HOM(EOPATHY IN VENEREAL DISEASES. BY STEPHEN YELDHAM, M.R.C.S., SURGEON TO THE LONDON HOM(EOPATHIC HOSPITAL; FELLOW AND VICE-PRESIDENT OF THE BRITISH HOM(EOPATH1C SOCIETY; ETC. (33 SECOND THOUSAND. LONDON: H. TURNER AND CO., 77, FLEET STREET, E.C., AND 106, NEW BOND STREET, W.; MANCHESTER: 41, PICCADILLY, AND 15, MARKET STREET. 1864. Just Published, price 2s. 6d., Secrnd Edition, HOM(EOPATHY IN VENEREAL DISEASES. SBY S. YELDHAM, M.R.C.S., SURGEON TO THE LONDON HOM(EOPATHIC HOSPITAL. OPINIONS OF THE PRESS. "The present work is unmistakably the production of a practical man. It is short and pithy, and contains a vast deal of sound practical instruction. The diseases are briefly described; the directions for treatment are succinct and summary. It is a book which might with profit be consulted by all young and many old practitioners of Homceopathy."-British Journal of Homoeopathy. " We have no hesitation in recommending it to the favorable notice of our readers."-Hommeopathic Observer. " This excellent brochure will materially assist in filling up a void in our Homoeopathic Literature for well-written essays on special diseases."-zlAmerican Homoopathic Review. PREFACE. THE author does not profess to give, in this small volume, an account of all the ailments incidental to Venery. Such an undertaking would have carried him far beyond the object he had in view, which was, to place before his professional brethren the conclusions he has arrived at, from his own experience, in the homoeopathic treatment of the common Venereal diseases. English homoeopathic literature is almost silent on these diseases. Following, in his earlier practice of homoeopathy, the few scanty directions contained in " Jahr,' the author found that the results were not so superior to those of allopathy, as he had expected. Some modifications in the treatment were, evidently, "necessary. Careful observation convinced him that CONTENTS. PAGE VENEREAL DISEASES, introductory remarks on.. 1 Balanitis...... 2,, treatment of.... 4 Gonorrhea.... 6,, treatment of.... 9 Gleet...... 19,, treatment of..... 20 Bladder, irritation of.... 23,,, treatment of... 24 Erysipelas of the penis.... 25 Chordee...... 26 Testicle, inflammation of.... 26 S 1.. treatment of... 27 Prostate gland, inflammation, and treatment of.. 30 Stricture..... 33,, treatment of.... 34 Gonorrhoea in women.... 37,,,, treatment of... 38 Cases of the foregoing diseases... 40 PRIMARY SYPHILIS..... 53 Chancre, soft..... 55,, hard..... 56 b .VI CONTENTS. PAGE Chancre, phagedenic... 57,, urethral.... 59 Primary syphilis, treatment of.... 60 Bubo, and treatment of.... 71 SECONDARY SYPHILIS.... 74 S of the skin, viz., exanthem.. 80 papules.. 81 pustules.. 81 ulcers.. 82 tubercles.. 82 Secondary affections of mucous membranes.. 82 Treatment of secondary syphilis... 84 ~, diseases of the mucous membranes. 89 TERTIARY SYPHILIS..... 92,,,, of the bones.... 92 Gummata...... 93 Syphilitic sarcocele.... 94 Syphilitic cachexia..... 95 Treatment of tertiary syphilis.... 95 Cases of the foregoing syphilitic diseases.. 100 HOM(EOPATHY IN VENEREAL DISEASES. VENEREAL DISEASES. THE general term "venereal diseases" includes two entirely different disorders-the one called chancre, syphilis, the pox; the other gonorrhoea, or, vulgarly, the clap. These were formerly regarded as modifications'of the same disease. Later observation has, however, clearly established the fact that the two complaints have their origin in two different poisons. They give rise to different symptoms, lead to different results, and demand different kinds of treatment. The two diseases often coexist. They may be contracted at the same time, or the one may be superadded to the other. This should not be lost sight of in examining a patient affected with a venereal disease. I have more than once known a discharge from a chancre, situated under a contracted foreskin, mistaken for gonorrhcea; and it is equally possible for the discharge from gonorrhcea to obscure a chancre. Hence it is indis1 BALANITIS. the glans penis become red, with bub slight discharge; in others, the whole of this part of the membrane, as well as that lining the prepuce, will be found of the deepest red, swollen, and velvety, thrown into rugTa, and discharging large quantities of pus. In these latter cases the glands in the groin may become sympathetically affected, but they seldom or never suppurate. It is important to distinguish this disease from syphilis on the one hand, and gonorrhoea on the other. It is only where phimosis, congenital or acquired, exists, by which the secretions are retained under the foreskin, that there is any chance of its being mistaken for gonorrhoea. In this case the diagnosis may be decided by noticing the source of the discharge. To effect this, the cavity of the prepuce should first of all be well washed out with warm water, thrown up by a syringe. Then, retracting the foreskin so as to bring the orifice of the urethra into view, it will at once be seen whether any matter escape from it: if so, the irritation is distinctly urethral; if preputeal, there will be no discharge for some time after the part has been cleansed. Again, it is not always easy, at first sight, to distinguish the ulceration which sometimes attends balanitis, from that which ushers in an attack of syphilis. It is no uncommon thing for the first outbreak of chancre to be accompanied by a considerable amount of irritation of the parts, and the appearance of several small superficial ulcerations, and it is only after this irritation has subsided, that the real nature of the disease is declared, in the per BALANITIS. 5 opposed surfaces of the inflamed membrane asunder. It is well, also, to administer a dose of Aconite at bed-time, and a pilule of the third decimal potency of 1fercurius corrosivis or solubilis once or twice a day; and strict abstinence from stimulating drink and food should be enjoined. When phimosis accompanies balanitis, it is difficult, or impossible, to retract the foreskin for the purpose of cleansing the parts and applying a lotion. In these cases the discharge should be washed away with a syringe and warm water, and immediately afterwards weak Calendula lotion should be thrown up in the same way. These means, combined with the administration of the medicines I have just named, have never failed, in my experience, to eradicate the disease. Should the phimosis be congenital, and the patient be annoyed with persistent discharge, the propriety of dividing, or circumcising, the foreskin, may be considered. Contemplated matrimony may render the operation desirable, but it is rarely, if ever, demanded by balanitis. The contraction which, temporarily, it may give rise to, subsides with the irritation. 6G GONORRTHIEA. By this term is meant inflammation of, and a discharge, from, the urethra. The discharge may arise from leucorrhoea in the female, or other exciting agents, but, as a rule, it is contracted in intercourse with a person similarly affected. Gonorrheea, like other diseases, varies infinitely in its, intensity and duration, in different subjects. One case, from first to last, will be so mild as scarcely to cause the patient any annoyance beyond the simple discharge; another will be attended with symptoms, both primary and sympathetic, of the most painful description; and between these extremes cases of every degree of severity occur. An average case of gonorrhoea presents four stages, viz.The first, or initiatory stage, which lasts from twentyfour hours to a couple of days, and consists in a slight tickling, or tingling, at the orifice of the urethra, and the flow of a small quantity of thin, transparent mucus, or milk-like discharge. Secondly, to this succeeds the inflammatory stage, in which the lips of the urethra become red and swollen, the discharge becomes copious, thick and milky, yellow, or greenish; the act of micturition is attended with pain GONORIUHfEA. 7 and scalding, whilst erections and chordee torment the patient at night. During this stage, also, the most distressing of the complications of the disease are apt to occur, such as irritation of the bladder, inflammation of the testicle, and of the prostate gland. The third stage, viz., that of subacute inflammation, follows the subsidence of the foregoing acute symptoms. It is marked by slight irritation in making water, and the continuance of a discharge of yellow matter. This stage is apt to be protracted, and to result in theFourth stage, or gleet, which consists in the recurrence, from time to time, of small quantities of discharge of a transparent, or, more commonly, of a milky secretion. This stage is usually unattended by any pain or irritation. But for the stain on the shirt, the patient would be unconscious of anything abnormal. The discharge at this period is said to lose its infectious property; but, as the precise juncture at which the change takes place is uncertain, no person, having a discharge on him, would be justified in indulging his sexual passion, and thereby subjecting another to the risk of contagion. The susceptibility to gonorrhcea varies greatly in different individuals, and under different circumstances. Some persons hardly ever indulge in impure connexion without contracting gonorrhoea; others, though not a whit more virtuous or careful, escape infection altogether. This greater liability to the disease in some persons than in others, is doubtless mainly due to different degrees of natural sensitiveness in the mucous membrane lining the S GONORRHCEA. urethra. There is, also, an acquired insusceptibility to gonorrhcea. Repeated attacks render the mucous membrane of the urethra comparatively insensible to the gonorrhoeal virus. The first attack is generally by far the most severe; whilst subsequent attacks are often attended with but little suffering or inconvenience. Prognosis.-There are no points in the history of gonorrhoea on which it is more difficult to pronounce an opinion than the probable course, duration, and result of an attack of gonorrhoea. From some unforeseen cause or other, the most carefully-weighed prognosis will often be falsified. One case will get well in a few days; another, in spite of the most careful treatment, will assume the most aggravated character, develope all the complications of the disease, and hang about for months. A case of this description has recently been under my care. The patient was of a fair, phlegmatic temperament. The attack continued in a mild form for some time; suddenly, inflammation of the prostate supervened; then the bladder became affected; to this inflammation of the testicle succeeded; and lastly, distressing irritation of the lower bowel. I have witnessed many such cases. A scrofulous constitution, and an irritable nervous temperament, are the chief predisposing causes of these aggravated and obstinate attacks. It should, therefore, always be borne in mind, and the patient, if necessary, should be made acquainted with the fact, that however mildly an attack of gonorrhea may set in, however promisingly it may for a time progress, GONORRH'EA.9 9 it is a disease liable, at any moment, to serious complications, which, in the most skilful hands and under the best system of medicine, may protract the treatment to an almost indefinite period. Treatment.-We have now to consider the most important point in the history of gonorrhcea, viz., its treatment. It is here that the old and the new systems come into comparison. It is an interesting fact, that the practitioners of the old system have arrived nearer to the truth in the treatment of venereal than of any other class of diseases. All their principal remedies in those disorders are specifics; in other words, homoeopathic remedies. Thus, mercury is the universally admitted specific for syphilis: it is used by the practitioners of both schools; and so also, copaiba, cubebs, and turpentine, are true specifics for gonorrhoea. The great difference consists in this: that the old school, whilst they cure their patients, poison them with enormous and disgusting doses of the remedies; the homoeopath, on the contrary, whilst he equally cures his patient, saves him from the painful penalties of the remedy, and, in addition to this, as we shall presently see, he possesses other and better remedies, of which the allopath is ignorant, or of which, at all events, he makes no use. Herein consists our great superiority. I do not wish to rob my allopathic brethren of one iota of credit which is their due, nor to claim for homccopathy any superiority to which it is not fairly entitled. I am ready to admit that, if a patient can make up his mind to GONORRHtEA. 13 allopathic surgeon. To do any good, it must be given in palpable doses. I am in the habit of prescribing from five to ten, or even fifteen drops of the mother tincture three or four times a day. In my own practice, the dilutions have proved nearly, if not quite, inert. Copaiba is a powerful homoeopathic remedy in gonorrhbea; but, unfortunately, whilst, like Cannabis, it requires to be administered freely, unlike that medicine, it is so objectionable in taste and smell, and in its effects upon the stomach, as to be often more intolerable to the patient than the disease it is given to cure. To obviate this difficulty, capsules of various kinds have been invented, and, as they answer the purpose of hiding the taste and odour of the drug, they present the best form in which it can be exhibited, when that medicine is deemed necessary. Copaibca is directed in some homoeopathic books to be given in the ordinary homceopathic dose. A careful watching of its effects in many cases, where so administered, has satisfied me that in infinitesimal doses it is perfectly useless. This opinion is supported by some interesting experiments made by Ricord, which go to prove that Copaiba acts, not dynamically, as most of our medicines are supposed to do, but by mixing with the urine, and so coming directly in contact with the diseased membrane. Ricord says:" We have had occasion to treat gonorrhoea in patients who suffer under urethral fistula at two inches, or two and a half inches from the meatus. In one of these cases blennorrhagia occurred in the vesical portion of the canal, GONORRHMEA. 15 homoiopathic medicines-Cannabis, for example-in the treatment of gonorrhcea. Thuja, is a remedy closely allied in its action to Cannabis, and may be prescribed in the same class of cases, and at the same stages of the disease, as that remedy. It is particularly indicated if, during or after the existence of discharge, warty growths present themselves on the corona glandi. or foreskin, or about the anus. The foregoing are the medicines on which, in the vast majority of cases, reliance may be placed in treating acute gonorrhcea. I have seldom found it necessary to travel beyond them. Yet, cases do sometimes happen in which, from the obstinacy of the disease, or from the prominence of some particular symptom, it is found requisite to employ other medicines. The chief of these are Sulphur, as an antipsoric in intractable cases, occurring in scrofulous constitutions; Capsicum, when the burning along the urethral canal is intense; Nux vomica, when the digestive functions are disturbed, and when the irritation extends to the rectum, causing frequent and distressing urging to stool, with the protrusion of piles. Two or three drops of the second or third decimal dilution of these medicines may be administered every six hours. Other medicines recommended are - Agnus castus, Argentumr nitricum, Cubeba, Petroselinum, Pulsatilla, Bhus Tox., Miezereum, Ferrum. I have occasionally employed some of these, but not with any very decided results. Injections.-Local applications in the form of injections, 16 GONORRHCEA. though repudiated by homceopathic authors generally, appear to me indispensable in the treatment of some cases of gonorrhea. The prejudice against them on the part of homceopathic practitioners is based, in the first place, on the groundless fear of causing stricture; and secondly, on the equally erroneous notion that they are antihomeopathic. The former of these objections I believe to be totally unsupported by facts. The common cause of stricture is that chronic irritation which follows an acute attack of gonorrhoea, in which the whole course of the urethra, from the orifice to the bladder, is implicated. The speedy cure of this irritation is the greatest safeguard against stricture; and it is beyond a question that injections, used with care and at the proper time, afford the readiest means of accomplishing that object. The second objection, viz., that injections are unhomceopathic is equally untenable. On the contrary, they appear to me to be truly homceopathic in their action. Gonorrhcea is inflammation of the urethra; injections should be weak and unirritating solutions of medicines, which in their concentrated form will, when locally applied, produce inflammation of the urethra! If this is not homceopathy, what is it? and even if it were not so, a case of gonorrhoea, in the speedy cure of which interests of the deepest import to the patient are often involved, is the last over which it would become the medical man to split straws on points of doctrine. The only question he has to consider is, by what means he can most speedily and safely cure his GONORRH(EA. 17 patient? The rejection of the valuable assistance which injections afford, places the homoeopathic practitioner at a great disadvantage in treating gonorrhoea. Injections, like all other remedies, to be efficacious, must be well timed and well chosen. As regards the former of these points, there are two periods in the course of an attack of gonorrhcea in which injections are admissible, viz., the earliest, or initiative stage, and the later, or subacute stage. The former of these extends over the first twenty-four or forty-eight hours, and comprises that period when there is simply slight itching, and perhaps some mucous discharge, and before the more acute and inflammatory symptoms have had time to develop themselves. At this juncture an injection of a mildly astringent character, used frequently, will sometimes succeed in arresting the further progress of the disease. I do not here recommend, or approve, the violent caustic lotions which the allopathic school employ under the unfortunately appropriate name of "the abortive plan;" neither do I think that, as a rule, injections should be used in the early stage of firsb claps, which are generally much more acute than subsequent attacks, and which, in spite of all that can be done to check them, will almost invariably pass through the regular stages of the disease. But, in those cases in which the symptoms are mild from the commencement, which manifest no disposition to become acute, whjch occur in phlegmatic constitutions, and in which the patients have been previously affected, injections may be 2 18 GON ORRHZEA. advantageously employed from an early period of the disease. Not only do they, under such circumstances, not aggravate the disease, but they contribute to a much more speedy cure than could be effected by medicines alone. The second period in which injections are admissible is that which succeeds to the inflammatory stage of acute attacks. It is here that injections find their most appropriate place. Great caution, however, should be observed not to inject too early. As a rule, the inflammatory symptoms should all have subsided. There should be no scalding or irritation of the bladder, and the discharge should have sensibly diminished. The disease should, in short, be decidedly on the wane. Injections should be resorted to only after medicines, steadily persevered in, have failed to cure the discharge. They are then both safe and necessary. Employed earlier, they may increase the existing irritation, and render the membrane insensible to their action when, at a later period, their employment might be indicated. As regards the composition of injections, this is a point which must be decided by the experience of the medical man. The medicines suitable for the purpose are various. I am myself in the habit of employing mainly the two following, viz., infusion of Hydrastis Canadensis, and the Liquor Pliumbi diacetas. Both of these are excellent remedies, and they appear to be very similar in their action. I use them almost indifferently, GLEET.. 19 substituting the one when the other fails. Properly diluted, they are unirritating, and simply soothing and curative in their effects. I generally order half a drachm of the Liq. Plumzbi to an ounce of distilled water, and the infusion of Hydrastis in the proportion of an ounce of the drug to a pint of water. I have frequently succeeded in curing, by means of one of these injections, or even by cold water only, discharges which had resisted the use of the strong injections ordinarily employed by allopathic surgeons. The mode of injecting is a point worthy of attention. The syringe should have a good long nozzle, which should be well inserted into the urethra. The injection should be retained for two or three minutes, by compressing the penis between the finger and thumb of the left hand, whilst the instrument is withdrawn with the right. It is well to try the effect of the injection every night in the first instance, and if it agree, repeating it more frequently afterwards, if necessary. During an acute attack of gonorrhoea, the patient should live on light and unstimulating food, and strictly abstain from all stimulating drinks, and, as far as practicable, avoid active exercise. Nothing favours recovery from an attack of this kind more than perfect quietude in the recumbent posture. GLEET.--Consists in the continuance, after all inflammatory symptoms of gonorrhoea have subsided, of a 20 GLEET. discharge from the urethra, of a fluid varying ih colour and consistency-being in one case simply mucous, in another, purulent..The quantity is generally small, often, not more than a few drops in the course of twenty-four hours; whilst at times it ceases entirely for days together, returning without assignable causes, or in consequence of some excitemient in the way of diet or exercise. Though most commonly the result of an acute attack of gonorrhoea, mild cases of that disease, also, not unfrequently run on, and assume the true characters of gleet. The sources of this discharge are various. In some cases it issues from the lacuna magna, situated a short distance up the urethra. When that is the case, a drop of the discharge may almost at any moment be obtained, -provided the patient has not recently passed water-by squeezing the end of the penis. In other cases it may proceed from chronic relaxation of the membrane higher up the passage towards the bladder, or from the prostate gland, or, more commonly still, from a stricture. This last point may be determined by exploration with a bougie. If no stricture exist, and the drop, as I have just described, cannot be squeezed from the orifice, and if injectipns used in the ordinary way fail to arrest the discharge, we may infer that the disease has its origin in some irritation or relaxation of the deeper-seated portions of the urethra. The treatment of gleet must be both general and local. GLEET. 21 The general treatment consists in the exhibition of such medicines as tend to allay irritation, and restore the tone of the urinary passages. Of these the most appropriate are the 'following: -Cantharis, iMercurius, Nux vomica, Pulsatilla, and Sulphur. A variety of other medicines have been recommended, but the foregoing are those from which experience has taught the homoeopathic surgeon to look for the most decided effects. The symptoms of gleet, irrespective of the discharge, are of so negative a character, that it is difficult to lay down any precise rules for the choice of any particular remedy. The selection must be determined as much by the constitutional as by the local symptoms. Gleet is very commonly found associated with a depressed state of the general health. In this case, Nzux vomica and Sulphur will be found of the utmost service. I have frequently witnessed the entire disappearance of the discharge, under the steady use of these two remedies, In cases where Mlfercury has been deemed necessary, I have found Cinna. haris the most useful preparation. Pulsatilla is a good remedy in chronic affections of the urinary organs, and is well suited to phlegmatic and scrofulous constitutions. PFerrumn in the form of Tinct. Ferri Sesquichlorid., in tendrop doses three.times a day, is at times efficacious, in gleet occurring in debilitated constitutions. Whatever the remedy, it should be persevered with steadily; and in all cases it is desirable to combine with medical treatment, the invigorating influence of change of air, to live temperately and nutritiously, and to practise local or general GLEET. bathing with tepid or cold water, according to the powers of the patient. Of all the stages of gonorrhoea, gleet is that which is most benefited by injections. Indeed, there are many cases in which all other means without this seem powerless. If the disease be confined to the lacuna magna, an injection used in the ordinary way will answer every purpose. If the discharge originate in irritation higher up the urethra, the injection should be applied by means of a catheter of sufficient length to reach the affected part. The distal end of the instrument should be pierced with a row of small holes, through which the injection, thrown up from an elastic syringe, may escape, and come in contact with the affected membrane. The disadvantage of this mode of injecting is this, that it cannot conveniently be accomplished by the patient himself, and necessitates daily attendance on a medical man. It is, therefore, better suited to hospitals than to private practice. "Chronic thickening of the lining membrane of the urethra, in some cases amounting to stricture, in others to mere irregularity of the canal, is a common source of gleet; and the restoration of the passage to its normal size, by the careful introduction of the bougie, is the proper mode of curing the discharge. When, therefore, after a fair trial, all efforts to arrest the discharge by medicines fail, a bougie should be introduced, and the passage explored. It may be that no well-defined stricture will be detected, but only a halting in the progress of the instrument, as if passing over some irregularities, COMPLICATIONS OF GONORRH(EA. 23 These cases, equally with completely formed stricture, yield to the use of the bougie. It is sufficient to repeat the operation every third day, or, in some cases, once a week, and the instrument should be allowed to remain not less than from a quarter to half an hour; a more frequent introduction is apt to set up violent irritation in the passage. Appropriate medicines, such as I have before indicated, should at the same time not be omitted. COMPLICATIONS OF GONORRIt (EA. By this term is meant, those affections which, forming no essential part of gonorrhoea, yet owe their origin to that disease, and require distinct treatment. The chief of these are, irritation and inflammation of the bladder, of the testicle, and of the prostate gland, phimosis, chordee, and erysipelas of the penis. IRRITATION OF THE BLADDER.-This is a common, and, at times, a very distressing accompaniment of gonorrhoea. Few acute cases are entirely free from it. It commonly comes on early in the disease, being coincidental with the most inflammatory stage of the attack. Its leading symptom is a painful, and, in some cases, an almost incessant urging to pass water; and the suffering 2. COMPLICATIONS OF GONORRH(IA. is often greatest the moment after the bladder has been emptied. The urine is generally loaded with mucus, and, in some cases, is intermixed with blood. In milder cases there is simply a slightly increased frequency in the desire to micturate, or, it may be, a suddenness only in the call, when it occurs at the regular intervals. In the severer cases the patient complains of a constant aching pain in the region of the bladder, and there is evidence of general constitutional disturbance, in accelerated pulse, loss of appetite, and sense of weakness. 'Trealment.-The remedy for the original disease will often be the most appropriate for this; yet, if the patient is not at the time taking Cantliaris, that medicine, in one-drop doses of the third tincture, in alternation, every four hours, with a like dose of Aconite, should be administered. These two remedies will seldom fail, in a few hours, to subdue the more violent symptoms, even if they do not entirely allay the irritation. When these fail, Belladonna may be had recourse to with great advantage. A drop of the second or third decimal dilution every two hours should be given. NiLx rom*ica, Puzlsatilla, and Slphur, are also useful remedies in obstinate cases. The,Spirit of Cuamphor, in six-drop doses, in water, repeated every two or three hours, will sometimes afford speedy relief from violent and spasmodic urging to make water. COMPLICATIONS OF GONOItRRH(EA. PIiuMosis.-This is not a frequent occurrence of gonorrhcea, and when it does occur, it is of slight inconvenience, being much less complete and obstinate than when it results from chancre. In some rare cases, however, the foreskin becomes thickened and constricted, difficult to be retracted, and the discharge may accumulate under it and irritate the glans penis. This occurs more frequently, however, in cases of congenital phimosis. In either case, the discharge should be washed away from under the prepuce two or three times a day, by means of a syringe and warm water, and the end of the penis may be enveloped in wet rag, and covered with oil-silk. The remedies which cure the gonorrhoea will,cure the phimosis also, if it be not congenital. ERYSIPELAS or THE PENIS.-Not uncommonly, during the earlier and severer stages of gonorrhea, the prepuce, and integuments of the body of the penis, are attacked with erysipelatous inflammation. The whole organ becomes red, inflamed, and swollen. The patient is often much alarmed at this condition; it is, however, attended with but little pain or inconvenience, beyond the bulkiness of the organ. It yields kindly enough to the exhibition of Belladomna and Apis-administered in drop doses of the second or third decimal dilution of the tincture, every four hours, omitting, in the mean time, any other medicine which the patient may be taking for the gonorrhca.. It is well here, also, to envelope the penis in wet cloths, under oil-silk. 26 COMPLICATIONS OF GONORRH(EA. CHORDEE, and other erections, which occur during the acute stage of gonorrhcea, though not otherwise important, often harass and distress the patient at night, and prevent sleep. When this is the case, his diet should be simple and spare, he should lie lightly covered; the penis should be wrapped in cloths soaked in cold water, to which a few drops of the mother tincture of Aconite may be added, and a drop of the third decimal tincture of the same medicine should be taken two or three times during the night, if required. INFLAMiMATION OF THE TESTICLE-OCHITIs.-This is one of the most severe and painful of the concomitants of gonorrhea, and may supervene either during the acute or chronic stage of that complaint. One of its earliest symptoms is, often, a hard, stunning headache. This will sometimes come on and last twentyfour hours before any signs of the local disease are manifest; and when, in the course of an attack of gonorrhcea, this symptom is complained of, the surgeon should be on the watch for that which is in all probability about to succeed-an attack of orchitis. This headache, however, is only occasional. The constant symptoms are, pain, swelling, and extreme tenderness of one of the testicles. The organ continues to swell during the first two days, and sometimes attains to the size of a small closed fist. There is generally redness of the scrotum, and often pain in the spermatic cord, extending COMPLICATIONS OF GONORIRHEA. 27 from the testicle up to the groin, and round the loin of the affected side, and the cord becomes much thickened. A case was admitted into the London Homceopathic Hospital last year, in which the swelling assumed many of the characters of scrotal hernia, and might have been mistaken for that disease, but for the fact that the man still had the remains of an attack of gonorrhoea. The pulse in these cases is small, quick, and jerking; there is shivering, thirst, and loss of appetite. The discharge from the urethra becomes greatly diminished, or ceases altogether, during the height of the attack. It commonly returns to some extent, as the inflammation of the testicle subsides. Treatment.-As regards the treatment of inflammation of the testis, there is nothing more surprising and satisfactory in the circle of medical practice, than the certain and powerful influence exercised over this complaint by homoeopathic remedies. It is difficult for the medical man, who understands the nature, intensity, and obstinacy of the disease, to credit the effects of these remedies, without witnessing them. They are the more striking when viewed in contrast with the treatment under the old regime. See a man in the latter situation. Here is the programme:-Purgatives to empty the bowels; tartar emetic to make him sick; the lancet, or leeches, to relieve him of his blood; calomel and opium to make his mouth sore; fomentations, astringent lotions! As I have said, -285 C031PLICATIONS OF GON0RRHOE A. the contrast between this and the effects of homoeopathic medicines, is something really wonderful. Aconite is the chief remedy. It should be commenced as soon as the first symptoms of the disease declare themselves, and be continued for twenty-four or thirtysix hours, in drop doses of the second or third dilution, every three or four hours. This medicine alone will, in many cases, effect a complete cure. It is well, however, after the constitutional and more urgent local symptoms have been subdued, to have recourse to Pulsatilla.-I prefer the second or third decimal dilution, and it should be repeated every three or four hours. It may be found necessary to administer an occasional dose of Aconite, whilst the patient is under the action of Pzlsatilla. These two remedies rarely fail to afford speedy relief. They should not be relinquished too hastily, if the amendment is not so rapid as the surgeon might at first expect. In the end, the cure will be effected earlier, than if he run impatiently from one remedy to another. During the height of the attack the patient should remain in the recumbent posture, and live on fever diet. When he gets up he should support the testicles in a suspensory-bag. The swelling of the gland, which remains as a temporary effect of the inflammation, will subside of itself in the course of a few days, or its reduction may be expedited by the exhibition of Mfercurius and Sultpkiur. I have rarely found it necessary to resort to any other than the first two remedies, viz., Aconite and Pudsatilla; 32 COMPLICATIONS OF GONOrRHA. again in the course of the night, if the patient is feverish and restless. I may here state that, instead of alternating medicines every dose, it is often preferable to give one kind during the day, and the other during the nightMedicines are less interrupted in their action, and each one has a better opportunity of producing its specific effect, when given in this way, than when changed more frequently. The more active symptoms being subdued by the foregoing medicines, Eali liydriodicwz comes in with excellent effect, in controlling the subacute and chronic stage of the disease, which is apt to succeed. It should not be given in too minute a dose. I have, myself, obtained the most marked results from one-grain doses of the salt every four or six hours. ThJina, Argentum, Aurwum, Calcarea, and a host of other remedies, are quoted as applicable to this complaint. They may occasionally be useful, but I am satisfied that we do better by adhering steadily to a few well-tried medicines. If suppuration take place, the matter may discharge itself either into the urethra or rectum; or the cellular tissue surrounding the gland may become implicated, and matter may form andpoint in the perinaum. In this case it must be evacuated with a lancet, as soon as fluctuation can be detected. 33 STRICTURE. By this term is meant a narrowing of some portion of the urethra, by which its capacity is lessened, and the flow of urine from the bladder impeded. The common cause of stricture is the inflammation attendant upon acute gonorrhoea, in which disease the whole length of the urethra is generally involved; and if the constitution of the patient be bad, and the recovery slow, chronic inflammation supervenes, and permanent thickening of the lining membrane is the result. The stricture may be situated in any part of the urethra, but its most common, seat is the membranous portion, just under the symphisis pubis. There may be one or several strictures, and the whole, or a portion, only, of the circumference of the canal may be implicated. In some cases a thin band only of the lining membrane will be stretched across the canal; in others, the strictured portion will occupy as much as half an inch of the length of the urethra. The symptoms vary in severity with the degree of stricture. The earliest symptom is ordinarily an increased frequency in the desire to empty the bladder, or the retention of a few drops of urine, which dribble away afterwards; and, on cooling, the urine deposits a cloud of mucus. The obstruction in voiding urine increases with the growth of the stricture, and the stream becomes smaller, 3 34 STRICTURE. twisted, and split. In almost every recent case there is, also, a gleety discharge. Indeed, the obstinate persistence of this discharge, is one of the most unfailing signs of the existence of stricture. In aggravated, and long-standing, and neglected cases of this complaint, the patient's sufferings are sometimes truly distressing. The irritation extends to the other urinary organs-the bladder becomes disorganized by the action of offensive ammoniacal urine, from the irritating presence of which it is never free, and ultimately the kidneys become involved in the destructive process. The patient is constantly impelled to fruitless efforts to empty the bladder, his rest is thereby broken, his appetite fails, his general health becomes broken, and unless timely relief is afforded, hectic succeeds, and he sinks under an accumulation of evils. A case of this nature, though, happily, fortunate in its termination, will be found amongst the cases at the end of this section. What is called spasmodic stricture seems to be simply an aggravation of an already existing stricture, by some exciting cause, such as sudden cold, over-indulgence in alcoholic drinks, and the like. Treatment.-The indications are to reduce any existing inflammation, and to restore the passage to its normal size. In some recent cases, in which the obstruction to the flow of urine depends on simple tumefaction of the membrane, medicines alone will suffice to remedy the evil, or GONORITHCEA IN WOMEN. 37 Aconite and Cantharis when there is much irritation of the bladder, or tenderness in the seat of stricture; Mercuris when there is purulent discharge; Nux vomnica and Sulpihur in the more chronic form of the disease, when there is derangement of the digestive functions, and in weakened and scrofulous constitutions. The following medicines, may, also, under particular circumstances be employed with advantage, viz., Clemnatis, Ocinabis, Silicea, Pulsatilla, Thuja. GONORRHCEA IN WOMEN. The remarks that have been made on the subject of gonorrhea in males, apply equally to women; but few additional words, therefore, are required here. The differences in the disease as it affects the two parties, respectively, are due to the different conformation of their genital organs. In women it is a much milder and more manageable disorder than in men. The female escapes much of the suffering, and most of the complications, that render the disease at times so painful and protracted in men. Indeed, so slight in many cases is the inconvenience which women undergo, that they are, from first to last, happily, ignorant of its nature, and attribute the discharge to which it gives rise, to leucorrhoea, or some other uterine, affection. In other cases the symptoms are more marked 38 GONORKRHGEA IN WOMEN. and indicate inflammation of the vaginal passages and of the bladder. There is redness, swelling, and heat of the external parts, attended, after a longer or shorter period, by a mucous, or milky, or yellow discharge. The inflammation, when intense, leads to erosions of the membrane, which cause much pain as the urine flows over them. In most cases the urethra is involved, and there is scalding. in making water, and if the bladder becomes affected, there is frequent desire to micturate, with the emission, in severe cases, of small quantities of blood. Much stress is laid by some authors on the difficulty of distinguishing this disease from other vaginal discharges, and the use of the speculum is invoked to clear up the diagnosis. I believe this difficulty to be overstated. The persistent heat and tumefaction of the external parts, the irritation of the bladder, together with the ordinarily undisturbed state of the patient's general health, sufficiently distinguish gonorrhoea from that irritation which attends, intermittingly, upon uterine disease, and in which the general health is, also, commonly, impaired. Treatiment.-The - same circumstances which render the disease in women less painful and complicated than in men, render it also much more amenable to treatment. Local remedies are more to be relied on, and in many cases are alone sufficient to effect a cure. "While the inflammatory symptoms run high, free bathings with cold or tepid water should be enjoined, GONORRlHEA IN WOMEN. 39 and at the same time Aconite and Aliercurius, or Cantharis, should be administered internally. As the symptoms become mitigated, Cannabis may be resorted to, and a lotion of Lead, or Hydrastis, or Alumina, may be employed as an injection. This should be used several times a day. Care should be taken to throw it well up the vagina, for the disease commonly penetrates beyond the reach of sponges or cloths, with which some patients will persist in applying the lotion. The indications for the different medicines are much the same as those which have already been pointed out in describing the treatment of gonorrhcea in the male, viz.Aconite, when there is heat and swelling of the external organs, with irritation of the bladder and frequent desire to pass water. Cantharis, if there is frequent urging to micturate, with heat and pain in the act, or when, these symptoms being absent, there is burning heat of the external parts, with or without discharge..Mercurius corrosivus, when, these more urgent symptoms having been subdued by the foregoing medicines, there still remains heat, with a milky or yellow discharge. This combination of general and local treatment seldom fails to eradicate the disease in the course of a few days. 40 CASES. The following cases, selected from a large number, are introduced for the purpose of illustrating, practically, the leading points in the foregoing remarks. It was my first intention to introduce the different cases immediately after the diseases to which, respectively, they belong. But, as the complications of gonorrhcea are so constantly mixed up with the original disease, it has appeared to me more appropriate to group the cases all together, and so preserve that unity, and natural connexion amongst them, on a view of which much of their practical value depends; and, at the same time, avoid the tiresome repetition which a different course would, inevitably, have entailed. CASE.-Balanitis, mistaken for Gonorrlhoa--Chancre. June 25th.- --, et. 24. Has had a chancre a week, on the franum preputii, and two smaller ones. The whole membrane covering the corona glandis, and the adjacent part on the prepuce, is terribly inflamed, and discharging a quantity of pus. He has been treated for clap, and has had balsam of copaiba, which he could not keep on his stomach. Take Mer. solub. %, gr. iij, ter die. To wash away the matter from under the foreskin with syringe and warm water, and then throw up Calendula lotion, the foreskin being thick, inflamed, and very tight, and painful to retract. 29th.-Considerable improvement. Continue. July 9th.-Still progressing favorably. Continue. 15th.-The chancre still felt, hard, through the foreskin. The discharge from under the prepuce almost entirely subsided-scarcely CASES. 41 more than would come from the chancre. He continued the lotion and the Mer. sol., and got steadily well, without any untoward symptom, either then or afterwards. This case is a practical illustration of an error in diagnosis, which has before been alluded to as possible, if care be not observed, viz., mistaking the discharge from an inflamed foreskin for gonorrhoea. CASE II.-Balanitis-Gonorr1coea-lErysipelas of Penis, and Crabs. June 17th.- -, mt. 24. Had connexion a month since. The discharge first appeared a week ago. It is now copious and milky, and there is scalding after passing water. Take Copaiba X, gtt. xv, ter die. 25th.-The discharge considerably less. The scalding nearly as much. Continue. July 3rd.-The last time he visited me he had a wash, composed of two grains of Hydr. bichlor. to an ounce of water, for a colony of crabs, which were destroyed by two applications of the poison. He has now a copious purulent discharge from the under side of the prepuce, the result of inflammation set up by the accumulation, in that situation, of smegma and gonorrhoeal discharge. The foreskin is swollen by an attack of erysipelas, evidently originating in the balanitis. To have Bell. and Mere. corrosiv. tinctures, x, alternately, once in six hours. Apply cold cloths to penis. 13th.-The above symptoms have subsided. Still some gonorrhceal discharge. To take Tinct. Cannabis 0, gtt. x, ter die, and use Lotio Plumbi as injection. With this treatment he got quite well in a few days. CASE III.-GonorrlAa, with Balanitis and Ulceration. December 7th.- -, at. 24. Eight days a yellow discharge from the urethra, having had sexual intercourse six days previously. 42 CASES. Six days ago a superficial ulcer appeared on the corona glandis, He applied Caustic to it, and it is now sloughy at the bottom. The whole lining membrane of the prepuce is inflamed, and there are other superficial ulcerations on the glans. He has had Cannabis three times a day, and the discharge had nearly ceased until to-day. Take Mere. corrosivus j, ter die, and apply Calendula lotion, on cotton wool, to the prepuce. 12th.--The large ulcer, which was touched with Caustic, healed; and the inflammation of the glans and prepuce has nearly disappeared, with the exception of one small soft ulcer on the edge of the prepuce, which does not heal. There is still some discharge and slight irritation. Continue medicine, and have RTydrastis infusion to inject. 17th.-The discharge, the next morning after the fydrastis injection, seemed to have gone as by magic. He has used it three times a day. There is now the slightest discharge. The ulcer is not quite healed. The granulations are weak, and bleed every morning, when the dressing is renewed. Touch them with Caustic, and continue the medicine. 26th.-The ulcer has healed. He took wine yesterday, and today the prepuce has become inflamed, is discharging yellow matter, and there are some superficial ulcerations. Take Nitric acid X, gtt. v, ter die, and apply Calendula lotion. January 9th.-The irritation, though much less, continues, and the ulcerated spots are a little elevated. Take Mer. sol. 2, gr. ij, ter die. 21st.-The ulcers healing rapidly. The irritation ahnost entirely subsided. Continue. 31st. The gonorrhcea well. The ulcers healed. The irritation also is only of the most trifling character. Repeat medicine. Cured. CASE IV.-Simple Gonorrltaa, cured in its initial stage. July 29th.- - Coition four days since. There is tickling at the orifice of the urethra, and a slight discharge just commencing. 44 CASES. A few months later, he contracted a similar attack, treated it in the same way, and got well in a week; and on a third occasion of a like kind he was equally fortunate. His attacks are mild. In such cases, the use of injections sometimes answers. As a rule, I have found them fail, and in some cases they increase the irritation. CASE VIII.-Simple Gonorrhoea, cred by Cannabis and Injection. January 8th.- -, set. 29. Has had gonorrhoea ten days. There is simply yellow discharge, without irritation of any kind. To take Tinct. Cannabis, 0, gtt. x, ter die. 24th.-The discharge ceased after four days, and continued so for a week; three days since it returned slightly. To use Lotio Plumbi twice a day. February 28th.-Has been quite well up to this time. CASE IX.-Simple Gonorrhoea. March 19th.- -, aet. 30. Coitus nine days ago; discharge appeared six days ago. He had rheumatism following a former attack three years ago. He had, also, inflammation of the testicle, after using a strong injection. There is, now, a copious yellow discharge, with cutting in passing water. He has had three bottles of Balsam of Copaiba mixture, which has in no way controlled the disease. To have Aconite and Mercurius of the third decimal, alternately, every four hours. 22nd.-The same, or nearly so. Tinct. Cannabis sat. 0, gtt. x, ter die. 28th.- Considerable improvement; less discharge, and less scalding. Continue. April 5th.-Still some discharge, no scalding. Continue, and inject Lotio Plumbi every night; 12th.-Wonderfully better. There is no discharge. This case illustrates the evil of strong irritating injections used too early, and their benefit when employed after inflammatory symptoms have been subdued. CASES. CASE X.-Gonorrkcea-Failure of njections in first stage-Cured by Cannabis and Injections later. February 10th.-Had intercourse nine days since. Two nights ago, on going to bed, had a shivering fit, and in the morning a slight milky discharge appeared. It continues much the same, with a tingling after passing water, at the end of the urethra. To take Aconite x, and Merc. corrosivus x, pilules, alternately every four hours, and use injection of Liq. Plinbi two or three times a day. 17th.-The injection did no good, but caused much irritation, and he left it off after the second day. There is now copious yellow discharge; not much irritation. Take Tinct. Cannabis 0, gtt. xv, ter die. 24th.-Very great amendment. There is but little discharge; no irritation. Continue medicine. March 3rd.-Still less discharge; no irritation. Continue, and use same injection as formerly, every night. 10th.-Scarcely any discharge at all. Continue. He had one more repetition of the medicine, and was well. CASE XI.-Acute Gonorrhola, with Irritation of the Bladder. May 6th.- -, at. 23. Has had gonorrhcea a fortnight, and has been under allopathic treatment all the time. The remedies have purged him severely, and reduced his strength so much that he can stand it no longer. Yesterday his medical attendant ordered eight leeches to be applied over the pubes, for irritation of the bladder, which has existed three days. There is heat in the bladder, almost incessant urging to pass water, and scalding all along the urethra. The discharge is copious and yellow. Take Aconite -, and Canth. -, alternately, every four hours. 15th.-Was better two or three days. Again pain at the end of the urethra, and frequent desire to micturate. Continue medicines. 23rd.-Very much better indeed. No pain. The bladder entirely relieved. Discharge less in quantity. Take Cannabis sat. q, gtt. x, ter die. CASES. 31st.-Still some discharge. No irritation. Continue to use Injectio Plumbi, om. nocte. He continued the injection a few days longer, and took, at last, Tinct. Sulphur, and was quite well. CASE XII.-Acute Gonorrhiea, complicated wOith Irritation of Bladder and Erysipelas of Penis, and slight Stricture. July 1st.- -, et. 41. Has had gonorrhea three days; slight milky discharge, with irritation of the end of urethra. Take Aconite k, and Mercurius corrosivus ', alternately, every six hours. 4th.-A good deal of scalding, more copious discharge, mixed with a little blood; there is also frequent desire to pass water. Take Aconite and Cantharis, each the third decimal, a drop, alternately, every six hours. 13th.-Amelioration of most of the symptoms. Take Tinct. Cannabis 0, gtt. x three times a day. 18th.-Violent headache, quick pulse, chills, feverish. The discharge much the same, and the prepuce and body of the penis attacked with erysipelas. The whole organ is enormously swollen, and intensely red. Take Belladonna tinct. k, and Aconite ', alternately, every four hours, and apply cold-water cloths to the penis. 22nd.-The erysipelas subsiding. Better in health. Discharge -and scalding less, but he has frequent watery diarrhoea. Take Veratrum x, every four hours. 25th.-Well of the diarrhoea, and altogether better. Still a free discharge, but very little irritation. Resume Tinct. Cannabis, and use Lotio Plumbi injection every night. From this date, chiefly with these remedies, he gradually improved. The discharge was reduced to the smallest quantity, yet in that small quantity it persisted, at one time being yellowish, at another colourless. The stream of urine was a little contracted and twisted. Suspecting slight stricture, I introduced a No. 6 bougie. There was considerable obstruction. Neither this bougie nor a smaller one would pass, the first time. At the second attempt it entered the bladder, and in two or three times more he was perfectly well. CASES. 47 CASE XIII.-Acute Gonorrhoka-Orclitis-Allopathic treatmentCured by Aco., Canth., and Pulsatilla. June 14th.- -aet. 22. Has had gonorrhea ten days, and under allopathic treatment all the time, taking Mag. carb. and Sulph., and Vin. Ant., Pot. tart., with no good effect. There is now a copious, thick, greenish-yellow, discharge, with pain about midway up the urethra after passing water, and irritation of the bladder, and occasional chordee. To have Tinct. of Aconite, and ditto of Cantharis; a drop of each of the third attenuation, alternately, six hours apart. 21st.-Nearly all the above symptoms have disappeared. No irritation of urethra and bladder, no chordee, the discharge much less and not so green. To have Tinct. Copaiba x, gtt. xv, ter die. July 5th.-By report from the country, he has been undergoing much exertion, and drinking freely of beer, and the discharge and scalding have returned. To have, first, for three days, Aconite and Cantlharis as before, and then Cannabis sativa 0, gtt. x, ter die. 9th.-By report, laid up with inflamed testicle, much swollen, red, very painful. To have Tinct. Aconite X, and Tinct. Puls., two drops of each, alternately, at four hours intervals. 16th.-No pain in testis; able to get up; a very little discharge. Continue the medicines, with which he entirely recovered in the course of a week. CASE XIV.-Gonorrlhoa, with Inflammation of the Testicle. November 12th.- - Has had gonorrhoea six weeks, rather severely. He has taken Balsamn of Copaiba, and, latterly, saline aperients. There is copious yellow discharge, not much scalding. Take Cannabis sat. <, gtt. xv, ter die. 16th.-Much the same. Continue. 21st.-Nearly well. No discharge yesterday; a little moisture to-day.,No inflammation. Continue medicine. 48 CASES. 28th.-Pain and swelling of the left testicle came on two days since. To have Aconite -, gtt. ij, and Puls. x, gtt. ij, alternately, 4tis horis. 30th.-Testicle much swollen, but easier. The discharge has returned slightly. To enter the London Homocopathic Hospital, where the same treatment was continued under my own care. He recovered completely, in a few days, from the orchitis. The discharge, which continued in a slight degree after he quitted the hospital, was cured by Liq. Plumbi injection. CASE XV.-Gonorrhoea, with Inflamed Testicle. This patient had gonorrhoea five weeks; was under allopathic treatment. On the 21st of August I saw him, with inflamed testis. He had then been confined to bed four days, and had been treated rather severely with Calomel purgatives, lotions, &c. The organ was very much swollen, hard, and tender; the pain extended up the cord to the abdomen and loin; he was sick and feverish and thirsty. I gave him Aconite X, and Pulsatilla x, alternately, every four hours. The discharge ceased with the accession of orchitis. Amendment set in immediately with the commencement of the treatment, and on the third day he was able to get up. No alteration of treatment was required, and he rapidly recovered. The discharge returned in a slight degree, and was checked by Cannabis and Mercurius corrosivus; and lastly, an injection of Liq. -Plumbi in aqua. CASE XVI.-Gonorrhlea-Warts at the Anus. May 16th.---, at. 19. Applied to me a fortnight since for wnat appeared to be an attack of low gastric fever. He had languor, headache, loss of appetite, foul tongue, looseness of the bowels, &c. He was compelled to relinquish his occupation and remain at home. The treatment I adopted failing to relieve the above symptoms, the suspicion arose that something undivulged by him, was keeping up the stomachic irritation. It then appeared that he had had gonorrhcea two months, for which he had been taking large quantities of Copaiba and other medicines, which he still continued to take; CASES. with no other effect than to disturb his general health. There is still considerable discharge, though but little pain. To take Cannabis. 0, gtt. x, ter die. 20th.-Very much better in health. The discharge less copious. Continue medicine, and use injection twice a day of Lotio Plumbi. 29th.-Scarcely any discharge. He has passed blood, and suffered great pain, at stool, the last week or ten days. On examination, a luxuriant crop of warts is found encircling the anus. I snip these off, and apply dry lint, and give Thuja c, gtt. v, ter die, with which, and a continuance of the injection for a few days longer, he perfectly recovered. CASE XVI1.-Spuriozs Gonorrhcea in an irritable subject, with Prostatitis, and Orchitis, and Irritation of Rectum. This gentleman had been under care some time for chronic prostatitis. There had been irritation of the bladder, too frequent desire to pass water, and the discharge, from time to time, of transparent mucus. These symptoms had been much benefited by Aconite, Cantharis, Mere., Sldphur, and other remedies. At length it was thought desirable to pass a bougie. This was done, with but very slight obstruction, and very considerable relief to the above symptoms: more decided relief, indeed, than had been obtained by any other treatment. Suddenly, after the bougie had been introduced about six or eight times, violent irritation ensued. All the symptoms of fresh genuine gonorrhoea were set up-copious milky discharge, intense inflammation of the orifice of the urethra, scalding. The irritation extended along the urethra to the bladder; there was constant and painful urging to pass water, with the discharge of blood. To this succeeded inflammation of the prostate, marked by pain, at first sharp, and subsequently heavy, and aching, in the perinmum, with great tenderness on pressure over the gland, and inability to sit or stand; there was, also, partial retention of urine. This state of things lasted for some time, and during its progress one of the testes became inflamed, painful, and very large. The rectum was the next and last part affected. There was constant urging to stool, great pain 4 52 CASES. little discharge indeed. Again bougie; less obstruction. Continuemedicine. 18th.-Very little discharge. Treatment the same. This was repeated two or three times more, and he had no further annoyance. CASE XX.-Stricture, withi Fistulous Openings in the Perincaum. A gentleman, et. 40. Had gonorrhoea several years since, of an acute nature. Had for a long time been troubled with his water, being unable to pass it except in the smallest stream. He had undergone a good deal of treatment by different medical men, with only temporary relief. The symptoms increased; he passed water only in driblets, after much straining. Abscesses formed on the perinmum, and fistulous openings remained, through which the urine escaped. There was the most frightful irritation of the bladder, incessant desire to micturate, and the discharge of highly ammoniacal, muco-purulent urine. His health was completely broken by pain and want of rest; any attempt to pass a catheter in his then condition was attended with the greatest agony. To have Aconite and Cantharis, alternately, every four or six hours. These medicines formed the base of the treatment. He had from time to time Sulphur and Nux; and Belladonna for one or two attacks of erysipelas in the perinmum, which was caused by the irritation of the urine, escaping through the false opening. The irritation of the bladder was speedily allayed by the remedies; the urethra became tolerant of the catheter. After several cautious, but fruitless, attempts, a passage into the bladder was effected. This advantage was maintained; the stricture yielded entirely,-the openings in the perinmum closed, the urine passed the natural way, the patient's health became perfectly restored, and has remained good ever since, now a space of six. years. 05 6 PRIMARY SYPHILIS. white, and sharp, and subsequently, when the healing process commences, they become rounded, and red. The bases of these ulcers are commonly covered with a lardylooking substance. They discharge, freely, rather a thin, ichorous fluid, or yellow matter. The parts surrounding the ulcer are sometimes inflamed, but seldom much thickened. The soft chancre engenders suppurating bubo, but:seldom, if ever, infects the constitution. HARD CHANCRE is not commonly distinguishable from the soft chancre for the first twenty-four or forty-eight hours. The change into its characteristic hardness is gradual, and manifests itself about the third day, or a little later. The hardness, when specific, cannot be mistaken. The soft chancre sometimes becomes slightly indurated, but it is very different from the hardness of the true Hunterian chancre, which, when passed between the finger and thumb, feels like a piece of cartilage. The hardness seems to depend on plastic deposit into the tissues surrounding the ulcer. It remains during the whole course of the disease, and for some time after. The shape of the hard ulcer'differs greatly from that of the soft.. Its edges are seldom raised above the surface, but commence abruptly, and pass in a shelving, sloping, direction to the bottom of the ulcer, which dips down deeply into the subjacent textures, and thus acquires its well known, contracted, cup shape. The surface of PRIMARY SYPHILIS. 57 the ulcer, instead of looking moist, and discharging freely, like the soft chancre, is generally dry, or covered with a kind of scab. Hard chancre is frequently attended with induration of the inguinal glands, which feel like a row of flattened peas under the skin; but they seldom suppurate. This kind of chancre is the parent of the much dreaded secondary symptoms. But few cases of this disease pass off entirely without being succeeded, sooner or later, by some manifestation, more or less severe, of this constitutional taint. There is a form of ulcer, intermediate between the soft and the distinctly hard chancre, called the elevated ulcer. It is generally raised considerably above the surrounding surface, almost like a large wart, the mass being formed by thickened and somewhat hardened integument. Considerable inflammation of the contiguous parts accompanies this form of chancre. It is slow to heal. Though differing considerably, in form and appearance, from the true Hunterian chancre, it partakes of its nature, inasmuch as it is very apt to be succeeded by secondary diseases. PHAGEDJENA-DESTRUCTIVE ULCERATION-is less a separate form of chancre, than a condition supervening upon other chancres during their course. The soft chancre is more liable than the hard to become phagedaenic, and the change is generally due to bad health at the time 58 PRIMARY SYPHILIS. of infection, or to some unfavorable circumstances occurring during the progress of the disease. About a year ago I had a case under care, which will be found detailed. in a subsequent page, in which, after the ulcer had nearly healed, the disease suddenly took an unfavorable turn, broke out afresh at the root of the penis, and threatened the entire destruction of the genital organs. The only cause I could assign for this change, was the acute mental anxiety the patient suffered, from fear of the nature of his malady being detected by his family. This destructive form of the disease is not frequently met with in private practice, and amongst respectable patients; but it is not uncommon in hospitals, amongst prostitutes and men inhabiting close, unhealthy localities, and who lead irregular and intemperate lives. I am persuaded, however, judging from the rarity of phagedmna in homoeopathic practice, and from what I know of the effects of large quantities of mercury, that this medicine, administered as it is administered by allopathic surgeons, is one of the most prolific exciting causes of phagedsenic ulceration. The depressing influences above alluded to, and a scrofulous constitution, are-the chief predisposing causes. The symptoms of phagedaena vary so much in different cases, that it would be difficult to give such a description of them as should embrace all its phases. Its leading characteristics are-the irregular shape of the ulcer; its jagged and irritable edges; its angry appearance; its painfulness; the thin, ichorous discharge that comes from it; and, its tendency to rapid and persistent extension. PRIMARY SYPHILIS. 59 In spite of all that can be done to arrest its progress, it will sometimes continue to spread until large portions of the genital tissues are disorganized. Some time since a case of this kind was brought to me by a provincial colleague, in which the whole of the foreskin, and a considerable portion of the glans penis, was already destroyed, and still the ulcer was spreading; and I recollect seeing a case many years since, in which one testicle was entirely denuded of its scrotal covering, by an ulcer of this kind. URETHRAL CHANCRE, is simply an ulcer situated at the orifice, or within the canal, of the urethra. This form of the disease is chiefly interesting, on account of the light it sheds upon a disputed point connected with the supposed appearance of secondary symptoms after gonorrhoea. Patients who were never known to have had primary syphilis, but who had slight discharges from the urethra, were affected with secondary symptoms. This discharge was supposed to originate in gonorrhoea, the secondary symptoms were attributed to it, and the inference was drawn from the two circumstances, that syphilis and gonorrhoea were one and the same disease. The error is explained, by the detection of urethral chancre. I have now under care a case of tertiary node of the ulna, in a gentleman who has also had secondary eruptions, but who was never known to have chancre. He had, however, many years ago, a slight discharge from the urethra, which, being regarded as a clap, was treated -60 PRIMARY SYPHILIS. with Copaiba and injections. This was, doubtless, urethral chancre. Such cases suggest the propriety of examining the urethra when cases of slight discharge of thick, yellow, pus from that passage come under the surgeon's notice. The gonorrhoeal discharge is thinner, milky, and more copious, even in mild cases, than that from an ulcer. There is no fear of such an error in diagnosis in acute gonorrhaea. These ulcers are found just within the urethra, at a very short distance from the orifice. They are generally flat and superficial, and nearly of the same colour as the mucous lining of the canal. Whilst little disposed to spread or become hard, they are yet slow in healing, owing, probably, to the passage of urine over them, and to the constant contact of the opposing surfaces. This contact may be obviated, in the treatment, by the insertion of a small piece of cotton wool, carrying Calendula, or other, lotion. Urethral chancres are said to be occasionally situated higher up the passage. This I should think an exceedingly rare occurrence. It is not easy to understand how the virus could _be conveyed thither, nor how, except by inoculation with the discharge, the existence of the disease could be verified. Treatment of Primary Syphilis.-We have now to consider the treatment of primary syphilis. The object to be had in view is to heal the ulcer before the system has become contaminated. To this PRIMAIRY SYPHILIS. by the old and the new school of practitioners, the difference consisting mainly in the dose, and this is an allimportant difference. The old plan is-mercury to salivation. Now, on the very threshold of this matter we encounter a notable inconsistency in the teachings of allopathic writers. Mr. Druit, who in his 'Vade Mecum' may be regarded as expressing the general opinion of the body to which he belongs, says, " Not that this," that is, salivation, "is of any use, except to show that the system is affected; because," he continues, "the action of the mercury must be kept up until the ulcer heals, and all hardness in the part disappears." This is not only inconsistent, it is purely absurd. If the healing of the ulcer, and the disappearance of the hardness, be the true test of cure, on what conceivable ground is it laid down as a law, that mercury must be given until the mouth is made sore? Of two things let us have one. If salivation be the standard, adhere to it; if the healing of the sore, and the absence of hardness, then hold by them. If the disease be cured, why, in the name of all that is reasonable, should the unhappy patient be doomed to salivation, which, according to Mr. Druit's own confession, is useless, except to show that "the system is affected?" The system affected! Herein lies the whole fallacy. It is assumed that the sore will not heal, nor the hardness subside, unless the system is affected. Strange, that it should never have entered into the heads of our learned brethren to test this point-to try whether the disease might not be cured without affecting the PRIMARY SYPHILIS. 63 system! There is no fact in science better established than this, that syphilis may be as thoroughly, as quickly, and as effectually cured by mercury in doses short of salivation, as by mercury in those poisonous doses which "affect the system." This, from Hahnemann's time up to the present, has been proved, over and over again, in thousands of cases, in the practice of homceopathic surgeons. I, myself, during the last sixteen years, have treated more cases of syphilis, in all its forms, homoeopathically, and have made better cures, than I did during the previous fourteen years of my allopathic practice. The whole question admits of demonstration. There is no mistake about the disease. It is open to our view. The progress of the cure, and the result, are equally patent. There is here no room for cavil. Whatever arguments may be made use of to explain away the effects of homeopathic remedies in other diseases, are here totally inadmissible. Time, nature, and imagination, which, in the opinion of our opponents, come so generously to the rescue of the homoeopath in other cases, will hardly be invoked in a case of chancre, even by our bitterest opponent. A chancre is a fact, and a stubborn fact, too, unless it is well treated. Homoeopathic patients, unfortunately, enjoy no exemption from these facts; and if our doses of mercury do not cure them, then we may fairly ask to what agency their cure is due; for, that they do get well, no one will dispute; and the patients themselves shall be our judges, whether or not they have been subjected to such doses of mercury as affect the system. 64, PRIMARY SYPHILIS. Admitting, then, that syphilis is curable by innocent doses of mercury, the force of such an admission, in modifying the ordinary mode of treating the disease, is as apparent as it is irresistible. Is any one ignorant of the effects, present and prospective, of salivation? Are those effects not as familiar to our ears as household words? and their associations, are they not those of long-suffering wretchedness? Is it nothing to. be able to avoid all this? Is it not, rather, one of the greatest boons that can be conferred upon erring humanity! This boon homceopathy does confer? and not only so, it places us at an immense advantage in the management of the disease. With allopathy it is a matter of vital importance to the patient that the surgeon be able to distinguish, at once, and with unerring certainty, between a venereal and non-venereal sore, because, upon this decision depends the question, whether he is or is not, to be salivated. If non-venereal, he will be treated with a cooling dose, and some bland lotion; if venereal, he must have mercury. But it is sometimes very difficult, if not impossible, to determine the true character of a sore. The patient, here, cannot be allowed the benefit of the doubt. If you err, err on the safe side, says the allopath. Better salivate twenty innocent men, than let one guilty one escape! But with the homoeopath the case is quite different; he acts upon the simple law that "like cures like." He knows that mercury cures ulcers on the skin, and venereal ulcers amongst others, in virtue of its property to produce ulcers in healthy subjects; and, if a PRIMARY SYPHILIS. 65 patient present himself to him with an ulcer on his penis, I do not say that he is indifferent as to its nature, but, whether he be able to determine this point or not, whether the sore be venereal or non-venereal, he will probably prescribe mercury, for the simple reason that it is the right remedy. It is, then, not only unnecessary, it is in many cases positively injurious to the progress of the cure, to affect the system with mercury. Salivation, by inducing mercurial fever, irritates the ulcer, retards granulation, and tends towards the production of that most destructive and much dreaded form of the disease, the phagedsenic ulcer. Upon the system its effects are equally deleterious; it sets up general fever, destroys the appetite, and causes diarrhoea, dysentery, and ulceration of the mouth and throat. As regards the indications for the use of this remedy, whilst it is, certainly, most imperatively demanded in the indurated ulcer, I considerit as suitable, at times, to all kinds of chancres. Even in the phagedmenic, in which its use is generally thought to be contra-indicated, I have known it to arrest the ulceration when other remedies, ordinarily recommended for that condition, have failed. In the old school there is so much dread of the effects of mercury that every opportunity is seized of avoiding its use, except in the case of hard chancre, in which it is regarded as indispensable. I have already shown such apprehension to be totally out of place in homoeopathic practice; and, on that 5 66 PRIMARY SYPHILIS. account, as well as on account of its being beyond all others the most efficacious of remedies, I do not hesitate, whenever a patient presents himself with a suspicious-looking sore on his penis, to give mercury at once, if it has not already been administered in large quantities. There is no doubt that some soft, superficial, ulcers will heal readily enough under the action of other medicines, or even -without any medicine at all, and that mercury is most imperatively demanded in the indurated chancre; yet, I have treated many cases of soft chancre without mercury, in which,ultimately, I have been compelled to resort to that medicine, either because the healing process did not commence, or because granulation, having proceeded to a certain extent, came to a standstill. The conclusion, therefore, at what I have arrived, after carefully testing, and watching the effects of different remedies, is this that the surgeon who relies most on the proper and judicious use of mercury, will cure, expeditiously and permanently, the largest number of chancres. Then, as regards the form of the medicine, I am decidedly of opinion that the black oxide of Hahnemannthe.Iferc. Sol.-is the best. In the primary chancre, I seldom employ any other preparation, and it rarely fails me. And as regards the quantity, I am satisfied that a considerable modification of the doses ordinarily recommended in homoeopathic books, is requisite. These quantities I believe to be too small. It must not be lost sight of that, in treating syphilis, we have to PRIMARY SYPHILIS. ý67 d<eal, not with a disease consisting in simple functional disturbance, or in structural alteration arising therefrom, such, for example, as takes place in common phlegmasia, but with a disease engendered, palpably, by the local or constitutional operation of a virulent poison. In the former case, a medicine in exceedingly small doses, acting through the agency of the nervous force, is generally sufficient to rectify the diseased action. In the latter, a poison has to be neutralised, and, to effect this, the remedy requires to be administered in quantities, which, though still very small, are considerably larger. Careful observation has convinced me of this necessity, and one or two striking illustrations of it will be found amongst the cases of syphilis. The dose which I commonly employ, and which I have found very effectual, is two or three grains of the first or second decimal dilution, repeated threetimes a day. I sometimes commence with the former, and continue it for a week, or until amendment sets in, and then replace it by the second dilution. More commonly, I give the latter only, and resort to the first dilution chiefly in cases of obstinate indurated chancre. There is one error against which I must here caution the young homoeopathic practitioner-that, I mean, of too hastily changing the treatment. Let him persevere steadily in the use of a well chosen remedy, and this perseverance will more surely be crowned with success, than will that vacillating impatience which leads him to vary the remedy with.every variation in the outward appearance of the disease. 68 PRIMARY SYPHILIS. In no case does this apply more forcibly than in the treatment of syphilis, and in the homoeopathic use of mercury. Other preparations of mercury, if the surgeon prefer them, may be employed in the cure of chancre-the Mlerc. viv., the Merc. corrosivus, the Proto- and BinIodides. The latter may be advantageously given to scrofulous patients, and in cases where the primary sore, and secondary symptoms, coexist. But, on the whole, I conceive the iodides to be best suited to secondary and tertiary syphilis. The triturations of these, as well as of the black oxide, I regard as more certain in their operation than the spirituous solutions; in which form, moreover, the medicines cannot be administered in such low potencies, as in trituration. Acidum nitricum.-This is another great syphilitic remedy, second only to Mercury in its power of neutralising the effects of syphilitic virus. In their dread of Mercury, the members of the old school are ever casting about to find substitutes for that medicine; and of these, Nitric acid has been lauded as one of the most powerful. Now, according to the strict application of the homeopathic law, no one medicine can be, properly speaking, a substitute for another; and, in the treatment of syphilis, so far from Nitric acid being a substitute for Mercury, it has, like Mercury, its own peculiar sphere of action, which no other medicine can fill. Thus, whilst Mercury is the proper remedy for chancre, and particularly for hard chancre occurring in persons of PINIMAItY SYPHILIS. 69 good constitution, who have not previously been poisoned with Mercury, Nitric acid is as distinctly the proper remedy for chancre, and particularly for soft chancre, in persons of weak and debilitated.constitution, whether that condition be the result of scrofula, or of the noxious influence of Mercury, or of a previous venereal taint. This distinction being kept in view, it is at once apparent, that we could as little spare the one medicine as the other. Mercury is more frequently called for than Nitric acid, simply because the class of cases to which it is applicable are more numerous. Syphilis is most commonly contracted by the young, the ardent, and the vigorous. But, on the other hand, the cases are by no means few, in which the disease is contracted by those of an opposite temperament; and more numerous still are those cases which occur in persons whose constitutional powers have been undermined by the combined influence of Mercury and syphilis, in previous attacks. In these cases, Acidum nitriczim is, generally speaking, the appropriate remedy. As I have before remarked, venereal diseases, being exceptional in their nature, require to be exceptionally treated as regards the doses of some of the remedies. Formerly, I was in the habit of administering, in these cases, the minutest doses of Acid. nitric. The effect, if not altogether inappreciable, was, at least, very uncertain and unsatisfactory. Latterly, I have prescribed 70 PRIMARY SYPHILIS. it in doses of from five to ten drops of the second decimal] dilution, with very decided advantage. The alternate action of the two foregoing remediesMerccry and Nitric acid-when either of them, singly, seems inoperative, is sometimes very useful. Thus, commencing the treatment with Mercrizus, the ulcer beginning to heal, has, at the end of ten days or a fortnight, come to a standstill, or has retrograded. Acid. nitricum has instantly restored the healing process; which yet, again, after the lapse of a few days, has required the resumption of M-ercurius to complete the cure. Other medicines are named in homceopathic books as remedies for chancre, such as Arsenicum, Argentun zitricum, Corallia rubra, Causticea, loditn, Staphysagria, Thuja, Sulphur, 4#c. I can quite understand that Arsenicum might be useful in some forms of phagedena; lodiium in scrofulous subjects; Thuja in condylomatous growths; Sulphur as an intermediate remedy; and Argentum nitricum, we know, is useful as an external application. But I should certainly hesitate to trust to either of these remedies in the treatment of hard chancre; and even in soft chancre, I should feel greater confidence in Mercurius and Acidum nitriczun. It is doubtless one of the just boasts of homeopathy, that it has a rich repertorium, and is not confined to a single remedy in the treatment of any disorder. It should equally be the boast of the medical man, to cure with the smallest possible number of medicines. His results are then more satisfac PRIMAIRY SYPHILIS. 71 tory to himself, and his experience more useful to others. Local treatment of syphilis.-Much may be done in this respect, to check ulceration and favour the granulating process. When the ulcer is not placed beyond our reach by a contracted foreskin, a piece of cotton-wool, soakedin cold water, or weak Calendula lotion, should be applied to the part, and changed twice a day; and if, in consequence of phimosis, the chancre cannot be got at, the foreskin should be well washed out, by means of a syringe,, first with warm water, and then with Calendula lotion. "When a patient is so situated that he cannot procure Calendula, the Lotio Nigra is a useful application; but when it can be procured, the Calendula is greatly to be preferred. I have seen sluggish ulcers stimulated into active and& healthy granulation in the course of a few hours aftercommencing the use of this lotion. In phagedmnic ulcers, it is of the utmost service in allaying irritation, soothing pain, and checking the ulcerative process. A light touch of Argqentmz nitricum, in its solid form, is also a useful stimulant to sluggish ulcers. BuBO: inflammation and enlargement of the inguinal glands, which may end either in resolution or in suppuration. Bubo is said to be gonorrhoeal, or syphilitic. In the former case, which is very rare, it is purely sympathetic; in the latter, which is very common, it depends on absorption of the syphilitic virus from a chancre. PRIIMARY SYPHILIS. Gonorrhoeal bubo is commonly excited by exercise. In first cases, in which the symptoms are apt to run high, the patient should be cautioned to remain as quiet as possible. Gonorrhoeal buboes very rarely suppurate, and yield readily to rest, and the application of cold compresses, or cold bread-and-water poultices. The most appropriate medicines are Aconitum and M]fercurius. The syphilitic bubo is a more important affair. It arises, as I have just said, from the absorption of the virus from the primary ulcer, and is greatly influenced in its character and course, by the nature of the ulcer to which it owes its origin. Thus, the soft, freely discharging chancre begets the suppurating and sloughing bubo; the indurated chancre is accompanied by indolent induration of one or more of the inguinal glands, which seldom form into matter. This further interesting conclusion has also been arrived at, viz., that secondary symptoms rarely follow a suppurating bubo, whilst the hardened glands that attend upon hard chancre, indicate that the system [is already contaminated with the syphilitic poison, and that other secondary symptoms will almost inevitably follow. The soft, non-infe6ting, syphilitic bubo, as a rule, is not attended with great pain or inconvenience. The patient is generally able, from first to last, to keep about, and occupy himself as usual. It is, moreover, exceedingly prone, in spite of all our efforts to the contrary, to suppurate. Indeed, so commonly have I found this to be the case, that, beyond the application of cold water, I now rarely direct any treatment especially to it. If it be PRIMARY SYPHILIS. 73 not arrested by the treatment proper for the original disease, I despair of arresting it by any other means. It is better to leave it alone until it is nearly ripe for opening, then to apply a linseed-meal poultice for a few hours, and evacuate the matter with a lancet. This should be effected at the earliest possible period. The destruction of tissue is then inconsiderable, and the wound made by the lancet is small and clean; and under favorable circumstances, the whole affair is over in the course of a few days. But, if the matter be allowed to accumulate until it finds an escape for itself, or until the skin is deeply and extensively implicated, then a large, irregular wound is established, the cavity of the abscess is exposed to the irritating influence of atmospheric air, and extensive sloughing is apt to ensue. In ordinary cases, little more is afterwards required, than the application first of a few linseed-meal poultices, and then of cold water, or Caledula lotion dressings. In other cases, occurring in scrofulous habits, and especially if the opening has been too long delayed, the wound, instead of healing kindly, becomes irritated and inflamed, and the inflammation extending to contiguous parts, fresh openings are formed, until at length the whole inguinal region is occupied by a series of unsightly holes, and burrowing ulcers. This is the PRAGEDIENIC BUBO, which is often so troublesome and difficult to heal. It demands the most careful management, both local and constitutional. The former consists, first, in the use of warm linseed poultices; and, secondly, SECONDARY SYPHILIS. 75 severity, situation, and duration. They affect most commonlythe skin, the mucous lining of the mouth, the throat, the nose, and the structures of the eye. They make their appearance either whilst the primary sore is yet open, or within the space of a few weeks, or months, after it has healed. Although relapses of the same attack are very common, the first infection-like the infection of smallpox and measles-seems to render the system proof against a fresh invasion of these symptoms, from any subsequent attack of primary syphilis. These diseases are transmissible from one person to another; from husband to wife; from parent to child. I have recently seen examples of both these modes of transmission. A young man had secondary symptoms; was treated, and pronounced cured. He married three months afterwards. His wife was delivered of a child, which almost immediately developed secondary symptoms around the mouth and nose, the anus, and on the seat. It lingered, wasted, and died. The mother was not infected. I have at the present time under care, a lady who has contracted secondary symptoms of the most distinct and marked character from her htsband, who was cured of chancre before he married, but in whom secondary symptoms have since developed themselves. Men should never marry, after having had hard chancre, until sufficient time has elapsed to test the probability of their having secondary diseases. These diseases may be communicated in other ways, also. Some time ago, there was an interesting case at the SECONDARY SYPHILIS. 77 practice of homoeopathy confirms the opinion; since it is amply verified, that secondary symptoms occur after homceopathic treatment, much less frequently, and in much milder and more curable form, than after salivation. Improper diet, especially indulgence in spirituous drinks, during the treatment of the chancre, also operates as an exciting cause. Insufficient treatment, and the consequent imperfect cure of the primary sore, is another fertile source of secondary disorders. Treatment should, in all cases, be continued until the last traces of hardness in the cicatrix, have disappeared. The diagnosis of the early secondary syphilitic diseases is generally not a difficult matter. They are so well marked and distinct, and the recent existence of a hard chancre is, commonly, so easily to be ascertained, that the surgeon can hardly fail in arriving at a correct conclusion as to the real nature of these complaints. The diagnosis of chronic secondary affections is much more difficult. The history of the case is our best guide, but thelength of time at which some of these disorders will appear after infection, often envelops them in obscurity, even when the fullest information is at our command. But, it is sometimes impossible-I allude here to the cases of women-having proper regard to the feelings of the patient, to obtain the necessary information on which to base an opinion. I have recently had some female patients under care in the London Homoeopathic Hospital, with whom this difficulty occurred, but about the specific nature of whose complaints, I entertained the strongest 78 SECONDARY SYPHILIS. suspicions. Next to a correct history of the case, the obstinate persistency of the symptoms is one of the strongest confirmatory signs. Almost any chronic disorder yields more readily than old-standing syphiloid affections. Frequent relapse, after apparent cure, is another diagnostic sign of syphilis. The deep coppercolour of existing skin diseases, or of the stains left by former attacks, as alsolthe nocturnal aggravation of bonepains, are characteristic of the same taint. One of the female patients to whom I just now alluded, and who was admitted for old standing tubercular ulcerations and formations around the knee, had also copper-coloured stains on the lower part of the leg, and nocturnal pains along the shin-bones. The great attention which has lately been paid to this class of diseases, has thrown much light upon the subject, and has pretty clearly established the fact, that many anomalous symptoms and conditions of the system, which baffled diagnosis, owe their origin to a syphilitic taint. It is not my intention to enter into a lengthened and minute description of the numerous forms which secondary symptoms assume. Such a course would occupy a disproportionate amount of space, and for practical purposes is, moreover, unnecessary. The constitutional taint, there is reason to believe, is one and the same, in all the manifestations of syphilitic diseases; and modifications of treatment are demanded, less by the variations in any particular class of these diseases, than by the peculiarity of the structure which they attack. 80 SECONDARY SYPHILIS. disease be allowed to proceed, the neuralgia, which had begun in the fifth pair, attacks the seventh, and produces paralysis of the face; and if we were not guided by the chain of preceding symptoms, we might easily ascribe the whole mischief to rheumatism. I have often treated cases of this sort, and I almost always succeeded in curing them by iodide of Mercury. I have even met with instances where the seventh' pair was primarily attacked, without any previous neuralgia. After all these symptoms, sub-sternal paifis come on, which latter Baglivi looked upon as symptoms of latent syphilis; then circa-articular uneasiness, accompanied with great lassitude in the limbs, just the same as happens before eruptive fevers. These articular pains are not situated in the centre of the joint, but all around it; they are fugacious and intermittent; they do not produce any swelling or redness in the part, and are not augmented by pressure; they are vague, erratic, and nocturnal, presenting the same characters as the cephalalgia mentioned above." The skin, and the mucous membrane of the throat and mouth, are the parts most frequently affected. The symptoms follow no regular course in their accession: sometimes the throat, sometimes the skin, being the part first attacked. The secondary affections of the skin are very various, and may be ranged under the following heads, viz., exanthematous, papular, vesicular, tubercular, pustular, squamous, and ulcerative. THE EXANTHEM is one of the earliest of skin diseases. SECONDARY SYPHILIS. It is at first rosy, subsequently copper-colour. It may appear on different parts of the body in succession, or over nearly the whole surface at once. The face and forehead, the arms, chest, and abdomen, are the parts in which it commonly makes its appearance. It assumes the form of flat, even, discoloration of the skin, and hasbeen mistaken for measles, to which it bears, in itsearliest stage, a considerable resemblance. PAPULTM or PIMPLES, are another earlyform of secondary eruption. The most common is that, the top of which, after a few days, becomes covered with a fine scurf. These pimples may be pale, or red, or of a darker colourstill. On the lower extremities they are apt to be broad, flat, and of a deep copper-colour. The absence of itching in these pimples is said, by some authors, to distinguishl them from other pimples which are non-venereal, and are generally attended with much itching. I have noticed many exceptions to this rule, which is by no means general, and, if too much relied on, is apt to mislead. These pimples in some cases enlarge into circular patches or rings, the whole being covered with fine scales, constituting psoriasis. This form of the complaint, when it attacks the palms of the hands, is one of the most intractable of secondary eruptions. PUSTuTLAE AFECTIONS are amongst the later and more aggravated of the syphilitic skin diseases. They occur in debilitated and broken down constitutions, and are not uncommon accompaniments of that terrible condition known by the name of syphilitic cackexia. One of 6 SECONDARY SYPHILIS. the most inveterate and obstinate of its manifestations, is that which results in the formation of the hard lamellated scab called ru2lia. ULCERATIONS of the skin, differing from those which result from the rupture of the pustules we have just named, or from the suppuration of tubercles, are amongst the most obscure and anomalous of secondary symptoms. Yet, there is often little or no doubt as to their syphilitic origin. A very remarkable case of this kind was, admitted into the London Homceopathic Hospital about a year since. The man was covered from head to foot with hundreds of superficial ulcers, which clearly owed their origin to syphilitic taint. TUBERcLES comprise abnormal growths, in which the diseased skin is raised abruptly in the shape of warts, or in a rounded, hemispherical, form above the surface; also, flat elevations of the mucous membrane of the tongue, velum, corners of the mouth, &c., and lumps under the skin of different parts of the body. Lastly, AFFECTIONS or THE SCALP, scurfs, impetiginous eruptions, falling off of the hair, &c., must be mentioned, in this brief notice of the secondary diseases of the surface of the body. IF-LAMMATION and ulceration of the mucous lining of the throat and mouth, are amongst the earliest signs of syphilitic taint. This affection makes its appearance either early and by itself, or simultaneously with skin SECONDARY SYPHILIS. *85 manent cure. The truth, as in most other cases, lies between extremes. There is no doubt that in recent cases of secondary disease, occurring in good constitutions, and where the system has not been saturated with mercury, complete and permanent eradication of the symptoms may be safely prognosticated. On the other hand, it is equally certain that, when the taint has once entered the circulation of persons of depraved, scrofulous, and broken-down constitutions, it may but too confidently be predicted, that, though secondary symptoms may, for a time, appear to be successfully combated, relapses will occur with more or less virulence for many years, and, possibly, for the remainder of the patient's life. The treatment. in former times, of primary syphilis with destructive doses of mercury, by inducing the very state of system I have just described, had much to do with the development of secondary diseases in their most inveterate and intractable forms. Modern science, better instructed, obviates much of this mischief, by avoiding the use of mercury altogether in treating some cases of primary ulcer, and by giving it in more moderate quantities, when it is employed. Still, I am convinced there is room for yet greater improvement, and that homoeopathy points out the way to it; and, to this important point we now proceed to direct our attention. Secondary syphilis consists in the introduction of a poison into the blood; and the cure of it, in the neutralization or eradication of that poison. 86 SECONDARY SYPHILIS. The attainment of this object must be sought in the careful, judicious, and prolonged use of medicines; and in the adoption of such measures, hygienic and dietetic, as are best calculated to sustain the patient's constitutional powers. First, then, as regards medicines. It is beyond a question that, as with the original sore, so with many of the constitutional symptoms which result from it, Mercury is one of the most efficacious remedies. We constantly meet with cases in which the primary and the secondary diseases coexist, and in which the Mercury given for the one, cures the other at the same time. Several examples of this are reported further on. There is commonly in these instances this advantage, viz., that Mercury has not previously been administered, and it is precisely in such cases that the curative action of that medicine is most decided. The same thing holds good with reference to the secondary symptoms. If Mercuryhas been given to any considerable extent for the cure of the chancre, the benefit to be derived from its administration in the treatment of secondary symptoms will be much less marked, than in those cases in which it has been given in very minute quantities, or not at all. In either of the latter instances, unless there exist some special circumstance to forbid its use, Mercury is often of the utmost value in combating the earlier secondary diseases of the skin: the erythema, papules, and squamae. Over the more inveterate eruptions, it has, comparatively, but little power. When, therefore, a well-marked and un SECONDAIRY SYPHILIS. 87 doubted case of secondary eruption presents itself, following closely, or at no great distance upon the primary disease, and in which the patient has not been mercurialized, it is well to commence the treatment with one of the lower dilutions of the iodide or bin-iodide of Mercury -the second or third decimal, in two-grain doses, twice a day. This should be steadily persisted in until the eruption has vanished, or until it appears certain that the medicine has effected all the good that can reasonably be looked for from it. In many constitutions, these eruptive disorders are remarkably obstinate, and no remedy will exercise a sudden influence over them. The BMercury having had a fair trial, if it fail in effecting a complete cure, another medicine must be resorted to, and the Kalcci hJdriodicum claims our next attention. This is a remedy of undoubted power in treating the secondary diseases of syphilis; and in the majority of cases of skin affections, as well as affections of other tissues, its aid is required in expediting or completing the cure. In obstinate cases, especially those occurring in scrofulous constitutions-and they are the most obstinate-it is a good plan to give this medicine alternately with the bin-iodide of Mercury, not in alternate doses, but during alternate weeks, i. e., the Kali itydriodicUm one week, the lMercurius bin-iodidus the next, and so on. Excellent results will often spring from the alternate action of these and other remedies; and the more so, the less rapid the alternations. To obtain its full curative action in syphilitic diseases, the Kali liydriodiczum, like the ^8 SECONDARY SYPHILIS. preparations of Mercury must not be administered in too small doses. I am in the habit of giving two grains of the salt three times a day, or three grains twice a day, in aqueous solution. The principal indications for its use are-a scrofulous and debilitated constitution; enlarged glands in the groin, the throat, or neck; the previous exhibition of Mercury in excess, marked by red:and inflamed gums, sore throat, foul breath, nocturnal bone-pains. Iodium-preparations of the simple metal-may be used with advantage, in the quantity of five drops of the second decimal tincture, in water, three times a day. But on the whole, the compounds of Iodine, Mercury, and Potash, are to be preferred. Acitdum nitriczw is another medicine which has long enjoyed a wide-spread reputation in the cure of secondary symptoms. My own experience has not inspired me with unbounded confidence in its powers, in the early secondary eruptions. Like Kali hydriodicum, it is distinctly indicated in cases where patients suffer from the effects of over doses of Mercury. It is an excellent antidote to that metal; but as, under homceopathic treatment, these cases of poisoning do not occur, and when homceopathy shall become the sole system of medicine, they will cease altogether, the question arises, what, under such circumstances, will be the proper sphere of Acidum nitricum in the treatment of secondary syphilis? It appears to me that the grounds on which it is prescribed, in the early skin eruptions, are somewhat slender. I SECONDARY SYPHILIS. 89 have administered it in many cases, but the results, if not equivocal, have been by no means striking, nor to be 'compared with those obtained from the iodides of Mercury and Potash. Cases of ulceration of the mucous membrane of the throat, mouth, and nose, appear to me to be the most appropriate for the use of this medicine in the early secondary diseases. It is also strongly recommended in the treatment of Condclomata, such as spring up on the penis, and about the anus. It should be administered in from five to ten drops of the second or third decimal dilution, two or three times a day. Less doses, if not inoperative, are less efficacious. Treatment of the diseases of the mucous mnembrane.These diseases, as has already been suggested, are often induced by exposure to cold. When so induced, if the patient be at the time, or has recently been, affected with syphilis, these cases acquire a peculiar character from that circumstance-they become chronic, secrete copiously, and the tonsillary glands may become much enlarged, and deeply ulcerated. These attacks, though of a syphilitic type, have their origin in catarrh, and their early arrest may sometimes be effected by the usual remedies for catarrhal sore-throat, viz., Aconite, Bell., Apis, and liercurius corrosivus. After Aconite has been exhibited to reduce any general febrile excitement, as well as to act on the local disorder, Apis is often very efficacious, in drop Zdoses of the third decimal tincture. If it fail, Bella 90 SECONDARY SYPHILIS. donna, Lachesis, and JAercurius corrosivus may be had recourse to. In cases of inflammation, or ulceration, of the same part, in company with other secondary symptoms-of the skin, for example-if Mercury have not already been administered to excess, the iodide or bin-iodide of that metal, in one grain doses of the second or third decimal, should be administered twice a day. The throat will often get well paripassu with the other symptoms; but should the disease persist when these have vanished, the treatment may be directed against it especially. Acidum nitricun is here a useful remedy, and may be given internally, in five-drop doses of the second decimal tincture, three times a day; and at the same a gargle, composed of half a drachm of the pure acid in six ounces of water, may be employed locally. This, though beneficial in some cases, is far less efficacious than the Argentum nitricum. This may be applied in its solid form when practicable, or in solution, in the proportion of five grains to the ounce of distilled water; the throat should be mopped with this once or twice a day. I employ this medicine in one of these forms in the majority of cases of syphilitic sore throat, and the comfort derived from it is immense. It is beyond dispute that some persons are more susceptible than others to constitutional syphilis. It is equally certain that the scrofulous constitution is that which is most exposed to its attack. That being so, the importance of attending to the general health of the patient, during the course of secondary syphilis, is self SECONDARY SYPHILIS. 91 evident. He should carefully observe all those measures calculated to maintain his health in the finest possible condition. In those early secondary diseases of which we have been speaking-of the skin and throat-being, as they commonly are, inflammatory and febrile, he should indulge in alcoholic drinks very sparingly, or not at all, at least in the earlier stages. He should live on plain, good, nutritious, food. In keeping with this, as well as in reference to the depression of the general powers which commonly characterise constitutional syphilis, cod-liver oil is an agent of first-rate importance. Possessing the advantage of not being medicinal, and therefore not interfering with the action of medicines, I find it in many cases more than a substitute for the renowned Sarsaparilla -a medicine which, when there is no particular indication for other remedies, may be prescribed with the greatest advantage. A small quantity of cod-liver oil is sufficient-a dessert-spoonful, taken every night at bedtime. Larger quantities, taken at other periods of the day, are apt to do more harm than good, by nauseating the patient, and destroying his appetite. If the throat or mouth be affected, he should strictly avoid smoking. He should not overfatigue himself. For skin diseases he should take a warm bath twice a week. He should clothe himself judiciously, and carefully guard against the common causes of cold. The following medicines may, also, be administered with manifest benefit, viz., Acid. Sulphlur., Borax, Lachesis, Phosphorus, Hepar Su1phuris, and Sulphur. 92 TERTIARY SYMPTOMS OF SYPHILIS. Certain products of the syphilitic taint, more inveterate than those we have been considering, differing from them, also, in their nature and situation, and commonly affecting the system at a later period than the secondary symptoms, have been named by iRicord, tertiary symptoms of syphilis. These diseases are said, also, to have lost the property, which the secondary symptoms retain, of infection. They seldom appear earlier than six months after the primary disease, often later still, and there is no certain immunity from them for many years afterwards. Patients have been known to develope them at the end of ten, twenty, or thirty years. Either as local diseases, or in the form of syphilitic cachexia, these symptoms may affect every organ and structure of the body. They are chiefly the following, viz., affections of the bony structure, of the skin and cellular tissue, of the testes, and of the system at large, in the form of syphilitic cachexia. We will devote a few words to each of these, in the above order. AFFECTIONS OF THE OSSEOUS SYSTEM. PERIOSTITIS-OSTITIS-CA-IES-NEccosIs. -Periostitis is the earliest and most common of these affections. GUTMMATA. 93. There may be simple inflammation without perceptible thickening of the membrane; or there may be a deposit of plastic lymph, resulting in the formation of nodes. The long bones of the leg and forearm, and the flat bones of the skull, are most frequently affected. The leading symptoms are, dull aching pains, generally worse at night; great tenderness on pressing the diseased part; and some impediment to free motion. Gradual enlargement, and hardening of the swelling, and its conversion into bony structure, are the changes which result in hard node. In ostitis, the bony structure is inflamed. This is a common consequence of inflammation of the periosteum. It is apt to terminate in the formation of abscess, which, discharging, exposes the denuded bone, and caries or the destruction of portions of the bone, is the result. When this occurs in the skull, if both tables of the bone are destroyed, death may follow from exposure of the membranes of the brain. These severe cases of bone disease seldom occur, except in depraved and broken-down constitutions, and are generally attended with hectic, and general failure of the vital powers. GUTMMATA. This affection consists in the formation of small, hard, painless swellings under the skin of the scalp, neck, extremities, scrotum, and penis, and under the mucous membrane of the tongue. These tumours may either subside, SYPHILITIC SAICOCELE. or remain hard and moveable for a long time, and ultimately suppurate, and discharge, leaving deep, spreading, troublesome ulcers. In the tongue they are sometimes very annoying. The organ becomes hard and knotty, either in one portion, or throughout its whole sufaceits free motions in chewing and speaking being greatly impaired. These lumps may be distinguished from cancer, by the absence of the lancinating pains which characterise that disease, and by the knots being more diffused and superficial; whereas cancer is in one lump, is stony hard, and implicates the whole thickness of the tongue. SYPHILITIC SARCOCELE. This consists in a gradual, and often at first imperceptible, enlargement of one or both testicles. The function of the organs becomes impaired, the semen is altered in quality and quantity, and the venereal appetite diminishes. The enlargement, after having existed a longer or shorter time, may be succeeded by reabsorption of the abnormal deposit, and a gradual wasting, and, in some cases, entire disappearance of the testis. 95 SYPHILITIC CACHEXIA. This is the most direful of all the consequences of syphilis. Here the very fountains of life seem to be poisoned. Every function is deranged; the nervous and physical powers become exhausted; the countenance becomes sallow, and the surface anmemic; the flesh flabby; the body wastes; the limbs become weak and trembling; the appetite fails; and continued nervous fever, night sweats, and hectic, supervene. Conjoined with these symptoms are commonly found disease of the bones; tubercles, ulcers, and inveterate skin eruptions; and death may result from general anaemia, or from some internal organ, previously predisposed to disease, becoming disorganized, such as ulceration of the lungs or intestines. The circumstances which favour the development of this terrible condition, are a scrofulous constitution, improper treatment of syphilis, mercurialization, exposure to cold and damp, intemperance, bad living, and other causes tending to undermine the vital powers. Treatnent of tertiary symp tovmis.--Several modifications of the rules laid down for the treatment of the early secondary symptoms, are here required. The cure, as might be expected from the inveterate nature of these diseases, is both more uncertain and more protracted, than in any of the forms of syphilis we have hitherto mentioned. Palliation and retardation in some cases, 96 SYPHILITIC CACHEXIA. and in others such control over the disease as shall keep it in a state of quiescence, and cause the least possible amount of annoyance to the patient, is the utmost that can be anticipated. A complete and permanent cure is, unhappily, the result in only a small minority of cases.. But, doubtful as the prognosis in any case of this kind must be, I think that homoeopathic medication holds out a much more encouraging prospect of benefit to the patient, than the means commonly adopted in the ordinary system of treatment. This advantage is due to the application of our remedies in accordance with the homceopathic law of similarities; to the greater number of remedies at our command; and to the wider field of action which, as a consequence, is opened up to us. It is not enough, especially in these inveterate and deep-acting tertiary affections, to attempt to grapple with all their phases by Iodide of Potassimn, as is ordinarily done. That is a most useful remedy in many cases, but it is by no means of universal application. On the very day on which this is written, I have seen a case of tertiary disease of the tongue, which, under allopathic treatment, was always aggravated by Iodide of Potassiun. The pliability-or rather the greater adaptability-of hommeopathy, leaves one at no loss for a remedy in such a case. From the very nature of the circumstances, it would be impossible for me, advantageously, to do more than give a bare enumeration of the chief remedies applicable to the different classes of tertiary diseases. Each case, to SYP31LITIC CACHEXTA. 97 be treated with any prospect of success, must be studied by itself, in reference to its particular and appropriate remedy. In simple and uncomplicated diseases, such as the primary venereal affections, the symptoms of which are comparatively few and constant, distinct rules of treatment may be laid down. In affections so deep-seated, so complicated, and involving so many organs and functions, as the secondary and tertiary affections, such a course would be impossible. We can here only indicate, not direct, the treatment. For affections of the periosteum and bones, then, the following remedies are the most useful, viz., Acid. nitric., Aurzim, Calcarea, Kali Hydriodicum, lodium, lifezereum, iJfercurius, Phosphorus, Phosphoric acid, Silicea, Sulphur. In affections of the testes, which often stand alone as indications of syphilitic taint, reference must be had, also, to the state of the constitution generally, and the treatment must be directed accordingly; and as scrofulous degeneration is frequently a leading characteristic, the remedies suitable to that condition would necessarily be referred to. The following have a direct action on the testes, viz., Aurwum, Conium, Clematis, lodium, ljercurius, Pulsatilla, Phosphorus, Sulphur. In syphilitic cachexia, the following are amongst the most appropriate: Arsenicum, Acid. phosphor., Acid. nitricum, Carb. vegetab., China, Kali Hydriodicum, lodium, Mercurius, Sulphur. Here again, as I have done before, when speaking of the primary venereal diseases, I would venture to express 7 98 SYPHILITIC CACHEXIA. a decided preference, based on careful observation, in favour of more than ordinarily potent doses of the medicines. It should never be lost sight of that in syphilis, and especially in its secondary and tertiary forms, we have to deal with a virulent, destructive, and all-pervading poison, which, circulating in and contaminating the blood, attacks the different organs, induces in them structural alterations, interrupts their healthy function, and so tends constantly to undermine the vital powers. To rouse and sustain these powers, to neutralize the depressing effects, if not to antidote the essence, of this poison, I am convinced that, as a rule, the higher potencies of medicines are comparatively useless, and that quantities, larger than the ordinary homoeopathic dose, are essential. I am constantly meeting with cases-with all respect to my professional brethren I say it-both of primary and secondary syphilis, in which the small doses have failed utterly, but which have improved, or got well, under the action of the same, or no better chosen remedies, but which have simply been administered in Jarger doses. Here, also, I would repeat what has already been said with reference to the importance of attending to the general health of patients labouring under the constitutional effects of syphilis. It is not sufficient simply to give an infinitesimal dose of medicine and say, " Be thou clean." Collateral aid must be obtained from every agent calculated to improve and sustain the patient's constitutional powers. These cases are almost always developed SYPHILITIC CACHEXIA. 99 in scrofulous constitutions; or, if not, the diseases themselves have a tendency to depress the vital powers, and induce all those feelings of languor and debility which have already been described. To counteract this, to bring the system up to the finest standard of health, and neutralize the effects of the venereal virus, the patient should be instructed to adopt all those means which are known to impart vigour to a depraved constitution. Foremost amongst these are temperate, yet generous, and nutritious diet, cod-liver oil, friction of the skin, and bathings, different kinds of out-of-door exercise, and especially, when it can be obtained, country, and seaside, air. The effects of syphilis are much less severe in the country than in towns. Above all, the patient should be impressed with the absolute necessity of a steady and prolonged perseverance in the proper course of medical treatment. Nothing but this will bring about ultimate immunity from the ravages of the venereal poison. 104 CASES. 12th.-The ulcer healing favorably. The buboes looking healthy under Calendula dressing. 30th.-Quite well. It is well known that the situation' of the ulcer determines that of the bubo. The latter is always on the same side as the former. In this case, an ulcer on both sides of the fraenum, begat a bubo in both groins. CASE IX.-Soft Chancre, with Phimosis and Bubo. December 18th.- - Five weeks a chancre at the junction of prepuce and glans penis. The foreskin is so firmly contracted that the ulcer cannot be seen. There is a red, inflamed bubo in one groin, which has been coming forward the last week. He has been under treatment, and is told that he has had no Mercury. To take MXer. sol. I, gr. ij, ter die. 24th.-The penis is much better. The foreskin less swollen and tender; no discharge. Open the bubo, and order him to continue the same medicine. January 1st.-The bubo doing well. The penis ditto. 15th.-The bubo healing under water dressing. The foreskin less swollen and contracted. He can with some little difficulty retract it, and the ulcer is found to have healed. From this time he dressed the bubo with Calendula lotion, as it was rather sluggish in healing, and recovered without any untoward symptom. CASE X.-Bubo, after Soft Chancre. December 18th.- - Coition seven weeks since. There was a superficial, ulcer-like excoriation on the outside of prepuce four weeks; never any hardness. He applied Zinc lotion, but took no medicine. There is now a scab firmly attached to the seat of ulcer. Eight days ago, a gland in the right groin became tender and swollen. There is now a bubo nearly ready to open. Take Mer. sol. -, gr. ij, bis die. 106 CASES. latter. The disease progressed under salivation. The Nitric Acid, which antidotes the Mercury, did not arrest the ulcerative process, which still persisted under the second allopathic course of Mercury, and was only arrested, and the cure brought to a successful issue, by the small doses of the black oxide. Other cases of a like kind, that have occurred in my own practice, confirm this view of the case. CASE XII.-Chancre-threatening Bubo-Warts. May 3rd.- -- Six weeks since contracted chancre. Understanding something of medicine, he touched it himself with caustic. Then took one-grain doses of Iodide of Mercury, which purged him. Then rubbed Mercurial ointment into his thighs for a week. Then took five-grain doses of Hydr. c. Cretd three times a day. All this produced no perceptible effect on his system. The ulcer, after a while, nearly closed, but there still remained, at the above date, some hardness, and a tendency to warts, which are springing up near the frmnum. Thinking he had had Mercury enough, I prescribed Acid. Nitric. 5, gtt. x, ter die, and Calend. lotion to part. 21st.-The warts had nearly disappeared, but there was an open ulcer-a fresh one-by the side of the franum preputii; a gland in the groin was enlarged and tender. To have lMer. sol. t, gr. ij, ter die. June 6th.-The greatest amendment followed this treatment. The gland in the groin was well, the warts had disappeared, the ulcer had healed. Continue medicine a little longer. Cured. This case was interesting as showing the good effect of Acid. Nitric. in checking warty growth, and as proving that the previous exhibition of Mercury in large quantities does not always contra-indicate its use in homoeopathic CASES. 107 doses; nor apparently does it interfere with its curative action. CASE XIII.- Simple Sloughing Phigedanic Chancre, Sc. October 12th.- - Impure intercourse ten days since; an ulcer appeared seven days after on the edge of the prepuce, and another at the root of the penis; the former is soft and lardaceous, the latter scabbed over. To have Mere. sol. -, gr. ij, ter die. 15th.-The ulcer on prepuce already looks a little cleaner, and the swelling and inflammation of prepuce less. Mere. sol. i, ter die. 22nd.-The swelling of prepuce gone, the ulcer filling up. The scab at the root of penis hard, but separating from the skin, as if healing underneath. November 19th.-The ulcer all but perfectly healed over. The scab ditto. Continue medicine. From that time, without assignable cause, the place at the base of the penis became unhealthy; it spread rapidly, became foul and sloughy at the bottom; gradually, another and another place became hard, then black, sloughed, and left a deep, foul ulcer, until at length, the whole root of the penis was encircled with these foul ulcers, which threatened to amputate the organ, unless arrested in their progress. Being satisfied that they were of the nature of soft chancre, and having, therefore, no apprehension of secondary symptoms, I at once omitted the Mercurius and gave Acid. Nitric. -, ten drops, every four hours. Nourishing diet and cod-liver oil. The patient to remain quiet and recumbent, and to apply linseed-meal poultices to the ulcers. Under this treatment the destructive process was gradually arrested. The healing process, however, being very tardy, I again resumed the use of Mercurius in the form of iodide,3 gr. ij, night and morning, still continuing the Acid. Nitric. for some time longer in the middle of the day, and ultimately this was changed for Kali hydriodicum. The patient's health improved, (for he had become weak), the ulcers filled up, he resumed his occupation, and has suffered no inconvenience since. 108 CASES. This was an interesting, though exceedingly severe and obstinate, case. I could not account for the sudden accession of unfavorable symptoms, except on the score of intense mental anxiety, which the circumstances of the case unavoidably entailed upon him. CASE XIV.-- ard Chancres, and secondary Erythema, at the same time. July 12th.- - Intercourse two months ago. One ulcer has existed five weeks. There are now two large, deep, foul, ulcers, eating down into the glans penis just by the corona. The prepuce is much swollen, and there is almost strangulating paraphimosis. The bases of the ulcers are very hard. There is scarcely any discharge. He came to me a few days before the above date, complaining of lassitude, headache, loss of appetite, &c., but said nothing about the syphilis. Visiting me on the 12th, his body, from head to foot, was studded, almost as thickly as confluent smallpox, with secondary erythema. I at once saw its nature, and a single question and answer, explained the whole state of the case. The eruption was papular, and many of the spots were scaly. He still complained of the constitutional symptoms which often accompany the outbreak of these eruptions-headache, debility, anorexia, &c. He had also some soreness of the throat and a slight husky cough. He had undergone no treatment whatever for this complaint. I drew the foreskin forward, ordered Lotio nigra to be applied to the ulcers, and gave him MJerc. sol. ~, gr. iij, ter die, to take internally. 18th.-Already amazingly better. The ulcers look clean and healthy, and are granulating. The eruption is fading fast. He is also better in health. Continue the treatment. August 2nd.-The chancres have filled up and healed over. Continue the MeP. sol. 14th.-The rash much less prominent. Some hardness in the seat of the ulcers. He continued treatment for some time longer, taking ultimately the iodide instead of the oxide of Mercury. He got perfectly well, and has had no sign of a relapse. CASES. 109 Let those who question the power of homoeopathic remedies to cure syphilis, explain away this case, one of the most genuine examples of primary and secondary syphilis that could possibly come under a surgeon's notice. CASE XV.-Hard Chancre and Secondary Symptoms. February 10th.- --Ten weeks since contracted what he was told by a medical gentleman whom he consulted in the country was " an excoriation" on the corona glandis. It was then quite soft. Ordered Black wash, but no medicine. The ulcer did not heal. Then, a fortnight from the first, it was burnt with caustic, and twice afterwards, the last time three weeks ago. There was no hardness before the caustic was applied. There is now a large chancre, as hard as a piece of leather, under the foreskin, and yet his medical attendant still persists that it is not syphilitic, and declines giving him any medicine. To take Mfer. sol. , gr. iij, ter die. 15th.-By report, the sore spreading and eating down into the penis. Continue the medicine. It should have been stated that when he visited me on the 10th he had on the forehead and face, and other parts of the body, a great deal of papular eruption, some of the spots being covered with fine scurf. He had suffered some days previously with frontal headache, and a sense of immense weight on the top of it; he had also aching pains in his back. 22nd.-He visited me again, wonderfully better. The spots are much fainter, and the ulcer has filled up and nearly skinned over. Continue medicine. March 20th.-Has continued the treatment for the last few days with the second decimal instead of the first. The ulcer is quite well; some hardness remains. The spots scarcely visible. Jfere. biniodid. j gr. iij, bis die. April 1st.-Apparently well; some faint stains of the skin. Continue treatment, for safety sake, some time longer. 110 CASES. CASE XVI.-Hard Chancre and Secondary Sore Throat. December 18th.- -- t. 45. Has a small, hard chancre on the tip of the penis, involving the whole of the orifice of the urethra. The orifice is red and swollen, and covered with a hard kind of scab; there is no discharge. When grasped between the finger and thumb the part feels like a large pea in size and hardness. Take Mere. sol. 1, gr. ij, ter die. Under this treatment, with no variation, excepting that the second decimal was substituted for the first, the ulcer gradually cleaned, the leathery surface gave place to healthy granulations; the hardness gradually subsided, and on the 18th of January the wound had healed. He continued the medicine for some time longer. The glands in the groin were not enlarged, nor were there any signs of secondary symptoms, until one cold day he incautiously rode outside a cab without sufficient covering, and caught a severe cold, which resulted, two days later, in a sore throat, and much enlargement of the tonsils, which ulcerated at first superficially, and then deeply, and gave a good deal of trouble for three months or more. The tongue also, and the corners of the mouth, became inflamed and cracked. He had Kali hydriodicum 0, gr. ij, his die; Mer. biniodid. -, gr. iij, bis die; 01. Jecoris, and caustic to the throat. The patient persisted, throughout the whole attack, in smoking, which in all cases of sore throat and affections of the tongue and mouth, is a most pernicious habit, and should be scrupulously avoided. CASE XVII.-Hard Preputial and Urethral Chancres-Secondary Symptoms. August 22nd.- ----, t. 24. Had impure intercourse a month since. The last week an ulcer, small, raised, and hard, on the frmnum. To take Mler. sol. 1, ter die, and Calendula lotion to be applied to the part. 28th.-The same. Continue. CASES. 117 no opportunity of ascertaining the result of her accouchement-whether or not the child was infected. CASE XXV.-Secondary Syphilitic Iritis. October 19th.- -, aet. 31. He had contracted chancre some months previously, and was treated allopathically by large doses of Mercury. It had been followed by secondary skin eruptions, and these by iritis, for which he took Bell., Mere., and other remedies prescribed by a colleague, and had Belladonna applied to the brow. The active symptoms were a good deal subdued when he visited me. The iris, however, was still irregular and discoloured, and the sclerotic red and inflamed. There was some hardness and redness remaining on the site of the ulcer on the penis. There was also, enlargement and superficial ulceration of the tonsils. His health was not good. He had been living rather low, and was not of robust constitution. To take Tinct. Arsen. X, gtt. v, ter die, and Cod-liver oil, and drop a solution of sulphate of Atropine into the eye every night. 23rd.-The change for the better was very great. There was scarcely a tinge of redness on the eye remaining. Continue medicine. 28th.-The eye all but well. The throat much better, also. From this time his amendment was uninterrupted. After a month's residence by the seaside he returned home, apparently quite restored. Some months afterwards there was a slight return of constitutional symptoms, but not of the eye disease. CASE XXVI.- Syphilitic Cachexia-Scre Throat-Ulcerated Glands-Nodes-Laryngitis. July 30th.- -, oet. 24. Got into a horrible state of syphilitic disease in a hot climate, a year ago. Took a little Mercury six months ago. The sore healed. He got cold; ulcerated sore throat followed. The glands in the neck swelled, and there are now three open ulcers on the right side of the neck, and some under the chin, LIST OF HOM(EOPATHIC WORKS PUBLISHED AND IMPORTED BY HENRY TURNER & CO., ^Jjrieo ft2i4 Grejii'st5 awO Lebirda Vnblis8jcrs' 77, FLEET STREET, LONDON, E.C.; 41, PICCADILLY, AND 15, MARKET STREET, MANCHESTER. 4** All Books, the published price of which is Is. or upwards, are delivered post free to any address within the limits of the reduced Book Postage. 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