id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_mdc7fza2xbbzzlqz2tcbd7ghi4	Krishna K. Sarangapani	Catch and release: how do kinetochores hook the right microtubules during mitosis?	2014.0	10	.pdf	application/pdf	9025	1221	42	angler's trick, operating at kinetochores, ensures accuracy during mitosis: the mitotic spindle attaches randomly to chromosomes and then correctly bioriented the idea that mechanical tension signals proper attachment of chromosomes to microtubules of the mitotic spindle and selectively stabilizes these attachments. at the inner centromere) selectively phosphorylates the kinetochores of relaxed chromosomes, weakening their grip on the microtubules and promoting their release. Tension on correctly bioriented chromosomes causes them to stretch, spatially separating their kinetochores from Aurora B and preventing kinase-triggered detachment. Immunostaining with the '3F3' antibody confirms that tension, either from a micromanipulation needle or from normal spindle forces, can inhibit kinetochore phosphorylation lifetime versus force relations for both kinetochore-microtubule attachments and canonical catch bond systems are between tension, microtubule tip dynamics, and kinetochore attachment stability in interesting ways. two concepts: that Aurora B phosphorylation causes kinetochore detachment from the spindle, and that tension suppresses this activity, possibly by spatially separating Tension-dependent stabilization of kinetochore-microtubule attachments	./cache/work_mdc7fza2xbbzzlqz2tcbd7ghi4.pdf	./txt/work_mdc7fza2xbbzzlqz2tcbd7ghi4.txt