target VBG work_zbi2knhp65ho5n7vbsuthmd7gi 511 15 NQO1 nqo1 NN work_zbi2knhp65ho5n7vbsuthmd7gi 511 16 * * NFP work_zbi2knhp65ho5n7vbsuthmd7gi 511 17 2 2 CD work_zbi2knhp65ho5n7vbsuthmd7gi 511 18 breast breast NN work_zbi2knhp65ho5n7vbsuthmd7gi 511 19 carcinoma carcinoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 511 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 512 1 Free free JJ work_zbi2knhp65ho5n7vbsuthmd7gi 512 2 Radic radic NN work_zbi2knhp65ho5n7vbsuthmd7gi 512 3 Res res NN work_zbi2knhp65ho5n7vbsuthmd7gi 512 4 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 512 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 512 6 45:276 45:276 CD work_zbi2knhp65ho5n7vbsuthmd7gi 512 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 512 8 92 92 CD work_zbi2knhp65ho5n7vbsuthmd7gi 512 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 512 10 PMID:21034357 PMID:21034357 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 512 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 512 12 http://dx.doi.org/10.3109/10715762.2010.526766 http://dx.doi.org/10.3109/10715762.2010.526766 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 512 13 60 60 CD work_zbi2knhp65ho5n7vbsuthmd7gi 512 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 513 1 Gartel Gartel NNP work_zbi2knhp65ho5n7vbsuthmd7gi 513 2 AL AL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 513 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 513 4 Radhakrishnan Radhakrishnan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 513 5 SK SK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 513 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 514 1 Lost lose VBN work_zbi2knhp65ho5n7vbsuthmd7gi 514 2 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 514 3 transcrip- transcrip- FW work_zbi2knhp65ho5n7vbsuthmd7gi 514 4 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 514 5 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 514 6 p21 p21 NN work_zbi2knhp65ho5n7vbsuthmd7gi 514 7 repression repression NN work_zbi2knhp65ho5n7vbsuthmd7gi 514 8 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 514 9 mechanisms mechanism NNS work_zbi2knhp65ho5n7vbsuthmd7gi 514 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 514 11 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 514 12 consequences consequence NNS work_zbi2knhp65ho5n7vbsuthmd7gi 514 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 515 1 Cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 515 2 Res Res NNP work_zbi2knhp65ho5n7vbsuthmd7gi 515 3 2005 2005 CD work_zbi2knhp65ho5n7vbsuthmd7gi 515 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 515 5 65:3980 65:3980 CD work_zbi2knhp65ho5n7vbsuthmd7gi 515 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 515 7 5 5 CD work_zbi2knhp65ho5n7vbsuthmd7gi 515 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 515 9 PMID:15899785 PMID:15899785 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 515 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 515 11 http://dx.doi.org/10.1158/0008-5472.CAN-04-3995 http://dx.doi.org/10.1158/0008-5472.can-04-3995 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 515 12 61 61 CD work_zbi2knhp65ho5n7vbsuthmd7gi 515 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 516 1 Davis Davis NNP work_zbi2knhp65ho5n7vbsuthmd7gi 516 2 AL AL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 516 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 516 4 Cabello Cabello NNP work_zbi2knhp65ho5n7vbsuthmd7gi 516 5 CM CM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 516 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 516 7 Qiao Qiao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 516 8 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 516 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 516 10 Azimian Azimian NNP work_zbi2knhp65ho5n7vbsuthmd7gi 516 11 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 516 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 516 13 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 516 14 GT GT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 516 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 517 1 Phenotypic phenotypic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 517 2 identification identification NN work_zbi2knhp65ho5n7vbsuthmd7gi 517 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 517 4 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 517 5 redox redox NNP work_zbi2knhp65ho5n7vbsuthmd7gi 517 6 dye dye NN work_zbi2knhp65ho5n7vbsuthmd7gi 517 7 meth- meth- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 517 8 ylene ylene NNP work_zbi2knhp65ho5n7vbsuthmd7gi 517 9 blue blue NNP work_zbi2knhp65ho5n7vbsuthmd7gi 517 10 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 517 11 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 517 12 antagonist antagonist NN work_zbi2knhp65ho5n7vbsuthmd7gi 517 13 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 517 14 heat heat NN work_zbi2knhp65ho5n7vbsuthmd7gi 517 15 shock shock NN work_zbi2knhp65ho5n7vbsuthmd7gi 517 16 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 517 17 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 517 18 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 517 19 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 517 20 metastatic metastatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 517 21 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 517 22 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 517 23 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 518 1 Int Int NNP work_zbi2knhp65ho5n7vbsuthmd7gi 518 2 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 518 3 Mol Mol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 518 4 Sci Sci NNP work_zbi2knhp65ho5n7vbsuthmd7gi 518 5 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 518 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 518 7 14:4185 14:4185 CD work_zbi2knhp65ho5n7vbsuthmd7gi 518 8 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 518 9 202 202 CD work_zbi2knhp65ho5n7vbsuthmd7gi 518 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 518 11 PMID:23429201 pmid:23429201 NN work_zbi2knhp65ho5n7vbsuthmd7gi 518 12 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 518 13 http://dx.doi.org/10.3390/ijms14024185 http://dx.doi.org/10.3390/ijms14024185 IN work_zbi2knhp65ho5n7vbsuthmd7gi 518 14 62 62 CD work_zbi2knhp65ho5n7vbsuthmd7gi 518 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 519 1 Qiao Qiao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 2 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 519 4 Lamore Lamore NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 5 SD SD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 519 7 Cabello Cabello NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 8 CM CM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 519 10 Lesson Lesson NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 11 JL JL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 519 13 Muñoz Muñoz NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 519 15 Rodriguez Rodriguez NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 16 JL JL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 519 18 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 19 GT GT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 519 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 520 1 Thiostrepton Thiostrepton NNP work_zbi2knhp65ho5n7vbsuthmd7gi 520 2 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 520 3 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 520 4 inducer inducer NN work_zbi2knhp65ho5n7vbsuthmd7gi 520 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 520 6 oxidative oxidative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 520 7 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 520 8 proteotoxic proteotoxic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 520 9 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 520 10 that that IN work_zbi2knhp65ho5n7vbsuthmd7gi 520 11 impairs impairs VBP work_zbi2knhp65ho5n7vbsuthmd7gi 520 12 viability viability NN work_zbi2knhp65ho5n7vbsuthmd7gi 520 13 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 520 14 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 520 15 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 520 16 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 520 17 but but CC work_zbi2knhp65ho5n7vbsuthmd7gi 520 18 not not RB work_zbi2knhp65ho5n7vbsuthmd7gi 520 19 primary primary JJ work_zbi2knhp65ho5n7vbsuthmd7gi 520 20 melanocytes melanocyte NNS work_zbi2knhp65ho5n7vbsuthmd7gi 520 21 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 521 1 Biochem Biochem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 521 2 Pharmacol Pharmacol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 521 3 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 521 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 521 5 83:1229 83:1229 CD work_zbi2knhp65ho5n7vbsuthmd7gi 521 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 521 7 40 40 CD work_zbi2knhp65ho5n7vbsuthmd7gi 521 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 521 9 PMID:22321511 pmid:22321511 UH work_zbi2knhp65ho5n7vbsuthmd7gi 521 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 521 11 http://dx.doi http://dx.doi UH work_zbi2knhp65ho5n7vbsuthmd7gi 521 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 522 1 org/10.1016 org/10.1016 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 522 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 522 3 j.bcp.2012.01.027 j.bcp.2012.01.027 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 522 4 63 63 CD work_zbi2knhp65ho5n7vbsuthmd7gi 522 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 523 1 Luo Luo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 523 2 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 523 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 523 4 Solimini Solimini NNP work_zbi2knhp65ho5n7vbsuthmd7gi 523 5 NL NL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 523 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 523 7 Elledge Elledge NNP work_zbi2knhp65ho5n7vbsuthmd7gi 523 8 SJ SJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 523 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 524 1 Principles principle NNS work_zbi2knhp65ho5n7vbsuthmd7gi 524 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 524 3 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 524 4 therapy therapy NN work_zbi2knhp65ho5n7vbsuthmd7gi 524 5 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 524 6 oncogene oncogene NN work_zbi2knhp65ho5n7vbsuthmd7gi 524 7 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 524 8 non non JJ work_zbi2knhp65ho5n7vbsuthmd7gi 524 9 - - JJ work_zbi2knhp65ho5n7vbsuthmd7gi 524 10 oncogene oncogene JJ work_zbi2knhp65ho5n7vbsuthmd7gi 524 11 addiction addiction NN work_zbi2knhp65ho5n7vbsuthmd7gi 524 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 525 1 Cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 525 2 2009 2009 CD work_zbi2knhp65ho5n7vbsuthmd7gi 525 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 525 4 136:823 136:823 CD work_zbi2knhp65ho5n7vbsuthmd7gi 525 5 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 525 6 37 37 CD work_zbi2knhp65ho5n7vbsuthmd7gi 525 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 525 8 PMID:19269363 PMID:19269363 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 525 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 525 10 http://dx.doi http://dx.doi UH work_zbi2knhp65ho5n7vbsuthmd7gi 525 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 526 1 org/10.1016 org/10.1016 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 526 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 526 3 j.cell.2009.02.024 j.cell.2009.02.024 $ work_zbi2knhp65ho5n7vbsuthmd7gi 526 4 64 64 CD work_zbi2knhp65ho5n7vbsuthmd7gi 526 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 527 1 Qiao Qiao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 527 2 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 527 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 527 4 Cabello Cabello NNP work_zbi2knhp65ho5n7vbsuthmd7gi 527 5 CM CM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 527 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 527 7 Lamore Lamore NNP work_zbi2knhp65ho5n7vbsuthmd7gi 527 8 SD SD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 527 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 527 10 Lesson Lesson NNP work_zbi2knhp65ho5n7vbsuthmd7gi 527 11 JL JL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 527 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 527 13 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 527 14 GT GT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 527 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 528 1 D d JJ work_zbi2knhp65ho5n7vbsuthmd7gi 528 2 - - : work_zbi2knhp65ho5n7vbsuthmd7gi 528 3 Penicillamine Penicillamine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 528 4 targets target NNS work_zbi2knhp65ho5n7vbsuthmd7gi 528 5 metastatic metastatic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 528 6 melanoma melanoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 528 7 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 528 8 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 528 9 induction induction NN work_zbi2knhp65ho5n7vbsuthmd7gi 528 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 528 11 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 528 12 unfolded unfolded NNP work_zbi2knhp65ho5n7vbsuthmd7gi 528 13 pro- pro- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 528 14 tein tein NNP work_zbi2knhp65ho5n7vbsuthmd7gi 528 15 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 528 16 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 528 17 UPR UPR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 528 18 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 528 19 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 528 20 Noxa Noxa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 528 21 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 528 22 PMAIP1)-dependent pmaip1)-dependent CD work_zbi2knhp65ho5n7vbsuthmd7gi 528 23 mitochondrial mitochondrial NN work_zbi2knhp65ho5n7vbsuthmd7gi 528 24 apoptosis apoptosis NN work_zbi2knhp65ho5n7vbsuthmd7gi 528 25 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 529 1 Apoptosis Apoptosis NNP work_zbi2knhp65ho5n7vbsuthmd7gi 529 2 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 529 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 529 4 17:1079- 17:1079- CD work_zbi2knhp65ho5n7vbsuthmd7gi 529 5 94 94 CD work_zbi2knhp65ho5n7vbsuthmd7gi 529 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 529 7 PMID:22843330 pmid:22843330 NN work_zbi2knhp65ho5n7vbsuthmd7gi 529 8 ; ; , work_zbi2knhp65ho5n7vbsuthmd7gi 529 9 http://dx.doi.org/10.1007/ http://dx.doi.org/10.1007/ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 529 10 s10495 s10495 NN work_zbi2knhp65ho5n7vbsuthmd7gi 529 11 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 529 12 012 012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 529 13 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 529 14 0746-x 0746-x NNP work_zbi2knhp65ho5n7vbsuthmd7gi 529 15 65 65 CD work_zbi2knhp65ho5n7vbsuthmd7gi 529 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 530 1 Cabello Cabello NNP work_zbi2knhp65ho5n7vbsuthmd7gi 530 2 CM CM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 530 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 530 4 Bair Bair NNP work_zbi2knhp65ho5n7vbsuthmd7gi 530 5 WB WB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 530 6 3rd 3rd NN work_zbi2knhp65ho5n7vbsuthmd7gi 530 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 530 8 Ley Ley NNP work_zbi2knhp65ho5n7vbsuthmd7gi 530 9 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 530 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 530 11 Lamore Lamore NNP work_zbi2knhp65ho5n7vbsuthmd7gi 530 12 SD SD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 530 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 530 14 Azimian Azimian NNP work_zbi2knhp65ho5n7vbsuthmd7gi 530 15 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 530 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 530 17 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 530 18 GT GT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 530 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 531 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 531 2 experimental experimental JJ work_zbi2knhp65ho5n7vbsuthmd7gi 531 3 che- che- DT work_zbi2knhp65ho5n7vbsuthmd7gi 531 4 motherapeutic motherapeutic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 531 5 N6-furfuryladenosine N6-furfuryladenosine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 531 6 ( ( -LRB- work_zbi2knhp65ho5n7vbsuthmd7gi 531 7 kinetin- kinetin- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 531 8 riboside riboside NN work_zbi2knhp65ho5n7vbsuthmd7gi 531 9 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 531 10 induces induce VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 531 11 rapid rapid JJ work_zbi2knhp65ho5n7vbsuthmd7gi 531 12 ATP atp NN work_zbi2knhp65ho5n7vbsuthmd7gi 531 13 depletion depletion NN work_zbi2knhp65ho5n7vbsuthmd7gi 531 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 531 15 genotoxic genotoxic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 531 16 stress stress NN work_zbi2knhp65ho5n7vbsuthmd7gi 531 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 531 18 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 531 19 CDKN1A(p21 CDKN1A(p21 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 531 20 ) ) -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 531 21 upregulation upregulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 531 22 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 531 23 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 531 24 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 531 25 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 531 26 lines line NNS work_zbi2knhp65ho5n7vbsuthmd7gi 531 27 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 532 1 Biochem Biochem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 532 2 Pharmacol Pharmacol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 532 3 2009 2009 CD work_zbi2knhp65ho5n7vbsuthmd7gi 532 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 532 5 77:1125- 77:1125- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 532 6 38 38 CD work_zbi2knhp65ho5n7vbsuthmd7gi 532 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 532 8 PMID:19186174 PMID:19186174 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 532 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 532 10 http://dx.doi.org/10.1016/j http://dx.doi.org/10.1016/j NNP work_zbi2knhp65ho5n7vbsuthmd7gi 532 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 533 1 bcp.2008.12.002 bcp.2008.12.002 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 533 2 66 66 CD work_zbi2knhp65ho5n7vbsuthmd7gi 533 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 534 1 Warfel Warfel NNP work_zbi2knhp65ho5n7vbsuthmd7gi 534 2 NA NA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 534 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 534 4 El El NNP work_zbi2knhp65ho5n7vbsuthmd7gi 534 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 534 6 Deiry Deiry NNP work_zbi2knhp65ho5n7vbsuthmd7gi 534 7 WS WS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 534 8 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 535 1 p21WAF1 p21WAF1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 535 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 535 3 tumouri- tumouri- NN work_zbi2knhp65ho5n7vbsuthmd7gi 535 4 genesis genesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 535 5 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 535 6 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 535 7 years year NNS work_zbi2knhp65ho5n7vbsuthmd7gi 535 8 after after IN work_zbi2knhp65ho5n7vbsuthmd7gi 535 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 536 1 Curr Curr NNP work_zbi2knhp65ho5n7vbsuthmd7gi 536 2 Opin Opin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 536 3 Oncol Oncol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 536 4 2013 2013 CD work_zbi2knhp65ho5n7vbsuthmd7gi 536 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 536 6 25:52- 25:52- CD work_zbi2knhp65ho5n7vbsuthmd7gi 536 7 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 536 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 536 9 PMID:23159848 PMID:23159848 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 536 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 536 11 http://dx.doi.org/10.1097/ http://dx.doi.org/10.1097/ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 536 12 CCO.0b013e32835b639e CCO.0b013e32835b639e NNP work_zbi2knhp65ho5n7vbsuthmd7gi 536 13 67 67 CD work_zbi2knhp65ho5n7vbsuthmd7gi 536 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 537 1 Ma Ma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 2 Y Y NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 537 4 Kurtyka Kurtyka NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 5 CA CA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 537 7 Boyapalle Boyapalle NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 8 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 537 10 Sung Sung NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 11 SS SS NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 537 13 Lawrence Lawrence NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 14 H H NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 537 16 Guida Guida NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 17 W W NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 537 19 Cress Cress NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 20 WD WD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 537 21 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 538 1 A a DT work_zbi2knhp65ho5n7vbsuthmd7gi 538 2 small small JJ work_zbi2knhp65ho5n7vbsuthmd7gi 538 3 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 538 4 molecule molecule NN work_zbi2knhp65ho5n7vbsuthmd7gi 538 5 E2F E2F NNP work_zbi2knhp65ho5n7vbsuthmd7gi 538 6 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 538 7 blocks block NNS work_zbi2knhp65ho5n7vbsuthmd7gi 538 8 growth growth NN work_zbi2knhp65ho5n7vbsuthmd7gi 538 9 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 538 10 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 538 11 melanoma melanoma NNP work_zbi2knhp65ho5n7vbsuthmd7gi 538 12 culture culture NN work_zbi2knhp65ho5n7vbsuthmd7gi 538 13 model model NN work_zbi2knhp65ho5n7vbsuthmd7gi 538 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 539 1 Cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 539 2 Res Res NNP work_zbi2knhp65ho5n7vbsuthmd7gi 539 3 2008 2008 CD work_zbi2knhp65ho5n7vbsuthmd7gi 539 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 539 5 68:6292 68:6292 CD work_zbi2knhp65ho5n7vbsuthmd7gi 539 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 539 7 9 9 CD work_zbi2knhp65ho5n7vbsuthmd7gi 539 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 539 9 PMID:18676853 PMID:18676853 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 539 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 539 11 http://dx.doi.org/10.1158/0008-5472.CAN-08-0121 http://dx.doi.org/10.1158/0008-5472.can-08-0121 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 539 12 68 68 CD work_zbi2knhp65ho5n7vbsuthmd7gi 539 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 540 1 DeGregori DeGregori NNP work_zbi2knhp65ho5n7vbsuthmd7gi 540 2 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 540 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 540 4 Johnson Johnson NNP work_zbi2knhp65ho5n7vbsuthmd7gi 540 5 DG DG NNP work_zbi2knhp65ho5n7vbsuthmd7gi 540 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 541 1 Distinct distinct JJ work_zbi2knhp65ho5n7vbsuthmd7gi 541 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 541 3 Overlapping Overlapping NNP work_zbi2knhp65ho5n7vbsuthmd7gi 541 4 Roles Roles NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 541 5 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 541 6 E2F E2F NNP work_zbi2knhp65ho5n7vbsuthmd7gi 541 7 Family Family NNP work_zbi2knhp65ho5n7vbsuthmd7gi 541 8 Members Members NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 541 9 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 541 10 Transcription Transcription NNP work_zbi2knhp65ho5n7vbsuthmd7gi 541 11 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 541 12 Proliferation Proliferation NNP work_zbi2knhp65ho5n7vbsuthmd7gi 541 13 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 541 14 Apoptosis Apoptosis NNP work_zbi2knhp65ho5n7vbsuthmd7gi 541 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 542 1 Curr Curr NNP work_zbi2knhp65ho5n7vbsuthmd7gi 542 2 Mol Mol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 542 3 Med Med NNP work_zbi2knhp65ho5n7vbsuthmd7gi 542 4 2006 2006 CD work_zbi2knhp65ho5n7vbsuthmd7gi 542 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 542 6 6:739 6:739 CD work_zbi2knhp65ho5n7vbsuthmd7gi 542 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 542 8 48 48 CD work_zbi2knhp65ho5n7vbsuthmd7gi 542 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 542 10 PMID:17100600 pmid:17100600 RB work_zbi2knhp65ho5n7vbsuthmd7gi 542 11 69 69 CD work_zbi2knhp65ho5n7vbsuthmd7gi 542 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 543 1 Biswas Biswas NNP work_zbi2knhp65ho5n7vbsuthmd7gi 543 2 AK AK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 543 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 543 4 Johnson Johnson NNP work_zbi2knhp65ho5n7vbsuthmd7gi 543 5 DG DG NNP work_zbi2knhp65ho5n7vbsuthmd7gi 543 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 544 1 Transcriptional transcriptional JJ work_zbi2knhp65ho5n7vbsuthmd7gi 544 2 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 544 3 nontranscriptional nontranscriptional JJ work_zbi2knhp65ho5n7vbsuthmd7gi 544 4 functions function NNS work_zbi2knhp65ho5n7vbsuthmd7gi 544 5 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 544 6 E2F1 E2F1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 544 7 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 544 8 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 544 9 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 544 10 DNA dna NN work_zbi2knhp65ho5n7vbsuthmd7gi 544 11 damage damage NN work_zbi2knhp65ho5n7vbsuthmd7gi 544 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 545 1 Cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 545 2 Res Res NNP work_zbi2knhp65ho5n7vbsuthmd7gi 545 3 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 545 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 545 5 72:13 72:13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 545 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 545 7 7 7 CD work_zbi2knhp65ho5n7vbsuthmd7gi 545 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 545 9 PMID:22180494 pmid:22180494 NN work_zbi2knhp65ho5n7vbsuthmd7gi 545 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 545 11 http://dx.doi.org/10.1158/0008- http://dx.doi.org/10.1158/0008- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 545 12 5472.CAN-11 5472.can-11 CD work_zbi2knhp65ho5n7vbsuthmd7gi 545 13 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 545 14 2196 2196 CD work_zbi2knhp65ho5n7vbsuthmd7gi 545 15 70 70 CD work_zbi2knhp65ho5n7vbsuthmd7gi 545 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 546 1 Samant samant JJ work_zbi2knhp65ho5n7vbsuthmd7gi 546 2 GV GV NNP work_zbi2knhp65ho5n7vbsuthmd7gi 546 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 546 4 Wali Wali NNP work_zbi2knhp65ho5n7vbsuthmd7gi 546 5 VB VB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 546 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 546 7 Sylvester Sylvester NNP work_zbi2knhp65ho5n7vbsuthmd7gi 546 8 PW PW NNP work_zbi2knhp65ho5n7vbsuthmd7gi 546 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 547 1 Anti- Anti- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 547 2 proliferative proliferative JJ work_zbi2knhp65ho5n7vbsuthmd7gi 547 3 effects effect NNS work_zbi2knhp65ho5n7vbsuthmd7gi 547 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 547 5 gamma gamma NN work_zbi2knhp65ho5n7vbsuthmd7gi 547 6 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 547 7 tocotrienol tocotrienol NN work_zbi2knhp65ho5n7vbsuthmd7gi 547 8 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 547 9 mammary mammary JJ work_zbi2knhp65ho5n7vbsuthmd7gi 547 10 tumour tumour NN work_zbi2knhp65ho5n7vbsuthmd7gi 547 11 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 547 12 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 547 13 associated associate VBN work_zbi2knhp65ho5n7vbsuthmd7gi 547 14 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 547 15 sup- sup- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 547 16 pression pression NN work_zbi2knhp65ho5n7vbsuthmd7gi 547 17 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 547 18 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 547 19 cycle cycle NN work_zbi2knhp65ho5n7vbsuthmd7gi 547 20 progression progression NN work_zbi2knhp65ho5n7vbsuthmd7gi 547 21 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 548 1 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 548 2 Prolif Prolif NNP work_zbi2knhp65ho5n7vbsuthmd7gi 548 3 2010 2010 CD work_zbi2knhp65ho5n7vbsuthmd7gi 548 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 548 5 43:77 43:77 CD work_zbi2knhp65ho5n7vbsuthmd7gi 548 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 548 7 83 83 CD work_zbi2knhp65ho5n7vbsuthmd7gi 548 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 548 9 PMID:19922488 PMID:19922488 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 548 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 548 11 http://dx.doi http://dx.doi NN work_zbi2knhp65ho5n7vbsuthmd7gi 548 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 549 1 org/10.1111 org/10.1111 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 549 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 549 3 j.1365 j.1365 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 549 4 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 549 5 2184.2009.00657.x 2184.2009.00657.x CD work_zbi2knhp65ho5n7vbsuthmd7gi 549 6 71 71 CD work_zbi2knhp65ho5n7vbsuthmd7gi 549 7 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 550 1 Macdonald Macdonald NNP work_zbi2knhp65ho5n7vbsuthmd7gi 550 2 JI JI NNP work_zbi2knhp65ho5n7vbsuthmd7gi 550 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 550 4 Dick Dick NNP work_zbi2knhp65ho5n7vbsuthmd7gi 550 5 FA FA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 550 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 551 1 Posttranslational posttranslational JJ work_zbi2knhp65ho5n7vbsuthmd7gi 551 2 modi- modi- NN work_zbi2knhp65ho5n7vbsuthmd7gi 551 3 fications fication NNS work_zbi2knhp65ho5n7vbsuthmd7gi 551 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 551 5 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 551 6 retinoblastoma retinoblastoma NN work_zbi2knhp65ho5n7vbsuthmd7gi 551 7 tumor tumor NN work_zbi2knhp65ho5n7vbsuthmd7gi 551 8 suppressor suppressor NN work_zbi2knhp65ho5n7vbsuthmd7gi 551 9 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 551 10 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 551 11 determinants determinant NNS work_zbi2knhp65ho5n7vbsuthmd7gi 551 12 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 551 13 function function NN work_zbi2knhp65ho5n7vbsuthmd7gi 551 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 552 1 Genes Genes NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 552 2 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 552 3 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 552 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 552 5 3:619 3:619 CD work_zbi2knhp65ho5n7vbsuthmd7gi 552 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 552 7 33 33 CD work_zbi2knhp65ho5n7vbsuthmd7gi 552 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 552 9 PMID:23634251 PMID:23634251 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 552 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 552 11 http://dx.doi http://dx.doi NN work_zbi2knhp65ho5n7vbsuthmd7gi 552 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 553 1 org/10.1177/1947601912473305 org/10.1177/1947601912473305 NFP work_zbi2knhp65ho5n7vbsuthmd7gi 553 2 72 72 CD work_zbi2knhp65ho5n7vbsuthmd7gi 553 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 554 1 Wibo Wibo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 554 2 M M NNP work_zbi2knhp65ho5n7vbsuthmd7gi 554 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 554 4 Poole Poole NNP work_zbi2knhp65ho5n7vbsuthmd7gi 554 5 B. B. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 555 1 Protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 555 2 degradation degradation NN work_zbi2knhp65ho5n7vbsuthmd7gi 555 3 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 555 4 cultured cultured JJ work_zbi2knhp65ho5n7vbsuthmd7gi 555 5 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 555 6 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 556 1 II ii CD work_zbi2knhp65ho5n7vbsuthmd7gi 556 2 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 557 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 557 2 uptake uptake NN work_zbi2knhp65ho5n7vbsuthmd7gi 557 3 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 557 4 chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 557 5 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 557 6 rat rat NN work_zbi2knhp65ho5n7vbsuthmd7gi 557 7 fibro- fibro- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 557 8 blasts blast NNS work_zbi2knhp65ho5n7vbsuthmd7gi 557 9 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 557 10 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 557 11 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 557 12 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 557 13 cellular cellular JJ work_zbi2knhp65ho5n7vbsuthmd7gi 557 14 protein protein NN work_zbi2knhp65ho5n7vbsuthmd7gi 557 15 degrada- degrada- AFX work_zbi2knhp65ho5n7vbsuthmd7gi 557 16 tion tion NN work_zbi2knhp65ho5n7vbsuthmd7gi 557 17 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 557 18 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 557 19 B1 B1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 557 20 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 558 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 558 2 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 558 3 Biol Biol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 558 4 1974 1974 CD work_zbi2knhp65ho5n7vbsuthmd7gi 558 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 558 6 63:430 63:430 CD work_zbi2knhp65ho5n7vbsuthmd7gi 558 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 558 8 40 40 CD work_zbi2knhp65ho5n7vbsuthmd7gi 558 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 558 10 PMID:4607946 PMID:4607946 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 558 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 558 12 http://dx.doi.org/10.1083/ http://dx.doi.org/10.1083/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 558 13 jcb.63.2.430 jcb.63.2.430 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 558 14 73 73 CD work_zbi2knhp65ho5n7vbsuthmd7gi 558 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 559 1 Klionsky Klionsky NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 2 DJ DJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 559 4 Abdalla Abdalla NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 5 FC FC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 559 7 Abeliovich Abeliovich NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 8 H H NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 559 10 Abraham Abraham NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 11 RT RT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 559 13 Acevedo Acevedo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 559 15 Arozena Arozena NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 16 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 559 18 Adeli Adeli NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 19 K K NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 559 21 Agholme Agholme NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 22 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 559 24 Agnello Agnello NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 25 M M NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 559 27 Agostinis Agostinis NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 28 P P NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 29 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 559 30 Aguirre Aguirre NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 31 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 559 32 Ghiso Ghiso NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 33 JA JA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 34 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 559 35 et et NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 36 al al NNP work_zbi2knhp65ho5n7vbsuthmd7gi 559 37 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 560 1 Guidelines guideline NNS work_zbi2knhp65ho5n7vbsuthmd7gi 560 2 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 560 3 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 560 4 use use NN work_zbi2knhp65ho5n7vbsuthmd7gi 560 5 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 560 6 interpretation interpretation NN work_zbi2knhp65ho5n7vbsuthmd7gi 560 7 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 560 8 assays assay NNS work_zbi2knhp65ho5n7vbsuthmd7gi 560 9 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 560 10 monitoring monitor VBG work_zbi2knhp65ho5n7vbsuthmd7gi 560 11 autophagy autophagy NN work_zbi2knhp65ho5n7vbsuthmd7gi 560 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 561 1 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 2 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 561 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 561 4 8:445- 8:445- CD work_zbi2knhp65ho5n7vbsuthmd7gi 561 5 544 544 CD work_zbi2knhp65ho5n7vbsuthmd7gi 561 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 561 7 PMID:22966490 PMID:22966490 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 561 9 http://dx.doi.org/10.4161/ http://dx.doi.org/10.4161/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 561 10 auto.19496 auto.19496 UH work_zbi2knhp65ho5n7vbsuthmd7gi 561 11 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21325076&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21325076&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 12 http://dx.doi.org/10.1158/1078-0432.CCR-10-2372 http://dx.doi.org/10.1158/1078-0432.CCR-10-2372 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 561 13 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21720400&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21720400&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 14 http://dx.doi.org/10.1038/nrd3482 http://dx.doi.org/10.1038/nrd3482 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 15 http://dx.doi.org/10.1038/nrd3482 http://dx.doi.org/10.1038/nrd3482 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 16 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23437349&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23437349&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 17 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23437349&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23437349&dopt=abstract FW work_zbi2knhp65ho5n7vbsuthmd7gi 561 18 http://dx.doi.org/10.1371/journal.pone.0057236 http://dx.doi.org/10.1371/journal.pone.0057236 PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 561 19 http://dx.doi.org/10.1371/journal.pone.0057236 http://dx.doi.org/10.1371/journal.pone.0057236 NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 20 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21547369&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21547369&dopt=abstract NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 21 http://dx.doi.org/10.1007/s10637-011-9676-7 http://dx.doi.org/10.1007/s10637-011-9676-7 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 22 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19496700&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19496700&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 23 http://dx.doi.org/10.1089/ars.2009.2541 http://dx.doi.org/10.1089/ars.2009.2541 FW work_zbi2knhp65ho5n7vbsuthmd7gi 561 24 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19881520&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19881520&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 25 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19881520&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19881520&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 26 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22458860&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22458860&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 27 http://dx.doi.org/10.1186/1475-2875-11-97 http://dx.doi.org/10.1186/1475-2875-11-97 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 28 http://dx.doi.org/10.1186/1475-2875-11-97 http://dx.doi.org/10.1186/1475-2875-11-97 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 29 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20724175&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20724175&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 30 http://dx.doi.org/10.1016/j.jphotobiol.2010.07.010 http://dx.doi.org/10.1016/j.jphotobiol.2010.07.010 FW work_zbi2knhp65ho5n7vbsuthmd7gi 561 31 http://dx.doi.org/10.1016/j.jphotobiol.2010.07.010 http://dx.doi.org/10.1016/j.jphotobiol.2010.07.010 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 32 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20946361&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20946361&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 33 http://dx.doi.org/10.1111/j.1751-1097.2010.00818.x http://dx.doi.org/10.1111/j.1751-1097.2010.00818.x NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 34 http://dx.doi.org/10.1111/j.1751-1097.2010.00818.x http://dx.doi.org/10.1111/j.1751-1097.2010.00818.x NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 35 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16973206&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16973206&dopt=abstract VB work_zbi2knhp65ho5n7vbsuthmd7gi 561 36 http://dx.doi.org/10.1016/j.mam.2006.08.005 http://dx.doi.org/10.1016/j.mam.2006.08.005 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 37 http://dx.doi.org/10.1016/j.mam.2006.08.005 http://dx.doi.org/10.1016/j.mam.2006.08.005 FW work_zbi2knhp65ho5n7vbsuthmd7gi 561 38 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17611390&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=17611390&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 39 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17611390&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=17611390&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 40 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18776737&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18776737&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 41 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21189453&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=21189453&dopt=abstract NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 42 http://dx.doi.org/10.4161/auto.7.3.14487 http://dx.doi.org/10.4161/auto.7.3.14487 NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 43 http://dx.doi.org/10.4161/auto.7.3.14487 http://dx.doi.org/10.4161/auto.7.3.14487 NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 44 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17580304&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17580304&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 45 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17580304&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17580304&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 46 http://dx.doi.org/10.1074/jbc.M702824200 http://dx.doi.org/10.1074/jbc.M702824200 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 47 http://dx.doi.org/10.1074/jbc.M702824200 http://dx.doi.org/10.1074/jbc.M702824200 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 48 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18550537&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18550537&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 49 http://dx.doi.org/10.1074/jbc.M801918200 http://dx.doi.org/10.1074/jbc.m801918200 NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 50 http://dx.doi.org/10.1074/jbc.M801918200 http://dx.doi.org/10.1074/jbc.M801918200 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 51 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18702517&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18702517&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 52 http://dx.doi.org/10.1021/bi800699v http://dx.doi.org/10.1021/bi800699v NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 53 http://dx.doi.org/10.1021/bi800699v http://dx.doi.org/10.1021/bi800699v NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 54 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18769161&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=18769161&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 55 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18769161&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=18769161&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 56 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3342086&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=3342086&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 57 http://dx.doi.org/10.1016/0006-2952(88)90733-2 http://dx.doi.org/10.1016/0006-2952(88)90733-2 PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 561 58 http://dx.doi.org/10.1016/0006-2952(88)90733-2 http://dx.doi.org/10.1016/0006-2952(88)90733-2 NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 59 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19059302&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19059302&dopt=Abstract . work_zbi2knhp65ho5n7vbsuthmd7gi 561 60 http://dx.doi.org/10.1016/j.tox.2008.11.006 http://dx.doi.org/10.1016/j.tox.2008.11.006 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 61 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20144757&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=20144757&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 62 http://dx.doi.org/10.1016/j.cell.2010.01.028 http://dx.doi.org/10.1016/j.cell.2010.01.028 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 63 http://dx.doi.org/10.1016/j.cell.2010.01.028 http://dx.doi.org/10.1016/j.cell.2010.01.028 IN work_zbi2knhp65ho5n7vbsuthmd7gi 561 64 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9639028&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9639028&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 65 http://dx.doi.org/10.1247/csf.23.33 http://dx.doi.org/10.1247/csf.23.33 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 66 http://dx.doi.org/10.1247/csf.23.33 http://dx.doi.org/10.1247/csf.23.33 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 67 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22198553&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22198553&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 68 http://dx.doi.org/10.1016/j.taap.2011.12.004 http://dx.doi.org/10.1016/j.taap.2011.12.004 NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 69 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4550396&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4550396&dopt=Abstract . work_zbi2knhp65ho5n7vbsuthmd7gi 561 70 http://dx.doi.org/10.1038/235050a0 http://dx.doi.org/10.1038/235050a0 FW work_zbi2knhp65ho5n7vbsuthmd7gi 561 71 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8361993&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=8361993&dopt=abstract NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 72 http://dx.doi.org/10.1016/0163-7258(93)90056-J http://dx.doi.org/10.1016/0163-7258(93)90056-j FW work_zbi2knhp65ho5n7vbsuthmd7gi 561 73 http://dx.doi.org/10.1016/0163-7258(93)90056-J http://dx.doi.org/10.1016/0163-7258(93)90056-j PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 561 74 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16314482&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=16314482&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 75 http://dx.doi.org/10.1016/S0002-9440(10)61253-9 http://dx.doi.org/10.1016/s0002-9440(10)61253-9 NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 76 http://dx.doi.org/10.1016/S0002-9440(10)61253-9 http://dx.doi.org/10.1016/s0002-9440(10)61253-9 NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 77 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19858192&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19858192&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 78 http://dx.doi.org/10.1074/jbc.M109.065813 http://dx.doi.org/10.1074/jbc.M109.065813 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 79 http://dx.doi.org/10.1074/jbc.M109.065813 http://dx.doi.org/10.1074/jbc.M109.065813 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 80 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12813466&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12813466&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 81 http://dx.doi.org/10.1038/sj.onc.1206622 http://dx.doi.org/10.1038/sj.onc.1206622 NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 82 http://dx.doi.org/10.1038/sj.onc.1206622 http://dx.doi.org/10.1038/sj.onc.1206622 NFP work_zbi2knhp65ho5n7vbsuthmd7gi 561 83 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12150823&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12150823&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 84 http://dx.doi.org/10.1016/S1535-6108(02)00082-X http://dx.doi.org/10.1016/S1535-6108(02)00082-X NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 85 http://dx.doi.org/10.1016/S1535-6108(02)00082-X http://dx.doi.org/10.1016/S1535-6108(02)00082-X NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 86 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16892091&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16892091&dopt=Abstract . work_zbi2knhp65ho5n7vbsuthmd7gi 561 87 http://dx.doi.org/10.1038/sj.onc.1209599 http://dx.doi.org/10.1038/sj.onc.1209599 UH work_zbi2knhp65ho5n7vbsuthmd7gi 561 88 http://dx.doi.org/10.1038/sj.onc.1209599 http://dx.doi.org/10.1038/sj.onc.1209599 UH work_zbi2knhp65ho5n7vbsuthmd7gi 561 89 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21034357&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21034357&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 90 http://dx.doi.org/10.3109/10715762.2010.526766 http://dx.doi.org/10.3109/10715762.2010.526766 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 561 91 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15899785&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=15899785&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 92 http://dx.doi.org/10.1158/0008-5472.CAN-04-3995 http://dx.doi.org/10.1158/0008-5472.CAN-04-3995 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 561 93 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23429201&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23429201&dopt=abstract RB work_zbi2knhp65ho5n7vbsuthmd7gi 561 94 http://dx.doi.org/10.3390/ijms14024185 http://dx.doi.org/10.3390/ijms14024185 VB work_zbi2knhp65ho5n7vbsuthmd7gi 561 95 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22321511&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22321511&dopt=Abstract . work_zbi2knhp65ho5n7vbsuthmd7gi 561 96 http://dx.doi.org/10.1016/j.bcp.2012.01.027 http://dx.doi.org/10.1016/j.bcp.2012.01.027 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 97 http://dx.doi.org/10.1016/j.bcp.2012.01.027 http://dx.doi.org/10.1016/j.bcp.2012.01.027 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 98 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19269363&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19269363&dopt=abstract FW work_zbi2knhp65ho5n7vbsuthmd7gi 561 99 http://dx.doi.org/10.1016/j.cell.2009.02.024 http://dx.doi.org/10.1016/j.cell.2009.02.024 VB work_zbi2knhp65ho5n7vbsuthmd7gi 561 100 http://dx.doi.org/10.1016/j.cell.2009.02.024 http://dx.doi.org/10.1016/j.cell.2009.02.024 JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 101 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22843330&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22843330&dopt=abstract PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 561 102 http://dx.doi.org/10.1007/s10495-012-0746-x http://dx.doi.org/10.1007/s10495-012-0746-x NNS work_zbi2knhp65ho5n7vbsuthmd7gi 561 103 http://dx.doi.org/10.1007/s10495-012-0746-x http://dx.doi.org/10.1007/s10495-012-0746-x JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 104 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19186174&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19186174&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 105 http://dx.doi.org/10.1016/j.bcp.2008.12.002 http://dx.doi.org/10.1016/j.bcp.2008.12.002 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 106 http://dx.doi.org/10.1016/j.bcp.2008.12.002 http://dx.doi.org/10.1016/j.bcp.2008.12.002 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 107 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23159848&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=23159848&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 108 http://dx.doi.org/10.1097/CCO.0b013e32835b639e http://dx.doi.org/10.1097/CCO.0b013e32835b639e NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 109 http://dx.doi.org/10.1097/CCO.0b013e32835b639e http://dx.doi.org/10.1097/CCO.0b013e32835b639e NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 110 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18676853&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18676853&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 111 http://dx.doi.org/10.1158/0008-5472.CAN-08-0121 http://dx.doi.org/10.1158/0008-5472.CAN-08-0121 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 561 112 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17100600&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=17100600&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 113 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22180494&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22180494&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 114 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22180494&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22180494&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 115 http://dx.doi.org/10.1158/0008-5472.CAN-11-2196 http://dx.doi.org/10.1158/0008-5472.can-11-2196 POS work_zbi2knhp65ho5n7vbsuthmd7gi 561 116 http://dx.doi.org/10.1158/0008-5472.CAN-11-2196 http://dx.doi.org/10.1158/0008-5472.can-11-2196 CD work_zbi2knhp65ho5n7vbsuthmd7gi 561 117 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19922488&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=19922488&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 561 118 http://dx.doi.org/10.1111/j.1365-2184.2009.00657.x http://dx.doi.org/10.1111/j.1365-2184.2009.00657.x NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 119 http://dx.doi.org/10.1111/j.1365-2184.2009.00657.x http://dx.doi.org/10.1111/j.1365-2184.2009.00657.x NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 120 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23634251&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=23634251&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 121 http://dx.doi.org/10.1177/1947601912473305 http://dx.doi.org/10.1177/1947601912473305 VBD work_zbi2knhp65ho5n7vbsuthmd7gi 561 122 http://dx.doi.org/10.1177/1947601912473305 http://dx.doi.org/10.1177/1947601912473305 POS work_zbi2knhp65ho5n7vbsuthmd7gi 561 123 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4607946&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=4607946&dopt=abstract NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 124 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=4607946&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=4607946&dopt=abstract NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 125 http://dx.doi.org/10.1083/jcb.63.2.430 http://dx.doi.org/10.1083/jcb.63.2.430 VB work_zbi2knhp65ho5n7vbsuthmd7gi 561 126 http://dx.doi.org/10.1083/jcb.63.2.430 http://dx.doi.org/10.1083/jcb.63.2.430 VB work_zbi2knhp65ho5n7vbsuthmd7gi 561 127 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22966490&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22966490&dopt=abstract PRP work_zbi2knhp65ho5n7vbsuthmd7gi 561 128 http://dx.doi.org/10.4161/auto.19496 http://dx.doi.org/10.4161/auto.19496 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 561 129 http://dx.doi.org/10.4161/auto.19496 http://dx.doi.org/10.4161/auto.19496 ADD work_zbi2knhp65ho5n7vbsuthmd7gi 561 130 © © NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 131 20 20 CD work_zbi2knhp65ho5n7vbsuthmd7gi 561 132 13 13 CD work_zbi2knhp65ho5n7vbsuthmd7gi 561 133 L l NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 134 an an DT work_zbi2knhp65ho5n7vbsuthmd7gi 561 135 de de NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 136 s s NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 137 B b NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 138 io io RB work_zbi2knhp65ho5n7vbsuthmd7gi 561 139 sc sc RB work_zbi2knhp65ho5n7vbsuthmd7gi 561 140 ie ie NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 141 nc nc FW work_zbi2knhp65ho5n7vbsuthmd7gi 561 142 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 143 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 144 o o NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 145 no no DT work_zbi2knhp65ho5n7vbsuthmd7gi 561 146 t t NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 147 d d NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 148 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 561 149 tr tr IN work_zbi2knhp65ho5n7vbsuthmd7gi 561 150 ib ib IN work_zbi2knhp65ho5n7vbsuthmd7gi 561 151 ut ut UH work_zbi2knhp65ho5n7vbsuthmd7gi 561 152 e. e. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 153 2102 2102 CD work_zbi2knhp65ho5n7vbsuthmd7gi 561 154 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 155 Volume Volume NNP work_zbi2knhp65ho5n7vbsuthmd7gi 561 156 9 9 CD work_zbi2knhp65ho5n7vbsuthmd7gi 561 157 issue issue NN work_zbi2knhp65ho5n7vbsuthmd7gi 561 158 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 561 159 74 74 CD work_zbi2knhp65ho5n7vbsuthmd7gi 561 160 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 562 1 Maclean Maclean NNP work_zbi2knhp65ho5n7vbsuthmd7gi 562 2 KH KH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 562 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 562 4 Dorsey Dorsey NNP work_zbi2knhp65ho5n7vbsuthmd7gi 562 5 FC FC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 562 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 562 7 Cleveland Cleveland NNP work_zbi2knhp65ho5n7vbsuthmd7gi 562 8 JL JL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 562 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 562 10 Kastan Kastan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 562 11 MB MB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 562 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 563 1 Targeting target VBG work_zbi2knhp65ho5n7vbsuthmd7gi 563 2 lysosomal lysosomal JJ work_zbi2knhp65ho5n7vbsuthmd7gi 563 3 degradation degradation NN work_zbi2knhp65ho5n7vbsuthmd7gi 563 4 induces induce VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 563 5 p53-depen- p53-depen- NN work_zbi2knhp65ho5n7vbsuthmd7gi 563 6 dent dent NN work_zbi2knhp65ho5n7vbsuthmd7gi 563 7 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 563 8 death death NN work_zbi2knhp65ho5n7vbsuthmd7gi 563 9 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 563 10 prevents prevent VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 563 11 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 563 12 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 563 13 mouse mouse NN work_zbi2knhp65ho5n7vbsuthmd7gi 563 14 models model NNS work_zbi2knhp65ho5n7vbsuthmd7gi 563 15 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 563 16 lymphomagenesis lymphomagenesis NN work_zbi2knhp65ho5n7vbsuthmd7gi 563 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 564 1 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 564 2 Clin Clin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 564 3 Invest Invest NNP work_zbi2knhp65ho5n7vbsuthmd7gi 564 4 2008 2008 CD work_zbi2knhp65ho5n7vbsuthmd7gi 564 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 564 6 118:79- 118:79- ADD work_zbi2knhp65ho5n7vbsuthmd7gi 564 7 88 88 CD work_zbi2knhp65ho5n7vbsuthmd7gi 564 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 564 9 PMID:18097482 pmid:18097482 NN work_zbi2knhp65ho5n7vbsuthmd7gi 564 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 564 11 http://dx.doi.org/10.1172/ http://dx.doi.org/10.1172/ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 564 12 JCI33700 JCI33700 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 564 13 75 75 CD work_zbi2knhp65ho5n7vbsuthmd7gi 564 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 565 1 Zhu Zhu NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 2 H H NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 565 4 Zhang Zhang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 5 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 565 7 Wu Wu NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 8 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 565 10 Teraishi Teraishi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 11 F F NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 565 13 Davis Davis NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 14 JJ JJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 565 16 Jacob Jacob NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 17 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 565 19 Fang Fang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 565 20 B. B. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 566 1 Induction Induction NNP work_zbi2knhp65ho5n7vbsuthmd7gi 566 2 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 566 3 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 566 4 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 566 5 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 566 6 arrest arrest NN work_zbi2knhp65ho5n7vbsuthmd7gi 566 7 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 566 8 p21 p21 NN work_zbi2knhp65ho5n7vbsuthmd7gi 566 9 overexpression overexpression NN work_zbi2knhp65ho5n7vbsuthmd7gi 566 10 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 566 11 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 566 12 small small JJ work_zbi2knhp65ho5n7vbsuthmd7gi 566 13 molecule molecule NN work_zbi2knhp65ho5n7vbsuthmd7gi 566 14 2[[3-(2,3-dichlo- 2[[3-(2,3-dichlo- CD work_zbi2knhp65ho5n7vbsuthmd7gi 566 15 rophenoxy)propyl rophenoxy)propyl NNP work_zbi2knhp65ho5n7vbsuthmd7gi 566 16 ] ] -RRB- work_zbi2knhp65ho5n7vbsuthmd7gi 566 17 amino]ethanol amino]ethanol NN work_zbi2knhp65ho5n7vbsuthmd7gi 566 18 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 566 19 correlation correlation NN work_zbi2knhp65ho5n7vbsuthmd7gi 566 20 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 566 21 activation activation NN work_zbi2knhp65ho5n7vbsuthmd7gi 566 22 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 566 23 ERK ERK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 566 24 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 567 1 Oncogene oncogene NN work_zbi2knhp65ho5n7vbsuthmd7gi 567 2 2004 2004 CD work_zbi2knhp65ho5n7vbsuthmd7gi 567 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 567 4 23:4984- 23:4984- CD work_zbi2knhp65ho5n7vbsuthmd7gi 567 5 92 92 CD work_zbi2knhp65ho5n7vbsuthmd7gi 567 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 567 7 PMID:15122344 PMID:15122344 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 567 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 567 9 http://dx.doi.org/10.1038/ http://dx.doi.org/10.1038/ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 567 10 sj.onc.1207645 sj.onc.1207645 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 567 11 76 76 CD work_zbi2knhp65ho5n7vbsuthmd7gi 567 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 568 1 Ogryzko Ogryzko NNP work_zbi2knhp65ho5n7vbsuthmd7gi 568 2 V V NNP work_zbi2knhp65ho5n7vbsuthmd7gi 568 3 V V NNP work_zbi2knhp65ho5n7vbsuthmd7gi 568 4 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 568 5 Wong Wong NNP work_zbi2knhp65ho5n7vbsuthmd7gi 568 6 P P NNP work_zbi2knhp65ho5n7vbsuthmd7gi 568 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 568 8 Howard Howard NNP work_zbi2knhp65ho5n7vbsuthmd7gi 568 9 BH BH NNP work_zbi2knhp65ho5n7vbsuthmd7gi 568 10 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 569 1 WAF1 WAF1 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 569 2 retards retard VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 569 3 S s NN work_zbi2knhp65ho5n7vbsuthmd7gi 569 4 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 569 5 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 569 6 progression progression NN work_zbi2knhp65ho5n7vbsuthmd7gi 569 7 primarily primarily RB work_zbi2knhp65ho5n7vbsuthmd7gi 569 8 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 569 9 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 569 10 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 569 11 cyclin- cyclin- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 569 12 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 569 13 kinases kinase NNS work_zbi2knhp65ho5n7vbsuthmd7gi 569 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 570 1 Mol Mol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 570 2 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 570 3 Biol Biol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 570 4 1997 1997 CD work_zbi2knhp65ho5n7vbsuthmd7gi 570 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 570 6 17:4877 17:4877 CD work_zbi2knhp65ho5n7vbsuthmd7gi 570 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 570 8 82 82 CD work_zbi2knhp65ho5n7vbsuthmd7gi 570 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 570 10 PMID:9234744 PMID:9234744 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 570 11 77 77 CD work_zbi2knhp65ho5n7vbsuthmd7gi 570 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 571 1 Joe Joe NNP work_zbi2knhp65ho5n7vbsuthmd7gi 571 2 AK AK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 571 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 571 4 Liu Liu NNP work_zbi2knhp65ho5n7vbsuthmd7gi 571 5 H H NNP work_zbi2knhp65ho5n7vbsuthmd7gi 571 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 571 7 Suzui Suzui NNP work_zbi2knhp65ho5n7vbsuthmd7gi 571 8 M M NNP work_zbi2knhp65ho5n7vbsuthmd7gi 571 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 571 10 Vural Vural NNP work_zbi2knhp65ho5n7vbsuthmd7gi 571 11 ME ME NNP work_zbi2knhp65ho5n7vbsuthmd7gi 571 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 571 13 Xiao Xiao NNP work_zbi2knhp65ho5n7vbsuthmd7gi 571 14 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 571 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 571 16 Weinstein Weinstein NNP work_zbi2knhp65ho5n7vbsuthmd7gi 571 17 IB IB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 571 18 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 572 1 Resveratrol Resveratrol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 572 2 induces induce VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 572 3 growth growth NN work_zbi2knhp65ho5n7vbsuthmd7gi 572 4 inhibition inhibition NN work_zbi2knhp65ho5n7vbsuthmd7gi 572 5 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 572 6 S s NN work_zbi2knhp65ho5n7vbsuthmd7gi 572 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 572 8 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 572 9 arrest arrest NN work_zbi2knhp65ho5n7vbsuthmd7gi 572 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 572 11 apoptosis apoptosis NN work_zbi2knhp65ho5n7vbsuthmd7gi 572 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 572 13 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 572 14 changes change NNS work_zbi2knhp65ho5n7vbsuthmd7gi 572 15 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 572 16 biomarker biomarker NN work_zbi2knhp65ho5n7vbsuthmd7gi 572 17 expression expression NN work_zbi2knhp65ho5n7vbsuthmd7gi 572 18 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 572 19 several several JJ work_zbi2knhp65ho5n7vbsuthmd7gi 572 20 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 572 21 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 572 22 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 572 23 lines line NNS work_zbi2knhp65ho5n7vbsuthmd7gi 572 24 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 573 1 Clin Clin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 573 2 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 573 3 Res Res NNP work_zbi2knhp65ho5n7vbsuthmd7gi 573 4 2002 2002 CD work_zbi2knhp65ho5n7vbsuthmd7gi 573 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 573 6 8:893 8:893 CD work_zbi2knhp65ho5n7vbsuthmd7gi 573 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 573 8 903 903 CD work_zbi2knhp65ho5n7vbsuthmd7gi 573 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 573 10 PMID:11895924 PMID:11895924 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 573 11 78 78 CD work_zbi2knhp65ho5n7vbsuthmd7gi 573 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 574 1 Knudsen Knudsen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 2 KE KE NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 574 4 Booth Booth NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 5 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 574 7 Naderi Naderi NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 8 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 574 10 Sever Sever NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 11 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 574 12 Chroneos Chroneos NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 13 Z Z NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 14 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 574 15 Fribourg Fribourg NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 16 AF AF NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 17 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 574 18 Hunton Hunton NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 19 IC IC NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 20 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 574 21 Feramisco Feramisco NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 22 JR JR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 23 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 574 24 Wang Wang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 25 JY JY NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 26 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 574 27 Knudsen Knudsen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 28 ES ES NNP work_zbi2knhp65ho5n7vbsuthmd7gi 574 29 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 575 1 RB RB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 575 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 575 3 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 575 4 S s JJ work_zbi2knhp65ho5n7vbsuthmd7gi 575 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 575 6 phase phase NN work_zbi2knhp65ho5n7vbsuthmd7gi 575 7 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 575 8 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 575 9 DNA dna NN work_zbi2knhp65ho5n7vbsuthmd7gi 575 10 damage damage NN work_zbi2knhp65ho5n7vbsuthmd7gi 575 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 576 1 Mol Mol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 576 2 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 576 3 Biol Biol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 576 4 2000 2000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 576 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 576 6 20:7751- 20:7751- CD work_zbi2knhp65ho5n7vbsuthmd7gi 576 7 63 63 CD work_zbi2knhp65ho5n7vbsuthmd7gi 576 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 576 9 PMID:11003670 PMID:11003670 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 576 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 576 11 http://dx.doi.org/10.1128/ http://dx.doi.org/10.1128/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 576 12 MCB.20.20.7751 MCB.20.20.7751 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 576 13 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 576 14 7763.2000 7763.2000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 576 15 79 79 CD work_zbi2knhp65ho5n7vbsuthmd7gi 576 16 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 577 1 Hockenbery Hockenbery NNP work_zbi2knhp65ho5n7vbsuthmd7gi 577 2 DM DM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 577 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 578 1 Targeting target VBG work_zbi2knhp65ho5n7vbsuthmd7gi 578 2 mitochondria mitochondrion NNS work_zbi2knhp65ho5n7vbsuthmd7gi 578 3 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 578 4 can- can- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 578 5 cer cer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 578 6 therapy therapy NN work_zbi2knhp65ho5n7vbsuthmd7gi 578 7 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 579 1 Environ Environ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 579 2 Mol Mol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 579 3 Mutagen Mutagen NNP work_zbi2knhp65ho5n7vbsuthmd7gi 579 4 2010 2010 CD work_zbi2knhp65ho5n7vbsuthmd7gi 579 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 579 6 51:476- 51:476- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 579 7 89 89 CD work_zbi2knhp65ho5n7vbsuthmd7gi 579 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 579 9 PMID:20213841 PMID:20213841 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 579 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 579 11 http://dx.doi.org/10.1002/ http://dx.doi.org/10.1002/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 579 12 em.20552 em.20552 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 579 13 80 80 CD work_zbi2knhp65ho5n7vbsuthmd7gi 579 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 580 1 Maycotte Maycotte NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 2 P P NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 580 4 Aryal Aryal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 5 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 580 7 Cummings cumming NNS work_zbi2knhp65ho5n7vbsuthmd7gi 580 8 CT CT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 580 10 Thorburn Thorburn NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 11 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 580 13 Morgan Morgan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 14 MJ MJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 15 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 580 16 Thorburn Thorburn NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 17 A. a. NN work_zbi2knhp65ho5n7vbsuthmd7gi 580 18 Chloroquine Chloroquine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 19 sensi- sensi- NN work_zbi2knhp65ho5n7vbsuthmd7gi 580 20 tizes tize VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 580 21 breast breast NN work_zbi2knhp65ho5n7vbsuthmd7gi 580 22 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 580 23 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 580 24 to to TO work_zbi2knhp65ho5n7vbsuthmd7gi 580 25 chemotherapy chemotherapy VB work_zbi2knhp65ho5n7vbsuthmd7gi 580 26 indepen- indepen- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 27 dent dent NN work_zbi2knhp65ho5n7vbsuthmd7gi 580 28 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 580 29 autophagy autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 580 30 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 581 1 Autophagy Autophagy NNP work_zbi2knhp65ho5n7vbsuthmd7gi 581 2 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 581 3 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 581 4 8:200 8:200 CD work_zbi2knhp65ho5n7vbsuthmd7gi 581 5 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 581 6 12 12 CD work_zbi2knhp65ho5n7vbsuthmd7gi 581 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 581 8 PMID:22252008 pmid:22252008 NN work_zbi2knhp65ho5n7vbsuthmd7gi 581 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 581 10 http://dx.doi.org/10.4161/ http://dx.doi.org/10.4161/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 581 11 auto.8.2.18554 auto.8.2.18554 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 581 12 81 81 CD work_zbi2knhp65ho5n7vbsuthmd7gi 581 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 582 1 Neckers Neckers NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 582 2 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 582 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 582 4 Workman Workman NNP work_zbi2knhp65ho5n7vbsuthmd7gi 582 5 P. P. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 582 6 Hsp90 Hsp90 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 582 7 molecular molecular NN work_zbi2knhp65ho5n7vbsuthmd7gi 582 8 chap- chap- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 582 9 erone erone NN work_zbi2knhp65ho5n7vbsuthmd7gi 582 10 inhibitors inhibitor NNS work_zbi2knhp65ho5n7vbsuthmd7gi 582 11 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 582 12 are be VBP work_zbi2knhp65ho5n7vbsuthmd7gi 582 13 we -PRON- PRP work_zbi2knhp65ho5n7vbsuthmd7gi 582 14 there there EX work_zbi2knhp65ho5n7vbsuthmd7gi 582 15 yet yet RB work_zbi2knhp65ho5n7vbsuthmd7gi 582 16 ? ? . work_zbi2knhp65ho5n7vbsuthmd7gi 583 1 Clin Clin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 583 2 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 583 3 Res Res NNP work_zbi2knhp65ho5n7vbsuthmd7gi 583 4 2012 2012 CD work_zbi2knhp65ho5n7vbsuthmd7gi 583 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 583 6 18:64 18:64 CD work_zbi2knhp65ho5n7vbsuthmd7gi 583 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 583 8 76 76 CD work_zbi2knhp65ho5n7vbsuthmd7gi 583 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 583 10 PMID:22215907 PMID:22215907 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 583 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 583 12 http://dx.doi http://dx.doi NN work_zbi2knhp65ho5n7vbsuthmd7gi 583 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 584 1 org/10.1158/1078 org/10.1158/1078 CD work_zbi2knhp65ho5n7vbsuthmd7gi 584 2 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 584 3 0432.CCR-11 0432.ccr-11 CD work_zbi2knhp65ho5n7vbsuthmd7gi 584 4 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 584 5 1000 1000 CD work_zbi2knhp65ho5n7vbsuthmd7gi 584 6 82 82 CD work_zbi2knhp65ho5n7vbsuthmd7gi 584 7 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 585 1 Wang Wang NNP work_zbi2knhp65ho5n7vbsuthmd7gi 585 2 RE RE NNP work_zbi2knhp65ho5n7vbsuthmd7gi 585 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 586 1 Targeting target VBG work_zbi2knhp65ho5n7vbsuthmd7gi 586 2 heat heat NN work_zbi2knhp65ho5n7vbsuthmd7gi 586 3 shock shock NN work_zbi2knhp65ho5n7vbsuthmd7gi 586 4 proteins protein VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 586 5 70/90 70/90 CD work_zbi2knhp65ho5n7vbsuthmd7gi 586 6 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 586 7 proteasome proteasome NN work_zbi2knhp65ho5n7vbsuthmd7gi 586 8 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 586 9 cancer cancer NN work_zbi2knhp65ho5n7vbsuthmd7gi 586 10 therapy therapy NN work_zbi2knhp65ho5n7vbsuthmd7gi 586 11 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 587 1 Curr curr NN work_zbi2knhp65ho5n7vbsuthmd7gi 587 2 Med Med NNP work_zbi2knhp65ho5n7vbsuthmd7gi 587 3 Chem Chem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 587 4 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 587 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 587 6 18:4250 18:4250 CD work_zbi2knhp65ho5n7vbsuthmd7gi 587 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 587 8 64 64 CD work_zbi2knhp65ho5n7vbsuthmd7gi 587 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 587 10 PMID:21838681 pmid:21838681 NN work_zbi2knhp65ho5n7vbsuthmd7gi 587 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 587 12 http://dx.doi http://dx.doi NN work_zbi2knhp65ho5n7vbsuthmd7gi 587 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 588 1 org/10.2174/092986711797189574 org/10.2174/092986711797189574 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 588 2 83 83 CD work_zbi2knhp65ho5n7vbsuthmd7gi 588 3 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 589 1 Ochong Ochong NNP work_zbi2knhp65ho5n7vbsuthmd7gi 589 2 EO EO NNP work_zbi2knhp65ho5n7vbsuthmd7gi 589 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 589 4 van van NNP work_zbi2knhp65ho5n7vbsuthmd7gi 589 5 den den NNP work_zbi2knhp65ho5n7vbsuthmd7gi 589 6 Broek Broek NNP work_zbi2knhp65ho5n7vbsuthmd7gi 589 7 IV IV NNP work_zbi2knhp65ho5n7vbsuthmd7gi 589 8 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 589 9 Keus Keus NNP work_zbi2knhp65ho5n7vbsuthmd7gi 589 10 K K NNP work_zbi2knhp65ho5n7vbsuthmd7gi 589 11 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 589 12 Nzila Nzila NNP work_zbi2knhp65ho5n7vbsuthmd7gi 589 13 A. A. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 590 1 Short short JJ work_zbi2knhp65ho5n7vbsuthmd7gi 590 2 report report NN work_zbi2knhp65ho5n7vbsuthmd7gi 590 3 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 590 4 association association NN work_zbi2knhp65ho5n7vbsuthmd7gi 590 5 between between IN work_zbi2knhp65ho5n7vbsuthmd7gi 590 6 chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 590 7 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 590 8 amodiaquine amodiaquine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 590 9 resistance resistance NN work_zbi2knhp65ho5n7vbsuthmd7gi 590 10 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 590 11 allelic allelic JJ work_zbi2knhp65ho5n7vbsuthmd7gi 590 12 variation variation NN work_zbi2knhp65ho5n7vbsuthmd7gi 590 13 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 590 14 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 590 15 Plasmodium Plasmodium NNP work_zbi2knhp65ho5n7vbsuthmd7gi 590 16 falciparum falciparum NN work_zbi2knhp65ho5n7vbsuthmd7gi 590 17 multiple multiple JJ work_zbi2knhp65ho5n7vbsuthmd7gi 590 18 drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 590 19 resistance resistance NN work_zbi2knhp65ho5n7vbsuthmd7gi 590 20 1 1 CD work_zbi2knhp65ho5n7vbsuthmd7gi 590 21 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 590 22 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 590 23 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 590 24 chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 590 25 resistance resistance NNP work_zbi2knhp65ho5n7vbsuthmd7gi 590 26 transporter transporter NN work_zbi2knhp65ho5n7vbsuthmd7gi 590 27 gene gene NN work_zbi2knhp65ho5n7vbsuthmd7gi 590 28 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 590 29 isolates isolate NNS work_zbi2knhp65ho5n7vbsuthmd7gi 590 30 from from IN work_zbi2knhp65ho5n7vbsuthmd7gi 590 31 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 590 32 upper upper JJ work_zbi2knhp65ho5n7vbsuthmd7gi 590 33 Nile Nile NNP work_zbi2knhp65ho5n7vbsuthmd7gi 590 34 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 590 35 southern southern JJ work_zbi2knhp65ho5n7vbsuthmd7gi 590 36 Sudan Sudan NNP work_zbi2knhp65ho5n7vbsuthmd7gi 590 37 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 591 1 Am Am NNP work_zbi2knhp65ho5n7vbsuthmd7gi 591 2 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 591 3 Trop Trop NNP work_zbi2knhp65ho5n7vbsuthmd7gi 591 4 Med Med NNP work_zbi2knhp65ho5n7vbsuthmd7gi 591 5 Hyg Hyg NNP work_zbi2knhp65ho5n7vbsuthmd7gi 591 6 2003 2003 CD work_zbi2knhp65ho5n7vbsuthmd7gi 591 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 591 8 69:184 69:184 CD work_zbi2knhp65ho5n7vbsuthmd7gi 591 9 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 591 10 7 7 CD work_zbi2knhp65ho5n7vbsuthmd7gi 591 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 591 12 PMID:13677373 PMID:13677373 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 591 13 84 84 CD work_zbi2knhp65ho5n7vbsuthmd7gi 591 14 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 592 1 Famin Famin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 592 2 O O NNP work_zbi2knhp65ho5n7vbsuthmd7gi 592 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 592 4 Ginsburg Ginsburg NNP work_zbi2knhp65ho5n7vbsuthmd7gi 592 5 H. H. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 592 6 Differential Differential NNP work_zbi2knhp65ho5n7vbsuthmd7gi 592 7 effects effect NNS work_zbi2knhp65ho5n7vbsuthmd7gi 592 8 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 592 9 4-ami- 4-ami- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 592 10 noquinoline noquinoline RB work_zbi2knhp65ho5n7vbsuthmd7gi 592 11 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 592 12 containing contain VBG work_zbi2knhp65ho5n7vbsuthmd7gi 592 13 antimalarial antimalarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 592 14 drugs drug NNS work_zbi2knhp65ho5n7vbsuthmd7gi 592 15 on on IN work_zbi2knhp65ho5n7vbsuthmd7gi 592 16 hemo- hemo- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 592 17 globin globin NN work_zbi2knhp65ho5n7vbsuthmd7gi 592 18 digestion digestion NN work_zbi2knhp65ho5n7vbsuthmd7gi 592 19 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 592 20 Plasmodium Plasmodium NNP work_zbi2knhp65ho5n7vbsuthmd7gi 592 21 falciparum falciparum NN work_zbi2knhp65ho5n7vbsuthmd7gi 592 22 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 592 23 infected infect VBN work_zbi2knhp65ho5n7vbsuthmd7gi 592 24 erythrocytes erythrocyte NNS work_zbi2knhp65ho5n7vbsuthmd7gi 592 25 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 593 1 Biochem Biochem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 593 2 Pharmacol Pharmacol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 593 3 2002 2002 CD work_zbi2knhp65ho5n7vbsuthmd7gi 593 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 593 5 63:393- 63:393- NNS work_zbi2knhp65ho5n7vbsuthmd7gi 593 6 8 8 CD work_zbi2knhp65ho5n7vbsuthmd7gi 593 7 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 593 8 PMID:11853690 PMID:11853690 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 593 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 593 10 http://dx.doi.org/10.1016/ http://dx.doi.org/10.1016/ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 593 11 S0006 S0006 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 593 12 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 593 13 2952(01)00878 2952(01)00878 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 593 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 593 15 4 4 CD work_zbi2knhp65ho5n7vbsuthmd7gi 593 16 85 85 CD work_zbi2knhp65ho5n7vbsuthmd7gi 593 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 594 1 Obua Obua NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 2 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 594 4 Gustafsson Gustafsson NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 5 LL LL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 594 7 Aguttu Aguttu NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 8 C C NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 594 10 Anokbonggo Anokbonggo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 11 W W NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 12 W W NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 594 14 Ogwal Ogwal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 15 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 594 16 Okeng Okeng NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 17 JW JW NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 18 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 594 19 Chiria Chiria NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 20 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 21 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 594 22 Hellgren Hellgren NNP work_zbi2knhp65ho5n7vbsuthmd7gi 594 23 U. U. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 595 1 Improved improved JJ work_zbi2knhp65ho5n7vbsuthmd7gi 595 2 efficacy efficacy NN work_zbi2knhp65ho5n7vbsuthmd7gi 595 3 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 595 4 amodiaquine amodiaquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 595 5 instead instead RB work_zbi2knhp65ho5n7vbsuthmd7gi 595 6 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 595 7 chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 595 8 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 595 9 sulfadoxine sulfadoxine NNP work_zbi2knhp65ho5n7vbsuthmd7gi 595 10 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 595 11 pyrimethamine pyrimethamine JJ work_zbi2knhp65ho5n7vbsuthmd7gi 595 12 combi- combi- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 595 13 nation nation NN work_zbi2knhp65ho5n7vbsuthmd7gi 595 14 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 595 15 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 595 16 falciparum falciparum NN work_zbi2knhp65ho5n7vbsuthmd7gi 595 17 malaria malaria NN work_zbi2knhp65ho5n7vbsuthmd7gi 595 18 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 595 19 Uganda Uganda NNP work_zbi2knhp65ho5n7vbsuthmd7gi 595 20 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 595 21 experience experience NN work_zbi2knhp65ho5n7vbsuthmd7gi 595 22 with with IN work_zbi2knhp65ho5n7vbsuthmd7gi 595 23 fixed fix VBN work_zbi2knhp65ho5n7vbsuthmd7gi 595 24 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 595 25 dose dose NN work_zbi2knhp65ho5n7vbsuthmd7gi 595 26 formulation formulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 595 27 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 596 1 Acta Acta NNP work_zbi2knhp65ho5n7vbsuthmd7gi 596 2 Trop Trop NNP work_zbi2knhp65ho5n7vbsuthmd7gi 596 3 2006 2006 CD work_zbi2knhp65ho5n7vbsuthmd7gi 596 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 596 5 100:142 100:142 CD work_zbi2knhp65ho5n7vbsuthmd7gi 596 6 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 596 7 50 50 CD work_zbi2knhp65ho5n7vbsuthmd7gi 596 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 596 9 PMID:17113554 PMID:17113554 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 596 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 596 11 http://dx.doi http://dx.doi UH work_zbi2knhp65ho5n7vbsuthmd7gi 596 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 597 1 org/10.1016 org/10.1016 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 597 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 597 3 j.actatropica.2006.10.007 j.actatropica.2006.10.007 CD work_zbi2knhp65ho5n7vbsuthmd7gi 597 4 86 86 CD work_zbi2knhp65ho5n7vbsuthmd7gi 597 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 598 1 Hawley Hawley NNP work_zbi2knhp65ho5n7vbsuthmd7gi 598 2 SR SR NNP work_zbi2knhp65ho5n7vbsuthmd7gi 598 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 598 4 Bray Bray NNP work_zbi2knhp65ho5n7vbsuthmd7gi 598 5 PG PG NNP work_zbi2knhp65ho5n7vbsuthmd7gi 598 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 598 7 Park Park NNP work_zbi2knhp65ho5n7vbsuthmd7gi 598 8 BK BK NNP work_zbi2knhp65ho5n7vbsuthmd7gi 598 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 598 10 Ward Ward NNP work_zbi2knhp65ho5n7vbsuthmd7gi 598 11 SA SA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 598 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 599 1 Amodiaquine amodiaquine JJ work_zbi2knhp65ho5n7vbsuthmd7gi 599 2 accumulation accumulation NN work_zbi2knhp65ho5n7vbsuthmd7gi 599 3 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 599 4 Plasmodium Plasmodium NNP work_zbi2knhp65ho5n7vbsuthmd7gi 599 5 falci- falci- NN work_zbi2knhp65ho5n7vbsuthmd7gi 599 6 parum parum NN work_zbi2knhp65ho5n7vbsuthmd7gi 599 7 as as IN work_zbi2knhp65ho5n7vbsuthmd7gi 599 8 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 599 9 possible possible JJ work_zbi2knhp65ho5n7vbsuthmd7gi 599 10 explanation explanation NN work_zbi2knhp65ho5n7vbsuthmd7gi 599 11 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 599 12 its -PRON- PRP$ work_zbi2knhp65ho5n7vbsuthmd7gi 599 13 superior superior JJ work_zbi2knhp65ho5n7vbsuthmd7gi 599 14 anti- anti- NN work_zbi2knhp65ho5n7vbsuthmd7gi 599 15 malarial malarial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 599 16 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 599 17 over over IN work_zbi2knhp65ho5n7vbsuthmd7gi 599 18 chloroquine chloroquine NN work_zbi2knhp65ho5n7vbsuthmd7gi 599 19 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 600 1 Mol Mol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 600 2 Biochem Biochem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 600 3 Parasitol Parasitol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 600 4 1996 1996 CD work_zbi2knhp65ho5n7vbsuthmd7gi 600 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 600 6 80:15 80:15 CD work_zbi2knhp65ho5n7vbsuthmd7gi 600 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 600 8 25 25 CD work_zbi2knhp65ho5n7vbsuthmd7gi 600 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 600 10 PMID:8885219 PMID:8885219 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 600 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 600 12 http:// http:// NNP work_zbi2knhp65ho5n7vbsuthmd7gi 600 13 dx.doi.org/10.1016/0166-6851(96)02655-2 dx.doi.org/10.1016/0166-6851(96)02655-2 VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 600 14 87 87 CD work_zbi2knhp65ho5n7vbsuthmd7gi 600 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 601 1 Mirković Mirković NNP work_zbi2knhp65ho5n7vbsuthmd7gi 601 2 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 601 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 601 4 Sosič Sosič NNP work_zbi2knhp65ho5n7vbsuthmd7gi 601 5 I I NNP work_zbi2knhp65ho5n7vbsuthmd7gi 601 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 601 7 Gobec Gobec NNP work_zbi2knhp65ho5n7vbsuthmd7gi 601 8 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 601 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 601 10 Kos Kos NNP work_zbi2knhp65ho5n7vbsuthmd7gi 601 11 J. J. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 601 12 Redox Redox NNP work_zbi2knhp65ho5n7vbsuthmd7gi 601 13 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 601 14 based base VBN work_zbi2knhp65ho5n7vbsuthmd7gi 601 15 inactivation inactivation NN work_zbi2knhp65ho5n7vbsuthmd7gi 601 16 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 601 17 cysteine cysteine JJ work_zbi2knhp65ho5n7vbsuthmd7gi 601 18 cathepsins cathepsin NNS work_zbi2knhp65ho5n7vbsuthmd7gi 601 19 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 601 20 compounds compound NNS work_zbi2knhp65ho5n7vbsuthmd7gi 601 21 containing contain VBG work_zbi2knhp65ho5n7vbsuthmd7gi 601 22 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 601 23 4-aminophenol 4-aminophenol CD work_zbi2knhp65ho5n7vbsuthmd7gi 601 24 moiety moiety NN work_zbi2knhp65ho5n7vbsuthmd7gi 601 25 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 602 1 PLoS plos ADD work_zbi2knhp65ho5n7vbsuthmd7gi 602 2 One one CD work_zbi2knhp65ho5n7vbsuthmd7gi 602 3 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 602 4 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 602 5 6 6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 602 6 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 602 7 e27197 e27197 NN work_zbi2knhp65ho5n7vbsuthmd7gi 602 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 602 9 PMID:22073285 PMID:22073285 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 602 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 602 11 http://dx.doi http://dx.doi NN work_zbi2knhp65ho5n7vbsuthmd7gi 602 12 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 603 1 org/10.1371 org/10.1371 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 603 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 603 3 journal.pone.0027197 journal.pone.0027197 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 603 4 88 88 CD work_zbi2knhp65ho5n7vbsuthmd7gi 603 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 604 1 Parikh Parikh NNP work_zbi2knhp65ho5n7vbsuthmd7gi 604 2 S S NNP work_zbi2knhp65ho5n7vbsuthmd7gi 604 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 604 4 Ouedraogo Ouedraogo NNP work_zbi2knhp65ho5n7vbsuthmd7gi 604 5 JB JB NNP work_zbi2knhp65ho5n7vbsuthmd7gi 604 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 604 7 Goldstein Goldstein NNP work_zbi2knhp65ho5n7vbsuthmd7gi 604 8 JA JA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 604 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 604 10 Rosenthal Rosenthal NNP work_zbi2knhp65ho5n7vbsuthmd7gi 604 11 PJ PJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 604 12 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 604 13 Kroetz Kroetz NNP work_zbi2knhp65ho5n7vbsuthmd7gi 604 14 DL DL NNP work_zbi2knhp65ho5n7vbsuthmd7gi 604 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 605 1 Amodiaquine amodiaquine JJ work_zbi2knhp65ho5n7vbsuthmd7gi 605 2 metabolism metabolism NN work_zbi2knhp65ho5n7vbsuthmd7gi 605 3 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 605 4 impaired impair VBN work_zbi2knhp65ho5n7vbsuthmd7gi 605 5 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 605 6 common common JJ work_zbi2knhp65ho5n7vbsuthmd7gi 605 7 polymorphisms polymorphism NNS work_zbi2knhp65ho5n7vbsuthmd7gi 605 8 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 605 9 CYP2C8 CYP2C8 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 605 10 : : : work_zbi2knhp65ho5n7vbsuthmd7gi 605 11 implications implication NNS work_zbi2knhp65ho5n7vbsuthmd7gi 605 12 for for IN work_zbi2knhp65ho5n7vbsuthmd7gi 605 13 malaria malaria NN work_zbi2knhp65ho5n7vbsuthmd7gi 605 14 treatment treatment NN work_zbi2knhp65ho5n7vbsuthmd7gi 605 15 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 605 16 Africa Africa NNP work_zbi2knhp65ho5n7vbsuthmd7gi 605 17 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 606 1 Clin Clin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 606 2 Pharmacol Pharmacol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 606 3 Ther Ther NNP work_zbi2knhp65ho5n7vbsuthmd7gi 606 4 2007 2007 CD work_zbi2knhp65ho5n7vbsuthmd7gi 606 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 606 6 82:197 82:197 CD work_zbi2knhp65ho5n7vbsuthmd7gi 606 7 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 606 8 203 203 CD work_zbi2knhp65ho5n7vbsuthmd7gi 606 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 606 10 PMID:17361129 PMID:17361129 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 606 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 606 12 http://dx.doi http://dx.doi UH work_zbi2knhp65ho5n7vbsuthmd7gi 606 13 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 607 1 org/10.1038 org/10.1038 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 607 2 / / SYM work_zbi2knhp65ho5n7vbsuthmd7gi 607 3 sj.clpt.6100122 sj.clpt.6100122 $ work_zbi2knhp65ho5n7vbsuthmd7gi 607 4 89 89 CD work_zbi2knhp65ho5n7vbsuthmd7gi 607 5 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 608 1 Roederer roederer JJ work_zbi2knhp65ho5n7vbsuthmd7gi 608 2 MW MW NNP work_zbi2knhp65ho5n7vbsuthmd7gi 608 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 608 4 McLeod mcleod NN work_zbi2knhp65ho5n7vbsuthmd7gi 608 5 H h NN work_zbi2knhp65ho5n7vbsuthmd7gi 608 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 608 7 Juliano Juliano NNP work_zbi2knhp65ho5n7vbsuthmd7gi 608 8 JJ JJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 608 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 609 1 Can Can MD work_zbi2knhp65ho5n7vbsuthmd7gi 609 2 pharma- pharma- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 609 3 cogenomics cogenomic NNS work_zbi2knhp65ho5n7vbsuthmd7gi 609 4 improve improve VB work_zbi2knhp65ho5n7vbsuthmd7gi 609 5 malaria malaria NN work_zbi2knhp65ho5n7vbsuthmd7gi 609 6 drug drug NN work_zbi2knhp65ho5n7vbsuthmd7gi 609 7 policy policy NN work_zbi2knhp65ho5n7vbsuthmd7gi 609 8 ? ? . work_zbi2knhp65ho5n7vbsuthmd7gi 610 1 Bull Bull NNP work_zbi2knhp65ho5n7vbsuthmd7gi 610 2 World World NNP work_zbi2knhp65ho5n7vbsuthmd7gi 610 3 Health Health NNP work_zbi2knhp65ho5n7vbsuthmd7gi 610 4 Organ Organ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 610 5 2011 2011 CD work_zbi2knhp65ho5n7vbsuthmd7gi 610 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 610 7 89:838 89:838 CD work_zbi2knhp65ho5n7vbsuthmd7gi 610 8 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 610 9 45 45 CD work_zbi2knhp65ho5n7vbsuthmd7gi 610 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 610 11 PMID:22084530 PMID:22084530 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 610 12 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 610 13 http://dx.doi.org/10.2471/BLT.11.087320 http://dx.doi.org/10.2471/BLT.11.087320 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 610 14 90 90 CD work_zbi2knhp65ho5n7vbsuthmd7gi 610 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 611 1 Lamore Lamore NNP work_zbi2knhp65ho5n7vbsuthmd7gi 611 2 SD SD NNP work_zbi2knhp65ho5n7vbsuthmd7gi 611 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 611 4 Cabello Cabello NNP work_zbi2knhp65ho5n7vbsuthmd7gi 611 5 CM CM NNP work_zbi2knhp65ho5n7vbsuthmd7gi 611 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 611 7 Wondrak Wondrak NNP work_zbi2knhp65ho5n7vbsuthmd7gi 611 8 GT GT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 611 9 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 612 1 The the DT work_zbi2knhp65ho5n7vbsuthmd7gi 612 2 topi- topi- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 612 3 cal cal NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 4 antimicrobial antimicrobial JJ work_zbi2knhp65ho5n7vbsuthmd7gi 612 5 zinc zinc NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 6 pyrithione pyrithione NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 7 is be VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 612 8 a a DT work_zbi2knhp65ho5n7vbsuthmd7gi 612 9 heat heat NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 10 shock shock NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 11 response response NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 12 inducer inducer NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 13 that that WDT work_zbi2knhp65ho5n7vbsuthmd7gi 612 14 causes cause VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 612 15 DNA dna NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 16 damage damage NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 17 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 612 18 PARP parp NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 19 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 612 20 dependent dependent JJ work_zbi2knhp65ho5n7vbsuthmd7gi 612 21 energy energy NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 22 crisis crisis NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 23 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 612 24 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 612 25 skin skin NN work_zbi2knhp65ho5n7vbsuthmd7gi 612 26 cells cell NNS work_zbi2knhp65ho5n7vbsuthmd7gi 612 27 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 613 1 Cell Cell NNP work_zbi2knhp65ho5n7vbsuthmd7gi 613 2 Stress Stress NNP work_zbi2knhp65ho5n7vbsuthmd7gi 613 3 Chaperones Chaperones NNPS work_zbi2knhp65ho5n7vbsuthmd7gi 613 4 2010 2010 CD work_zbi2knhp65ho5n7vbsuthmd7gi 613 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 613 6 15:309 15:309 CD work_zbi2knhp65ho5n7vbsuthmd7gi 613 7 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 613 8 22 22 CD work_zbi2knhp65ho5n7vbsuthmd7gi 613 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 613 10 PMID:19809895 pmid:19809895 NN work_zbi2knhp65ho5n7vbsuthmd7gi 613 11 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 613 12 http://dx.doi.org/10.1007/ http://dx.doi.org/10.1007/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 613 13 s12192 s12192 CD work_zbi2knhp65ho5n7vbsuthmd7gi 613 14 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 613 15 009 009 CD work_zbi2knhp65ho5n7vbsuthmd7gi 613 16 - - HYPH work_zbi2knhp65ho5n7vbsuthmd7gi 613 17 0145 0145 CD work_zbi2knhp65ho5n7vbsuthmd7gi 613 18 - - SYM work_zbi2knhp65ho5n7vbsuthmd7gi 613 19 6 6 CD work_zbi2knhp65ho5n7vbsuthmd7gi 613 20 91 91 CD work_zbi2knhp65ho5n7vbsuthmd7gi 613 21 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 614 1 Werle Werle NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 2 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 614 4 Ebert Ebert NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 5 W W NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 6 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 614 7 Klein Klein NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 8 W W NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 9 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 614 10 Spiess Spiess NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 11 E. E. NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 12 Assessment Assessment NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 13 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 614 14 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 15 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 16 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 614 17 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 614 18 use use NN work_zbi2knhp65ho5n7vbsuthmd7gi 614 19 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 614 20 the the DT work_zbi2knhp65ho5n7vbsuthmd7gi 614 21 inhibitor inhibitor NN work_zbi2knhp65ho5n7vbsuthmd7gi 614 22 CA-074 CA-074 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 23 compared compare VBN work_zbi2knhp65ho5n7vbsuthmd7gi 614 24 to to IN work_zbi2knhp65ho5n7vbsuthmd7gi 614 25 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 26 B B NNP work_zbi2knhp65ho5n7vbsuthmd7gi 614 27 activity activity NN work_zbi2knhp65ho5n7vbsuthmd7gi 614 28 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 614 29 human human JJ work_zbi2knhp65ho5n7vbsuthmd7gi 614 30 lung lung NN work_zbi2knhp65ho5n7vbsuthmd7gi 614 31 tumor tumor NN work_zbi2knhp65ho5n7vbsuthmd7gi 614 32 tissue tissue NN work_zbi2knhp65ho5n7vbsuthmd7gi 614 33 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 615 1 Biol Biol NNP work_zbi2knhp65ho5n7vbsuthmd7gi 615 2 Chem Chem NNP work_zbi2knhp65ho5n7vbsuthmd7gi 615 3 Hoppe Hoppe NNP work_zbi2knhp65ho5n7vbsuthmd7gi 615 4 Seyler Seyler NNP work_zbi2knhp65ho5n7vbsuthmd7gi 615 5 1995 1995 CD work_zbi2knhp65ho5n7vbsuthmd7gi 615 6 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 615 7 376:157- 376:157- CD work_zbi2knhp65ho5n7vbsuthmd7gi 615 8 64 64 CD work_zbi2knhp65ho5n7vbsuthmd7gi 615 9 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 615 10 PMID:7612192 PMID:7612192 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 615 11 ; ; , work_zbi2knhp65ho5n7vbsuthmd7gi 615 12 http://dx.doi.org/10.1515/ http://dx.doi.org/10.1515/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 615 13 bchm3.1995.376.3.157 bchm3.1995.376.3.157 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 615 14 92 92 CD work_zbi2knhp65ho5n7vbsuthmd7gi 615 15 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 616 1 Levicar Levicar NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 2 N N NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 3 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 616 4 Dewey Dewey NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 5 R R NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 6 A A NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 7 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 616 8 Daley Daley NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 9 E E NNS work_zbi2knhp65ho5n7vbsuthmd7gi 616 10 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 616 11 Bates Bates NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 12 TE TE NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 13 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 616 14 Davies Davies NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 15 D D NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 16 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 616 17 Kos Kos NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 18 J J NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 19 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 616 20 Pilkington Pilkington NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 21 GJ GJ NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 22 , , , work_zbi2knhp65ho5n7vbsuthmd7gi 616 23 Lah Lah NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 24 TT TT NNP work_zbi2knhp65ho5n7vbsuthmd7gi 616 25 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 617 1 Selective selective JJ work_zbi2knhp65ho5n7vbsuthmd7gi 617 2 sup- sup- JJ work_zbi2knhp65ho5n7vbsuthmd7gi 617 3 pression pression NN work_zbi2knhp65ho5n7vbsuthmd7gi 617 4 of of IN work_zbi2knhp65ho5n7vbsuthmd7gi 617 5 cathepsin cathepsin NNP work_zbi2knhp65ho5n7vbsuthmd7gi 617 6 L L NNP work_zbi2knhp65ho5n7vbsuthmd7gi 617 7 by by IN work_zbi2knhp65ho5n7vbsuthmd7gi 617 8 antisense antisense NNP work_zbi2knhp65ho5n7vbsuthmd7gi 617 9 cDNA cDNA NNP work_zbi2knhp65ho5n7vbsuthmd7gi 617 10 impairs impairs NNP work_zbi2knhp65ho5n7vbsuthmd7gi 617 11 human human NNP work_zbi2knhp65ho5n7vbsuthmd7gi 617 12 brain brain NNP work_zbi2knhp65ho5n7vbsuthmd7gi 617 13 tumor tumor NN work_zbi2knhp65ho5n7vbsuthmd7gi 617 14 cell cell NN work_zbi2knhp65ho5n7vbsuthmd7gi 617 15 invasion invasion NN work_zbi2knhp65ho5n7vbsuthmd7gi 617 16 in in IN work_zbi2knhp65ho5n7vbsuthmd7gi 617 17 vitro vitro FW work_zbi2knhp65ho5n7vbsuthmd7gi 617 18 and and CC work_zbi2knhp65ho5n7vbsuthmd7gi 617 19 pro- pro- NN work_zbi2knhp65ho5n7vbsuthmd7gi 617 20 motes mote VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 617 21 apoptosis apoptosis NN work_zbi2knhp65ho5n7vbsuthmd7gi 617 22 . . . work_zbi2knhp65ho5n7vbsuthmd7gi 618 1 Cancer Cancer NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 2 Gene Gene NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 3 Ther Ther NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 4 2003 2003 CD work_zbi2knhp65ho5n7vbsuthmd7gi 618 5 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 618 6 10:141- 10:141- NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 7 51 51 CD work_zbi2knhp65ho5n7vbsuthmd7gi 618 8 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 618 9 PMID:12536203 PMID:12536203 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 10 ; ; : work_zbi2knhp65ho5n7vbsuthmd7gi 618 11 http://dx.doi.org/10.1038/ http://dx.doi.org/10.1038/ ADD work_zbi2knhp65ho5n7vbsuthmd7gi 618 12 sj.cgt.7700546 sj.cgt.7700546 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 13 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18097482&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=18097482&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 14 http://dx.doi.org/10.1172/JCI33700 http://dx.doi.org/10.1172/JCI33700 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 15 http://dx.doi.org/10.1172/JCI33700 http://dx.doi.org/10.1172/JCI33700 . work_zbi2knhp65ho5n7vbsuthmd7gi 618 16 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=15122344&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=15122344&dopt=abstract JJ work_zbi2knhp65ho5n7vbsuthmd7gi 618 17 http://dx.doi.org/10.1038/sj.onc.1207645 http://dx.doi.org/10.1038/sj.onc.1207645 FW work_zbi2knhp65ho5n7vbsuthmd7gi 618 18 http://dx.doi.org/10.1038/sj.onc.1207645 http://dx.doi.org/10.1038/sj.onc.1207645 NN work_zbi2knhp65ho5n7vbsuthmd7gi 618 19 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9234744&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9234744&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 20 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9234744&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=9234744&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 21 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11895924&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11895924&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 22 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11003670&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11003670&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 23 http://dx.doi.org/10.1128/MCB.20.20.7751-7763.2000 http://dx.doi.org/10.1128/mcb.20.20.7751-7763.2000 UH work_zbi2knhp65ho5n7vbsuthmd7gi 618 24 http://dx.doi.org/10.1128/MCB.20.20.7751-7763.2000 http://dx.doi.org/10.1128/MCB.20.20.7751-7763.2000 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 25 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20213841&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=20213841&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 26 http://dx.doi.org/10.1002/em.20552 http://dx.doi.org/10.1002/em.20552 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 27 http://dx.doi.org/10.1002/em.20552 http://dx.doi.org/10.1002/em.20552 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 28 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22252008&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22252008&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 29 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22252008&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22252008&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 30 http://dx.doi.org/10.4161/auto.8.2.18554 http://dx.doi.org/10.4161/auto.8.2.18554 NN work_zbi2knhp65ho5n7vbsuthmd7gi 618 31 http://dx.doi.org/10.4161/auto.8.2.18554 http://dx.doi.org/10.4161/auto.8.2.18554 NNS work_zbi2knhp65ho5n7vbsuthmd7gi 618 32 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22215907&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22215907&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 33 http://dx.doi.org/10.1158/1078-0432.CCR-11-1000 http://dx.doi.org/10.1158/1078-0432.CCR-11-1000 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 34 http://dx.doi.org/10.1158/1078-0432.CCR-11-1000 http://dx.doi.org/10.1158/1078-0432.CCR-11-1000 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 35 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21838681&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=21838681&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 36 http://dx.doi.org/10.2174/092986711797189574 http://dx.doi.org/10.2174/092986711797189574 PRP work_zbi2knhp65ho5n7vbsuthmd7gi 618 37 http://dx.doi.org/10.2174/092986711797189574 http://dx.doi.org/10.2174/092986711797189574 CD work_zbi2knhp65ho5n7vbsuthmd7gi 618 38 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=13677373&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=13677373&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 39 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11853690&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11853690&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 40 http://dx.doi.org/10.1016/S0006-2952(01)00878-4 http://dx.doi.org/10.1016/s0006-2952(01)00878-4 FW work_zbi2knhp65ho5n7vbsuthmd7gi 618 41 http://dx.doi.org/10.1016/S0006-2952(01)00878-4 http://dx.doi.org/10.1016/s0006-2952(01)00878-4 FW work_zbi2knhp65ho5n7vbsuthmd7gi 618 42 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17113554&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17113554&dopt=Abstract . work_zbi2knhp65ho5n7vbsuthmd7gi 618 43 http://dx.doi.org/10.1016/j.actatropica.2006.10.007 http://dx.doi.org/10.1016/j.actatropica.2006.10.007 NN work_zbi2knhp65ho5n7vbsuthmd7gi 618 44 http://dx.doi.org/10.1016/j.actatropica.2006.10.007 http://dx.doi.org/10.1016/j.actatropica.2006.10.007 NN work_zbi2knhp65ho5n7vbsuthmd7gi 618 45 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8885219&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=8885219&dopt=abstract $ work_zbi2knhp65ho5n7vbsuthmd7gi 618 46 http://dx.doi.org/10.1016/0166-6851(96)02655-2 http://dx.doi.org/10.1016/0166-6851(96)02655-2 PRP work_zbi2knhp65ho5n7vbsuthmd7gi 618 47 http://dx.doi.org/10.1016/0166-6851(96)02655-2 http://dx.doi.org/10.1016/0166-6851(96)02655-2 . work_zbi2knhp65ho5n7vbsuthmd7gi 618 48 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22073285&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22073285&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 49 http://dx.doi.org/10.1371/journal.pone.0027197 http://dx.doi.org/10.1371/journal.pone.0027197 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 50 http://dx.doi.org/10.1371/journal.pone.0027197 http://dx.doi.org/10.1371/journal.pone.0027197 VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 618 51 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17361129&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=17361129&dopt=abstract VB work_zbi2knhp65ho5n7vbsuthmd7gi 618 52 http://dx.doi.org/10.1038/sj.clpt.6100122 http://dx.doi.org/10.1038/sj.clpt.6100122 NN work_zbi2knhp65ho5n7vbsuthmd7gi 618 53 http://dx.doi.org/10.1038/sj.clpt.6100122 http://dx.doi.org/10.1038/sj.clpt.6100122 NN work_zbi2knhp65ho5n7vbsuthmd7gi 618 54 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=22084530&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=retrieve&db=pubmed&list_uids=22084530&dopt=abstract ADD work_zbi2knhp65ho5n7vbsuthmd7gi 618 55 http://dx.doi.org/10.2471/BLT.11.087320 http://dx.doi.org/10.2471/BLT.11.087320 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 56 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19809895&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19809895&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 57 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19809895&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=19809895&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 58 http://dx.doi.org/10.1007/s12192-009-0145-6 http://dx.doi.org/10.1007/s12192-009-0145-6 NN work_zbi2knhp65ho5n7vbsuthmd7gi 618 59 http://dx.doi.org/10.1007/s12192-009-0145-6 http://dx.doi.org/10.1007/s12192-009-0145-6 NN work_zbi2knhp65ho5n7vbsuthmd7gi 618 60 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7612192&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=7612192&dopt=Abstract VBZ work_zbi2knhp65ho5n7vbsuthmd7gi 618 61 http://dx.doi.org/10.1515/bchm3.1995.376.3.157 http://dx.doi.org/10.1515/bchm3.1995.376.3.157 NN work_zbi2knhp65ho5n7vbsuthmd7gi 618 62 http://dx.doi.org/10.1515/bchm3.1995.376.3.157 http://dx.doi.org/10.1515/bchm3.1995.376.3.157 NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 63 http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12536203&dopt=Abstract http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12536203&dopt=Abstract NNP work_zbi2knhp65ho5n7vbsuthmd7gi 618 64 http://dx.doi.org/10.1038/sj.cgt.7700546 http://dx.doi.org/10.1038/sj.cgt.7700546 PRP work_zbi2knhp65ho5n7vbsuthmd7gi 618 65 http://dx.doi.org/10.1038/sj.cgt.7700546 http://dx.doi.org/10.1038/sj.cgt.7700546 -LRB-