0 JAMES EPPS, UOMMOOPITHIC CHEMIST, 170, Piccadilly Next the Egyptian h all; 112, Great Russell Street, Close to Tottenham Court Road | 82, Old Broad Street, City, A few doors from tho Bank. Established 1839. m yiQ 2I INTRODUCTION. SOME apology is due to the learned author and the public for the mutilation of a work valuable in all its parts. All the parts, however, were not necessary for my purpose, and would have needlessly increased the expences of publication and the price of the work. My object is to recommend to the English student a scientific study of the Materia Medica, and to put before him the mode in which Hirschel thinks it may be carried out, as well as to present scientific criteria for the ascertainment of pathological resemblances. I must own that I see much greater difficulties in the way of the scientific investigation of the characters of a medicine than I did at first sight. These difficulties, it appears to me, arise from the imperfect state of our pathological knowledge. We cannot, I think at present, mount up, as Hirschel has endeavoured to do with Bryony and Rhus, to that element in the action of a medicine, out of which all the others proceed. With many medicines indeed we hardly know where to begin or where to end. An intricate nexus of actions lies before us, nothing points to a centre, we must be content to record, we cannot analyze, This is especially true of those medicines which act on the vegetative life, such as Sulphur, Calcarea, Lycopodium, &c. Opposite actions fail us here, or at least cease to characterize the general action. Nor is this wonderful. We have come to the region of harmoB INTRODUCTION. nious, yet to some extent independent, sources of action. The ganglionic system has its various nuclei of action; it is a system of confederated powers, and we must expect to find greater complexity than prevails in an autocracy. The attempt indeed to find a primitive action out of which all the others are deducible, may turn out to be like the attempt to find out the commencement of a circle. Independently of these considerations, physiology at her present period of development cannot explain all the phenomena that occur to us, indeed cannot always enable us to refer them to their proper seat. Hirschel endeavours, as far as is possible, to do this for us. In the following passage he says:* " the modality of the pain appears to depend partly on the affected part, partly on the morbid process. " Burning pain occurs, especially in the skin and mucous membrane, the boring gnawing pain in the bones, the drawinc: in the nerves and muscles, the constrictive in the canals, thlat as of sprain in the joints, that of shooting and cutting in the serous and fibrous membranes. The various modifications of pain are sub-species of certain principal groups. Then as regards the morbid process, drawing tearing pains are occasioned by rheumatism, (Rhus,) jerking by affections of the nerves of motion, (Amm. c. Stann.,) throbbing, beating, hammering, by movements of the vascular walls; hyperasmia in the capillaries, congestions, (Aconite, Bellad.,) shooting by the more partial local accumulations of blood in the parenchyma, in the venous and capillary system, (Puls.,) the burning pains are consequences of passive stases, or incipient decomposition (Phosph., Carb., Arsen.). The aching and shooting pains of Bryony correspond to impending exudation; the jerking, tearing, and throbbing pains of Chamomilla with peculiar restlessness, to reflex action from the nerves of sensation on the circulation; the pain of excoriation in Ilepar is connected with the formation of abscess. "The accompanying, preceding, or following pains have SCrundriss ler Hoimopathie, S. 167-170. ( 2nd Ed.). INTRODUCTION. 3 also their own significance. In affections of the prostate the pain follows micturition; in the affections of the mucous membrane of the urethra it precedes and accompanies it. In gastric affections it is not a matter of indifference at what period of the digestion a pain occurs. Constant- pains depend chiefly on local peripheric disturbances; fugitive, erratic, or such as are affected by the emotions, or by having the attention directed to them, excite the idea of a central origin. When the pain follows the ramifications of a nerve, the periphery is probably affected. Periodic pains are central. Pains which are increased on pressure depend in general on the periphery, if the pressure does not excite the pain in a spot contiguous to the central organ, or in the central organ itself, in which case the central point of origin is certain-(pain of stomach from pressure on the vertebrae). Confessedly, however, there is much ground for deception in such cases as these, and the pain by itself is no sure criterion. Whilst, for example, in inflammations of the serous membranes pain is the rule, (though even here there is a distinction to be made, for it is much more constant in pleurisy than in peritonitis and pericarditis, where it is often entirely absent,) it is often wanting in those of the parenchyma and mucous membrane." And again, " In the same way as attention to the 'ratio symptomatum' has been advantageously employed in the analysis of the symptoms of inflammation, in the demonstration of the agreement between the physical and physiological symptoms of organic diseases of the heart, so may the special phenomena of the medicines, and consequently their special indication-principle, be explained from their established characteristic actions and organic relations in their totality, and thus a rational basis in the received sense of the old school, apparently synonymous with their 'theory,' be obtained. The particular kinds of cough, for instance, correspond to a certain extent with some uniformity to certain forms of disease. The tone of the B2 4 INTRODUCTION. cough is rough and hoarse in catarrh, in ulceration of the larynx; hissing in laryngeal and tracheal croup, and bronchitis; barking at the commencement of laryngeal croup, and in several forms of nervous spasmodic cough; sometimes hollow in ulceration of the larynx and advanced tubercular lung disease; in old subjects it is always dull, the inspirations not being deep, and the thorax not expanded. " Thus also the periods of recurrence are characteristic; in tubercular disease at its commencement the cough recurs at night, or early in the morning; in croup at night; in catarrh generally in the morning and evening. In emphysema, asthma, bronchorrhcea, there are often intermissions for a week. In nervous persons the cough is dry, as likewise in hyperwemic states, where the exudations are not fluid. The seat of the cough causes differences-not however always well marked. Since these varieties depend on special physical and physiological conditions, it can be shewn why particular medicines correspond chiefly to the dry hyperaemic, inflammatory, or the nervous, hissing, tickling, &c., cough; others again to the moist, whereby we arrive at the specific relation to the lungs, bronchie, larynx, as well as to the morbid process and its stage. Thus Aconite, Nux, Bryony, Belladonna, Conium, Hepar, Mercurius, Pulsatilla, Stannum, Iodine, Ac. nitr. differ essentially in both directions. "To keep by our illustration we may add, that an important means of distinction is derived from the expectoration, as regards its constituents, and in a less degree its taste, colour, and consistence. Attentive observation shews that the differences of this symptom lie deeply, and consequently this element cannot be a matter of indifference in the characterization of the medicines. " The constituents of the sputa may, for example, according to the essence and locality of the affection, consist of water, (serum,) air, epithelium, albumen, blood, gelatine, mucus, pus, fibrine, tubercular matter, fragments of pulmonary sub 6 INTRODUCTION. well known fact that nervous affections are aggravated in the morning and become less in the course of the day; the contrary is the case in vascular affections. In the one case the accumulating excitement and repetition of action in some measure elevate the internal energies, and increase the strength; in the other, exertion going on till evening, increases the determination of blood, and appears to bring about an increase of the evil. " Nocturnal pains belong generally to the vegetative state. On comparing the medicines which form themselves into classes according to their action at different times of the day, we shall find a point of stasis in these physiological relations. Thus, when the phenomena appear in the evening, Arn., Ars., Bell., Bry., Colch., Hell., Mere., Ac. nitr., Puls., Nitr., suit; when they shew themselves in the morning, Ambra, Amm. carb., Ammon. mur., Ant., Cin., Dros., Ignat., Nux. v., Phosph., Rhus., Verat., &c. For nocturnal symptoms besides the anti-nervous and anti-congestive medicines, China, Dulc., Ferr., Graph., Hep., Mag. mur., Mang., Nat. mur., Sep., Sil., Sulph., Thuj., &c., also suit. The influence of the digestive process, of different aliments, of tobacco, for instance, beer, &c., occasion many circumstantial and manifold pathogenetic signs, partly of an anatomico-physiological, partly of a chemical nature. The same obtains with the period of the year, the influence of the moon, of climate, of change of temperature. " Heat and cold also act differently, in proportion as the circulatory or nervous systems are predominantly affected. We call to mind here the treatment of rheumatism, of catarrh; Belladonna suits where cold alleviates (congestive states); Rhus, where heat relieves (nervous character); Cham., Mere., suit in intermediate states, where neither the one nor the other essentially relieves. But does the heat of the bed, of a stove, of the sun, make a specific difference as we find in the provings? In each case we have to consider whether the INTRODUCTION. 7 modifications are essentially connected with the character of the medicine, or are only met with accidentally. " We have, therefore, always to observe carefully the phenomena of disease, and to place a value on apparently trifling circumstances. " It will be well, however, to trace these up to their origin and causal connection. We must do the same with medicinal actions; but it would be folly to come to a decision exclusively, or principally on subordinate elements, which must first derive their true value from organico-physiological relations, and consequently are available only, as aids to the indications. The future has much to do in this. But precisely on account of this inability to refer symptoms to their seat and causes at present, we must, on the one hand, carefully observe, even where a rational theory and explanation may not be attainable at the moment, and, on the other, not reject what, employed with judicious selection, may furnish a help for the imperfection of our art." The following are Hirschel's views about primitive, secondary, and alternative actions. "An important' question for observation in medicinal action, concerns the period and order, in which the symptoms occur during the proving, on which account it is of great advantage to have exact day-books kept of the specialties of the proving. In this way we obtain one more datum for the knowledge of the parts which are immediately and specially affected by the medicine, and can lay out the course of the disease, as well as its historical development. Not less also is an important insight into the organic ramifications, the internal connections, and the causal relations of the individual phenomena by this means facilitated. Out of this observation of periods the separation into primary and secondary actions arose. " Hahnemann, for instance, styled as the primary or direct action each change of feeling called up by the medicine. This was the product of the medicine and the vital power. 8 INTRODUCTION. " This was met by the reaction of the organism, the afteraction, the indirect or secondary action, whereby it sought to replace itself in the position of integrity. The first action is a passive, the after-action an active condition. The last is the opposite of the first. Where no such opposite state occurs, the vital power establishes its action and absorbs the first action, and the normal state recurs, which is the curative action. Examples are: increase of heat in warm water-first action; decrease after the part has been taken out of the water-after action; decrease of heat in cold water-first action; increase after removal from the water-after action; diarrhoa from purgatives-first; constipation afterwards-after action; narcosis from opiumfirst; excitement, afterwards sleeplessness-after-action. " We must, however, distinguish this kind of after-action from a state to which Hahnemann gave the same name, viz., long continued actions, as paralytic states from Opium, bone affections from Mercury, &c. " Since the actions which appear in the provings are generally first-actions, these are pre-eminently the foundation of homoeopathy. " Since disease can be successfully combated only with such primary actions of medicines, they only, according to Hahnemann, are truly curative, whilst the old medicine makes use of the opposite after-action, and consequently was of service only by palliation. Hahnemann consequently, as a rule, indicated only primary actions in his Materia Medica. This separation of action perfectly accords with the Hahnemannian view of the healing process, according to which the vital power enters into a struggle with the medicinal disease. "With this Rau's and Gerstel's characterization of the after-action coincides, which the first defines to be a negation, a nullification of the medicinal actions by the organism, the last calls it precisely " a re-actionary action." "Not less do Schroen and Attomyr maintain these suppo INTRODUCTION. 9 sitions of Hahnemann. But soon opinions of a different nature arose, rejecting so artificial a division of medicinal action, and teaching the necessity of viewing them as a whole -and with justice. For exactly as in pathology the morbid process is forgotten in the division into stages, the type of the medicinal disease is lost in this artificial division into periods of action. "The whole course of the historical development is the main thing. " These views were supported by powerful arguments, particularly by C. Hering,* Piper,t Helbig,j Watske,~ Kurz.|| " It is very truly said by Trinks in another place:~ " There is not a single unequivocal criterion in our power by which the medicinal action can be distinguished from the received, supposititious counter-action, just as little as strictly morbid symptoms can be separated from the purely hypothetical healing power of nature." "And in fact we find, on considering the so-called afteractions more closely, the following observations confirmed. (1) They no more depend on the organism alone, than do the primary actions on the medicinal action alone, but they are the continued phenomena of the medicinal disease. (2) The so-called after-action is often the constipation after a diarrhoea, for instance, merely a sign, that the medicinal action has ceased, and that the organism has resumed its rights. (3) In other cases, again, the invasion of the supposititious counteraction is exactly a curative action, an alteration of tone through the medicine, so that the prover finds himself in an opposite condition. (4) In other cases these after-actions are only so-called * Arch. Bd. 15, Hft. 1. t S. Above. t Heraklides 1, S. xiv, and 2, S. xxxi. @ Bekehrung's epistlen, S. Ixxx. I| H-yg. Bd. 22, S. ccxxv. ~ Araznimittellehre II. Einl. S. xiii. INTRODUCTION. 11 foreground, where we have to do with more important elements. The law of nervous excitement, the peculiar polar vibration between one activity and another, the passage from excitement to depression, the invasion of exhaustion after an exaltation of energy, as for instance numbness after violent pain, all this is applicable to alternating action, as Kurz has very justly shown, and we may agree with him, whether with Helbig we consider them as extremes, subsiding into rest; or with Watzke, the predominance of one or other factor in one and the same process. We do not for all this overlook the influence which the doses used in the provings, their repetition, the period and duration of the action, the excitability and passivity in the functions, and other circumstances, have upon the excitement of these different states. " What Kurz says of narcotic medicines, and in particular of Opium, that in moderate doses, they call out first excitement and then torpor, and therefore they act homceopathically against pain, is applicable also to other medicines (in different doses) which call forth gradations of actions, which might easily appear to be counter-actions. By way of comfort we may add, that increasing therapeutic experience is bringing out the preponderating element in these alternations, as for example, constipation in Bryony, hilarity in Aurum. "The difficulty of distinguishing between idiopathic and sympathetic symptoms, is in some measure facilitated by a consideration of the order of the phenomena. " The last for instance, as a rule, appear later, being only of a secondary nature. "But as this later appearance is not always to be ascertained by observation, being often apparently contemporaneous, we must not attach too much importance to this characteristic. " In a paper in the 'Neue Zeitschrift fiir Hom6opathische Klinik,' (a journal edited by Dr. Hlirschel,) to be found in Bd. 1, No. xiii, and entitled ' Erliuterungen zur rationellen 14 INTRODUCTION. stances, and has led us confessedly to subtleties, which future more exact provings must place in their true light. "Thus our repertories distinguish not only nocturnal troubles, but with an adherence to the letter which seeks its like, also, symptoms evening, evening in bed, at night, before and after midnight, during sleep, in the morning in bed, in the morning, in the forenoon, after breakfast; affections from the west, the south, the north, the east wind; heat of the sun, bed, and stove; movement in carriage exercise, riding, swinging, &c. This is the point at which faith and knowlege come into conflict, and where the extremes of both lead to hasty conclusions. The critical understanding readily doubts facts and rejects them, or loses itself in hypothetical attempts at explanation, in categories, and constructions, at last in moonshine. Faith hangs on each syllable, and swears by the dot over an i. It leads to mechanical treatment, to the mere addition of a sum of similarities which is placed over against another and similar sum. To get us out of this dilemma, and to bring the incomprehensible into reconciliation with the requirements of the practical reason, there presents itself the following mode: 1. A fundamental inquiry must be made into the details of the case in question, and the order of causation in which the individual secondary symptom stands to the whole, must be ascertained. 2. The details of the proving must be examined, in order to discover whether the particular symptom is constantly found in the majority of the provers, and when it occurs singly, what kind of person the prover is who remarked it. This is the value of the symptom a priori. 3. We must ascertain in what connection with the general character of the medicine the individual apparently secondary symptom stands, and whether it may be physiologically explained by and deducible from this. This is the scientific value of the symptom--a subordinate one. 18 INTRODUCTION. Arsen., Aur., Kal. c., Lach., Spong., to those depending on disease of the heart and heart diseases! What has its fine diagnosis of these diseases profited the old school in a therapeutic point of view? At most it has introduced a ' heart diet,' and prevented mischief-Digitalis is its one and all, its Alpha and Omega. Compare, on the contrary, the cases of disease in the homoeopathic Materia Medica, the corresponding symptoms of Aeon., Bell., Ac. nitr., Chin., Ignat., Nat. mur., Nux. vom., Plat., Sulph., Verat., against the congestive and nervous forms; of Puls. and Ferr. against chlorotic and anemic states; of lod., Spig., Spong., against hypertrophy; Arsenic., Dig., Spig., Kal. c., Naj. tripudians, (according to Russell) against hypertrophy, dilatation, valvular disease. There needs only an exact science of symptoms, a comparison of particular groups of symptoms with the whole character of the medicine, in order to bring the newly obtained results of pathology into agreement with our therapeutics. " In conclusion, yet another proof from another sphere! The new pathological school has with justice laid great stress on the excretions, though they over-estimate their symptomatic significance; and in particular they pay attention to the urinary secretion and diseases of the kidney. What did homoeopathy require long before this time? She requires with regard to urinary diseases attention to be paid, not merely to the subjective symptoms, to their different kinds (dysuria, incontinentia, &c.), to the pain and the periods of its occurrence (whether before or after micturition, in order to distinguish between diseases of the prostate, of the fundus of the bladder, of the sphincter, or the urethra, nocturnal, or in the day, &c.), to the seat and origin (bladder, kidnies, blood, &c.), the causes (catarrh, plethora, organic affections, &c.), the exciting causes (fright, chill, spirituous drinks, &c.), but she has long required that the practitioner should pay attention to, distinguish, and determine the choice of the INTRODUCTION. 19 medicine according to the quantity of the secretion (much, little), the colour (pale, colourless, dark, yellow, &c.), the smell and the chemical reaction (sour, ammoniacal, basic, neutral), the temperature (hot, cold), the consistence (clear, muddy), the constituents (blood, pus, fat, gelatine, albumen, mucus, gravel), and the deposit (brick dust, clayey, salts), because such differences exist in the provings. " In short, it is difficult enough to choose according to these specific differences, but the necessity of a comprehensive inquiry into these elements has been long acknowledged by us, and our Materia Medica was the first to put itself on a par with diagnosis, in a relation valuable in practice. " What follows out of these positions and examples? There follows1st. That a rational connection may afterwards be found where at first sight it was not visible, and that therefore caution in pronouncing on individual symptoms, at present isolated, and not always to be rationally explained, is necessary. 2nd. That a Mllateria Medica, objective, keeping itself free from all dogmas, schools, and tendencies of a temporary character, must be the aim of sound physicians, and that one of this discipline will easily connect itself with the advancing progress of pathology. 3rd. That this Materia Medica can only be attained in the physiological mode, that is, by provings on healthy persons. 4th. That the homoeopathic school up to this time has alone followed this mode with earnestness and profit. 5th. That this school, inasmuch as it establishes its physiological observations yet further in practice, aims at the greatest possible certainty for its experiences; and inasmuch as it proceeds according to a settled principle, similia similibus, it is the only school which acknowledges a rational empiricism. And finally, 6th. That consequently, on all these grounds, it will easily keep pace in its therapeutics with the development of c2 20 INTRODUCTION. pathology, and especially of diagnostics, and will carry them out into practice to an equal extent, whereas in the old school the hiatus between both will be left undiminished, and must indeed become greater. " May the saying, 'qui bene diagnoseit, bene medebitur,' be also made good in regard to our knowledge of diseases, in relation to our knowledge of medicines. Then are we not merely ' ministri,' but also 'magistri naturae ' " In fact, the more we are enabled by diagnostics to unravel the distinctions of disease and to trace their phenomena, each to its proper seat, the more light shall we have thrown upon the symptoms of our remedies, and the greater will be the precision with which we shall be able to apply them. It is as if the causes which increased the range and clearness of the marksman's sight, also increased the range and accuracy of his rifle. In the advance of diagnostics lies, then, a sure ground of hope, and one tie the more by which we may be connected with our allopathic brethren, to whom we may well be grateful, when we consider that in this case they are the "cother ('oh~oi) men who labour, and we enter into their labours." Physical appliances, chemical and microscopic science, electricity, galvanism and psychology, all are ours, and combine to illustrate and facilitate the application of our simple and beautiful law of cure. On the other hand, an attentive examination and careful comparison of the symptoms to be found in our Materia iMedica may aid pathology by presenting for her examination certain invariable sequences of symptoms, the existence of which has been hitherto unknown from the paucity of recorded cases. Our pathogeneses, indeed, add the resources of experiment to those of mere observation furnished by natural disease. We have, for instance, the advantage in an artificial pathogenesy of knowing what the agent is that produces the disease; with INTRODUCTION. 21 that agent we can produce disease in every variety of constitution, and by carefully comparing such cases, and ascertaining what modifications are invariably produced by each particular well marked constitution, we may arrive at a law of constitutional reaction. We may also thus ascertain how particular classes of agents are affected by certain constitutions-not only how each agent is affected by different constitutions, but also how each constitution is affected by different agents. We have the means also of applying'in some sort the law of concomitant variations to our inquiries. If, for instance, we find that a certain well marked symptom occurs in the proving of, say, a dozen medicines, and not in those of the rest, we can inquire in what other symptom or set of symptoms those twelve medicines also agree, and set ourselves to ascertain whether any and what relation obtains between the one symptom and the other symptom or set of symptoms. If we are minute enough in our investigations, we shall probably discover in all these medicines some symptom invariably connected with the one in question, which being absent the other is absent also, between which there is also a relation of intensity, so that the one being more intense, the other is also more intense, and the contrary. There will also be found to occur symptoms always present with the one in question, but not having a clearly marked connection. In case of any doubt, or if we wish to examine for ourselves in the living body the connection of the symptoms, we have to institute provings on different individuals till we get a case in point. Much labour and patience attend all experiments systematically conducted, but no where will they be more amply rewarded. It may be remarked here, although it is not strictly in connection with the study of the Materia MJiedica, that the provings may be made subsidiary to the detection of diseased tendencies. If, for instance, a certain set of symptoms are 22 INTRODUCTION. produced in a child by a medicine, another set in another child by the same medicine, and so on, the groups bearing the general family resemblance due to the character of the medicine, but differing in consequence of differences in individual constitutions, the differences point to latent tendencies to disease or weak points, and make them manifest, so that proper homoeopathic treatment can be brought to bear in consequence of the knowledge thus obtained. This is making remedies find the game and kill it. The importance of this to the community cannot be over-estimated. The curse inherited as far as the fourth generation may thus be met and neutralized, and a due observance of the laws of health repeal it for ever. I feel confident that no one intending to make himself scientifically acquainted with homoeopathy will fail to attain considerable information from the portions of Hirschel's work which I have translated; I am sure also that a careful study of them will furnish good training for the mind, and wean it from that tendency to routine practice which disgraces the ordinary practice of homeopathy at the present time. There are doubtless many faults in this translation. I have done my best, however, to attain accuracy. Dr. Hirschel's style is elegant; all faults on that score must be those necessarily belonging to a translation, or due to my awkwardness. RULES FOR THE STUDY OF PHARMACODYNAMICS. (a.) As regards the mode of conducting the enquiry in relation to the whole Materia Medica. THE special object of the study of the Materia Medica must ever be the knowledge of the curative action and the practical employment of medicines in appropriate cases. The homoeopathic student will be compelled to observe with a certain resignation that the road to the knowledge of the Materia Medica is not with us, as it is with the allopaths, a broad and open one. The proper fundamental text of their Materia Medica, which consists in clinical indications for employment in special forms of disease, entirely fails us. We have to attain this knowledge by a tiresome study for ourselves, conducted according to the rules of art, and this after a two-fold mode. (a) The study of the pharmacodynamical character of the medicine, with a view to its clinical applicability in a special case. (b) The construction for ourselves of special indications, ad usum in morbis, out of the general physiological actions of the medicines. Both methods must be combined with one another. We follow the first method, when we find in a repertory or in a work of special therapeutics, a medicine for a special case. 24 RULES FOR THE STUDY OF We follow the second, when we study the Materia Medica regularly, medicine by medicine, with a view to pure pharmacodynamics, and not with reference to any special case. Never, however, must the study of special therapeutics supersede that of -the Materia Medica, or be unaccompanied by it. The practical extension of homoeopathy requires the contemporaneous connection of both studies. We shall do this in the best way by commencing our study of cases of disease with such as characterize the indications of cure; we specially recommend in this respect the first volume of the Homoeopathic Archives, where the cases recorded by Gross, Hartmann, Hartlaub, Haubold, Schubert, XEgidi, Wislicenus, Stapf, M. Mueller, and others, exactly answer this object. Many of the cures may be possibly due to nature; an improved pathology may possibly detect many sins of omission, yet have these cases, as we have said, the merit of giving accurate descriptions of disease and clear indications for the choice of the curative agent. The Hygea also, the practical contributions of Thorer, the Journal of Homoeopathic Clinique, the Homoeopathic Studies of Wurmb and Caspar, and Ruckert's Collection, contain good materials for this purpose. In this course of study when we meet with a medicine which has effected a cure, we must look for it in Hahnemann's Materia Medica Pura, and then review, not merely the symptoms for which it was used in the special case, but also its whole sphere of action, so as to form for ourselves an idea of the agency of the medicine in this case and in general. This attempt will at first prove rather rude; but the oftener a medicine is mentioned in cases of disease, the oftener we review its general and special action, the greater number of fixed points we shall obtain. Let us now take up a work on special therapeutics, (up to the present time that of Hartmann, if not the only one, is at least the most complete,) or a good monograph, and peruse the corresponding chapter; when, for instance, we have met in the 3rd vol. 1-78 of the Archives of Stapf and Gross with the case of pneumonia, in which Aconite and Bryony were employed, let us read the section on acute pneumonia in PHIARMACODYNAMICS. 25 Hartmann, or in the Homoeopathic Quarterly Journal of Mueller and Meyer, or in the Clinical Studies of Wurmb and Caspar. Here we find a number of medicines with more or less accurate indications. Compare these with the text of the Materia Medica Pura, and we shall gradually become more at home with it: individual points will combine as in a crystallization, and form centres around which related symptoms may group themselves. In this way we follow out the synthetic and the analytic modes at the same time. This mode of investigation should also at an after period in practice never be omitted in making use of the repertories, or a work on special therapeutics, which must never be allowed to supersede the contemporaneous reference to the general action of the medicine. After this specially clinical course of self-instruction, we may now proceed independently with the study of the Materia Medica. For this purpose with the view of forming at once a general view of a medicine, it will be well to make use of Noack and Trinks' Manual. We- may then proceed for ourselves with the study of each individual medicine. Where we have this before us in the later provings, as in those of Vienna, the key to the enquiry is easily found; we require only to make an abstract, a condensed arrangement of characteristics already, without any trouble of ours, prominently brought out. Where, however, the old form of the Materia Medica Pura and the chronic diseases of Hahnemann is retained, as it is in the Homoeopathic Archives, in the Hygea, in the General Homoeopathic Journal, in the provings of Hering, &c., the student must search out for himself the characteristic physiological points, and sketch out for himself out of the individual symptoms a diagnosis of the whole medicinal disease, and from the component parts of this disease particular types, which answer to natural forms of disease. This constant reference to the practical side may easily mislead, if we have not previously made a picture of the general action, and to this individual forms must always be referred. It is not easy to create such a characteristic type, PHARMACODYNAMICS. 29 view. Such are:-Aconitum, Belladonna, Bryonia, Mercurius, Nux vomica, Pulsatilla; Champmilla, Ignatia; Cocculus, Rhus, Dulcamara, Arnica; Phosphorus, Acidum phoshoricum, China, Camphora, Arsenicum, Carbo vegetabilis and animalis; Sulphur, Lycopodium, Sepia; Calcarea, Silicea, Hepar sulphuris; Ipecacuanha, Veratrum, Coffea, Hyoscyamus. In the second series stand as semi-polychrests. Colocynth, Opium, Stramonium, Cicuta, Staphysagria, Spigelia, Conium, Cina, Platina, Zincum; Acidum nitricum, Petroleum, Thuja, Graphites, Baryta carbonica, Ferrum; Stannum, Aurum; Kali carbonicum, Digitalis, Helleborus, Ledum, Cannabis, Cantharides; Drosera, lodium, Spongia; Antimonium crudum, et tartarisatum, Natrum muriaticum, Magnesia muriatica. The following medicines form a third series.Ammonium, Acidum muriaticum, Acidum sulphuricum, Kreosote, Crocus, Sabina, Secale cornutum; Cuprum, Moschus, Valeriana, Nux moschata, Bismuthum, Asa, Angustura, Agacus muscarius, Ambra, Anacardium, Capsicum; Agnus castus, Clematis, Colchicum, Squilla, Sassaparilla, Guaiacum, Oleander, Rhododendron, Ruta, Mezereum, Bovista, Borax, Alumen, Plumbum. To these medicines the remaining ones will connect themselves the more suitably, as the greater number of chronic cases, for which these medicines are chiefly required, admit of more leisurely study. Solemnly, however, do we repudiate the idea of any preference being given to any medicine by this arrangement; and we protest against any exclusive favour being shown it in practice on that account. Each medicine is in turn the best where it suits, and he will do ill who limits his use of the medicines to the circle of those with which he is most familiar, or to which he is most partial. The practice of the physician is, moreover, of so varied a character, that at the very outset of his career cases may occur in which the medicines of most unfrequent use may find their fitting place. Constantine Hering sketches a very true picture of a practice without a proper knowledge of the 30 RULES FOR THE STUDY OF Materia Medica, when he says,-" In the greater number of cases of every day occurrence, will these favourite medicines be given where they do not suit, and can do no good: a number of medicines will be used on account of single symptoms, a still larger number will be entirely neglected. In important and rare cases, where the greatest diligence is given in seeking out the proper remedy, this sudden exertion is of no use, so that of two medicines the right one cannot be selected, or perhaps not a single one seems to suit." (b.) In regard to the study of each individual medicine. With regard to the particular study of each individual medicine, it is important, at first by anticipation as it were, to form for ourselves in broad and comprehensive outlines, an idea of the sphere of action of the medicine; then to acquire an insight into the anatomico-physiological or local-specific relations, that is to say, a knowledge of the parts, organs, systems, tissues, &c., on which the medicine acts; then to ascertain the tendency and mode in which the medicine acts -or the morbid process, and so to arrange the symptoms into groups, as that out of them the pathological states and special forms of disease may naturally proceed. With these we must learn the exact connection of the circumstances which exercise an influence on the production, amelioration, and aggravation of the symptoms. We thus open out to ourselves a view into the setiological relations; for example, the action of the open air or chill; of indulgence in alcoholic stimulants; the order in which these changes stand in regard to particular functions, whether, for instance, they occur before, during, or after a meal, or an alvine evacuation; the connection in which these groups of symptoms stand with one another, as may be gathered from their contemporaneous occurrence or close succession; for example, headache with gastric states, cough with vomiting, sleep with febrile state, &c. Lastly, the mental states produced by the medicine are very important for a knowledge of its individual nature. In order to ascertain these important points, we must carefully put together the details. We must then institute com PHARMACODYNAM1CS. 31 parisons in regard to the symptoms and the phenomena, and "where we can get them, with regard to the individualities of the provings, then certain diagnostic characters will assume a certain constancy and importance, in proportion as they develope themselves equally among several provers, and in a stiking way. From the characteristic anatomical signs, which are to be mutually compared at first in individual parts, as the head, chest, &c., then in their collective aspect, we are not to understand the organs and particular systems merely which are acted on, but by deeper inspection must learn to distinguish the predominant histological and general elementary states to which the medicine is specially related. When we have done this we have advanced far towards a knowledge of the pathological process and its quality. Thus, for example, after a proper observation of the mtiological points, of the general character and of the particular appearances, affections of the glands easily lead us to scrophulosis, of the mucous membranes to catarrh, of the fibrous membranes to rheumatism, &c. Connections between particular anatomical parts and physiological functions will conduct us to the phenomena of one set from those of the other; for example, affections of the pleurm to the peritonceum, heart and lung affections to liver and kidney affections, those of the skin to the kidnies, those of the urinary apparatus to the serous membranes, as in dropsy. Many mental states point to heart, chest, and abdominal affections. The feelings and indications of temperament to affections of the liver and digestive apparatus. Equivalent states should be arranged in the mind together, for example, congestive phenomena and inflammations of particular parts. As we compare symptoms, types of disease will at first spontaneously arise, which, however much they may differ from the forms hitherto known, yet will recall to our recollection certain states, which are current among certain nosological characteristics. We have in our minds, for instance, the forms of cramp in the stomach produced by Nux PHARMACODYNAM ICS, 33 process. On this account we observe the places where they occur, as. well as their kind. We have seen that certain kinds of pain answer as much to the anatomical part, as to the fundamental character of the disease. Drawing and tearing occur in the muscles, shooting in the serous membranes, cutting in the abdomen, tenesmus in the bladder and rectum, an ache or pressing pain in the head, squeezing in the ears, boring in the bones, pain as of bruise in the muscles and joints, pain as of excoriation in the capillaries, burning in the mucous membranes, the external skin, in the vessels (the blood itself?). The preponderating kind of pain must consequently be especially indicated among the general characteristics. To this must be added besides, the particular circumstances under which the symptoms occur, are aggravated, or ameliorated, as the time, movement, air, heat, pressure, the influence of particular acts, as of eating, drinking, going to stool, &c. And here the particular symptom affected by the cause must be borne in mind, as well as the cause itself. These conditions or circumstances lead us back as we have before observed, to aetiology and pathology. The influence of the period of the day distinguishes between nervous, congestive, and vegetative affections; aggravation in the open air points to a rheumatic diathesis; aggravation after eating to a dependence on the digestive apparatus, &c. We must beware, however, of supposing the contrary. For instance, it by no means follows that movement relieves where rest aggravates, and vice versa. Dulcamara, for example, has many symptoms which are better by movement, but very few which are worse at rest. It we cannot discover the physiological causes of these changes in every case, yet does experience shew us that precisely these above-named points are connected with particular diseased states, and even when this cannot be previously ascertained, yet do they always provide such characteristic diagnostic indicatioans for the particular medicines, that their retention among the general signs is indispensable. If we have now by this mental operation seized gradually the general characteristic appearances of a medicine as they D PHARMACODYNAMICS. 35 J: Meyer also has the merit of great clearness, and of having successfully cultivated this stony field. What we miss in his studies of Aconite and Platina, which are rather loosely handled, he has given us in that of Sepia, which bears the marks of proceeding from a well established basis; for we have not merely a clinical use of the symptoms, as before, but a general, deep, physiological characterization is presented, in which the partial constraints of unity, and the hypothetical character of many assertions are willingly pardoned on account of the consistency and the simplification which are consequently attained in the monstrous complexity of the Sepia-symptoms. I shall, myself, now proceed to attempt a study of two medicines, Bryonia alba and Rhus toxicodendron. But these studies differ partly in the kind and mode, partly in their tendency, from the above named systematizations; for I do not, as the above named writers do, proceed from the stand-point which they justly take of teachers, of men who are conscious they understand the medicine before them, but, inasmuch as these representations are intended to exemplify the way and mode in which the study of a medicine is to be undertaken for one's-self, I suppose myself to be a learner, who, unacquainted with the medicine and its properties, wishes to create for himself an idea and acquire a knowledge out of the materials before him, and must consequently treat them in a purely objective manner. In the consideration of what follows I would request this to be particularly borne in mind. The previous instructions and rules for the study of pharmacodynamics will thus, in some measure, find a visible and formal realization. Previously, however, I must be allowed a few hints on the methods which are here employed. The representation on paper, which is always necessary, in greater or less extent, pre-supposes a division of the schema into particular sections, because this trouble is not taken in the Hahnemannian Materia Medica, and indeed the operation is impeded by the separation of parts that belong to one another. We are often, therefore, compelled to make ) 2 41 HEAD AND SCALP. GIDDINESS,* (sympt.............................. 1, 2, 3, 6, 7, 9, 10, 11, 12, 17, 56,) as if one were turning round, or as if every thing were turned round him (s. 2). A dull, giddy, oppression (s. 3) in the head. Giddiness, as if intoxicated, (4, 5, 7,) and as if the blood mounted violently (s. 4) to the head. Giddiness, with feel-............................. ing of WEIGHT, (9, 22, 30, 31, 32, 51, 52, 56,) as if every thing turned round in a circle (9) Giddiness and FUL- in the head (10). NESS (10, 18, 58) Giddy, with sense of.............................. whirling, and an unpleasant sensation in the middle of the chest, as if faintness was coming on (11) Giddiness, so as to.............................. stagger backwards and threaten to fall (12, 13) STAGGERING (8, 12,....................... 14, 16,) to both sides, as if he could not stand up firmly (14) She staggers to one............................. side (15) Giddy in the head.............................. and weak in the limbs (17) when standing (s. 2), as soon as he got up from his chair, disappearing after walking a little (s. 6). whilst sitting (stooping) and reading, disappearing on rising up (56). on sitting up in bed (11). on standing in the evening (12); on attempting to walk (13). during walking (14); in the morning on getting out of bed (16). after movement (15, 38, 42, 75); while standing (15). the whole day. * The numbers affixed indicate the order of the symptoms according to Hahnemann. The frequency and coincidence is given by the numbers. Exactly equivalent symptoms are omitted. 4.2 RULES FOR THE STUDY OF Dull movements in the head, which occasion giddiness and stagnation of thought (19) More BEWILDERED than giddy (20) So weak in his mind that his thoughts vanish; as if about to faint with heat (21) Hallucination, his own head seems much too heavy to him (22); like a hundred weight (30, 31). STUPID in the head (23,26); with excessive deficiency of memory (23, 29); the thinking faculty is impeded (26); cannot collect himself (29). She forgets what she is about (24, 25); and lets every thing fall out of her hands (25) He asks for things which are not present, (27), which when obtained he will not have (28). Great weight (32), and pressure (32, 38, 40, 43, 44, 45) STUPEFACTION (33) Confusion (34). Gloominesss (35, 37) as after a debauch (37). HEADACHE (36, 37, 41, 42, 52, 53, 54, 57, 60, 61, 62, 63, 71, 75) in the region of the vertex and forehead. in the head. in the face................ chiefly during standing. of the whole brain from behind forwards (32) of the head............ (in the room), worse on lying down (24). whilst stepping out (38). till bed-time (35); he will not get up (37). beginning early in the morning, not on getting up, but on first opening and moving the eyes (36) early while waking (37). PHARMACODYNAMICS. 43 Dull pain (39) Dull ache (40) Throbbing pain "(41) in the occiput. in the occiput. in the forehead......... compelling recumben cy. Digging ache (42) in the anterior portion of with pressure to the the brain forehead "Pressive pain (43) Pressure from within outwards (44, 52, 53, 57, 59). Semilateral headache of a pressing kind Obscure compressive pain (46) At first congestion of blood; then followed a feeling of compression Feeling of compression (48, 49, 50) With jerks, like pulsations (50) Heaviness of thehead (51) as if it were stretch in the forehead. over the left socket in the brain, passing into a pressure on the eyeball from above, inwards (44); to the forehead (53). and in the eye, of the same side. in the forehead and the eye. to the head (47). from one temple to another (47). from one ear to another (48); on both sides of the head (49). in the brain. especially on stooping and walking quickly, a walk tires him much, so that he can hardly stoop (43), while taking a walk and after dinner (53). she could not raise her eyes for pain; on stooping she could not raise herself again (51). and great desire to lie down. while walking and after dinner (53). ed-out, intermixed with SHooTs (51, 57, 67 -70). Violent headache, like a great weight, as if he must nod on all sides, with pressure outwards (52) Pressure outwards (53, 57) Feeling as if all in the brain. in the forehead (53). 44 RULES FOR THE STUDY OF would fall outwards' (54, 55) Pressure outwards (59) Feeling as of an expansive pressure (58, 60) Headache, like a weight which presses on a sore place (61) Semilateral headache like a digging pressure Like a sort of digging or tearing (62) A twitching drawing (63) A jerking tearing (64) Tearing pain (65, 66) Shoots (67, 68, 69, 70) "Whirling sensation. (70) Headache, with HEAT IN THE FACE, rather jerking than throbbing (71) Painful throb bing (72, 73, 75) towards theforehead (54) 1 on stooping (55). in both temples. of the skull. in the occiput, to the shoulders. on a small spot of the right hemisphere of the brain (62). along the bones of the upper and lower jawbones downwards (62, 63), in connection with a painful submaxillary gland. in the malar and jawbones. from the right malar bone to the right temple upwards. in the left side of the head (65); over the forehead superficially, then in the muscles of the neck, then in the right arm (66). in the head through the temple (67); from the forehead to the occiput (69) in the right side of the forehead. externally, more violent on touch. while walking in the open air. also perceptible externally (72); quicker on movement (75). (above, (73) on the vertex) Pain, hollow throb- in both temples. bing, (74); chirping as PHARMACODYNAMICS. 45 of grasshoppers (76); gurgling (77) Pain, as if any one in the temples (78). was pulling the hair (78) Burning pain (79) above, on the head, not painful on touch. Headache (80) in the forehead; especially on touch. Feeling of excoria- on one side of the oc- on handling it. tion (81) ciput, Smarting, gnawing itching on the scalp, (at night) (82); on (82) combing the hair (84). Great greasiness of the hair (83). Conclusions from the foregoing. As to the locality, we find both the whole head and particular positions of it affected. Especially affected are:-the anterior part of the brain, the frontal portion, the region above the eyes, the temples. From this we learn that the first Branch of the Trigeminus is affected by the medicine. One-sided, semi-lateral affections occur only as detached symptoms. The General and Internal Oppression of the Brain indicates affections of a serious character. That these extend themselves to the Skull, the Bones, speaks for a material obstruction, probably for an effusion of fluid; S. 58, 60, point particularly that way. The kind of pain and the termination of the inflammation may lead us to an affection of the Serous membranes. There are also for affections of the Muscles, and Fibrous membranes, indications in the tearing pain. Among the symptoms are predominant,-the phenomena of abnormal Circulation, Hypercemia, Congestions in the Vessels, Inflammation, (compare symptoms 1, 5, 8, 9, 10, 13, 19, 41, 47, 54, 70, 71, 74, 76, 77). These, and the remarkable heat in the face (20, 47, 71) show that the phenomena are not purely of a nervous character, but depend on Congestion. The kind of pain gives special support to this view; it is 46 RULES FOR THE STUDY OF now pressive, now digging, now like a pain of soreness, and now a throbbing. The squeezing, compression, tension, andc distension, are only varieties of this pressure. This manifestly points at hypercemia and inflammation. The shooting pains indicate inflammation of the serous membrane (meninges), aggravation by movement (stooping) speaks far for a congestive, that by touch for an inflammatory character. The obscure movements, with giddiness and suspension of the thinking faculty (19), the confusion (20), vanishing of the thoughts,-further the S. 23, 24-29, the dull pain point to oppression of the internal parts of the brain, and particularly (a) to an affection of the Sensorium; (b), to a commencing Deterioration of the Sanguification, as is usual in organic diseases, in typhus and other nervous conditions. The squeezing and pressure appears more in the central parts, from within outwards (51, 53, 59, 88), particularly as if all would fall out at the forehead. This we find as well in mere hypercemia, as in organic diseases of the brain; it points particularly to Decomposition, to an Effused Fluid, (compare heaviness, tottering, &c.), Exudation, Dropsical Collections. Besides we find frequently-Jerking, Tearing, Digging. These last kinds of pain are indications of nervous affections, which depend principally on congestive states, as also on organic changes lying more deeply, to which the Twitching and the Gurgling are also to be referred as symptoms of organic disease of the heart, with hypercemic diathesis. The extension of the tearing to the face, &c., indicates a neuralgic affection, which may have, probably, a congestive or an inflammatory character. Whether the open air causes aggravation, is not yet ascertained (rheumatic?). On arranging these observations under a clinical point of view, we find the following principal forms of disease correspondingly indicated, and provided that the precise phenomena suitable for Bryony are comprehended in the choice, they will be indications for its employment. PHARMACODYNAMICS. 47 I.-ABNORMAL CIRCULATION (HYPEREMIA) OF THE BRAIN. (1.) Congestive states, especially to the anterior part; headaches of that sort. (2.) Inflammations of the brain and of its meninges, especially where nervous phenomena or exudation, effusion of fluid threaten, or are already present. (See II.) II.--ABNORMAL SANGUIFICATION, COMMENCING ORGANIC DEGENERATIONS. (1.) Second stage of inflammation. (2.) Hydrocephalus acutus. (3.) Typhus? Compare the fever symptoms. III.-NERVOUS DERANGEMENT (HYPEREMIC). (1.) Affections of sensation in the head. (2.) Neuralgia of the trigeminus. (3.) Hemicrania. IV.-RHEUMATISMUS? (HYPERGEMIC TEARING IN THE HEAD). To get a more exact knowledge of the idiopathic or sympathetic nature of the head affections, and for forming groups of symptoms, compare the (1.) Gastric affections. (2.) Fever symptoms (on account of the headache, stupefaction, gloominess, forgetfulness, &c.). (3.) Symptoms of the extremities (on account of rheumatism). As to the scalp symptoms, they are either extensions of the so-called hyperoemic or nervous states, or have to be compared with the skin symptoms. We may remark that the Vienna provings (see Oestr. Zeitschr. f. Hom. iii. 1.) has more than one hundred symptoms belonging to the preceding section, (Hahnemann only seventy-eight) which are more clearly marked, inasmuch as they give the seat and kind of pain with greater precision. The pathologico-anatomical appearances (redness, vascular injection, plethora,) confirm the above given conclusions from the symptoms. 48 RULES FOR THE STUDY OF FACE. Painful THROBBING, in all parts of the face (85) Itching prick- in the right frontal ings, like those of muscle. needles (86) Tension (87, 91) in the frontal muscle under the skin (87) in the skin of the face (91). HEAT, with REDNESS, in the head and face. also perceptible under the fingers. on moving the eyes (87); or the muscles of the face (91). (88, 89, 90); passing (90) Red spots (92) Paleness of the face (93). Red, hot, soft swelling (94) SWELLING,with some PAIN (95, 96) A small impetiginous pimple (125) in the face and neck. of the face. of the left side of the face, more down along the nose (95); of the upper half of the face, under the eyes and over the root of the nose, with swelling of the eyelids (96). on the right cheek. Conclusions. The Fifth Pair is affected here also, especially the frontal and supra-orbital nerve, as well as the anastomosing nerves of this with the facial. Compare symptoms 86, 87, 91, 95, 96. The forms of disease are:I.-Neuroses with hyperoemic (inflammatory) character. (Compare painful throbbing (85), itching pricking (86), tension (87, 91), as Inflammatory prosopalgia. II.-Rheumatism, as Rheumatic swelling of the face. Compare further on, 50 t0RULES FOR THE STUDY OF Weakness of sight, all the letters run into one another (110). Presbyopia; can only see at a distance (111) Redness and INFLAMMATION of the lower, quivering of the upper (112) Pain of soreness and excoriation (113) Smarting, as from sand, compelling one to rub his eyes (118, 119) Sudden SWELLING of the eye, and pain without redness; matter oozes out, dark redness and swelling (120) Itching, with burning and tearing (122) Itching, mixed with smarting, not to be removed by rubbing (123) eye-lid. in the inner angle of left eye. in the eyes (118); in the right eye (119). of the conjunctiva. at the border of the left upper eye-lid. in the outer angle of the left eye. Conclusions. If we treat of the parts affected first, we find the muscles, the eyelids, the angles of the eyes, the conjunctiva, and the whole ball of the eye. We have to add to the elements already recognised as affected by Bryony (the blood, the nerves, the sero-fibrous membranes, the muscles,) the Cellular and the Mucous Membrane. As before, we find predominantI.-HYTERCEMIA. (1.) Congestive states of the eye (throbbing). (2.) Inflammation of the lids, canthi, Conjunctiva (pressive ache, constriction, smarting, excoriation; redness, swelling, pus,) and indeed since the Mucous Membranes are attacked, and the air is brought into play, there is produced as a special kind of Bryony-inflammation, the Catarrhal. PHARMACODYNAMICS. 51 II.-The NEUROSES. (1.) A continuation of the neuralgia of the first branch of the fifth pair, nervus frontalis, naso-ciliaris, lacrymalls, (S. 97, 102, 103, 104, 106, 115,) (smarting, itching) = an affection of the cutaneous nerves. Are these eye affections independent? Experience teaches their sympathetic constitution; consequently compare further on, (1.) Mucous membranes of the air passages, &c., for the Catarrhal affections. (2.) The skin symptoms for the Exanthemata (measles). (3.) Gland symptoms for the Scrophulous nature of the eye affections. N.B.-S. 110 is connected with cerebral affections. S. 111 is too isolated and questionable. THE HEARING AND EXTERNAL NEIGHBOURHOOD OF THE EAR. SWELLING, (126, 135, 136,) with burning pain RINGING, as of small bells, (127) A constrictive pain with DYSECOIA, removed by removing the wax, but only to return (130) Feeling as if a finger were pressed on it (131) Dull pain (132) Burning from within outwards (133) Burning (134) Hard LUMP, which often changes its size (135). of the right cheek,close to the ear (126). before the left ear. in the auditory canal. in the meatus auditorius externus. round about the left ear. in the left ear. in the lobule. behind the ear. which increases on stooping, while reading. E2 52 RULES FOR THE STUDY OF A pustular swelling, which burst in twelve hours, and FORMED A YELLOW CRUST (136) Humming (137) Sensation, as if the ears had been stopped (138). Shoots (139) Discharge of BLOOD (140) Violent pressive pain (141) ULCERATED before the ear. before the right ear. first in one, other ear then the during a walk in the open air, and on his return to the house. I from the ears. in the right external ear. external ear (142). Conclusions. The seat of the symptoms is chiefly the outer ear, thoug] the meatus, and without particularization, the ear itself art said to be affected. Throughout, the affections of the Mucoum Membrane come out prominently. The clinical forms are here likewise. I.-Hypercemia-(pressive ache, burning, shooting, dysecoia, swelling; the open air and stooping aggravate). (1.) Congestive states, connected with cerebral affections (S. 127, 137, 138,). (2.) Inflammation and Catarrh of the inner auditory passages. (Dysecoia dependent on congestion and catarrh.) (3.) Swelling about the ear, connected with deposition of coagulable lymph; affection of the cellular membrane. II.-Neurosis. (1.) Neuralgia of the external ear in connection with hemicrania, congestion to the head (S. 130, 132, 134, 141,). 544 RULES FOR THE STUDY OF EXTERNAL PARTS OF THE THROAT AND NAPE. Drawing, with pres- in the throat up to the sure (158) ear. Pain (159) in the posterior part of the throat Tensive STIFFNESS of the left side of the (160) neck. RHEUMATIC STIFF- from the side of the NESS (161) neck to the nape. Tension (162) in the nape Itching prickings, on the neck like needles, provoking scratching, and disappearing afterwards (164). Red MILIARY RASH (194) A smarting, itching rash (197) Pain of excoriation (163) perceptible on movement. on moving the head. especially after walking quick. especially after perspiration. on movement, impeding turning of the head and chewing, even to preventing it. in the neck. round the neck on the left side of the nape of the neck, and neck, of the facial and masticatory muscles Conclusions. The nerves, the muscles, and sinews, the cellular membrane, the external cutaneous parts. are affected in a similar way with the preceding parts. For we observe,(1.) An inflammatory state (S. 159, 163,). (Aggravation on movement is worthy serious consideration here). (2.) A neuralgic (S. 158,) through the anastomosis of the trigeminus with the sympathetic and spinal nerves. (3.) Rheumatic (S. 160, 161, 162, 192,), and (4.) Exanthematic affections (194, 197,). Compare for No. 2, the face symptoms; further on for 3, the nape and limb symptoms; for 4, the skin symptoms. Remar:k-Kammerer in his Metaphlogosen des Zellgewebes, considers the Vienna provings acs doubtfil, that is, as sympathetic consequences of arfginw. PHARMACODYNAMICS. 55 THE CHIN AND PARTS CONNECTED WITH THE MAXILLARY BONES. Painful pressure(127) under the right malar Pinching pressure (128) A pimple, with stinging pain (157) Pain, either simple or as from a pinch (191) Feeling as if a little knob on the bone, with tensive pain (193) bone in the right joint of the jaw on the chin in one of the submaxillary glands. on the lower jaw. disappearing from external pressure. more violent on movement. on being touched or turning the head. on touch, and on turning the head. Remark.-S. 163 partially belongs here also. Conclusions. These symptoms bear the stamp of being sympathetic, and indicate (1.) Neuralgia of the trigeminus through anastomosis of the zygomatic nerve with the second branch, and with the facial nerve? S. 127, (touching relieves/) S. 193. (2.) Muscular affections, S. 128, 191? 163. (3.) Cutaneous affections, S. 157. Fissure (165), burning (166). Small ULCERATED PATCHES, with burning pain, (167) A small elevation, from time to time BLEEDING violently A VESICLE, with burning pain (169) ERUPTION, smarting (170) THE LIPS. in the lower lip. on the lower lip on being touched. on the right corner of the mouth, but rather on the lower lip. on the red of the under lip. under the left corner of the mouth. PHARMACODYNAMICS. 57 '(176); drawing (176, 177); sometimes jerking tooth-ache (182) SLooseness Tearing, shooting tooth-ache (182) Feeling as if the tooth were screwed in and then raised out of its socket, with tearing in the cheek and pinching in the ears (183) Tooth-ache, as if cold air were penetrating to an exposed nerve in a HOLLOW TOOTH (185) Pain, as of SORENESS Pain, of rawness and soreness when shaking a tooth (187) All the jaw teeth feel too long! (188, 189)! they are so LOOSE that they can be moved too and fro (188) SPONGY of all the teeth (178) passing even to the cervical muscles. in the tooth (185) in the gum. perceptible on being felt or on clenching the teeth. worse on eating and warmth. at night; relieved for an instant by cold water, better on walking in the open air. worse on lying on the unaffected side, removed by lying on the affected side. on drinling something cool. she cannot bite with them, and when she tries, there is a pain as if the teeth were falling out: early on waking. gums. Conclusions. These pictures of disease are excellently sketched. The character of Bryony, even if all the tooth pains were merely sympathetic, would only be the more confirmed. Very clearly we perceive it as I.-An action on the circulation. (1.) The nervous, irritable, principally congestive toothache (hence that of pregnancy). (2.) The inflammatory toothache, especially the affection of the periosteum and the gum: (the kind of pain, the elongation, looseness of the teeth, the being screwed in, dependent on an exudation at the periosteum of PHARMACODYN AMICS. swollen and full of mucus, which cannot be hawked up (202) SORE-THROAT; DRY Sand raw (203, 204)..on swallowing. in the throat (203); during empty deglutibehind and above (204). tion; during awaking; disappearing after a short time, then returning; worse in a warm r-oonz (203); in the evening (204). Conclusions. An unmistakable form of angina, faucium, and tonsillaris, which is evidence for the inflammatory action, the affection of the mncons membrane, and the chill element. Compare further on: The mouth, stomach, and bowel symptoms for the gastric (catarrhal) character., INTERNAL PART OF THE MYOUTH. (The Tongue, Thirst, and Taste symptots, &0c.) FEELING OF DRYNESS (205) VESICLES, which burn and smart (206) Dryness (207-211) sothatthetong-te sticks to tbe roof of tbe mouth (207) Without thirst (208, 210). Much THIRST, without heat (212) Violent thirst, (213 -216) twenty-two days long (213) Tim,~ SALIvA RUNS FROM HI-M INvOLUNTARILY (217, 218) not on the tongue, but above on the palate. on the anterior border of tbe tongue. in the mouth (207, 209) merely within the upper lip and the upper teeth (211) early (209). in the m72o42n-ing....................Iin the day. especially in the morning (214); night and day (215); after eating (216) out of the corners of the mouth (217) 60 RULES FOR THE STUDY OF Accumulation of much soapy, frothy saliva (219) Very WHITE coated (220) FLAT, SWEET, nauseous taste (221, 222, 225) Disagreeably insipid taste (223, 224). HE HAS ALMOST NO TASTE (223). Almost no taste,when not eating it is BITTER (226). Everything tastes bitter (227, 228, 229, 264); he can swallow no food (227) in the mouth. tongue. in the mouth. in the palate (228); in the mouth (229) Taste as if the teeth............................ were FOUL, or of putrid flesh (230) in the mouth A RANCID, SMOKY taste (233) rises into the throat Putrid SMELL (232) from the mouth (232) remained constantlyafter dinner (228); in the morning (229); in the evening after laying down (264). in the morning when fasting, not during eating (231). late in the evening. Conclusions. These pathogenetic actions form for themselves no exclusive physiological group of symptoms, but receive their completion through others., Manifestly affected are the mucous membrane of the stomach and the intestines,-the bilious system. We have consequently to compare further on. (1.) The symptoms of the stomach and intestines, on account of the gastric (apthous) and pituitous character (S. 220). (2.) The hepatic and bilious symptoms, on account of the predominant bilious character now presenting itself for the first time. (3.) Symptoms of fever and inflammation, for the sympathetic affections of these tissues in febrile and in-' PHARMACODYNAMICS. 61 flammatory states (compare the symptoms of dryness and thirst). (4.) The S. 217-219 point to cardialgic troubles. See stomach and abdomen symptoms. Remark.-The tongue symptoms are more decidedly expressed in the Vienna provings, and speak especially for aphthce, see above, 167. STOMACH. (Gastric symptoms, Hunger, Appetite, Risings, &c.) Loss OF APPETITE without bad taste (234, 236). SPOILED APPETITE (235). The stomach is empty; HUNGER without appetite (237, 239) Nothing has a relish (246) Morbid hunger with loss of appetite (238, 244) Constant NAUSEA, (240) and immediately after morbid hunger, (240, 245). Morbid hunger, with THIRST and FUGITIVE HEAT (241) Violent hunger for fourteen days (242). Much too great desire for food for six days (243). He has no appetite for milk (247) in the morning when fasting (238). in the morning (241); till night (245). but when he begins to take it his appetite returns and it begins to relish. DESIRE FOR MANY THINGS, which he can RULES POR THE STUDY OF not eat when he gets them (248). The food smells nice (249) Desire for WINE (250); for COFFEE (251); strong (252) frequent empty RISINGS (253) (259) After a rising mHcCOUGH (254) for a quar. ter of an hour (255), violent (256) Violent risings (257) with the taste of what has been eaten (258) Rising, with BURNING taste in mouth, and MUCUS in the throat (260). At each eructation a shooting pain (261). Burning, almost incessant, eructations, which make the mouth rough and hinder the taste for food (262). A BITTER, DRY TASTE, which remains so dry in the anterior part of the mouth, without thirst; the lips are dry and split (263) Eructations, at the last BITTER (265, 266) Bitterness comes into the mouth, with eructations, with VOMITURITION (267). SOURISH eructations (268, 271) ACCUMULATION OF ~~~~~~~~~~~~~~~~~I but as soon as he begins to eat, his appetite goes away. not after drinking, but after the slightest food (259) without having eat any thing before (254). after eating,from morning till evening (257).............................. after eating............................ after eating. ~)1~~~~~~~11~~1 )~~~~~~~~~ after eating. PHARMACODYNAMICS. 63 SOURISH WATER IN THE MOUTH (268) Vomiturition (269, 274, 279, 283, 284,) without being able to vomit, and frequently empty eructations (269) Nausea, (278, 272, 273, 283, 284,) with much.flow of water from the mouth (272) Frequent VOMITING of YELLOW and GREEN MucUs (275) He awakes with nausea; vomits BILE and FOOD (276) Food comes by a sort of INTERNAL MOVEMENT, like a regurgitation, into the mouth (277). Regurgitation of the contents of the stomach almost without an effort (278). Vomiturition and NAUSEA (279, 283, 284) Vomiting of solid food but not of drinks (280). HEMATEMESIS, is obliged to lie down (285). Vomiting of a bitter damp and putrid liquid, the taste of which remains in the mouth (286) ~~~~~~I~~)~~~~~~~~~~t~~~~~~ in the morning after an anxious dream (269). in the evening before going to bed (270); especially on simoling (as usual) (273); early each morning after getting up (281). in the evening (282). immediately after midnight (276). after eating, though he relished it (279); without having eat anything (283); in the morning (284)........................ 6 A.M. (286). 64 RULES FOR THE STUDY OF Squeamish and sick (287) "VOMITING of MUCUS (288) CHOKING RISING of water and MUCUS, like water-brash; there was a rising up his chesthe was quite cold during the time in the body (289) Painful feeling, as of CONSTRICTION (290) A sort of belching of mucus (291) (Cough (292); compare under larynx and windpipe.) HEADACHE (293) Cutting, as with knives (295) Pressive ache (296) At last pressure till it is unbearable Stomach-ache (297) Ache, making one illtempered (208, 299, 300); like a stone (298) Pinching (301) Feeling of BEING SWOLLEN (302, 303) Constrictive pain 309, 310) Cutting, with eructations, flushes of heat, nausea and vomiting, merely of the ingesta (310) after drink (afternoon) (287). in the evening............................... in the evening. in the lower part of the oesophagus. from the stomach in the region of the epigastrium. in the epigastrium on the bladder and perinoeum. in the stomach in the epigastrium. in the epigastrium. of the stomach (309) in and above the epigastrium. in the morning (291). especially after eating (292). quarter of an hour after each meal, gradually disappearing, but renewed by each meal (293). on walking immediately after supper. it goes away on sitting. both during and after eating. after eating, while walking. some hours after eating (309). PHARMACODYNAMICS. 65 Conclusions. When we include with these the above given mouth; symptoms and thefever symptoms, the forms of disease, here excellently portrayed, become easily fixed. We find, directly, 1) an affection of the mucous membranes, presenting itself as inflammation (compare the cutting) occasioned by acid in the stomach, and probably dependent on venous congestion here first conspicuous; (compare the morbid hunger, the cravings, eructations, aching, pinching, flushes of heat (310), aggravation by eating, drinking, smoking, walking; particular mental states (298). This action on the venous system becomes still more manifest through 2) the morbid excitement of the bilious secretion, the bilious element, (bitter taste, eructation, yellowish-green vomiting, bilious vomiting). Probably these conditions (venous congestion) also occasion 3) the affection of the ganglionic nerves, which we see here sketched. How far 4) 5) the liver and spleen, and 6) febrile conditions here take a part, will only later be seen. According to the insight into the Bryony action thus obtained, the following forms of disease here present themselves. A.-SToMACH AFFECTIONS (HYPEIREMIE). (1.) Congestions (of venous character) presenting themselves, as cardialgia, (with congestions to the head) especially of drunkards, (saliva symptoms, see above, vomiting, pains,) of pregnancy (longings 248, 249). (2.) Catarrh of the stomach, commonly called gastric affections, as vomiting; acids; dyspepsia. (3.) Inflammation of the stomach, rather the venous; chronic (261, 262, 295, 309, 310). Remark.-Trinks refers S. 290 to contraction of the orifice of the stomach. B.-BILIOUs STATES. Compare further on, Abdomen-symptoms for liver-and spleen-affections. F PHARMACODYNAMICS. 67 - Tensive pain (314) Burning pain (315) PAIN, AS IF ABOUT TO VOMIT (316) Pain, like stitches in the spleen At first tearing and drawing Then shoots (318) in the region of the liver. in the abdomen, in the region of the liver. in the abdomen. on both sides of the abdomen. in the abdomen............................... particularly on movement. especially during stool and chiefly in the evening. after drinking a warm cup of milk in the afternoon. and disappeared after stool. Violent cutting stitches (319) The pain compelled him TO BEND DOUBLE (319) Griping, with shoots (320) BELLY-ACHE, with anxiety and dyspnoea (321) Flatus does not pass without loud rumbling noise (322) FLATULENT COLIC, (323) with pressure Pain, as if he were PURGED, or as if the piles were about to come on (324) CRAMPISH pains (325) Pressure, as from a knob (329) As if a lump lay (330) from the abdomen upwards to the stomach I.."......................... about the navel............................ relieved by walking. in the region of the coecum. in the abdomen. in the abdomen. on the navel deep in the abdomen. in the night. after supper. on walking out. Conclusions. The proportionally small number of these symptoms nevertheless includes a number of forms of disease, since those of the stomach treated together with those of the intestinal canal, and the stool-symptoms that follow, with those of fever, must F2 68 RULES FOR THE STUDY OF be counted with them. The idea included under the word "abdomen" is also a very comprehensive one. In agreement with the already explained Bryony character, we here give: A.-DISEASES Or THE INTESTINAL CANAL. (a.) Its mucous membrane. Hypersemia; congestive and inflammatory affections; (compare the fever symptoms, mucous and bilious fever; typhus). (b.) Its serous and fibrous membranes, (compare the cerebral symptoms)., Hyperoemia; peritonitis serosa, S. 304, 311, with disposition to effusion, (compare dropsy) consequently and especially in peritonitis puerperalis, (compare what follows under the relations of Bryony to childbed, and to the female sex.) Abnormal sanguification; hydropic exudation, after acute states, as a sequela of scarlatina. Rheumatism; peritonitis muscularis. c. Neuralgia. Enterodynia; colic (294, 305-308, 316, 321-323, 325, 329, 330). Compare chill, effect of flatulence, inflammation, (319, 320). Remark.-In connection with the stomach and anus there are indications for ileus. B.-DISEASES OF THE LIVER AND SPLEEN. Congestion, probably rather of the venous character, and inflammation in the second stage; sub-inflammatory states; affection of the serous envelope. The symptoms are not characteristic enough of the higher degrees of inflammation. (The Vienna provings have more decided liver symptoms.) Remark.-Many symptoms of the mouth and stomach become here comprehensible. Also those of the hepatic secretion, and the chemical constitution of the gastric juice. Also many symptoms of cardialgia, which often appear only as consequences of congestion to the liver and spleen. rHARMACODYNAMICS. 69 Compare further on. Stool and fever symptoms for the affection of the intestinal canal -== affection of mucous membrane. Symptoms of the extremities for rheumatic nature = affections of the fibrous membranes. Above, compare cerebral S symptoms for affection of the serous membranes; exudations, mouth and stomach symptoms for gastric and bilious character. ANUS. (STOOL.) RUMBLING in the ABDOMEN, BELLY-ACHE, and feeling of approaching diarrhoea (326, 327). Horrible cuttings in the abdomen, as if DYSENTERY was coming on, without any evacuation (328) Twisting and pinching, as if after a chill, and after the pain a LARGE SOFT STOOL (331) Very offensive frequent evacuations (332, 338) and cutting before-hand (332) DISTENSION OF THE ABDOMEN, working in the bowels, cutting, and then continual COSTIVENESS; he feels as if something lay in the bowels (333). Pain in the abdomen, as of constriction and contortion (334). It excites an evacuation (335). Stool twice a-day, after some days constipation (336)........ o............... in the abdomen and region of the navel. in the abdomen. in the forenoon. 70 RULES FOR THE STUDY OF Brown, frequent soft stoolin a suckling (337). Stool of large diameter, PASSED WITH DIFFICULTY (339). DIARRHOEA (340,341, 345, 347, 353, 355) preceded by griping (349). Looseness, without any other complaint (342); with burning (353) Diarrhoea, four days consecutively, every three hours, so urgent that he cannot help passing the stool; the twelve days following the usual stool almost as urgent, passed unexpectedly (343). Diarrhoea twice aday, so debilitating as to keep him in bed (344). Diarrhoea, with a strong smell of putrid cheese (347). Soft BLOODY stools (348)..After a hard stool long continued burning (350) Very firm stool, with forcing out............... which however soon reentered; after which diarrhoea with borborygmi (351) Large itching, jerking stitches (354) in the morning in general (345), particularly at night (346, 353). in the rectum. of the rectum. in the abdomen. from the anus upwards. Conclusions. The actions pictured here are partly completions of what PH-ARMACODYNAMICS. 71 has passed before, partly open up new states, which, however, depend essentially on known relations. 1. The fits of colic, S. 326, 327, 331-334, 349, (cutting) - establish the relations of Bryony to the chill element, to the mucous and sero-fibrous membranes, (consequently catarrh, rheumatism) but stand in connection also with affection of the liver and the hepatic secretion. 2. Dysentery is obviously occasioned S. 228, 346-348, 353, by the catarrhal hypercemia of the mucous coat, a special predilection for the intestinal portion of which we have recognised as proper to Bryony. The relationship of this affection with typhus and cholera, allows us to conclude on its activity in 3. Typhous diarrhoea when the other fever symptoms 4. Cholera indicate Bryony. 5. In several symptoms diarrhoea alternates with costiveness 336, 351, or constipation alone recurs, 338, 350, 352. In order to find out from this alternation the points for determination, we must interrogate clinical experience. This teaches us that Bryony acts especially in constipation. In agreement with this, the Vienna proving shows that constipation is the essential action of Bryony, and that diarrhoea occurs only after large doses. (This speaks strongly as to the meagreness of Hahnemann's proving). How this action consists with the general character of Bryony, it is difficult to say. However, bile seems to play the principal part, to which the colour of the diarrhoea, the connection of the Bryony obstruction with liver affections, (after sedentary mode of life, indulgence in alcoholic liquor, &c.,) may incline us. The bilious element in Bryony (compare also the yellow colour of the skin) has also here, consequently, its circle of action. The connection of obstruction with congestions to the head, and with heemorrhoidal affections (354), may also give indications for the choice of Bryony. If we now connect the above-named forms, here again in regard to the seat come out predominantly PHARMACODYNAMICS. 73 TARILY; on inspect there is none (364). Some drqps of urine PASS INVOLUN' RILY (365) After micturiti feeling as if he had quite finished, and so drops pass involun rily (366). URGENT DESIRE micturate and frequ MICTURITION (367) ion hot TA-.......................... on m ovem ent. ion, not )me itato Lent.............................. on walking out. THE GENITAL SYSTEM. (A.)-The Male. Itching, burning and in the ant. part of shooting (368) - urethra Burning (369), and aching (379) in the urethra. Drawing and tearing in the ant. part of (371) urethra (371) the the when not making water (368). when not making water. while sitting. Some stiches (372) Shooting, burning, itching (373): Several red itching MILIARY PIMPLES (374) in the testicles (372) on the border of the prepuce. on the glans. (B.)-The Female. of the labia majora. SWELLING On which a hard black PUSTULE arises, like a small lump, without pain and without inflammation (375). Very distended abdomen, with general restlessness and pinching, AS ON THE APPROACH OF THE MENSES (376). THE MENSES COME TOO EARLY, 8 days (377); 14 days (378); 3 weeks (379). 76 RULES FOR THE STUDY OF element is here manifestly confirmed by the coryza symptoms. As S. 392 and S. 395 show the head symptoms are especially indicative of the Bryony-coryza, and likewise the general character of the medicine as it makes itself manifest, in fever (S. 390), in rheumatic and catarrhal processes. The states immediately following are frequently not to be distinguished from those laid down in this section. LARYNX AND TRACHEA. Some HOARSENESS, (385, 386, 388), only one tone of voice, with inclination to sweat (386) Voice rough and hoarse (387). VISCID MUCUS, detached by hawking (396) DRY COUGH (397), as if from the stomach (398), preceded byitching and tickling (398) Cough, from a continual tickling Afterwards expectoration of mucus (399). COUGH WITH EXPECTORATION (400, 401) at the same time (400) Continued dry cough with running of water out of the mouth like water-brash (402). Nausea, irritates him to cough (403). On coughing vomiting of food (404). On coughing a long continued shoot (405) Dry, short, hacking tussiculation, several.............................. whilewalking out (385) in the fauces, in the trachea (40). at the epigastrium. in the throat in the forenoon. especially in the morning. deep in the brain on the left side. against the upper part of the windpipe. PHARMACODYNAMICS. 77 spasmodic forcible shocks, which seems to be covered with dry hard mucus (406) Irritation to hawk (407), as if some mucus After hawking for some time, a pain, compounded of excoriation and ache A feeling which compels him to cough, as if from vapour He feels AS IF HE COULD NOT BREATHE AIR ENOUGH (408). Violent cough, with much EXPECTORATION OF MUCUS for a quarter of an hour (410) Scraping painful tussiculation, as from ROUGHNESS and DRYNESS He coughs up clotted pieces of BLOOD (414). He hacks and hawks YELLOW MUCUS out of the fauces (415) On coughing shoots (416) were in the windpipe. in the trachea, in the trachea, excited smoke. by tobacco more violent on speaking and smoking. on coming from the open air into a warm room. in the morning in bed. at the top of the wind- in the evening after lying pipe (412) down in bed (412). inwardly in the throat. Conclusions. We need after the previous explanations only a short classification here, in order to understand the action of Bryony on the parts under consideration. But several of the chest symptoms that follow, necessarily at the same time belong here in order to complete the picture. I.-HYPERIEMIA OF THE MUCOUS MEMBRANE OF THE WINDPIPE and of the LARYNX. (1.) Simple acute catarrh after a chill, or in connection with other states, see Skin Diseases. 78 RULES FOR THE STUDY OF (2.) Febrile catarrh, influenza with the accompanying headache (405), nervous cerebral irritation, gastric affections (398, 402, 404,), pains in the back, &c., to which the general Bryony type is very suitable. (3.) Acute and chronic bronchitis and laryngitis, especially the period of transition from one to the other, (hoarseness, dryness, viscidity, incipient looseness of the expectoration, excoriation, ache, scraping, shooting). (4.) Chronic catarrh (dry, hacking tussiculation, tightness of the chest, excitability from tobacco smoke, speaking, changing the air,) of old people, with emphysema, bronchiectases, after hoemoptoic infiltration, after pneumonia (obstruction of the air cells). (5.) Hemoptysis (414) explainable from its action on the lungs and its venous relation, consequently in tuberculosis, but also in abdominal venosity, catamenial irregularities (compare menorrhagia, epistaxis). II.-NEUROSES (of the larynx). (1.) Spasmodic cough, nervous form (398, 399, 406, 408, 412). (2.) Whooping cough with inflammatory irritation of the chest (see these symptoms). (3.) Sympathetic affection of the vagus (cough with vomiting). Compare further on, chest, fever and skin symptoms; above, head, stomach, abdomen, genital symptoms. Remark.-The cough symptomzs are more clear in Hahnemann's than in the Vienna provings. CHEST. (Organs of Respiration, the Macmmce, the Heart) On COUGHING, stitch- in the short ribs. es (417) On COUGHING, a shoot in the sternum. He must hold the chest with his hand; it shoots also (418).......................... on feeling the parts. On coughing, SNEEZING twice (419). P'HARMACODYNAMICS. 79 On coughing, a heaving of the stomach to vomit, without nausea (420). On coughing, pain of soreness (421) On coughing, it strikes through the whole head (422, 423), like an ache (423). Immediately after a fit of coughing fr-equent GASPING FOR AIR, quick SPASMODIC INSPIRATIONS, as if the child could not recover his breath, and therefore could not cough; a sort of FIT OF SUFFOCATION, whereupon cough follows (424). A pressing ache squeezing the chest (425) An extraordinary HEAT SHORTENS the breath, with a sort of aching pain (426) Burning pain (427) The breathing is intercepted, (428), short, he must breathe quickly (429). Tightness of the chest (430). For twelve hours a fit of TIGHTNESS OF THE CHEST and shoots in the side (431). Tightness of the chest; desire to draw a full breath,- as if obstructed in the chest and prevented from breathing > pain, as if at the epigastrium. especially after midnight. at the pit of the stomach. in the epigastric region (426). in the right chest. 80 RULES FOR THE STUDY OF something was stretched which resisted extension (432) Anxiety in the morning, as if from the abdomen, as after a purgative, and as if the breath was too short (433). BREATHING QUICK, ANXIOUS, ALMOST IMPRACTICABLE, on account of shoots, then stitches in the vettex (434) Pressive pain (435) Pressure as if with the hand (436) With the feet as cold as ice, a pressive pain (437) As if it were obstructed with MUCUS, a pressive pain (438) and some shoots (438) With weight in the body, WEIGHT (439) Shoots every now and then (440) A shoot (441) A tensive pain, increasing to a dull shoot (442) Shooting, with anxiety (443) in the chest, first under the shoulder blades, then under the pectoral muscles, over the whole chest. on the upper part of the sternum, on drawing afull breath. which prevent respiration, and oblige him to sit up. she believes she cannot go into the open air without pain. in the middle of ti sternum, on the chest. in the sternum (438) on the chest, he on inspiration. on inspiration, which appears to lessen after eating. which disappears on eating. on drawing afull breath, in the side, on the ribs disappearing in the open air. from the upper part of the chest through to the shoulder-blade, at the posterior part of the ribs, especially under the shoulder-blades in the chest, on inspiration. on inspiration. on drawing a deeper breath, and chiefly on stooping forward. in the evening. PHARMACODYNAMICS. 81 A momentary shoot to which succeeded simple pain (444) On the side of the chest, on which he did not lie, a stitch (445) Shooting and throbbing, like a pulse (446) A shooting pressure from within outwards (447) A shoot, ulcer (448) as in an PAIN, AS AT AN ECCHYMOSED PART (449) Pain, with oppression, disappearing on * discharging flatus An attack, as if the disease had come to a height and TOOK AWAY THE BREATH AND SPEECH (451). A pain, as of being squeezedtogether (452) A squeezing chestpain (453) INWARD HEAT IN THE CHEST (455, 456), and in the face (456); sensation AS IF ALL WERE LOOSE IN THE CHEST and fell downwardsinto the abdomen (457). A squeezing pressure (458) Considerable SWELLING (459) in the left collar-bone...4.9. 0.................... in the lower part of the right side of the chest. in the chest. on a small spot under the sternum, which pains like an ulcer, at the ensiform cartilage, over the whole chest, of the chest near the sternum. exactly ever the epigastrium, behind the sternum, of the external chest in front. on turning in bed. on the slightest inspiration, as long as it lasts, even under the touch, but still more on raising the right arm; in the morning (448). under the touch, in the evening. in the evening (9 o'clock) (450). at its worst when sitting on a chair and stooping, and while lying on the side. more violent on inspiration and expiration. 84 RULES FOR THE STUDY OF the serous membranes for the formation of exudations (effusions). Compare, therefore, the pressure, oppression, the peculiar tightness of the chest, the undefined dull feeling and the sort of cough (as above); further, S. 432, 442, 447. From these we conclude again upon the plastic processes in the brain and the abdomen. III.-ABNORMAL SANGUIFICATION. (1.) Serous effusion in the cavity of the chest, hydrothorax in consequence of pleurisy. (Compare many symptoms of tightness in breathing, pressure, especially S. 432, 433, 439, 442, 457, 463.) (2.) As a consequence of organic changes, - Asthma occasioned by tuberculosis. (Compare the symptom of obstruction of the air cells-cough,) in connection with hydrothorax or hcemoptoic infiltration, as a consequence of inflammations (exudations) on the pleura, in the pulmonary tissue, heart affections with venous disturbance of the circulation (452, 455-457), probably also in compression of the cavity of the chest by ascites (433, 450, 451). IV.-NEUROSES. S. 454 contains a confirmation of the above given whooping cough action. Remark.-Many symptoms in this section complete the catarrhal states given above-also influenza, hcemoptysis. B.-MAMMARY GLANDS. The relations of Bryony to the glands and to the female sex evince themselves in the form of mastitis. The phenomena in the nerves, muscles, and integuments, the back and head pains point this way. Consequently when not nursing, as well as when similar affections occur as a consequence of suckling, or on weaning. C.-T, E THEART. The symptoms of the organs of respiration must be included in order to complete the very defective indications PHARMACODYNAMICS. 85 of heart disease given here. The symptoms are hardly important enough either for organic affections,- or inflammations of the heart; yet we may conclude upon venous congestions in the cardiac circulation, and on exudation in the pericardium, partly through the secondary action on the pulmonary circulation, partly through comparisons with cognate states. Compare further on, fever and limb symptoms; above, larynx, trachea, head, stomach, abdomen symptoms. Painful STIFFNESS OF THE MUSCLES (464) PAIN and WEAKNESS, as if the head were too weak (465) PAIN, AS IF AFTER A CMILL (466) Pressing pain (467) Burning (468) Painful pressure A dull shooting (469) A CRAMPISH PAIN, almost like a shudder (470) Shooting (471) Shooting pain for six hours (472) Pain (473) Burning (474) A contractive pain, almost like a cramp, as if he were bound together with bands (475) BACK. on the right side of the nape of the neck to the axilla, on the nape of the neck where it joins the occiput. in the nape of the neck. between each scapulme, and across to the front of the chest, under and between the scapulae. on the right acromion, towards the posterior and external parts, extending to the shoulder joint, between the shoulder blades. in the lumbar vertebras. in the loins and back, in the loins, in the back. across the whole back, on moving the head. while sitting, discappearing on walking. more violent on touch. on a deep inspiration. at night. which very much impedes walking. in the afternoon, from 4 - 8 o'clock in the evening. 86 RULES FOR THE STUDY OF Drawing (476) down the back, A painfully shooting near the spine, plucking (477) on both sides, Pain of bruize (478) in the sacrum, Tearing (479) Two great shoots, as from a knife (480) A tickling, creeping, as of a mouse (481) in the back and I vertebrea, in the hip. from the axilla hip. numn on sitting, going away on movement. while sitting, especially morning and evening (477). while sitting, worst when lying, slight when moving. bar more in standing than in sitting, but not in lying; it prevents bending and stooping. the to Conclusions. With the intermixture of the different seats of the affections, that of the latter proceeds hand in hand. We distinguish therefore,I.-Hyperoemia (A) of the vessels of the spine. (1.) Venous congestion as a concomitant of catamenial and heemorrhoidal affections, from a sedentary mode of life, with obstructions (compare stool). As evidences of this, pressure, burning, shooting, shooting jerks: the seat,-the skin, muscles, vertebrae. Aggravation by touch, and in the evening. II.-NEUROSES (B) OF THE SPINAL MARROW, probably depending also on congestion, or at least in connection with I. This gives us,(1.) Spinal irritation (hysteria) and its consequences. (2.) A portion of fever symptoms (intermittent and nervous fever). For this nervous nature speak S. 465, 467, 470, 475--478, 481, (weakness, pressure, cramp, spasms, drawing, jerking, pain of bruise, tickling, creeping). Amelioration by movement. PHARMACODYNAMICS. 87 III.-RHEUMATISM (C) OF THE MUSCLES, TENDONS, LIGAMENTS, VERTEBRAE. (Compare the symptoms of fever, and those of the extremities.) Here, the extension of the pain, which appears as stiffness, either drawing or tearing, as after, a chill (466) becomes manifest, and does not bear movement well. Remark.-The back pains are often only secondary and sympathetic, being connected with the abdomen and chest troubles, tearing in the extremities, (thus S. 469, with pleuritis mnuscularis.) They frequently, however, occasion as primary, (spinal irritation) other states, as bladder affections, colic, crampish pains of pregnancy. Compare further on. Symptoms of extremities and of fever. Above: abdomen, stool, genital and chest symptoms. EXTREMITIES. A dull shoot (482) SWEAT (488) A sort of shoot (483) A quivering and jerking (484) Drawing, as of- a thread (485) Pressing pain (486) NERVOUS tearing (487) Pain, as of sprain (489) Shoots (491) SWELLING (490, 492) (Upper and Lower.) above the axilla down to the arm. in the axilla. in the upper arm, in the deltoid muscle. through the arm bones down to the finger points. on the bones of both upper arms, down the inside of the arm. in the region of the acromion, in the right elbow joint. of the right upper arm to the elbow (490); on the elbow joint and a little above and below to the middle of the upper and fore arm, as well as on the under part of the foot (492). especially on lifting it. which prevents sleep in the evening. on lifting up the arm. RULES FOR THE STUDY OF Tearing pain (493) Red MILIARY ERUPTION (494) Violent shooting and creeping (495) Shooting With drawing (496) Creeping, as if numb (497) Shooting pains, with WEIGHT (498) HE CANNOT GRASP FIRMLY TREMBLING AND DISTENDED VESSELS (500) Pain, as if SPRAINED or DISLOCATED (501) Fine shoots (502) An INFLAMMATION with burning pain (503) Feeling of HEAT, after some hours feeling of COLD (504) STIFFNESS and feeling of NUMBNESS (505) Tearing for a short time, recurring at intervals (506) Involuntary twitching (507) Shooting pains (508) NUMBNESS (509) PARALYTIC FEELING (510) on the inner surface of the fore arm from the elbow in a line to the wrist. on the upper side of the fore arm. in the left arm. in the point of the elbow. in the tendons down to the hand, in the hand. in the wrist. with the hands (499). of the hands. in the wrist, in the root of the hand, of the back of the hand (about midnight). in the palm of the hand and the fore arm, in the palm of the hand. in the joint between the metacarpus and the fingers, or in the last finger joint. of the fingers of both hands, in the fingers, of the fingers of both hands up to the root of the hand. in the fingers. on bending the elbow the shoots are worse. on each movement. when the hand is warnz and at rest, it also does not go away on movement. she must put it out of bed in the morning. on mo ving. on writing. PHARIMACODYNAMICS. 89 Pain, as of shooting and cramp (511) Hot, pale SWELLING, with shooting pain (512) A pimple, which causes a fine shoot (513) Pain, as if PUS WERE IN IT (514) Pain, as of bruise (515, 517) A pain every now and then, like a cramp (516) Pain, as shocks or blows (518) Shooting pain (519) Frightful shooting pain, with throbbing (520) UNSTEADINESS (521) and TOTTERING (521, 526) Dull shooting pain (522) Itching (523) Tearing pains (525) Great WEAKNESS 525, 527, 533) Drawing, AS IF THE MENSES WERE COMING ON (528) Stiffness, like cramp (529A*) A shoot (529B) in the ball of the thumb. of the last joint of the little finger, between the right thumb and index fin on moving the finger and making pressure on it. on each touch. ger, at the root of the little finger. of the loins and the thigh, in the loins. in the hip joint, from the hip joint to the knee, in the trochanter therein, on lying on it. while sitting and lying. whilst lying or sitting, better on walking. on walking bent for ward. on a false step during rest; on touch the place feels sore. in the thigh and leg. in the hips. on the hips and thigh. in the right thigh, in the thigh and feet, in the thighs. of the thigh, on walking up or down stairs (526). on movement. can hardly go up stairs (525, 533),less on going down stairs (525), to be felt even when sitting (527). in the morning in bed. in the upper and anterior portion of the thigh. * Hahnemann has miscounted here. 90 RULES FOR THE STUDY OF Pain, as of a bruise, and beating, as a hammer (530) Cramp (531) Pain, as of fracture (532) Tense painful STIFFNESS (534) A painful and shooting PUSTULE (535) Tearing and burning (536) Pain, as of having been beat (537) SWEAT and itching, as when an ulcer is healing (538) Fine, passing stitches (539, 540) DRY RASH, which itches, looks red, and smarts after scratching (541) Weakness (542, 543) TOTTERING and KNOCKING (544) So weak are the that they hardly support him (545) Sudden SWELLING (546, 554) without redness (548) pain, as of bruise And NUMB-FEELING (547) With SWEAT afterwards (549), violent drawing pain (549, 550) RASH exuding moisture (551) in the middle of the | while sitting, thigh, in the knee and the sole, in the patella, in the knee. under the knee, in the right knee. in the patella. while sitting and night on lying. on going down stairs. merely on touch. in the ham, at night. in the knees (539); in on walking (539), merethe knee joint (540), ly on movement (540). on and in the ham, especially in the knee joint. of the knees, legs, in the evening. in walking. on beginning to walk, and merely on standing. on moving, turning, or feeling the foot. during rest. of both legs (546, 554), of the under half, with the exception of the feet (549). on the outer side of the left calf, at the same spot, in the leg, especially the calf; in the bones of the legs (550). on the legs. 92 RULES FOR THE STUDY OF Pain, as if torpid, and like tension (576) Feeling of weight; numbness, as if swollen (577) Shooting and pressing pain, with pain as if frozen (578) A hitherto painless corn aches and pains (579), as if sore with burning and shooting (580, 583) Shooting pain (581) A shooting, with strong feeling of heat (582) Pain, as of bruise (584, 585) Pain, as if bruisedor as if ulcerated un.. derneath (586) Pain, as if the flesh were loose (587) A painless drawing to and fro (589) An anxious, pressive drawing pain, as on the approach of an intermittent fever (590) Pressing pain (591) Violent drawing (592) It is intolerable to him to keep the affected part still (593). Visible jerking (594) When the pain subsides, coldness of the in the depth of the sole. in the under part of the foot. in the toe. ball of the great in the balls of the right toes, in the balls of the toes of both feet, on the ball of the left toe. the arms and legs (585), every part of the body (586), all the limbs (588), especially in the epigastrium, over the whole body. in the affected parts. in the periosteum of all the bones, over the whole body, especially on the chest. through all the limb-s. in the arms and legs, worse on walking, but also during rest (579), on the slightest touch (580; 583), even in bed (580), thezpain ceases on strong pressure (583). more on sitting, less on walking. towards evening. even in lying, while sitting, worse than when walking; he mustcontinually change his position (585), on grasping any thing (586). in the forenoon. during the day while sitting. PHARMACODYNAMICS. 93 face and trembling (595). Like needles running into one (597); shoots (596, 597) Suddenly a shooting itching burning, as if stung with nettles (598) Nothing to be seen on the skin; this burn ing (598) Continual burning, itching, stinging (599) Frightful shoots (600, 601, 602) Painful throbbing (603) in the affected parts. over the whole body, on a slight emotional excitement (laughing). came on the mere thought, or on being heated. evening, after lying down in bed. on movement, on touch, (600), pressure (602). over different parts of the body, in the joints (600), in the affected parts (601), in the vessels over the whole body. Conclusions. Besides some undefined statements (as thigh, back of foot, &c.,) we find, however, also very definite indications to affections of the muscles, ligaments, tendons, periosteum, particularly also of the joints (membranes ligaments), as well as of the skin and cellular membrane. The relation to the fibrous parts is predominant, which we shall turn to account in the employment of the clinical forms. A.-Independent Diseases. The already often indicated rheumatic nature of the Bryony affection very prominently comes out, either with or without fever, as,I.-ACUTE AND CHRONIC RHEUMATISM are clearly expressed in S. 485-487, 490, 492, 493, 498, 506, 509, 510, 516, 518, 524, 530-32, 534, 536, 546-50, 552, 554, 556-60, 564, 566, 567, 570, 571-76, 585, 587-90, 593, 596, 599, and manifest the relations of Bryony to the chill element. (Compare also the pains, drawing, jerking, tearing, cramp, creeping, shocks and blows, pain as of bruise, as if the flesh were beat loose, as 94 RULES FOR THE STUDY OF well as the aggravation by movement, touch, at evening and night). The especial forms are here,(1.) Muscular rheumatism, articular rheumatism (with gastric complication, with pericarditis, endocarditis). (2.) Lumbago rheumatica (S. 519). (3.) Ischias. From these rheumatic phenomena we conclude back again on the head pains, the prosopalgias, the tooth-ache, the colic, the nature of the pleurisy, &c. II.-Gout, which is to be concluded from the inflammatory nature of the Bryony affection, the chill elements, the affected parts, especially the relation to venosity, the complication with fever and gastric states. The action on the sanguification explains also the tendency to exudation. With this view compare S. 482, 483, 491, 495, 496, 498, 499, 502, 503, 505, 506, 508-12, 514, 519, 522, 524, 529 B, 532, 534-40, 542, 543, 550, 552, 558, 561-76, 578, 581, 582, 584, 590, 593, 595, 596, 599, 600-602. The forms are,(1.) Arthritis acuta, with disposition to effusion, to deposition, swelling, especially that of the great toe. (2.) Arthritis (articulorum) with lymphatic effusions into the capsules, inflammation of the periosteum, of the cellular membrane. III--HYPERJEMIA. (Compare the pain of sprain, of ulceration, the ache, the pressing pain, burning, tension, especially shooting, (thirty-one times), aggravation by movement, touch, at evening and at night.) According to the parts affected, besides the gouty element, external agencies, such as sprains, strains are especially here the causes of mischief. We have here,(1.) Inflammation of the muscular fibre (psoitis S. 524, 529). 1. stage. PHARMACODYNAMICS. 95 (2.) Inflammation of the joints, 1. stage of coxalgia (520, 522), after sprains, violent movements. (3.) Inflammations (of the skin and the cellular membrane) from pressure, cold, &c., (578). (4.) Phlebitis, in the form of Phlegmasia alba dolens, during the puerperal state (529, 530). B.-Next to these independent forms the symptomatic states now occur, which however likewise lie in the character of the medicine. (1.) Congestive phenomena dependent on congestive states of the spinal marrow, connected with spinal irritation, partly in neurosis (S. 484, 495, 497, 500, 507, 509, 510, 515, 517, 521, 523, 526, 528, 529a, 530, 531, 553, 555-557, 569, 577, 587, 588, 594, 598, 603), partly in fevers (S. 504, 507, 509, 510, 515, 517, 525, 526, 527, 533, 537, 542, 545, 585, 586, 588, 590, 591, 592, 594, 603). (2.) Symptoms of the sanguification. (a.) As the secretion of the lymphatic fluid (oedema), (S. 490, 492, 546, 554, 558, 565, 577), especially in acute anasarca after scarlatina. (b.) As exanthemata (494, 513, 523, 541, 551). (3.) Venous phenomena, dependent on abdominal anomalies, as haemorrhoidal states, and menstrual affections. Compare further on. Febrile states, skin. Above: head, face, toothaches, abdomen, chest and back symptoms, &c., for the rheumatic and hyperaemic character. Abdomen and back symptoms for the venous character. Stomach and intestinal canal for the gastric complications. Affections of the serous and fibrous tissues for the exudations. 96 RULES FOR THE STUDY OF Scabious (604) eruption THE SKIN. merely on the joints, at the inner part of the wrist, in the elbow joint, also outwardly on the olecranon prominence,in the knee, more than in the ham. on the arms, on the anterior part of the chest, and over the knees, on the abdomen and hips. Miliary rash becoming red, itching, and burning (605) Pimples, which burn and itch, On scratching, pain, as of excoriation (606) Yellowness (607) Both in mother and infant, and first in the latter, a red, elevated miliary rash (608) Eruption, which is painfully burning and smarting (609) Eruption so violently itching, that he is ready to scratch himself to pieces (610) Titillation and itch before she lies down; it goes off in bed. of the skin of the whole body, and particularly of the face. over the whole body. on the abdomen and on the back, even to the neck and the forearm, over the whole body, especially on the back up to the neck. on the legs, about the ing, knee, and on the thighs, After scratching and rubbing, SMALL, RED, ELEVATED PIMPLES, which burn; when the pimples are fully out all itching ceases (611). Tearing itching and on different places of routing itching burn- the soft parts of the ing shoots (612) body, With MILIARY PIM- on the arms, hands, PLES a tickling itching and feet, (613) before midnight and in the morning (painful). in the evening. just before going to sleep in the day or evening. (in the day). PHARMACODYNA.AMICS. 97 IED, ROUND SPOTS, not DISAPPEARING ON PRESSURE, LIKE LEN"TILS, without sensation and large (614) RED, SMALL SPOTS, On PRESSURE GOING AWAY FOR A MOMENT, pain like nettle-stings (615) A sore, painless place, begins to burn violently (616). Tearing pain in the ULCERS (617). The ichor from the ulcers colours the linen black (618). Smarting pain (620) The ulcer feels cold and is painful, as if it had come in contact with very cold air (619). Throbbing almost like stitches (621) in the skin of the arms. in the skin of the arms and feet. in the neighbourhood of the crusts (of the ulcers). near the scab, in the morning after getting up, increased on standing, less on sitting, going off during moderate movement. after dinner. Conclusions. The exanthematic forms depend on the action of Bryony on the sanguification. Cutaneous eruptions are indeed frequently only products of decomposition and reflexes of more deeply-seated actions on the mass of the blood. The states which belong to this section are as follows: 1.-Miliaria, with its special affinity to the rheumatic process, to the serous and fibrous membranes, as an accompaniment of acute gout, of rheumatic fever, of pleurisy, and puerperal peritonitis. 2.-Purpura hemorrhagica in its connection with the 11 98 RULES FOR THE STUDY OF venosity and affections of the intestino-gastric mucous membrane. 3.-Erysipelas, especially the pseudo-erysipelas in inflammation of the joints, &c. 4.--Urticaria from rheumatic causes. 5.-iM easles. 6.-Scarlatina. 7.- Variola. In the three last forms more on account of the fever-symptoms, the cerebral appearances, the affections of the gastric mucous membrane, of the bronchia, of the lungs, &c. 8.-Jaundice as a consequence of bilious conditions, venosity, hepatic affections. Compare further on. Fever-symptoms. Above: almost all the other sections, external as well as internal. STATE OF THE STRENGTH. He does not like the open air, though he used to do so (622). Very ANXIOUS when in doors (623) General WEAKNESS (624, 625) (636, 637, 640) or WEAK, INDOLENT, PROSTRATE and SLEEPY (626) Aching (627) Want of stability, as if the muscles had lost their strength (628) Is weakest (629) Faintish and squeam-.. 0............................. in the extremities (625) of the arms and feet (627) in all parts of the body, better in the open air. in sitting, less when walking (637), which compels him to sit down (625), on lying down he appears better (638), on waking out of sleep (640). while working the arms sink; on going up stairs can hardly get on. on walking, especially on getting up from one's seat, and on the commencement of walking; after a while it gets better. in the open air. this disappeared in a 100 RULES FOR THE STUDY OF SLEEP AND THE STATES CONNECTED WITH IT. Soon after waking from his noonday sleep he is worse, all his morbid symptoms are aggravated, his feelings are perturbed (641). One night he sleeps sound till morning, and is SLEEPY the whole day after; the next night RESTLESS; the next day brisk (642). Fainting fits, with cold sweat and runbling in the abdomen (643) Very inclined to yawn, FREQUENT YAWNINýG (644, 645) constant, with much thirst (646) Stretching of the limbs (647) SLEEPINESS'(648,649, 650, 653); on waking all the limbs go to sleep (652) TIRED AND YET CANNOT SLEEP; when he is about to go to sleep he loses his breath (654). Tossing at night with hands and feet till one in the morning, as if anxious; he lies WITHOUT CONSCIOUSNESS, with cold sweat in the forehead, groans, and then weakness (655). Cannot lie in bed; on getting up out of bed. the whole day (644), before dinner (646).... (in the afternoon) (647). immediately after eating (648), also in the day (649), the whole day (651), when he is alone (653). PHARMACODYNAMICS. 101 any part he lies on feels sore (656). RESTLESSNESS IN THE SBLOOD, goes to sleep late anct not soundly (657). Tossing about, cannot go to sleep (658, 664, 668) for ANXIOUS H-EAT,Vand yet none is felt externally (658, 664), in the morning sleepiness (664). Sleeplessness from restlessness in the blood and anguish (659, 661, 663, 667), THE THOUGHTS CROWD ON ONE ANOTHER, without heat, sweat, or thirst (659) FEELING OF HEAT AND EXTERNAL HEAT, all over, without thirst, he lies on one side after another; on being uncovered immediately violent colic, pinching shooting, or shooting pinching, as if caused by flatulence spasmodically pressed here and there; sleeplessness frorn a number of ideas that crowd upon him (660) Cannot sleep for heat (662, 663); bed clothes too hot, on being uncovered too cool; without thirst, almost without sweat (662) Goes to sleep for the first time at 4 A.M. and he must rise (659); in the night (661); before midnight, (667). in the evening immediately on lying down, all night; it goes away in the morning without passing flatus............................... several nights. 102 RULES FOR THE STUDY OF dreams then of dead persons (665). Cannot go to sleep on account of A FREQUENT SHUDDERING FEELING OVER A FOOT OR AN ARM, then some sweat (668) After a short sleep, waking, there's a twisting about in the epigastrium, and a sickness as if to suffocate (669) WIMPERING in sleep (670) Before going to sleep and while. going to sleep JUMPING UP IN A FRIGHT (671, 672) so as to wake (673) out of a dream, and cries out (674) Awakes at night every hour and remembers a dream he has had; on going to sleep again remembers another dream as lively and as capable of being recalled on waking (675, 676), Very restless night; ANXIOUS DREAMS (677, 678), she cries out loud (677) He dreams while awake that some one wants to break the windows (679). RESTLESS SLEEP with CONFUSED DREAMS, tosses from one side to another (680). Restless sleep, full of thoughts (680).............................. before midnight. she must get up; in the evening. about 3 A.M............................... every evening (672). Sabout 3 A.M, PHARMACODYNAMICS.10 103 S OMNAMB3ULISTIC STATE (682), rises up in his dreams, goes to the door as if he would go out (687). INVOLUNTARY STOOL in SLEEP (683). Dreams full Of DISPUTE and VEXATIOUS THINGS (684).. Vivid dreams ABOUT ATTENDING TO HIS DAY1 S BUSINESS in an anxious and exactly correct manner, H-e busies himself in his dreams about his household affairs (686),.. He makes a movement with his mouth in his sleep as if he chewed (688). On waking from sleep he is DE LIRIOUS (689); nightly delirium (690). DELIRIOUS TALKING about business he has to attend to, going off on the accession of pain (691) The body being hot and covered with sweat (without thirst), a FRIGHTFUL IMAGINATION that soldiers are cutting him down so that he would escape from them, going off on uncovering himself and becoming cool (692) Drew her mouth to and fro, opened her eyes and distorted them, talked in delirium as if she had been.f........I the whole night. in the morning at daybreak. before midnight (about 2 A.M.). PHARMACODYNAMICS. 105 stance and of the membranes; ebriosity; compare the peculiar delirium S. 685, 686.). (2.) In febrile hypermemia of the spinal marrow, which extends itself to the brain, as is the case in inflammatory fever, rheumatic, gastric, exanthematic fever, and intermittents. (3.) In perturbations of the circulation in the heart and the lungs through congestion and inflammation. (4.) In inflammations of other organs. II.-IN ABNORMAL SANGUIFICATION, by which decomposition is introduced, and the activity of the brain is disturbed, as in typhus. The various deliria, their kind (S. 689, 690, 692, 693) point manifestly to a form of irritability which is proper to typhus, which especially occurs in the fist stage. In this transition stage Bryony will likewise find a place, as in the stage of inflammation, when the decomposition, the effusion begins. III.-IN NEUROSES. (1.) Many sensitive affections of the cerebral nerves, as we have learnt above to recognize them, produce as consequences the peculiar Bryony sleep-states. Wherefore, (2.) Spinal irritation with sympathetic action on the brain. IV.-In predominant venosity and abdominal states, in hepatic affections, gastric and bilious troubles (641), hnemorrhoidal and menstrual complaints, these appearances are indications for the choice of the remedy. Compare fever symptoms. Remanrks.-S. 643, 660, point to colic and spasmodic attacks; 654, 669, to states of the sleep in hydrothorax, asthma from diseases of the heart. S. 683, 697, belong to typus. From 682 and 687 Trinks concludes its employment in somnambulism. (?) 106 RULES FOR THE STUDY OF FEVER SYMPTOMS. In the afternoon SHUDDERING, then heat, at the same time with CHILLINESS; the chilliness (yet were the arms and hands warmer than usual), the heat was in With PULSE-LIKE THROBBING PAIN IN THE TEMPLES, (without thirst) (698). After the noon-day sleep he is chilly and confused in the head (699). He must drink frequently (700) DEADNESS AND NUMBNESS, ICY COLDNESS (703) Coldness (704) Chilliness (705, 706, 707, 711, 714); chilly feel (709, 710); much shuddering' (713) Violent SHIVERING as in an ague (708), with shooting pain in the left side above the hip, as if a gathering was forming there, though without thirst and without heat afterwards (708) A feeling of chilliness pervading a sudden general heat (716). Violent TI-RST (he must drink much cold in the chest and arms (698) the head (698). of the hands and feet. of the whole right side downwards. in the arms (706) all over, worse in the evening (698), in the morning on waking (701, 702). at nights. the whole day (706), towards evening (710), in the open air (707, 714), in the evening in bed (711), on lying down (712). compelling her to lie down. after a walk in the open air (715). over the (709) whole skin over the whole body, P HARMACODYNAMICS. 107 water) with inward heat, no heat to be felt externally (717). Great thirst (718), thirst without external heat (719). Feeling of heat in the face, with redness and thirst (720) Fugitive HEAT (721); heat (722). Heat in the external ear, afterwards shud-- dering and shivering (723) FEVER, lying down; CI-LLINESS, YAWNING, NAUSEA, then SWEAT, without thirst (724) Fever, in the forenoon, heat (with thirst) after some hours (in the afternoon) chilliness, without thirst, with redness in the face and undefined headache (725). Sudden dry heat at each noise (726) Heat in frequent fits, as if she stepped into hot water (727) Hot red cheeks, with shivering all over, goose skin, thirst (728) First thirst, then none, with cold feet and hands (729). In the evening she feels as if there was mucus in the throat, she gets thirsty (730). Violent (731) great (732,734) strong thirst, in the internal part of the body (especially in the abdomen) (722). in the legs (723) in the evening (723). from 10 P.M. to 10 A.M. (724).............................. and each (726). in the lower extremities (727). movement........................... in the evening (728). in the morning on getting up (734). PHARMACODYNAMICS. 109 SOUR SMELLING STRONG SWEAT during i a good sleep (762) 1i About 3 A.M. before sweat, thirst, then for four hours sweetish sweat smelling sour, before it goes off a pressive drawing HEAD ACHE, changing into CONFUSED IDEAS (763) Sudden awaking at " night at 3 A.M., gentle transpiration till morning with quiet repose on the back, little slumber, dryness of the anterior part of the mouth and of the lips, without thirst (764). Gentle transpiration in bed (with sleep from 12 to 3 A.M.) (765) DELIRIUM ABOUT BUSINESS (766), would several times jump out of bed (767)............................... in the night......................... after getting up. from evening till morning. Conclusions. a.-SYMPATHETIC FEVER. When we examine the nature of fever narrowly, we find it chiefly to be a reflex of a local affection on the central nervous system, and on the whole circulating fluid, and that fundamentally viewed it really represents in general what inflammation does specially and locally. The predominant venosity, the commencing decomposition and metamorphosis, which showed themselves in the forms and stages of inflammation proper to Bryony, as well as the character of irritability and sensibility therewith connected, occur quite in the same measure in the febrile phenomena of Bryony, which PHARMACODYNAMICS. 111 symptoms of the extremities) especially also in rheumatic-gastric fever with violent congestion. b.-IDIOPATHIC FEVERS. Besides these more symptomatic fevers, we can exhibit two kinds of fevers,-in which the central nervous system appears to be more originally affected,-intermittent fever and typhus, though it is still to be supposed that there are intermittent fevers in which the spinal irritation also depends only on local affections, as from affections of the spleen, the bladder, which affect intermittent states; and though further in typhus the disturbances possibly and probably depend rather on a corrupted and qualitatively abnormal circulating fluid. The phenomena of Bryony, however, all theoretical positions put aside, answer for an abundant activity of the medicine in both kinds of fever. I-IN INTERMITTENT FEVER. The type of intermittent fever is not so characteristically indicated, and the spinal affection comes too little into the foreground to fix Bryony for pure intermittent fever, at the same time the action of the medicine extends itself to organs, which may easily excite intermittent feverfor example, the spleen, the liver, the bladder, &c. It suits consequently in intermittent fevers, with pleuritic, venous, gastric, rheumatic phenomena, &c. Chilliness plays in them the chief part. II.-IN TYPHUS, especially in the stage of transition; with gastric, bilious, or pituitous characters; with complication of chest affections; in the versatile form, with increased sensibility (compare the symptoms of delirium, and sleep); from the absorption of irritating matter into the blood, as in milk fever, the commencement of pymemia, and the nervous phenomena occasioned by it. But in general we must not, in regard to the selection of Bryony, confine ourselves in all fevers to the febrile symptoms alone, as con RULES FOR THE STUDY OF sidered by themselves they possess no very high degree of significance; but we must consider the whole type of this medicine, which as regards fever, is completed by a comparison of the following symptoms:-of the head (congestive states), of the lips and parts adjoining (hidroa, aphthee), of the internal mouth (coating of the tongue, thirst, dryness, symptoms affecting the taste), of the stomach (appetite, eructations, and other gastric and bilious symptoms), of the intestines and their evacuations (we first learn to know the symptoms of gastro-enteritis and of puerperal peritonitis by taking together the febrile and local affections, as well as the characteristic constipation), the urinary affections (these become important for us only through the fever), the nasal and bronchial mucous membrane (the kind of cough is peculiarly characteristic), the chest (the complication of catarrhal and inflammatory affections with pleurisy, pneumonia is very distinctive for Bryony, and frequently occurs: for example, in typhus with the character of venosity, decomposition), of the heart (congestive states), of the back and the extremities (as well on account of rheumatic symptoms as of those of spinal irritation important in all fevers), of the skin (deciding the question for exanthematic fever, for miliaria compare the sweat symptoms), of the state of the strength and of sleep, which have only value in connection with the fevers, but exactly characterise the action of Bryony in certain defined cases. After an arrangement of. all these possible combinations, we are able to conceive of the variety in the kinds of fever in which Bryony is indicated. The hypermemic, nervous (congestive nervous), rheumatic and gastric character of the fever may be read from the foregoing fever symptoms themselves, without the need of any commentary or comparison. PHARMACODYNAMICS. 113 INTELLECT AND FEELINGS. Hesitations, APPREHENSIONS (768). ANXIETYin the whole body, which always drives him to something, and wherever he comes he finds no rest (769). ANXIETY; he is uneasy about the future (770). Very IRRITABLE FEELINGS, very disposed to FRIGHT, FEAR, and VEXATION (771). Very fretful and disposed to PASSION (772). At first DEPRESSION, then HILARITY (773). Depression (774). Much WEEPING (775). Feelings at once fretful, passionate, and tearful (776). Fretful, believes she will never be ready with her work, always takes the wrong thing up,WILL TAKE UP SOMETHING ELSE INSTEAD, then a pressive aching pain in the forehead (777). ILL HUMOURED, QUARRELSOME (778). MOROSE, looking on all with VEXATION(779). OVER-ACTIVITY, she will undertake and do too much (780). Excessive ill humour, indisposition to think, PROSTRATION of THE POWER OF THINKING (781). I 114 RULES FOR TRE STUDY OF Conclusions. The psychological truth of these psychical phenomena comes out from their agreement with the physical actions. 1.-S. 768, 769, 770, 774, 775, point to the connection with the venous states, especially of the abdomen, and clearly depict the melancholic temperament. 2.-The disturbances of the biliary secretion, the hepatic affections, the bilious-abdominal element, which are proper to Bryony, are completed by the derangements of feelings occurring in the choleric temperament. Compare S. 772, 776, 778, 779. 3.-A sensitive irritability connected with the nervous character is predominant- (S. 771, 773, 777, 780), which remarkably characterises the female sex and emotional life (hence Bryony in many diseases of women), but is moreover proper to certain forms of disease. PHARMACODYNAMICS. 115 FINAL RESULT. General characteristics of Bryony. When we combine the foregoing details in a general picture, the following general characteristic of the Bryony disease result. A. PHYSIOLOGICAL CHARACTER. The essential part of all the actions of Bryony is excitement of the vaso-motory actions. (2.) This appears predominant in the course of the venous system, and in the sphere of the capillary system, and more especially in its venous portion. (3.) This excitement of the vascular activity goes hand in hand in Bryony, with excitement of the nerves of sensation. It is possible that Bryony acts through direct change of the circulating fluid, or primarily on the nerves of sensation, and afterwards on the vasomotory nerves; but this excitement of the nerves of sensation will increase in either case secondarily with the exaltation of the vascular life. (4.) The increase of the circulatory movement appears as the first degree of the excitement of the vasomotory activity; the hyperaemia and congestion of the vessels especially the venous, (whether in consequence of contraction of the vaso-motory nerves set up by excitement of those of sensation? or primarily?) as the second; the action on the blood itself in inflammation, or in other metamorphic changes, as the third. Stasis with its reactions and terminations appears to be the most widely diffused element of the Bryony action, characterised by the affection of the venous syjstem (in contra-distinction to the arterial Aconite), by the sensational excitement, which occurs especially in connection with venous affections, and by the plastic tendency (in contra-distinction to the otherwise related Belladonna). That stasis often appears externally as accelerated circulatory 13 116 RULES FOR THE STUDY OF movement, and often succeeds it, is zoell known. Fever is only a general stasis. It is self-evident besides, that the foregoing three degrees are only ideal, i.e., do not manifest themselves openly as stages. II.-From this fundamental property the character of the reaction of Bryony is explainable. (1.) It is adapted specially for intermediate states and transition formations, partly as regards the participation of the nervous and vascular systems, partly as regards the transition from states of excitement to different forms of deposition. It is consequently suitable for erethistic states, in which a certain mobility of the blood (exalted irritability) with increased sensibility of the nervous system (exalted sensibility) is present; for such as are intermediate between synochal and venous states, or in the course of the disease for the period, at which a more pronounced synochal or erethistic character is passing into a nervous, connected with decomposition of blood. Consequently Bryony is adapted likewise for these stages of transition in fevers, which in inflammations begin at the second stage, at which transformation (effusion, &c.,) commences. (2.) Since we ~ind these wavering states of excitability also at the period of childhood, in the female sex in general, and quite specially during pregnancy and the puerperal state, in the melancholic and choleric temperament, in nervous bilious constitutions, states likewise closely connected with the venosity everywhere predominant, these individual physico-psychical states quite specially answer to Bryony. III.-On these fundamental relations a special light is thrown by(a) The pains which Bryony calls out, These are in the order of their frequency. PIARMACODYNAMICS. 117 1. Shoots (sharp, dull burning, burning-itching, tearing, cutting.............. S2. Pressing pain, (routing, pinching, squeezing) and their sub-species: Gradual pressure (compression, distension, pressure outwards) tension............ 3. Drawing (constriction) and the sub-species: Twitching, tearing (jerkwise twitching)............ = 4. Throbbing................. 5. Itching and its sub-species: pinching, smarting-creeping, scraping............ 6. Burning (shooting)........ 7. Squeezing pain.............. 8. Pinching (constrictive)......= 9. Pain of excoriation (cutting? smarting, ulcerative)... 10. Pain as of bruise............ 11. Pain as of sprain.......... = affection of the serous membranes -skin, glands: inflammation. affection of the vessels: congestion, inflammation, exanthemata, ulcers, exudations. affection of the nerves-specially the neuroses, the fibrous membranes: rheumatism-gout. affection of the vessels-congestion, &c. cutaneous affections-exanztemata -ulcers. affection of the mucous membranes, vascular tissues, external skin: congestion, catarrh, inflammation. affection of the nerves-muscles -fibrous membranes-neuroses -rheumatism-gout. affection of the nerves-muscles -neuroses. affection of the skin and mucous membranes-inflammation-exanthemata--exudations-ulcers. affection of muscles - nerves - fibrous membranes - bones: neuroses--'7eumatism. affection of bones:-rheumatisngout-(affections of joints). (b) Also the peculiar conditions, under which aggravation occurs, are characteristic. They are movement and pressure, (see hyper~mia), open air, (see catarrh, rheumatism, gout), the evening and night (see hypermia, vegetative states). These stand in connection as well with the morbid phenomena, as with the exciting causes (aetiology). 11F8 RULES FOR THE STUDY OF B. IETIOLOGY. All circumstances which excite the circulation will produce phenomena similar to those of Bryony, as vexation, anger, (venous-bilious states, hypercemia, fever), excessive exertions (diseases of the muscles, joints, hyperemia, fever); further, the exciting actions of the open air; chill, especially from dry cold and wind (rheumatism, catarrh), likewise whatever occasions obstructions of a venous character, a sedentary mode of life (plethora and its consequences). Consequently these exciting elements are also so far indications for the choice of Bryony. C. LOCAL RELATIONS OF THE BRYONIA DISEASE. (Anatomy.) Bryony has its special anatomico-physiological relations, (1.) To the venous and capillary system, and to the mass of the blood itself (compare stasis, metamorphosis, fever). This is the general action, and most of the following relations are only localised affections of the circulation and changes in the composition of the blood. (2.) To the peripheral but also central nervous system (brain, spinal marrow, spinal nerves, N. trigeminus ganglia)-(compare neuroses). (3.) To the serous membranes (pleura, peritonoeum, cerebral meninges, - (compare inflammation, exudations). (4.) To the muscles and fibrous membranes, (tendons, ligaments, neurilema, periosteum, especially the articular apparatus)-(compare rheumatism, gout, straining of the muscles). (5.) To the mucous membranes (mouth, stomach and 120 RULES FOR THE STUDY OF nerves (of the head, face, teeth, stomach-cardialgia, of the intestines-colic, of the liver-hepatalgia, &c.), affections of the vagus-hooping cough. II.-Action on the blood itself in connection with abnormal circulation and plethora: changes in sanguification. (1.) Inflammations and inflammatory states occasioned by exciting elements, actions of the fresh air, violent movement, exertion, with predominant affection of the venous system (and of the nerves), acute and chronic. (a) Of the parenchyma, of the brain and the meninges, of the liver, of the uterus, &c. (b) Of the serous membranes, pleurisy, pericarditis, peritonitis. (c) d) e) Of the skin, of the cellular tissue, of the glands. (f) Of the mucous membrane, as catarrh (catarrhal inflammation,) of the nose, of the mouth, of the larynx, of the bronchial and pulmonary mucous membrane (influenza), of the bladder, uterus, stomach and intestines; gastric states and fever, pituitous fever. (g) The tendons, and fibrous membranes, as inflammatory, erethistic rheumatism (or rheumatic inflammation), occasioned by the irritating action of the suppressed cutaneous transpiration on the blood. Compare also gout. (2.) Effusions, from similar causes as inflammations, consequences of local or general hyperzemia. (a) Exudations as terminations of inflammation, serous, especially in the serous membranes --hydrops acutus; sero-albuminous in the mucous membranes -as catarrhal exudation. (b) Lymphatic deposits in the glands, scrophulous affections. (c) Typhus infiltrations. See fever. (d) Exanthematic formations. (3.) Fever with changes in the blood tending to decomposition; typhus in the first stages; intermittent PHARMACODYNAMICS. 121 fever in connection with hepatic, splenic, and spinal affections of a plethoric kind. (The symptomatic fever compare with the local states.) (4.) General venosity: venous plethora or abdominal, hoemorrhoidal, and menstrual plethora in consequence of exciting conditions (diet), sedentary mode of life; the albuminous venosity of Engel, which gives the well known venous constitution of the blood. It occasions secondarily: congestions, hemorrhages, neuroses, inflammations, exanthemata, frequently also catarrhs, especially the gastric variety. It also occasions(a) Bilious states, diseases of the liver and biliary apparatus. (b) Gout: affections of this character of the fibrous membrane, joints, &c., with erethistic, inflammatory character. (Bryony will suit only those forms of gout which agree with its general type.) E. For the purpose of a general view, the forms of disease may be arranged in topographical order. 1. HEAD. Brain and Congestion, inflamits membranes. mation. Typhus. Hydrocephalus acutus. Sensational affections. Neuralgia. Hemicrania. Skull. Rheumatism. Face. Inflammatory prosopalgia. Neuroses. Rheumatism. The Eyes. Congestion. Inflammation. Catarrh. 1 Neuroses. The Ear. Congestion. Inflammation. Catarrh. Swelling. Neuroses. The Nose. Epistaxis. Ozoena. Coryza. The Lips. Hydroa. Aphthae. The Mouth. Gastric, bilious, inS flammatory symptoms. The Teeth. Congestive, Inflamm., Tooth Carious, ache. Rheumatic, 122 RULES FOR THE STUDY OF 2. TIE THROAT. The Palate. Angina faucium et tonsillaris. Inflammation, or Catarrh. Larynx. Laryngitis. Trachece. Tracheitis. (Influenza). Chronic catarrh. Hooping cough. Spasmodic cough. 3. THE CHEST. External Chest. Pleurce. Rheumatism, apyretic stitches. Pleuritis muscularis et serosa. Bronchice. Bronchitis. Lungs. Pneumonia. Hydrothorax. Haemoptoe and hmemoptoic infiltration. Tuberculosis and inflammation. Dropsical asthma. Acute states of tuberculosis. Heart. Venous obstructions in the circulation. Pericardium. Pericarditis. Mammce. Mastitis and hypermmic states during suckling and weaning. Diaphragm. Inflammation. 4. ABDOMEN. Stomach. Congestion. Inflammation. Catarrh. (Gastric states). Cardialgia (Congestivo-venosa). Intestines and Congestion. Peritonceum. Inflammation. Peritonitis, Puerperalis, Muscularis, Serosa, Enterodynia. Hydrops. acutus. Ileus? (Typh.) Diarrhcea. Constipation. Liver and Congestion. Spleen. Inflammation. Bilious states. Bladder. Congestion. Inflammation, or Catarrh. (Dysuria). Kidnies. Congestion. Bright's Disease. 5. PELVIS. Ovarium. Hypersemia. (Phlebitis?). Uterus. Acute menstrual anomalies and consequences. 6. BACK, OUTER THROAT, AND NAPE OF THE NECK. Inflammatory neuralgia. Rheumatism. Hyperemia (Menstrual and I-Imorrhoidal affections). Spinal irritation. 7. EXTREMITIES. Rheumatism (Lumbago, ischias). Arthritis, acuta et chronica. Inflammation of muscles. Inflammation of joints. Inflammation of skin and cellular membrane. PI-IARMACODYNAMICS. 123 8. SKIN. Miliaria. Purpura hmmorrhagica. Erysipelas (Pseudo-erysipelas). Urticaria. Icterus. (Morbilli, Scarlatina, Variole). 9. GENERAL AFFECTIONS. Fever: Typhus, Intermittent fever (inflammatory, catarrhal, gastric, venous-bilious, exanthematic, rheumatic, gouty fever). N. B.-The special indications for contained in the foregoing symptoms, always refei in the choice. these diseases are to which we must Hi. EXAMPLE OF THE SYNTHETICO-ANALYTIC MODE OF TREATMENT. THt, ACTIONS OF THE RHUS TOXJCODENDRON, (POISON-OAK, OR SUMACH,) ACCORDING TO IIAIINEMANN'S MATERIA MEDICA PURA, Bk. IT, p. 361-417. 18 R1ULES FOR THE STUDY OF Feeling of weakness at the heart; trembling of the heart; suppression of the lacteal secretion. Constriction; oppression of the chest and short breathing, with weakness of the limbs-as if without feeling in the chest, numb and stiff; short breathing, even to suffocation; a constriction of the trachea; tickling cough, with shortness of breath; cough like whooping cough. Feeling in left shoulder as if paralysed; pain in the nape of the neck like lead; pain as of bruise over the loins, weight, pressure. Trembling in the arms, (cannot keep the arms up,) in the limbs after being used; powerlessness and stiffiless of the forearm and finger on movement; coldness of the forearm, as if bruised; feeling on the skin of the forearm as if rubbed with wool or scraped with a knife, with feeling of coldness; finger as if asleep, numb, with tingling; crampish drawing inwards. Thigh as if bruised, with paralysis in the anterior muscles; jerks, with trembling of the knee; after walking buzzing sensation in the knees and ham. Stiffness. Cold in the left shin bone. Tottering. Paralytic drawing in the foot. Extreme weight in the hams and calves. Uncommon weakness in the legs; they feel heavy and bruised, as if paralysed. Spasmodic drawing of the calves and cramp. Vibration in the legs, with restlessness. Tingling in the feet, in the paralysed parts. Loss of feeling and numbness of the under part of the feet, as if they were of wood. Spasmodic contraction of the soles and toes. Paralysis of the lower extremities; shuffling and slow walk. The limbs, on which one lies, go to sleep. Trembling in the arms and legs, even at rest. Jerking of the limbs, of particular muscles. Great weakness in the whole body, as if the bones felt sore; weakness, sensation as if bruised. Semilateral contractions of the arms and legs, especially at night. Disposition to lie down; cannot keep out of bed, must lie down an hour at a time in order to gather strength; on lying down drawing in all the limbs. Feeling of fatigue, worse when sitting, less on movement. Paralysis over the whole body, in all the joints. Tottering, cannot stand upright. Fainting, with retention of consciousness, without pulsation of heart, rather cold than warm. Somnolence; sleepiness, even in the day, with anxiety, restlessness, melancholy. Restlessness when sleeping in the day. Movements and playing of the fingers and hands in sleep. Much violent and spasmodic yawning, with danger of dislocating the jawbone. Restless, interrupted sleep, with tossing and anxiety. After waking out of sleep in convulsions, shrieks on account of excessive headache, and feeling of dislocation in the limbs. Sleeplessness, with and without sweat and heat. Anxious, frightful dreams; muttering delirium. Somnolence, with troublous dreams; could go to sleep while walking; unpleasant thoughts, and dozing into sleep. Sleep not 132 RULES FOR THE STUDY OF gastric region, back); as of ulceration (behind on the palate); dull and pointed (epiglottis); itching (nape of the neck); fine (head, sternum, limbs); drawing (over limbs; throbbing (region of the heart); boring (ribs, upper arm, thigh); tearing (chest to the abdomen, wrist, tibia); drawing twitching (coccyx); burning (axilla, back of the foot, toes); spasmodic (ankle); jerking (ball of the toes); shooting outwards (lower limbs). Pain as from bruise (brain, orbital cavity in the bones, maxillary joint, temples, throat, sacrum, sides of the lumbar vertebra, limbs; -in the ulcers; general). Cutting (eyes, cheeks, feeth, umbilicus, abdomen); tensive (scapula). And the sub-species: Routing or digging (abdomen, bones of the hand); and twisting (abdomen). Itching (hairy scalp, face, rectum, mamm0e, nipples, throat, fore arm, limbs, ham-strings, hairy parts); gnawing (scalp, hands); smarting (eyelids and angles of eyes); shooting (prepuce, calves, toes); burning (elbows, hands, chilblains). And the sub-species: Tingling (forehead, occiput, ear, gums, stomach, rectum, finger, knee, leg, feet; face, spine, and sternum; in the ulcers); itching (ear); as needle scratches or pricks (teeth). Tickling (air-passages). Pinching (finger). Burning (head, face, stomach, abdomen, rectum, urethra, chest, sacrum, arms and hands, between the fingers in the flesh, limbs, over the hips;-skin over the whole body); gnawing (fore arm); itching finger. And the sub-species: Smarting (eyes, urethra, parts of generation); as from salt (in the ulcers); burning (in the ulcers). Pain as of excoriation (nostrils, teeth, throat, anus, vagina, throat and trachea, on the chest, sacrum, corns). Burning' (gums). Pain as of ulceration (abdomen.) Throbbing (head, ear, epigastriumn, gastric region, balls of the toes). And the sub-species: (Legs, back of the feet); pulsation. Beating (teeth, throat, elbows, foot); cutting (back of the palate). Swashing as of water (hands, calves). PHARMACODYNAMICS. 135 consequently in Rhus aggravations on lying down, while sitting, which compel one to get up, piedominate over the qpposite observations. The occasional relief from touch is not quite to be overlooked, since in vascular affections pressure aggravates, in nervous relieves. The action of the open air points to rheumatic nervous affections (see the pathology). B. The diseases answering to the proper actions of Rhus, which is itself an wetiological element in the production of diseases in this direction, are occasioned by debilitating actions of every kind, acting partly primarily on the nerves, as emotions, immoderate exertions; partly secondarily on the vascular activity, as bad nourishment, loss of fluids, previous diseases, miasmatic contagions, or sporadic decomposition of the blood, wettings. It is of little moment whether excitement precedes these depressing elements, though this is frequently the case, for we have to do here merely with the result, the asthenia, whether it be direct or indirect (according to Brown). C. If at our first study we obtain a general view of the seat or locality of the affections, and see that besides the mind and general feelings certain organs and parts are specially affected, as the head (forehead, occiput), the face, the organs of the senses, the teeth, the outer throat and parts about the nape of the neck, the stomach, the abdomen, the pelvic organs, the nose, the windpipe, the larynx, the lungs, the back, the extremities, the skin, we shall on a more attentive perusal, and particularly on a comparison of the physiological phenomena arrive at a definite anatomical constitution. (1.) The nerves appear to be predominantly affected, as is already clear from the foregoing peculiarities, and particularly the brain (cerebellum), the spinal marrow with its ramifications, though likewise the 136 RIULES FOR THE STUDY OF ganglionic (stomach, intestinal, genital, and cardiac parts), and the vaso-motory nerves. In every case the fundamental action of Rhus depends on this specific relation to the nervous system, and in most cases this is its primary action (compare neuroses and affections of the blood). Though the motory apparatus of the same is transmitted,(2.) The relation to the vascular system, specially to the venous and the capillary system, the lymphatic and the glandular system (the lacrymal glands, the submaxillary, the parotid, the sublingual, the cervical, the inguinal and the axillary glands, the mamme); compare states of decomposition, (hcemorrhages, exudations, colliquations, inflammations, fevers, dyscrasias). The working of this anatomical constitution shows itself further in the relations to the(3.) M[uscles, the fibrous membranes, and the articular apparatus (face, throat, nape of the neck, chest, heart, shoulder, back, especially the loins, axilla, glutsei, hips, extremities; gums, maxillary, axillary, elbow, hand, finger, hip, knee, and ankle-joints). Compare rheumatic and arthritic affections, and those from over exertion, lifting, sprain,(4.) To the mucous membranes (eyelids, eyes, ears, Eustachian tube, nose, lips, mouth, inner throat, palate, tongue, stomach, intestines, bladder, urethra, uterus, trachea, larynx, bronchie). Compare catarrh, hemorrhage, exudations, ulcers,(5.) To the serous membranes (peritonoeum, pleure, endocardium, meninges). Compare inflammations, exudations(6.) To the skin and cellular membrane (head, face, ear, throat, scrotum, and genitals, chest, back, extremities). Compare states of decomposition, exudations, exanthemata, inflammation, dyscrasias, (ulcers, &c.). (7.) To the bones and the periosteum (cheek, orbits, zygomatic bone, frontal bone, maxillary teeth, clavicle, sternum, ribs, spines and bodies of the vertebre, PHARMACODYNAMICS. 137 axille, extremities-(joints, see above). Compare rheumatalgia, dyscrasice (gouty, scrophulous, rhachitic). D. Keeping closely in view the fundamental character of weakness (asthenia) with the double manifestation of paralysis (torpor), or of versatility (excitement), we can now, with the aid of watiology and anatomical (local-specific) conditions, proceed to the investigation of the pathological relations. Certain principal forms of morbid states will come out as we proceed, and show that one band connects all these varieties, the fundamental action of an abnormal inervation, which permeates all stages from asthenic' versatility, through depression to real exhaustion and paralysis of the vital activity. We find then, to anticipate in groups the results of what has been topographically investigated (see E). I.-IN THE SPHERE OF THE NERVOUS SYSTEM. Neuroses of all kinds, occasioned by weakening influences of all kinds (as loss of fluids, degeneration of the blood, bad nutrition) upon the brain, spinal marrow, ganglions and their ramifications. (a) Neuroses with the character of torpid asthenia and real exhaustion, paralytic states, and particularly palsy (of the eyelids, amaurosis, deafness, of the spinal marrow, of the bladder, &c.), paraplegia and hemiplegia, epileptic states, agrypnia, sopor, states of debility during convalescence from severe illnesses, melancholy, hypochondria, weakness of intellect, imbecility. (b) Neuroses with the character of versatile asthenia, weakness with over excitement, spasmodic states, "and particularly convulsions, chorea, tetanus, spasmodic yawning, nervous giddiness, nervous headaches, megrim, prosopalgia nervosa, odontalgia, neuralgia of the stomach (cardialgia) and of the bowels (entero-dynia), neuroses of the bladder 138 RULES FOR THE STUDY OF (retention of urine), spasmodic laryngeal and tracheal affections (cough), nervous asthma from affection of the vagus and of the heart, neuroses of the spinal marrow, spinal irritation, pains in the back, loins, and limbs, ischias, neuralgia of the skin. To this section also belong, with the special affection of the fibrous parts, muscles, bones, joints, in consequence of being wet through, and from the debilitating action of cold, the rheumatic affections of Rhus which do not, as in Bryony, depend on vascular affections (hyperoemia), but on nervous affections, and which express themselves in conformity with the Rhus character, either as palsies or as neuralgias (rheumatalgia): like the affections arising from over exertion (strain, sprain, contusion), which belong likewise to the neuralgim. II.-In the sphere of the vascular system, hmmatonoses, occasioned by weakening influences in the form of decomposition or of degeneration. If we suppose the nervous affection as the primary element of action, it follows, that the morbid affections of the blood-life, which Rhus points out, will be only of a secondary kind, and will arrange themselves in the sphere of metamorphoses as a real torpor or paralysis of the vascular walls, more rarely as states of excitement with the character of weakness. This will accord with the already explained action on the nerves. We have consequently, as the defective nutrition, and the morbid assimilation of the fluids may act injuriously on the nerves and induce effects answering to Rhus, to expect also proceeding from the nerves similar states for the blood-life. For both kinds of states, which often complicate each other mutually, also in the so-called nervous diseases, Rhus is adapted. The following special forms are here to be mentioned. (a) Diseases of the blood with the character of decomposition and of degeneration through weakening influences, such as defective nutrition, loss of fluids, miasmatic and contagious action. PHARMACODYNAM ICS. 139 (aa) PARALYTIC STATES. (1.) Putrid decomposition on the skin and cellular tissue; morbus maculosus Werlhofii; purpura hbemorrhagica; petechiae; carbuncles; pustula maligna; ulcera pedum phagedenica, gangrenosa. (2.) Exudations on the skin and the cellular tissue; blood swellings (encephaloematoma neonatorum); perniones; hydrops, particularly after cutaneous eruptions, cedema scroti; in the serous membranes; dropsical exudations (hydrocephalas acutus--(Mor. Mueller); hydrops pericardii; endocardii; hydrothorax: hydrops peritonei; articular dropsy; In the parenchyma; cedema pulmonum? (3.) Colliquations, in phthisis and consumptions, acting symptomatically. (4.) Hemorrhages, especially in the mucous membranes (epistaxis, pneumonorrhagia, dysenteric h-emorrhage, uterine hEemorrhage). (bb) VERSATILE ASTHENIC STATES. (1.) Inflammation with nervous or dyscrasic character, and disposition to decomposition, in consequence of chill and abnormal nutrition. (See 2). In the mucous membranes, as asthenic-catarrhal, scrophulous inflammation of the eyes, eyelids, psoropthalmia; blennorrhcea of the lids; otitis; otorrhoea; inflammation of the nose; ozoena; catarrh or inflammation of the Eustachian tube, of the nose, of the trachea, of the larynx, of the bronchise, of the lungs (hepatization with nervous state); grippe, catarrh or inflammation of the palatal parts; oesophagus; ventriculo-intestinal catarrh; diarrhoea; dysentery (especially the reflex nervous phenomena of the same); catarrhus vesicme; uterus; In the serous membranes with disposition to decom 140 RULES FOR THE STUDY OF position (effusion); pleurisy, endocarditis; peritonitis, meningitis, in consequence of debilitating influences or chills, less against the inflammation itself, than against the nervous accompaniments and consequences (decomposition); In the fibrous membranes, muscles, bones, as rheumatic and dyscrasic inflammation; In the glands in the same way (parotitis, &c.). (See above C.) (2.) Exudations, especially in the skin, exanthematic eruptions, scarlatina miliaris, morbilli, erysipelas bullosum, pustulosum, neonatorum; variola, variolois, urticaria, pemphigus, where nervous excitement concurs with decompositions. (3.) Febrile states, and particularly as well the symptomatic, when they incline to morbid states of the assimilation,-for example, take on pyoemic action (puerperal and the so-called status nervosus, putridus, as also idiopathic, in especial, intermittent fever, typhus under all forms). (b) Diseases of the blood with the character of depraved nutrition, with torpor and depression of the vascular life; dyscrasime; In the lymphatic and glandular systems; scrophulosis; induration; swelling of the glands; In the cutaneous system; dyscrasic exanthemataas psoriasis, impetigines, herpes, especially of the face, tinea capitis, lepra, gutta rosacea, rhagades, verrucm, chiefly in scrophulous diathesis; In the bones and cartilages-rhachitis, tophus, caries; I PHARMACODYNAMICS. 141 In the joints, muscles, fibrous parts; arthritis acuta et chronica, chiefly with neuralgic character or with effusion; articular diseases with scrophulous diathesis. E. We shall be justified in this arrangement, if descending from generals to particulars we here survey the individual forms in topographical arrangement in the order of the Hahnemannian schema, according to their concrete appearances as the groundwork of the whole. HEAD. (Neuroses.) Giddiness, pure nervous giddiness. (Incipient softening of the brain?) (Spt. 1-9, 11, 12, 14, 16-19, 51). Compare headache. As if drunk; violent giddiness; every thing turns round with him; wavering, tottering, and reeling in the body; as if he was held up aloft; with heaviness; on stooping as if the blood shot into the brain, as if he could not rise again. Cephalalgia.-Rheumatic, gouty, and nervous headache. (Spt. 13, 18, 20-25, 33, 37-50, 51, 88). Confusion without any definite pain; headache, as if stupified, and humming in the head; inebriation; tightness of head, with difficulty of thinking; reeling headache, over the whole head; head full and heavy, as if the brain fell forwards; as if the brain were loose and struck against the skull; across the forehead, in" the occiput; pressive headache, as if with a dull point; pressive drawing on the left side of the hairy scalp towards the upper part; and deep over and behind the right orbit a pressive downwards, as of a weight; headache, as if the eyes were pressed out of the head, with yawning and chilliness, without thirst. Constant weight in the head on stooping, as if a weight fell forwards; also in the temples; as if the brain were compressed on both sides; as if the forehead were pressed asunder, with weight, on coming out of the open air into the room, or on waking out of the mid-day's sleep. Burning pressure on the right temporal bone. Tearing pain all over, stronger on the left side, with external pain, as of excoriation, in the right temple across on the hairy scalp. Drawing in the occiput and the temples, with pressive pain in the eyes. Headache, as from disordered stomach. Violent headache, 142 RULES FOR THE STUDY OF as if the brain were torn to pieces, as after a debauch; in the occiput as if it were a bruised pain; in the temples a pressure outwards. Fluctuation, as of water in the brain. Creeping and formication over the forehead and the nose, disappearing on stooping. Shoots outwards. Fine throbbing in the right side. Burning in the head and fine throbbing or clawing headache in the occiput, sometimes in the forehead. Fine violent shoots in the right temple inwards. Sudden jerks in the occiput. Shoot during eating, then sickness and fulness. Burning creeping in the forehead. As if a painful digging with a needle, a fine stitch-like digging. Headache as if external, the skin as if constricted and plucked up, yet not painful under the touch. States of depression in cerebral activity. Weakness of mind. Weakness of memory. Imbecility. (Spt. 10, 16, 22, 25-32, 35, 36). Compare psychial states under A. A stupified state, a weakness in the head. Oppression and want of desire for literary work. Prostration, thought is difficult, speaking troublesome, and against the grain. Cannot put thoughts together; quite stupid. Slow movement of the ideas. Forgetfulness. Dull weak memory. Loss of thoughts; as if in thought, and yet want of ideas. Diseases of the outer head. (Compare face, skin). Encephalatoma. Exanthema. (Spt. 87-92). Creeping on one spot of the occiput, as if an ulcer would form there; upon the scalp; hairy scalp painful on being felt, and on brushing the hair back; external pain, as of boil. Gnawing itching, where a miliary pimple comes out. (The other symptoms mentioned here by IHahnemann relate to stomach affections and febrile states.) FACE. (Neuroses.) Prosopalgia nervosa and rheumatica. (Symptoms, 97, 114, 153-156, 184, 186, 188-190, 193, 194, 196, 200, 203.) The face is deformed and distorted; the left side as if drawn together and shorter; the right as if elongated. Drawing and tearing in the region of the eyebrows and in the cheek bones. On the inner side of the socket towards the nose, in the bone, pain as of bruise. Pressure with fine shoots in the zygomatic bone; upon the frontal bone. Dull drawing on the left side of the forehead, through the left cheek down the jaw, through the muscles and teeth, as if toothache was commencing. In the evening shooting twitching, in single jerks, out from the temples into both jaws and rows of teeth, with weakness, pain as of PHARMACODYNAMICS. 143 bruise in the left temple, yawning. In the under lip a pinching spot. Vibration and cracking in the maxillary joint. A pain in the maxillary joiht, deep under the ear, as of cramp, during rest and on movement, relieved by strong pressure from without and the use of warm things; as if bruised, as if it would break. Like needle prickings in the cheek. Cutting, then itching and shooting. Cutting constriction in the cheeks. (Affections of the Blood.) Exudations a); exanthemata, dyscrasic:-crusta lactea, impetigo, Psoriasis, herpes, Tinea faciei, gutta rosacea, acne, lepra, pustula maligna, carbunculus, acute cutaneous eruptions, as maculme or miliaria (scarlatina), wheals and points (urticariae, morbilli), vesicular and pustular formations (Zone, Erysipelas bullosum and pustulosum, variola and its cognates, pemphigus). Compare febrile states and skin (spymtoms, 97, 114, 180, 181, 183, 185, 186, 187, 192). Redness and sweat, without thirst. Scaling of the skin. Great swelling, the head as big again, phlegmonous vesicular erysipelas. Erysipelatous swelling of the face and neck; of the eyelids; of the lobules of the ear, with violent burning, tension; cannot open the eyes for eight days. Fine scales on the face. Vesicular erysipelas, with burning pain, tears in the eyes, vesicles full of yellow water, burst, then a mealy desquamation. Cramp in the right cheek, as if it would ulcerate, with heat and roughness of the cheek, as if a rash was about to appear. Upon a wrinkle of the cheek a pustule, painless till it is handled, when it pricks. 'Burning vesicle about the mouth and on the nostril. A pimple on the lower lip, below the red part. Dry, parched lips, with reddish crust. Clusters of pimples, which are filled with a watery fluid when first forming, they are near the corners of the mouth, on the border of the lower lip, feel sore when touched, and when not touched a smarting sensation, as if occasioned by salt, is experienced in them. Pimples on the side of the chin, with pus at their tips, on being touched a feeling as if a sharp wedge was pressed into them, accompanied with a continuous burning. b. H-ydrops (after rashes?). (S. 108). Swelling of the head, throat, and the chest, down to the navel. THE EYES. (Neuroses.) Palsy of the lids, amblyopia amaurotica, amaurosis, (S. 127, 128, 151). Twitches and constriction; weight and stiffness in the eyelids, like palsy, difficult to move. Weakness of sight; objects are pale. Sensation as of gauze before the eyes. 144 RULES FOR THE STUDY OF (Affections of the Blood.) Inflammatory states and catarrhal, dyscrasic (scrophulous, rheumatic, gouty), blepharitis and ophthalmia. Blennorrhoea palpebrarum (of new-born infants), photophobia scrophulosa, corneitis? (S. 115-152.) Inflammation of the lids. Smarting itching on the upper eyelid, disappearing on rubbing. On the inner surface of the right upper eyelid a feeling as if swollen, with pressure, going off in the open air. The eyelids are dry, as if drawn together by sleep; much swollen. Twitching of the lids, with feeling of dryness, during a febrile chilliness. Lids in the cold air as if sore, from saltish, smarting tears. Itching in the right external angle of the eye. Red, hard swelling, like a stye, on the lower left lid, towards the inner angle, with pressing pain, for six days. Feeling of swelling in the right inner angle. Smarting as if from acrid acid in the right eye. Pain in the eye-ball on turning and pressing it. Pressure, as from dust. Periodic cutting in the eye, with difficulty of opening the lids in the morning. Pressure on straining the sight, as if from inflammation in the left eye, with redness of the inner angle, and closure, as from mucus, in the evening. Pressure and constriction; burning pressing feeling in the eye. In the morning the white is red, the eyes project; are red and agglutinated with matter. Ophthalmia. Weeping eyes, with cedematous swelling around them. In the evening lacrymation with burning pain. EARS. (Neuroses.) Nervous dysecoia, buzzing, ear-ache, (rheumatic). (Spt. 157-159, 161, 164, 165, 182). Ringing in the right ear on walking. Two violent cracks in the left ear, as if the membranas tympani has burst; while lying down and in the act of going to sleep, he started up. Buzzing before the ear. Squeaking in the ear, as of young mice. Coldness in the closed mouth, with roaring in the left ear. Ear-ache. Fine, painful tearing behind the left ear. (Affections of the Blood.) (Inflammation dyscrasic;) otitis scrophulosa. Otorrhmea (S. 160, 162, 163, 166). Painful throbbing, at night, in the internal ear. Sudden drawing pain, as if a thread was being drawn through. Before the right ear, as if something was blowing within, or lay before it. Itching creeping in the ears, as if there was something alive in them, compelling him to put his finger in. PHARMACODYNAMICS. 145 NOSE. (Affections of the Blood.) Epistaxis (Spt. 168-170, 176, 177). Epistaxis, hardly ever except on stooping; on hawking. (Dyscrasia); scrophulous inflammation of the nose, ozoena, exanthemata (S. 171-175, 178, 179, 181). Feeling of hardness and swelling under the nose, going away on being felt. Tension under the right nostril. Hot burning under the left nostril, so that the breath seems to come hot through it. Apex of the nose hot, painful to touch, as if it would suppurate. Sensation of excoriation in the nostrils. Scabby eruption near the left ala nasi and under the nose. An herpetic eruption about the nose and mouth, sometimes with twitching and burning therein. Burning vesicles about the nose and mouth. Spt. 167.-Swelling of the nose, of the ears, and of the neck, appears to be of rheumatic character. PAROTID AND SUBMAXILLARY GLANDS. (Dyscrasic Inflammation.) Parotitis and inflammation of the sub-maxillary gland (acute and chronic), scrophulous, rheumatic (S. 198, 201, 202). The glands under the angle of the jaw pain, even without being moved, as if from being pressed and dug into. Swollen, hard parotid and submaxillary glands; swelling of the submaxillary gland, with shooting on swallowing. TEETH. (Neuroses and Dyscrasia.) Odontalgia nervosa (rheumatica), arthritica, cariosa (S. 191, 199, 204-225). Burning constriction in the right cheek, with pressing pain in the crown of the three upper molares. Feeling as if the gums were squeezed together on both sides. Slow shooting, and at the same time jerks in the cuspidati. Jerls at night into the head, eased by applying the hand; in the roots of the nerves of the hollow teeth; in the nerves from below upwards. Pressure in the external side of the gum of the lower back teeth, at the same time in the axilla; dull, at the same time, in the shoulder. Sharp and dull pain, with musty smell, in the mouth. Pain in the upper teeth, as if they would be drawn in by the roots into *'. - L;.;: 146 RULES FOR THE STUDY OF their sockets; feeling as if a tenacious body were between them. Feeling compounded of cutting and soreness. Intolerable burning pain, as of excoriation, in the gum to the root of the back teeth, compelling the patient to sit up, with feeling of heat in the body, and particularly about the head, with sweat on the forehead. Cutting beating pain in that portion of the palate where the teeth terminate, as if from ulceration; contact occasions a pricking, as from an ulcer. Pressure in the inner gums of the fore teeth, and in the periosteum of the sockets, shifting to and fro. Looseness, painful creeping, like a digging with a needle. Pain merely on biting and chewing, as if too long and loose, yet do they not shake, and they do not pain on being felt. Toothache, first in the hollow teeth, which are longer and looser, then in the upper ones shooting and creeping. Cold and warm drinks touching with the tongue give pain. Visible shaking, even when not chewing. The gums separate from the shaking teeth; they can be separated from these teeth and touched without pain, except when the teeth themselves are painful. MOUTH, TONGUE, SALIVARY GLANDS, &c. Symptoms of nervous (febrile) and catarrhal affections (S. 226-234, 236). Accumulation of water in the mouth, of a saltish taste. Dribbling from the mouth during sleep; he must often spit out much saliva and tough mucus. Something comes up from the stomach therewith which tastes sour, hawking up of mucus in the morning, on rinsing the mouth out it is worse; in the morning saltish mucus on the tongue. Tongue not coated, dry, exciting one to drink. Feeling of dryness on the point of the tongue, unallayed by drinking, much mucus in the mouth without taste. THROAT, PHARYNX, &c. Symptoms of paralysis of the pharynx, of nervous (febrile) and catarrhal states of the pharyngeal mucous membrane and angina tonsillaris (S. 235, 236, 246-254). Feeling of dryness in the throat; thirst; tough mucus in the throat, disappearing after a little hawking, leaving behind some roughness. Feeling of swelling with pain as of bruise, with or without talking; on swallowing, hiccoughing, yawning, especially on empty swallowing there is pressing pain; pressive pain as of swelling with shooting, as if something pointed (a needle) had stuck in. Cannot drink, chokes at each drink; there is, as it were, inactivity or torpor of the epiglottis (?) with feeling of dryness in the throat. Throbbing at the back part of PI-ARMACODYNAMICS. 147 pharynx, violent shoots, beginning dull, ending pointed and sharp, in the region of the epiglottis, when not swallowing, dispelled on swallowing. On swallowing shoots, when the throat is dry, pressure when it is moist. Feeling in the left tonsil as of roughness, and excoriation on swallowing. STOMACH, GASTRIC AFFECTIONS, APPETITE, &c. (Neuroses.) Affections of the ganglia; cardialgia. (Diseases of the Blood.) (a) Asthenic affections of the mucous membrane in the form of gastric catarrh (status gastrico-pituitosus), idiopathic and symptomatic. (b) States of decomposition; symptomatic appearances in typhus, putrid and similar states (the perforating ulcer of the stomach?). (S. 255-349, 355.) Putrid taste after eating and waking, without bad smell of the mouth; greasy in the mouth, but food tastes properly; as if after putrid meat; putrid, slimy, insipid; bread tastes rough, dry, scurfy, bitterish; beer does not taste; bitter taste in the morning, going away after eating; bread and acids taste bitter. After the use of milk acid at the stomach. Appetite.-Repugnance to bread, meat, broth, eating in general, several times a day; desire for cold milk. Full after wine, repugnance therefore with weight in the head; disinclination to coffee, tobacco; but no loathing at them. Sudden appetite for dainties. Entire loss of appetite; becomes immediately satisfied and yet there is hunger; with emptiness in the stomach and violent hunger. Weight in the abdomen which seems quite empty, with hunger; in the morning hunger going away at table, yet eating does not gratify; as if hunger attacked the "chest; fulness under the sternum, as if the appetite had gone for ever. Stomach constantly as if full; tolerable relish for food but no appetite. Loathing with shuddering and nausea, with shivering over the whole body without chilliness; squeamishness and vomiturition in the morning as if in the chest. Nausea as if in the throat; in the chest with craving hunger, disappearing on eating; in the stomach with squeamishness in the chest, increased on stooping or after eating and drinking. Eructations and fulness after moderate eating; craving hunger, soapy taste in the mouth, all tastes like straw, with eructation, appetite immediately goes away, with fulness after eating; creeping in the mouth, and terrible eructations, relieved by lying down, returning on rising up again. Empty eructation after eating and drinking; in the L2 148 RULES FOR THE STUDY OF evening violent eructations of air, then hiccough; eructation- from the stomach losing itself in the chest, as if it would remain there; after eating, as if burning; after eating, giddy, uneasy in the stomach with distension; immense and sudden weakness in the head, with giddiness and tendency to fall forwards, headache, toothache, cough, weariness, extraordinary somnolence; headache after drinking beer; feeling as of heat; shuddering after eating. Pressure in the stomach, as after something indigestible; pinching in the abdomen; pressing, drawing hitherwards in the left hypochondrium, with anxiety, and nausea in the chest; with anxiety going away in the open air. In the evening frequent rising from the epigastrium to the pit of the throat, nearly taking away the breath for the moment. Pressure on the epigastrium as if swollen up, taking away the breath; as if from a large morsel swallowed; oppression as of constriction, as if full and tight; shoots in the epigastrium, in the right hypochondrium; pinching in the epigastrium, and from thence into the abdomen at a small place; violent throbbing in the epigastrium; pain in the stomach, as of a lump after eating; under the diaphragm, above the stomach, a painful pinching, then deeper in the stomach itself; constriction from the right towards the stomach; pressive shooting in the region of the stomach, preventing a deep breath. Warm and squeamish as if to vomit, giving up on lying down again; straining as if to vomit, at night in sleep; accumulation of saliva with vomiturition to overflowing, and yet hunger. ABDOMEN, STOOL, ANUS. (Neuroses.) Ganglionic and spinal affections, enterodynia, colic, especially the spastic and rheumatic. (Diseases of the Blood.) Asthenic affections of the mucous membrane. (a) In the form of catarrh of the intestines, of diarrhoea (also from rheumatic causes), or of catarrhal dysentery. (b.) Or of ulcerative dysentery. (c.) Symptoms of typhoid and putrid affections (S. 350-3544, 356-435). Sense of obstruction or of pressing upwards in the hypochondria with anxiety, as if death were impending, while sitting bent forwards; pressing upwards in the abdomen as if the intestines were raised towards the heart; sense of distension and of heat on the breast while rising after stooping; a pressing in the left side under the ribs; shoots PHARMACODYNAMICS. 149 from the right towards the stomach. Pain in the abdomen as of a heavy lump; on sitting, pain as if pressed. Pressing on a small place as if wind had become incarcerated, merely on turning, not on being felt. Pinching in the region of the umbilicus, with chilliness running over the upper arm; during sitting with oppression ascending from below upwards; under the ribs, on the right, towards the navel as from worms,; with incarcerated flatulence, of which no little passes off, while walking in the open air; almost a twitching pinching in different parts of the abdomen; extraordinary during a natural stool; violent with distension in the region of the navel. Digging pain in the right side of the abdomen; shooting from the navel towards the region of the heart, repeated at each pulsation; over the navel, Drawing from the umbilicus to the mons veneris. Pain as of bruise under the navel; visible constriction in the middle of the abdomen, across the umbilicus, so that the abdomen under and above this constricted band feels distended, hard and rigid. Spasmodic drawing in the region of the navel; cutting in the left side of the navel on expiration, when sitting; spasmodic pains in the right side of the abdomen, early in the morning, when taking a little cold, accompanied with a moaning, desponding, disconsolate mood; first cutting, then shooting towards the right. Colic composed of cutting, tearing, 'pinching, without much flatulence and distension, affecting the whole intestines, worse on moving, better when at rest. Painful distension with colic. Painful distension with colic, as from incarcerated flatulence, soon after a meal. Scarlet redness, four fingers broad, under the navel. Distension of the abdomen with fermentation, very stinking flatus. Burning in the abdomen with thirst; digging up and writhing colic, as if a worm was moving itself; drawing to the left on fetching a breath; crackling and rumbling, with shocks to the mons veneris. Fulness and fermentation with hunger, going away after a meal; jerks from flatulence; pressure; jerks and pinching; while walking the interior of the abdomen feels lax, and it shakes at every step. In the morning on stretching the abdomen feels sore, and the integuments too short. In the right side of the abdomen drawing pressure, and in the skin of the abdomen feeling as if covered with a spider's web; pressing on the mons veneris, with sensation as if stretched. Drawing across the inguinal ring when sitting; tension with shooting; tension from within outwards in the left groin, as if from a hernia; weight as if a tumor were hanging down; pressing outwards with crackling and rumbling in the abdomen; constriction in the left groin, so that he must walk bent forwards. On the mons veneris two red, round spots, from blisters that have burst. In the middle of the abdomen, before noon, cutting, frequent stool, of natural appearance; lessened by bending forwards, increased on walking. Constant pressure to stool, with nausea and tearing in the bowels, PHARMACODYNAMICS. 151 turbid, when he makes it; soon becoming turbid; whitish and muddy; always whitish and muddy the longer he urinates, the last drops turbid as if flocks; like water with a snow-white deposit (double stream). Exudation a): dropsical, oedema scroti et praeputii: (b) exanthematic, erysipelas bullosum, miliaria, herpes (S. 451 -468). Frightful eruption on the parts of generation; swelling of the urethra; moist eruption on the scrotum, with swelling of the prepuce and glans; rigidity and swelling of the genitals; tympanitic, hard, thick, especially of the scrotum, with much itching; dark, scarlet redness, from the scrotum downwards, without swelling, becoming streaky in the middle of the thigh; miliary rash on the scrotum, moist; red spots on the inside of the prepuce, near the froenum. Pain of the glans on account of paraphimosis; dark prepuce; humid vesicle on the glans; a great vesicle under the prepuce on the glans, which burst the following day; swelling of the prepuce close to its union with the glans; shooting itching within the prepuce. (Consensual symptoms?) Pain of the inguinal glans, merely at night in bed, on turning and rising up, (449); in the left testicle a cutting drawing. Hmemorrhage from the uterus; premature menses; metrorrhagia. (S. 473-482).* Violent pains, as if the catamenia were about to commence immediately, deep in the abdomen; shoots in the vagina, not increased on touch; pain of excoriation soon after being felt. Haemorrhage from the uterus; without pain in a pregnant female. Return of the menses, which had been long suppressed, they flow strongly; violent smarting as they flow from the genitals. Curative action.-The catamenia cease suddenly to flow. MUCOUS MEMBRANE OF THE NOSE. Catarrh of the nose. Coryza with asthenic character (S. 483, 484, 488, 490, 492). Sneezing; violent, frequent, very frequent, nearly spasmodic; the mucous flows in quantity involuntarily from the nose, as in the most severe cold, in the morning, and yet he has no cold. (Nose obstructed, worse in the room). Coryza and cough, with expectoration. * The recommendation against menostasia, to which the element of chill could alone give any countenance, is uncertain; that against metritis is not borne out; that against putrescentra uteri, on general grounds, is hypothetical. 152 RULES FOR THE STUDY OF LARYNX AND TRACHEA. (S. 485-488, 491, 492, 517, 521, 522.) (Neuroses.) Spasmodic cough. (Affection of the Blood.) Catarrh with asthenic character, oedema glottidis. Influenza, chronic catarrh with bronchiectasis. Chronic hoarseness. Compare symptoms of the lungs. Hoarseness, deep in the windpipe; scraping, rough feeling, in the larynx, causing hoarseness. A roughness in the throat and in the windpipe, as if the chest were sore and raw, causing cough. Tickling irritation in the windpipe, as if to cough, shortening the breath, going away on moderate movement. Tickling cough, occasioning dryness of the throat, in the evening; in the pit of the throat. Sensation in the throat-pit as if the trachea were stopped up and constricted, passing off for a time after eating and drinking, but soon returning. Feeling of coldness in the throat on expiration, as if the breath was passing out cool. Ascension of a hot vapour (from the lungs). EXTERNAL CHEST. (S. 499-501, 844). (Affections of the Blood.) Exudations, consequences of suppressed secretion of milk. Itching in the breasts; itching in the left nipple; milk leaves the breasts; papular eruption on the right side of the breast, half way round the back, painful as if sore and excoriated, with four stitches from within outwards. PLEURAE AND LUNGS. (S. 494, 502-516, 518-520, 523-543, 548-552.) (Neuroses.) Rheumatalgia, pleuritica (but not against pleurisy). (Afections of the Blood.) (a) Inflammations with nervous, asthenic or putrid character; pneumonia nervosa in the stage of hepatisation, with impending cedema of the lungs, and the effects of infiltration, asthma, &c. PHARMACODYNAMICS. 153 (b) I-H morrhages; pneumorrhagia, cough with hemoptysis in asthenic, tuberculous subjects, and the consequences of hemoptoic deposits-asthma. (c) Emphysema. (d) Hydrothorax after eruptions. Endocarditis, rheumatica, &c. Deep shoots on both sides of the sternum; fine shoots, oppression on the sternum, causing dyspnoea, with constant short cough, without expectoration. Constriction on the sternum, with shooting jerks therein. Pain, as if something was pressing on the sternum. Oppression on the chest, as if after crying; of the cavity of the chest; pressing. Oppressed and anxious, as if one could not fetch a breath; with shoots especially on breathing. Constriction of the chest, with squeamishness and nausea; tension, quite short breath and weakness in all the limbs; unpleasant with cough; short breathing, especially on going to stool; cannot sit, must fetch a deep breath, as if to choke, especially after each meal. Dyspnoea, after walking; scraping and burning feeling on the chest, even independently of respiration. Slow drawing down the chest, not during respiration. Weakness, talking is troublesome. After walking in the open air sense of fulness, therewith hunger, without appetite; on the chest, as if without feeling, (numb anl stiff) hooping cough, with shaking in the chest, in the head, as if all were loose there. Dry cough, with shooting in one loin before midnightviolent, most so on waking, with black sticky expectoration; in the open air; very oppressive, with white mucus, day and night; short, anxious, painful, waking one up before midnight from sleep, with very short breathing. On coughing general sweat, pain in the stomach, vomiting of food; little sleep from his troubles. Taste of blood in the mouth, without h Semoptysis. Retching nausea under the short ribs, tightening the breath. Frequent hawking, with bitter taste in the mouth and throat, in the evening, and morning till getting up. Unpleasant feeling of heat in the chest on walking in the open air. Frequent stitches in the side on walking in the open air; violent and throbbing, with crying out, when sitting; tearing from the right breast to the left side of the abdomen; boring in one of the lowest ribs, on speaking and deep inspiration; violent in the left side under the ribs. Boring pain in the left, in the evening. Swelling and painfulness of the left side from the axilla below the ribs. HEART. (S. 547, 548. Many symptoms cited as belonging to the pleura and lungs, should have their place here). 154 RULES FOR THE STUDY OF (Neuroses.) Spasmodic heart affections reflected from the spinal marrow. (Affections of the Blood.) Symptoms of hydrops, pericardii, and endocardii, after rheumatic affection.* Unpleasant feeling of weakness in the heart; trembling of the heart; palpitation, when sitting, so violent that the body moves at each stroke of the pulse. BACK, NAPE, SHOULDER-BLADES, SACRUM, &c. S. 553-592). (Neuroses.) (a) Spinal irritation with asthenia. (b) Paralysis of the spinal marrow. (c) Rheumatalgia of the muscles of the back. (d) Neuralgic pains from over exerting the muscles of the back. (e) Ischias. (Affections of the Blood.) (a) Coxalgia. (b) Rachitic affections of the bones. (c) Gouty affections. Compare also the symptoms of the extremities and skin which follow. Nape of the neck feels sore on movement, as if stiff and tense. Itching shooting, like flea bites, in the nape of the neck. Pressure in the muscles of the neck on bending the head forward, in the upper part of the neck; the place feels numb. Drawing over the side of the neck on stooping. Rheumatic stiffness of the whole neck, so that on moving the head he cries out loudly. Pain in the nape of the neck as of a heavy weight like lead, preventing lying down. Itching on the neck, and on the forearms. The left shoulder feels as if paralysed; tensive cutting all over the shoulder-blade; a rolling, twitching, and s In organic affections of the heart, diseases of the valves, hypertrophy, &c., Rhus may be of some service altogether symptomatically, but only the above-named affections appear to us to suit Rhus, particularly the neuroses. PHARMACODYNAMICS. 155 constriction in some parts of the left scapula, and over the right knee; pain as from strong pressure with the finger on the left scapula; constriction of the skin over it; twitching on the side of the same; drawing from below upward, and pressure under the left scapula in the side of spine; drawing and pressure under the right scapula, confining the breath. Tearing between both shoulders, and constriction of both sides. Violent rheumatic pain between the scapula, affected neither by movement nor by rest, relieved only by heat, increased by cold. Shooting in the back; pressive, more when walking; also on stooping, yet more on rising up again; in the evening drawing in the back, must sit upright; disappears on walking. Constriction as if bound by a cord in the muscles of the back, less on leaning back, increased on bending forward. The loins feel sore while sitting, as if after stooping and bending of the back too violently. Pain as if bruised in the loins on lying or sitting still, not on movement; stiffness on movement; shooting jerks; on being grasped pain as if the flesh were beaten loose in the loins. On the right side of the lumbar vertebre, and on the loins as if bruised. Pressure as from the sharp edge of a knife when standing and bending backwards. Below in the loins, on the right, a burning spot. Weight and pressure as from a blow. Drawing, jerking shoots in the coccyx as with a needle. Tearing and drawing from the hip to the knee. On lying on the side pain as of soreness on the hip, and of the loins when lying on the back. EXTREMITIES. (UPPER AND LOWER LIMBS, THE JOINTS.) (S. 593-756, 766, 768, 773, 795). (Neuroses.) "(a) Spinal irritation. (b) Debility and palsy of the upper and lower extremities. (c) Rhenmatalgia. (cd) Neuralgic pains from over exertion, strains or sprains. (Affections of the Blood.) (a) Rachitic affections of the bones (caries). (b) Gouty affections (of the joints). Compare also the skin symptoms. Pressure on the right axilla, on the clavicle. From the axilla to the hand a feeling as if something rolled neither warm nor cold. Drawing under the armpit to the middle of the upper arm on lifting the arm. Swelling of the axillary glands, painful even when not touched. 156 RULES FOR THE STUDY OF Tearing in the axillary joint and in the upper part of the scapula; in both upper arms, worse when at work, during which the arms sink down; on pressing thereon pain as of soreness in the bones; tearing in all the finger-joints; violent in the arm, most violent on lying still. Drawing and tearing from the elbow-joint to the wrist; jerks in both, even during rest; in the thigh, a little above the knee. Tearing and drawing in the right groin down the thigh; from the hip to the knee; from the knee to the ankle; tearing in the knee and the tarsal joints, more when at rest; in the middle and outer part of the thigh when sitting, disappearing on movement. Pressure in both hip-joints at each step, and as if there was paralysis of the muscles of the thigh. Continued pressing pain in the sole of the foot, near the ball; on the right tibia, afterwards burning; crampish on the left tibia, while bending the knee, then burning and on the right thigh under the groin on one spot while sitting. Drawing shoots down the arms from the shoulders; fever in the limbs. Shooting, in the axilla, while lying, ceasing on movement; in the joints, when at rest, not on being handled, tearing in the left wrist; on the tibia with weakness; boring in the upper arm, thigh; violent in the right upper arm, as if it came from without; shoots as of needles in the left arm, soles of the feet, heels; burning under the left armpit, on the arms, back of the foot, between the toes; shoots on the back of the index finger in the tendons; in the fingers, in the thigh outwards; from the great toe to the middle of the left breast; in the ham-strings on violent movement; rising from seat, and handling; over the knee; in the left ankle-joints, and tendo achillis, as if with knives; in the outer ankle of the left foot; under the knee; on the inner side of both knees, shifting from one to the other; on the outer part of the ankle; in the heel, while sitting, after walking in the open air; while resting on the foot; by jerks in the diseased ball of the great toe, as if a boil was going to break out, in the evening shooting in it, fine in the toes; shooting outwards on the side of the knee; crampish in the ankle at the knuckle. Jerking feeling in the left arm; involuntary painless jerking in of both thumbs; in the thigh with trembling of the knees; in the calves. On crossing the feet feeling as of vibration in the shanks of the tibia, compelling him to move the legs here and there. Feeling as if hot water ran through the arms; in the points of the fingers; (in a warm room) as if distended with blood, while the back of the hands are cold. Drawing in the right buttock, immediately under the sacrum, disappearing, when pressure is made over it: in the knee; in the os femoris, compelling the patient to bend double; while standing up; in the ankle; upwards in the heels; burning drawing pressure in the great toe, with heat; drawing and tension in the right hip, in the calf, makes the foot restless; paralytic feeling while sitting; crampish drawing in the left elbow joint, on movement; in the right buttock; (crampish PHAIRMACODYNAMICS. 157 drawing of the finger;) crampish constriction on the inner side of the sole, while stretching out and bending the foot upwards it abates; of the toes; spasmodic drawing up in the left calf to the ham. Tension in the left upper arm in the open air; in the elbow-joint, while stretching out the arm, with difficulty in elevating it; in the hip joint while sitting; in the groin, as if the skin would not yield; on the back side of the thigh; drawing down the left thigh from the joint; in the knee, as if too short; in the knee-joint; in the calves, the ham strings as if too short; in the feet, with weight; while sitting, while walking, tired; with pressure in the soles; with shoots, and as if the skin was stretched up, in the calves. Tension with stretching of the ham-strings, exciting restlessness in the feet, with crawling. A painful throbbing in the left elbow. Beating and throbbing on the dorsum of the foot. Itching, burning, from the left elbow, obliging one to scratch, going away afterwards; violent in the hands; shooting in the left calf; in the ball of the left great toe; on the left ankle, and over the dorsum of the foot; violent (on drawing off the stockings) in the region of the ham-strings; scratching is painful. Burning, gnawing, in the right forearm, in the flesh between the thumb and the left index finger. Digging pain in the bones in the left forearm, during movement, and jerking in the right carpus. Stiffness of the whole forearm, of the finger, in the knees and feet. Disposition to stretch out the legs. As if bruised. Feeling of powerlessness in the forearm, in the fingers on movement; pain as of a sprain in the left carpus in the act of grasping any thing. In the upper part of the left carpus feeling as if sprained; in the upper part of the right thigh, inwardly to the groin, a pain like what is felt in a strain or sprain of the wrist; the foot feels as if sprained in the morning when stepping on it. Bruised pain and drawing in the thigh. Feeling in the left upper arm as if rubbed with woollen cloths, or as if it had been scraped with a knife, with a cold sensation in it. Coldness; cold sensation in the carpus, which has the natural warmth to the feel, as if a cold wind were blowing upon it, also on the left tibia. In the evening in the bad leg a pain for half an horn', throbbing and creeping, with a cramp-like pain, as in a whitlow, increased by motion, but worst under the touch. Cramp-like pain in the left buttock and thigh; in the calf while sitting, going away on rising up; in the calf after midnight when lying in bed, after walking, while sitting, going away while bending the leg. Trembling of the arm during moderate movement of the arm and leg. Deadness and numbness of the foot, with feeling as if it were made of wood. When stepping the heels feel as if swollen. The limbs, lain upon, go to sleep. The left index finger goes to sleep; index and middle finger numb. Creeping and numbness in the finger points; creeping and gnawing in the metacarpal joints of the fingers, in the feet. Buzzing in the knees and hams. While walking, weak in the 158 RULES FOR THE STUDY OF legs, heavy and bruised, which goes away after sitting; the legs are tired, as after a long walk; painfully tired in the legs while sitting, which goes away on walking; in the feet at the 'same time going upwards is difficult, as if one had been running much; as if the blood sank down into them; as if the legs were paralysed; as if a hundred weight were pressing on the hams and calves, with difficulty to bring the feet forwards. Heaviness in the legs, extending from above the knee to the lower tarsal joint, making it difficult for her to stand; this heaviness diminishes when walking, and is not felt on sitting. Cannot advance for stiffness. Staggering towards the right. Paralysis of the lower extremities. The fingers move with pain on account of swelling. The back of the head smarts and is hot; the skin is hard, rough and stiff. Hot swelling of the hands and of the face. Erysipelas, swelling, and pustules, with burning and itching on the arms and hands. Pain and swelling of the arms. Discrete, small, round, red spots on the forearm. Vesicles on the right wrist, on a blood red ground, always increasing from the size of a kneedle's head to that of a pea, which collectively appear to form a thick cluster, and appear shining and brown from the desicated moisture which exudes from the vesicles as clear water. A number of vesicles in the form of a bracelet, four fingers broad, round the wrist, exuding clear water. Hard pimples on the hand, with shooting, gnawing, itching. Inflamed blotch on the middle joint of the ring finger, with itching burning pain, sometimes passing over into a slow stitch; cannot be removed by friction and scratching. Pimples on the inner side of the wrist, and on the cheeks, resembling itch, which burn and itch and smart when scratched. Feeling of heat in the left foot. A red very hot spot with burning pain on the right hip, swelling of the feet, painless on being handled. Burning point at the inside of the right thigh near the testicle. Red, burning spots and streaks on the inner side of both knees, with small vesicles which soon dried up. Small red spots on the ball of the foot. Recurrence of the chilblains of the previous year, with burning throbbing; when not scratching there is pricking, after scratching, blotches. The corns smart and burn. A cracking for several hours in the right hand, between the thumb; in the outer side of the calf. Pinching on the back of the finger, on the outer part of the arm and on the head. SKIN. (S. 757-759, 761-764, 772, 774-788). (Neuroses.) Neuralgic affections, dependent on spinal diseases. PHAR.MACODYNAMICS. 159 (Affections of the Blood.) Exudation-formations, (a) dropsical; anasarca, (after ex-, anthemata, especially the dyscrasic). (b) Exanthematic; (1) dyscrasic, psoriasis, impetigo, herpes, especially of the face, tinea, lepra, gutta rosacea, rhagades, verrucae: (2) putrid; petechime, morbus maculosus, carbunculus, pustula maligna,, perniones; (3) albuminous, erysipelas bullosum and pustulosum; scarlatina, morbilli, variola, variolois, urticaria, pemphigus; all with nervous symptoms and disposition to decomposition of the blood. Swellings (encephalhematoma). Ulcera phagedoenica, gangroenosa. Creepings in the face, spine, sternum. Itching burning here and there; over the whole body, especially on the hairy parts; upon the head. Swelling of the hands and feet. A wound became inflamed and was set with small vesicles containing a milky fluid; some with a transparent fluid became confluent and desquamate. Eruption like nettle-rash. Burning eruption of small vesicles filled with water. Redness of the skin over the whole body, excepting the scalp, the skin of the palms and soles. Very painful violently burning itching eruption, especially on the scrotum, the prepuce, the eyelids, the eyes, (with swelling,) consisting of small yellowish vesicles, which run together and become moist, some as large as a lentil on the arms and loins, on being scratched getting very hot. Slow suppuration of many of these pustules, they have a red areola, are broader, heal slowly; the smaller ones dry up more rapidly and desquamate. Red spots of the size of the largest lentils, with small vesicles in the middle; on being touched by the juice two black spots on the index finger in an hour's time; twentyfive days after violent burning in the mouth and throat; speedy swelling of the left cheek, upper lip and eyelid; the night after great swelling of the forearm, skin becomes leathery, intolerable itching, great heat. After four days pustules on the hands and forearms, which burst and exude a clear moisture. Black pustules with inflammation and itching overspread the body in a short time. A black spot on the part touched with the juice. Scurfs over the whole body. The skin is made red by the juice, and like tanned leather; after some days desquamation. Creeping pains in the ulcers; smarting pain in the ulcers, as from salt, merely at night; in the day merely on going into the open air; shoots in the neighbourhood of the scurf; pain as of bruise in the ulcers; burning smarting therein, with weeping and moaning. 160 R1ULES FOR THE STUDY OF Compare here the exanthematic symptoms occurring in other places. SLEEP SYMPTOMS. (S. 817-876.) Agrypnia and sopor, generally symptomatic phenomena; compare specially febrile states. Yawning; in the morning frequent; as if sleepy; violent and spasmodic with danger of spraining the maxillary joint. Sleepiness in the day, even in the morning. Anxiety, restlessness, melancholy, dry lips; while sitting after walking. Disposition to lie down, weak and weary; cannot remain out of bed; on sitting up nausea. In the evening sleep suddenly comes on, not to be shaken off, all the limbs as if paralysed. Somnolent state, full of tiresome uninterrupted dreams. Late going to sleep and tossing about in bed. Great nocturnal restlessness; sleeplessness till midnight, with or without sweat; without heat; four nights cannot remain in bed. Cannot go to sleep; sweat without thirst; for great liveliness, insupportable heat, ebullition of blood, without thirst, throbbing. Appearances like thick clouds before the eyes; after midnight quiet and sleep. Restless, uninterrupted sleep, with much tossing on account of a burning eruption; tossing about, airing of the bed clothes, uncovering one's self, with nausea; full of vexations, unpleasant conceits and thoughts. On going to sleep pressure at the stomach, preventing sleep; dreams anxiously of business. Talking in sleep, in the evening, loud, half aloud, about the stories of the day, of business; will toss off every thing; longs after this and that; in the morning does not sleep again, and when he does, lively dreams of being awake, as if he had not slept. No sound sleep after midnight; restless tossing on account of unpleasant burning over the whole body, without thirst, with dreams full of anxious troubles and impulses. Dreadful shocks on going to sleep, as if he had let something fall. Jerking starts during the forenoon sleep. During the day's sleep restlessness, movements of the hands in sleep here and there, and playing with the fingers and hands. Loud crying in sleep. Sleep with open mouth. Anxiety at night, he would escape from the bed, seek help, on account of an indescribably unpleasant feeling. Great timidity at night, cannot remain in bed, as if something drove him out. Breath short, loud and thick, inspiration inaudible. Must lie on his back at nights. Unpleasant heat, without thirst. Frequent waking up at night on account of a nasty bitter taste, with dryness, in the mouth; thirst without desire to drink, with slimy mouth. Waking about midnight, on account of violent, pinching, digging up pain in the abdomen, with prostration and emptiness at epigastrium, and retching, which soon passes off. Dreams PHARMACODYNAMICS. 161 of circumstances thought of in the evening, or heard or transacted; of the accomplishment of projected ideas; of fire; fearful with palpitation while waking. After getting up confused in the head; on waking with convulsive movements of the limbs, shrieks on account of a tremendous headache, proceeding from a feeling of forcible drawing of the limbs; very vexatious, irritable mood on waking. FEBRILE STATES. (S. 878-942.) (Equal participation in nervous and sanguineous affections). (a) Intermittent fever. (b) Fever with decomposition of the blood and affection of the nerves; typhus (stupidus and versatilis); F. putrida; F. pycemica (especially in puerperal fever, tuberculosis). (c) Symptomatic fever with nervous (typhus) phenomena with local affections, especially catarrhal, rheumatic, exanthematic fevers of this nature. Shuddering on rising in the morning; in the back. Sensibility to the open, cool air, it even produces pain on the skin, although there is no repugnance to it: cannot get warm in cold air however much wrapped up. Chilly shivers, with violent thirst, mucus within the lips; feet icy-cold, not to be warmed in the evening in bed, the rest of the body warm. Extremely cold hands and feet the whole day; inward feeling of cold in the limbs, as if they were dead or asleep, but no external cold. Chilliness in the house towards evening; fugitive chills, with dry lips and little thirst and hunger; continual chilliness; in the open air without thirst; shuddering chill on coming out of the open air into the warm room, without thirst; in the evening, in the house, with throbbing toothache and accumulation of saliva, without thirst; in the open air shuddering chilliness, becoming still worse in the warm room, and even at the hot stove, with violent thirst and ceasing of the flow of saliva; the chilliness loses itself only in bed, though the thirst remains, then stupid sleep, with tightness and confusion of head, going away after rising. In the evening external cold and chilliness, without shivering, no coldness to the feeling, not cold inwardly, can bear cold drinks; immediately after lying down external heat, without thirst; moist mouth, dry lips. About midnight some moisture on the skin during a half slumber, afterwards sweat in the face, hairy scalp, neck to the chest. Shuddering and heat at the same time, without thirst, after taking a walk, then somewhat warmer. Sweat over the whole skin, MI 162 RULES FOR THE STUDY OF especially in the palms of the hands. Inwardly hot, outwardly cold, warm to the feeling, and without particular thirst; coffee increases the heat. Pinching cold in the feet, between the shoulders, then much outward heat, burning in the left arm, and on the left side of the upper part of the body, with redness of cheeks. In the evening chilliness and heat, the face seems hot, but the cheeks are pale and cold to the feel. The breath comes hot out of the mouth. Fever with convulsions, and evening fever with diarrhoea, chilliness, then in bed for several hours dry heat, with much thirst, cutting in the abdomen as with knives, diarrhoea in the heat, then sleep, then again diarrhoea. On the following evening diarrhoea again, chilliness for one hour through all the limbs, without thirst; then dry heat, heat with violent sweat, three hours long with thirst; merely mucous diarrhoea, with violent cuttings in the bowels, tenesmus, headache, pressing from both temples towards the mesian line, congestion of blood and heat in the head. In the forenoon sleepy weariness, yawning, as if before going to sleep, while walking, with anxiety; stool, with cutting; immense heat in the whole body, without thirst; shuddering, as after warm water had been poured down, or as if hot blood were in the vessels and head, and as if the head were pressed down, obliging him to stbop, with throbbing headache; in the evening chilliness, as if cold water were being poured over him, or as if cold blood were in the vessels; after lying down and being covered up, heat; at night drawing in the spine between the shoulders, and in the limbs, as if he should stretch himself constantly. Early in the morning sweat. Towards mid-day febrile chilliness in all the limbs, with headache and giddiness; in the evening chilliness again; he has to lie down; at night sleeplessness, giddiness, and sweat. In the afternoon stretching in all the limbs, shuddering, thirst, with cold hands,, heat and redness of the face; in the evening in bed shivering; in the morning moisture over the whole body, with pressure over the temples; in the afternoon general warmth, with heat of the head, both internal and external, and shuddering, without thirst; stretching, drawing weakness, in the limbs. Headache, as if the head felt oppressed and the sides of the occiput were pressed together; violent cough, with short breathing and pain in the throat, as if the tonsils were swollen - towards morning the whole body was covered with a slight moisture. Heat on the left side, cold on the right side, without chilliness; heat on the other parts of the body; over the head and back chilliness. Cold shivering through the sweat, with cramps in the abdomen at night in bed. Inclines to vomit, with heat of the head and hands, and chilliness of the rest of the body; afterwards chilliness all over after retching. She feels hot to herself and others, with distended veins, and a weakness which compels her to support herself. Violent thirst; the day after shuddering over the upper part of the body, especially the arms. Heat in the face and PHARMACODYNAMICS. 163 fingers, with chills in the scapula, without thirst. In the evening inward heat in the forehead and head, extreme heat in the hands, with dull headache. Heat and sweat after and while walking in the open air. Violent burning in the skin, with twitches; general sweat; cough. Sweat over the whole body, not in the (hot) face-in the morning gentle, round the neck, all over the body with the exception of the head, without smell, acrid, sour, without producing weakness, on both legs, at night, in the morning, daily, with cold sweaty cheeks. Heat and great thirst; thirst, especially in the morning, at night, strong, for water or beer. Absence of thirst. Pulse slow, sometimes irregular, quick. PSYCHICAL STATES. (S. 943-976). (DEPRESSED STATES.) (a) Melancholia. (b) Hypochondriasis. Amentia. (c) Stupidity. (d) Amnesia. For the citation of the particular states see above A, where also what remains further to state about the general appearances, state of the strength, &c., are contained. M 2 EXAMPLE FOR THE COMPARISON OF, MEDICINES WITH ONE ANOTHR 168 RULES FOR THE STUDY OP may in most points agree, yet that one or the other presents such a difference, that the recomposition of the whole produces a new sharply defined individuality. The field of Pharmacodynamics will in this way be carefully ploughed up, repetition gives firmness of grasp, and comparison sharpens the sight. If we take, for example, Bryony, whose actions we have learned, and imagine to ourselves that the learner has jumped on some stages, where he is already at home in the Materia Medica, a comparative review of the analogues of Bryonia will be of great use. (We omit here the comparison of Bryonia and of Rhus, which may be almost spontaneously made from the very minute characteristics given above, for the sake of avoiding needless repetition.) In the Materia Medica of Noack and Trinks a long list of the medicines related to Bryony is cited, which show naturally a higher or lower degree of agreement. To this class belong (1) Aconit., Ammon., Ammon. muriat., Berberis, Chin., Clemat., Colocynth, Led., Lycop., Mercur., Phosph., Puls., Rhus, Senega, Squill. (2) Alum., Am., Ars., Baryt., Bell., Boyist., Cham., Cin., Coff., Dros., Dulc., Graph., Hep. sulph., Ignat., Kal., Lach., Magnes., Moschus, Mur. ac., Nux v., Op., Ran. bulb., Rheum., Ruta, Stram., Sulph., Thuj., Verat. (3) Calc., Caps., Nit. ac., Selen. We are about to compare the first named eight of these medicines with Bryony to make ourselves aware of this relationship, and in this way to reflect a clearer light on the individual medicines themselves. Aconite has in common with Bryony the action on the vascular system, the mucous, serous, and fibrous membranes, the external skin, the secretions of the liver and gall-bladder, the lungs, the urinary and sexual organs, the muscles, the articular apparatus, the periosteum, and on the nervous system of the sensational sphere. It affects likewise the circulation, and induces plastic consequences, which constitutes it the most powerful medicine in fever and inflammation. The pains which Aconite induces are drawing, drawingtearing, shooting, pains like those from a bruise, especially PHARMACODYNAMICS. 169 of the joints; it causes besides weakness, faintness, &c. The sufferings become worse in the evening and in the open air. The special cases in which Aconite and Bryony are employed run much together. These are congestions, haemorrhages, (nose, lungs, rectum, uterus,) inflammations, (of the eyes, intestines, respiratory organs, serous fibrous membranes, mucous membranes,) muscular and articular rheumatism, acute and chronic gout, spinal irritation, neuralgias of particular nerves, exanthematic fever, (roseola, morbilli, miliaria, variola,) catarrh, rheumatic, typhus fever, intermittent fever, bilious states, (fright and vexation, icterus,) hepatic affections, &c.; and consequently both medicines differ in this, that in Aconite the arterial, sthenic character predominates, every thing bears the stamp of the active, synochal, stormy; whilst Bryonia answers more to venous and irritable, mixed with sensitive, erethistic states. Aconite is, to speak for once after the manner of Vogt, the male, Bryony the female principle of the circulation. The former consequently requires the full strength, the first, forcible, determined onslaught of inflammations, fevers, and similar states; the latter suits rather the resultant and transitionary states. Ammonium carbonicum shares with Bryony the shooting, tearing, drawing, the pains of sprain and ulceration, &c., the sensitiveness to cold and the open air, the influences of a sedentary mode of life, the relation to the female sex, the excitability, the venous constitution, the congestion to the head with pressing outwards at the forehead, with nausea, the ophthalmie, the dysecoia, the epistaxis, odontalgia, cardialgia, colic, gastric affections, obstructions, anomalies of menstruation, night-cough, hamoptysis, asthma, eruptions, rheumatic gouty affections, weakness of the limbs, restless sleep, dreams, excitement in general; and yet "wide as the poles asunder" is this medicine from Bryony in its fundamental asthenic diathesis, in its disposition to decomposition, to colliquation, out of which all these indications take their rise. The excitability is here totally devoid of energy, it 170 RULES FOR THE STUDY OF depends precisely on torpor and dissolution. There we see irritability of an active kind, here adynamia, which in its last flickerings still bears the appearance of life. Consequently Ammonia suits in lymphatic constitutions, in all asthenic fevers, with chest affections of the same kind, in chronic affections of the lungs with suppurations, in gangrene. We may add as a special indication, which fails in Bryony, that heat relieves the symptoms of Ammon. carb. Ammonium muriaticum agrees with Bryony in particular relations only, particularly as regards the kind of the pains, the mood, (but especially melancholy,) the weakness, heaviness of the limbs, the congestive exanthematic character, the relation to the mucous membranes and glands, to obstruction, to cough, &c. Even a superficial observation, however, will soon teach us that the metamorphoses within the capillaries are of a different character, and that the tendency to the mucous membranes is constituted in quite a different way from that of Bryony, as well as that the sphere of action proceeds within more defined restrictions in Sal ammoniac than in the more deeply penetrating elements of our medicine. The same is true of Berberis, which likewise on the side of the lower metamorphoses attacks certain points of the organism, which apparently stand a degree deeper in importance. A primary action on hemorrhoidal affections, urinary diseases, and anomalies of menstruation, are predominant here, an action which fails in Bryony. Besides this, the pains, the feeling of prostration, the aggravation in movement, the symptoms of the joints, bones, tendons, (lymphatic swellings,) muscular system, the fibrous parts in general, the liver, skin, a predominant direction to the venous system, to the mucous system, (of the eyes, of the gastricointestinal canal, of the urinary organs, of the genitals,) the biliary system, -lastly, the catarrhal, rheumatic, gouty elements, are all quite adapted for drawing interesting parallels. The affections of Berberis are worst in the afternoon. PHARMACODYNAMICS. 171 China, on the contrary, agrees with Bryony rather in the points of exit of the nervous and vascular system, and has certainly a surprising similarity with it as regards the kind and seat of the pains, the aggravation by movement, touch, at evening and night, in the open air, the stiological elements, (anger, chill,) the relation to the female sex and the clinical applications, (for example, congestions, hmmorrhages, catarrhs and inflammations, fever, dropsies, rheumatism, gout, gastric, bilious states, &c.). But the fundamental character of China is not irritability with increased sensibility induced by real elements of excitement, but precisely by states of debility. States of depression are present here, although they appear outwardly as exaltation. The paralysed central parts lose their influence, the uncontrolled material elements accumulate, decompose, and thus excite commotion. Consequently the psychical mood in China is different from that in Bryony; consequently the principal setiological elements are here:-debility, all kinds of loss of fluids, their irritations; consequently in China prevail tremblings, jerks, internal restlessness, paralytic feelings; consequently the vasomotory activity loses its contractive power, and passive congestions, haemorrhages, mucous discharges, asthenic inflammations, slow fevers, scurvy, consumptions, effect an entrance. Clematis has only a remote similarity in the kind of pain, the articular rheumatism, the glandular affections, megrim; but the fundamental character is that of torpor and of cachexia; the reproductive is the principal sphere, (consequently tooth-ache in hollow teeth, scrophula, chronic exanthemata); and as a psychical element, melancholy is predominant. Colocynth has also on a closer examination only some particular elements related to Bryony, particularly as regards the neuralgias of the trigeminus, the affections of the joints, especially of the aponeuroses, the ligaments, the swellings of the external parts, the venous, bilious, rheumatic, and gouty affections. By way of distinction we must content ourselves RULES FOR THE STUDY OF with pointing out the jerking, the cramp, the constriction, which predominate over the other kinds of pain; the stiffness, weakness, cramps, faintings of Colocynth, the oppression, the sthenic character of the reaction on the other hand, the specific relation to hmemorrhoidal affections, to dysentery, to coxarthrocace, ischias, &c., and the aggravation of many troubles also during rest, and the relief from passing flatus. Ledum has a special relation to the brain, to the organs of respiration, the lymphatic vessels, the secretion of urine, the external skin, the serous and fibrous tissues, the muscles, bones, and will coincide in many points of view with Bryony, with which Ledum has in common the moral state, the head congestions, the rheumatic and gouty elements (of the joints especially), the hydrothorax, hwemoptysis, exanthemata, &c., as the aggravation by movement and the nocturnal exacerbation. But though among the sensations the predominant jerking, the incapacity for bearing the heat of the bed, and aggravation through heat in general, present remarkable differences, yet the principal feature in the action of Ledum, namely, the decomposition in the blood and the want of internal vital heat, is much more decisive. From this the action in hmemoptysis, consumption, hydrothorax, &c., is abundantly explicable. It would lead us too far, if we went on in this way, to subject all the medicines which have been arranged as related to Bryony, to a specification. It is easy to see how these affinities can be considered in a more or less extended circle. And in fact Bcenninghausen has cited as "concordances" of Bryony, in addition to the above mentioned numerous medicines, these that follow besides: Hyoscy., Nat. mur., Sep., Aur., Canth., Carb. v., Caust., Con., Creos., Petrol., Phos. ac., Plumb., Sabad., Spig., Staph., Zinc., Asafoet. Mezer., Silic. Arg., Cupr., Cyclam., Rhododend., Sabin. Ant. crud., Cicut., Spong., Viola tricol. Ant. tart., Croc., Nux moschat., Dig., Fcrr., lod. Coccul., Colch., Stann. It is easy in this way to draw in the whole Materia 174 RULES FOR THE STUDY OF PHARMACODYNAMICS. only symptomatically related agree merely in some groups of symptoms." " Particular families which are especially adapted for comparison are, for instance, Nux, Ignat, Puls., Cham., Coff., Caps., Ambr.; further, Ars., Verat., Ipec., Am., Ferr., China; probably also Staph. and Sulph. ac., Sulph., Calc., Lyc., Led., and in another view, Theridion. One of the most remarkable and beautiful families is Hep., Mere., Bell., Lach. Between this and the analogues of Ars. stands Phos. ac. and Carb. veg., with their analogues; likewise Cup., and in another direction, Aur. A rich store of knowledge is created out of such comparisons like those beautiful crystalline deposits which are formed when you suspend a crystalline salt in a saturated solution of the same salt." (Compare C. Hering-iiber d. Stud. der hom. Arzneimittell. Arch. f. hom. Heilk. xvii, 1, S. 105-108). From the same esteemed physician had already proceeded (see Arch. xi, 3, 80,) Contributions towards the institution of comparisons between similarities and differences. Further, (Arch. xiii, 2, 1,) A Survey of the whole field of Medicine, as a preliminary attempt by way of guide to future inquiries, which lays before us much to encourage and stimulate us in the way of increasing our medicinal treasures and confirming our symptoms. Highly to be recommended also is Hartlaub's Contributions for the comparison and characterisation of several remedies in regard to their pathogenetic peculiarities, as of Nux, Ignat., Puls., (Archiv. iv, 1, 3,) and Watzke's Comparison of some remedies with Nat. mur., (Oestr. Zcitsch., iv, 1, 198,) &c. Ieil's attempt at a division of medicines according to their action on systems and organs, composed to facilitate their study, valuable as it is in itself, yet gives but one side, and is therefore not sufficient. 177 APPENDIX. MyV intention in this Appendix to the foregoing translation of Hirschel's Rules for the Study of Pharmacodynamics, of his Examples of the independent Examination and Treatment of Medicines (selbst-bearbeitung), and of his Examples for the Comparison of the Medicines with one another, is to supply briefly from other portions of his admirable work, such information as may tend to throw light on the selection of remedies for any particular case of disease. The indications for the choice of the remedy are, he says, taken, (1.) From the complex of the symptoms of the disease, with a special distinction of the primary, idiopathic, pathognomonic, and diagnostic signs. (Diagnosis). (2.) From the systems or organs affected. (The anatomicophysiological basis). (3.) From the diseased process-its nature, history, and duration. (The physio-pathological basis). (4.) From the internal etiological elements lying at the root of the disease, (the proximate cause,) so far as this is to be ascertained; as well as from the external exciting causes, even when these are to be sought for at a great distance, (for example, in chronic diseases, dyscrasic affections). (Etiology). (5.) From the peculiarities of the diseased individual in relation to age, sex, constitution, temperament, psychical peculiarities, mode of life, &c. (6.) From the peculiarities of atmospheric and telluric relations in regard to weather, temperature, period of N 178 APPENDIX. year and time of day, prevailing endemics and epidemics. (7.) From the particular modifications which external and internal influences, such as movement, posture, the open air, mental exertion, particular functional acts (eating, drinking, &c.) call out in the symptoms of the disease (and of the medicine). In the words of the author's admirable summary-" The similarity which ought to obtain between the medicine and the disease, is principally to be recognised in the symptoms which were predominant in the proving of the medicine on healthy persons, and in those essentially belonging to the disease. It must not only, however, extend merely to these outward signs, but there must also be a relation of similarity (agreement) and specific conformity of the particular medicine to the seat, the process, the internal and external conditions and causal relations of the case of disease, so that the peculiar character of the medicine may exactly correspond to the peculiar nature of the disease." In comparing the symptomatic treatment of the old and new school, the author begins by stating that the therapeutic school distinguishes three indications in the plan of cure(1) the indicatio causalis-the object of which is the destruction, removal, or controlling of the cause of the diseased state; (2) the indicatio essentialis, which takes in hand the most essential process in the case of disease, as the one, on which all else depends; and (3) the indicatio symptomatica, which only attempts to remove or moderate particular troublesome symptoms, to obviate intercurrent accidents or casualties, and to oppose dangers arising from a complication of relations. It receives its full justification from the fact that in the greater number of cases danger arises rather from secondary and tertiary disturbances, than from the essential process. It is to be considered, permitted, or demanded, (1.) In diseases which get well of themselves. (2.) In troublesome or exhausting symptoms. APPENDIX 179 (3.) Where a particular symptom only loosely connected with the principal disease prevents the cure, or impedes' the employment of the suitable remedy. (4.) In dangerous secondary disturbances, dangerous to life (indicatio vitalis). (5.) In all incurable diseases. (6.) When death is impending. (7.) In uncertainty about the diagnosis, where careful sounding by means of symptomatic treatment is possible and allowable. On the consideration of these principles, which characterise the whole allopathic art of healing, we begin to perceive the advantages of the new school. These consist (1.) In this, that the three above cited indications in great measure come together in the homoeopathic mode of treatment, and therefore present this, even in the sense of our opponents, as a rational mode of treatment. (2.) In this, that the symptomatic mode of treatment of the old school is quite different from the observation of symptoms in hommopathy, which offers no points of comparison with such mere empirical courses of procedure; and (3.) In the fact that it is rare indeed that anything answering to the allopathic " indicatio symptomatica " occurs in homoeopathic practice, and always then with much surer guarantees for its successful attainment. As for the plan of experimentally feeling one's way in a doubtful case, we can always spare ourselves this trouble, as our whole system of therapeutics rests on a much surer basis. On a strict inquiry into the cases as they occur, we shall find that it is especially in allopathy that the pure symptomatic treatment has the greatest extension, being by no means limited to the cases in which we also have recourse to it, that is, when the diagnosis is uncertain, (7th point,) or for palliation (points 1 to 6). 180 APPENDIX. We would ask each allopath on his conscience how often it is possible to bring forward the indicatio causalis, or essentialis, and how often with the best will and the most extensive knowledge, the most acute diagnosis will enable him to advance against the causes and the essence of the disease? The symptoms of the disease, the external signs, are as necessary for diagnosis to the adherent of the old school as to us. But too often he believes he is taking measures against the disease, while he is striving symptomatically against some of its component parts. His reasoning has deceived him. When, for instance, he diagnoses a dysentery, and from its fancied essence deduces the usefulness of an opiate, which, however, only checks or removes the tenesmus or the diarrhoea, without touching the essence of the disease, the treatment is not causal, or essential, but only symptomatic. It would not be difficult to shew in the same way that most of the allopathic cures are in this sense only symptomatic. The employment of Chloroform in neuralgias, of drastics, acrids, of cupping-glasses, of irritating frictions in amenorrhoea, of resolvents, Aloes, &c., in habitual constipation, of Digitalis, of Squills, in dropsy-do all these refer to a cure which has anything to do with the essence of the disease? Both schools need the knowledge of symptoms. It is the mental process with these symptoms that divides the schools, involving as it does a different mode of apprehending and employing them. The allopath creates out of these symptoms a diagnosis of the disease, from this all peculiarities are excluded, and a medicine antagonistic to the presumed essence, or the so-called proximate cause, is chosen. The homceopath treats also the symptoms as constituent parts of the picture of the disease, as means of diagnosis, but he does not forget the one for the other; he retains fast hold on them (the symptomn) as pointers for the choice of the medicine, because they objectively hold up before him by their peculiarities the special nature of the disease, through the whole process of subjective composition; whereas the allopath forms for himself such a nature subjectively, and therefore gives up the objective basis. The result is con APPENDIX. 181 sequently the most opposite. The mental process of the allopath leads through a necessary fiction, on the one hand in consequence of a defective knowledge of remedies, on the other precisely in consequence of an abstraction from symptoms, but too often to a symptomatic treatment, since the "rational" relations at his command are not sufficient. The process of the homoeopath, on the contrary, gives, through the use of the symptoms, an objective presentation of the picture of the disease, which in its totality leads to an essential and real cure. The symptomatic mode of treatment takes note of individual symptoms, or symptoms only as such, without mental analysis, valuation, or connection; processes to which the new school applies itself with especial diligence. The principal thing, the thing to be known with it, is not the symptoms, but the essence of the disease in all its relations; but to the symptoms, inasmuch as they are the best means for arriving at the knowledge of this essence, and for the determination of the morbid relations, it attaches a particular value. They are the means to their end, and the basis of their observations. In these outward signs the inner type of the disease is mirrored; in their totality they must contain the constituent and characteristic parts which compose the whole. From the phenomena coming out to observation at the surface, we must conclude on the internal causal relations, the very thing the homceopath does, since he does not stop at observation alone, at the mere appearance, as a child does, but proceeds to combine, to determine, and conclude. He, too, forms for himself a diagnosis of the disease by the separation of the essential from the non-essential; he, too, distinguishes primary and secondary, pathognomic, sympathetic, &c.; he, too, estimates the etiological element as the external constituent; but he never loses the objective actual substratum in the subjective, mental product which it has created, and thus, holding his ground fast, he is not exposed to the uncertainties of a wild goose chase. Hence the same individual signs in their connection are serviceable to him for comparison with the symptoms of the artificial medicinal disease, which he now 182 APPENDIX. proceeds to combine and determine on, as he did before with those of the natural disease, for the purpose of obtaining a corresponding type of artificial medicinal disease. The more striking the correspondence of the parts, the more exact that of the whole to the whole. But this must not be the result of a mechanical covering of one part by another, but of a judicial comparison, a separation, a synthesis, depending on the finest analysis; or a merely external, formal, not an internal, essential resemblance, would be attained. Every attempt at finding a resemblance requires reflection, if this is not to be founded on mere externalities, but is to signify a true internal affinity and agreement, such as we need. Wunderlich* in his Examination of the Rules of Classification, reviews seriatim the particular criteria of homceopathicity, which he styles essential, or illusory and accidental. With regard to similarity in external phenomena, he asserts, justly, that affections the most different as to causes, antecedents, and internal changes, may appear similar, for superficial symptoms very often depend on non-essential concomitants. A supposed similarity of cause may often bring together affections of the most different form, for we have generally only an imperfect and partial knowledge of the causes of disease, and a portion of the cause escapes us, and is not taken into consideration. A similarity in the changes of the most essentially affected organs would give the most natural ground of classification, if we only always knew the essential changes and did not so often take accidental or consecutive disturbances for them. Neither the symptomatic, nor the etiological, nor the anatomical element is therefore alone and by itself sufficient. On this account we cannot dispense with either of them; but we are often compelled, in the failure of other guides, to hold on by the symptomatic external similarity of the form of the disease. These criteria are available as to the homeopathic principle in the treatment of disease, and we may consequently apply the whole of this decision with unimportant clhau c to the law of similia similibus. "* Page 62. 184 APPENDIX. Crampy constriction, distension in jerks. Crampy tension, forbidding the slightest movement. Pressive shooting pain in theumbilical region. Straining and grasping about the umbilicus, obliging one to bend forwards. Pressure as from a heavy weight. Violent noisy borborygmi in the abdomen. Feeling as if a hard body pressed outwards towards the inguinal ring. Colic, as if all the intestines were tied up in a knot. Painful pressure in the 'neighbourhood of the coecum. Flatulent rumbling and pinching. Borborygmi in the abdomen. A feeling in the left groin, as if a hernia was going to appear. How similar are these symptoms, and yet how different is the application of these remedies according to the signification of these symptoms! Indeed a case may occur in which the symptoms may appear more like those of Veratrum than those of Belladonna, and yet the latter be the medicine, for Belladonna answers to inflammatory rather than spasmodic colic, Veratrum the reverse. And indeed the symptoms of a peritonitis may resemble those of Veratrum, and yet never yield to it, for though the character of Belladonna does answer to a peritonitis, that of Veratrum never does. A more exact comparison, a deeper insight, a taking into account of several elements, are necessary, in order to base a specific relation between the medicine and the disease, in order, in each individual case, to find out what is suitable and indicated. But we must now proceed towards the objective inquiry which presents to us the observable phenomena. Review of the anatomical element, the locality. The anatomical element, the locality, deserves a special consideration. Pathology, from the time she began to follow out diseases from their local points of origin, and to pay special attention to the anatomical basis, has taken a new start, and has, in consequence, to a certain extent, the first title to the name of physiological medicine, a title, however, to be fully earned only by her labours in the APPENDIX. 185 future. Physiological medicine also cannot escape treading this path, if she means to attain her principal indication, that of individualisation. Since each organ possesses its own peculiar life and its proper or individual kind of activity, the knowledge of the specific relations of medicines to particular organs and to the functions they derange is a great step to -the comprehension of medicinal action in general and to treatment. We oppose to the disease seized in its point of origin and its first element of development, the locally acting medicine-the contending parties touch equally on one and the same ground, a direct mutual action must follow. Besides, the anatomical basis gives also the conditions for certain forms and alterations of the diseased state, which are of more or less general influence in proportion to the extent, the properties of the different structures and tissues, and the connection these tissues have to the others. We deduce from the structural basis certain general laws of disease, and apply them to the respective localities. For example, we know that inflammation has very different terminations as it occurs in the serous and the mucous membranes, and we turn this knowledge to account in pleurisy, pericarditis and gastro-enteritis; or we make use of the unity of the catarrhal process, which as a congestive process depending on the peculiar structure of the mucous membrane, runs a very similar course, whether it attacks the bronchie, the stomach, or the genito-urinary system. The question of first importance is the enquiry as to the sphere of action which the medicine has, or to speak strictly, the question as to the locality, that is, as to the organs affected. We must first know whether a medicine acts on the heart, lungs, bladder, brain, &c. In this way we attain at once a certain, although a general knowledge of the physio-pathological processes, which become developed in one or more large portions of the organism, and are affected and altered by the medicine. In general several organs are affected by one and the same medicine. We then put the further question, what particular parts of these organs are particularly affected by the medicine, and we deduce therefrom an affinity-it 186 APPENDIX. may be-to the mucous membranes, the lymphatic system, the capillary system, the venous branches. If we know that "a medicine has a decided action on an anatomical system or "a particular tissue, we have attained a certain amount of knowledge as to the physiological characteristics of the medicine, secured to us by a certain regularity running through all diversities of place. We attain, to express ourselves with more precision, a more exact comprehension of the type of the medicine's action; for we know not only the influences upon the organs of the body as such, but also the changes produced on the more remote elementary portions of the organs, and of the whole body. We then see why the same medicine acts alike in different parts of the body, and have opened out to us a comprehension of the relation of the medicine to the morbid process essentially dependant on the anatomical basis. For this reason, if the inquiry as to what organs a medicine affects is of paramount importance for the determination of its functional activity, since the organs or groups of organs present functional unities or groups, not the less pressing is the inquiry as to the elementary structures over which a medicine extends its influence, whether on the vegetative, (the membranes, the ligaments,) or the animal, (the nervous and muscular systems,) or the general substratum in the deep back-ground of life, (the lymph, blood, and cellular membrane). This shows partly the internal antecedents of the functions, partly gives us a solution of the formal changes presented by structure, which come especially under consideration in diversities of the morbid process, in which both the functional and the material play an equally important part. To recapitulate, it is of the first importance to know in what organ the disease has its principal seat, since the functional changes and the symptoms which manifest these are regulated by this. We have then to distinguish what elementary tissues are affected, and ascertain their structure. Hlypermmia presents us a clear example. The relation of APPENDIX. 187 the locality, of the histological basis to the kind of degeneration, is nowhere better shown than here:-an inflammation in the lungs will excite quite different symptoms from one in the stomach, and will also, as it selects the mucous membrane, the parenchyma, the veins or the capillaries for its seat or terminal point, present great differences of form, though the process itself remains unaltered. The researches of Berres* as to the arrangement of the smallest arterial and venous twigs in the capillary system, have shewn the way to place the hyper-emime on the most special local basis. According to these, great differences arise from the ultimate form of the ramifications-for instance, the linear, vascular tissue in the muscles, which has little tendency to become hypereemic; the longitudinal of the nervous substance, which permits a rapid flow to and fro; the longitudinal meshy tissue of the fibrous membranes; the dendritic in the serous; the radiating vascular plexus in the glandular organs; and the erectile tissue; from whence the more or less easy occurrence, the intensity and duration of the hypera~mime may be anatomically explained. Not less, important are the anastomoses of the capillary arteries with the capillary veins in the simple meshed flexus, in the connecting meshed flexus (muscles, nerves, fibrous membranes), in the encircling meshed flexus (glands, lungs, cortical substance of the brain), in the looped vascular net, looped formations (organs of the senses, papille of the tongue, the pylorus, the small intestines, the papille of touch, the genitals), in the looped meshy tissue (serous membranes, corium, mucous membranes). Examples of local specification. This knowledge is as important in pharcodynamics as in pathology, and it cannot be a matter of indifference to proceed beyond the knowledge of the specific relations of the remedies to the organs, to win our way by comparison and * Berres' Anatomie der Mikroskop. Gebilde des Menscli. K. S. 36-70, und Wunderlich's Auwendung auf die Pathelogie, S. 354. APPENDIX. 191 brain? the spinal marrow (sensational or motor fibres)? ganglia? the vascular walls? arteries? veins? the capillaries of a parenchyma? the blood itself? But to get at these ramifications we have to ascertain the central point, from which arise difficulties, only to be overcome by a logical presentation and development of the type of the disease. From what has been said it is clear, that (1) together with the so-called general action, a special and peculiar one upon one or more points is possible, which may be (a) either the cause, or (b) its consequence; and (2) that, in particular, proceeding from one organ, for example, the heart, the lungs, the liver, an action may be produced on the blood or the nervous system, which, in their turn, excite reactions. On applying these observations to the laws of healing, we observe that a local disease can be as well met retrogressively by a medicine of general action, as the healing of a general affection can be brought about by the treatment of a particular part. The part which this relation of locality plays in the different schools of medicine, exhibits their difference in a strong light. In allopathy, where the local action of a medicine is ascertained only by its use in disease, the reference to pathology is loose. In consequence of the predominance of the use of general means according to dogmatic categories, and of the prevalence of so-called general methods, local reference is the exception (Wunderlich, indeed, calls it a delusion to expect advantage in therapeutics from localization in pathology), it frequently coincides with topical (external) or symptomatic action. Since allopathy chiefly acts by antagonism, by exciting the secretions, by derivatives, by quantitative and chemical means, but especially by acting on the constituents of the blood (alteratives, resolvents, diluents, corroborants), with a dark instinct in the ways of humoral pathology, and by massive doses takes the whole system into its hands, this ignorance and neglect of the local peculiarities of their medicines does not work them so much harm as might have been expected, but confessedly deprives them of the advantages of a direct mode of cure. 192 APPENDIX. Rademacher, on the contrary, places, with justice, a great value on these localizations; but, alas! only too great a value, since the protestations of his disciples to the contrary notwithstanding, he undervalues quality, and creates artificial distinctions, as the categories of medicine, the only objects of his therapeutical investigations, fully show. On finding these localizations he has an indication for practice. His division into medicines for organs, and for the general system (wrongly styled by Kissel medicines for the blood), is only of service in so far as it helps to a selection of one of them, or indeed to an addition of several out of one, or a combination out of both classes-a two-fold division which is both logically and physiologically untenable, in consequence of the difficulties in distinctions and separation, as Kissel himself confesses; the complexity of intercurrent symptoms, and the interchange of organ and blooddiseases, and this without reference to the fact that the action of the nervous system or of the blood on an organ is quite overlooked, though this may be local. We do not consider therefore that Rademacher has made any important advance in practice, for in truth, in spite of Kissel's excellent requisition for a deeper physiological basis, an observation of the diseased process, a semeiotic valuation of the morbid symptoms, of the relations of a humoral state, &c., these are less in question than the anatomical basis; and, moreover, in the attempts after the origo mali, the complex, the type of the disease in general, a point with us of the highest importance, runs a great chance of being overlooked. The so-called inductive method, by which these artificial categories have been discovered, is also in the highest degree exceptionable, and is nothing more than making the healing art a blind groping with no better guide than chance. If Copper and Iron are medicines acting on the general system, as trials in diseases considered general teach us (these are generally epidemics); and if Copper:and Iron, again, cure a pneumonia, as trials in disease again teach, is pneumonia therefore a disease of a general character? In this way pathology will be dogmatically enriched by therapeutics, and 194 APPENDIX. Out of this neglect of the material side of medicinal action may be deduced the imperfect observation of the chemical element, as well as the predominance of subjective phenomena over objective changes, which is observable in the homaeopathic Materia Medica, which, in this relation, presents great deficiencies. The word " dynamic," in particular, has led to great misunderstanding, and is, in many respects, a cloak for obscurity or the want of scientific knowledge. Sometimes it is used to indicate force in apposition to matter (and in strictness this is the right meaning); sometimes it is used in a more restricted sense for the manifestation of action (function) in apposition to modifications of the fluids and form; sometimes to phenomena occurring in time rather than in space; and in its most special anatomico-physiological relation, for the activity of the nervous system in apposition to the life of the blood and of the organs. At all events, however, an exclusive predominance of one sense, whatever this may be, without the participation of the other, must always be unphysiological; since both apparent opposites, in consequence of the unity of life in organic nature, as also in the phenomenal world and the laws of inorganic matter, run into one another. On this ground it is incredible that Hahnemann meant by his dynamism to exclude the material participation of medicines. Such an observer could not have overlooked the fact that certain medicinal substances, his own antipsorics in particular, have a very decided material sphere of action, since his doctrine of psora and of the other dyscrasias, took precisely the state of the sanguification for its principal basis. Confessedly, however, the matter was looked at in the most general way. To come to particulars with the changes in sanguification, brought about by medicines, was not thought worth while, from the dynamic point of view; and it has been only of late that men have begun to turn their regards on the material side, as is observable in the Materia Medica of Noack and Trincks, or in the allusions made by Franks to Mitscherlich's PPEND'ix. 195 excellent researches into the action of medicines on the blood (Arch. xvi. and xvii.), Arnold's trials with Phosphorus, Aeon., and Bry., &c., and the notice which the labours of B3cker, Beneke, &c. in this field, have attracted among homceopaths. There is greater difficulty, however, in inferring, from trials on healthy persons, made with large doses, and affecting the relative constituents of the fluids and the structure, to the effects of small doses in disease, than where the phenomena are merely functional. Chemistry also has not yet made such advances as to indicate pathological changes, and it is questionable whether chemical re-agents are calculated to detect the finer shades which are occasioned by homoeopathic action. Let us consider, in the first place, the obstacles opposed by the living and organic body to such inquiries; and secondly, the uncertainty whether the material changes effected by medicines in our doses, arsenic, for instance, acids, carbon, lime, present such chemical differences, and last so long, as to fall under the notice of the analytical chemists, as happens with regard to such allopathic remedies as act principally in a chemical way. On this subject the researches of Mitscherlich, Liebig, &c., have established certain data; from which we learn that chemical action may happen in the following modes: (1) upon the external skin, deoxidizing, abstracting water, or combining with its constituents (albumen compounds) or producing coagulation; (2) on the intestinal canal, in similar ways; (3) by affecting the solubility of ingesta in the intestinal canal; (4) on the mucous membrane of the air-passages (in the form of gas); (5) on the blood, through the respiration, or absorption from the mucous membranes or skin; (6) on the internal tissues and constituents, through the mediation of the blood, or by infiltration of the tissues. Either the constituents are dissolved by chemical agents (alkalis, iodine, acids, water,) brought into the circulation and excreted, or insoluble compounds are formed, especially with albumen (compare Mitscherlich's researches on the Sulphates of Copper and Iron, in Muller's Archiv. 1838, s. 1; on the Relation of Acetate of Lead to Albumen, Casein, Osmazome, Gelatine, Mucus, Fibrine, to o 2 196 APPENDIX. Blood, Urine, &c.; in the same Journal, 1836). The chemical actions on the blood appear to be the following: formation of blood (tonics, nutrients, iron); diminution of formation (lead, quicksilver, salts, alkalis, antiphlogistics); increase of particular constituents in it (carbon, oxygen, salts); acceleration of metamorphosis by an increased addition of oxygen (nitric acid, the water-cure?); retardation of its natural changes (inadequate supply of oxygen, abstraction of water); increase of its coagulability, plasticity; diminution of its coagulability (by salpetre, alcohol, salts especially prussic acid); and the introduction of peculiar changes proper to the science of sanguification. Although these rude chemical changes and actions cannot be cited in homceopathic therapeutics (they need confirmation, and their use is too much founded on dogmatism to be yet applied to the treatment of disease), yet do the results of several medicines (we recollect the acids, Arsenic, China, Phosphorus, Calcarea, chloride of Sodium, Baryta, Silica, Graphite, Carbon, Sulphur,) point to many of the above mentioned modes of action, which are necessarily connected with material changes in the blood. Let us consider that Copper, Zinc, Lead, Arsenic, Manganese, &c., have been lately discovered in the blood; whether they are accidental or necessary constituents of the blood we do not yet know. Phosphorus, Sulphur, and Iron are, however, essential constituents. Their influence is the more remarkable from the smallness of the quantities in which they are present. The same is the case with the above mentioned metals. Now, why should not a small quantity of a medicine excite as essential changes in the blood pathologically as these do physiologically? The influence of acids (Carbonic acid in the blood), salts, and earths, on the formation and metamorphosis of the tissues, is known. We find carbonates and phosphates of Lime in the bones, in all the fluids, and in each cell-formation; phosphates and carbonates of Mlagnesia in the bones, Natrum muriaticum in all the fluids and tissues, carbonate of Soda in the blood and in the lymph, Silica in the urine, saliva, hair, bones; and these are pre APPENDIX. 197 cisely the substances which the most remarkably develope the vegetatiye actions of medicines in homoeopathic pharmacology. Let us consider further that Oxygen, Carbon, Hydrogen, Nitrogen, Sulphur, Phosphorus, Chlorine, Calcium, Fluorine, Kali, Natrum, Silicium, Magnesium, and Iron, are the principal constituents of which the essential organic substances are composed; that out of the different atomic relations of these elements, with trifling discrepance, a new radical (hypothetical, it is true, and not capable of being presented in an isolated condition) Protein is formed, which again, in combination with other substances, with slight variations, presents the manifold modifications of the organic substance (albumen, fibrine, caseine, globuline), so that these form a series of protein compounds with Phosphorus and Sulphur, and their different combinations with water, salts, &c.; that by a slight change in the dextrine (starch gum) of the vegetable matter of the ingesta, possibly the analogous gelatine is formed, as from the vegetable albumen the protein; that, finally, in the normal functions by respiration (combination of the carbon of the ingesta with the oxygen of the air), by exfoliation from free surfaces, by the skin, the liver, the kidnies, a continual decomposition of protein takes place. Under these circumstances of constant and easily effected organic change, it is not too bold to attribute to medicinal substances a chemical action, not to be measured by the standard of inorganic chemistry, or of our present analysis. We allude particularly in this last respect to Bocker's researches with regard to the reproduction.* The urinary excretions, the proportion of carbonic acid in the respiration, the elementary and form-changes of the blood, during the use of various medicines, are here observed. The results of the action of Belladonna, Sulphur, Kali aceticum, here given, confirm the other known effects of q: Beitrige zur Heilkunde, insbesondere zur Krankheits,-Genuss-mittelund Arzneiwirkungslehre, nach eigenen untersuchungen, B. i. and ii., Crefeld, Juncke u. Mueller. APPENDIX. 199 (3.) Whether the interval between the dynamic and material action be not so small as to allow us to adopt the idea of their being simultaneous. The solution of this question is interesting in a scientific point of view, but it only receives a practical importance when we consider it from a somewhat comprehensive physiological point of view, and refer the dynamic to the activity of the nervous system, against which we set that of the blood and different organs; in other words, when we put the question (4.) Whether medicines act through the blood or the nerves? And here the following possibilities occur. (1.) Medicinal influences may act only'through the nerves; (2.) Only through the blood; (3.) Or they work through both, and (a.) The nerves give the first resistance, or (b.) The blood. Cases 1 and 2 contradict, by their isolation of vital phenomena, daily experience and the laws of life, which present the antagonism between force and matter as the indifferentiation of the different, as Schelling would say, and deny so exclusive an action of either of the systems. Case 3 is the only one, therefore, to be considered; and indeed it is probable that (a.) In the great majority of cases the action proceeds from the nerves, and in such a manner that (1) the nervous tissue is immediately affected, or that (2) the blood is the bearer or medium of the action, in such a way that medicines are brought into contact with their related nerves and organic systems by means of the blood, and that from these again a reaction on the blood and organs follows. These would be the so-called dynamic actions, in which a special physical electric influence enters,-a thing quite possible according to Dubois Raymond's experiments, or, as we have indicated above, only temporary, quickly passing, from their insignificance imperceptible, chemical metamorphoses. But there may also occur (b.) In the blood itself such primary material changes, as to alter the nerves in a more or less material way. Arnold 200 APPENDIX. has on these points given very valuable remarks, and interesting examples, and established facts. In the same way as the cellular tissue, the mucous and other membranes, and different tissues (according to Emmert's researches) may become infiltrated with medicinal substances, so may the nervous tissue likewise. We may give as examples:-the strong action of Belladonna on the iris by local application; the topical action of sedatives, as Opium, the application of medicines for the glands, which produce a quick local action without the participation of the organism; the narcotisation of isolated nerves by means of Opium and Nux vomica-tetanic fits in frogs, even when the heart has been separated by ligatures, or entirely detached, after the introduction of Strychnine into the skin, the cellular tissue or the stomach. The extension of medicinal action by means of the blood (2) (although the lymphatics as well are here active, yet absorption takes place in general by the veins) is rendered probable by the recovery of substances in the blood, in the secretions, in the substance of the organs, and in the expired air. The necessity of previous reception into the blood before general action can take place may, however, be admitted as a general rule. After the application of cupping glasses to a poisoned wound, or of a torniquet above the wound, no general action follows, although general action will follow if vascular communication with a poisoned and detached part be kept up artificially by a tube. Medicines introduced immediately into the blood act in general with greater speed and violence. Nervous communication merely will not ensure general action: on the contrary, division of the nerves, of a part, or of the spinal marrow, or in general interruption of the nervous communication, will not prevent it, as Arnold's experiments with Strychnine fully prove. In fine, there is no doubt, as we have shewn above, that medicines cause material changes in the blood itself, from which the nerves are affected secondarily (b). In addition to the examples given above we may here cite, that Saltpetre and Sal ammoniac lessen the coagulability of the blood. The passage of Phosphorus into the APPENDIX. 201 blood shews itself externally by the smell of the expired air, and its emitting light, by a diminution in the circumference of the blood globules, and in the coagulability of the blood, and from immediate contact by softening of the spinal marrow.* Acids and bases evince their affinity also in the organism. The vegetable acids change themselves into carbonic acid. Iron, Saltpetre, Sal ammoniac, Phosphorus, enter into combination with the constituents of the blood; Saltpetre, Sal ammoniac, common salt with the protein. All this authorizes us to characterize the separation and apposition of the dynamic and the material as a misapprehension of the vital manifestations. We are also compelled to ascribe an important part in the giving effect to medicinal action to the vascular as well as to the nervous systems. An examination, however, of homneopathic specific action, the quality of the medicines employed, and the manner of cure, its frequent lightning rapidity, all induce us to ascribe in by far the great majority of cases under our mode of treatment the decisive influence and the primary action to the nervous system. The consideration of the morbid process. After the observation of the locality as regards the functional and material phenomena of the morbid state, comes the consideration of the morbid process itself. The specific relation of the medicine to this element must necessarily play an essential part in the similarity, the agreement between the medicine and the disease. For it is undeniable that the individual nature of the disease which must correspond with the individual character of the medicine, is principally based on its peculiar life, which takes a certain physico-pathological course on a given anatomical basis, and perfects its development according to certain laws and tendencies. An ulcerative, croupy, catarrhal, and typhoid process, occurring as they do on the same mucous membrane, will depend on the most different pathological conditions, & See Arnold's Researches, Hys. Bd. xxiii, S. 9 ff. 202 APPENDIX. diverging in determinate pathogical directions materially and functionally. It becomes, therefore, the problem of a rational pathology to discover those several physiological fundamental conditions, simultaneously with the anatomical seat in each case of disease. But it is also necessarily the problem of rational therapeutics, (a problem to which the therapeutico-physiological school, consequently the homoeopathic, can alone claim the praise of having attended,) to determine the physiological fundamental character which must qualify the medicine employed, if it is to act on this peculiar process. Now it is the provings of the medicine on the healthy body which afford the means of attaining this knowledge. We willingly confess, however, that we need the aid of pathological experiences to facilitate the generalization of the morbid process which we require: in one word, that the symptoms alone, without further combination, comparison, and induction, will never lead us to sound conclusions on the morbid process. For instance, it is of great importance to us, and it facilitates the indication when we know the particular pathological state which underlies a diarrhoea, and consequently led by the symptomatology and practical experience, distinguish the relation of Mercury to the hyperaemic, of Pulsatilla to the gastric-catarrhal, of Antimony to the gastric, of Arsencium, of Acidum phosphoricum, to the typhous, of corrosive sublimate to the dysenteric process. At another time the conditions underlying the diarrhoea, such as teething affections, tubercular disease, scrophula or pregnancy, require a special consideration, which must not be confined to the symptoms of the medicine merely, but must also be directed to the generalization that a given series of medicines exactly corresponds to this or that process, and to that series must our attention be limited, and out of that series must corresponding symptoms be selected. In tubercular diarrhoea we therefore make our selection, similarity of symptoms being presupposed among Calcar., Chin., Ferr., Phosph., Arsen., and in scrophulous, among APPENDIX. 203 Calcar., Lycopod., Silic., Baryta, &c.; when occurring in pregnancy, iamong Antim., Lycopod., Phosph., Petrol., Sep., Sulph.; in teething, among Chamom., Merc., Calc., Ipecac., Sulph. and Phosph., &c. Without this knowledge of the special relation to the morbid process, acquired from the general physiological and special pathological character of the medicine, we may be often led astray, though an apparently exact correspondence of symptoms may exist, for this may be merely superficial. We proceed to give some examples by way of illustration. The treatment of ulceration of the mucous membrane of the mouth will be very different according as it is dependant on simple hyperaemia or local causes, (ulcers of the follicles, phagedenic, excavating ulcers,) scurvy, mercury, syphilis, or other constitutional causes. In such cases the symptoms corresponding to the form of the ulcer are less decisive than the character of the medicine. Vomiting, constipation, are frequently almost isolated symptoms of disease. If we now compare the exciting causes which underlie those in strictness only symptomatic but not the less substantially occurring states, and consider how on the one side in practice such states occur as partial diseases, presenting only a few points of observation, and how on the other hand the medicinal symptoms exactly on such points present indications but little characteristic, it becomes clear that it is only the relation of the medicine to the different pathological processes which call forth one and the same symptom which can produce a rational cure. The use of Iodine, of Bromine, of Spongia in croup is well known. On comparing the symptoms they excite with those of croup, a great similarity is perceptible. But who will deny that many other medicines present quite similar if not quite such characteristic symptoms, without having their specific relation to this process confirmed by experience, as for instance Conium, Ipecac., Sepia? In spite of the well defined symptoms which distinguish the medicines against toothache from one another, we have often transitions from one to another, as for instance between Mercurius and Chamomilla, Nux and Sulphur. If then the 204 APPENDIX. symptoms are not sufficiently marked to determine by themselves the choice of the medicine, the congestive, the nervous, the arthritic, rheumatic, carious character of the toothache, and the correspondent peculiarity of the medicine comes in to our help. A typhous, tubercular pneumonia will call for other medicines than a pure one, even though the symptoms may appear alike. Dropsy after exanthemata requires in consequence of the underlying diathesis other medicines (Ars., Dig., Hell., Calc., &c.) than one after debilitating losses of the fluids (China, Ferr., Sulph., &c.); or in consequence of organic degenerations (Kal., Lye., Baryt., Spig., Squill, &c.). Quite in this connexion occurs the necessity to pay attention to the stage of the morbid process, for this is always changing and puts on different characters at its different periods, consequently requires different medicines, as for instance is particularly remarkable in inflammation. On perceiving the external manifestation of these changes, the practitioner will derive great advantage in selecting medicines which in their general and special physio-pathological character correspond to this or that period. Thus we employ Bryony in consequence of its tendency to produce exudation in the second stage of inflammation, but Aconite in the first. Thus does the action of Phosphorus on the nerves of the vessels explain its employment in the stage of hepatization of the lungs, that of mercury its use in the suppurative stage of inflammations, that of Hepar Sulphuris in abscesses, the second stage of catarrh, the third of hooping cough, the commencement of the retrogression of croup. Thus the different periods of hydrocephalus, the progressive degrees of scrophula, of syphilis according to the affected tissues, (primary, secondary, tertiary symptoms,) make differences in treatment. All demands a symptomatic phenomenal basis, and yet requires a deeper physiological appreciation. Here we have a confirmation that we should never, for the sake of the symptoms, which however are our guideposts, lose sight of the generalization; that this latter, however, is never for us a vague and hypothetic essence, but APPENDIX. 205 must depend upon objective perception. In the particular we never lose sight of the general, nor in the latter the former. The consideration of the external and internal exciting causes. Since disease is a process compounded of the outward noxious influence and the activity of the organism, upon which the former must be considered as still exercising a continued influence, we cannot thoroughly characterize the disease without knowing its external exciting cause; not merely in the internal physiological causal element, which we, who have no great love for speculations about the "essence," suffer to stand over with the proximate cause. With regard to the choice of the medicine also we have to prosecute our enquiries on this side. Medicines, we have seen, are distinguished in relation to different processes and forms of disease, it is therefore evident that in the question of similarity not only have we to do with the symptoms of the disease at present under our notice, the so-called "status proesens," but also with the past, the preceding symptoms, the course from the first development, together with the predominant exciting elements. For a gastric disturbance, a chill, an overheating, an emotion, a weakening influence from loss of fluids, though they may call up a similar form of disease, for instance, a cardialgia, must yet be met by very different medicines. If this be important in acute diseases, it is much more so in chronic, where the so-called constitutional disturbances, generally depravation of the whole mass of the circulating fluids, render an exact appreciation of the exciting causes necessary for their successful eradication; for there is not in the symptoms alone without this point of support, without a previous resolution of the question whether in reality such a general disease underlies the phenomena, a sufficient indication for the cure. Hahnemann, therefore, in spite of all his dislike for subjective reflexion, in spite of his dictum to keep to the objectively perceptible symptoms, created the psora-theory, which, if we give up the indefensible categories, rightly viewed, was 206 APPENDIX. nothing more than a recommendation to enquire into the deep seated etiological relations, an enquiry extending necessarily into the remote past. Closely connected with these causal relations is the strictest consideration of the individuality in all its relations. This element is a not less important requirement for a just appreciation of the relations of the medicine to the disease. In going with precision into the causal elements, we come to the circumstances which occasion certain predispositions to disease, which assist in the determination of the character of the reactivity, the so-called strength of the individual. These are birth, education, habits, mode of life, in a word, congenital and acquired dispositions. These explain the prevailing tendency to this or that disease; for example, to catarrh, rheumatism, congestions; the predominance of the venous system, lymphatic obstructions, scrophula; finally, also the sthenic, erethistic, or torpid character of diseases, which are founded more in the general relation of the individual, in his reactivity particularly, in the elements belonging to the past, than in the local constitution, or the special physiological nature of the disease. Thus a strict examination into all the predominant internal and external exciting causes leads us into the characterization of the individuality, which is therapeutically indispensable to us, because it facilitates the diagnosis of the disease in many regards, and not unfrequently determines the choice of the medicine; for as we have seen, it is not only of advantage to us to know whether we have, for example, to do with a congestive or a dyscrasic inflammation; whether a node owes its origin to gout, or to the abuse of Mercury, or to scrophula; whether hypertrophy of the spleen is occasioned by abuse of China, or by internal causes; but it is also of great importance for the choice of the medicine whether a haemorrhage bears a sthenic or asthenic character; whether a spinal irritation is a sympathetic or primary affection of the spinal chord without previous sexual weakening, or whether it is the consequence of over excitement in connection with loss of fluids. APPENDIX. 209 in large tableaux, like types of disease! However much there may be mysterious about the external physicotelluric states, about their share in the miasmatic or contagious nature of diseases, and about the essential nature of epidemics themselves, experience undeniably shows that each disease that appears in an epidemic form preserves its own special peculiarity. It is possible and probable that this speciality of particular epidemics depends on those unknown cosmic conditions; for otherwise a fact known to every practical homoeopath would be inexplicable, viz., that medicines even quite suitable will be vainly employed in epidemics until experience after a careful comparison of the specifically indicated medicines discovers the one exactly corresponding with the prevailing epidemic conditions. We have only to think of the influenza, autumnal dysenteries, epidemic diarrhoeas, typhus, and cholera epidemics. The different remedies found especially efficacious in one epidemic show themselves perfectly inoperative in another. A more precise appreciation of the elements underlying epidemics must be arrived at, if we are to get a process of cure rationally adapted for all cases. The idea of specificity, and homoeopathy as its doctrine. If we now reconsider the elements developed in this division, it will become evident, that under all circumstances the objectively present phenomena, the symptoms, deserve the first consideration in the relation of similarity, because they give the most remarkable fixed points for the choice; that this consideration, however, is not the only one, but must be completed by the establishment of a correspondence as to all the relations already described. With the purpose of expressing more clearly this exact definition, not as some think, extension of the homoeopathic principle, homoeopathy has itself been indicated by several of its cleverest cultivators as the doctrine of specificity, or the specific method of cure. It remains a question whether this was necessary, still more whether it was advantageous. It did not diminish misunderstandings; on the contrary. In various quarters this was P 210 APPENDIX. treated as a surrender of the distinguishing principle, as a return to old medicine. This, however, is by no means the case, when the difference between the modes in which the idea of the " specific" is understood in the two schools is considered. The old school has its " specifica organorum, et morborum." As to the first, it forgets the difference of phenomena, and with regard to the last restricts itself to names and classes of disease, as Celsus, Dioscorides, the Galenists, Dr. Hoffmann, and Hufeland prove, and more lately Oesterlen, Ruete, &c. And even Kopp, who in a modified way defends homoeopathy in his "Deukwurdigkeiten" has only " specifica organorum." Others, as Sachs and Stieglitz, lay the chief stress on the certainty of action on a given organ, and do not shrink from taking into the definition the acknowledgment of ignorance as to how this action takes place. Wendt and Griesinger consider " arcana" and "specifica" identical. Wunderlich, who often uses "cempirical" and " specific " as synonyms, confesses likewise the obscurity in which the mode of action is involved, and has principally "specifica morborum" in the usual way. H. L. Richter's statement characterizing in one sentence the whole modern tendency of the new school is an accurate description of this mode of view. " The special indications of diseased forms (indicationes morbi) are not so much directed to a specific medicine, or a specific method, (which with the advance of science, will gradually give way to indications of cure based in physiology,) but result from special peculiarities of individual diseased forms or species, principally (sic!) from particular stages of the morbid process, &c." * Walther comes very near to the true idea of the specific t when he supposes that each medicine may act specifically, and that this specificity consists in a condition to be exactly determined essentially from the morbid life, which must be investigated in the disease as well as in the medicine. These conditions are general and particular, and affect the individual constitutions of the human organism ~ V. gt. Grundriss d. inn. Kl. 2 Aufl., 1853, S. 13. t Hufeland's Journal, May, 1839. APPENDIX. 211 and their variations, including all and every alteration of the variations of the morbid character occasioned by the external universe. Each alternation which the diseased forms pass through in different phases of their development, determines the specificity of individual medicines, consequently the specificity is of an alternating character, &c. He wants however the knowledge 'that the medicine itself is a pathogenetic element, and has of course no idea of the mode in which this is to be established. The new school has specifics against morbid processes, as Tart. em. against pneumonic, or chemical states, as Beneke and Garms teach. But both these cases are partial, and the last, in consequence of the progressive nature of chemistry, passes on into hypothesis. We were much surprised to find even Kissel stating that the idea of the specific was capable of being investigated in a chemical way. Medicinal substances, according to him, supply a specific want in the blood or organs, which occasions disease. If they remove this want, the basis of the disease, and the process dependent on it, they become specific medicines. This is not acting on the form, the function, and the process, but upon the basis, the cause, and the essence, which excited the pathic process in the blood or the organ. And because homoeopaths do not proceed upon the essence (this essence) of the disease, but in the most recent development of their doctrine, hold no longer "indeed merely to the external symptoms, but only to the appreciable anatomico-chemical changes, which do not allow us to ascertain the essence, and do not vary with it," consequently "they do not possess the correct idea of the direct mode of cure, which is also sometimes called the 'specific.'" We see, on the contrary, on how much surer a basis this idea of the specific is built in the homceopathic school. Hahnemann takes as the specific "not the general in medicine, but something quite special." Everything with him is "individual and special." There are with him no C absolute specifics " for particular diseases in the usual sense, but there are as many specifics as there are different states of individual diseases. The "similia " must con 212 APPENDIX. sequenly correspond not to genus and species, but to particular cases in all their peculiarities. Provings on healthy persons are the sure guide to the knowledge of the tendencies of medicinal action, and to their employment on fixed principles. Homoeopathy is consequently the doctrine of rational-specific medicines. Stapf* calls specificity the condition of mutual relationship of different influences as well as of diseases, and the influences which affect them (external circumstances) in the last case, " a natural relation," which depends on mutual, most intimate, and essential peculiarities. "Wolft extends the idea of specificity to diseases in specie, but is not fond of this expression on account of its abuse in the old school. Roth and Kurtz particularly, limit the idea more strictly. It is not enough to know the affected part, but we must enquire into the primary and chiefly affected factor, into the organic tissues, &c., so as to learn what organic functions suffer, and in what peculiarities the pathological state consists. For all this we must find a correspondence in the medicine. This is Schroen's " concrete-specific" method, and Martin's fundamental state of the disease, which requires the corresponding similar medicine. J. W. Arnold, who had some time before expressed himself on the "individual" in the specific, has very well arranged the particular requisites for the same. According to him the principal part of our knowledge of the specific peculiarity of the medicine we are about to use homoeopathically consists in the knowledge of its elective action on an organ or system, and in an exact characterization of the kind of affection excited, obtained by an observation of the functional powers, which are to be submitted to a physiological analysis, in order to obtain the internal connection of the disturbance, as well as of the physico-chemical changes. The idea of specificity, however, comprehends in itself the special and proximate relations to the peculiarity of the disSArch., i, 1. f Idem. 418. SELECT HOM(EOPATHIC BOOKS, Published or Sold by HENRY TURNER, 41, PICCADILLY, MANCHESTER. THE BRITISH JOURNAL OF HOM(EOPATHY, EDITED BY Dns. DRYSDALE & DUDGEON. Published Quarterly, Price 5s. The above is the oldest Medical Quarterly Journal in Great Britain. BRYANT'S (DR. J.) POCKET MANUAL, OR REPERTORY OF HOM1EOPATHIC MEDICINE. 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