id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-262505-1ufgwxxg	Lai, M. M. C.	Genetic heterogeneity of murine coronaviruses	1983		.txt	text/plain	2559	162	57	Several mouse hepatitis viruses (MHV) with different pathogenicity were studied by oligonucleotide fingerprinting. The MHVs isolated from separate cloned neuroblastoma cell lines persistently infected with JHM strain were also found to have diverged more markedly than the corresponding virus maintained under the conditions of lytic infection. The viruses maintained under the latter conditions exhibit much more variability, suggesting that persistent infections may be a mechanism contributing to the genetic heterogeneity of the current MHV strains. To study the genetic relationship of different MHV strains causing various diseases in mice, we first examined the oligonucleotide fingerprints of two of the IKHVs isolated in Japan. To assess the genetic stability and variability of MItV and to study the possible mechanism of viral divergence observed as above, we examined the heterogeneity of viral genomic sequences in viruses isolated from persistently and latently infected cells.	./cache/cord-262505-1ufgwxxg.txt	./txt/cord-262505-1ufgwxxg.txt