id author title date pages extension mime words sentences flesch summary cache txt cord-004690-q38ogrem Barthold, S. W. Viremic dissemination of mouse hepatitis virus-JHM following intranasal inoculation of mice 1992 .txt text/plain 3308 154 50 Using a sensitive infant mouse bioassay to detect infectious virus, the pattern of mouse hepatitis virus (MHV) JHM dissemination in blood and other tissues was examined during the first 5 days following intranasal inoculation. Previous studies have shown that both of these mouse strains develop disseminated infections between days 3 and 5 after i.n. inoculation, but virus titers and disease are significantly greater in BALB mice compared to SJL mice [5] . The association of interferon-a/~ with viremia was explored initially by analyzing pooled samples of nasal turbinate, blood, liver, brain, or spleen obtained from 3 mice of each genotype on days 0 (controls), 1, 2, 3, and 4 after i.n. inoculation. In the current study, interferon was found in spleen and serum of MHV-JHM-infected BALB mice, but not nose, liver or brain and was not detectable in any tissue of SJL mice. ./cache/cord-004690-q38ogrem.txt ./txt/cord-004690-q38ogrem.txt