id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006674-ywzpwlrb	Ikeda, T.	Pathogenesis of cytomegalovirus-associated pneumonitis in ICR mice: possible involvement of superoxide radicals	1992		.txt	text/plain	3716	193	45	When the activity of xanthine oxidase (XO) in lung tissue homogenates was measured, the activity was found to significantly increase after intranasal infection with MCMV irrespective of CP administration and there was a good correlation between the elevation of XO activity and the degree of pathological changes in the lung. Furthermore, recent studies have shown that the enhanced production of superoxide radicals by xanthine oxidase (XO) plays a key role in the pathogenesis of influenza virus-induced pulmonary infection [1, 193. In this study, we have established a model of murine cytomegalovirus (MCMV) pneumonitis in ICR mice, measured XO activity in tung tissues, and evaluated the effect of superoxide dismutase (SOD) and allopurinol in this model. Although the precise role of superoxide radicals in the pathogenesis of MCMV pneumonitis is still unknown, such a process seems to be involved in the formation of pulmonary lesions in MCMV-infected mice.	./cache/cord-006674-ywzpwlrb.txt	./txt/cord-006674-ywzpwlrb.txt