id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-026421-ygocpnht	de Jager, Pauline	Response to the authors	2020-06-08		.txt	text/plain	701	43	52	High-frequency oscillatory ventilation (HFOV) is used in our unit for any type of PARDS when the patient meets specific criteria as outlined in our manuscript (in summary, peak inspiratory pressure [PIP] > 28-32 cm H 2 O, PEEP > 8 cm H 2 O, FiO 2 > 0.60, and oxygenation index [OI] increases on three consecutive 1-h measurements despite increasing PEEP) [1] . We understand the author's perspective that HFOV might be more effective in certain types of PARDS, but we advocate that HFOV should not only be considered in case of refractory hypoxaemia, but also when the bedside team wants to prevent ventilator settings becoming toxic. For simplicity, when we implemented the HFOV clinical algorithm in our unit, the advice was to start with 12 Hz in all patients, irrespective of age or PARDS severity and titrate immediately after the lung volume optimisation manoeuvre using the PCO 2 to give direction (e.g. frequency up or down). Lung volume optimization maneuver responses in pediatric high frequency oscillatory ventilation	./cache/cord-026421-ygocpnht.txt	./txt/cord-026421-ygocpnht.txt