id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_axhrql3nyvgufbncfxh2g3pd2m	Marika Bogdani	Thinking Outside the Cell: A Key Role for Hyaluronan in the Pathogenesis of Human Type 1 Diabetes	2016.0	10	.pdf	application/pdf	8003	694	51	Thinking Outside the Cell: A Key Role for Hyaluronan in the Pathogenesis of Human Type 1 Diabetes Migrating immune and damaged parenchymal cells at the site of inflammation release inflammatory mediators that affect the expression of different of islet immune cell infiltration in human insulitis are still Studies in tissue specimens from patients with type 1 diabetes show that the b-cell mass is reduced at the time the and collagen showed that these components of the periislet BM were lost at sites of leukocyte infiltration in islets in NOD mice and in pancreata from type 1 diabetes Figure 1—HA accumulates in human pancreatic islets and insulitis areas and in PLN in type 1 diabetes. Figure 2—Proposed model for the role of islet HA in the regulation of insulitis and b-cell damage in type 1 diabetes. Hyaluronan and hyaluronanbinding proteins accumulate in both human type 1 diabetic islets and lymphoid	./cache/work_axhrql3nyvgufbncfxh2g3pd2m.pdf	./txt/work_axhrql3nyvgufbncfxh2g3pd2m.txt