id sid tid token lemma pos work_4qabwxy7effildblswnw7mkrvi 1 1 Dollco Dollco NNP work_4qabwxy7effildblswnw7mkrvi 1 2 S S NNP work_4qabwxy7effildblswnw7mkrvi 1 3 implify implify NNP work_4qabwxy7effildblswnw7mkrvi 1 4 , , , work_4qabwxy7effildblswnw7mkrvi 1 5 simplify simplify VB work_4qabwxy7effildblswnw7mkrvi 1 6 , , , work_4qabwxy7effildblswnw7mkrvi 1 7 simplify simplify NNP work_4qabwxy7effildblswnw7mkrvi 1 8 ! ! . work_4qabwxy7effildblswnw7mkrvi 2 1 So so RB work_4qabwxy7effildblswnw7mkrvi 2 2 instructed instruct VBD work_4qabwxy7effildblswnw7mkrvi 2 3 the the DT work_4qabwxy7effildblswnw7mkrvi 2 4 philosopher philosopher NN work_4qabwxy7effildblswnw7mkrvi 2 5 Henry Henry NNP work_4qabwxy7effildblswnw7mkrvi 2 6 David David NNP work_4qabwxy7effildblswnw7mkrvi 2 7 Thoreau Thoreau NNP work_4qabwxy7effildblswnw7mkrvi 2 8 , , , work_4qabwxy7effildblswnw7mkrvi 2 9 who who WP work_4qabwxy7effildblswnw7mkrvi 2 10 believed believe VBD work_4qabwxy7effildblswnw7mkrvi 2 11 a a DT work_4qabwxy7effildblswnw7mkrvi 2 12 life life NN work_4qabwxy7effildblswnw7mkrvi 2 13 lived live VBD work_4qabwxy7effildblswnw7mkrvi 2 14 simply simply RB work_4qabwxy7effildblswnw7mkrvi 2 15 was be VBD work_4qabwxy7effildblswnw7mkrvi 2 16 a a DT work_4qabwxy7effildblswnw7mkrvi 2 17 life life NN work_4qabwxy7effildblswnw7mkrvi 2 18 better well RBR work_4qabwxy7effildblswnw7mkrvi 2 19 lived live VBD work_4qabwxy7effildblswnw7mkrvi 2 20 , , , work_4qabwxy7effildblswnw7mkrvi 2 21 in in IN work_4qabwxy7effildblswnw7mkrvi 2 22 his -PRON- PRP$ work_4qabwxy7effildblswnw7mkrvi 2 23 157-year 157-year CD work_4qabwxy7effildblswnw7mkrvi 2 24 - - HYPH work_4qabwxy7effildblswnw7mkrvi 2 25 old old JJ work_4qabwxy7effildblswnw7mkrvi 2 26 classic classic JJ work_4qabwxy7effildblswnw7mkrvi 2 27 book book NN work_4qabwxy7effildblswnw7mkrvi 2 28 Walden Walden NNP work_4qabwxy7effildblswnw7mkrvi 2 29 . . . work_4qabwxy7effildblswnw7mkrvi 3 1 These these DT work_4qabwxy7effildblswnw7mkrvi 3 2 words word NNS work_4qabwxy7effildblswnw7mkrvi 3 3 also also RB work_4qabwxy7effildblswnw7mkrvi 3 4 seem seem VBP work_4qabwxy7effildblswnw7mkrvi 3 5 apropos apropos NN work_4qabwxy7effildblswnw7mkrvi 3 6 in in IN work_4qabwxy7effildblswnw7mkrvi 3 7 the the DT work_4qabwxy7effildblswnw7mkrvi 3 8 increasingly increasingly RB work_4qabwxy7effildblswnw7mkrvi 3 9 complex complex JJ work_4qabwxy7effildblswnw7mkrvi 3 10 world world NN work_4qabwxy7effildblswnw7mkrvi 3 11 of of IN work_4qabwxy7effildblswnw7mkrvi 3 12 health health NN work_4qabwxy7effildblswnw7mkrvi 3 13 care care NN work_4qabwxy7effildblswnw7mkrvi 3 14 , , , work_4qabwxy7effildblswnw7mkrvi 3 15 where where WRB work_4qabwxy7effildblswnw7mkrvi 3 16 making make VBG work_4qabwxy7effildblswnw7mkrvi 3 17 care care NN work_4qabwxy7effildblswnw7mkrvi 3 18 simpler simple JJR work_4qabwxy7effildblswnw7mkrvi 3 19 for for IN work_4qabwxy7effildblswnw7mkrvi 3 20 patients patient NNS work_4qabwxy7effildblswnw7mkrvi 3 21 has have VBZ work_4qabwxy7effildblswnw7mkrvi 3 22 been be VBN work_4qabwxy7effildblswnw7mkrvi 3 23 shown show VBN work_4qabwxy7effildblswnw7mkrvi 3 24 to to TO work_4qabwxy7effildblswnw7mkrvi 3 25 reap reap VB work_4qabwxy7effildblswnw7mkrvi 3 26 benefits benefit NNS work_4qabwxy7effildblswnw7mkrvi 3 27 . . . work_4qabwxy7effildblswnw7mkrvi 4 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 4 2 One one CD work_4qabwxy7effildblswnw7mkrvi 4 3 way way NN work_4qabwxy7effildblswnw7mkrvi 4 4 to to TO work_4qabwxy7effildblswnw7mkrvi 4 5 get get VB work_4qabwxy7effildblswnw7mkrvi 4 6 around around IN work_4qabwxy7effildblswnw7mkrvi 4 7 the the DT work_4qabwxy7effildblswnw7mkrvi 4 8 com- com- NN work_4qabwxy7effildblswnw7mkrvi 4 9 plexity plexity NN work_4qabwxy7effildblswnw7mkrvi 4 10 issue issue NN work_4qabwxy7effildblswnw7mkrvi 4 11 is be VBZ work_4qabwxy7effildblswnw7mkrvi 4 12 to to TO work_4qabwxy7effildblswnw7mkrvi 4 13 make make VB work_4qabwxy7effildblswnw7mkrvi 4 14 a a DT work_4qabwxy7effildblswnw7mkrvi 4 15 drug drug NN work_4qabwxy7effildblswnw7mkrvi 4 16 regimen regimen NN work_4qabwxy7effildblswnw7mkrvi 4 17 less less RBR work_4qabwxy7effildblswnw7mkrvi 4 18 complicated complicated JJ work_4qabwxy7effildblswnw7mkrvi 4 19 , , , work_4qabwxy7effildblswnw7mkrvi 4 20 ” " '' work_4qabwxy7effildblswnw7mkrvi 4 21 says say VBZ work_4qabwxy7effildblswnw7mkrvi 4 22 Dr. Dr. NNP work_4qabwxy7effildblswnw7mkrvi 4 23 Mark Mark NNP work_4qabwxy7effildblswnw7mkrvi 4 24 Fendrick Fendrick NNP work_4qabwxy7effildblswnw7mkrvi 4 25 , , , work_4qabwxy7effildblswnw7mkrvi 4 26 professor professor NN work_4qabwxy7effildblswnw7mkrvi 4 27 of of IN work_4qabwxy7effildblswnw7mkrvi 4 28 health health NNP work_4qabwxy7effildblswnw7mkrvi 4 29 manage- manage- NNP work_4qabwxy7effildblswnw7mkrvi 4 30 ment ment NN work_4qabwxy7effildblswnw7mkrvi 4 31 and and CC work_4qabwxy7effildblswnw7mkrvi 4 32 policy policy NN work_4qabwxy7effildblswnw7mkrvi 4 33 at at IN work_4qabwxy7effildblswnw7mkrvi 4 34 the the DT work_4qabwxy7effildblswnw7mkrvi 4 35 University University NNP work_4qabwxy7effildblswnw7mkrvi 4 36 of of IN work_4qabwxy7effildblswnw7mkrvi 4 37 Michigan Michigan NNP work_4qabwxy7effildblswnw7mkrvi 4 38 in in IN work_4qabwxy7effildblswnw7mkrvi 4 39 Ann Ann NNP work_4qabwxy7effildblswnw7mkrvi 4 40 Arbor Arbor NNP work_4qabwxy7effildblswnw7mkrvi 4 41 . . . work_4qabwxy7effildblswnw7mkrvi 5 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 5 2 How how WRB work_4qabwxy7effildblswnw7mkrvi 5 3 do do VBP work_4qabwxy7effildblswnw7mkrvi 5 4 you -PRON- PRP work_4qabwxy7effildblswnw7mkrvi 5 5 do do VB work_4qabwxy7effildblswnw7mkrvi 5 6 that that DT work_4qabwxy7effildblswnw7mkrvi 5 7 ? ? . work_4qabwxy7effildblswnw7mkrvi 6 1 You -PRON- PRP work_4qabwxy7effildblswnw7mkrvi 6 2 take take VBP work_4qabwxy7effildblswnw7mkrvi 6 3 two two CD work_4qabwxy7effildblswnw7mkrvi 6 4 pills pill NNS work_4qabwxy7effildblswnw7mkrvi 6 5 you -PRON- PRP work_4qabwxy7effildblswnw7mkrvi 6 6 take take VBP work_4qabwxy7effildblswnw7mkrvi 6 7 every every DT work_4qabwxy7effildblswnw7mkrvi 6 8 day day NN work_4qabwxy7effildblswnw7mkrvi 6 9 and and CC work_4qabwxy7effildblswnw7mkrvi 6 10 make make VB work_4qabwxy7effildblswnw7mkrvi 6 11 them -PRON- PRP work_4qabwxy7effildblswnw7mkrvi 6 12 into into IN work_4qabwxy7effildblswnw7mkrvi 6 13 one one CD work_4qabwxy7effildblswnw7mkrvi 6 14 . . . work_4qabwxy7effildblswnw7mkrvi 6 15 ” " '' work_4qabwxy7effildblswnw7mkrvi 6 16 As as IN work_4qabwxy7effildblswnw7mkrvi 6 17 the the DT work_4qabwxy7effildblswnw7mkrvi 6 18 burden burden NN work_4qabwxy7effildblswnw7mkrvi 6 19 of of IN work_4qabwxy7effildblswnw7mkrvi 6 20 chronic chronic JJ work_4qabwxy7effildblswnw7mkrvi 6 21 diseases disease NNS work_4qabwxy7effildblswnw7mkrvi 6 22 , , , work_4qabwxy7effildblswnw7mkrvi 6 23 which which WDT work_4qabwxy7effildblswnw7mkrvi 6 24 often often RB work_4qabwxy7effildblswnw7mkrvi 6 25 require require VBP work_4qabwxy7effildblswnw7mkrvi 6 26 multiple multiple JJ work_4qabwxy7effildblswnw7mkrvi 6 27 medica- medica- JJ work_4qabwxy7effildblswnw7mkrvi 6 28 tions tion NNS work_4qabwxy7effildblswnw7mkrvi 6 29 , , , work_4qabwxy7effildblswnw7mkrvi 6 30 increases increase NNS work_4qabwxy7effildblswnw7mkrvi 6 31 around around IN work_4qabwxy7effildblswnw7mkrvi 6 32 the the DT work_4qabwxy7effildblswnw7mkrvi 6 33 world world NN work_4qabwxy7effildblswnw7mkrvi 6 34 , , , work_4qabwxy7effildblswnw7mkrvi 6 35 the the DT work_4qabwxy7effildblswnw7mkrvi 6 36 appeal appeal NN work_4qabwxy7effildblswnw7mkrvi 6 37 of of IN work_4qabwxy7effildblswnw7mkrvi 6 38 fixed fix VBN work_4qabwxy7effildblswnw7mkrvi 6 39 - - HYPH work_4qabwxy7effildblswnw7mkrvi 6 40 dose dose NN work_4qabwxy7effildblswnw7mkrvi 6 41 combination combination NN work_4qabwxy7effildblswnw7mkrvi 6 42 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 6 43 may may MD work_4qabwxy7effildblswnw7mkrvi 6 44 also also RB work_4qabwxy7effildblswnw7mkrvi 6 45 increase increase VB work_4qabwxy7effildblswnw7mkrvi 6 46 . . . work_4qabwxy7effildblswnw7mkrvi 7 1 These these DT work_4qabwxy7effildblswnw7mkrvi 7 2 products product NNS work_4qabwxy7effildblswnw7mkrvi 7 3 , , , work_4qabwxy7effildblswnw7mkrvi 7 4 which which WDT work_4qabwxy7effildblswnw7mkrvi 7 5 combine combine VBP work_4qabwxy7effildblswnw7mkrvi 7 6 two two CD work_4qabwxy7effildblswnw7mkrvi 7 7 or or CC work_4qabwxy7effildblswnw7mkrvi 7 8 more more JJR work_4qabwxy7effildblswnw7mkrvi 7 9 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 7 10 into into IN work_4qabwxy7effildblswnw7mkrvi 7 11 a a DT work_4qabwxy7effildblswnw7mkrvi 7 12 single single JJ work_4qabwxy7effildblswnw7mkrvi 7 13 tablet tablet NN work_4qabwxy7effildblswnw7mkrvi 7 14 , , , work_4qabwxy7effildblswnw7mkrvi 7 15 have have VBP work_4qabwxy7effildblswnw7mkrvi 7 16 been be VBN work_4qabwxy7effildblswnw7mkrvi 7 17 shown show VBN work_4qabwxy7effildblswnw7mkrvi 7 18 time time NN work_4qabwxy7effildblswnw7mkrvi 7 19 and and CC work_4qabwxy7effildblswnw7mkrvi 7 20 again again RB work_4qabwxy7effildblswnw7mkrvi 7 21 to to TO work_4qabwxy7effildblswnw7mkrvi 7 22 increase increase VB work_4qabwxy7effildblswnw7mkrvi 7 23 adherence adherence NN work_4qabwxy7effildblswnw7mkrvi 7 24 to to IN work_4qabwxy7effildblswnw7mkrvi 7 25 drug drug NN work_4qabwxy7effildblswnw7mkrvi 7 26 regimens regimen NNS work_4qabwxy7effildblswnw7mkrvi 7 27 . . . work_4qabwxy7effildblswnw7mkrvi 8 1 In in IN work_4qabwxy7effildblswnw7mkrvi 8 2 one one CD work_4qabwxy7effildblswnw7mkrvi 8 3 study study NN work_4qabwxy7effildblswnw7mkrvi 8 4 , , , work_4qabwxy7effildblswnw7mkrvi 8 5 to to IN work_4qabwxy7effildblswnw7mkrvi 8 6 which which WDT work_4qabwxy7effildblswnw7mkrvi 8 7 Fendrick Fendrick NNP work_4qabwxy7effildblswnw7mkrvi 8 8 con- con- NN work_4qabwxy7effildblswnw7mkrvi 8 9 tributed tribute VBD work_4qabwxy7effildblswnw7mkrvi 8 10 , , , work_4qabwxy7effildblswnw7mkrvi 8 11 9170 9170 CD work_4qabwxy7effildblswnw7mkrvi 8 12 people people NNS work_4qabwxy7effildblswnw7mkrvi 8 13 with with IN work_4qabwxy7effildblswnw7mkrvi 8 14 diabetes diabete NNS work_4qabwxy7effildblswnw7mkrvi 8 15 were be VBD work_4qabwxy7effildblswnw7mkrvi 8 16 treated treat VBN work_4qabwxy7effildblswnw7mkrvi 8 17 either either CC work_4qabwxy7effildblswnw7mkrvi 8 18 with with IN work_4qabwxy7effildblswnw7mkrvi 8 19 two two CD work_4qabwxy7effildblswnw7mkrvi 8 20 medica- medica- JJ work_4qabwxy7effildblswnw7mkrvi 8 21 tions tion NNS work_4qabwxy7effildblswnw7mkrvi 8 22 or or CC work_4qabwxy7effildblswnw7mkrvi 8 23 with with IN work_4qabwxy7effildblswnw7mkrvi 8 24 a a DT work_4qabwxy7effildblswnw7mkrvi 8 25 fixed fix VBN work_4qabwxy7effildblswnw7mkrvi 8 26 - - HYPH work_4qabwxy7effildblswnw7mkrvi 8 27 dose dose NN work_4qabwxy7effildblswnw7mkrvi 8 28 combination combination NN work_4qabwxy7effildblswnw7mkrvi 8 29 product product NN work_4qabwxy7effildblswnw7mkrvi 8 30 ( ( -LRB- work_4qabwxy7effildblswnw7mkrvi 8 31 J J NNP work_4qabwxy7effildblswnw7mkrvi 8 32 Gen Gen NNP work_4qabwxy7effildblswnw7mkrvi 8 33 Intern Intern NNP work_4qabwxy7effildblswnw7mkrvi 8 34 Med Med NNP work_4qabwxy7effildblswnw7mkrvi 8 35 2008 2008 CD work_4qabwxy7effildblswnw7mkrvi 8 36 ; ; : work_4qabwxy7effildblswnw7mkrvi 8 37 23:611 23:611 CD work_4qabwxy7effildblswnw7mkrvi 8 38 - - SYM work_4qabwxy7effildblswnw7mkrvi 8 39 4 4 CD work_4qabwxy7effildblswnw7mkrvi 8 40 ) ) -RRB- work_4qabwxy7effildblswnw7mkrvi 8 41 . . . work_4qabwxy7effildblswnw7mkrvi 9 1 Adherence adherence NN work_4qabwxy7effildblswnw7mkrvi 9 2 to to IN work_4qabwxy7effildblswnw7mkrvi 9 3 the the DT work_4qabwxy7effildblswnw7mkrvi 9 4 drug drug NN work_4qabwxy7effildblswnw7mkrvi 9 5 regi- regi- NN work_4qabwxy7effildblswnw7mkrvi 9 6 men man NNS work_4qabwxy7effildblswnw7mkrvi 9 7 was be VBD work_4qabwxy7effildblswnw7mkrvi 9 8 12.8 12.8 CD work_4qabwxy7effildblswnw7mkrvi 9 9 % % NN work_4qabwxy7effildblswnw7mkrvi 9 10 higher high JJR work_4qabwxy7effildblswnw7mkrvi 9 11 in in IN work_4qabwxy7effildblswnw7mkrvi 9 12 the the DT work_4qabwxy7effildblswnw7mkrvi 9 13 group group NN work_4qabwxy7effildblswnw7mkrvi 9 14 that that WDT work_4qabwxy7effildblswnw7mkrvi 9 15 took take VBD work_4qabwxy7effildblswnw7mkrvi 9 16 a a DT work_4qabwxy7effildblswnw7mkrvi 9 17 single single JJ work_4qabwxy7effildblswnw7mkrvi 9 18 - - HYPH work_4qabwxy7effildblswnw7mkrvi 9 19 component component NN work_4qabwxy7effildblswnw7mkrvi 9 20 pill pill NN work_4qabwxy7effildblswnw7mkrvi 9 21 . . . work_4qabwxy7effildblswnw7mkrvi 10 1 A a DT work_4qabwxy7effildblswnw7mkrvi 10 2 meta meta JJ work_4qabwxy7effildblswnw7mkrvi 10 3 - - HYPH work_4qabwxy7effildblswnw7mkrvi 10 4 analysis analysis NN work_4qabwxy7effildblswnw7mkrvi 10 5 of of IN work_4qabwxy7effildblswnw7mkrvi 10 6 research research NN work_4qabwxy7effildblswnw7mkrvi 10 7 in in IN work_4qabwxy7effildblswnw7mkrvi 10 8 this this DT work_4qabwxy7effildblswnw7mkrvi 10 9 area area NN work_4qabwxy7effildblswnw7mkrvi 10 10 found find VBD work_4qabwxy7effildblswnw7mkrvi 10 11 an an DT work_4qabwxy7effildblswnw7mkrvi 10 12 even even RB work_4qabwxy7effildblswnw7mkrvi 10 13 greater great JJR work_4qabwxy7effildblswnw7mkrvi 10 14 positive positive JJ work_4qabwxy7effildblswnw7mkrvi 10 15 effect effect NN work_4qabwxy7effildblswnw7mkrvi 10 16 ( ( -LRB- work_4qabwxy7effildblswnw7mkrvi 10 17 Am Am NNP work_4qabwxy7effildblswnw7mkrvi 10 18 J J NNP work_4qabwxy7effildblswnw7mkrvi 10 19 Med Med NNP work_4qabwxy7effildblswnw7mkrvi 10 20 2007;120:713 2007;120:713 CD work_4qabwxy7effildblswnw7mkrvi 10 21 - - SYM work_4qabwxy7effildblswnw7mkrvi 10 22 9 9 CD work_4qabwxy7effildblswnw7mkrvi 10 23 ) ) -RRB- work_4qabwxy7effildblswnw7mkrvi 10 24 . . . work_4qabwxy7effildblswnw7mkrvi 11 1 Noncompliance noncompliance NN work_4qabwxy7effildblswnw7mkrvi 11 2 to to IN work_4qabwxy7effildblswnw7mkrvi 11 3 medication medication NN work_4qabwxy7effildblswnw7mkrvi 11 4 decreased decrease VBD work_4qabwxy7effildblswnw7mkrvi 11 5 by by IN work_4qabwxy7effildblswnw7mkrvi 11 6 26 26 CD work_4qabwxy7effildblswnw7mkrvi 11 7 % % NN work_4qabwxy7effildblswnw7mkrvi 11 8 when when WRB work_4qabwxy7effildblswnw7mkrvi 11 9 people people NNS work_4qabwxy7effildblswnw7mkrvi 11 10 took take VBD work_4qabwxy7effildblswnw7mkrvi 11 11 fixed fix VBN work_4qabwxy7effildblswnw7mkrvi 11 12 - - HYPH work_4qabwxy7effildblswnw7mkrvi 11 13 dose dose VBN work_4qabwxy7effildblswnw7mkrvi 11 14 combinations combination NNS work_4qabwxy7effildblswnw7mkrvi 11 15 for for IN work_4qabwxy7effildblswnw7mkrvi 11 16 conditions condition NNS work_4qabwxy7effildblswnw7mkrvi 11 17 such such JJ work_4qabwxy7effildblswnw7mkrvi 11 18 as as IN work_4qabwxy7effildblswnw7mkrvi 11 19 hypertension hypertension NN work_4qabwxy7effildblswnw7mkrvi 11 20 , , , work_4qabwxy7effildblswnw7mkrvi 11 21 HIV HIV NNP work_4qabwxy7effildblswnw7mkrvi 11 22 and and CC work_4qabwxy7effildblswnw7mkrvi 11 23 tuberculosis tuberculosis NN work_4qabwxy7effildblswnw7mkrvi 11 24 , , , work_4qabwxy7effildblswnw7mkrvi 11 25 states state VBZ work_4qabwxy7effildblswnw7mkrvi 11 26 the the DT work_4qabwxy7effildblswnw7mkrvi 11 27 paper paper NN work_4qabwxy7effildblswnw7mkrvi 11 28 , , , work_4qabwxy7effildblswnw7mkrvi 11 29 which which WDT work_4qabwxy7effildblswnw7mkrvi 11 30 concludes conclude VBZ work_4qabwxy7effildblswnw7mkrvi 11 31 with with IN work_4qabwxy7effildblswnw7mkrvi 11 32 a a DT work_4qabwxy7effildblswnw7mkrvi 11 33 recommendation recommendation NN work_4qabwxy7effildblswnw7mkrvi 11 34 for for IN work_4qabwxy7effildblswnw7mkrvi 11 35 increased increase VBN work_4qabwxy7effildblswnw7mkrvi 11 36 use use NN work_4qabwxy7effildblswnw7mkrvi 11 37 of of IN work_4qabwxy7effildblswnw7mkrvi 11 38 combination combination NN work_4qabwxy7effildblswnw7mkrvi 11 39 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 11 40 for for IN work_4qabwxy7effildblswnw7mkrvi 11 41 chronic chronic JJ work_4qabwxy7effildblswnw7mkrvi 11 42 illnesses illness NNS work_4qabwxy7effildblswnw7mkrvi 11 43 . . . work_4qabwxy7effildblswnw7mkrvi 12 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 12 2 The the DT work_4qabwxy7effildblswnw7mkrvi 12 3 pill pill NN work_4qabwxy7effildblswnw7mkrvi 12 4 burden burden NN work_4qabwxy7effildblswnw7mkrvi 12 5 becomes become VBZ work_4qabwxy7effildblswnw7mkrvi 12 6 an an DT work_4qabwxy7effildblswnw7mkrvi 12 7 issue issue NN work_4qabwxy7effildblswnw7mkrvi 12 8 for for IN work_4qabwxy7effildblswnw7mkrvi 12 9 a a DT work_4qabwxy7effildblswnw7mkrvi 12 10 patient patient NN work_4qabwxy7effildblswnw7mkrvi 12 11 , , , work_4qabwxy7effildblswnw7mkrvi 12 12 ” " '' work_4qabwxy7effildblswnw7mkrvi 12 13 says say VBZ work_4qabwxy7effildblswnw7mkrvi 12 14 Dr. Dr. NNP work_4qabwxy7effildblswnw7mkrvi 12 15 Franz Franz NNP work_4qabwxy7effildblswnw7mkrvi 12 16 Messerli Messerli NNP work_4qabwxy7effildblswnw7mkrvi 12 17 , , , work_4qabwxy7effildblswnw7mkrvi 12 18 one one CD work_4qabwxy7effildblswnw7mkrvi 12 19 of of IN work_4qabwxy7effildblswnw7mkrvi 12 20 the the DT work_4qabwxy7effildblswnw7mkrvi 12 21 paper paper NN work_4qabwxy7effildblswnw7mkrvi 12 22 ’s ’s POS work_4qabwxy7effildblswnw7mkrvi 12 23 authors author NNS work_4qabwxy7effildblswnw7mkrvi 12 24 and and CC work_4qabwxy7effildblswnw7mkrvi 12 25 the the DT work_4qabwxy7effildblswnw7mkrvi 12 26 director director NN work_4qabwxy7effildblswnw7mkrvi 12 27 of of IN work_4qabwxy7effildblswnw7mkrvi 12 28 the the DT work_4qabwxy7effildblswnw7mkrvi 12 29 hypertension hypertension NN work_4qabwxy7effildblswnw7mkrvi 12 30 program program NN work_4qabwxy7effildblswnw7mkrvi 12 31 at at IN work_4qabwxy7effildblswnw7mkrvi 12 32 the the DT work_4qabwxy7effildblswnw7mkrvi 12 33 St. St. NNP work_4qabwxy7effildblswnw7mkrvi 12 34 Luke’s Luke’s NNP work_4qabwxy7effildblswnw7mkrvi 12 35 – – : work_4qabwxy7effildblswnw7mkrvi 12 36 Roosevelt Roosevelt NNP work_4qabwxy7effildblswnw7mkrvi 12 37 Hospital Hospital NNP work_4qabwxy7effildblswnw7mkrvi 12 38 Cen- Cen- NNP work_4qabwxy7effildblswnw7mkrvi 12 39 ter ter NN work_4qabwxy7effildblswnw7mkrvi 12 40 in in IN work_4qabwxy7effildblswnw7mkrvi 12 41 New New NNP work_4qabwxy7effildblswnw7mkrvi 12 42 York York NNP work_4qabwxy7effildblswnw7mkrvi 12 43 City City NNP work_4qabwxy7effildblswnw7mkrvi 12 44 , , , work_4qabwxy7effildblswnw7mkrvi 12 45 New New NNP work_4qabwxy7effildblswnw7mkrvi 12 46 York York NNP work_4qabwxy7effildblswnw7mkrvi 12 47 . . . work_4qabwxy7effildblswnw7mkrvi 13 1 Fixed fix VBN work_4qabwxy7effildblswnw7mkrvi 13 2 - - HYPH work_4qabwxy7effildblswnw7mkrvi 13 3 dose dose NN work_4qabwxy7effildblswnw7mkrvi 13 4 combination combination NN work_4qabwxy7effildblswnw7mkrvi 13 5 products product NNS work_4qabwxy7effildblswnw7mkrvi 13 6 also also RB work_4qabwxy7effildblswnw7mkrvi 13 7 hold hold VBP work_4qabwxy7effildblswnw7mkrvi 13 8 great great JJ work_4qabwxy7effildblswnw7mkrvi 13 9 appeal appeal NN work_4qabwxy7effildblswnw7mkrvi 13 10 for for IN work_4qabwxy7effildblswnw7mkrvi 13 11 the the DT work_4qabwxy7effildblswnw7mkrvi 13 12 pharma- pharma- JJ work_4qabwxy7effildblswnw7mkrvi 13 13 ceutical ceutical JJ work_4qabwxy7effildblswnw7mkrvi 13 14 industry industry NN work_4qabwxy7effildblswnw7mkrvi 13 15 , , , work_4qabwxy7effildblswnw7mkrvi 13 16 suggests suggest VBZ work_4qabwxy7effildblswnw7mkrvi 13 17 Messerli Messerli NNP work_4qabwxy7effildblswnw7mkrvi 13 18 . . . work_4qabwxy7effildblswnw7mkrvi 14 1 It -PRON- PRP work_4qabwxy7effildblswnw7mkrvi 14 2 can can MD work_4qabwxy7effildblswnw7mkrvi 14 3 sometimes sometimes RB work_4qabwxy7effildblswnw7mkrvi 14 4 cost cost VB work_4qabwxy7effildblswnw7mkrvi 14 5 in in IN work_4qabwxy7effildblswnw7mkrvi 14 6 the the DT work_4qabwxy7effildblswnw7mkrvi 14 7 neighbour- neighbour- JJ work_4qabwxy7effildblswnw7mkrvi 14 8 hood hood NN work_4qabwxy7effildblswnw7mkrvi 14 9 of of IN work_4qabwxy7effildblswnw7mkrvi 14 10 US$ us$ $ work_4qabwxy7effildblswnw7mkrvi 14 11 1 1 CD work_4qabwxy7effildblswnw7mkrvi 14 12 billion billion CD work_4qabwxy7effildblswnw7mkrvi 14 13 to to TO work_4qabwxy7effildblswnw7mkrvi 14 14 bring bring VB work_4qabwxy7effildblswnw7mkrvi 14 15 a a DT work_4qabwxy7effildblswnw7mkrvi 14 16 new new JJ work_4qabwxy7effildblswnw7mkrvi 14 17 drug drug NN work_4qabwxy7effildblswnw7mkrvi 14 18 to to TO work_4qabwxy7effildblswnw7mkrvi 14 19 market market NN work_4qabwxy7effildblswnw7mkrvi 14 20 , , , work_4qabwxy7effildblswnw7mkrvi 14 21 he -PRON- PRP work_4qabwxy7effildblswnw7mkrvi 14 22 notes note VBZ work_4qabwxy7effildblswnw7mkrvi 14 23 , , , work_4qabwxy7effildblswnw7mkrvi 14 24 but but CC work_4qabwxy7effildblswnw7mkrvi 14 25 it -PRON- PRP work_4qabwxy7effildblswnw7mkrvi 14 26 may may MD work_4qabwxy7effildblswnw7mkrvi 14 27 cost cost VB work_4qabwxy7effildblswnw7mkrvi 14 28 only only RB work_4qabwxy7effildblswnw7mkrvi 14 29 a a DT work_4qabwxy7effildblswnw7mkrvi 14 30 quarter quarter NN work_4qabwxy7effildblswnw7mkrvi 14 31 of of IN work_4qabwxy7effildblswnw7mkrvi 14 32 that that DT work_4qabwxy7effildblswnw7mkrvi 14 33 to to TO work_4qabwxy7effildblswnw7mkrvi 14 34 release release VB work_4qabwxy7effildblswnw7mkrvi 14 35 a a DT work_4qabwxy7effildblswnw7mkrvi 14 36 combination combination NN work_4qabwxy7effildblswnw7mkrvi 14 37 of of IN work_4qabwxy7effildblswnw7mkrvi 14 38 existing exist VBG work_4qabwxy7effildblswnw7mkrvi 14 39 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 14 40 . . . work_4qabwxy7effildblswnw7mkrvi 15 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 15 2 It -PRON- PRP work_4qabwxy7effildblswnw7mkrvi 15 3 ’s ’ VBZ work_4qabwxy7effildblswnw7mkrvi 15 4 hard hard JJ work_4qabwxy7effildblswnw7mkrvi 15 5 to to TO work_4qabwxy7effildblswnw7mkrvi 15 6 come come VB work_4qabwxy7effildblswnw7mkrvi 15 7 up up RP work_4qabwxy7effildblswnw7mkrvi 15 8 with with IN work_4qabwxy7effildblswnw7mkrvi 15 9 new new JJ work_4qabwxy7effildblswnw7mkrvi 15 10 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 15 11 , , , work_4qabwxy7effildblswnw7mkrvi 15 12 ” " '' work_4qabwxy7effildblswnw7mkrvi 15 13 says say VBZ work_4qabwxy7effildblswnw7mkrvi 15 14 Messerli Messerli NNP work_4qabwxy7effildblswnw7mkrvi 15 15 . . . work_4qabwxy7effildblswnw7mkrvi 16 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 16 2 It -PRON- PRP work_4qabwxy7effildblswnw7mkrvi 16 3 ’s ’ VBZ work_4qabwxy7effildblswnw7mkrvi 16 4 easier easy JJR work_4qabwxy7effildblswnw7mkrvi 16 5 to to TO work_4qabwxy7effildblswnw7mkrvi 16 6 com- com- VB work_4qabwxy7effildblswnw7mkrvi 16 7 bine bine NN work_4qabwxy7effildblswnw7mkrvi 16 8 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 16 9 and and CC work_4qabwxy7effildblswnw7mkrvi 16 10 make make VB work_4qabwxy7effildblswnw7mkrvi 16 11 money money NN work_4qabwxy7effildblswnw7mkrvi 16 12 that that DT work_4qabwxy7effildblswnw7mkrvi 16 13 way way NN work_4qabwxy7effildblswnw7mkrvi 16 14 . . . work_4qabwxy7effildblswnw7mkrvi 16 15 ” " '' work_4qabwxy7effildblswnw7mkrvi 16 16 Of of RB work_4qabwxy7effildblswnw7mkrvi 16 17 course course RB work_4qabwxy7effildblswnw7mkrvi 16 18 , , , work_4qabwxy7effildblswnw7mkrvi 16 19 drug drug NN work_4qabwxy7effildblswnw7mkrvi 16 20 manufacturers manufacturer NNS work_4qabwxy7effildblswnw7mkrvi 16 21 that that WDT work_4qabwxy7effildblswnw7mkrvi 16 22 produce produce VBP work_4qabwxy7effildblswnw7mkrvi 16 23 combination combination NN work_4qabwxy7effildblswnw7mkrvi 16 24 products product NNS work_4qabwxy7effildblswnw7mkrvi 16 25 must must MD work_4qabwxy7effildblswnw7mkrvi 16 26 still still RB work_4qabwxy7effildblswnw7mkrvi 16 27 go go VB work_4qabwxy7effildblswnw7mkrvi 16 28 through through IN work_4qabwxy7effildblswnw7mkrvi 16 29 the the DT work_4qabwxy7effildblswnw7mkrvi 16 30 regular regular JJ work_4qabwxy7effildblswnw7mkrvi 16 31 approval approval NN work_4qabwxy7effildblswnw7mkrvi 16 32 process process NN work_4qabwxy7effildblswnw7mkrvi 16 33 , , , work_4qabwxy7effildblswnw7mkrvi 16 34 even even RB work_4qabwxy7effildblswnw7mkrvi 16 35 if if IN work_4qabwxy7effildblswnw7mkrvi 16 36 the the DT work_4qabwxy7effildblswnw7mkrvi 16 37 individual individual JJ work_4qabwxy7effildblswnw7mkrvi 16 38 compo- compo- NN work_4qabwxy7effildblswnw7mkrvi 16 39 nents nent NNS work_4qabwxy7effildblswnw7mkrvi 16 40 have have VBP work_4qabwxy7effildblswnw7mkrvi 16 41 already already RB work_4qabwxy7effildblswnw7mkrvi 16 42 been be VBN work_4qabwxy7effildblswnw7mkrvi 16 43 approved approve VBN work_4qabwxy7effildblswnw7mkrvi 16 44 for for IN work_4qabwxy7effildblswnw7mkrvi 16 45 sale sale NN work_4qabwxy7effildblswnw7mkrvi 16 46 . . . work_4qabwxy7effildblswnw7mkrvi 17 1 In in IN work_4qabwxy7effildblswnw7mkrvi 17 2 Canada Canada NNP work_4qabwxy7effildblswnw7mkrvi 17 3 , , , work_4qabwxy7effildblswnw7mkrvi 17 4 manufacturers manufacturer NNS work_4qabwxy7effildblswnw7mkrvi 17 5 must must MD work_4qabwxy7effildblswnw7mkrvi 17 6 submit submit VB work_4qabwxy7effildblswnw7mkrvi 17 7 the the DT work_4qabwxy7effildblswnw7mkrvi 17 8 same same JJ work_4qabwxy7effildblswnw7mkrvi 17 9 level level NN work_4qabwxy7effildblswnw7mkrvi 17 10 of of IN work_4qabwxy7effildblswnw7mkrvi 17 11 evidence evidence NN work_4qabwxy7effildblswnw7mkrvi 17 12 of of IN work_4qabwxy7effildblswnw7mkrvi 17 13 efficacy efficacy NN work_4qabwxy7effildblswnw7mkrvi 17 14 , , , work_4qabwxy7effildblswnw7mkrvi 17 15 safety safety NN work_4qabwxy7effildblswnw7mkrvi 17 16 and and CC work_4qabwxy7effildblswnw7mkrvi 17 17 quality quality NN work_4qabwxy7effildblswnw7mkrvi 17 18 as as IN work_4qabwxy7effildblswnw7mkrvi 17 19 for for IN work_4qabwxy7effildblswnw7mkrvi 17 20 single single JJ work_4qabwxy7effildblswnw7mkrvi 17 21 -component -component JJ work_4qabwxy7effildblswnw7mkrvi 17 22 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 17 23 . . . work_4qabwxy7effildblswnw7mkrvi 18 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 18 2 All all DT work_4qabwxy7effildblswnw7mkrvi 18 3 drug drug NN work_4qabwxy7effildblswnw7mkrvi 18 4 submissions submission NNS work_4qabwxy7effildblswnw7mkrvi 18 5 must must MD work_4qabwxy7effildblswnw7mkrvi 18 6 undergo undergo VB work_4qabwxy7effildblswnw7mkrvi 18 7 rigorous rigorous JJ work_4qabwxy7effildblswnw7mkrvi 18 8 scrutiny scrutiny NN work_4qabwxy7effildblswnw7mkrvi 18 9 and and CC work_4qabwxy7effildblswnw7mkrvi 18 10 satisfy satisfy VB work_4qabwxy7effildblswnw7mkrvi 18 11 scientific scientific JJ work_4qabwxy7effildblswnw7mkrvi 18 12 requirements requirement NNS work_4qabwxy7effildblswnw7mkrvi 18 13 under under IN work_4qabwxy7effildblswnw7mkrvi 18 14 the the DT work_4qabwxy7effildblswnw7mkrvi 18 15 Food Food NNP work_4qabwxy7effildblswnw7mkrvi 18 16 and and CC work_4qabwxy7effildblswnw7mkrvi 18 17 Drugs Drugs NNP work_4qabwxy7effildblswnw7mkrvi 18 18 Regulations Regulations NNPS work_4qabwxy7effildblswnw7mkrvi 18 19 , , , work_4qabwxy7effildblswnw7mkrvi 18 20 including include VBG work_4qabwxy7effildblswnw7mkrvi 18 21 those those DT work_4qabwxy7effildblswnw7mkrvi 18 22 for for IN work_4qabwxy7effildblswnw7mkrvi 18 23 fixed- fixed- JJ work_4qabwxy7effildblswnw7mkrvi 18 24 dose dose JJ work_4qabwxy7effildblswnw7mkrvi 18 25 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 18 26 , , , work_4qabwxy7effildblswnw7mkrvi 18 27 before before IN work_4qabwxy7effildblswnw7mkrvi 18 28 the the DT work_4qabwxy7effildblswnw7mkrvi 18 29 drug drug NN work_4qabwxy7effildblswnw7mkrvi 18 30 can can MD work_4qabwxy7effildblswnw7mkrvi 18 31 be be VB work_4qabwxy7effildblswnw7mkrvi 18 32 mar- mar- NNP work_4qabwxy7effildblswnw7mkrvi 18 33 keted kete VBN work_4qabwxy7effildblswnw7mkrvi 18 34 , , , work_4qabwxy7effildblswnw7mkrvi 18 35 ” " '' work_4qabwxy7effildblswnw7mkrvi 18 36 Olivia Olivia NNP work_4qabwxy7effildblswnw7mkrvi 18 37 Caron Caron NNP work_4qabwxy7effildblswnw7mkrvi 18 38 , , , work_4qabwxy7effildblswnw7mkrvi 18 39 media medium NNS work_4qabwxy7effildblswnw7mkrvi 18 40 relations relation NNS work_4qabwxy7effildblswnw7mkrvi 18 41 officer officer NN work_4qabwxy7effildblswnw7mkrvi 18 42 for for IN work_4qabwxy7effildblswnw7mkrvi 18 43 Health Health NNP work_4qabwxy7effildblswnw7mkrvi 18 44 Canada Canada NNP work_4qabwxy7effildblswnw7mkrvi 18 45 , , , work_4qabwxy7effildblswnw7mkrvi 18 46 writes write VBZ work_4qabwxy7effildblswnw7mkrvi 18 47 in in IN work_4qabwxy7effildblswnw7mkrvi 18 48 an an DT work_4qabwxy7effildblswnw7mkrvi 18 49 email email NN work_4qabwxy7effildblswnw7mkrvi 18 50 . . . work_4qabwxy7effildblswnw7mkrvi 19 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 19 2 The the DT work_4qabwxy7effildblswnw7mkrvi 19 3 choice choice NN work_4qabwxy7effildblswnw7mkrvi 19 4 of of IN work_4qabwxy7effildblswnw7mkrvi 19 5 a a DT work_4qabwxy7effildblswnw7mkrvi 19 6 primary primary JJ work_4qabwxy7effildblswnw7mkrvi 19 7 effi- effi- NN work_4qabwxy7effildblswnw7mkrvi 19 8 cacy cacy NN work_4qabwxy7effildblswnw7mkrvi 19 9 endpoint endpoint NN work_4qabwxy7effildblswnw7mkrvi 19 10 in in IN work_4qabwxy7effildblswnw7mkrvi 19 11 a a DT work_4qabwxy7effildblswnw7mkrvi 19 12 randomized randomized JJ work_4qabwxy7effildblswnw7mkrvi 19 13 clinical clinical JJ work_4qabwxy7effildblswnw7mkrvi 19 14 trial trial NN work_4qabwxy7effildblswnw7mkrvi 19 15 for for IN work_4qabwxy7effildblswnw7mkrvi 19 16 fixed fix VBN work_4qabwxy7effildblswnw7mkrvi 19 17 - - HYPH work_4qabwxy7effildblswnw7mkrvi 19 18 dose dose NN work_4qabwxy7effildblswnw7mkrvi 19 19 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 19 20 is be VBZ work_4qabwxy7effildblswnw7mkrvi 19 21 based base VBN work_4qabwxy7effildblswnw7mkrvi 19 22 on on IN work_4qabwxy7effildblswnw7mkrvi 19 23 the the DT work_4qabwxy7effildblswnw7mkrvi 19 24 same same JJ work_4qabwxy7effildblswnw7mkrvi 19 25 standards standard NNS work_4qabwxy7effildblswnw7mkrvi 19 26 established establish VBN work_4qabwxy7effildblswnw7mkrvi 19 27 for for IN work_4qabwxy7effildblswnw7mkrvi 19 28 sin- sin- JJ work_4qabwxy7effildblswnw7mkrvi 19 29 gle gle JJ work_4qabwxy7effildblswnw7mkrvi 19 30 component component NN work_4qabwxy7effildblswnw7mkrvi 19 31 products product NNS work_4qabwxy7effildblswnw7mkrvi 19 32 . . . work_4qabwxy7effildblswnw7mkrvi 19 33 ” " '' work_4qabwxy7effildblswnw7mkrvi 19 34 In in IN work_4qabwxy7effildblswnw7mkrvi 19 35 the the DT work_4qabwxy7effildblswnw7mkrvi 19 36 United United NNP work_4qabwxy7effildblswnw7mkrvi 19 37 States States NNP work_4qabwxy7effildblswnw7mkrvi 19 38 , , , work_4qabwxy7effildblswnw7mkrvi 19 39 manufacturers manufacturer NNS work_4qabwxy7effildblswnw7mkrvi 19 40 must must MD work_4qabwxy7effildblswnw7mkrvi 19 41 present present VB work_4qabwxy7effildblswnw7mkrvi 19 42 efficacy efficacy NN work_4qabwxy7effildblswnw7mkrvi 19 43 and and CC work_4qabwxy7effildblswnw7mkrvi 19 44 safety safety NN work_4qabwxy7effildblswnw7mkrvi 19 45 data datum NNS work_4qabwxy7effildblswnw7mkrvi 19 46 to to IN work_4qabwxy7effildblswnw7mkrvi 19 47 the the DT work_4qabwxy7effildblswnw7mkrvi 19 48 Food Food NNP work_4qabwxy7effildblswnw7mkrvi 19 49 and and CC work_4qabwxy7effildblswnw7mkrvi 19 50 Drug Drug NNP work_4qabwxy7effildblswnw7mkrvi 19 51 Administration Administration NNP work_4qabwxy7effildblswnw7mkrvi 19 52 ( ( -LRB- work_4qabwxy7effildblswnw7mkrvi 19 53 FDA FDA NNP work_4qabwxy7effildblswnw7mkrvi 19 54 ) ) -RRB- work_4qabwxy7effildblswnw7mkrvi 19 55 . . . work_4qabwxy7effildblswnw7mkrvi 20 1 If if IN work_4qabwxy7effildblswnw7mkrvi 20 2 sufficient sufficient JJ work_4qabwxy7effildblswnw7mkrvi 20 3 data data NN work_4qabwxy7effildblswnw7mkrvi 20 4 exists exist VBZ work_4qabwxy7effildblswnw7mkrvi 20 5 for for IN work_4qabwxy7effildblswnw7mkrvi 20 6 each each DT work_4qabwxy7effildblswnw7mkrvi 20 7 individual individual JJ work_4qabwxy7effildblswnw7mkrvi 20 8 component component NN work_4qabwxy7effildblswnw7mkrvi 20 9 , , , work_4qabwxy7effildblswnw7mkrvi 20 10 however however RB work_4qabwxy7effildblswnw7mkrvi 20 11 , , , work_4qabwxy7effildblswnw7mkrvi 20 12 drug drug NN work_4qabwxy7effildblswnw7mkrvi 20 13 makers maker NNS work_4qabwxy7effildblswnw7mkrvi 20 14 may may MD work_4qabwxy7effildblswnw7mkrvi 20 15 or or CC work_4qabwxy7effildblswnw7mkrvi 20 16 may may MD work_4qabwxy7effildblswnw7mkrvi 20 17 not not RB work_4qabwxy7effildblswnw7mkrvi 20 18 have have VB work_4qabwxy7effildblswnw7mkrvi 20 19 to to TO work_4qabwxy7effildblswnw7mkrvi 20 20 con- con- VB work_4qabwxy7effildblswnw7mkrvi 20 21 duct duct VB work_4qabwxy7effildblswnw7mkrvi 20 22 additional additional JJ work_4qabwxy7effildblswnw7mkrvi 20 23 studies study NNS work_4qabwxy7effildblswnw7mkrvi 20 24 , , , work_4qabwxy7effildblswnw7mkrvi 20 25 depending depend VBG work_4qabwxy7effildblswnw7mkrvi 20 26 on on IN work_4qabwxy7effildblswnw7mkrvi 20 27 several several JJ work_4qabwxy7effildblswnw7mkrvi 20 28 factors factor NNS work_4qabwxy7effildblswnw7mkrvi 20 29 . . . work_4qabwxy7effildblswnw7mkrvi 21 1 For for IN work_4qabwxy7effildblswnw7mkrvi 21 2 example example NN work_4qabwxy7effildblswnw7mkrvi 21 3 , , , work_4qabwxy7effildblswnw7mkrvi 21 4 new new JJ work_4qabwxy7effildblswnw7mkrvi 21 5 research research NN work_4qabwxy7effildblswnw7mkrvi 21 6 may may MD work_4qabwxy7effildblswnw7mkrvi 21 7 be be VB work_4qabwxy7effildblswnw7mkrvi 21 8 required require VBN work_4qabwxy7effildblswnw7mkrvi 21 9 if if IN work_4qabwxy7effildblswnw7mkrvi 21 10 there there EX work_4qabwxy7effildblswnw7mkrvi 21 11 is be VBZ work_4qabwxy7effildblswnw7mkrvi 21 12 potential potential JJ work_4qabwxy7effildblswnw7mkrvi 21 13 for for IN work_4qabwxy7effildblswnw7mkrvi 21 14 the the DT work_4qabwxy7effildblswnw7mkrvi 21 15 active active JJ work_4qabwxy7effildblswnw7mkrvi 21 16 agents agent NNS work_4qabwxy7effildblswnw7mkrvi 21 17 to to TO work_4qabwxy7effildblswnw7mkrvi 21 18 interact interact VB work_4qabwxy7effildblswnw7mkrvi 21 19 in in IN work_4qabwxy7effildblswnw7mkrvi 21 20 a a DT work_4qabwxy7effildblswnw7mkrvi 21 21 way way NN work_4qabwxy7effildblswnw7mkrvi 21 22 that that WDT work_4qabwxy7effildblswnw7mkrvi 21 23 could could MD work_4qabwxy7effildblswnw7mkrvi 21 24 prove prove VB work_4qabwxy7effildblswnw7mkrvi 21 25 harmful harmful JJ work_4qabwxy7effildblswnw7mkrvi 21 26 , , , work_4qabwxy7effildblswnw7mkrvi 21 27 or or CC work_4qabwxy7effildblswnw7mkrvi 21 28 if if IN work_4qabwxy7effildblswnw7mkrvi 21 29 there there EX work_4qabwxy7effildblswnw7mkrvi 21 30 is be VBZ work_4qabwxy7effildblswnw7mkrvi 21 31 the the DT work_4qabwxy7effildblswnw7mkrvi 21 32 possibility possibility NN work_4qabwxy7effildblswnw7mkrvi 21 33 that that IN work_4qabwxy7effildblswnw7mkrvi 21 34 one one CD work_4qabwxy7effildblswnw7mkrvi 21 35 component component NN work_4qabwxy7effildblswnw7mkrvi 21 36 could could MD work_4qabwxy7effildblswnw7mkrvi 21 37 chemically chemically RB work_4qabwxy7effildblswnw7mkrvi 21 38 modify modify VB work_4qabwxy7effildblswnw7mkrvi 21 39 another another DT work_4qabwxy7effildblswnw7mkrvi 21 40 component component NN work_4qabwxy7effildblswnw7mkrvi 21 41 and and CC work_4qabwxy7effildblswnw7mkrvi 21 42 compromise compromise VB work_4qabwxy7effildblswnw7mkrvi 21 43 its -PRON- PRP$ work_4qabwxy7effildblswnw7mkrvi 21 44 effectiveness effectiveness NN work_4qabwxy7effildblswnw7mkrvi 21 45 . . . work_4qabwxy7effildblswnw7mkrvi 22 1 But but CC work_4qabwxy7effildblswnw7mkrvi 22 2 if if IN work_4qabwxy7effildblswnw7mkrvi 22 3 there there EX work_4qabwxy7effildblswnw7mkrvi 22 4 are be VBP work_4qabwxy7effildblswnw7mkrvi 22 5 no no DT work_4qabwxy7effildblswnw7mkrvi 22 6 apparent apparent JJ work_4qabwxy7effildblswnw7mkrvi 22 7 safety safety NN work_4qabwxy7effildblswnw7mkrvi 22 8 issues issue NNS work_4qabwxy7effildblswnw7mkrvi 22 9 , , , work_4qabwxy7effildblswnw7mkrvi 22 10 the the DT work_4qabwxy7effildblswnw7mkrvi 22 11 manufacturer manufacturer NN work_4qabwxy7effildblswnw7mkrvi 22 12 may may MD work_4qabwxy7effildblswnw7mkrvi 22 13 not not RB work_4qabwxy7effildblswnw7mkrvi 22 14 have have VB work_4qabwxy7effildblswnw7mkrvi 22 15 to to TO work_4qabwxy7effildblswnw7mkrvi 22 16 con- con- VB work_4qabwxy7effildblswnw7mkrvi 22 17 duct duct VB work_4qabwxy7effildblswnw7mkrvi 22 18 any any DT work_4qabwxy7effildblswnw7mkrvi 22 19 additional additional JJ work_4qabwxy7effildblswnw7mkrvi 22 20 research research NN work_4qabwxy7effildblswnw7mkrvi 22 21 . . . work_4qabwxy7effildblswnw7mkrvi 23 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 23 2 If if IN work_4qabwxy7effildblswnw7mkrvi 23 3 existing exist VBG work_4qabwxy7effildblswnw7mkrvi 23 4 clinical clinical JJ work_4qabwxy7effildblswnw7mkrvi 23 5 and and CC work_4qabwxy7effildblswnw7mkrvi 23 6 nonclinical nonclinical JJ work_4qabwxy7effildblswnw7mkrvi 23 7 safety safety NN work_4qabwxy7effildblswnw7mkrvi 23 8 data datum NNS work_4qabwxy7effildblswnw7mkrvi 23 9 for for IN work_4qabwxy7effildblswnw7mkrvi 23 10 each each DT work_4qabwxy7effildblswnw7mkrvi 23 11 separate separate JJ work_4qabwxy7effildblswnw7mkrvi 23 12 drug drug NN work_4qabwxy7effildblswnw7mkrvi 23 13 or or CC work_4qabwxy7effildblswnw7mkrvi 23 14 biologic biologic NN work_4qabwxy7effildblswnw7mkrvi 23 15 are be VBP work_4qabwxy7effildblswnw7mkrvi 23 16 sufficient sufficient JJ work_4qabwxy7effildblswnw7mkrvi 23 17 to to TO work_4qabwxy7effildblswnw7mkrvi 23 18 support support VB work_4qabwxy7effildblswnw7mkrvi 23 19 the the DT work_4qabwxy7effildblswnw7mkrvi 23 20 safety safety NN work_4qabwxy7effildblswnw7mkrvi 23 21 or or CC work_4qabwxy7effildblswnw7mkrvi 23 22 the the DT work_4qabwxy7effildblswnw7mkrvi 23 23 proposed propose VBN work_4qabwxy7effildblswnw7mkrvi 23 24 new new JJ work_4qabwxy7effildblswnw7mkrvi 23 25 indication indication NN work_4qabwxy7effildblswnw7mkrvi 23 26 , , , work_4qabwxy7effildblswnw7mkrvi 23 27 including include VBG work_4qabwxy7effildblswnw7mkrvi 23 28 the the DT work_4qabwxy7effildblswnw7mkrvi 23 29 dose dose NN work_4qabwxy7effildblswnw7mkrvi 23 30 , , , work_4qabwxy7effildblswnw7mkrvi 23 31 dosing dosing NN work_4qabwxy7effildblswnw7mkrvi 23 32 schedule schedule NN work_4qabwxy7effildblswnw7mkrvi 23 33 , , , work_4qabwxy7effildblswnw7mkrvi 23 34 duration duration NN work_4qabwxy7effildblswnw7mkrvi 23 35 , , , work_4qabwxy7effildblswnw7mkrvi 23 36 and and CC work_4qabwxy7effildblswnw7mkrvi 23 37 new new JJ work_4qabwxy7effildblswnw7mkrvi 23 38 patient patient NN work_4qabwxy7effildblswnw7mkrvi 23 39 population population NN work_4qabwxy7effildblswnw7mkrvi 23 40 , , , work_4qabwxy7effildblswnw7mkrvi 23 41 then then RB work_4qabwxy7effildblswnw7mkrvi 23 42 addition addition NN work_4qabwxy7effildblswnw7mkrvi 23 43 nonclinical nonclinical JJ work_4qabwxy7effildblswnw7mkrvi 23 44 studies study NNS work_4qabwxy7effildblswnw7mkrvi 23 45 may may MD work_4qabwxy7effildblswnw7mkrvi 23 46 NewsCMAJ NewsCMAJ NNP work_4qabwxy7effildblswnw7mkrvi 23 47 Reducing reduce VBG work_4qabwxy7effildblswnw7mkrvi 23 48 the the DT work_4qabwxy7effildblswnw7mkrvi 23 49 “ " `` work_4qabwxy7effildblswnw7mkrvi 23 50 pill pill NN work_4qabwxy7effildblswnw7mkrvi 23 51 burden burden NNP work_4qabwxy7effildblswnw7mkrvi 23 52 ” " '' work_4qabwxy7effildblswnw7mkrvi 23 53 © © NNP work_4qabwxy7effildblswnw7mkrvi 23 54 2012 2012 CD work_4qabwxy7effildblswnw7mkrvi 23 55 Canadian Canadian NNP work_4qabwxy7effildblswnw7mkrvi 23 56 Medical Medical NNP work_4qabwxy7effildblswnw7mkrvi 23 57 Association Association NNP work_4qabwxy7effildblswnw7mkrvi 23 58 or or CC work_4qabwxy7effildblswnw7mkrvi 23 59 its -PRON- PRP$ work_4qabwxy7effildblswnw7mkrvi 23 60 licensors licensor NNS work_4qabwxy7effildblswnw7mkrvi 23 61 CMAJ CMAJ NNP work_4qabwxy7effildblswnw7mkrvi 23 62 , , , work_4qabwxy7effildblswnw7mkrvi 23 63 February February NNP work_4qabwxy7effildblswnw7mkrvi 23 64 7 7 CD work_4qabwxy7effildblswnw7mkrvi 23 65 , , , work_4qabwxy7effildblswnw7mkrvi 23 66 2012 2012 CD work_4qabwxy7effildblswnw7mkrvi 23 67 , , , work_4qabwxy7effildblswnw7mkrvi 23 68 184(2 184(2 CD work_4qabwxy7effildblswnw7mkrvi 23 69 ) ) -RRB- work_4qabwxy7effildblswnw7mkrvi 23 70 E117 e117 NN work_4qabwxy7effildblswnw7mkrvi 23 71 Some some DT work_4qabwxy7effildblswnw7mkrvi 23 72 patients patient NNS work_4qabwxy7effildblswnw7mkrvi 23 73 find find VBP work_4qabwxy7effildblswnw7mkrvi 23 74 their -PRON- PRP$ work_4qabwxy7effildblswnw7mkrvi 23 75 pill pill NN work_4qabwxy7effildblswnw7mkrvi 23 76 regimen regiman NNS work_4qabwxy7effildblswnw7mkrvi 23 77 confusing confusing JJ work_4qabwxy7effildblswnw7mkrvi 23 78 . . . work_4qabwxy7effildblswnw7mkrvi 24 1 © © LS work_4qabwxy7effildblswnw7mkrvi 24 2 2 2 CD work_4qabwxy7effildblswnw7mkrvi 24 3 0 0 CD work_4qabwxy7effildblswnw7mkrvi 24 4 1 1 CD work_4qabwxy7effildblswnw7mkrvi 24 5 1 1 CD work_4qabwxy7effildblswnw7mkrvi 24 6 T t NN work_4qabwxy7effildblswnw7mkrvi 24 7 h h NN work_4qabwxy7effildblswnw7mkrvi 24 8 in in IN work_4qabwxy7effildblswnw7mkrvi 24 9 k k NNP work_4qabwxy7effildblswnw7mkrvi 24 10 st st NNP work_4qabwxy7effildblswnw7mkrvi 24 11 o o NNP work_4qabwxy7effildblswnw7mkrvi 24 12 ck ck NNP work_4qabwxy7effildblswnw7mkrvi 24 13 News News NNP work_4qabwxy7effildblswnw7mkrvi 24 14 not not RB work_4qabwxy7effildblswnw7mkrvi 24 15 be be VB work_4qabwxy7effildblswnw7mkrvi 24 16 needed need VBN work_4qabwxy7effildblswnw7mkrvi 24 17 , , , work_4qabwxy7effildblswnw7mkrvi 24 18 ” " '' work_4qabwxy7effildblswnw7mkrvi 24 19 the the DT work_4qabwxy7effildblswnw7mkrvi 24 20 FDA FDA NNP work_4qabwxy7effildblswnw7mkrvi 24 21 states state NNS work_4qabwxy7effildblswnw7mkrvi 24 22 in in IN work_4qabwxy7effildblswnw7mkrvi 24 23 a a DT work_4qabwxy7effildblswnw7mkrvi 24 24 guidance guidance NN work_4qabwxy7effildblswnw7mkrvi 24 25 document document NN work_4qabwxy7effildblswnw7mkrvi 24 26 ( ( -LRB- work_4qabwxy7effildblswnw7mkrvi 24 27 www.fda.gov www.fda.gov NNP work_4qabwxy7effildblswnw7mkrvi 24 28 /downloads /downloads , work_4qabwxy7effildblswnw7mkrvi 24 29 / / SYM work_4qabwxy7effildblswnw7mkrvi 24 30 Drugs Drugs NNP work_4qabwxy7effildblswnw7mkrvi 24 31 / / SYM work_4qabwxy7effildblswnw7mkrvi 24 32 GuidanceCompliance GuidanceCompliance NNP work_4qabwxy7effildblswnw7mkrvi 24 33 RegulatoryInformation RegulatoryInformation NNP work_4qabwxy7effildblswnw7mkrvi 24 34 / / SYM work_4qabwxy7effildblswnw7mkrvi 24 35 Guidances Guidances NNP work_4qabwxy7effildblswnw7mkrvi 24 36 / / SYM work_4qabwxy7effildblswnw7mkrvi 24 37 ucm ucm NNP work_4qabwxy7effildblswnw7mkrvi 24 38 079243.pdf 079243.pdf CD work_4qabwxy7effildblswnw7mkrvi 24 39 ) ) -RRB- work_4qabwxy7effildblswnw7mkrvi 24 40 . . . work_4qabwxy7effildblswnw7mkrvi 25 1 In in IN work_4qabwxy7effildblswnw7mkrvi 25 2 some some DT work_4qabwxy7effildblswnw7mkrvi 25 3 situations situation NNS work_4qabwxy7effildblswnw7mkrvi 25 4 , , , work_4qabwxy7effildblswnw7mkrvi 25 5 FDA FDA NNP work_4qabwxy7effildblswnw7mkrvi 25 6 may may MD work_4qabwxy7effildblswnw7mkrvi 25 7 even even RB work_4qabwxy7effildblswnw7mkrvi 25 8 accelerate accelerate VB work_4qabwxy7effildblswnw7mkrvi 25 9 the the DT work_4qabwxy7effildblswnw7mkrvi 25 10 approval approval NN work_4qabwxy7effildblswnw7mkrvi 25 11 process process NN work_4qabwxy7effildblswnw7mkrvi 25 12 if if IN work_4qabwxy7effildblswnw7mkrvi 25 13 suffi- suffi- NNP work_4qabwxy7effildblswnw7mkrvi 25 14 cient cient NNP work_4qabwxy7effildblswnw7mkrvi 25 15 data data NNP work_4qabwxy7effildblswnw7mkrvi 25 16 exists exist VBZ work_4qabwxy7effildblswnw7mkrvi 25 17 for for IN work_4qabwxy7effildblswnw7mkrvi 25 18 the the DT work_4qabwxy7effildblswnw7mkrvi 25 19 component component NN work_4qabwxy7effildblswnw7mkrvi 25 20 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 25 21 . . . work_4qabwxy7effildblswnw7mkrvi 26 1 This this DT work_4qabwxy7effildblswnw7mkrvi 26 2 appears appear VBZ work_4qabwxy7effildblswnw7mkrvi 26 3 to to TO work_4qabwxy7effildblswnw7mkrvi 26 4 be be VB work_4qabwxy7effildblswnw7mkrvi 26 5 the the DT work_4qabwxy7effildblswnw7mkrvi 26 6 case case NN work_4qabwxy7effildblswnw7mkrvi 26 7 , , , work_4qabwxy7effildblswnw7mkrvi 26 8 for for IN work_4qabwxy7effildblswnw7mkrvi 26 9 instance instance NN work_4qabwxy7effildblswnw7mkrvi 26 10 , , , work_4qabwxy7effildblswnw7mkrvi 26 11 for for IN work_4qabwxy7effildblswnw7mkrvi 26 12 fixed fix VBN work_4qabwxy7effildblswnw7mkrvi 26 13 - - HYPH work_4qabwxy7effildblswnw7mkrvi 26 14 dose dose VBN work_4qabwxy7effildblswnw7mkrvi 26 15 combinations combination NNS work_4qabwxy7effildblswnw7mkrvi 26 16 or or CC work_4qabwxy7effildblswnw7mkrvi 26 17 copackaged copackage VBN work_4qabwxy7effildblswnw7mkrvi 26 18 drug drug NN work_4qabwxy7effildblswnw7mkrvi 26 19 products product NNS work_4qabwxy7effildblswnw7mkrvi 26 20 made make VBN work_4qabwxy7effildblswnw7mkrvi 26 21 from from IN work_4qabwxy7effildblswnw7mkrvi 26 22 previously previously RB work_4qabwxy7effildblswnw7mkrvi 26 23 approved approve VBN work_4qabwxy7effildblswnw7mkrvi 26 24 antiretrovi- antiretrovi- NNP work_4qabwxy7effildblswnw7mkrvi 26 25 rals ral NNS work_4qabwxy7effildblswnw7mkrvi 26 26 to to TO work_4qabwxy7effildblswnw7mkrvi 26 27 treat treat VB work_4qabwxy7effildblswnw7mkrvi 26 28 HIV HIV NNP work_4qabwxy7effildblswnw7mkrvi 26 29 . . . work_4qabwxy7effildblswnw7mkrvi 27 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 27 2 FDA FDA NNP work_4qabwxy7effildblswnw7mkrvi 27 3 believes believe VBZ work_4qabwxy7effildblswnw7mkrvi 27 4 that that IN work_4qabwxy7effildblswnw7mkrvi 27 5 when when WRB work_4qabwxy7effildblswnw7mkrvi 27 6 adequate adequate JJ work_4qabwxy7effildblswnw7mkrvi 27 7 evidence evidence NN work_4qabwxy7effildblswnw7mkrvi 27 8 of of IN work_4qabwxy7effildblswnw7mkrvi 27 9 safety safety NN work_4qabwxy7effildblswnw7mkrvi 27 10 and and CC work_4qabwxy7effildblswnw7mkrvi 27 11 efficacy efficacy NN work_4qabwxy7effildblswnw7mkrvi 27 12 exists exist VBZ work_4qabwxy7effildblswnw7mkrvi 27 13 for for IN work_4qabwxy7effildblswnw7mkrvi 27 14 the the DT work_4qabwxy7effildblswnw7mkrvi 27 15 use use NN work_4qabwxy7effildblswnw7mkrvi 27 16 of of IN work_4qabwxy7effildblswnw7mkrvi 27 17 combination combination NN work_4qabwxy7effildblswnw7mkrvi 27 18 therapy therapy NN work_4qabwxy7effildblswnw7mkrvi 27 19 with with IN work_4qabwxy7effildblswnw7mkrvi 27 20 individually individually RB work_4qabwxy7effildblswnw7mkrvi 27 21 approved approve VBN work_4qabwxy7effildblswnw7mkrvi 27 22 HIV HIV NNP work_4qabwxy7effildblswnw7mkrvi 27 23 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 27 24 , , , work_4qabwxy7effildblswnw7mkrvi 27 25 the the DT work_4qabwxy7effildblswnw7mkrvi 27 26 path path NN work_4qabwxy7effildblswnw7mkrvi 27 27 to to IN work_4qabwxy7effildblswnw7mkrvi 27 28 regulatory regulatory JJ work_4qabwxy7effildblswnw7mkrvi 27 29 approval approval NN work_4qabwxy7effildblswnw7mkrvi 27 30 of of IN work_4qabwxy7effildblswnw7mkrvi 27 31 an an DT work_4qabwxy7effildblswnw7mkrvi 27 32 FDC FDC NNP work_4qabwxy7effildblswnw7mkrvi 27 33 [ [ -LRB- work_4qabwxy7effildblswnw7mkrvi 27 34 fixed fix VBN work_4qabwxy7effildblswnw7mkrvi 27 35 - - HYPH work_4qabwxy7effildblswnw7mkrvi 27 36 dose dose NN work_4qabwxy7effildblswnw7mkrvi 27 37 combination combination NN work_4qabwxy7effildblswnw7mkrvi 27 38 ] ] -RRB- work_4qabwxy7effildblswnw7mkrvi 27 39 or or CC work_4qabwxy7effildblswnw7mkrvi 27 40 co- co- VBN work_4qabwxy7effildblswnw7mkrvi 27 41 packaged package VBN work_4qabwxy7effildblswnw7mkrvi 27 42 configuration configuration NN work_4qabwxy7effildblswnw7mkrvi 27 43 of of IN work_4qabwxy7effildblswnw7mkrvi 27 44 those those DT work_4qabwxy7effildblswnw7mkrvi 27 45 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 27 46 is be VBZ work_4qabwxy7effildblswnw7mkrvi 27 47 straightforward straightforward JJ work_4qabwxy7effildblswnw7mkrvi 27 48 , , , work_4qabwxy7effildblswnw7mkrvi 27 49 ” " '' work_4qabwxy7effildblswnw7mkrvi 27 50 the the DT work_4qabwxy7effildblswnw7mkrvi 27 51 agency agency NN work_4qabwxy7effildblswnw7mkrvi 27 52 states state VBZ work_4qabwxy7effildblswnw7mkrvi 27 53 in in IN work_4qabwxy7effildblswnw7mkrvi 27 54 another another DT work_4qabwxy7effildblswnw7mkrvi 27 55 guidance guidance NN work_4qabwxy7effildblswnw7mkrvi 27 56 document document NN work_4qabwxy7effildblswnw7mkrvi 27 57 ( ( -LRB- work_4qabwxy7effildblswnw7mkrvi 27 58 www www NN work_4qabwxy7effildblswnw7mkrvi 27 59 .fda .fda CD work_4qabwxy7effildblswnw7mkrvi 27 60 .gov .gov . work_4qabwxy7effildblswnw7mkrvi 27 61 / / SYM work_4qabwxy7effildblswnw7mkrvi 27 62 downloads download NNS work_4qabwxy7effildblswnw7mkrvi 27 63 / / SYM work_4qabwxy7effildblswnw7mkrvi 27 64 Drugs Drugs NNPS work_4qabwxy7effildblswnw7mkrvi 27 65 / / SYM work_4qabwxy7effildblswnw7mkrvi 27 66 Guidance Guidance NNP work_4qabwxy7effildblswnw7mkrvi 27 67 ComplianceRegulatoryInformation complianceregulatoryinformation NN work_4qabwxy7effildblswnw7mkrvi 27 68 /Guidances /guidance NNS work_4qabwxy7effildblswnw7mkrvi 27 69 / / SYM work_4qabwxy7effildblswnw7mkrvi 27 70 UCM079742.pdf ucm079742.pdf NN work_4qabwxy7effildblswnw7mkrvi 27 71 ) ) -RRB- work_4qabwxy7effildblswnw7mkrvi 27 72 . . . work_4qabwxy7effildblswnw7mkrvi 28 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 28 2 FDA FDA NNP work_4qabwxy7effildblswnw7mkrvi 28 3 is be VBZ work_4qabwxy7effildblswnw7mkrvi 28 4 prepared prepared JJ work_4qabwxy7effildblswnw7mkrvi 28 5 to to TO work_4qabwxy7effildblswnw7mkrvi 28 6 move move VB work_4qabwxy7effildblswnw7mkrvi 28 7 swiftly swiftly RB work_4qabwxy7effildblswnw7mkrvi 28 8 to to TO work_4qabwxy7effildblswnw7mkrvi 28 9 evaluate evaluate VB work_4qabwxy7effildblswnw7mkrvi 28 10 such such JJ work_4qabwxy7effildblswnw7mkrvi 28 11 products product NNS work_4qabwxy7effildblswnw7mkrvi 28 12 when when WRB work_4qabwxy7effildblswnw7mkrvi 28 13 applications application NNS work_4qabwxy7effildblswnw7mkrvi 28 14 are be VBP work_4qabwxy7effildblswnw7mkrvi 28 15 submitted submit VBN work_4qabwxy7effildblswnw7mkrvi 28 16 for for IN work_4qabwxy7effildblswnw7mkrvi 28 17 approval approval NN work_4qabwxy7effildblswnw7mkrvi 28 18 . . . work_4qabwxy7effildblswnw7mkrvi 28 19 ” " '' work_4qabwxy7effildblswnw7mkrvi 28 20 This this DT work_4qabwxy7effildblswnw7mkrvi 28 21 is be VBZ work_4qabwxy7effildblswnw7mkrvi 28 22 good good JJ work_4qabwxy7effildblswnw7mkrvi 28 23 news news NN work_4qabwxy7effildblswnw7mkrvi 28 24 for for IN work_4qabwxy7effildblswnw7mkrvi 28 25 people people NNS work_4qabwxy7effildblswnw7mkrvi 28 26 with with IN work_4qabwxy7effildblswnw7mkrvi 28 27 certain certain JJ work_4qabwxy7effildblswnw7mkrvi 28 28 conditions condition NNS work_4qabwxy7effildblswnw7mkrvi 28 29 , , , work_4qabwxy7effildblswnw7mkrvi 28 30 such such JJ work_4qabwxy7effildblswnw7mkrvi 28 31 as as IN work_4qabwxy7effildblswnw7mkrvi 28 32 glaucoma glaucoma NN work_4qabwxy7effildblswnw7mkrvi 28 33 , , , work_4qabwxy7effildblswnw7mkrvi 28 34 who who WP work_4qabwxy7effildblswnw7mkrvi 28 35 have have VBP work_4qabwxy7effildblswnw7mkrvi 28 36 been be VBN work_4qabwxy7effildblswnw7mkrvi 28 37 shown show VBN work_4qabwxy7effildblswnw7mkrvi 28 38 to to IN work_4qabwxy7effildblswnw7mkrvi 28 39 not not RB work_4qabwxy7effildblswnw7mkrvi 28 40 only only RB work_4qabwxy7effildblswnw7mkrvi 28 41 better well RBR work_4qabwxy7effildblswnw7mkrvi 28 42 comply comply VB work_4qabwxy7effildblswnw7mkrvi 28 43 with with IN work_4qabwxy7effildblswnw7mkrvi 28 44 fixed fix VBN work_4qabwxy7effildblswnw7mkrvi 28 45 - - HYPH work_4qabwxy7effildblswnw7mkrvi 28 46 dose dose NN work_4qabwxy7effildblswnw7mkrvi 28 47 combination combination NN work_4qabwxy7effildblswnw7mkrvi 28 48 drug drug NN work_4qabwxy7effildblswnw7mkrvi 28 49 regimens regimen VBZ work_4qabwxy7effildblswnw7mkrvi 28 50 but but CC work_4qabwxy7effildblswnw7mkrvi 28 51 also also RB work_4qabwxy7effildblswnw7mkrvi 28 52 to to TO work_4qabwxy7effildblswnw7mkrvi 28 53 save save VB work_4qabwxy7effildblswnw7mkrvi 28 54 money money NN work_4qabwxy7effildblswnw7mkrvi 28 55 while while IN work_4qabwxy7effildblswnw7mkrvi 28 56 reducing reduce VBG work_4qabwxy7effildblswnw7mkrvi 28 57 their -PRON- PRP$ work_4qabwxy7effildblswnw7mkrvi 28 58 pill pill NN work_4qabwxy7effildblswnw7mkrvi 28 59 burden burden NN work_4qabwxy7effildblswnw7mkrvi 28 60 , , , work_4qabwxy7effildblswnw7mkrvi 28 61 according accord VBG work_4qabwxy7effildblswnw7mkrvi 28 62 to to IN work_4qabwxy7effildblswnw7mkrvi 28 63 the the DT work_4qabwxy7effildblswnw7mkrvi 28 64 American American NNP work_4qabwxy7effildblswnw7mkrvi 28 65 Academy Academy NNP work_4qabwxy7effildblswnw7mkrvi 28 66 of of IN work_4qabwxy7effildblswnw7mkrvi 28 67 Ophthalmology Ophthalmology NNP work_4qabwxy7effildblswnw7mkrvi 28 68 ( ( -LRB- work_4qabwxy7effildblswnw7mkrvi 28 69 www.oculist.net www.oculist.net NNP work_4qabwxy7effildblswnw7mkrvi 28 70 /Soft /Soft NFP work_4qabwxy7effildblswnw7mkrvi 28 71 /ShowSoftDown.asp?UrlID=1&SoftID /ShowSoftDown.asp?UrlID=1&SoftID . work_4qabwxy7effildblswnw7mkrvi 28 72 = = SYM work_4qabwxy7effildblswnw7mkrvi 28 73 377#page=162 377#page=162 CD work_4qabwxy7effildblswnw7mkrvi 28 74 ) ) -RRB- work_4qabwxy7effildblswnw7mkrvi 28 75 . . . work_4qabwxy7effildblswnw7mkrvi 29 1 Those those DT work_4qabwxy7effildblswnw7mkrvi 29 2 benefits benefit NNS work_4qabwxy7effildblswnw7mkrvi 29 3 , , , work_4qabwxy7effildblswnw7mkrvi 29 4 though though RB work_4qabwxy7effildblswnw7mkrvi 29 5 , , , work_4qabwxy7effildblswnw7mkrvi 29 6 may may MD work_4qabwxy7effildblswnw7mkrvi 29 7 come come VB work_4qabwxy7effildblswnw7mkrvi 29 8 at at IN work_4qabwxy7effildblswnw7mkrvi 29 9 a a DT work_4qabwxy7effildblswnw7mkrvi 29 10 cost cost NN work_4qabwxy7effildblswnw7mkrvi 29 11 . . . work_4qabwxy7effildblswnw7mkrvi 30 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 30 2 In in IN work_4qabwxy7effildblswnw7mkrvi 30 3 an an DT work_4qabwxy7effildblswnw7mkrvi 30 4 era era NN work_4qabwxy7effildblswnw7mkrvi 30 5 of of IN work_4qabwxy7effildblswnw7mkrvi 30 6 many many JJ work_4qabwxy7effildblswnw7mkrvi 30 7 drug drug NN work_4qabwxy7effildblswnw7mkrvi 30 8 choices choice NNS work_4qabwxy7effildblswnw7mkrvi 30 9 and and CC work_4qabwxy7effildblswnw7mkrvi 30 10 the the DT work_4qabwxy7effildblswnw7mkrvi 30 11 ability ability NN work_4qabwxy7effildblswnw7mkrvi 30 12 to to TO work_4qabwxy7effildblswnw7mkrvi 30 13 individualize individualize VB work_4qabwxy7effildblswnw7mkrvi 30 14 patient patient NN work_4qabwxy7effildblswnw7mkrvi 30 15 care care NN work_4qabwxy7effildblswnw7mkrvi 30 16 as as IN work_4qabwxy7effildblswnw7mkrvi 30 17 never never RB work_4qabwxy7effildblswnw7mkrvi 30 18 before before RB work_4qabwxy7effildblswnw7mkrvi 30 19 , , , work_4qabwxy7effildblswnw7mkrvi 30 20 the the DT work_4qabwxy7effildblswnw7mkrvi 30 21 fixed fix VBN work_4qabwxy7effildblswnw7mkrvi 30 22 combinations combination NNS work_4qabwxy7effildblswnw7mkrvi 30 23 limit limit VBP work_4qabwxy7effildblswnw7mkrvi 30 24 clinicians clinician NNS work_4qabwxy7effildblswnw7mkrvi 30 25 ’ ’ POS work_4qabwxy7effildblswnw7mkrvi 30 26 ability ability NN work_4qabwxy7effildblswnw7mkrvi 30 27 to to TO work_4qabwxy7effildblswnw7mkrvi 30 28 customize customize VB work_4qabwxy7effildblswnw7mkrvi 30 29 dosing dosing NN work_4qabwxy7effildblswnw7mkrvi 30 30 regimens regimen NNS work_4qabwxy7effildblswnw7mkrvi 30 31 , , , work_4qabwxy7effildblswnw7mkrvi 30 32 ” " '' work_4qabwxy7effildblswnw7mkrvi 30 33 the the DT work_4qabwxy7effildblswnw7mkrvi 30 34 document document NN work_4qabwxy7effildblswnw7mkrvi 30 35 states state NNS work_4qabwxy7effildblswnw7mkrvi 30 36 . . . work_4qabwxy7effildblswnw7mkrvi 31 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 31 2 Unless unless IN work_4qabwxy7effildblswnw7mkrvi 31 3 prescribed prescribe VBN work_4qabwxy7effildblswnw7mkrvi 31 4 with with IN work_4qabwxy7effildblswnw7mkrvi 31 5 caution caution NN work_4qabwxy7effildblswnw7mkrvi 31 6 , , , work_4qabwxy7effildblswnw7mkrvi 31 7 fixed- fixed- JJ work_4qabwxy7effildblswnw7mkrvi 31 8 combination combination NN work_4qabwxy7effildblswnw7mkrvi 31 9 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 31 10 may may MD work_4qabwxy7effildblswnw7mkrvi 31 11 result result VB work_4qabwxy7effildblswnw7mkrvi 31 12 in in IN work_4qabwxy7effildblswnw7mkrvi 31 13 overtreatment overtreatment NN work_4qabwxy7effildblswnw7mkrvi 31 14 for for IN work_4qabwxy7effildblswnw7mkrvi 31 15 patients patient NNS work_4qabwxy7effildblswnw7mkrvi 31 16 who who WP work_4qabwxy7effildblswnw7mkrvi 31 17 may may MD work_4qabwxy7effildblswnw7mkrvi 31 18 be be VB work_4qabwxy7effildblswnw7mkrvi 31 19 controlled control VBN work_4qabwxy7effildblswnw7mkrvi 31 20 with with IN work_4qabwxy7effildblswnw7mkrvi 31 21 a a DT work_4qabwxy7effildblswnw7mkrvi 31 22 single single JJ work_4qabwxy7effildblswnw7mkrvi 31 23 agent agent NN work_4qabwxy7effildblswnw7mkrvi 31 24 or or CC work_4qabwxy7effildblswnw7mkrvi 31 25 fewer few JJR work_4qabwxy7effildblswnw7mkrvi 31 26 doses dose NNS work_4qabwxy7effildblswnw7mkrvi 31 27 of of IN work_4qabwxy7effildblswnw7mkrvi 31 28 combined combine VBN work_4qabwxy7effildblswnw7mkrvi 31 29 medications medication NNS work_4qabwxy7effildblswnw7mkrvi 31 30 if if IN work_4qabwxy7effildblswnw7mkrvi 31 31 dosed dose VBN work_4qabwxy7effildblswnw7mkrvi 31 32 concomitantly concomitantly RB work_4qabwxy7effildblswnw7mkrvi 31 33 . . . work_4qabwxy7effildblswnw7mkrvi 31 34 ” " '' work_4qabwxy7effildblswnw7mkrvi 31 35 Still still RB work_4qabwxy7effildblswnw7mkrvi 31 36 , , , work_4qabwxy7effildblswnw7mkrvi 31 37 the the DT work_4qabwxy7effildblswnw7mkrvi 31 38 primary primary JJ work_4qabwxy7effildblswnw7mkrvi 31 39 benefit benefit NN work_4qabwxy7effildblswnw7mkrvi 31 40 of of IN work_4qabwxy7effildblswnw7mkrvi 31 41 combina- combina- NNP work_4qabwxy7effildblswnw7mkrvi 31 42 tion tion NN work_4qabwxy7effildblswnw7mkrvi 31 43 drugs drug NNS work_4qabwxy7effildblswnw7mkrvi 31 44 — — : work_4qabwxy7effildblswnw7mkrvi 31 45 a a DT work_4qabwxy7effildblswnw7mkrvi 31 46 substantial substantial JJ work_4qabwxy7effildblswnw7mkrvi 31 47 increase increase NN work_4qabwxy7effildblswnw7mkrvi 31 48 adherence adherence NN work_4qabwxy7effildblswnw7mkrvi 31 49 to to IN work_4qabwxy7effildblswnw7mkrvi 31 50 treatment treatment NN work_4qabwxy7effildblswnw7mkrvi 31 51 — — : work_4qabwxy7effildblswnw7mkrvi 31 52 may may MD work_4qabwxy7effildblswnw7mkrvi 31 53 out- out- RB work_4qabwxy7effildblswnw7mkrvi 31 54 weigh weigh VB work_4qabwxy7effildblswnw7mkrvi 31 55 the the DT work_4qabwxy7effildblswnw7mkrvi 31 56 potential potential JJ work_4qabwxy7effildblswnw7mkrvi 31 57 problems problem NNS work_4qabwxy7effildblswnw7mkrvi 31 58 as as IN work_4qabwxy7effildblswnw7mkrvi 31 59 aging age VBG work_4qabwxy7effildblswnw7mkrvi 31 60 populations population NNS work_4qabwxy7effildblswnw7mkrvi 31 61 require require VBP work_4qabwxy7effildblswnw7mkrvi 31 62 more more JJR work_4qabwxy7effildblswnw7mkrvi 31 63 medications medication NNS work_4qabwxy7effildblswnw7mkrvi 31 64 to to TO work_4qabwxy7effildblswnw7mkrvi 31 65 control control VB work_4qabwxy7effildblswnw7mkrvi 31 66 chronic chronic JJ work_4qabwxy7effildblswnw7mkrvi 31 67 illnesses illness NNS work_4qabwxy7effildblswnw7mkrvi 31 68 , , , work_4qabwxy7effildblswnw7mkrvi 31 69 says say VBZ work_4qabwxy7effildblswnw7mkrvi 31 70 Fendrick Fendrick NNP work_4qabwxy7effildblswnw7mkrvi 31 71 . . . work_4qabwxy7effildblswnw7mkrvi 32 1 “ " `` work_4qabwxy7effildblswnw7mkrvi 32 2 As as IN work_4qabwxy7effildblswnw7mkrvi 32 3 we -PRON- PRP work_4qabwxy7effildblswnw7mkrvi 32 4 realize realize VBP work_4qabwxy7effildblswnw7mkrvi 32 5 that that IN work_4qabwxy7effildblswnw7mkrvi 32 6 many many JJ work_4qabwxy7effildblswnw7mkrvi 32 7 chronic chronic JJ work_4qabwxy7effildblswnw7mkrvi 32 8 dis- dis- IN work_4qabwxy7effildblswnw7mkrvi 32 9 eases ease NNS work_4qabwxy7effildblswnw7mkrvi 32 10 will will MD work_4qabwxy7effildblswnw7mkrvi 32 11 require require VB work_4qabwxy7effildblswnw7mkrvi 32 12 more more JJR work_4qabwxy7effildblswnw7mkrvi 32 13 than than IN work_4qabwxy7effildblswnw7mkrvi 32 14 one one CD work_4qabwxy7effildblswnw7mkrvi 32 15 agent agent NN work_4qabwxy7effildblswnw7mkrvi 32 16 to to TO work_4qabwxy7effildblswnw7mkrvi 32 17 appropriately appropriately RB work_4qabwxy7effildblswnw7mkrvi 32 18 manage manage VB work_4qabwxy7effildblswnw7mkrvi 32 19 conditions condition NNS work_4qabwxy7effildblswnw7mkrvi 32 20 such such JJ work_4qabwxy7effildblswnw7mkrvi 32 21 as as IN work_4qabwxy7effildblswnw7mkrvi 32 22 hypertension hypertension NN work_4qabwxy7effildblswnw7mkrvi 32 23 and and CC work_4qabwxy7effildblswnw7mkrvi 32 24 diabetes diabetes NN work_4qabwxy7effildblswnw7mkrvi 32 25 and and CC work_4qabwxy7effildblswnw7mkrvi 32 26 asthma asthma NN work_4qabwxy7effildblswnw7mkrvi 32 27 and and CC work_4qabwxy7effildblswnw7mkrvi 32 28 emphysema emphysema NNP work_4qabwxy7effildblswnw7mkrvi 32 29 , , , work_4qabwxy7effildblswnw7mkrvi 32 30 it -PRON- PRP work_4qabwxy7effildblswnw7mkrvi 32 31 would would MD work_4qabwxy7effildblswnw7mkrvi 32 32 n’t not RB work_4qabwxy7effildblswnw7mkrvi 32 33 surprise surprise VB work_4qabwxy7effildblswnw7mkrvi 32 34 me -PRON- PRP work_4qabwxy7effildblswnw7mkrvi 32 35 at at RB work_4qabwxy7effildblswnw7mkrvi 32 36 all all RB work_4qabwxy7effildblswnw7mkrvi 32 37 to to TO work_4qabwxy7effildblswnw7mkrvi 32 38 see see VB work_4qabwxy7effildblswnw7mkrvi 32 39 additional additional JJ work_4qabwxy7effildblswnw7mkrvi 32 40 and and CC work_4qabwxy7effildblswnw7mkrvi 32 41 perhaps perhaps RB work_4qabwxy7effildblswnw7mkrvi 32 42 more more RBR work_4qabwxy7effildblswnw7mkrvi 32 43 sophisticated sophisticated JJ work_4qabwxy7effildblswnw7mkrvi 32 44 combination combination NN work_4qabwxy7effildblswnw7mkrvi 32 45 therapies therapy NNS work_4qabwxy7effildblswnw7mkrvi 32 46 to to TO work_4qabwxy7effildblswnw7mkrvi 32 47 help help VB work_4qabwxy7effildblswnw7mkrvi 32 48 patients patient NNS work_4qabwxy7effildblswnw7mkrvi 32 49 comply comply VB work_4qabwxy7effildblswnw7mkrvi 32 50 with with IN work_4qabwxy7effildblswnw7mkrvi 32 51 increasingly increasingly RB work_4qabwxy7effildblswnw7mkrvi 32 52 complex complex JJ work_4qabwxy7effildblswnw7mkrvi 32 53 drug drug NN work_4qabwxy7effildblswnw7mkrvi 32 54 regimens regimen VBZ work_4qabwxy7effildblswnw7mkrvi 32 55 . . . work_4qabwxy7effildblswnw7mkrvi 32 56 ” " '' work_4qabwxy7effildblswnw7mkrvi 32 57 — — : work_4qabwxy7effildblswnw7mkrvi 32 58 Roger Roger NNP work_4qabwxy7effildblswnw7mkrvi 32 59 Collier Collier NNP work_4qabwxy7effildblswnw7mkrvi 32 60 , , , work_4qabwxy7effildblswnw7mkrvi 32 61 CMAJ CMAJ NNP work_4qabwxy7effildblswnw7mkrvi 32 62 CMAJ CMAJ NNP work_4qabwxy7effildblswnw7mkrvi 32 63 2011 2011 CD work_4qabwxy7effildblswnw7mkrvi 32 64 . . . work_4qabwxy7effildblswnw7mkrvi 33 1 DOI:10.1503 DOI:10.1503 NNP work_4qabwxy7effildblswnw7mkrvi 33 2 / / SYM work_4qabwxy7effildblswnw7mkrvi 33 3 cmaj.109 cmaj.109 NNP work_4qabwxy7effildblswnw7mkrvi 33 4 - - HYPH work_4qabwxy7effildblswnw7mkrvi 33 5 4076 4076 CD work_4qabwxy7effildblswnw7mkrvi 33 6 E118 E118 NNP work_4qabwxy7effildblswnw7mkrvi 33 7 CMAJ CMAJ NNP work_4qabwxy7effildblswnw7mkrvi 33 8 , , , work_4qabwxy7effildblswnw7mkrvi 33 9 February February NNP work_4qabwxy7effildblswnw7mkrvi 33 10 7 7 CD work_4qabwxy7effildblswnw7mkrvi 33 11 , , , work_4qabwxy7effildblswnw7mkrvi 33 12 2012 2012 CD work_4qabwxy7effildblswnw7mkrvi 33 13 , , , work_4qabwxy7effildblswnw7mkrvi 33 14 184(2 184(2 CD work_4qabwxy7effildblswnw7mkrvi 33 15 ) ) -RRB-