id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
work_ohwtalvymjgqbo4dw3lfg7mokm	Tony Hunter	Signaling—2000 and Beyond	2000.0	15	.pdf	application/pdf	14103	989	51	Receptor protein-serine kinases are realization that most protein–protein interaction doalso activated by ligand-induced dimerization. naling downstream of activated receptor PTKs. SH2 dothat domains involved in membrane signaling can recogmains bind in a sequence-specific fashion, recognizing A prime example is the receptor PTK-Rasnucleus, and there phosphorylate and activate transcription factors.MAP kinase pathway, where genetic and biochemical quires such short sequences combined with the funcgreatly increases the affinity of these proteins as subtional independence of these domains presumably strates for phosphorylation by activated receptor PTKs. facilitated the rapid genesis of new protein–protein A dramatic illustration of the importance of protein proxinteractions during evolution. is well established that ligand-induced dimerization is"anti-phosphatases", which are proteins structurally rerequired for activation of receptor PTKs, recent evi-lated to the PTP or dual-specificity phosphatase famidence suggests that dimerization per se may not belies, but which lack one or more of the residues essential Structural analysis of signaling proteins has already promises to accelerate the pace of development of specific small molecule or peptide-based inhibitors (Mo-revealed new and unexpected principles of regulation.	./cache/work_ohwtalvymjgqbo4dw3lfg7mokm.pdf	./txt/work_ohwtalvymjgqbo4dw3lfg7mokm.txt