id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-345856-ckm0ol20	Zhong, Qiong	Antiviral activity of Arbidol against Coxsackie virus B5 in vitro and in vivo	2009-03-17		.txt	text/plain	3778	200	58	Arbidol not only prevented the cytopathic effect (CPE) of CVB(5), as demonstrated in an MTT colorimetric assay, when added during or after viral infection, with a 50% inhibitory concentration (IC(50)) from 2.66 to 6.62 μg/ml, but it also decreased the CVB(5)-RNA level in infected host cells, as shown in semi-quantitative RT-PCR. Orally administered Arbidol at 50 mg/kg body weight/day (once a day) significantly reduced mean virus yields in the lungs and heart as well as mortality after infection for 6 days. In our previous study, Arbidol showed broad-spectrum antiviral activity against a number of respiratory viruses, including FLU-A, RSV, HRV 14, and CVB 3 in vitro [20] . The virus titers of lung and heart were significantly lower in mice receiving oral administration of Arbidol daily for 6 days than in the viral control group. We also cocultured HEp-2 cells with different doses of Arbidol after infection to study whether it still had an antiviral effect after virus entry into the host cell.	./cache/cord-345856-ckm0ol20.txt	./txt/cord-345856-ckm0ol20.txt