id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-294467-kq5wmavt	Kasai, H.	Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies	2014-04-08		.txt	text/plain	1947	116	60	title: Characterization of haemagglutinin-esterase protein (HE) of murine corona virus DVIM by monoclonal antibodies We analyzed the characteristics of seven monoclonal antibodies (mAbs) raised against purified HE (hemagglutinin-esterase) glycoprotein of the murine coronavirus DVIM (diarrhea virus of infant mice). Neutralizing activity was shown in group A mAbs exclusively, suggesting that the ratio of HA and/or AE activities may play important roles in the cell fusion activity of DVIM-infected cells. As described in a previous report [8] , by treatment of DVIM with the non-ionic detergent NP-40 we isolated the HE protein, which carries the functional sites for both acetylesterase (AE) and the haemagglutination (HA) activities. We examined the cytopathic effect of mAbs with respect to the formation of syncytia in DVIM-infected cells. The antibodies that had low titers to both activities did not delay the fusion of infected cells.	./cache/cord-294467-kq5wmavt.txt	./txt/cord-294467-kq5wmavt.txt