id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346321-drhiqch0	Hohdatsu, T.	The role of IgG subclass of mouse monoclonal antibodies in antibody-dependent enhancement of feline infectious peritonitis virus infection of feline macrophages	1994		.txt	text/plain	3722	165	53	title: The role of IgG subclass of mouse monoclonal antibodies in antibody-dependent enhancement of feline infectious peritonitis virus infection of feline macrophages Antibody-dependent enhancement (ADE) of feline infectious peritonitis virus (FIPV) infection was studied in feline alveolar macrophages and human monocyte cell line U937 using mouse neutralizing monoclonal antibodies (MAbs) directed to the spike protein of FIPV. It is especially important for development of vaccines to understand the relationship between FIPV neutralizing activity and ADE activity of anti FIPV MAbs. In this study, we determined the relationship between immunoglobulin subclass and ADE activity of FIPV-neutralizing MAbs, and attempted to explore mechanisms of ADE of FIPV infection in in vitro system using mouse MAbs and feline alveolar macrophages or human monocytes. The present study, however, explored ADE of FIPV infection by in vitro experiments in which xenogeneic combination of virus targets and anti-FIPV antibody, i.e., feline alveolar macrophages or human monocyte U937 cells and mouse anti-FIPV S protein MAbs, was used.	./cache/cord-346321-drhiqch0.txt	./txt/cord-346321-drhiqch0.txt