AJPH2009168971_Koenen 2433..2441 Pervasive Trauma Exposure Among US Sexual Orientation Minority Adults and Risk of Posttraumatic Stress Disorder Andrea L. Roberts, PhD, S. Bryn Austin, ScD, Heather L. Corliss, PhD, Ashley K. Vandermorris, MD, and Karestan C. Koenen, PhD Sexual orientation disparities in exposure to violence over the life course are well docu- mented.1–10 Individuals with minority sexual orientation (e.g., gay, lesbian, bisexual) report elevated frequency, severity, and persistence of physical and sexual abuse in childhood.1,3,4 Throughout their lives, sexual orientation mi- norities are more likely to experience violence in their communities, including hate crimes.5,10–12 Intimate partner violence and sexual assault in adulthood are also disproportionately prevalent among sexual orientation minorities.3,9 It is unknown whether sexual orientation disparities also exist in exposure to other types of potentially traumatic events. Despite the growing recognition of sexual orientation disparities in violence exposure, population-representative research examining possible sexual orientation differences in risk of posttraumatic stress disorder (PTSD) is very limited. PTSD is a mental disorder that de- velops in response to exposure to a potentially traumatic event, including violence (e.g., child- hood abuse, sexual assault) or other negative life experiences (e.g., disasters, accidents). The disorder is characterized by persistent reex- periencing of the event, persistent avoidance of stimuli associated with the event, emotional numbing, and hyperarousal. For PTSD diagnosis according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria, symptoms must be present for at least 1 month and result in functional impairment.13 The public health consequences of PTSD are staggering and include secondary mental dis- orders, substance dependence,14,15 impaired role functioning, health problems,16–18 and re- duced life course opportunities (e.g., higher rates of unemployment).19 The lack of data on PTSD among sexual orientation minorities is a critical gap because, of all civilian traumas, interpersonal violence is associated with the highest condi- tional risk of developing PTSD.20,21 We examined sexual orientation disparities in expo- sure to violence and other potentially traumatic events and in risk of PTSD in a US representative sample. Previous studies have found elevated rates of PTSD among sexual orientation minorities in comparison with heterosexuals.6,10,22,23 How- ever, our understanding of the burden of PTSD in this vulnerable population is constrained by 3 limitations of extant research. First, as far as we know, only 1 study compared rates of PTSD across sexual orientation groups in a nationally representative sample.23 Several studies relied on convenience samples; selection factors in such samples could bias observed associations among sexual orientation, violence exposure, and PTSD. Second, the only study of sexual orienta- tion and PTSD in a nationally representative sample categorized members into a sexual orientation group solely by reports of the gender of their sexual partners. Other dimensions of sexual orientation, such as sexual orientation identity and feelings of sexual attraction, which have been shown to be important correlates of physical and mental health,24,25 were not mea- sured. Third, no previous study attempted to link possible sexual orientation disparities in PTSD directly to elevated risk of exposure to violence and other traumatic events in the minority sexual orientation population. Type of potentially trau- matic event exposure—particularly elevated rates of exposure to violence, exposure to multi- ple events, and younger age at exposure—are all important determinants of PTSD20,21,26–28 that may account for the disparities in PTSD by sexual orientation. We designed our study to document the public health burden of potentially traumatic Objectives. We assessed sexual orientation disparities in exposure to violence and other potentially traumatic events and onset of posttraumatic stress disorder (PTSD) in a representative US sample. Methods. We used data from 34 653 noninstitutionalized adult US residents from the 2004 to 2005 wave of the National Epidemiologic Survey on Alcohol and Related Conditions. Results. Lesbians and gay men, bisexuals, and heterosexuals who reported any same-sex sexual partners over their lifetime had greater risk of childhood maltreatment, interpersonal violence, trauma to a close friend or relative, and unexpected death of someone close than did heterosexuals with no same-sex attractions or partners. Risk of onset of PTSD was higher among lesbians and gays (adjusted odds ratio [AOR] = 2.03; 95% confidence interval [CI] = 1.34, 3.06), bisexuals (AOR = 2.13; 95% CI = 1.38, 3.29), and heterosexuals with any same-sex partners (AOR = 2.06; 95% CI = 1.54, 2.74) than it was among the heterosexual reference group. This higher risk was largely accounted for by sexual orientation minorities’ greater exposure to violence, exposure to more potentially traumatic events, and earlier age of trauma exposure. Conclusions. Profound sexual orientation disparities exist in risk of PTSD and in violence exposure, beginning in childhood. Our findings suggest there is an urgent need for public health interventions aimed at preventing violence against individuals with minority sexual orientations and providing follow-up care to cope with the sequelae of violent victimization. (Am J Public Health. 2010;100: 2433–2441. doi:10.2105/AJPH.2009.168971) RESEARCH AND PRACTICE December 2010, Vol 100, No. 12 | American Journal of Public Health Roberts et al. | Peer Reviewed | Research and Practice | 2433 event exposure and PTSD in US residents with minority sexual orientations. We analyzed data from the National Epidemiologic Survey on Alcohol and Related Conditions (NESARC), a large, nationally representative survey of US adults.29 Respondents were asked to report on 3 dimensions of sexual orientation: identity (i.e., heterosexual, gay, lesbian, or bisexual), same-sex and opposite-sex attractions, and same-sex and opposite-sex sexual partners. We also investi- gated the causes of observed disparities in PTSD by analyzing NESARC’s detailed information on type of traumatic events and age at first exposure. These are therefore the most comprehensive data reported to date, derived from a nationally representative sample and aimed at quantifying disparities in potentially traumatic events and associated PTSD by sexual orientation. METHODS We analyzed data from Wave 2 (2004– 2005) of NESARC, a nationally representative survey of 34 653 adult US residents (86.7% response rate). NESARC used a 3-stage, nested sampling design to obtain a representative sam- ple of the civilian, noninstitutionalized popula- tion aged 18 years and older residing in the United States.29 At Wave 2, respondents were aged 20 years or older; respondents aged 90 years or older were top-coded as age 90 years. Measures Violence, potentially traumatic events, and posttraumatic stress disorder. The National In- stitute on Alcohol Abuse and Alcoholism’s Alcohol Use Disorder and Associated Disabil- ities Interview Schedule from the DSM-IV30 was administered through computer-assisted, face-to-face interviews in respondents’ homes by trained US Census Bureau workers31,32 to assess lifetime experience of violence, other traumatic events, and PTSD. Participants were asked about 27 specific types of potentially traumatic events. We excluded 1 event, indirect exposure to a terrorist attack through watching TV or listening to the radio, from our analysis because its status as a PTSD–level event is controversial. We grouped the potentially trau- matic events into 6 major categories for sub- sequent analyses33,34: childhood maltreatment (3 items), interpersonal violence (6 items), war-related traumas (4 items), other injury or shocking event (7 items), learning of a trauma to a close friend or relative (5 items), and learning of an unexpected death (1 item). Age at first exposure to violence or mal- treatment in childhood was the earliest age the respondent reported for any of the 6 interper- sonal violence or 3 childhood maltreatment events, if younger than 18 years. Sexual orien- tation differences in these childhood experi- ences are important to assess because these events carry a high risk for PTSD14; thus our findings could better identify developmental periods in which public health interventions are needed and could inform clinicians treating children and adolescents. Each respondent who reported any trau- matic event was asked to identify his or her worst event. We diagnosed PTSD resulting from this event based on reported symptoms according to DSM-IV criteria.13 This required that respondents with a worst trauma confirm experiencing each of 6 conditions: (1) extreme feelings of fear, helplessness, or horror during the event; (2) at least 1 persistent reexperiencing symptom; (3) 3 avoidance or emotional numb- ness symptoms; (4) 2 hyperarousal symptoms; (5) symptoms lasting more than 1 month; and (6) functional impairment resulting from these symptoms. Sexual orientation. Sexual orientation was assessed after the questions about traumatic events and PTSD through items regarding 3 dimensions: identity, attraction, and sex of sexual partners. Respondents chose the sexual orientation identity category that best de- scribed them: heterosexual, gay or lesbian, bisexual, or not sure. Respondents were also asked about their feelings of sexual attraction: only attracted to females, mostly attracted to females, equally attracted to males and females, mostly attracted to males, and only attracted to males. Finally, respondents were asked about the sex of their lifetime sexual partners: whether they had had sex with only males, only females, both, or had never had sex. We classified individuals into 5 categories of sexual orientation, primarily by their sexual orientation identity (heterosexual, lesbian/gay, bisexual). We prioritized sexual orientation identity because studies suggest it is more strongly related to mental health and victimi- zation than is attraction or behavior.35–38 We further classified the heterosexual category into 3 subgroups based on sexual attraction and sexual partners: heterosexual with no same-sex attrac- tion or partners (reference group), heterosexual with same-sex attraction but no same-sex part- ners, and heterosexual with same-sex partners. Subdividing lesbian–gay and bisexual groups according to attraction and sexual partners was not possible because of small sample size. We excluded from our analysis 170 re- spondents (0.49%) who were unsure of their sexual orientation identity and 415 respon- dents (1.20%) who did not respond to 1 of the sexual orientation questions. Compared with the analytic sample, excluded respondents were somewhat older (mean age = 53.3 years; SE =1.06 versus mean age = 48.1 years; SE = 0.17), were more likely to be women (60.1% versus 52.0%; P = .007), and had lower educational attainment (P < .001), but did not differ in race/ethnicity. With regard to expo- sure to potentially traumatic events and con- ditional risk of PTSD, respondents who reported being unsure of their sexual orienta- tion were largely similar to heterosexuals with no same-sex attraction or partners. Many re- spondents with missing sexual orientation information were also missing data on trau- matic events and PTSD; therefore, it was not possible to determine whether these outcomes differed from those of the heterosexuals with no same-sex attraction or partners. Mediators. We considered 3 potential medi- ators of the association between sexual orien- tation and PTSD. Worst trauma type was determined according to the 6 categories we delineated from the interview questions. Age at worst trauma was divided into 4 categories: 11 years or younger, 12 to 17 years, 18 to 29 years, and 30 years or older. The third medi- ator was the number of potentially traumatic event types respondents reported experiencing prior to their worst trauma. Total number of previous potentially traumatic events could not be assessed from NESARC data. Demographic covariates. Following a US Census Bureau algorithm, NESARC classified respondents by self-report of their racial/ethnic origin to 1 race/ethnicity in the following preferential order: Hispanic, non-Hispanic Black, non-Hispanic American Indian/Native Alaskan, non-Hispanic Native Hawaiian/Pacific Islander, non-Hispanic Asian, and non-Hispanic RESEARCH AND PRACTICE 2434 | Research and Practice | Peer Reviewed | Roberts et al. American Journal of Public Health | December 2010, Vol 100, No. 12 White.39 Educational attainment was catego- rized as less than high school diploma, high school diploma, some college, and college degree or higher. Categories for age at interview were 20 to 29 years, 30 to 39 years, 40 to 49 years, 50 to 59 years, and 60 years or older. Analyses To investigate whether individuals with mi- nority sexual orientation were at greater risk of exposure to violence and other potentially traumatic events than were heterosexuals with no same-sex attractions or sexual partners, we examined with the c2 test lifetime exposure to the 6 categories of events, lifetime exposure to specific events, and differences in violence exposure or maltreatment when younger than 18 years, by sexual orientation stratified by gender. Next, to test whether our proposed mediators differed by sexual orientation, we compared with the Wald test mean age at worst trauma and mean number of event types prior to worst trauma. Finally, to take into account the different ages of the respondents and to adjust for potential confounders, we conducted 7 discrete time survival analyses by sexual orientation, with age at first occurrence of any event and each of the 6 major types of events as the outcomes. Respondents who did not report events were censored at age at interview. Each model adjusted for gender, race/ethnicity, age at interview, and educational attainment. In models where gender–by–sexual orientation interaction terms were significant, we reported results stratified by gender. To examine whether individuals with mi- nority sexual orientation were more likely to develop PTSD following potentially traumatic event exposure, we compared lifetime preva- lence of PTSD among individuals exposed to an event, by sexual orientation stratified by gen- der. Next, to adjust for potential confounders and test for potential mediators, we constructed 3 logistic regression models estimating the odds of onset of PTSD among respondents exposed to a potentially traumatic event. In the base model, we looked at sexual orientation as the main predictor, adjusting for gender, race/ ethnicity, age at interview, and educational attainment. In model 2, we included the po- tential mediator of worst trauma type to see whether differences in type of event experi- enced accounted for differences in odds of PTSD among sexual orientation groups. In model 3, we added 2 more potential mediators, age at worst trauma, and number of event types prior to worst trauma. Because gender–by– sexual orientation interaction terms were not significant, we combined men and women in these models. All analyses were conducted with SUDAAN software40 to account for the nested sampling design of the NESARC study, which may have resulted in correlated responses, and to weight the data so that it reflected the US population.29 RESULTS The lifetime prevalence of potentially trau- matic event exposure (80.5% of women; 81.1% of men) and PTSD (10.4% of women; 4.3% of men) was consistent with that found in other epidemiologic studies that used DSM-IV crite- ria.28,41 The prevalence of sexual orientation groups was, for men, 93.9% heterosexual with no same-sex attractions or sexual partners, 1.8% heterosexual with same-sex attraction only, 2.4% heterosexual with same-sex partners, 1.1% gay, 0.4% bisexual; for women, 92.0% heterosexual with no same-sex attractions or partners, 4.6% heterosexual with same-sex attraction only, 1.5% heterosexual with same-sex partners, 0.7% les- bian, and 0.8% bisexual. Prevalence of Exposure to Potentially Traumatic Events by Gender Table 1 presents lifetime exposure to each of the 6 trauma event categories and individual events among women by sexual orientation. Lesbians, bisexual women, and heterosexual women with same-sex partners reported higher prevalence of childhood maltreatment, inter- personal violence, other injury or shocking event, and learning of trauma to a close friend or relative than did heterosexual women with no same-sex attraction or partners. The preva- lence of childhood maltreatment in lesbians (27.6%) and bisexual women (30.5%) was roughly twice that in the reference group (13.1%). Even more striking were the results for interpersonal violence. Heterosexual women with same-sex partners, lesbians, and bisexual women had significantly higher prevalence of nearly every kind of interpersonal violence than did the reference group, with the majority of lesbians (60.2%) and bisexual women (54.1%) reporting at least 1 experience of in- terpersonal violence; only 26.6% of the refer- ence group had such experiences. Lesbians (44.0%) and bisexual women (47.3%) also reported higher rates of unwanted sex than did the reference group (13.4%). Figure 1 shows that childhood exposure to maltreatment or interpersonal violence was significantly more prevalent among heterosex- ual women with same-sex partners (40.9%), lesbians (49.2%), and bisexuals (51.2%) than it was among the reference group (21.2%). Het- erosexual women with same-sex attraction had higher prevalence of war-related events but lower prevalence of any trauma, learning of trauma to a close friend or relative, and un- expected death of someone close than did the reference group. Table 2 presents lifetime exposure to each of the 6 trauma event categories and individual events among men by sexual orientation. Gay men and heterosexual men with same-sex partners reported significantly higher preva- lence of interpersonal violence and learning of a trauma to a close friend or relative than did the reference group. Experiencing unwanted sex was considerably more common among heterosexual men with any lifetime male sexual partners (12.7%), gay men (18.0%), and bi- sexual men (12.0%) than among the reference group (2.2%). Gay men, compared with the reference group, also had significantly elevated rates of almost every type of interpersonal violence, including domestic violence (11.5% versus 2.0%), being beaten up (20.7% versus 11.7%), being mugged (27.5% versus 16.2%), and being stalked (8.1% versus 2.6%). Het- erosexual men with same-sex attraction had prevalence similar to the reference group for each of the 6 major categories of potentially traumatic events. Figure 1 shows that child- hood exposure to violence or maltreatment was also higher among gay men (31.5%) and heterosexual men with same-sex partners (27.9%) than it was among the reference group (19.8%). Characteristics of Event Exposure as Mediators of Posttraumatic Stress Disorder Age at worst trauma was significantly youn- ger among heterosexuals with same-sex RESEARCH AND PRACTICE December 2010, Vol 100, No. 12 | American Journal of Public Health Roberts et al. | Peer Reviewed | Research and Practice | 2435 partners (mean = 29.0 years; SE = 0.8), gays and lesbians (mean = 26.5 years; SE = 0.9), and bisexuals (mean = 24.0 years; SE =1.1) than it was among the reference group (mean = 31.6 years; SE = 0.2), but significantly older in het- erosexuals with same-sex attractions only (mean = 35.9 years; SE = 0.8). We also observed sexual orientation dis- parities in number of event types prior to worst trauma. Heterosexuals with same-sex partners (mean =1.8; SE = 0.10) and gay men and les- bians (mean =1.9; SE = 0.10) reported significantly higher numbers of previous event types than did the reference group (mean =1.3; SE = 0.01). Heterosexuals with same-sex at- traction only (mean =1.4; SE = 0.07) did not differ significantly from the reference group. Multivariate Analyses for Potentially Traumatic Events In discrete time survival models for any potentially traumatic event and the 6 cate- gories of events that adjusted for gender, race/ ethnicity, age at interview, and educational attainment, heterosexuals with same-sex part- ners, gay men and lesbians, and bisexuals had significantly higher risk of exposure to any event, childhood maltreatment, and trauma to a close friend or relative than did the reference group. Sexual orientation disparities were substan- tial for both childhood maltreatment and in- terpersonal violence. Gay men, lesbians, and bisexuals had more than twice the risk of childhood maltreatment (gay men and lesbians, adjusted odds ratio [AOR] = 2.18; 95% TABLE 1—Prevalence of Posttraumatic Stress Disorder (PTSD) and Potentially Traumatic Event Exposure Among Women (N = 19 717), by Sexual Orientation: United States, 2004–2005 Heterosexual Lesbian (n = 145), % (SE) Bisexual (n = 161), % (SE) No Same-Sex Attraction or Sexual Partners (n = 18144), % (SE) Same-Sex Attraction Only (n = 953), % (SE) Same-Sex Sexual Partners (n = 314), % (SE) PTSD prevalence among women exposed to a potentially traumatic event 12.50 (0.39) 11.62 (1.35) 22.78** (3.13) 18.04 (4.07) 25.68** (4.66) Any potentially traumatic event 80.48 (0.65) 76.79* (1.67) 87.42** (2.98) 88.92** (2.65) 86.25 (3.03) Childhood maltreatment 13.07 (0.35) 13.91 (1.38) 19.55* (2.73) 27.64** (4.83) 30.52*** (4.07) Physical abuse 3.81 (0.18) 3.53 (0.61) 6.44 (1.63) 11.27 (4.13) 11.11** (2.55) Neglect 3.26 (0.16) 3.26 (0.75) 6.51 (1.68) 12.36* (4.13) 8.72* (2.28) Witness to domestic violence 10.90 (0.33) 10.85 (1.26) 14.34 (2.05) 22.01* (4.80) 25.44** (4.07) Interpersonal violence 26.36 (0.51) 28.35 (1.82) 46.30*** (3.46) 60.21*** (4.98) 54.06*** (4.38) Unwanted sex 13.41 (0.42) 15.89 (1.53) 29.57*** (3.21) 43.98*** (4.92) 47.26*** (4.67) Victim of domestic violence 9.44 (0.29) 9.62 (1.20) 23.81*** (3.02) 16.10 (3.82) 20.17** (3.60) Attacked/beaten up 3.46 (0.17) 4.51 (0.80) 12.88*** (2.18) 10.37* (2.90) 20.73*** (3.96) Kidnapped 0.93 (0.08) 0.48* (0.21) 3.53* (1.12) 3.14 (1.56) 2.90 (1.47) Stalked 7.62 (0.29) 8.67 (1.08) 18.37*** (2.64) 14.21 (4.84) 16.64** (3.11) Mugged 7.27 (0.28) 8.21 (1.14) 16.91*** (2.32) 13.65* (3.09) 17.41* (3.81) Other injury or shocking event 43.89 (0.59) 46.83 (2.23) 61.12*** (2.98) 57.43** (4.55) 54.89* (4.47) Serious or life-threatening accident 11.55 (0.35) 14.79* (1.61) 23.35*** (2.81) 15.94 (4.00) 17.01 (3.80) Serious or life-threatening illness 16.41 (0.39) 17.76 (1.56) 25.05* (3.48) 22.44 (4.53) 12.90 (2.78) Natural disaster 13.44 (0.61) 15.29 (1.68) 21.87** (2.79) 10.41 (2.87) 16.83 (3.15) Terrorist attacka 0.60 (0.09) 0.50 (0.29) 1.11 (0.74) 0.24 (0.24) 1.36 (0.98) Saw someone injured/killed/discovered a dead body 16.13 (0.38) 14.10 (1.42) 29.20*** (3.12) 29.39** (4.57) 30.76** (4.30) War-related trauma 2.29 (0.19) 3.68* (0.67) 7.91** (1.91) 3.97 (1.77) 0.89 (0.89) Learned of trauma to close friend or relative 55.12 (0.76) 48.58** (2.41) 62.12* (3.42) 65.42* (4.52) 64.62* (4.16) Close friend or relative experienced serious or life-threatening accident or injury 49.50 (0.78) 43.62* (2.45) 55.26 (3.48) 61.10* (4.74) 61.09* (4.27) Close friend or relative experienced terrorist attacka 4.92 (0.42) 4.81 (0.91) 6.22 (1.70) 7.12 (2.20) 4.84 (1.94) Close friend or relative experienced other stressful or traumatic experience 14.77 (0.36) 12.45 (1.37) 23.15** (2.84) 16.95 (4.14) 27.90** (3.99) Learned of unexpected death 42.52 (0.74) 35.02 (2.07)b 45.79 (3.45) 52.98 (5.10) 49.97 (4.76) aDetermined by 3 questions in interview. *P < .05; **P < .01; ***P < .001; for statistically significant difference in prevalence of potentially traumatic event from reference group, heterosexuals with no same-sex attraction or sexual partners, by the c2 test. RESEARCH AND PRACTICE 2436 | Research and Practice | Peer Reviewed | Roberts et al. American Journal of Public Health | December 2010, Vol 100, No. 12 confidence interval [CI] =1.59, 2.99; bisexuals, AOR = 2.16; 95% CI =1.59, 2.93) than did the reference group. Risk of interpersonal violence was significantly higher than it was in the reference groups for all female sexual orienta- tion minority groups (heterosexual women with same-sex attraction, AOR =1.24; 95% CI =1.06, 1.46; heterosexual women with same-sex partners, AOR =1.93; 95% CI =1.57, 2.37; lesbians, AOR = 2.80; 95% CI = 2.12, 3.70; bisexual women, AOR = 2.56; 95% CI =1.96, 3.34), gay men (AOR = 2.29; 95% CI =1.79, 2.94), and heterosexual men with same-sex partners (AOR =1.51; 95% CI =1.22,1.88). Only heterosexuals with same-sex attractions did not have higher risk of childhood mal- treatment and had significantly lower risk of other injury or shocking event (AOR = 0.92; 95% CI = 0.85, 0.99) and unexpected death of someone close (AOR = 0.84; 95% CI = 0.75, 0.95). Multivariate Analyses for Posttraumatic Stress Disorder Among individuals exposed to a potentially traumatic event, heterosexual men and women with same-sex partners, bisexual women, and gay men had approximately twice the lifetime risk of PTSD as did the reference group (Tables 1 and 2). Table 3 presents the AORs for developing PTSD among people exposed to an event. In a model adjusting for gender, race/ ethnicity, education, and age at interview (model 1), heterosexuals with same-sex partners (AOR = 2.06; 95% CI =1.54, 2.74), lesbians and gay men (AOR = 2.03; 95% CI =1.34, 3.06), and bisexuals (AOR = 2.13; 95% CI = 1.38, 3.29) had greater odds of developing PTSD than did heterosexuals without same-sex attraction or partners. Adding worst event type to the model attenuated but did not fully explain this re- lationship (model 2). Adding age at worst event and number of trauma types prior to worst trauma further attenuated the relationship between sexual orientation and PTSD risk to nonsignificance for bisexuals and lesbians and gay men (model 3). However, in the full model the odds were still significantly higher for heterosexuals with same-sex partners (AOR = 1.59; 95% CI =1.16, 2.18) than for the refer- ence group. DISCUSSION Ours is the first analysis of national popula- tion-based data to document the link between sexual orientation disparities in exposure to multiple types of violence and other potentially traumatic events, and the increased risk of PTSD among sexual orientation minorities compared with heterosexuals without same-sex attraction or partners. Our key findings are that (1) lesbians, gay men, bisexuals, and hetero- sexuals with same-sex sexual partners—but not heterosexuals with same-sex attraction only—- had significantly elevated risk of exposure to nearly every event type except war-related traumas; (2) sexual orientation disparities in event exposure were greatest for childhood maltreatment and interpersonal violence; (3) lesbians and gay men, bisexuals, and hetero- sexuals with same-sex partners experienced their worst event at a younger age; (4) the 2 types of trauma for which sexual orientation minorities were most differentially at risk (interpersonal violence and childhood abuse or neglect) were also most strongly associated with PTSD onset of all the trauma types; and (5) sexual orientation disparities in PTSD were almost completely accounted for by differential traumatic event exposure, including type, age at worst event, and number of event types prior to the worst event. The sexual orientation disparities in violence exposure were striking. In these data, gay men, lesbians, and bisexual women were twice as likely as were the heterosexual reference group to be exposed to violence. Some proportion of the increased risk of violence exposure among sexual orientation minorities may in- volve bias or hate crimes, although the NESARC data did not allow us to examine the motivations of perpetrators of violence against sexual orientation minority participants. According to the Federal Bureau of Investiga- tion’s 2002 report on crime in the United States, 16.4% of all single-bias hate crimes were motivated by prejudice against the victim’s sexual orientation,42 and 32% of gay men, lesbians, and bisexuals reported having been personally targeted for violence against their person or property because of their sexual orientation in a recent US study.43 Sexual ori- entation disparities in violence exposure are likely 1 manifestation of the larger problem of discrimination and bias against sexual minorities in the United States. In addition to antigay hate (or bias) crimes, we posit 5 other mechanisms by which sexual orientation minorities could experience high rates of victimization and PTSD. First, sexual minorities may be more likely to exhibit be- haviors that do not conform to gender expec- tations, beginning in early childhood.44 Such behaviors have consistently been found to be associated with increased risk of victimization and rejection as well as poorer physical and mental health.22,45–53 Thus, such nonconformist behavior may partly account for the high prev- alence of maltreatment and interpersonal violence before age 12 years among sexual orientation minorities in our sample. Second, sexual minorities may experience social isolation Note. The sample size was N = 34 068. *P < .05; for statistically significant difference from heterosexual, by the c2 test. FIGURE 1—Childhood maltreatment or interpersonal violence, by sexual orientation, gender, and age at first occurrence: United States, 2004–2005. RESEARCH AND PRACTICE December 2010, Vol 100, No. 12 | American Journal of Public Health Roberts et al. | Peer Reviewed | Research and Practice | 2437 and distress if they perceive themselves to belong to a stigmatized group. Internalized stressors stemming from stigma, social isolation, discrimi- nation, and HIV/AIDS may put sexual orienta- tion minorities at higher risk for developing PTSD if exposed to a potentially traumatic event.54–58 Third, elevated rates of risk-taking behavior related to social isolation and psychological distress, especially substance use,35,59 may exacerbate risk for interpersonal violence, other traumatic events, and PTSD. Fourth, fewer resources to cope with traumatic events, such as lower levels of social support60–62 and less access to mental health care,63–65 may lead to higher rates of PTSD once exposed to an event. Finally, childhood traumas may influence how some individuals express their sexual orientation, although no studies to date support this pathway. We were unable to examine these factors in the NESARC data. However, sexual orientation disparities in PTSD were largely accounted for by characteristics of potentially traumatic event exposure, suggesting that event exposure plays a major role in observed disparities in PTSD. The finding that heterosexuals with same- sex attraction but not same-sex sexual partners did not have elevated risk of exposure to most events or higher risk of PTSD compared with the reference group is novel, because research on this group is in its infancy. We can speculate that heterosexuals without lifetime same-sex partners may be exposed to lower levels of internal and external stigma than are hetero- sexuals with same-sex partners, gay men, TABLE 2—Prevalence of Posttraumatic Stress Disorder (PTSD) and Potentially Traumatic Event Exposure Among Men (N = 14 351), by Sexual Orientation: United States, 2004–2005 Heterosexual Gay (n = 190), % (SE) Bisexual (n = 81), % (SE) No Same-Sex Attraction or Sexual Partners (n = 13422), % (SE) Same-Sex Attraction Only (n = 293), % (SE) Same-Sex Sexual Partners (n = 365), % (SE) PTSD prevalence among men exposed to a potentially traumatic event 5.03 (0.23) 7.04 (1.77) 10.13* (2.07) 13.38** (2.82) 9.00 (4.26) Any potentially traumatic event 80.84 (0.61) 83.68 (2.53) 88.43*** (2.03) 85.20 (3.30) 75.61 (6.50) Childhood maltreatment 10.76 (0.36) 10.47 (2.01) 14.98 (2.20) 18.26 (3.75) 12.15 (4.05) Physical abuse 2.95 (0.17) 1.33* (0.63) 4.92 (1.24) 5.26 (1.88) 8.70 (3.67) Neglect 2.51 (0.17) 3.69 (1.30) 2.99 (0.92) 11.56* (3.24) 6.20 (3.21) Witness to domestic violence 8.76 (0.32) 7.53 (1.72) 12.61 (2.01) 11.42 (2.80) 9.16 (3.52) Interpersonal violence 24.95 (0.48) 20.97 (2.81) 33.98** (2.77) 50.69*** (4.00) 31.05 (3.69) Unwanted sex 2.23 (1.17) 2.91 (1.06) 12.71*** (2.00) 17.95*** (3.36) 12.04* (4.04) Victim of domestic violence 2.00 (0.15) 1.53 (0.79) 3.97 (1.06) 11.52** (3.00) 0 Attacked/beaten up 11.73 (0.35) 10.39 (2.38) 16.64 (2.48) 20.70* (3.61) 10.42 (3.40) Kidnapped 0.67 (0.08) 0 0.81 (0.43) 2.92 (2.11) 1.08 (1.08) Stalked 2.55 (0.16) 2.33 (0.99) 6.03* (1.50) 8.12* (2.30) 5.15 (3.44) Mugged 16.21 (0.48) 11.57* (1.77) 19.36 (2.27) 27.47** (3.77) 20.71 (4.94) Other injury or shocking event 56.27 (0.65) 61.42 (3.72) 60.30 (3.20) 63.33 (4.60) 54.16 (6.46) Serious or life-threatening accident 21.72 (0.46) 18.70 (2.58) 22.12 (2.71) 20.10 (3.25) 22.40 (4.81) Serious or life-threatening illness 17.05 (0.50) 22.73* (2.53) 22.69 (2.94) 25.66 (4.89) 33.15** (5.79) Natural disaster 18.04 (0.70) 16.25 (2.30) 18.21 (2.50) 20.40 (4.29) 8.77* (3.69) Terrorist attacka 1.25 (0.14) 1.41 (0.88) 2.02 (0.84) 4.51 (1.83) 0 Saw someone injured/killed/discovered a dead body 32.45 (0.63) 34.28 (3.19) 34.74 (3.05) 23.96* (3.66) 33.07 (6.03) War-related trauma 13.13 (0.40) 16.72 (3.02) 11.33 (1.77) 5.76** (1.84) 8.35 (3.10) Learned of trauma to close friend or relative 49.51 (0.70) 47.01 (3.20) 59.52** (3.27) 71.73*** (4.50) 50.64 (5.92) Close friend or relative experienced serious or life-threatening accident or injury 43.50 (0.74) 43.37 (3.32) 54.78** (3.33) 60.26** (4.93) 42.74 (5.71) Close friend or relative experienced terrorist attacka 5.57 (0.40) 3.39 (1.16) 6.05 (1.46) 14.17* (3.08) 3.36 (1.72) Close friend or relative experienced other stressful or traumatic experience 12.71 (0.36) 11.07 (1.97) 15.75 (2.32) 27.04** (4.76) 11.04 (4.07) Learned of unexpected death 41.21 (0.79) 40.19 (3.62) 48.57* (3.23) 45.69 (4.12) 43.37 (7.09) aDetermined by 3 questions in interview. *P < .05: **P < .01; ***P < .001 (statistically significant difference in prevalence of potentially traumatic event from reference group, heterosexuals with no same-sex attraction or sexual partners, by the c2 test). RESEARCH AND PRACTICE 2438 | Research and Practice | Peer Reviewed | Roberts et al. American Journal of Public Health | December 2010, Vol 100, No. 12 lesbians, and bisexuals,66 and therefore may be less likely to be targeted in bias crimes, may engage in fewer risk-taking behaviors, and may have better social support and access to mental health care. Our findings should be interpreted in the context of 3 limitations. First, we relied on retrospective reporting of event exposure, age of event exposure, and PTSD symptoms, which may have resulted in lower prevalence esti- mates of events and illness than would re- peated contemporaneous reporting67,68 and may have attenuated true associations.69 Second, reporting bias may have inflated our findings if willingness to report a stigmatized sexual orien- tation on a survey was associated with greater willingness to report other stigmatizing informa- tion (e.g., history of violence victimization).4 Third, conducting multiple tests of statistical significance may have led to results that were statistically significant by chance.70,71 Although the majority of individuals with a minority sexual orientation are mentally healthy, medical professionals need to be aware that a high percentage of patients with minority sexual orientation may have been victims of interpersonal violence and may benefit from follow-up care to cope with the sequelae of violent victimization. Adolescents’ health care providers should also note that adolescents who identify as lesbian, gay, bisexual, or who report same-sex sexual part- ners may have histories of abuse, neglect, or violent victimization and may require addi- tional services or intervention if their exposure to violence or child abuse is ongoing. j About the Authors Andrea L. Roberts, S. Bryn Austin, and Karestan C. Koenen are with the Department of Society, Human Development, and Health, School of Public Health, Harvard University, Boston, MA. Karestan C. Koenen is also with the De- partment of Epidemiology, School of Public Health, Harvard University, Boston, MA. S. Bryn Austin and Heather L. Corliss are with the Division of Adolescent/ Young Adult Medicine, Children’s Hospital, Boston, MA. Ashley K. Vandermorris is with the Faculty of Medicine, Department of Paediatrics, University of Toronto, Canada. Correspondence should be sent to Karestan C. Koenen, Harvard School of Public Health, 677 Huntington Ave, Kresge 613, Boston, MA 02115 (e-mail: kkoenen@hsph. harvard.edu). Reprints can be ordered at http://www.ajph. org by clicking the ‘‘Reprints/Eprints’’ link. This article was accepted October 12, 2009. Contributors A. L. Roberts, S. B. Austin, H. L. Corliss, and K. C. Koenen contributed to designing the analytic approach, data analysis and interpretation, and drafting and revising the article. A. K. Vandermorris contributed to review of relevant literature and to drafting and revising the article. K. C. Koenen originated the study. Acknowledgments A. L. Roberts is supported by the Harvard Training Program in Psychiatric Genetics and Translational Re- search (grant T32MH017119). S. B. Austin and H. L. Corliss are supported by the US Maternal and Child Health Bureau, Health Resources and Services Adminis- tration (grant T71-MC00009-17). H. L. Corliss is also supported by the National Institute on Drug Abuse (grant K01 DA023610). K. C. Koenen is supported by the National Institute of Mental Health (grants K08MH070627 and 5R01MH078928). Human Participant Protection Because this study used de-identified data, no protocol approval was needed. References 1. Austin SB, Jun HJ, Jackson B, et al. Disparities in child abuse victimization in lesbian, bisexual, and heterosexual women in the Nurses’ Health Study II. J Womens Health (Larchmt). 2008;17(4):597–606. 2. Austin SB, Roberts AL, Corliss HL, Molnar BE. Sexual violence victimization history and sexual risk indicators in a community-based urban cohort of ‘‘mostly hetero- sexual’’ and heterosexual young women. Am J Public Health. 2008;98(6):1015–1020. 3. Balsam KF, Rothblum ED, Beauchaine TP. Victimi- zation over the life span: a comparison of lesbian, gay, bisexual, and heterosexual siblings. J Consult Clin Psychol. 2005;73(3):477–487. 4. Corliss HL, Cochran SD, Mays VM. 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