id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321471-gev5xq3a	Zhu, Liqian	Control of the PI3K/Akt pathway by porcine reproductive and respiratory syndrome virus	2013-02-05		.txt	text/plain	3759	181	50	The activation of PI3K-Akt pathway promotes cell survival by the phosphorylation of numerous substrates such as glycogen synthase kinase-3 (GSK-3), FoxO1, Bad and mTOR [5, 11, 24, 36, 38] . Previous studies have shown that during PRRSV infection of porcine monocyte-derived dendritic cells (Mo-DCs), the PI3K/Akt pathway is activated at 90 min and 4 h postinfection (h p.i.), and it is inhibited at 12 h p.i. A number of studies have shown that the PI3K/Akt signaling pathway is functionally dependent on downstream substrates of Akt such as FoxO1, Bad and mTOR for regulation of cell survival [3, 11, 15, 25] . Since increased phosphorylation of Akt induced by HP-PRRSV was observed at 5 min and 15 min postinfection in virus-infected MARC-145 cells, and at 5, 15 and 30 min postinfection in PAMs, we hypothesized that the virus entry process accounted for this early-stage activation.	./cache/cord-321471-gev5xq3a.txt	./txt/cord-321471-gev5xq3a.txt