id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342523-52t7dh4n	Dibner, Julia J.	Direct COVID-19 Infection of Enterocytes: The Role of Hypochlorhydria	2020-08-11		.txt	text/plain	1301	79	49	The current report describes a need for selective stool testing to explore fecal shedding of viral RNA and presents a hypothesis for direct infection of enterocytes in cases of hypochlorhydria. Clinical and virological aspects of enteric COVID-19 disease have been reviewed, with authors suggesting the need for study of possible fecal-oral transmission (1, 3) . The purposes of this brief report are to emphasize the importance of testing stool samples under certain conditions and to suggest a novel route of direct enterocyte infection by COVID-19 in cases of developmental or acquired hypochlorhydria. Although there is observational evidence that long-term or high-level use of PPI is associated with an increased risk of testing positive for COVID-19 (10), certain histamine-2 receptor antagonists (H2RA) and a PPI have been observed to improve disease outcome in patients already infected with COVID-19 virus (11) .	./cache/cord-342523-52t7dh4n.txt	./txt/cord-342523-52t7dh4n.txt