id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289926-y1rjgbui	Veretnik, S.	RNA binding domain of HDV antigen is homologous to the HMG box of SRY	2014-05-18		.txt	text/plain	6679	309	53	Using sequence analysis methods we have discovered significant sequence similarity between this central domain of HDAg and the HMG (High Mobility Group) box of the SRY gene [40] , whose product binds to DNA and is essential for sex determination. The sequence similarity between the central domain of HDAg and the HMG (High Mobility Group) box of the SRY gene suggests that SRY may be a cellular cognate of HDAg. Another candidate for the 'captured' cellular RNA was recently proposed: a 202 residue cellular protein referred to as DIPA (delta interacting protein A) was identified by co-immunoprecipitation with HDAg and by its in vivo ability to inhibit viral replication [5] . Statistically significant sequence similarities are limited to the functionally essential regions of both genes: in the SRY gene the similarity is confined to the HMG (High Mobility Group) box, a DNA binding motif found in the HMG protein superfamily [24, 31] , in HDAg the similarity is limited to RNA-binding domain.	./cache/cord-289926-y1rjgbui.txt	./txt/cord-289926-y1rjgbui.txt