id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_lq642obedfh7vevpgdmg7wzc7u	Miles F. Wilkinson	Genetic paradox explained by nonsense	2019.0	2	.pdf	application/pdf	2452	254	71	and in the Department of Physics, University The authors identify a molecular mechanism that activates the transcription of genes such a genetic compensation response was initially suggested by earlier studies, most notably the discovery3 that knockout of the eg fl7 upregulation of compensatory genes is specifically triggered by mutations that generate short Gene mutations that truncate the encoded protein can trigger the expression of NITC is the PTC-bearing mRNA generated trigger transcriptional upregulation of genes of the upf1 gene prevented NITC, whereas that NITC requires the Upf3a protein, an enigmatic NMD factor that was previously shown10 Both research groups identified some specific mutant genes and mutations proteins indirectly activate the expression of related genes, to provide functional compensation. trigger mRNA degradation by a process called nonsense-mediated RNA decay (NMD), which both interacts with COMPASS — a protein complex that activates gene transcription by modifying one of the 	./cache/work_lq642obedfh7vevpgdmg7wzc7u.pdf	./txt/work_lq642obedfh7vevpgdmg7wzc7u.txt