id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-324377-br2uorg8	Zhou, Pei	Antiviral effect of lithium chloride on infection of cells by canine parvovirus	2015-08-28		.txt	text/plain	2930	164	58	We determined the antiviral effect of Lithium Chloride on canine parvovirus type 2 in feline kidney cells. These results indicated that lithium chloride could be a potential antiviral drug for curing dogs with canine parvovirus infection. The specific steps of canine parvovirus entry into cells that are affected by lithium chloride and its antiviral effect in vivo should be explored in future studies. As a control, cells infected with the same dose of CPV were not treated with LiCl. Subsequently, the antiviral efficacy was evaluated by analysis of viral RNA levels, protein expression level and CPE. These results indicate that treatment of F81 cells with LiCl inhibits CPV infection and reduces the cytopathic effect in a dose-dependent manner. No significant differences in the relative levels of viral VP2 gene DNA or viral titers were observed between drug-treated and mocktreated cells, indicating that LiCl had no effect on CPV attachment and replication in F81 cells ( Fig. 4A and B) .	./cache/cord-324377-br2uorg8.txt	./txt/cord-324377-br2uorg8.txt