id sid tid token lemma pos cord-026421-ygocpnht 1 1 key key JJ cord-026421-ygocpnht 1 2 : : : cord-026421-ygocpnht 1 3 cord-026421-ygocpnht cord-026421-ygocpnht NNP cord-026421-ygocpnht 2 1 authors author NNS cord-026421-ygocpnht 2 2 : : : cord-026421-ygocpnht 2 3 de de NNP cord-026421-ygocpnht 2 4 Jager Jager NNP cord-026421-ygocpnht 2 5 , , , cord-026421-ygocpnht 2 6 Pauline Pauline NNP cord-026421-ygocpnht 2 7 ; ; : cord-026421-ygocpnht 2 8 Kneyber Kneyber NNP cord-026421-ygocpnht 2 9 , , , cord-026421-ygocpnht 2 10 Martin Martin NNP cord-026421-ygocpnht 2 11 C. C. NNP cord-026421-ygocpnht 2 12 J. J. NNP cord-026421-ygocpnht 2 13 title title NN cord-026421-ygocpnht 2 14 : : : cord-026421-ygocpnht 2 15 Response response NN cord-026421-ygocpnht 2 16 to to IN cord-026421-ygocpnht 2 17 the the DT cord-026421-ygocpnht 2 18 authors author NNS cord-026421-ygocpnht 2 19 date date NN cord-026421-ygocpnht 2 20 : : : cord-026421-ygocpnht 2 21 2020 2020 CD cord-026421-ygocpnht 2 22 - - HYPH cord-026421-ygocpnht 2 23 06 06 CD cord-026421-ygocpnht 2 24 - - HYPH cord-026421-ygocpnht 2 25 08 08 CD cord-026421-ygocpnht 2 26 journal journal NN cord-026421-ygocpnht 2 27 : : : cord-026421-ygocpnht 3 1 Ann Ann NNP cord-026421-ygocpnht 3 2 Intensive Intensive NNP cord-026421-ygocpnht 3 3 Care Care NNP cord-026421-ygocpnht 3 4 DOI DOI NNP cord-026421-ygocpnht 3 5 : : : cord-026421-ygocpnht 3 6 10.1186 10.1186 CD cord-026421-ygocpnht 3 7 / / SYM cord-026421-ygocpnht 3 8 s13613 s13613 NN cord-026421-ygocpnht 3 9 - - HYPH cord-026421-ygocpnht 3 10 020 020 CD cord-026421-ygocpnht 3 11 - - HYPH cord-026421-ygocpnht 3 12 00694 00694 CD cord-026421-ygocpnht 3 13 - - SYM cord-026421-ygocpnht 3 14 4 4 CD cord-026421-ygocpnht 4 1 sha sha NNP cord-026421-ygocpnht 4 2 : : : cord-026421-ygocpnht 4 3 213a4feb2b54dd0e644e4bb45d8ef7a5cb5ca199 213a4feb2b54dd0e644e4bb45d8ef7a5cb5ca199 CD cord-026421-ygocpnht 4 4 doc_id doc_id CD cord-026421-ygocpnht 4 5 : : : cord-026421-ygocpnht 4 6 26421 26421 CD cord-026421-ygocpnht 4 7 cord_uid cord_uid NNS cord-026421-ygocpnht 4 8 : : : cord-026421-ygocpnht 4 9 ygocpnht ygocpnht NNP cord-026421-ygocpnht 4 10 nan nan NNP cord-026421-ygocpnht 5 1 We -PRON- PRP cord-026421-ygocpnht 5 2 like like VBP cord-026421-ygocpnht 5 3 to to TO cord-026421-ygocpnht 5 4 thank thank VB cord-026421-ygocpnht 5 5 the the DT cord-026421-ygocpnht 5 6 authors author NNS cord-026421-ygocpnht 5 7 for for IN cord-026421-ygocpnht 5 8 their -PRON- PRP$ cord-026421-ygocpnht 5 9 interest interest NN cord-026421-ygocpnht 5 10 in in IN cord-026421-ygocpnht 5 11 our -PRON- PRP$ cord-026421-ygocpnht 5 12 manuscript manuscript NN cord-026421-ygocpnht 5 13 and and CC cord-026421-ygocpnht 5 14 their -PRON- PRP$ cord-026421-ygocpnht 5 15 positive positive JJ cord-026421-ygocpnht 5 16 feedback feedback NN cord-026421-ygocpnht 5 17 . . . cord-026421-ygocpnht 6 1 High high JJ cord-026421-ygocpnht 6 2 - - HYPH cord-026421-ygocpnht 6 3 frequency frequency NN cord-026421-ygocpnht 6 4 oscillatory oscillatory JJ cord-026421-ygocpnht 6 5 ventilation ventilation NN cord-026421-ygocpnht 6 6 ( ( -LRB- cord-026421-ygocpnht 6 7 HFOV HFOV NNP cord-026421-ygocpnht 6 8 ) ) -RRB- cord-026421-ygocpnht 6 9 is be VBZ cord-026421-ygocpnht 6 10 used use VBN cord-026421-ygocpnht 6 11 in in IN cord-026421-ygocpnht 6 12 our -PRON- PRP$ cord-026421-ygocpnht 6 13 unit unit NN cord-026421-ygocpnht 6 14 for for IN cord-026421-ygocpnht 6 15 any any DT cord-026421-ygocpnht 6 16 type type NN cord-026421-ygocpnht 6 17 of of IN cord-026421-ygocpnht 6 18 PARDS PARDS NNP cord-026421-ygocpnht 6 19 when when WRB cord-026421-ygocpnht 6 20 the the DT cord-026421-ygocpnht 6 21 patient patient NN cord-026421-ygocpnht 6 22 meets meet VBZ cord-026421-ygocpnht 6 23 specific specific JJ cord-026421-ygocpnht 6 24 criteria criterion NNS cord-026421-ygocpnht 6 25 as as IN cord-026421-ygocpnht 6 26 outlined outline VBN cord-026421-ygocpnht 6 27 in in IN cord-026421-ygocpnht 6 28 our -PRON- PRP$ cord-026421-ygocpnht 6 29 manuscript manuscript NN cord-026421-ygocpnht 6 30 ( ( -LRB- cord-026421-ygocpnht 6 31 in in IN cord-026421-ygocpnht 6 32 summary summary NN cord-026421-ygocpnht 6 33 , , , cord-026421-ygocpnht 6 34 peak peak JJ cord-026421-ygocpnht 6 35 inspiratory inspiratory JJ cord-026421-ygocpnht 6 36 pressure pressure NN cord-026421-ygocpnht 6 37 [ [ -LRB- cord-026421-ygocpnht 6 38 PIP PIP NNP cord-026421-ygocpnht 6 39 ] ] -RRB- cord-026421-ygocpnht 6 40 > > NFP cord-026421-ygocpnht 6 41 28 28 CD cord-026421-ygocpnht 6 42 - - SYM cord-026421-ygocpnht 6 43 32 32 CD cord-026421-ygocpnht 6 44 cm cm NN cord-026421-ygocpnht 6 45 H h NN cord-026421-ygocpnht 6 46 2 2 CD cord-026421-ygocpnht 6 47 O o NN cord-026421-ygocpnht 6 48 , , , cord-026421-ygocpnht 6 49 PEEP peep NN cord-026421-ygocpnht 6 50 > > XX cord-026421-ygocpnht 7 1 8 8 CD cord-026421-ygocpnht 7 2 cm cm NN cord-026421-ygocpnht 8 1 H h NN cord-026421-ygocpnht 9 1 2 2 LS cord-026421-ygocpnht 9 2 O o NN cord-026421-ygocpnht 9 3 , , , cord-026421-ygocpnht 9 4 FiO fio NN cord-026421-ygocpnht 9 5 2 2 CD cord-026421-ygocpnht 9 6 > > SYM cord-026421-ygocpnht 9 7 0.60 0.60 CD cord-026421-ygocpnht 9 8 , , , cord-026421-ygocpnht 9 9 and and CC cord-026421-ygocpnht 9 10 oxygenation oxygenation NN cord-026421-ygocpnht 9 11 index index NN cord-026421-ygocpnht 9 12 [ [ -LRB- cord-026421-ygocpnht 9 13 OI OI NNP cord-026421-ygocpnht 9 14 ] ] -RRB- cord-026421-ygocpnht 9 15 increases increase VBZ cord-026421-ygocpnht 9 16 on on IN cord-026421-ygocpnht 9 17 three three CD cord-026421-ygocpnht 9 18 consecutive consecutive JJ cord-026421-ygocpnht 9 19 1-h 1-h CD cord-026421-ygocpnht 9 20 measurements measurement NNS cord-026421-ygocpnht 9 21 despite despite IN cord-026421-ygocpnht 9 22 increasing increase VBG cord-026421-ygocpnht 9 23 PEEP peep NN cord-026421-ygocpnht 9 24 ) ) -RRB- cord-026421-ygocpnht 10 1 [ [ -LRB- cord-026421-ygocpnht 10 2 1 1 CD cord-026421-ygocpnht 10 3 ] ] -RRB- cord-026421-ygocpnht 10 4 . . . cord-026421-ygocpnht 11 1 We -PRON- PRP cord-026421-ygocpnht 11 2 understand understand VBP cord-026421-ygocpnht 11 3 the the DT cord-026421-ygocpnht 11 4 author author NN cord-026421-ygocpnht 11 5 's 's POS cord-026421-ygocpnht 11 6 perspective perspective NN cord-026421-ygocpnht 11 7 that that IN cord-026421-ygocpnht 11 8 HFOV HFOV NNP cord-026421-ygocpnht 11 9 might may MD cord-026421-ygocpnht 11 10 be be VB cord-026421-ygocpnht 11 11 more more RBR cord-026421-ygocpnht 11 12 effective effective JJ cord-026421-ygocpnht 11 13 in in IN cord-026421-ygocpnht 11 14 certain certain JJ cord-026421-ygocpnht 11 15 types type NNS cord-026421-ygocpnht 11 16 of of IN cord-026421-ygocpnht 11 17 PARDS PARDS NNP cord-026421-ygocpnht 11 18 , , , cord-026421-ygocpnht 11 19 but but CC cord-026421-ygocpnht 11 20 we -PRON- PRP cord-026421-ygocpnht 11 21 advocate advocate VBP cord-026421-ygocpnht 11 22 that that IN cord-026421-ygocpnht 11 23 HFOV HFOV NNP cord-026421-ygocpnht 11 24 should should MD cord-026421-ygocpnht 11 25 not not RB cord-026421-ygocpnht 11 26 only only RB cord-026421-ygocpnht 11 27 be be VB cord-026421-ygocpnht 11 28 considered consider VBN cord-026421-ygocpnht 11 29 in in IN cord-026421-ygocpnht 11 30 case case NN cord-026421-ygocpnht 11 31 of of IN cord-026421-ygocpnht 11 32 refractory refractory JJ cord-026421-ygocpnht 11 33 hypoxaemia hypoxaemia NN cord-026421-ygocpnht 11 34 , , . cord-026421-ygocpnht 12 1 but but CC cord-026421-ygocpnht 12 2 also also RB cord-026421-ygocpnht 12 3 when when WRB cord-026421-ygocpnht 12 4 the the DT cord-026421-ygocpnht 12 5 bedside bedside NN cord-026421-ygocpnht 12 6 team team NN cord-026421-ygocpnht 12 7 wants want VBZ cord-026421-ygocpnht 12 8 to to TO cord-026421-ygocpnht 12 9 prevent prevent VB cord-026421-ygocpnht 12 10 ventilator ventilator NN cord-026421-ygocpnht 12 11 settings setting NNS cord-026421-ygocpnht 12 12 becoming become VBG cord-026421-ygocpnht 12 13 toxic toxic JJ cord-026421-ygocpnht 12 14 . . . cord-026421-ygocpnht 13 1 An an DT cord-026421-ygocpnht 13 2 individualised individualised JJ cord-026421-ygocpnht 13 3 lung lung NN cord-026421-ygocpnht 13 4 volume volume NN cord-026421-ygocpnht 13 5 optimisation optimisation NN cord-026421-ygocpnht 13 6 manoeuvre manoeuvre NN cord-026421-ygocpnht 13 7 ( ( -LRB- cord-026421-ygocpnht 13 8 such such JJ cord-026421-ygocpnht 13 9 as as IN cord-026421-ygocpnht 13 10 the the DT cord-026421-ygocpnht 13 11 staircase staircase NN cord-026421-ygocpnht 13 12 incremental incremental JJ cord-026421-ygocpnht 13 13 - - HYPH cord-026421-ygocpnht 13 14 decremental decremental JJ cord-026421-ygocpnht 13 15 titration titration NN cord-026421-ygocpnht 13 16 of of IN cord-026421-ygocpnht 13 17 the the DT cord-026421-ygocpnht 13 18 continuous continuous JJ cord-026421-ygocpnht 13 19 distending distend VBG cord-026421-ygocpnht 13 20 pressure pressure NN cord-026421-ygocpnht 13 21 ( ( -LRB- cord-026421-ygocpnht 13 22 CDP CDP NNP cord-026421-ygocpnht 13 23 ) ) -RRB- cord-026421-ygocpnht 13 24 helps help VBZ cord-026421-ygocpnht 13 25 in in IN cord-026421-ygocpnht 13 26 identifying identify VBG cord-026421-ygocpnht 13 27 patients patient NNS cord-026421-ygocpnht 13 28 who who WP cord-026421-ygocpnht 13 29 have have VBP cord-026421-ygocpnht 13 30 potential potential NN cord-026421-ygocpnht 13 31 for for IN cord-026421-ygocpnht 13 32 lung lung NN cord-026421-ygocpnht 13 33 recruitability recruitability NN cord-026421-ygocpnht 13 34 since since IN cord-026421-ygocpnht 13 35 the the DT cord-026421-ygocpnht 13 36 response response NN cord-026421-ygocpnht 13 37 is be VBZ cord-026421-ygocpnht 13 38 highly highly RB cord-026421-ygocpnht 13 39 heterogeneous heterogeneous JJ cord-026421-ygocpnht 13 40 among among IN cord-026421-ygocpnht 13 41 PARDS PARDS NNP cord-026421-ygocpnht 13 42 [ [ -LRB- cord-026421-ygocpnht 13 43 2 2 CD cord-026421-ygocpnht 13 44 ] ] -RRB- cord-026421-ygocpnht 13 45 . . . cord-026421-ygocpnht 14 1 As as IN cord-026421-ygocpnht 14 2 our -PRON- PRP$ cord-026421-ygocpnht 14 3 data datum NNS cord-026421-ygocpnht 14 4 showed show VBD cord-026421-ygocpnht 14 5 , , , cord-026421-ygocpnht 14 6 such such PDT cord-026421-ygocpnht 14 7 an an DT cord-026421-ygocpnht 14 8 individualised individualised JJ cord-026421-ygocpnht 14 9 manoeuvre manoeuvre NN cord-026421-ygocpnht 14 10 can can MD cord-026421-ygocpnht 14 11 be be VB cord-026421-ygocpnht 14 12 tolerated tolerate VBN cord-026421-ygocpnht 14 13 well well RB cord-026421-ygocpnht 14 14 in in IN cord-026421-ygocpnht 14 15 terms term NNS cord-026421-ygocpnht 14 16 of of IN cord-026421-ygocpnht 14 17 haemodynamic haemodynamic JJ cord-026421-ygocpnht 14 18 effects effect NNS cord-026421-ygocpnht 14 19 with with IN cord-026421-ygocpnht 14 20 a a DT cord-026421-ygocpnht 14 21 minimal minimal JJ cord-026421-ygocpnht 14 22 risk risk NN cord-026421-ygocpnht 14 23 of of IN cord-026421-ygocpnht 14 24 barotrauma barotrauma NN cord-026421-ygocpnht 15 1 ( ( -LRB- cord-026421-ygocpnht 15 2 in in IN cord-026421-ygocpnht 15 3 fact fact NN cord-026421-ygocpnht 15 4 , , , cord-026421-ygocpnht 15 5 we -PRON- PRP cord-026421-ygocpnht 15 6 observed observe VBD cord-026421-ygocpnht 15 7 no no DT cord-026421-ygocpnht 15 8 barotraumas barotraumas RBR cord-026421-ygocpnht 15 9 following follow VBG cord-026421-ygocpnht 15 10 the the DT cord-026421-ygocpnht 15 11 manoeuvre manoeuvre NN cord-026421-ygocpnht 15 12 in in IN cord-026421-ygocpnht 15 13 our -PRON- PRP$ cord-026421-ygocpnht 15 14 cohort cohort NN cord-026421-ygocpnht 15 15 ) ) -RRB- cord-026421-ygocpnht 15 16 . . . cord-026421-ygocpnht 16 1 The the DT cord-026421-ygocpnht 16 2 authors author NNS cord-026421-ygocpnht 16 3 raise raise VBP cord-026421-ygocpnht 16 4 an an DT cord-026421-ygocpnht 16 5 important important JJ cord-026421-ygocpnht 16 6 point point NN cord-026421-ygocpnht 16 7 : : : cord-026421-ygocpnht 16 8 what what WP cord-026421-ygocpnht 16 9 is be VBZ cord-026421-ygocpnht 16 10 the the DT cord-026421-ygocpnht 16 11 " " `` cord-026421-ygocpnht 16 12 optimal optimal JJ cord-026421-ygocpnht 16 13 " " '' cord-026421-ygocpnht 16 14 frequency frequency NN cord-026421-ygocpnht 16 15 in in IN cord-026421-ygocpnht 16 16 relation relation NN cord-026421-ygocpnht 16 17 to to IN cord-026421-ygocpnht 16 18 PARDS PARDS NNP cord-026421-ygocpnht 16 19 severity severity NN cord-026421-ygocpnht 16 20 ? ? . cord-026421-ygocpnht 17 1 Although although IN cord-026421-ygocpnht 17 2 the the DT cord-026421-ygocpnht 17 3 concept concept NN cord-026421-ygocpnht 17 4 of of IN cord-026421-ygocpnht 17 5 the the DT cord-026421-ygocpnht 17 6 corner corner NN cord-026421-ygocpnht 17 7 frequency frequency NN cord-026421-ygocpnht 17 8 is be VBZ cord-026421-ygocpnht 17 9 quite quite RB cord-026421-ygocpnht 17 10 clear clear JJ cord-026421-ygocpnht 17 11 , , , cord-026421-ygocpnht 17 12 it -PRON- PRP cord-026421-ygocpnht 17 13 is be VBZ cord-026421-ygocpnht 17 14 difficult difficult JJ cord-026421-ygocpnht 17 15 to to TO cord-026421-ygocpnht 17 16 detect detect VB cord-026421-ygocpnht 17 17 at at IN cord-026421-ygocpnht 17 18 the the DT cord-026421-ygocpnht 17 19 bedside bedside NN cord-026421-ygocpnht 17 20 how how WRB cord-026421-ygocpnht 17 21 the the DT cord-026421-ygocpnht 17 22 " " `` cord-026421-ygocpnht 17 23 optimal optimal JJ cord-026421-ygocpnht 17 24 " " '' cord-026421-ygocpnht 17 25 frequency frequency NN cord-026421-ygocpnht 17 26 can can MD cord-026421-ygocpnht 17 27 be be VB cord-026421-ygocpnht 17 28 identified identify VBN cord-026421-ygocpnht 17 29 in in IN cord-026421-ygocpnht 17 30 heterogenous heterogenous JJ cord-026421-ygocpnht 17 31 PARDS PARDS NNP cord-026421-ygocpnht 17 32 [ [ -LRB- cord-026421-ygocpnht 17 33 3 3 CD cord-026421-ygocpnht 17 34 ] ] -RRB- cord-026421-ygocpnht 17 35 . . . cord-026421-ygocpnht 18 1 Basically basically RB cord-026421-ygocpnht 18 2 , , , cord-026421-ygocpnht 18 3 the the DT cord-026421-ygocpnht 18 4 lower low JJR cord-026421-ygocpnht 18 5 the the DT cord-026421-ygocpnht 18 6 lung lung NN cord-026421-ygocpnht 18 7 compliance compliance NN cord-026421-ygocpnht 18 8 , , , cord-026421-ygocpnht 18 9 the the DT cord-026421-ygocpnht 18 10 higher high JJR cord-026421-ygocpnht 18 11 the the DT cord-026421-ygocpnht 18 12 frequency frequency NN cord-026421-ygocpnht 18 13 probably probably RB cord-026421-ygocpnht 18 14 should should MD cord-026421-ygocpnht 18 15 be be VB cord-026421-ygocpnht 18 16 . . . cord-026421-ygocpnht 19 1 For for IN cord-026421-ygocpnht 19 2 simplicity simplicity NN cord-026421-ygocpnht 19 3 , , , cord-026421-ygocpnht 19 4 when when WRB cord-026421-ygocpnht 19 5 we -PRON- PRP cord-026421-ygocpnht 19 6 implemented implement VBD cord-026421-ygocpnht 19 7 the the DT cord-026421-ygocpnht 19 8 HFOV HFOV NNP cord-026421-ygocpnht 19 9 clinical clinical JJ cord-026421-ygocpnht 19 10 algorithm algorithm NN cord-026421-ygocpnht 19 11 in in IN cord-026421-ygocpnht 19 12 our -PRON- PRP$ cord-026421-ygocpnht 19 13 unit unit NN cord-026421-ygocpnht 19 14 , , , cord-026421-ygocpnht 19 15 the the DT cord-026421-ygocpnht 19 16 advice advice NN cord-026421-ygocpnht 19 17 was be VBD cord-026421-ygocpnht 19 18 to to TO cord-026421-ygocpnht 19 19 start start VB cord-026421-ygocpnht 19 20 with with IN cord-026421-ygocpnht 19 21 12 12 CD cord-026421-ygocpnht 19 22 Hz Hz NNS cord-026421-ygocpnht 19 23 in in IN cord-026421-ygocpnht 19 24 all all DT cord-026421-ygocpnht 19 25 patients patient NNS cord-026421-ygocpnht 19 26 , , , cord-026421-ygocpnht 19 27 irrespective irrespective RB cord-026421-ygocpnht 19 28 of of IN cord-026421-ygocpnht 19 29 age age NN cord-026421-ygocpnht 19 30 or or CC cord-026421-ygocpnht 19 31 PARDS PARDS NNP cord-026421-ygocpnht 19 32 severity severity NN cord-026421-ygocpnht 19 33 and and CC cord-026421-ygocpnht 19 34 titrate titrate VB cord-026421-ygocpnht 19 35 immediately immediately RB cord-026421-ygocpnht 19 36 after after IN cord-026421-ygocpnht 19 37 the the DT cord-026421-ygocpnht 19 38 lung lung NN cord-026421-ygocpnht 19 39 volume volume NN cord-026421-ygocpnht 19 40 optimisation optimisation NN cord-026421-ygocpnht 19 41 manoeuvre manoeuvre NN cord-026421-ygocpnht 19 42 using use VBG cord-026421-ygocpnht 19 43 the the DT cord-026421-ygocpnht 19 44 PCO PCO NNP cord-026421-ygocpnht 19 45 2 2 CD cord-026421-ygocpnht 19 46 to to TO cord-026421-ygocpnht 19 47 give give VB cord-026421-ygocpnht 19 48 direction direction NN cord-026421-ygocpnht 19 49 ( ( -LRB- cord-026421-ygocpnht 19 50 e.g. e.g. RB cord-026421-ygocpnht 19 51 frequency frequency NN cord-026421-ygocpnht 19 52 up up IN cord-026421-ygocpnht 19 53 or or CC cord-026421-ygocpnht 19 54 down down RB cord-026421-ygocpnht 19 55 ) ) -RRB- cord-026421-ygocpnht 19 56 . . . cord-026421-ygocpnht 20 1 Our -PRON- PRP$ cord-026421-ygocpnht 20 2 data datum NNS cord-026421-ygocpnht 20 3 confirmed confirm VBD cord-026421-ygocpnht 20 4 that that IN cord-026421-ygocpnht 20 5 it -PRON- PRP cord-026421-ygocpnht 20 6 was be VBD cord-026421-ygocpnht 20 7 possible possible JJ cord-026421-ygocpnht 20 8 to to TO cord-026421-ygocpnht 20 9 do do VB cord-026421-ygocpnht 20 10 this this DT cord-026421-ygocpnht 20 11 in in IN cord-026421-ygocpnht 20 12 all all DT cord-026421-ygocpnht 20 13 patients patient NNS cord-026421-ygocpnht 20 14 , , , cord-026421-ygocpnht 20 15 irrespective irrespective RB cord-026421-ygocpnht 20 16 of of IN cord-026421-ygocpnht 20 17 age age NN cord-026421-ygocpnht 21 1 ( ( -LRB- cord-026421-ygocpnht 21 2 Fig Fig NNP cord-026421-ygocpnht 21 3 . . NNP cord-026421-ygocpnht 21 4 1 1 CD cord-026421-ygocpnht 21 5 ) ) -RRB- cord-026421-ygocpnht 21 6 . . . cord-026421-ygocpnht 22 1 We -PRON- PRP cord-026421-ygocpnht 22 2 agree agree VBP cord-026421-ygocpnht 22 3 that that IN cord-026421-ygocpnht 22 4 in in IN cord-026421-ygocpnht 22 5 a a DT cord-026421-ygocpnht 22 6 subgroup subgroup NN cord-026421-ygocpnht 22 7 of of IN cord-026421-ygocpnht 22 8 patients patient NNS cord-026421-ygocpnht 22 9 in in IN cord-026421-ygocpnht 22 10 our -PRON- PRP$ cord-026421-ygocpnht 22 11 cohort cohort NN cord-026421-ygocpnht 22 12 , , , cord-026421-ygocpnht 22 13 especially especially RB cord-026421-ygocpnht 22 14 those those DT cord-026421-ygocpnht 22 15 with with IN cord-026421-ygocpnht 22 16 mild mild NN cord-026421-ygocpnht 22 17 - - HYPH cord-026421-ygocpnht 22 18 to to IN cord-026421-ygocpnht 22 19 - - HYPH cord-026421-ygocpnht 22 20 moderate moderate JJ cord-026421-ygocpnht 22 21 PARDS PARDS NNP cord-026421-ygocpnht 22 22 optimisation optimisation NN cord-026421-ygocpnht 22 23 of of IN cord-026421-ygocpnht 22 24 conventional conventional JJ cord-026421-ygocpnht 22 25 mechanical mechanical JJ cord-026421-ygocpnht 22 26 ventilation ventilation NN cord-026421-ygocpnht 22 27 settings setting NNS cord-026421-ygocpnht 22 28 might may MD cord-026421-ygocpnht 22 29 have have VB cord-026421-ygocpnht 22 30 been be VBN cord-026421-ygocpnht 22 31 attempted attempt VBN cord-026421-ygocpnht 22 32 . . . cord-026421-ygocpnht 23 1 The the DT cord-026421-ygocpnht 23 2 median median JJ cord-026421-ygocpnht 23 3 OI OI NNP cord-026421-ygocpnht 23 4 of of IN cord-026421-ygocpnht 23 5 38 38 CD cord-026421-ygocpnht 23 6 as as IN cord-026421-ygocpnht 23 7 pointed point VBN cord-026421-ygocpnht 23 8 out out RP cord-026421-ygocpnht 23 9 by by IN cord-026421-ygocpnht 23 10 the the DT cord-026421-ygocpnht 23 11 reviewer reviewer NN cord-026421-ygocpnht 23 12 is be VBZ cord-026421-ygocpnht 23 13 the the DT cord-026421-ygocpnht 23 14 OI OI NNP cord-026421-ygocpnht 23 15 after after IN cord-026421-ygocpnht 23 16 the the DT cord-026421-ygocpnht 23 17 lung lung NN cord-026421-ygocpnht 23 18 volume volume NN cord-026421-ygocpnht 23 19 optimisation optimisation NN cord-026421-ygocpnht 23 20 manoeuvre manoeuvre NN cord-026421-ygocpnht 23 21 , , , cord-026421-ygocpnht 23 22 hence hence RB cord-026421-ygocpnht 23 23 the the DT cord-026421-ygocpnht 23 24 high high JJ cord-026421-ygocpnht 23 25 CDP CDP NNP cord-026421-ygocpnht 23 26 we -PRON- PRP cord-026421-ygocpnht 23 27 use use VBP cord-026421-ygocpnht 23 28 as as IN cord-026421-ygocpnht 23 29 part part NN cord-026421-ygocpnht 23 30 of of IN cord-026421-ygocpnht 23 31 the the DT cord-026421-ygocpnht 23 32 open open JJ cord-026421-ygocpnht 23 33 - - HYPH cord-026421-ygocpnht 23 34 lung lung NN cord-026421-ygocpnht 23 35 concept concept NN cord-026421-ygocpnht 23 36 confounds confound VBZ cord-026421-ygocpnht 23 37 the the DT cord-026421-ygocpnht 23 38 OI OI NNP cord-026421-ygocpnht 23 39 . . . cord-026421-ygocpnht 24 1 It -PRON- PRP cord-026421-ygocpnht 24 2 is be VBZ cord-026421-ygocpnht 24 3 true true JJ cord-026421-ygocpnht 24 4 that that IN cord-026421-ygocpnht 24 5 in in IN cord-026421-ygocpnht 24 6 general general JJ cord-026421-ygocpnht 24 7 in in IN cord-026421-ygocpnht 24 8 the the DT cord-026421-ygocpnht 24 9 paediatric paediatric JJ cord-026421-ygocpnht 24 10 intensive intensive JJ cord-026421-ygocpnht 24 11 care care NN cord-026421-ygocpnht 24 12 unit unit NN cord-026421-ygocpnht 24 13 there there EX cord-026421-ygocpnht 24 14 is be VBZ cord-026421-ygocpnht 24 15 a a DT cord-026421-ygocpnht 24 16 relatively relatively RB cord-026421-ygocpnht 24 17 low low JJ cord-026421-ygocpnht 24 18 use use NN cord-026421-ygocpnht 24 19 of of IN cord-026421-ygocpnht 24 20 positive positive JJ cord-026421-ygocpnht 24 21 end end NN cord-026421-ygocpnht 24 22 - - HYPH cord-026421-ygocpnht 24 23 expiratory expiratory NN cord-026421-ygocpnht 24 24 pressure pressure NN cord-026421-ygocpnht 24 25 ( ( -LRB- cord-026421-ygocpnht 24 26 PEEP peep NN cord-026421-ygocpnht 24 27 ) ) -RRB- cord-026421-ygocpnht 24 28 and and CC cord-026421-ygocpnht 24 29 tolerance tolerance NN cord-026421-ygocpnht 24 30 of of IN cord-026421-ygocpnht 24 31 high high JJ cord-026421-ygocpnht 24 32 FiO FiO NNS cord-026421-ygocpnht 24 33 2 2 CD cord-026421-ygocpnht 24 34 instead instead RB cord-026421-ygocpnht 24 35 . . . cord-026421-ygocpnht 25 1 However however RB cord-026421-ygocpnht 25 2 , , , cord-026421-ygocpnht 25 3 the the DT cord-026421-ygocpnht 25 4 best good JJS cord-026421-ygocpnht 25 5 strategy strategy NN cord-026421-ygocpnht 25 6 to to TO cord-026421-ygocpnht 25 7 optimise optimise VB cord-026421-ygocpnht 25 8 CMV CMV NNP cord-026421-ygocpnht 25 9 in in IN cord-026421-ygocpnht 25 10 children child NNS cord-026421-ygocpnht 25 11 with with IN cord-026421-ygocpnht 25 12 severe severe JJ cord-026421-ygocpnht 25 13 PARDS PARDS NNP cord-026421-ygocpnht 25 14 remains remain VBZ cord-026421-ygocpnht 25 15 uncertain uncertain JJ cord-026421-ygocpnht 25 16 [ [ -LRB- cord-026421-ygocpnht 25 17 4 4 CD cord-026421-ygocpnht 25 18 ] ] -RRB- cord-026421-ygocpnht 25 19 . . . cord-026421-ygocpnht 26 1 To to IN cord-026421-ygocpnht 26 2 date date NN cord-026421-ygocpnht 26 3 , , , cord-026421-ygocpnht 26 4 there there EX cord-026421-ygocpnht 26 5 is be VBZ cord-026421-ygocpnht 26 6 no no DT cord-026421-ygocpnht 26 7 specific specific JJ cord-026421-ygocpnht 26 8 PEEP peep NN cord-026421-ygocpnht 26 9 strategy strategy NN cord-026421-ygocpnht 26 10 shown show VBN cord-026421-ygocpnht 26 11 to to TO cord-026421-ygocpnht 26 12 be be VB cord-026421-ygocpnht 26 13 beneficial beneficial JJ cord-026421-ygocpnht 26 14 nor nor CC cord-026421-ygocpnht 26 15 are be VBP cord-026421-ygocpnht 26 16 there there EX cord-026421-ygocpnht 26 17 outcome outcome NN cord-026421-ygocpnht 26 18 data datum NNS cord-026421-ygocpnht 26 19 demonstrating demonstrate VBG cord-026421-ygocpnht 26 20 that that IN cord-026421-ygocpnht 26 21 higher high JJR cord-026421-ygocpnht 26 22 PEEP peep NN cord-026421-ygocpnht 26 23 is be VBZ cord-026421-ygocpnht 26 24 better well JJR cord-026421-ygocpnht 26 25 than than IN cord-026421-ygocpnht 26 26 lower low JJR cord-026421-ygocpnht 26 27 PEEP peep NN cord-026421-ygocpnht 26 28 in in IN cord-026421-ygocpnht 26 29 PARDS PARDS NNP cord-026421-ygocpnht 26 30 , , , cord-026421-ygocpnht 26 31 although although IN cord-026421-ygocpnht 26 32 there there EX cord-026421-ygocpnht 26 33 are be VBP cord-026421-ygocpnht 26 34 some some DT cord-026421-ygocpnht 26 35 suggestions suggestion NNS cord-026421-ygocpnht 26 36 that that WDT cord-026421-ygocpnht 26 37 lower low JJR cord-026421-ygocpnht 26 38 PEEP peep NN cord-026421-ygocpnht 26 39 in in IN cord-026421-ygocpnht 26 40 PARDS PARDS NNP cord-026421-ygocpnht 26 41 may may MD cord-026421-ygocpnht 26 42 be be VB cord-026421-ygocpnht 26 43 associated associate VBN cord-026421-ygocpnht 26 44 with with IN cord-026421-ygocpnht 26 45 increased increase VBN cord-026421-ygocpnht 26 46 mortality mortality NN cord-026421-ygocpnht 26 47 [ [ -LRB- cord-026421-ygocpnht 26 48 5 5 CD cord-026421-ygocpnht 26 49 ] ] -RRB- cord-026421-ygocpnht 26 50 . . . cord-026421-ygocpnht 27 1 We -PRON- PRP cord-026421-ygocpnht 27 2 also also RB cord-026421-ygocpnht 27 3 do do VBP cord-026421-ygocpnht 27 4 not not RB cord-026421-ygocpnht 27 5 know know VB cord-026421-ygocpnht 27 6 what what WP cord-026421-ygocpnht 27 7 the the DT cord-026421-ygocpnht 27 8 optimal optimal JJ cord-026421-ygocpnht 28 1 Vt Vt NNP cord-026421-ygocpnht 28 2 is be VBZ cord-026421-ygocpnht 28 3 in in IN cord-026421-ygocpnht 28 4 ( ( -LRB- cord-026421-ygocpnht 28 5 severe severe JJ cord-026421-ygocpnht 28 6 ) ) -RRB- cord-026421-ygocpnht 28 7 PARDS PARDS NNP cord-026421-ygocpnht 28 8 [ [ -LRB- cord-026421-ygocpnht 28 9 6 6 CD cord-026421-ygocpnht 28 10 ] ] -RRB- cord-026421-ygocpnht 28 11 . . . cord-026421-ygocpnht 29 1 Hence hence RB cord-026421-ygocpnht 29 2 , , , cord-026421-ygocpnht 29 3 we -PRON- PRP cord-026421-ygocpnht 29 4 advocate advocate VBP cord-026421-ygocpnht 29 5 that that IN cord-026421-ygocpnht 29 6 HFOV HFOV NNP cord-026421-ygocpnht 29 7 should should MD cord-026421-ygocpnht 29 8 also also RB cord-026421-ygocpnht 29 9 be be VB cord-026421-ygocpnht 29 10 considered consider VBN cord-026421-ygocpnht 29 11 if if IN cord-026421-ygocpnht 29 12 the the DT cord-026421-ygocpnht 29 13 bedside bedside NN cord-026421-ygocpnht 29 14 team team NN cord-026421-ygocpnht 29 15 wants want VBZ cord-026421-ygocpnht 29 16 to to TO cord-026421-ygocpnht 29 17 prevent prevent VB cord-026421-ygocpnht 29 18 ventilator ventilator NN cord-026421-ygocpnht 29 19 settings setting NNS cord-026421-ygocpnht 29 20 becoming become VBG cord-026421-ygocpnht 29 21 toxic toxic JJ cord-026421-ygocpnht 29 22 . . . cord-026421-ygocpnht 30 1 We -PRON- PRP cord-026421-ygocpnht 30 2 eagerly eagerly RB cord-026421-ygocpnht 30 3 await await VBP cord-026421-ygocpnht 30 4 the the DT cord-026421-ygocpnht 30 5 results result NNS cord-026421-ygocpnht 30 6 of of IN cord-026421-ygocpnht 30 7 a a DT cord-026421-ygocpnht 30 8 2-by-2 2-by-2 CD cord-026421-ygocpnht 30 9 factorial factorial NN cord-026421-ygocpnht 30 10 randomised randomised JJ cord-026421-ygocpnht 30 11 controlled control VBN cord-026421-ygocpnht 30 12 trial trial NN cord-026421-ygocpnht 30 13 comparing compare VBG cord-026421-ygocpnht 30 14 the the DT cord-026421-ygocpnht 30 15 effects effect NNS cord-026421-ygocpnht 30 16 of of IN cord-026421-ygocpnht 30 17 ventilation ventilation NN cord-026421-ygocpnht 30 18 strategy strategy NN cord-026421-ygocpnht 30 19 ( ( -LRB- cord-026421-ygocpnht 30 20 CMV CMV NNP cord-026421-ygocpnht 30 21 vs vs IN cord-026421-ygocpnht 30 22 HFOV HFOV NNP cord-026421-ygocpnht 30 23 ) ) -RRB- cord-026421-ygocpnht 30 24 with with IN cord-026421-ygocpnht 30 25 or or CC cord-026421-ygocpnht 30 26 without without IN cord-026421-ygocpnht 30 27 prone prone JJ cord-026421-ygocpnht 30 28 positioning positioning NN cord-026421-ygocpnht 30 29 ( ( -LRB- cord-026421-ygocpnht 30 30 http://www.prosp http://www.prosp NNP cord-026421-ygocpnht 30 31 ect ect NN cord-026421-ygocpnht 30 32 - - , cord-026421-ygocpnht 30 33 netwo netwo JJ cord-026421-ygocpnht 30 34 rk.org rk.org NNP cord-026421-ygocpnht 30 35 ) ) -RRB- cord-026421-ygocpnht 30 36 on on IN cord-026421-ygocpnht 30 37 patient patient JJ cord-026421-ygocpnht 30 38 outcome outcome NN cord-026421-ygocpnht 30 39 [ [ -LRB- cord-026421-ygocpnht 30 40 7 7 CD cord-026421-ygocpnht 30 41 ] ] -RRB- cord-026421-ygocpnht 30 42 . . . cord-026421-ygocpnht 30 43 _SP cord-026421-ygocpnht 31 1 Feasibility feasibility NN cord-026421-ygocpnht 31 2 of of IN cord-026421-ygocpnht 31 3 an an DT cord-026421-ygocpnht 31 4 alternative alternative JJ cord-026421-ygocpnht 31 5 , , , cord-026421-ygocpnht 31 6 physiologic physiologic JJ cord-026421-ygocpnht 31 7 , , , cord-026421-ygocpnht 31 8 individualized individualized JJ cord-026421-ygocpnht 31 9 openlung openlung NN cord-026421-ygocpnht 31 10 approach approach NN cord-026421-ygocpnht 31 11 to to IN cord-026421-ygocpnht 31 12 high high JJ cord-026421-ygocpnht 31 13 - - HYPH cord-026421-ygocpnht 31 14 frequency frequency NN cord-026421-ygocpnht 31 15 oscillatory oscillatory JJ cord-026421-ygocpnht 31 16 ventilation ventilation NN cord-026421-ygocpnht 31 17 in in IN cord-026421-ygocpnht 31 18 children child NNS cord-026421-ygocpnht 31 19 Lung Lung NNP cord-026421-ygocpnht 31 20 volume volume NN cord-026421-ygocpnht 31 21 optimization optimization NN cord-026421-ygocpnht 31 22 maneuver maneuver NN cord-026421-ygocpnht 31 23 responses response NNS cord-026421-ygocpnht 31 24 in in IN cord-026421-ygocpnht 31 25 pediatric pediatric JJ cord-026421-ygocpnht 31 26 high high JJ cord-026421-ygocpnht 31 27 frequency frequency NN cord-026421-ygocpnht 31 28 oscillatory oscillatory JJ cord-026421-ygocpnht 31 29 ventilation ventilation NN cord-026421-ygocpnht 31 30 Understanding understand VBG cord-026421-ygocpnht 31 31 the the DT cord-026421-ygocpnht 31 32 pressure pressure NN cord-026421-ygocpnht 31 33 cost cost NN cord-026421-ygocpnht 31 34 of of IN cord-026421-ygocpnht 31 35 ventilation ventilation NN cord-026421-ygocpnht 31 36 : : : cord-026421-ygocpnht 31 37 why why WRB cord-026421-ygocpnht 31 38 does do VBZ cord-026421-ygocpnht 31 39 high high JJ cord-026421-ygocpnht 31 40 - - HYPH cord-026421-ygocpnht 31 41 frequency frequency NN cord-026421-ygocpnht 31 42 ventilation ventilation NN cord-026421-ygocpnht 31 43 work work NN cord-026421-ygocpnht 31 44 ? ? . cord-026421-ygocpnht 32 1 Recommendations recommendation NNS cord-026421-ygocpnht 32 2 for for IN cord-026421-ygocpnht 32 3 mechanical mechanical JJ cord-026421-ygocpnht 32 4 ventilation ventilation NN cord-026421-ygocpnht 32 5 of of IN cord-026421-ygocpnht 32 6 critically critically RB cord-026421-ygocpnht 32 7 ill ill JJ cord-026421-ygocpnht 32 8 children child NNS cord-026421-ygocpnht 32 9 from from IN cord-026421-ygocpnht 32 10 the the DT cord-026421-ygocpnht 32 11 Paediatric Paediatric NNP cord-026421-ygocpnht 32 12 Mechanical Mechanical NNP cord-026421-ygocpnht 32 13 Ventilation Ventilation NNP cord-026421-ygocpnht 32 14 Consensus Consensus NNP cord-026421-ygocpnht 32 15 Conference Conference NNP cord-026421-ygocpnht 32 16 ( ( -LRB- cord-026421-ygocpnht 32 17 PEMVECC PEMVECC NNP cord-026421-ygocpnht 32 18 ) ) -RRB- cord-026421-ygocpnht 33 1 PEEP peep RB cord-026421-ygocpnht 33 2 lower lower RBR cord-026421-ygocpnht 33 3 than than IN cord-026421-ygocpnht 33 4 the the DT cord-026421-ygocpnht 33 5 ARDS ARDS NNP cord-026421-ygocpnht 33 6 network network NN cord-026421-ygocpnht 33 7 protocol protocol NN cord-026421-ygocpnht 33 8 is be VBZ cord-026421-ygocpnht 33 9 associated associate VBN cord-026421-ygocpnht 33 10 with with IN cord-026421-ygocpnht 33 11 higher high JJR cord-026421-ygocpnht 33 12 pediatric pediatric JJ cord-026421-ygocpnht 33 13 ARDS ARDS NNP cord-026421-ygocpnht 33 14 mortality mortality NN cord-026421-ygocpnht 33 15 Tidal tidal JJ cord-026421-ygocpnht 33 16 volume volume NN cord-026421-ygocpnht 33 17 and and CC cord-026421-ygocpnht 33 18 mortality mortality NN cord-026421-ygocpnht 33 19 in in IN cord-026421-ygocpnht 33 20 mechanically mechanically RB cord-026421-ygocpnht 33 21 ventilated ventilate VBN cord-026421-ygocpnht 33 22 children child NNS cord-026421-ygocpnht 33 23 : : : cord-026421-ygocpnht 33 24 a a DT cord-026421-ygocpnht 33 25 systematic systematic JJ cord-026421-ygocpnht 33 26 review review NN cord-026421-ygocpnht 33 27 and and CC cord-026421-ygocpnht 33 28 meta meta NNP cord-026421-ygocpnht 33 29 - - HYPH cord-026421-ygocpnht 33 30 analysis analysis NN cord-026421-ygocpnht 33 31 of of IN cord-026421-ygocpnht 33 32 observational observational JJ cord-026421-ygocpnht 33 33 studies study NNS cord-026421-ygocpnht 34 1 * * NFP cord-026421-ygocpnht 34 2 High high JJ cord-026421-ygocpnht 34 3 - - HYPH cord-026421-ygocpnht 34 4 frequency frequency NN cord-026421-ygocpnht 34 5 oscillatory oscillatory JJ cord-026421-ygocpnht 34 6 ventilation ventilation NN cord-026421-ygocpnht 34 7 for for IN cord-026421-ygocpnht 34 8 PARDS PARDS NNP cord-026421-ygocpnht 34 9 : : : cord-026421-ygocpnht 34 10 awaiting await VBG cord-026421-ygocpnht 34 11 PROSPect prospect NN cord-026421-ygocpnht 34 12 Not not RB cord-026421-ygocpnht 34 13 applicable applicable JJ cord-026421-ygocpnht 34 14 . . . cord-026421-ygocpnht 35 1 Authors author NNS cord-026421-ygocpnht 35 2 ' ' POS cord-026421-ygocpnht 35 3 contributions contribution NNS cord-026421-ygocpnht 35 4 MK MK NNP cord-026421-ygocpnht 35 5 drafted draft VBD cord-026421-ygocpnht 35 6 the the DT cord-026421-ygocpnht 35 7 manuscript manuscript NN cord-026421-ygocpnht 35 8 . . . cord-026421-ygocpnht 36 1 PdJ PdJ NNP cord-026421-ygocpnht 36 2 contributed contribute VBD cord-026421-ygocpnht 36 3 to to IN cord-026421-ygocpnht 36 4 the the DT cord-026421-ygocpnht 36 5 intellectual intellectual JJ cord-026421-ygocpnht 36 6 content content NN cord-026421-ygocpnht 36 7 of of IN cord-026421-ygocpnht 36 8 the the DT cord-026421-ygocpnht 36 9 manuscript manuscript NN cord-026421-ygocpnht 36 10 . . . cord-026421-ygocpnht 37 1 Both both DT cord-026421-ygocpnht 37 2 authors author NNS cord-026421-ygocpnht 37 3 read read VBP cord-026421-ygocpnht 37 4 and and CC cord-026421-ygocpnht 37 5 approved approve VBD cord-026421-ygocpnht 37 6 the the DT cord-026421-ygocpnht 37 7 final final JJ cord-026421-ygocpnht 37 8 manuscript manuscript NN cord-026421-ygocpnht 37 9 . . . cord-026421-ygocpnht 38 1 None none NN cord-026421-ygocpnht 38 2 . . .