id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-004825-cdvnqfjz	Castilla, V.	The entry of Junin virus into Vero cells	1994		.txt	text/plain	2668	141	50	The entry mechanism of Junin virus (JV) into Vero cells was studied analyzing the effect of lysosomotropic compounds and acid pH on JV infection. Vero cells grown in coverslips were infected with JV (moi 1) and 15 mM ammonium chloride was added to the culture medium after adsorption. To reinforce that the membrane fusion activity of Junin virus is expressed at low pH, the formation of JV-induced syncytia in infected Vero cells incubated in medium at pH 5.5 or 7.5 was quantitated. In fact, a bypass of the ammonium chloride block of JV infection was achieved when the extracellular medium was at a pH below 6.1 (Fig. 5) , suggesting that the acidic conditions would probably trigger direct fusion of virus envelope with the cell membrane.	./cache/cord-004825-cdvnqfjz.txt	./txt/cord-004825-cdvnqfjz.txt