[PDF] Overcoming an energy crisis?: an adaptive role of glycogen synthase kinase-3 inhibition in ischemia/reperfusion. | Semantic Scholar Skip to search formSkip to main content> Semantic Scholar's Logo Search Sign InCreate Free Account You are currently offline. Some features of the site may not work correctly. DOI:10.1161/01.RES.0000338259.37472.b6 Corpus ID: 7027199Overcoming an energy crisis?: an adaptive role of glycogen synthase kinase-3 inhibition in ischemia/reperfusion. @article{Zhai2008OvercomingAE, title={Overcoming an energy crisis?: an adaptive role of glycogen synthase kinase-3 inhibition in ischemia/reperfusion.}, author={P. Zhai and J. Sadoshima}, journal={Circulation research}, year={2008}, volume={103 9}, pages={ 910-3 } } P. Zhai, J. Sadoshima Published 2008 Medicine, Biology Circulation research A prolonged period of ischemia leads to death of cardiac myocyte (myocardial infarction). In theory, quicker restoration of blood supply to the ischemic myocardium should reduce the extent of myocardial injury. However, reperfusion itself has the potential to exacerbate myocardial damage, a phenomenon known as reperfusion injury. Mitochondrial dysfunction plays a central role in mediating myocardial cell death by ischemia/reperfusion (IR). In particular, opening of the mitochondria permeability… Expand View on PubMed ahajournals.org Save to Library Create Alert Cite Launch Research Feed Share This Paper 14 CitationsHighly Influential Citations 2 Background Citations 7 View All Topics from this paper Adenosine Triphosphate Glycogen Synthase Kinase 3 Glycogen Synthase Kinases Hypoxia Ischemia Adenine Nucleotides Creatine Glycolysis Glycogen (Starch) Synthase Reperfusion Injury Glucose Myocytes, Cardiac Cardiomyopathies Reperfusion Therapy Mitochondrial Membranes Myocardial Infarction Cessation of life Benzodiazepines Threonine Mitochondrial Diseases Voltage-Dependent Anion Channels Cell Death 1-Phosphatidylinositol 3-Kinase Reactive Oxygen Species Oxidative Stress 14 Citations Citation Type Citation Type All Types Cites Results Cites Methods Cites Background Has PDF Publication Type Author More Filters More Filters Filters Sort by Relevance Sort by Most Influenced Papers Sort by Citation Count Sort by Recency Inhibition of glycogen synthase kinase 3β prevents NSAID-induced acute kidney injury H. 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