id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-012032-zolowuhj	Yu, Peifa	2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705	2020-08-08		.txt	text/plain	3499	197	45	To further examine the antiviral effects, another murine macrophage cell line, J774A.1, was used, and a similar inhibitory effect of 2'-FdC on MNV-1 replication was observed, with decreased viral RNA and NS1/2 protein expression ( Supplementary Fig. 1 ). As shown in Fig. 3D and E, the viral NS1/2 protein expression and viral titers were further decreased when the antivirals were used in combination, supporting the synergistic antiviral effects of 2'-FdC with MPA, ribavirin, or T705 against MNV replication. The combined effect of 2'-FdC and ribavirin on viral replication was analyzed using a qRT-PCR assay (n = 2-4) and mathematical modeling using MacSynergy. RAW264.7 cells were infected with MNV-1 at an MOI of 1 for 1 h and then left untreated or treated with 2'-FdC and MPA, ribavirin, or T705 at the indicated concentrations for 20 h, alone or in combination.	./cache/cord-012032-zolowuhj.txt	./txt/cord-012032-zolowuhj.txt