CCR-13-2847 6352..6352 From the Editor On Masterpieces and Breast Cancer Research The artist Henri Matisse captured the essence of a problem we often have in science—those landmark discoveries that bench- mark the type of progress we think we should be continuously making. This edition of CCR Focus presents instead an alter- native view of discovery and progress, one in which a steady expansion of our understanding of the biology of breast cancer has led to progress on multiple fronts. In the past decade, we have come to see breast cancer not as one disease but as comprising multiple diseases, a significant step over the 1970s era classification as estrogen receptor (ER)–positive or –negative. A breast cancer diagnosis of luminal A or B, HER2, basal-like, or normal-like subtype may eventually be more important than ER status. Notably, the gene expression profiles of all the molecular subtypes can be found within the triple- negative category, and additional profiles identified, as dis- cussed by Turner and Reis-Filho. To reach its potential, such classification needs, of course, separate therapies for each subtype. Tabchy and colleagues note that the PIK3CA muta- tion is most common in ERþ/luminal tumors, highlighting a potential target in that subset for which drugs are already in development. Progress in other areas is discussed as well— Bardia and Baselga argue for pathologic complete response as an early endpoint in neoadjuvant therapy to evaluate new therapies. Two articles put renewed emphasis on the tumor microenvironment. Zhang and colleagues look at potential targets in the microenvironment that support tumor dorman- cy, allowing metastatic disease to emerge years after all evi- dence of the tumor has disappeared. Disis and Stanton move beyond the evidence that the infiltration of a breast tumor with immune effector cells portends an improved outlook to show how we might engage the immune system in breast cancer therapeutics. Lin and colleagues discuss the problem of central nervous system recurrence in breast cancer. This represents an emerging problem that can be directly tied to success in controlling or eradicating systemic disease. Introduced by our expert Guest Editor, Carlos Arteaga, these articles highlight the many challenges that remain in developing truly effective breast cancer treatment. For now, the collective efforts in breast cancer represent a work in progress. Someday, these advances will constitute a masterpiece. Susan E. Bates Deputy Editor, CCR Focus National Cancer Institute I was very embarrassed when my canvases began to fetch high prices, I saw myself condemned to a future of painting nothing but masterpieces. —Henri Matisse Figure 1. Cambodian postage stamp, issued in 1999, showing Crockery on a Table by Henri Matisse (1869–1954), � Blue Moon/Fotolia. Published online December 2, 2013. doi: 10.1158/1078-0432.CCR-13-2847 �2013 American Association for Cancer Research. CCR FOCUS Clin Cancer Res; 19(23) December 1, 20136352 on April 5, 2021. © 2013 American Association for Cancer Research. clincancerres.aacrjournals.org Downloaded from http://clincancerres.aacrjournals.org/ 2013;19:6352. Clin Cancer Res Susan E. Bates On Masterpieces and Breast Cancer Research Updated version http://clincancerres.aacrjournals.org/content/19/23/6352 Access the most recent version of this article at: E-mail alerts related to this article or journal.Sign up to receive free email-alerts Subscriptions Reprints and .pubs@aacr.org To order reprints of this article or to subscribe to the journal, contact the AACR Publications Department at Permissions Rightslink site. 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