id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303685-sxsrz60h	Guthery, Eugene	Zinc pyrithione in alcohol-based products for skin antisepsis: Persistence of antimicrobial effects	2005-01-29		.txt	text/plain	4492	262	44	Therefore, alcohol-based products must have a preservative agent such as iodine/iodophor compounds, chlorhexidine gluconate, or zinc pyrithione, to extend its antimicrobial effects. This work includes a literature review of current zinc pyrithione applications in drugs and cosmetics, a safety and toxicity evaluation, consideration of the proposed mechanisms of antimicrobial action, in vitro and in vivo efficacy data, and a discussion of the mechanisms that confer the desired antimicrobial persistence. The authors' conclusion is that zinc pyrithione is not only a safe and effective antimicrobial but that its use in certain alcohol-based formulations results in antimicrobial efficacy exceeding that of iodine and chlorhexidine gluconate. Preservative systems in some of the currently marketed alcohol-based products for skin antisepsis include iodine/iodophors compounds, CHG, and zinc pyrithione (ZPT). Therefore, this article includes a brief review of the published literature related to the development, safety, efficacy, and clinical utility of ZPT and evaluating its merits as a preservative for alcohol-based products of skin antisepsis.	./cache/cord-303685-sxsrz60h.txt	./txt/cord-303685-sxsrz60h.txt