id sid tid token lemma pos cord-289926-y1rjgbui 1 1 key key JJ cord-289926-y1rjgbui 1 2 : : : cord-289926-y1rjgbui 1 3 cord-289926-y1rjgbui cord-289926-y1rjgbui JJ cord-289926-y1rjgbui 1 4 authors author NNS cord-289926-y1rjgbui 1 5 : : : cord-289926-y1rjgbui 1 6 Veretnik Veretnik NNP cord-289926-y1rjgbui 1 7 , , , cord-289926-y1rjgbui 1 8 S. S. NNP cord-289926-y1rjgbui 1 9 ; ; : cord-289926-y1rjgbui 1 10 Gribskov Gribskov NNP cord-289926-y1rjgbui 1 11 , , , cord-289926-y1rjgbui 1 12 M. M. NNP cord-289926-y1rjgbui 1 13 title title NN cord-289926-y1rjgbui 1 14 : : : cord-289926-y1rjgbui 1 15 RNA rna NN cord-289926-y1rjgbui 1 16 binding binding NN cord-289926-y1rjgbui 1 17 domain domain NN cord-289926-y1rjgbui 1 18 of of IN cord-289926-y1rjgbui 1 19 HDV HDV NNP cord-289926-y1rjgbui 1 20 antigen antigen NN cord-289926-y1rjgbui 1 21 is be VBZ cord-289926-y1rjgbui 1 22 homologous homologous JJ cord-289926-y1rjgbui 1 23 to to IN cord-289926-y1rjgbui 1 24 the the DT cord-289926-y1rjgbui 1 25 HMG HMG NNP cord-289926-y1rjgbui 1 26 box box NN cord-289926-y1rjgbui 1 27 of of IN cord-289926-y1rjgbui 1 28 SRY SRY NNP cord-289926-y1rjgbui 1 29 date date NN cord-289926-y1rjgbui 2 1 : : : cord-289926-y1rjgbui 2 2 2014 2014 CD cord-289926-y1rjgbui 2 3 - - HYPH cord-289926-y1rjgbui 2 4 05 05 CD cord-289926-y1rjgbui 2 5 - - SYM cord-289926-y1rjgbui 2 6 18 18 CD cord-289926-y1rjgbui 2 7 journal journal NN cord-289926-y1rjgbui 2 8 : : : cord-289926-y1rjgbui 3 1 Arch Arch NNP cord-289926-y1rjgbui 3 2 Virol Virol NNP cord-289926-y1rjgbui 4 1 DOI DOI NNP cord-289926-y1rjgbui 4 2 : : : cord-289926-y1rjgbui 4 3 10.1007 10.1007 CD cord-289926-y1rjgbui 4 4 / / SYM cord-289926-y1rjgbui 4 5 s007050050575 s007050050575 NNP cord-289926-y1rjgbui 4 6 sha sha NNP cord-289926-y1rjgbui 4 7 : : : cord-289926-y1rjgbui 4 8 469eb25bd5ef12981ba86af96534a884fcc8a524 469eb25bd5ef12981ba86af96534a884fcc8a524 CD cord-289926-y1rjgbui 4 9 doc_id doc_id CD cord-289926-y1rjgbui 4 10 : : : cord-289926-y1rjgbui 4 11 289926 289926 CD cord-289926-y1rjgbui 4 12 cord_uid cord_uid NNS cord-289926-y1rjgbui 4 13 : : : cord-289926-y1rjgbui 5 1 y1rjgbui y1rjgbui NNP cord-289926-y1rjgbui 6 1 The the DT cord-289926-y1rjgbui 6 2 delta delta NN cord-289926-y1rjgbui 6 3 antigen antigen NN cord-289926-y1rjgbui 6 4 of of IN cord-289926-y1rjgbui 6 5 hepatitis hepatitis NNP cord-289926-y1rjgbui 6 6 delta delta NNP cord-289926-y1rjgbui 6 7 virus virus NN cord-289926-y1rjgbui 6 8 exhibits exhibit VBZ cord-289926-y1rjgbui 6 9 sequence sequence NN cord-289926-y1rjgbui 6 10 specific specific JJ cord-289926-y1rjgbui 6 11 binding binding NN cord-289926-y1rjgbui 6 12 to to IN cord-289926-y1rjgbui 6 13 its -PRON- PRP$ cord-289926-y1rjgbui 6 14 own own JJ cord-289926-y1rjgbui 6 15 RNA RNA NNP cord-289926-y1rjgbui 6 16 and and CC cord-289926-y1rjgbui 6 17 is be VBZ cord-289926-y1rjgbui 6 18 essential essential JJ cord-289926-y1rjgbui 6 19 for for IN cord-289926-y1rjgbui 6 20 viral viral JJ cord-289926-y1rjgbui 6 21 replication replication NN cord-289926-y1rjgbui 6 22 . . . cord-289926-y1rjgbui 7 1 Using use VBG cord-289926-y1rjgbui 7 2 statistical statistical JJ cord-289926-y1rjgbui 7 3 methods method NNS cord-289926-y1rjgbui 7 4 we -PRON- PRP cord-289926-y1rjgbui 7 5 have have VBP cord-289926-y1rjgbui 7 6 detected detect VBN cord-289926-y1rjgbui 7 7 significant significant JJ cord-289926-y1rjgbui 7 8 similarity similarity NN cord-289926-y1rjgbui 7 9 between between IN cord-289926-y1rjgbui 7 10 the the DT cord-289926-y1rjgbui 7 11 RNA RNA NNP cord-289926-y1rjgbui 7 12 - - HYPH cord-289926-y1rjgbui 7 13 binding bind VBG cord-289926-y1rjgbui 7 14 domain domain NN cord-289926-y1rjgbui 7 15 of of IN cord-289926-y1rjgbui 7 16 the the DT cord-289926-y1rjgbui 7 17 hepatitis hepatitis NN cord-289926-y1rjgbui 7 18 delta delta NNP cord-289926-y1rjgbui 7 19 antigen antigen NNP cord-289926-y1rjgbui 7 20 and and CC cord-289926-y1rjgbui 7 21 the the DT cord-289926-y1rjgbui 7 22 HMG HMG NNP cord-289926-y1rjgbui 7 23 box box NN cord-289926-y1rjgbui 7 24 of of IN cord-289926-y1rjgbui 7 25 SRY SRY NNP cord-289926-y1rjgbui 7 26 . . . cord-289926-y1rjgbui 8 1 Our -PRON- PRP$ cord-289926-y1rjgbui 8 2 analysis analysis NN cord-289926-y1rjgbui 8 3 suggests suggest VBZ cord-289926-y1rjgbui 8 4 that that IN cord-289926-y1rjgbui 8 5 the the DT cord-289926-y1rjgbui 8 6 RNA RNA NNP cord-289926-y1rjgbui 8 7 - - HYPH cord-289926-y1rjgbui 8 8 binding bind VBG cord-289926-y1rjgbui 8 9 domain domain NN cord-289926-y1rjgbui 8 10 of of IN cord-289926-y1rjgbui 8 11 HDV HDV NNP cord-289926-y1rjgbui 8 12 antigen antigen NN cord-289926-y1rjgbui 8 13 evolved evolve VBD cord-289926-y1rjgbui 8 14 from from IN cord-289926-y1rjgbui 8 15 the the DT cord-289926-y1rjgbui 8 16 DNA dna NN cord-289926-y1rjgbui 8 17 - - HYPH cord-289926-y1rjgbui 8 18 binding bind VBG cord-289926-y1rjgbui 8 19 domain domain NN cord-289926-y1rjgbui 8 20 of of IN cord-289926-y1rjgbui 8 21 the the DT cord-289926-y1rjgbui 8 22 HMG HMG NNP cord-289926-y1rjgbui 8 23 box box NN cord-289926-y1rjgbui 8 24 . . . cord-289926-y1rjgbui 9 1 SRY sry UH cord-289926-y1rjgbui 9 2 , , , cord-289926-y1rjgbui 9 3 or or CC cord-289926-y1rjgbui 9 4 a a DT cord-289926-y1rjgbui 9 5 related related JJ cord-289926-y1rjgbui 9 6 protein protein NN cord-289926-y1rjgbui 9 7 , , , cord-289926-y1rjgbui 9 8 is be VBZ cord-289926-y1rjgbui 9 9 a a DT cord-289926-y1rjgbui 9 10 probable probable JJ cord-289926-y1rjgbui 9 11 cellular cellular JJ cord-289926-y1rjgbui 9 12 cognate cognate NN cord-289926-y1rjgbui 9 13 of of IN cord-289926-y1rjgbui 9 14 HDV HDV NNP cord-289926-y1rjgbui 9 15 . . . cord-289926-y1rjgbui 10 1 Hepatitis Hepatitis NNP cord-289926-y1rjgbui 10 2 delta delta NN cord-289926-y1rjgbui 10 3 virus virus NN cord-289926-y1rjgbui 10 4 ( ( -LRB- cord-289926-y1rjgbui 10 5 HDV HDV NNP cord-289926-y1rjgbui 10 6 ) ) -RRB- cord-289926-y1rjgbui 10 7 , , , cord-289926-y1rjgbui 10 8 the the DT cord-289926-y1rjgbui 10 9 satellite satellite NN cord-289926-y1rjgbui 10 10 of of IN cord-289926-y1rjgbui 10 11 hepatitis hepatitis NNP cord-289926-y1rjgbui 10 12 B B NNP cord-289926-y1rjgbui 10 13 virus virus NN cord-289926-y1rjgbui 10 14 ( ( -LRB- cord-289926-y1rjgbui 10 15 HBV HBV NNP cord-289926-y1rjgbui 10 16 ) ) -RRB- cord-289926-y1rjgbui 10 17 is be VBZ cord-289926-y1rjgbui 10 18 unique unique JJ cord-289926-y1rjgbui 10 19 among among IN cord-289926-y1rjgbui 10 20 animal animal NN cord-289926-y1rjgbui 10 21 viruses virus NNS cord-289926-y1rjgbui 10 22 in in IN cord-289926-y1rjgbui 10 23 that that IN cord-289926-y1rjgbui 10 24 it -PRON- PRP cord-289926-y1rjgbui 10 25 contains contain VBZ cord-289926-y1rjgbui 10 26 a a DT cord-289926-y1rjgbui 10 27 circular circular JJ cord-289926-y1rjgbui 10 28 , , , cord-289926-y1rjgbui 10 29 viroid viroid JJ cord-289926-y1rjgbui 10 30 - - HYPH cord-289926-y1rjgbui 10 31 like like JJ cord-289926-y1rjgbui 10 32 RNA RNA NNP cord-289926-y1rjgbui 10 33 genome genome NN cord-289926-y1rjgbui 10 34 . . . cord-289926-y1rjgbui 11 1 While while IN cord-289926-y1rjgbui 11 2 it -PRON- PRP cord-289926-y1rjgbui 11 3 is be VBZ cord-289926-y1rjgbui 11 4 fully fully RB cord-289926-y1rjgbui 11 5 dependent dependent JJ cord-289926-y1rjgbui 11 6 on on IN cord-289926-y1rjgbui 11 7 the the DT cord-289926-y1rjgbui 11 8 helper helper NN cord-289926-y1rjgbui 11 9 virus virus NN cord-289926-y1rjgbui 11 10 for for IN cord-289926-y1rjgbui 11 11 its -PRON- PRP$ cord-289926-y1rjgbui 11 12 packaging packaging NN cord-289926-y1rjgbui 11 13 , , , cord-289926-y1rjgbui 11 14 HDV HDV NNP cord-289926-y1rjgbui 11 15 has have VBZ cord-289926-y1rjgbui 11 16 no no DT cord-289926-y1rjgbui 11 17 significant significant JJ cord-289926-y1rjgbui 11 18 sequence sequence NN cord-289926-y1rjgbui 11 19 similarity similarity NN cord-289926-y1rjgbui 11 20 to to IN cord-289926-y1rjgbui 11 21 HBV HBV NNP cord-289926-y1rjgbui 11 22 ; ; : cord-289926-y1rjgbui 11 23 its -PRON- PRP$ cord-289926-y1rjgbui 11 24 replication replication NN cord-289926-y1rjgbui 11 25 is be VBZ cord-289926-y1rjgbui 11 26 independent independent JJ cord-289926-y1rjgbui 11 27 of of IN cord-289926-y1rjgbui 11 28 HBV HBV NNP cord-289926-y1rjgbui 11 29 and and CC cord-289926-y1rjgbui 11 30 its -PRON- PRP$ cord-289926-y1rjgbui 11 31 geographic geographic JJ cord-289926-y1rjgbui 11 32 prevalence prevalence NN cord-289926-y1rjgbui 11 33 is be VBZ cord-289926-y1rjgbui 11 34 different different JJ cord-289926-y1rjgbui 11 35 [ [ -LRB- cord-289926-y1rjgbui 11 36 30 30 CD cord-289926-y1rjgbui 11 37 ] ] -RRB- cord-289926-y1rjgbui 11 38 . . . cord-289926-y1rjgbui 12 1 HDV HDV NNP cord-289926-y1rjgbui 12 2 is be VBZ cord-289926-y1rjgbui 12 3 a a DT cord-289926-y1rjgbui 12 4 single single JJ cord-289926-y1rjgbui 12 5 stranded strand VBN cord-289926-y1rjgbui 12 6 RNA RNA NNP cord-289926-y1rjgbui 12 7 virus virus NN cord-289926-y1rjgbui 12 8 . . . cord-289926-y1rjgbui 13 1 It -PRON- PRP cord-289926-y1rjgbui 13 2 replicates replicate VBZ cord-289926-y1rjgbui 13 3 through through IN cord-289926-y1rjgbui 13 4 a a DT cord-289926-y1rjgbui 13 5 double double JJ cord-289926-y1rjgbui 13 6 rolling rolling JJ cord-289926-y1rjgbui 13 7 - - HYPH cord-289926-y1rjgbui 13 8 circle circle NN cord-289926-y1rjgbui 13 9 mechanism mechanism NN cord-289926-y1rjgbui 13 10 , , , cord-289926-y1rjgbui 13 11 probably probably RB cord-289926-y1rjgbui 13 12 using use VBG cord-289926-y1rjgbui 13 13 RNA RNA NNP cord-289926-y1rjgbui 13 14 polymerase polymerase NN cord-289926-y1rjgbui 13 15 II II NNP cord-289926-y1rjgbui 13 16 and and CC cord-289926-y1rjgbui 13 17 cellular cellular JJ cord-289926-y1rjgbui 13 18 transcriptional transcriptional JJ cord-289926-y1rjgbui 13 19 machinery machinery NN cord-289926-y1rjgbui 13 20 [ [ -LRB- cord-289926-y1rjgbui 13 21 8 8 CD cord-289926-y1rjgbui 13 22 , , , cord-289926-y1rjgbui 13 23 22 22 CD cord-289926-y1rjgbui 13 24 ] ] -RRB- cord-289926-y1rjgbui 13 25 . . . cord-289926-y1rjgbui 14 1 Two two CD cord-289926-y1rjgbui 14 2 detectable detectable JJ cord-289926-y1rjgbui 14 3 HDV HDV NNP cord-289926-y1rjgbui 14 4 antigens antigen NNS cord-289926-y1rjgbui 14 5 ( ( -LRB- cord-289926-y1rjgbui 14 6 HDAg HDAg NNP cord-289926-y1rjgbui 14 7 ) ) -RRB- cord-289926-y1rjgbui 14 8 are be VBP cord-289926-y1rjgbui 14 9 encoded encode VBN cord-289926-y1rjgbui 14 10 by by IN cord-289926-y1rjgbui 14 11 a a DT cord-289926-y1rjgbui 14 12 single single JJ cord-289926-y1rjgbui 14 13 open open JJ cord-289926-y1rjgbui 14 14 reading reading NN cord-289926-y1rjgbui 14 15 frame frame NN cord-289926-y1rjgbui 14 16 on on IN cord-289926-y1rjgbui 14 17 the the DT cord-289926-y1rjgbui 14 18 antigenomic antigenomic JJ cord-289926-y1rjgbui 14 19 strand strand NN cord-289926-y1rjgbui 14 20 . . . cord-289926-y1rjgbui 15 1 The the DT cord-289926-y1rjgbui 15 2 large large JJ cord-289926-y1rjgbui 15 3 antigen antigen NN cord-289926-y1rjgbui 15 4 ( ( -LRB- cord-289926-y1rjgbui 15 5 L l NN cord-289926-y1rjgbui 15 6 - - HYPH cord-289926-y1rjgbui 15 7 HDAg HDAg NNP cord-289926-y1rjgbui 15 8 ) ) -RRB- cord-289926-y1rjgbui 15 9 is be VBZ cord-289926-y1rjgbui 15 10 a a DT cord-289926-y1rjgbui 15 11 result result NN cord-289926-y1rjgbui 15 12 of of IN cord-289926-y1rjgbui 15 13 RNA RNA NNP cord-289926-y1rjgbui 15 14 editing editing NN cord-289926-y1rjgbui 15 15 which which WDT cord-289926-y1rjgbui 15 16 extends extend VBZ cord-289926-y1rjgbui 15 17 the the DT cord-289926-y1rjgbui 15 18 protein protein NN cord-289926-y1rjgbui 15 19 coding code VBG cord-289926-y1rjgbui 15 20 sequence sequence NN cord-289926-y1rjgbui 15 21 of of IN cord-289926-y1rjgbui 15 22 the the DT cord-289926-y1rjgbui 15 23 small small JJ cord-289926-y1rjgbui 15 24 antigen antigen NN cord-289926-y1rjgbui 15 25 ( ( -LRB- cord-289926-y1rjgbui 15 26 S s NN cord-289926-y1rjgbui 15 27 - - HYPH cord-289926-y1rjgbui 15 28 HDAg HDAg NNP cord-289926-y1rjgbui 15 29 ) ) -RRB- cord-289926-y1rjgbui 15 30 by by IN cord-289926-y1rjgbui 15 31 19 19 CD cord-289926-y1rjgbui 15 32 residues residue NNS cord-289926-y1rjgbui 15 33 ; ; : cord-289926-y1rjgbui 15 34 L l NN cord-289926-y1rjgbui 15 35 - - HYPH cord-289926-y1rjgbui 15 36 HDAg HDAg NNP cord-289926-y1rjgbui 15 37 appears appear VBZ cord-289926-y1rjgbui 15 38 later later RB cord-289926-y1rjgbui 15 39 in in IN cord-289926-y1rjgbui 15 40 infection infection NN cord-289926-y1rjgbui 15 41 , , , cord-289926-y1rjgbui 15 42 suppresses suppress VBZ cord-289926-y1rjgbui 15 43 replication replication NN cord-289926-y1rjgbui 15 44 and and CC cord-289926-y1rjgbui 15 45 initiates initiate VBZ cord-289926-y1rjgbui 15 46 viral viral JJ cord-289926-y1rjgbui 15 47 packaging packaging NN cord-289926-y1rjgbui 15 48 [ [ -LRB- cord-289926-y1rjgbui 15 49 7 7 CD cord-289926-y1rjgbui 15 50 , , , cord-289926-y1rjgbui 15 51 25 25 CD cord-289926-y1rjgbui 15 52 ] ] -RRB- cord-289926-y1rjgbui 15 53 . . . cord-289926-y1rjgbui 16 1 The the DT cord-289926-y1rjgbui 16 2 small small JJ cord-289926-y1rjgbui 16 3 antigen antigen NN cord-289926-y1rjgbui 16 4 ( ( -LRB- cord-289926-y1rjgbui 16 5 S s NN cord-289926-y1rjgbui 16 6 - - HYPH cord-289926-y1rjgbui 16 7 HDAg HDAg NNP cord-289926-y1rjgbui 16 8 ) ) -RRB- cord-289926-y1rjgbui 16 9 is be VBZ cord-289926-y1rjgbui 16 10 essential essential JJ cord-289926-y1rjgbui 16 11 for for IN cord-289926-y1rjgbui 16 12 viral viral JJ cord-289926-y1rjgbui 16 13 replication replication NN cord-289926-y1rjgbui 16 14 and and CC cord-289926-y1rjgbui 16 15 is be VBZ cord-289926-y1rjgbui 16 16 proposed propose VBN cord-289926-y1rjgbui 16 17 to to TO cord-289926-y1rjgbui 16 18 facilitate facilitate VB cord-289926-y1rjgbui 16 19 the the DT cord-289926-y1rjgbui 16 20 interactions interaction NNS cord-289926-y1rjgbui 16 21 between between IN cord-289926-y1rjgbui 16 22 the the DT cord-289926-y1rjgbui 16 23 cellular cellular JJ cord-289926-y1rjgbui 16 24 transcriptional transcriptional JJ cord-289926-y1rjgbui 16 25 machinery machinery NN cord-289926-y1rjgbui 16 26 and and CC cord-289926-y1rjgbui 16 27 the the DT cord-289926-y1rjgbui 16 28 viral viral JJ cord-289926-y1rjgbui 16 29 template template NN cord-289926-y1rjgbui 16 30 . . . cord-289926-y1rjgbui 17 1 The the DT cord-289926-y1rjgbui 17 2 central central JJ cord-289926-y1rjgbui 17 3 domain domain NN cord-289926-y1rjgbui 17 4 of of IN cord-289926-y1rjgbui 17 5 S s NN cord-289926-y1rjgbui 17 6 - - HYPH cord-289926-y1rjgbui 17 7 HDAg HDAg NNS cord-289926-y1rjgbui 17 8 , , , cord-289926-y1rjgbui 17 9 which which WDT cord-289926-y1rjgbui 17 10 is be VBZ cord-289926-y1rjgbui 17 11 involved involve VBN cord-289926-y1rjgbui 17 12 in in IN cord-289926-y1rjgbui 17 13 binding bind VBG cord-289926-y1rjgbui 17 14 to to IN cord-289926-y1rjgbui 17 15 the the DT cord-289926-y1rjgbui 17 16 viral viral JJ cord-289926-y1rjgbui 17 17 genome genome NN cord-289926-y1rjgbui 17 18 , , , cord-289926-y1rjgbui 17 19 contains contain VBZ cord-289926-y1rjgbui 17 20 two two CD cord-289926-y1rjgbui 17 21 arginine arginine NN cord-289926-y1rjgbui 17 22 - - HYPH cord-289926-y1rjgbui 17 23 rich rich JJ cord-289926-y1rjgbui 17 24 motifs motif NNS cord-289926-y1rjgbui 17 25 ( ( -LRB- cord-289926-y1rjgbui 17 26 ARMs arm NNS cord-289926-y1rjgbui 17 27 ) ) -RRB- cord-289926-y1rjgbui 17 28 bracketing bracket VBG cord-289926-y1rjgbui 17 29 a a DT cord-289926-y1rjgbui 17 30 leucine leucine NN cord-289926-y1rjgbui 17 31 zipper zipper NN cord-289926-y1rjgbui 17 32 . . . cord-289926-y1rjgbui 18 1 Mutational mutational JJ cord-289926-y1rjgbui 18 2 analysis analysis NN cord-289926-y1rjgbui 18 3 indicates indicate VBZ cord-289926-y1rjgbui 18 4 that that IN cord-289926-y1rjgbui 18 5 both both CC cord-289926-y1rjgbui 18 6 the the DT cord-289926-y1rjgbui 18 7 ARMs arm NNS cord-289926-y1rjgbui 18 8 and and CC cord-289926-y1rjgbui 18 9 the the DT cord-289926-y1rjgbui 18 10 leucine leucine NN cord-289926-y1rjgbui 18 11 zipper zipper NN cord-289926-y1rjgbui 18 12 region region NN cord-289926-y1rjgbui 18 13 are be VBP cord-289926-y1rjgbui 18 14 essential essential JJ cord-289926-y1rjgbui 18 15 for for IN cord-289926-y1rjgbui 18 16 binding bind VBG cord-289926-y1rjgbui 18 17 to to IN cord-289926-y1rjgbui 18 18 the the DT cord-289926-y1rjgbui 18 19 HDV HDV NNP cord-289926-y1rjgbui 18 20 genome genome NN cord-289926-y1rjgbui 18 21 [ [ -LRB- cord-289926-y1rjgbui 18 22 32 32 CD cord-289926-y1rjgbui 18 23 ] ] -RRB- cord-289926-y1rjgbui 18 24 . . . cord-289926-y1rjgbui 19 1 Using use VBG cord-289926-y1rjgbui 19 2 sequence sequence NN cord-289926-y1rjgbui 19 3 analysis analysis NN cord-289926-y1rjgbui 19 4 methods method NNS cord-289926-y1rjgbui 19 5 we -PRON- PRP cord-289926-y1rjgbui 19 6 have have VBP cord-289926-y1rjgbui 19 7 discovered discover VBN cord-289926-y1rjgbui 19 8 significant significant JJ cord-289926-y1rjgbui 19 9 sequence sequence NN cord-289926-y1rjgbui 19 10 similarity similarity NN cord-289926-y1rjgbui 19 11 between between IN cord-289926-y1rjgbui 19 12 this this DT cord-289926-y1rjgbui 19 13 central central JJ cord-289926-y1rjgbui 19 14 domain domain NN cord-289926-y1rjgbui 19 15 of of IN cord-289926-y1rjgbui 19 16 HDAg hdag NN cord-289926-y1rjgbui 19 17 and and CC cord-289926-y1rjgbui 19 18 the the DT cord-289926-y1rjgbui 19 19 HMG HMG NNP cord-289926-y1rjgbui 19 20 ( ( -LRB- cord-289926-y1rjgbui 19 21 High High NNP cord-289926-y1rjgbui 19 22 Mobility Mobility NNP cord-289926-y1rjgbui 19 23 Group Group NNP cord-289926-y1rjgbui 19 24 ) ) -RRB- cord-289926-y1rjgbui 19 25 box box NN cord-289926-y1rjgbui 19 26 of of IN cord-289926-y1rjgbui 19 27 the the DT cord-289926-y1rjgbui 19 28 SRY SRY NNP cord-289926-y1rjgbui 19 29 gene gene NN cord-289926-y1rjgbui 19 30 [ [ -LRB- cord-289926-y1rjgbui 19 31 40 40 CD cord-289926-y1rjgbui 19 32 ] ] -RRB- cord-289926-y1rjgbui 19 33 , , , cord-289926-y1rjgbui 19 34 whose whose WP$ cord-289926-y1rjgbui 19 35 product product NN cord-289926-y1rjgbui 19 36 binds bind VBZ cord-289926-y1rjgbui 19 37 to to IN cord-289926-y1rjgbui 19 38 DNA dna NN cord-289926-y1rjgbui 19 39 and and CC cord-289926-y1rjgbui 19 40 is be VBZ cord-289926-y1rjgbui 19 41 essential essential JJ cord-289926-y1rjgbui 19 42 for for IN cord-289926-y1rjgbui 19 43 sex sex NN cord-289926-y1rjgbui 19 44 determination determination NN cord-289926-y1rjgbui 19 45 . . . cord-289926-y1rjgbui 20 1 Our -PRON- PRP$ cord-289926-y1rjgbui 20 2 results result NNS cord-289926-y1rjgbui 20 3 indicate indicate VBP cord-289926-y1rjgbui 20 4 a a DT cord-289926-y1rjgbui 20 5 possible possible JJ cord-289926-y1rjgbui 20 6 evolution evolution NN cord-289926-y1rjgbui 20 7 of of IN cord-289926-y1rjgbui 20 8 this this DT cord-289926-y1rjgbui 20 9 widely widely RB cord-289926-y1rjgbui 20 10 used use VBN cord-289926-y1rjgbui 20 11 DNA dna NN cord-289926-y1rjgbui 20 12 - - HYPH cord-289926-y1rjgbui 20 13 binding bind VBG cord-289926-y1rjgbui 20 14 domain domain NN cord-289926-y1rjgbui 20 15 into into IN cord-289926-y1rjgbui 20 16 the the DT cord-289926-y1rjgbui 20 17 RNA RNA NNP cord-289926-y1rjgbui 20 18 - - HYPH cord-289926-y1rjgbui 20 19 binding bind VBG cord-289926-y1rjgbui 20 20 domain domain NN cord-289926-y1rjgbui 20 21 of of IN cord-289926-y1rjgbui 20 22 HDAg HDAg NNS cord-289926-y1rjgbui 20 23 . . . cord-289926-y1rjgbui 21 1 The the DT cord-289926-y1rjgbui 21 2 organization organization NN cord-289926-y1rjgbui 21 3 of of IN cord-289926-y1rjgbui 21 4 the the DT cord-289926-y1rjgbui 21 5 HDV HDV NNP cord-289926-y1rjgbui 21 6 genome genome NN cord-289926-y1rjgbui 21 7 suggests suggest VBZ cord-289926-y1rjgbui 21 8 two two CD cord-289926-y1rjgbui 21 9 distinct distinct JJ cord-289926-y1rjgbui 21 10 sources source NNS cord-289926-y1rjgbui 21 11 for for IN cord-289926-y1rjgbui 21 12 its -PRON- PRP$ cord-289926-y1rjgbui 21 13 genomic genomic JJ cord-289926-y1rjgbui 21 14 RNA RNA NNP cord-289926-y1rjgbui 21 15 : : : cord-289926-y1rjgbui 21 16 25 25 CD cord-289926-y1rjgbui 21 17 % % NN cord-289926-y1rjgbui 21 18 of of IN cord-289926-y1rjgbui 21 19 the the DT cord-289926-y1rjgbui 21 20 genome genome NN cord-289926-y1rjgbui 21 21 resembles resemble VBZ cord-289926-y1rjgbui 21 22 a a DT cord-289926-y1rjgbui 21 23 plant plant NN cord-289926-y1rjgbui 21 24 viroid viroid NNP cord-289926-y1rjgbui 21 25 RNA RNA NNP cord-289926-y1rjgbui 21 26 ( ( -LRB- cord-289926-y1rjgbui 21 27 the the DT cord-289926-y1rjgbui 21 28 smallest smallest RBS cord-289926-y1rjgbui 21 29 known know VBN cord-289926-y1rjgbui 21 30 self self NN cord-289926-y1rjgbui 21 31 - - HYPH cord-289926-y1rjgbui 21 32 replicating replicate VBG cord-289926-y1rjgbui 21 33 genome genome NN cord-289926-y1rjgbui 21 34 ) ) -RRB- cord-289926-y1rjgbui 21 35 , , , cord-289926-y1rjgbui 21 36 while while IN cord-289926-y1rjgbui 21 37 the the DT cord-289926-y1rjgbui 21 38 remaining remain VBG cord-289926-y1rjgbui 21 39 three three CD cord-289926-y1rjgbui 21 40 - - HYPH cord-289926-y1rjgbui 21 41 quarters quarter NNS cord-289926-y1rjgbui 21 42 of of IN cord-289926-y1rjgbui 21 43 the the DT cord-289926-y1rjgbui 21 44 genome genome NN cord-289926-y1rjgbui 21 45 is be VBZ cord-289926-y1rjgbui 21 46 more more JJR cord-289926-y1rjgbui 21 47 like like IN cord-289926-y1rjgbui 21 48 a a DT cord-289926-y1rjgbui 21 49 cellular cellular JJ cord-289926-y1rjgbui 21 50 RNA rna NN cord-289926-y1rjgbui 21 51 . . . cord-289926-y1rjgbui 22 1 Half half NN cord-289926-y1rjgbui 22 2 of of IN cord-289926-y1rjgbui 22 3 this this DT cord-289926-y1rjgbui 22 4 cellular cellular JJ cord-289926-y1rjgbui 22 5 domain domain NN cord-289926-y1rjgbui 22 6 codes code NNS cord-289926-y1rjgbui 22 7 for for IN cord-289926-y1rjgbui 22 8 HDAg HDAg NNS cord-289926-y1rjgbui 22 9 . . . cord-289926-y1rjgbui 23 1 This this DT cord-289926-y1rjgbui 23 2 unique unique JJ cord-289926-y1rjgbui 23 3 combination combination NN cord-289926-y1rjgbui 23 4 of of IN cord-289926-y1rjgbui 23 5 domains domain NNS cord-289926-y1rjgbui 23 6 within within IN cord-289926-y1rjgbui 23 7 HDV HDV NNP cord-289926-y1rjgbui 23 8 gave give VBD cord-289926-y1rjgbui 23 9 rise rise NN cord-289926-y1rjgbui 23 10 to to IN cord-289926-y1rjgbui 23 11 the the DT cord-289926-y1rjgbui 23 12 hypothesis hypothesis NN cord-289926-y1rjgbui 23 13 that that IN cord-289926-y1rjgbui 23 14 a a DT cord-289926-y1rjgbui 23 15 small small JJ cord-289926-y1rjgbui 23 16 viroid viroid NN cord-289926-y1rjgbui 23 17 ( ( -LRB- cord-289926-y1rjgbui 23 18 300 300 CD cord-289926-y1rjgbui 23 19 - - SYM cord-289926-y1rjgbui 23 20 400 400 CD cord-289926-y1rjgbui 23 21 bp bp NNP cord-289926-y1rjgbui 23 22 long long NNP cord-289926-y1rjgbui 23 23 ) ) -RRB- cord-289926-y1rjgbui 23 24 captured capture VBD cord-289926-y1rjgbui 23 25 a a DT cord-289926-y1rjgbui 23 26 cellular cellular JJ cord-289926-y1rjgbui 23 27 RNA RNA NNP cord-289926-y1rjgbui 23 28 , , , cord-289926-y1rjgbui 23 29 resulting result VBG cord-289926-y1rjgbui 23 30 in in IN cord-289926-y1rjgbui 23 31 a a DT cord-289926-y1rjgbui 23 32 larger large JJR cord-289926-y1rjgbui 23 33 virus virus NN cord-289926-y1rjgbui 23 34 that that WDT cord-289926-y1rjgbui 23 35 retained retain VBD cord-289926-y1rjgbui 23 36 the the DT cord-289926-y1rjgbui 23 37 ribozyme ribozyme NNS cord-289926-y1rjgbui 23 38 activities activity NNS cord-289926-y1rjgbui 23 39 of of IN cord-289926-y1rjgbui 23 40 the the DT cord-289926-y1rjgbui 23 41 viroid viroid JJ cord-289926-y1rjgbui 23 42 ( ( -LRB- cord-289926-y1rjgbui 23 43 such such JJ cord-289926-y1rjgbui 23 44 as as IN cord-289926-y1rjgbui 23 45 self self NN cord-289926-y1rjgbui 23 46 - - HYPH cord-289926-y1rjgbui 23 47 cleavage cleavage NN cord-289926-y1rjgbui 23 48 and and CC cord-289926-y1rjgbui 23 49 self self NN cord-289926-y1rjgbui 23 50 - - HYPH cord-289926-y1rjgbui 23 51 ligation ligation NN cord-289926-y1rjgbui 23 52 ) ) -RRB- cord-289926-y1rjgbui 23 53 [ [ -LRB- cord-289926-y1rjgbui 23 54 3 3 CD cord-289926-y1rjgbui 23 55 , , , cord-289926-y1rjgbui 23 56 39 39 CD cord-289926-y1rjgbui 23 57 ] ] -RRB- cord-289926-y1rjgbui 23 58 . . . cord-289926-y1rjgbui 24 1 The the DT cord-289926-y1rjgbui 24 2 sequence sequence NN cord-289926-y1rjgbui 24 3 similarity similarity NN cord-289926-y1rjgbui 24 4 between between IN cord-289926-y1rjgbui 24 5 the the DT cord-289926-y1rjgbui 24 6 central central JJ cord-289926-y1rjgbui 24 7 domain domain NN cord-289926-y1rjgbui 24 8 of of IN cord-289926-y1rjgbui 24 9 HDAg hdag NN cord-289926-y1rjgbui 24 10 and and CC cord-289926-y1rjgbui 24 11 the the DT cord-289926-y1rjgbui 24 12 HMG HMG NNP cord-289926-y1rjgbui 24 13 ( ( -LRB- cord-289926-y1rjgbui 24 14 High High NNP cord-289926-y1rjgbui 24 15 Mobility Mobility NNP cord-289926-y1rjgbui 24 16 Group Group NNP cord-289926-y1rjgbui 24 17 ) ) -RRB- cord-289926-y1rjgbui 24 18 box box NN cord-289926-y1rjgbui 24 19 of of IN cord-289926-y1rjgbui 24 20 the the DT cord-289926-y1rjgbui 24 21 SRY SRY NNP cord-289926-y1rjgbui 24 22 gene gene NN cord-289926-y1rjgbui 24 23 suggests suggest VBZ cord-289926-y1rjgbui 24 24 that that IN cord-289926-y1rjgbui 24 25 SRY SRY NNP cord-289926-y1rjgbui 24 26 may may MD cord-289926-y1rjgbui 24 27 be be VB cord-289926-y1rjgbui 24 28 a a DT cord-289926-y1rjgbui 24 29 cellular cellular JJ cord-289926-y1rjgbui 24 30 cognate cognate NN cord-289926-y1rjgbui 24 31 of of IN cord-289926-y1rjgbui 24 32 HDAg HDAg NNS cord-289926-y1rjgbui 24 33 . . . cord-289926-y1rjgbui 25 1 Another another DT cord-289926-y1rjgbui 25 2 candidate candidate NN cord-289926-y1rjgbui 25 3 for for IN cord-289926-y1rjgbui 25 4 the the DT cord-289926-y1rjgbui 25 5 ' ' `` cord-289926-y1rjgbui 25 6 captured capture VBN cord-289926-y1rjgbui 25 7 ' ' '' cord-289926-y1rjgbui 25 8 cellular cellular JJ cord-289926-y1rjgbui 25 9 RNA RNA NNP cord-289926-y1rjgbui 25 10 was be VBD cord-289926-y1rjgbui 25 11 recently recently RB cord-289926-y1rjgbui 25 12 proposed propose VBN cord-289926-y1rjgbui 25 13 : : : cord-289926-y1rjgbui 25 14 a a DT cord-289926-y1rjgbui 25 15 202 202 CD cord-289926-y1rjgbui 25 16 residue residue NN cord-289926-y1rjgbui 25 17 cellular cellular JJ cord-289926-y1rjgbui 25 18 protein protein NN cord-289926-y1rjgbui 25 19 referred refer VBD cord-289926-y1rjgbui 25 20 to to IN cord-289926-y1rjgbui 25 21 as as IN cord-289926-y1rjgbui 25 22 DIPA DIPA NNP cord-289926-y1rjgbui 25 23 ( ( -LRB- cord-289926-y1rjgbui 25 24 delta delta NNP cord-289926-y1rjgbui 25 25 interacting interact VBG cord-289926-y1rjgbui 25 26 protein protein NN cord-289926-y1rjgbui 25 27 A A NNP cord-289926-y1rjgbui 25 28 ) ) -RRB- cord-289926-y1rjgbui 25 29 was be VBD cord-289926-y1rjgbui 25 30 identified identify VBN cord-289926-y1rjgbui 25 31 by by IN cord-289926-y1rjgbui 25 32 co co NN cord-289926-y1rjgbui 25 33 - - NN cord-289926-y1rjgbui 25 34 immunoprecipitation immunoprecipitation JJ cord-289926-y1rjgbui 25 35 with with IN cord-289926-y1rjgbui 25 36 HDAg HDAg NNS cord-289926-y1rjgbui 25 37 and and CC cord-289926-y1rjgbui 25 38 by by IN cord-289926-y1rjgbui 25 39 its -PRON- PRP$ cord-289926-y1rjgbui 25 40 in in IN cord-289926-y1rjgbui 25 41 vivo vivo NN cord-289926-y1rjgbui 25 42 ability ability NN cord-289926-y1rjgbui 25 43 to to TO cord-289926-y1rjgbui 25 44 inhibit inhibit VB cord-289926-y1rjgbui 25 45 viral viral JJ cord-289926-y1rjgbui 25 46 replication replication NN cord-289926-y1rjgbui 25 47 [ [ -LRB- cord-289926-y1rjgbui 25 48 5 5 CD cord-289926-y1rjgbui 25 49 ] ] -RRB- cord-289926-y1rjgbui 25 50 . . . cord-289926-y1rjgbui 26 1 Our -PRON- PRP$ cord-289926-y1rjgbui 26 2 analysis analysis NN cord-289926-y1rjgbui 26 3 shows show VBZ cord-289926-y1rjgbui 26 4 that that IN cord-289926-y1rjgbui 26 5 the the DT cord-289926-y1rjgbui 26 6 level level NN cord-289926-y1rjgbui 26 7 of of IN cord-289926-y1rjgbui 26 8 similarity similarity NN cord-289926-y1rjgbui 26 9 between between IN cord-289926-y1rjgbui 26 10 HDAg HDAg NNS cord-289926-y1rjgbui 26 11 and and CC cord-289926-y1rjgbui 26 12 DIPA DIPA NNP cord-289926-y1rjgbui 26 13 is be VBZ cord-289926-y1rjgbui 26 14 within within IN cord-289926-y1rjgbui 26 15 noise noise NN cord-289926-y1rjgbui 26 16 level level NN cord-289926-y1rjgbui 26 17 ; ; : cord-289926-y1rjgbui 26 18 the the DT cord-289926-y1rjgbui 26 19 similarity similarity NN cord-289926-y1rjgbui 26 20 is be VBZ cord-289926-y1rjgbui 26 21 likely likely JJ cord-289926-y1rjgbui 26 22 to to TO cord-289926-y1rjgbui 26 23 be be VB cord-289926-y1rjgbui 26 24 due due JJ cord-289926-y1rjgbui 26 25 to to IN cord-289926-y1rjgbui 26 26 compositional compositional JJ cord-289926-y1rjgbui 26 27 biases bias NNS cord-289926-y1rjgbui 26 28 found find VBN cord-289926-y1rjgbui 26 29 in in IN cord-289926-y1rjgbui 26 30 motifs motif NNS cord-289926-y1rjgbui 26 31 consisting consist VBG cord-289926-y1rjgbui 26 32 of of IN cord-289926-y1rjgbui 26 33 arginine arginine NN cord-289926-y1rjgbui 26 34 - - HYPH cord-289926-y1rjgbui 26 35 rich rich JJ cord-289926-y1rjgbui 26 36 regions region NNS cord-289926-y1rjgbui 26 37 and and CC cord-289926-y1rjgbui 26 38 leucine leucine NN cord-289926-y1rjgbui 26 39 zippers zipper NNS cord-289926-y1rjgbui 26 40 ( ( -LRB- cord-289926-y1rjgbui 26 41 bZIP bzip CD cord-289926-y1rjgbui 26 42 motifs motif NNS cord-289926-y1rjgbui 26 43 ) ) -RRB- cord-289926-y1rjgbui 26 44 . . . cord-289926-y1rjgbui 27 1 This this DT cord-289926-y1rjgbui 27 2 paper paper NN cord-289926-y1rjgbui 27 3 reports report VBZ cord-289926-y1rjgbui 27 4 the the DT cord-289926-y1rjgbui 27 5 results result NNS cord-289926-y1rjgbui 27 6 of of IN cord-289926-y1rjgbui 27 7 the the DT cord-289926-y1rjgbui 27 8 in in IN cord-289926-y1rjgbui 27 9 - - HYPH cord-289926-y1rjgbui 27 10 depth depth NN cord-289926-y1rjgbui 27 11 sequence sequence NN cord-289926-y1rjgbui 27 12 analysis analysis NN cord-289926-y1rjgbui 27 13 applied apply VBN cord-289926-y1rjgbui 27 14 to to IN cord-289926-y1rjgbui 27 15 the the DT cord-289926-y1rjgbui 27 16 sequence sequence NN cord-289926-y1rjgbui 27 17 of of IN cord-289926-y1rjgbui 27 18 HDV HDV NNP cord-289926-y1rjgbui 27 19 antigen antigen NN cord-289926-y1rjgbui 27 20 in in IN cord-289926-y1rjgbui 27 21 an an DT cord-289926-y1rjgbui 27 22 attempt attempt NN cord-289926-y1rjgbui 27 23 to to TO cord-289926-y1rjgbui 27 24 further further RB cord-289926-y1rjgbui 27 25 understand understand VB cord-289926-y1rjgbui 27 26 the the DT cord-289926-y1rjgbui 27 27 function function NN cord-289926-y1rjgbui 27 28 and and CC cord-289926-y1rjgbui 27 29 evolution evolution NN cord-289926-y1rjgbui 27 30 of of IN cord-289926-y1rjgbui 27 31 hepatitis hepatitis NN cord-289926-y1rjgbui 27 32 delta delta NNP cord-289926-y1rjgbui 27 33 virus virus NN cord-289926-y1rjgbui 27 34 -a -a : cord-289926-y1rjgbui 27 35 unique unique JJ cord-289926-y1rjgbui 27 36 entity entity NN cord-289926-y1rjgbui 27 37 in in IN cord-289926-y1rjgbui 27 38 the the DT cord-289926-y1rjgbui 27 39 world world NN cord-289926-y1rjgbui 27 40 of of IN cord-289926-y1rjgbui 27 41 animal animal NN cord-289926-y1rjgbui 27 42 RNA RNA NNP cord-289926-y1rjgbui 27 43 viruses virus NNS cord-289926-y1rjgbui 27 44 . . . cord-289926-y1rjgbui 28 1 Sequence sequence NN cord-289926-y1rjgbui 28 2 alignments alignment NNS cord-289926-y1rjgbui 28 3 were be VBD cord-289926-y1rjgbui 28 4 performed perform VBN cord-289926-y1rjgbui 28 5 using use VBG cord-289926-y1rjgbui 28 6 programs program NNS cord-289926-y1rjgbui 28 7 from from IN cord-289926-y1rjgbui 28 8 the the DT cord-289926-y1rjgbui 28 9 GCG GCG NNP cord-289926-y1rjgbui 28 10 Wisconsin Wisconsin NNP cord-289926-y1rjgbui 28 11 Package Package NNP cord-289926-y1rjgbui 28 12 version version NN cord-289926-y1rjgbui 28 13 8 8 CD cord-289926-y1rjgbui 28 14 . . . cord-289926-y1rjgbui 29 1 1-UNIX 1-unix LS cord-289926-y1rjgbui 29 2 ( ( -LRB- cord-289926-y1rjgbui 29 3 1995 1995 CD cord-289926-y1rjgbui 29 4 ) ) -RRB- cord-289926-y1rjgbui 29 5 . . . cord-289926-y1rjgbui 30 1 For for IN cord-289926-y1rjgbui 30 2 multiple multiple JJ cord-289926-y1rjgbui 30 3 sequence sequence NN cord-289926-y1rjgbui 30 4 alignments alignment NNS cord-289926-y1rjgbui 30 5 , , , cord-289926-y1rjgbui 30 6 the the DT cord-289926-y1rjgbui 30 7 PILEUP PILEUP NNP cord-289926-y1rjgbui 30 8 program program NN cord-289926-y1rjgbui 30 9 ( ( -LRB- cord-289926-y1rjgbui 30 10 based base VBN cord-289926-y1rjgbui 30 11 on on IN cord-289926-y1rjgbui 30 12 a a DT cord-289926-y1rjgbui 30 13 simplified simplified JJ cord-289926-y1rjgbui 30 14 version version NN cord-289926-y1rjgbui 30 15 of of IN cord-289926-y1rjgbui 30 16 the the DT cord-289926-y1rjgbui 30 17 progressive progressive JJ cord-289926-y1rjgbui 30 18 alignment alignment NN cord-289926-y1rjgbui 30 19 method method NN cord-289926-y1rjgbui 30 20 of of IN cord-289926-y1rjgbui 30 21 Feng Feng NNP cord-289926-y1rjgbui 30 22 and and CC cord-289926-y1rjgbui 30 23 Doolittle Doolittle NNP cord-289926-y1rjgbui 30 24 ) ) -RRB- cord-289926-y1rjgbui 30 25 [ [ -LRB- cord-289926-y1rjgbui 30 26 20 20 CD cord-289926-y1rjgbui 30 27 ] ] -RRB- cord-289926-y1rjgbui 30 28 under under IN cord-289926-y1rjgbui 30 29 default default NN cord-289926-y1rjgbui 30 30 conditions condition NNS cord-289926-y1rjgbui 30 31 ( ( -LRB- cord-289926-y1rjgbui 30 32 GapOpen=3.0 GapOpen=3.0 NNP cord-289926-y1rjgbui 30 33 , , , cord-289926-y1rjgbui 30 34 GapExtend=0.1 GapExtend=0.1 NNP cord-289926-y1rjgbui 30 35 ) ) -RRB- cord-289926-y1rjgbui 30 36 was be VBD cord-289926-y1rjgbui 30 37 applied apply VBN cord-289926-y1rjgbui 30 38 . . . cord-289926-y1rjgbui 31 1 The the DT cord-289926-y1rjgbui 31 2 GAP gap NN cord-289926-y1rjgbui 31 3 program program NN cord-289926-y1rjgbui 31 4 , , , cord-289926-y1rjgbui 31 5 based base VBN cord-289926-y1rjgbui 31 6 on on IN cord-289926-y1rjgbui 31 7 the the DT cord-289926-y1rjgbui 31 8 global global JJ cord-289926-y1rjgbui 31 9 alignment alignment NN cord-289926-y1rjgbui 31 10 algorithm algorithm NN cord-289926-y1rjgbui 31 11 of of IN cord-289926-y1rjgbui 31 12 Needleman Needleman NNP cord-289926-y1rjgbui 31 13 and and CC cord-289926-y1rjgbui 31 14 Wunsch Wunsch NNP cord-289926-y1rjgbui 31 15 [ [ -LRB- cord-289926-y1rjgbui 31 16 35 35 CD cord-289926-y1rjgbui 31 17 ] ] -RRB- cord-289926-y1rjgbui 31 18 was be VBD cord-289926-y1rjgbui 31 19 used use VBN cord-289926-y1rjgbui 31 20 for for IN cord-289926-y1rjgbui 31 21 alignment alignment NN cord-289926-y1rjgbui 31 22 of of IN cord-289926-y1rjgbui 31 23 sequence sequence NN cord-289926-y1rjgbui 31 24 pairs pair NNS cord-289926-y1rjgbui 31 25 . . . cord-289926-y1rjgbui 32 1 The the DT cord-289926-y1rjgbui 32 2 best well RBS cord-289926-y1rjgbui 32 3 matched match VBN cord-289926-y1rjgbui 32 4 subsequences subsequence NNS cord-289926-y1rjgbui 32 5 of of IN cord-289926-y1rjgbui 32 6 SRY SRY NNP cord-289926-y1rjgbui 32 7 , , , cord-289926-y1rjgbui 32 8 HDAg HDAg NNPS cord-289926-y1rjgbui 32 9 and and CC cord-289926-y1rjgbui 32 10 DIPA DIPA NNP cord-289926-y1rjgbui 32 11 were be VBD cord-289926-y1rjgbui 32 12 detected detect VBN cord-289926-y1rjgbui 32 13 by by IN cord-289926-y1rjgbui 32 14 visual visual JJ cord-289926-y1rjgbui 32 15 inspection inspection NN cord-289926-y1rjgbui 32 16 ; ; : cord-289926-y1rjgbui 32 17 alignments alignment NNS cord-289926-y1rjgbui 32 18 of of IN cord-289926-y1rjgbui 32 19 these these DT cord-289926-y1rjgbui 32 20 regions region NNS cord-289926-y1rjgbui 32 21 are be VBP cord-289926-y1rjgbui 32 22 referred refer VBN cord-289926-y1rjgbui 32 23 to to IN cord-289926-y1rjgbui 32 24 as as IN cord-289926-y1rjgbui 32 25 partial partial JJ cord-289926-y1rjgbui 32 26 alignments alignment NNS cord-289926-y1rjgbui 32 27 throughout throughout IN cord-289926-y1rjgbui 32 28 this this DT cord-289926-y1rjgbui 32 29 paper paper NN cord-289926-y1rjgbui 32 30 . . . cord-289926-y1rjgbui 33 1 The the DT cord-289926-y1rjgbui 33 2 partial partial JJ cord-289926-y1rjgbui 33 3 alignments alignment NNS cord-289926-y1rjgbui 33 4 were be VBD cord-289926-y1rjgbui 33 5 constructed construct VBN cord-289926-y1rjgbui 33 6 by by IN cord-289926-y1rjgbui 33 7 aligning align VBG cord-289926-y1rjgbui 33 8 selected select VBN cord-289926-y1rjgbui 33 9 subsequences subsequence NNS cord-289926-y1rjgbui 33 10 using use VBG cord-289926-y1rjgbui 33 11 the the DT cord-289926-y1rjgbui 33 12 GAP GAP NNP cord-289926-y1rjgbui 33 13 program program NN cord-289926-y1rjgbui 33 14 . . . cord-289926-y1rjgbui 34 1 The the DT cord-289926-y1rjgbui 34 2 comparison comparison NN cord-289926-y1rjgbui 34 3 matrix matrix NN cord-289926-y1rjgbui 34 4 PAM150 PAM150 NNP cord-289926-y1rjgbui 34 5 [ [ -LRB- cord-289926-y1rjgbui 34 6 12 12 CD cord-289926-y1rjgbui 34 7 ] ] -RRB- cord-289926-y1rjgbui 34 8 was be VBD cord-289926-y1rjgbui 34 9 used use VBN cord-289926-y1rjgbui 34 10 for for IN cord-289926-y1rjgbui 34 11 scoring score VBG cord-289926-y1rjgbui 34 12 amino amino NN cord-289926-y1rjgbui 34 13 acid acid NN cord-289926-y1rjgbui 34 14 residue residue NN cord-289926-y1rjgbui 34 15 similarities similarity NNS cord-289926-y1rjgbui 34 16 . . . cord-289926-y1rjgbui 35 1 Gap gap NN cord-289926-y1rjgbui 35 2 opening opening NN cord-289926-y1rjgbui 35 3 and and CC cord-289926-y1rjgbui 35 4 gap gap NN cord-289926-y1rjgbui 35 5 extension extension NN cord-289926-y1rjgbui 35 6 penalties penalty NNS cord-289926-y1rjgbui 35 7 were be VBD cord-289926-y1rjgbui 35 8 varied varied JJ cord-289926-y1rjgbui 35 9 and and CC cord-289926-y1rjgbui 35 10 are be VBP cord-289926-y1rjgbui 35 11 specified specify VBN cord-289926-y1rjgbui 35 12 for for IN cord-289926-y1rjgbui 35 13 each each DT cord-289926-y1rjgbui 35 14 alignment alignment NN cord-289926-y1rjgbui 35 15 . . . cord-289926-y1rjgbui 36 1 Monte Monte NNP cord-289926-y1rjgbui 36 2 Carlo Carlo NNP cord-289926-y1rjgbui 36 3 evaluation evaluation NN cord-289926-y1rjgbui 36 4 of of IN cord-289926-y1rjgbui 36 5 sequence sequence NN cord-289926-y1rjgbui 36 6 alignments alignment NNS cord-289926-y1rjgbui 36 7 was be VBD cord-289926-y1rjgbui 36 8 done do VBN cord-289926-y1rjgbui 36 9 using use VBG cord-289926-y1rjgbui 36 10 the the DT cord-289926-y1rjgbui 36 11 GAP GAP NNP cord-289926-y1rjgbui 36 12 program program NN cord-289926-y1rjgbui 36 13 with with IN cord-289926-y1rjgbui 36 14 the the DT cord-289926-y1rjgbui 36 15 option option NN cord-289926-y1rjgbui 36 16 ' ' `` cord-289926-y1rjgbui 36 17 -RANDOM=10000 -random=10000 UH cord-289926-y1rjgbui 36 18 ' ' '' cord-289926-y1rjgbui 36 19 . . . cord-289926-y1rjgbui 37 1 This this DT cord-289926-y1rjgbui 37 2 evaluation evaluation NN cord-289926-y1rjgbui 37 3 process process NN cord-289926-y1rjgbui 37 4 consists consist VBZ cord-289926-y1rjgbui 37 5 of of IN cord-289926-y1rjgbui 37 6 randomizing randomize VBG cord-289926-y1rjgbui 37 7 the the DT cord-289926-y1rjgbui 37 8 first first JJ cord-289926-y1rjgbui 37 9 sequence sequence NN cord-289926-y1rjgbui 37 10 and and CC cord-289926-y1rjgbui 37 11 realigning realign VBG cord-289926-y1rjgbui 37 12 it -PRON- PRP cord-289926-y1rjgbui 37 13 to to IN cord-289926-y1rjgbui 37 14 the the DT cord-289926-y1rjgbui 37 15 second second JJ cord-289926-y1rjgbui 37 16 sequence sequence NN cord-289926-y1rjgbui 37 17 10,000 10,000 CD cord-289926-y1rjgbui 37 18 times time NNS cord-289926-y1rjgbui 37 19 , , , cord-289926-y1rjgbui 37 20 each each DT cord-289926-y1rjgbui 37 21 time time NN cord-289926-y1rjgbui 37 22 calculating calculate VBG cord-289926-y1rjgbui 37 23 the the DT cord-289926-y1rjgbui 37 24 alignment alignment NN cord-289926-y1rjgbui 37 25 score score NN cord-289926-y1rjgbui 37 26 . . . cord-289926-y1rjgbui 38 1 The the DT cord-289926-y1rjgbui 38 2 average average JJ cord-289926-y1rjgbui 38 3 and and CC cord-289926-y1rjgbui 38 4 standard standard JJ cord-289926-y1rjgbui 38 5 deviation deviation NN cord-289926-y1rjgbui 38 6 of of IN cord-289926-y1rjgbui 38 7 10,000 10,000 CD cord-289926-y1rjgbui 38 8 alignments alignment NNS cord-289926-y1rjgbui 38 9 of of IN cord-289926-y1rjgbui 38 10 randomized randomized JJ cord-289926-y1rjgbui 38 11 sequences sequence NNS cord-289926-y1rjgbui 38 12 were be VBD cord-289926-y1rjgbui 38 13 then then RB cord-289926-y1rjgbui 38 14 used use VBN cord-289926-y1rjgbui 38 15 to to TO cord-289926-y1rjgbui 38 16 calculate calculate VB cord-289926-y1rjgbui 38 17 the the DT cord-289926-y1rjgbui 38 18 Z z NN cord-289926-y1rjgbui 38 19 score score NN cord-289926-y1rjgbui 38 20 1 1 CD cord-289926-y1rjgbui 38 21 for for IN cord-289926-y1rjgbui 38 22 the the DT cord-289926-y1rjgbui 38 23 original original JJ cord-289926-y1rjgbui 38 24 alignment alignment NN cord-289926-y1rjgbui 38 25 . . . cord-289926-y1rjgbui 39 1 The the DT cord-289926-y1rjgbui 39 2 SWISS swiss JJ cord-289926-y1rjgbui 39 3 - - HYPH cord-289926-y1rjgbui 39 4 PROT prot NN cord-289926-y1rjgbui 39 5 database database NN cord-289926-y1rjgbui 39 6 release release NN cord-289926-y1rjgbui 39 7 33 33 CD cord-289926-y1rjgbui 39 8 ( ( -LRB- cord-289926-y1rjgbui 39 9 2/96 2/96 CD cord-289926-y1rjgbui 39 10 ) ) -RRB- cord-289926-y1rjgbui 39 11 was be VBD cord-289926-y1rjgbui 39 12 used use VBN cord-289926-y1rjgbui 39 13 for for IN cord-289926-y1rjgbui 39 14 database database NN cord-289926-y1rjgbui 39 15 searches search NNS cord-289926-y1rjgbui 39 16 . . . cord-289926-y1rjgbui 40 1 Evolutionary evolutionary JJ cord-289926-y1rjgbui 40 2 profiles profile NNS cord-289926-y1rjgbui 40 3 [ [ -LRB- cord-289926-y1rjgbui 40 4 27 27 CD cord-289926-y1rjgbui 40 5 ] ] -RRB- cord-289926-y1rjgbui 40 6 were be VBD cord-289926-y1rjgbui 40 7 constructed construct VBN cord-289926-y1rjgbui 40 8 from from IN cord-289926-y1rjgbui 40 9 groups group NNS cord-289926-y1rjgbui 40 10 of of IN cord-289926-y1rjgbui 40 11 sequences sequence NNS cord-289926-y1rjgbui 40 12 aligned align VBN cord-289926-y1rjgbui 40 13 with with IN cord-289926-y1rjgbui 40 14 the the DT cord-289926-y1rjgbui 40 15 PILEUP PILEUP NNP cord-289926-y1rjgbui 40 16 program program NN cord-289926-y1rjgbui 40 17 . . . cord-289926-y1rjgbui 41 1 A a DT cord-289926-y1rjgbui 41 2 profile profile NN cord-289926-y1rjgbui 41 3 is be VBZ cord-289926-y1rjgbui 41 4 a a DT cord-289926-y1rjgbui 41 5 two two CD cord-289926-y1rjgbui 41 6 - - HYPH cord-289926-y1rjgbui 41 7 dimensional dimensional JJ cord-289926-y1rjgbui 41 8 weight weight NN cord-289926-y1rjgbui 41 9 matrix matrix NN cord-289926-y1rjgbui 41 10 that that WDT cord-289926-y1rjgbui 41 11 describes describe VBZ cord-289926-y1rjgbui 41 12 the the DT cord-289926-y1rjgbui 41 13 alignment alignment NN cord-289926-y1rjgbui 41 14 of of IN cord-289926-y1rjgbui 41 15 a a DT cord-289926-y1rjgbui 41 16 group group NN cord-289926-y1rjgbui 41 17 of of IN cord-289926-y1rjgbui 41 18 sequences sequence NNS cord-289926-y1rjgbui 41 19 . . . cord-289926-y1rjgbui 42 1 Each each DT cord-289926-y1rjgbui 42 2 row row NN cord-289926-y1rjgbui 42 3 of of IN cord-289926-y1rjgbui 42 4 a a DT cord-289926-y1rjgbui 42 5 profile profile NN cord-289926-y1rjgbui 42 6 describes describe VBZ cord-289926-y1rjgbui 42 7 a a DT cord-289926-y1rjgbui 42 8 single single JJ cord-289926-y1rjgbui 42 9 position position NN cord-289926-y1rjgbui 42 10 in in IN cord-289926-y1rjgbui 42 11 the the DT cord-289926-y1rjgbui 42 12 alignment alignment NN cord-289926-y1rjgbui 42 13 ; ; : cord-289926-y1rjgbui 42 14 its -PRON- PRP$ cord-289926-y1rjgbui 42 15 20 20 CD cord-289926-y1rjgbui 42 16 values value NNS cord-289926-y1rjgbui 42 17 estimate estimate VBP cord-289926-y1rjgbui 42 18 the the DT cord-289926-y1rjgbui 42 19 likelihood likelihood NN cord-289926-y1rjgbui 42 20 that that IN cord-289926-y1rjgbui 42 21 each each DT cord-289926-y1rjgbui 42 22 of of IN cord-289926-y1rjgbui 42 23 the the DT cord-289926-y1rjgbui 42 24 20 20 CD cord-289926-y1rjgbui 42 25 possible possible JJ cord-289926-y1rjgbui 42 26 amino amino NN cord-289926-y1rjgbui 42 27 acid acid NN cord-289926-y1rjgbui 42 28 residues residue NNS cord-289926-y1rjgbui 42 29 occurs occur VBZ cord-289926-y1rjgbui 42 30 at at IN cord-289926-y1rjgbui 42 31 this this DT cord-289926-y1rjgbui 42 32 position position NN cord-289926-y1rjgbui 42 33 in in IN cord-289926-y1rjgbui 42 34 the the DT cord-289926-y1rjgbui 42 35 alignment alignment NN cord-289926-y1rjgbui 42 36 . . . cord-289926-y1rjgbui 43 1 Two two CD cord-289926-y1rjgbui 43 2 additional additional JJ cord-289926-y1rjgbui 43 3 values value NNS cord-289926-y1rjgbui 43 4 in in IN cord-289926-y1rjgbui 43 5 each each DT cord-289926-y1rjgbui 43 6 row row NN cord-289926-y1rjgbui 43 7 represent represent VBP cord-289926-y1rjgbui 43 8 the the DT cord-289926-y1rjgbui 43 9 position position NN cord-289926-y1rjgbui 43 10 - - HYPH cord-289926-y1rjgbui 43 11 specific specific JJ cord-289926-y1rjgbui 43 12 likelihood likelihood NN cord-289926-y1rjgbui 43 13 of of IN cord-289926-y1rjgbui 43 14 gap gap NN cord-289926-y1rjgbui 43 15 initiation initiation NN cord-289926-y1rjgbui 43 16 and and CC cord-289926-y1rjgbui 43 17 extension extension NN cord-289926-y1rjgbui 43 18 . . . cord-289926-y1rjgbui 44 1 Evolutionary evolutionary JJ cord-289926-y1rjgbui 44 2 profiles profile NNS cord-289926-y1rjgbui 44 3 improve improve VBP cord-289926-y1rjgbui 44 4 the the DT cord-289926-y1rjgbui 44 5 description description NN cord-289926-y1rjgbui 44 6 of of IN cord-289926-y1rjgbui 44 7 multiple multiple JJ cord-289926-y1rjgbui 44 8 sequence sequence NN cord-289926-y1rjgbui 44 9 alignments alignment NNS cord-289926-y1rjgbui 44 10 by by IN cord-289926-y1rjgbui 44 11 modeling model VBG cord-289926-y1rjgbui 44 12 varying vary VBG cord-289926-y1rjgbui 44 13 rates rate NNS cord-289926-y1rjgbui 44 14 of of IN cord-289926-y1rjgbui 44 15 sequence sequence NN cord-289926-y1rjgbui 44 16 change change NN cord-289926-y1rjgbui 44 17 at at IN cord-289926-y1rjgbui 44 18 each each DT cord-289926-y1rjgbui 44 19 position position NN cord-289926-y1rjgbui 44 20 in in IN cord-289926-y1rjgbui 44 21 the the DT cord-289926-y1rjgbui 44 22 sequences sequence NNS cord-289926-y1rjgbui 44 23 : : : cord-289926-y1rjgbui 44 24 each each DT cord-289926-y1rjgbui 44 25 position position NN cord-289926-y1rjgbui 44 26 is be VBZ cord-289926-y1rjgbui 44 27 modeled model VBN cord-289926-y1rjgbui 44 28 using use VBG cord-289926-y1rjgbui 44 29 the the DT cord-289926-y1rjgbui 44 30 most most RBS cord-289926-y1rjgbui 44 31 appropriate appropriate JJ cord-289926-y1rjgbui 44 32 scoring scoring NN cord-289926-y1rjgbui 44 33 matrix matrix NN cord-289926-y1rjgbui 44 34 to to TO cord-289926-y1rjgbui 44 35 reflect reflect VB cord-289926-y1rjgbui 44 36 its -PRON- PRP$ cord-289926-y1rjgbui 44 37 rate rate NN cord-289926-y1rjgbui 44 38 of of IN cord-289926-y1rjgbui 44 39 change change NN cord-289926-y1rjgbui 44 40 . . . cord-289926-y1rjgbui 45 1 Sequence sequence NN cord-289926-y1rjgbui 45 2 weighting weighting NN cord-289926-y1rjgbui 45 3 , , , cord-289926-y1rjgbui 45 4 based base VBN cord-289926-y1rjgbui 45 5 on on IN cord-289926-y1rjgbui 45 6 a a DT cord-289926-y1rjgbui 45 7 modification modification NN cord-289926-y1rjgbui 45 8 of of IN cord-289926-y1rjgbui 45 9 Felsenstein Felsenstein NNP cord-289926-y1rjgbui 45 10 's 's POS cord-289926-y1rjgbui 45 11 method method NN cord-289926-y1rjgbui 45 12 [ [ -LRB- cord-289926-y1rjgbui 45 13 19 19 CD cord-289926-y1rjgbui 45 14 ] ] -RRB- cord-289926-y1rjgbui 45 15 , , , cord-289926-y1rjgbui 45 16 was be VBD cord-289926-y1rjgbui 45 17 performed perform VBN cord-289926-y1rjgbui 45 18 prior prior RB cord-289926-y1rjgbui 45 19 to to IN cord-289926-y1rjgbui 45 20 profile profile JJ cord-289926-y1rjgbui 45 21 construction construction NN cord-289926-y1rjgbui 45 22 , , , cord-289926-y1rjgbui 45 23 so so IN cord-289926-y1rjgbui 45 24 that that IN cord-289926-y1rjgbui 45 25 the the DT cord-289926-y1rjgbui 45 26 contribution contribution NN cord-289926-y1rjgbui 45 27 of of IN cord-289926-y1rjgbui 45 28 each each DT cord-289926-y1rjgbui 45 29 sequence sequence NN cord-289926-y1rjgbui 45 30 to to IN cord-289926-y1rjgbui 45 31 the the DT cord-289926-y1rjgbui 45 32 evolutionary evolutionary JJ cord-289926-y1rjgbui 45 33 profile profile NN cord-289926-y1rjgbui 45 34 is be VBZ cord-289926-y1rjgbui 45 35 proportional proportional JJ cord-289926-y1rjgbui 45 36 to to IN cord-289926-y1rjgbui 45 37 the the DT cord-289926-y1rjgbui 45 38 amount amount NN cord-289926-y1rjgbui 45 39 of of IN cord-289926-y1rjgbui 45 40 unique unique JJ cord-289926-y1rjgbui 45 41 information information NN cord-289926-y1rjgbui 45 42 it -PRON- PRP cord-289926-y1rjgbui 45 43 contributes contribute VBZ cord-289926-y1rjgbui 45 44 to to IN cord-289926-y1rjgbui 45 45 the the DT cord-289926-y1rjgbui 45 46 multiple multiple JJ cord-289926-y1rjgbui 45 47 alignment alignment NN cord-289926-y1rjgbui 45 48 . . . cord-289926-y1rjgbui 46 1 Structure structure NN cord-289926-y1rjgbui 46 2 - - HYPH cord-289926-y1rjgbui 46 3 based base VBN cord-289926-y1rjgbui 46 4 profiles profile NNS cord-289926-y1rjgbui 46 5 ( ( -LRB- cord-289926-y1rjgbui 46 6 to to TO cord-289926-y1rjgbui 46 7 be be VB cord-289926-y1rjgbui 46 8 described describe VBN cord-289926-y1rjgbui 46 9 elsewhere elsewhere RB cord-289926-y1rjgbui 46 10 ) ) -RRB- cord-289926-y1rjgbui 46 11 are be VBP cord-289926-y1rjgbui 46 12 constructed construct VBN cord-289926-y1rjgbui 46 13 using use VBG cord-289926-y1rjgbui 46 14 scoring score VBG cord-289926-y1rjgbui 46 15 matrices matrix NNS cord-289926-y1rjgbui 46 16 based base VBN cord-289926-y1rjgbui 46 17 on on IN cord-289926-y1rjgbui 46 18 secondary secondary JJ cord-289926-y1rjgbui 46 19 structure structure NN cord-289926-y1rjgbui 46 20 information information NN cord-289926-y1rjgbui 46 21 . . . cord-289926-y1rjgbui 47 1 Each each DT cord-289926-y1rjgbui 47 2 position position NN cord-289926-y1rjgbui 47 3 in in IN cord-289926-y1rjgbui 47 4 the the DT cord-289926-y1rjgbui 47 5 alignment alignment NN cord-289926-y1rjgbui 47 6 is be VBZ cord-289926-y1rjgbui 47 7 described describe VBN cord-289926-y1rjgbui 47 8 as as IN cord-289926-y1rjgbui 47 9 a a DT cord-289926-y1rjgbui 47 10 mixture mixture NN cord-289926-y1rjgbui 47 11 of of IN cord-289926-y1rjgbui 47 12 four four CD cord-289926-y1rjgbui 47 13 distributions distribution NNS cord-289926-y1rjgbui 47 14 -one -one CD cord-289926-y1rjgbui 47 15 for for IN cord-289926-y1rjgbui 47 16 each each DT cord-289926-y1rjgbui 47 17 of of IN cord-289926-y1rjgbui 47 18 the the DT cord-289926-y1rjgbui 47 19 secondary secondary JJ cord-289926-y1rjgbui 47 20 structures structure NNS cord-289926-y1rjgbui 47 21 ( ( -LRB- cord-289926-y1rjgbui 47 22 helix helix NN cord-289926-y1rjgbui 47 23 , , , cord-289926-y1rjgbui 47 24 sheet sheet NN cord-289926-y1rjgbui 47 25 , , , cord-289926-y1rjgbui 47 26 turn turn VB cord-289926-y1rjgbui 47 27 and and CC cord-289926-y1rjgbui 47 28 coil coil NN cord-289926-y1rjgbui 47 29 ) ) -RRB- cord-289926-y1rjgbui 47 30 . . . cord-289926-y1rjgbui 48 1 Each each DT cord-289926-y1rjgbui 48 2 distribution distribution NN cord-289926-y1rjgbui 48 3 is be VBZ cord-289926-y1rjgbui 48 4 weighted weight VBN cord-289926-y1rjgbui 48 5 by by IN cord-289926-y1rjgbui 48 6 the the DT cord-289926-y1rjgbui 48 7 likelihood likelihood NN cord-289926-y1rjgbui 48 8 of of IN cord-289926-y1rjgbui 48 9 the the DT cord-289926-y1rjgbui 48 10 observed observed JJ cord-289926-y1rjgbui 48 11 residue residue NN cord-289926-y1rjgbui 48 12 distribution distribution NN cord-289926-y1rjgbui 48 13 at at IN cord-289926-y1rjgbui 48 14 a a DT cord-289926-y1rjgbui 48 15 given give VBN cord-289926-y1rjgbui 48 16 position position NN cord-289926-y1rjgbui 48 17 being be VBG cord-289926-y1rjgbui 48 18 found find VBN cord-289926-y1rjgbui 48 19 in in IN cord-289926-y1rjgbui 48 20 a a DT cord-289926-y1rjgbui 48 21 specific specific JJ cord-289926-y1rjgbui 48 22 secondary secondary JJ cord-289926-y1rjgbui 48 23 structure structure NN cord-289926-y1rjgbui 48 24 . . . cord-289926-y1rjgbui 49 1 New new JJ cord-289926-y1rjgbui 49 2 sequences sequence NNS cord-289926-y1rjgbui 49 3 identified identify VBN cord-289926-y1rjgbui 49 4 during during IN cord-289926-y1rjgbui 49 5 the the DT cord-289926-y1rjgbui 49 6 database database NN cord-289926-y1rjgbui 49 7 search search NN cord-289926-y1rjgbui 49 8 with with IN cord-289926-y1rjgbui 49 9 the the DT cord-289926-y1rjgbui 49 10 profile profile NN cord-289926-y1rjgbui 49 11 of of IN cord-289926-y1rjgbui 49 12 the the DT cord-289926-y1rjgbui 49 13 HDAg HDAg NNP cord-289926-y1rjgbui 49 14 family family NN cord-289926-y1rjgbui 49 15 were be VBD cord-289926-y1rjgbui 49 16 then then RB cord-289926-y1rjgbui 49 17 re re VBN cord-289926-y1rjgbui 49 18 - - VBN cord-289926-y1rjgbui 49 19 aligned align VBN cord-289926-y1rjgbui 49 20 to to IN cord-289926-y1rjgbui 49 21 this this DT cord-289926-y1rjgbui 49 22 profile profile NN cord-289926-y1rjgbui 49 23 with with IN cord-289926-y1rjgbui 49 24 the the DT cord-289926-y1rjgbui 49 25 PROFILEGAP PROFILEGAP NNP cord-289926-y1rjgbui 49 26 program program NN cord-289926-y1rjgbui 49 27 using use VBG cord-289926-y1rjgbui 49 28 default default NN cord-289926-y1rjgbui 49 29 gap gap NN cord-289926-y1rjgbui 49 30 opening opening NN cord-289926-y1rjgbui 49 31 and and CC cord-289926-y1rjgbui 49 32 gap gap NN cord-289926-y1rjgbui 49 33 extension extension NN cord-289926-y1rjgbui 49 34 penalties penalty NNS cord-289926-y1rjgbui 49 35 ( ( -LRB- cord-289926-y1rjgbui 49 36 GapOpen=3.0 GapOpen=3.0 NNP cord-289926-y1rjgbui 49 37 , , , cord-289926-y1rjgbui 49 38 GapExtend=0.1 GapExtend=0.1 NNP cord-289926-y1rjgbui 49 39 ) ) -RRB- cord-289926-y1rjgbui 49 40 . . . cord-289926-y1rjgbui 50 1 The the DT cord-289926-y1rjgbui 50 2 Profilegap Profilegap NNP cord-289926-y1rjgbui 50 3 program program NN cord-289926-y1rjgbui 50 4 is be VBZ cord-289926-y1rjgbui 50 5 based base VBN cord-289926-y1rjgbui 50 6 on on IN cord-289926-y1rjgbui 50 7 an an DT cord-289926-y1rjgbui 50 8 extension extension NN cord-289926-y1rjgbui 50 9 of of IN cord-289926-y1rjgbui 50 10 the the DT cord-289926-y1rjgbui 50 11 Smith Smith NNP cord-289926-y1rjgbui 50 12 - - HYPH cord-289926-y1rjgbui 50 13 Waterman Waterman NNP cord-289926-y1rjgbui 50 14 local local JJ cord-289926-y1rjgbui 50 15 similarity similarity NN cord-289926-y1rjgbui 50 16 algorithm algorithm NN cord-289926-y1rjgbui 50 17 [ [ -LRB- cord-289926-y1rjgbui 50 18 26 26 CD cord-289926-y1rjgbui 50 19 , , , cord-289926-y1rjgbui 50 20 42 42 CD cord-289926-y1rjgbui 50 21 ] ] -RRB- cord-289926-y1rjgbui 50 22 . . . cord-289926-y1rjgbui 51 1 The the DT cord-289926-y1rjgbui 51 2 GCG GCG NNP cord-289926-y1rjgbui 51 3 Package Package NNP cord-289926-y1rjgbui 51 4 FRAMESEARCH FRAMESEARCH NNP cord-289926-y1rjgbui 51 5 program program NN cord-289926-y1rjgbui 51 6 was be VBD cord-289926-y1rjgbui 51 7 used use VBN cord-289926-y1rjgbui 51 8 to to TO cord-289926-y1rjgbui 51 9 search search VB cord-289926-y1rjgbui 51 10 for for IN cord-289926-y1rjgbui 51 11 sequencing sequencing NN cord-289926-y1rjgbui 51 12 errors error NNS cord-289926-y1rjgbui 51 13 and and CC cord-289926-y1rjgbui 51 14 potential potential JJ cord-289926-y1rjgbui 51 15 frameshifts frameshift NNS cord-289926-y1rjgbui 51 16 during during IN cord-289926-y1rjgbui 51 17 translation translation NN cord-289926-y1rjgbui 51 18 . . . cord-289926-y1rjgbui 52 1 Framesearch Framesearch NNP cord-289926-y1rjgbui 52 2 is be VBZ cord-289926-y1rjgbui 52 3 based base VBN cord-289926-y1rjgbui 52 4 on on IN cord-289926-y1rjgbui 52 5 a a DT cord-289926-y1rjgbui 52 6 local local JJ cord-289926-y1rjgbui 52 7 alignment alignment NN cord-289926-y1rjgbui 52 8 algorithm algorithm NN cord-289926-y1rjgbui 52 9 that that WDT cord-289926-y1rjgbui 52 10 allows allow VBZ cord-289926-y1rjgbui 52 11 introduction introduction NN cord-289926-y1rjgbui 52 12 of of IN cord-289926-y1rjgbui 52 13 the the DT cord-289926-y1rjgbui 52 14 gaps gap NNS cord-289926-y1rjgbui 52 15 and and CC cord-289926-y1rjgbui 52 16 shifting shift VBG cord-289926-y1rjgbui 52 17 of of IN cord-289926-y1rjgbui 52 18 the the DT cord-289926-y1rjgbui 52 19 reading reading NN cord-289926-y1rjgbui 52 20 frame frame NN cord-289926-y1rjgbui 52 21 . . . cord-289926-y1rjgbui 53 1 Framesearch Framesearch NNP cord-289926-y1rjgbui 53 2 was be VBD cord-289926-y1rjgbui 53 3 used use VBN cord-289926-y1rjgbui 53 4 under under IN cord-289926-y1rjgbui 53 5 the the DT cord-289926-y1rjgbui 53 6 following follow VBG cord-289926-y1rjgbui 53 7 conditions condition NNS cord-289926-y1rjgbui 53 8 : : : cord-289926-y1rjgbui 53 9 GapOpen=3.0 gapopen=3.0 ADD cord-289926-y1rjgbui 53 10 , , , cord-289926-y1rjgbui 53 11 GapExtend=0.5 gapextend=0.5 NN cord-289926-y1rjgbui 53 12 , , , cord-289926-y1rjgbui 53 13 scoring score VBG cord-289926-y1rjgbui 53 14 matrix matrix NN cord-289926-y1rjgbui 53 15 : : : cord-289926-y1rjgbui 53 16 PAM150 PAM150 NNP cord-289926-y1rjgbui 53 17 . . . cord-289926-y1rjgbui 54 1 PAM PAM NNP cord-289926-y1rjgbui 54 2 matrices matrix NNS cord-289926-y1rjgbui 54 3 at at IN cord-289926-y1rjgbui 54 4 distances distance NNS cord-289926-y1rjgbui 54 5 100 100 CD cord-289926-y1rjgbui 54 6 , , , cord-289926-y1rjgbui 54 7 150 150 CD cord-289926-y1rjgbui 54 8 , , , cord-289926-y1rjgbui 54 9 200 200 CD cord-289926-y1rjgbui 54 10 and and CC cord-289926-y1rjgbui 54 11 250 250 CD cord-289926-y1rjgbui 54 12 were be VBD cord-289926-y1rjgbui 54 13 tested test VBN cord-289926-y1rjgbui 54 14 [ [ -LRB- cord-289926-y1rjgbui 54 15 12 12 CD cord-289926-y1rjgbui 54 16 ] ] -RRB- cord-289926-y1rjgbui 54 17 . . . cord-289926-y1rjgbui 55 1 We -PRON- PRP cord-289926-y1rjgbui 55 2 found find VBD cord-289926-y1rjgbui 55 3 that that IN cord-289926-y1rjgbui 55 4 the the DT cord-289926-y1rjgbui 55 5 PAM150 pam150 JJ cord-289926-y1rjgbui 55 6 scoring scoring NN cord-289926-y1rjgbui 55 7 matrix matrix NN cord-289926-y1rjgbui 55 8 consistently consistently RB cord-289926-y1rjgbui 55 9 produced produce VBD cord-289926-y1rjgbui 55 10 alignments alignment NNS cord-289926-y1rjgbui 55 11 with with IN cord-289926-y1rjgbui 55 12 more more RBR cord-289926-y1rjgbui 55 13 significant significant JJ cord-289926-y1rjgbui 55 14 Z z NN cord-289926-y1rjgbui 55 15 scores score NNS cord-289926-y1rjgbui 55 16 . . . cord-289926-y1rjgbui 56 1 Thus thus RB cord-289926-y1rjgbui 56 2 PAM150 PAM150 NNP cord-289926-y1rjgbui 56 3 was be VBD cord-289926-y1rjgbui 56 4 used use VBN cord-289926-y1rjgbui 56 5 as as IN cord-289926-y1rjgbui 56 6 a a DT cord-289926-y1rjgbui 56 7 scoring scoring NN cord-289926-y1rjgbui 56 8 matrix matrix NN cord-289926-y1rjgbui 56 9 throughout throughout IN cord-289926-y1rjgbui 56 10 this this DT cord-289926-y1rjgbui 56 11 work work NN cord-289926-y1rjgbui 56 12 . . . cord-289926-y1rjgbui 57 1 P p NN cord-289926-y1rjgbui 57 2 - - HYPH cord-289926-y1rjgbui 57 3 values value NNS cord-289926-y1rjgbui 57 4 , , , cord-289926-y1rjgbui 57 5 the the DT cord-289926-y1rjgbui 57 6 probability probability NN cord-289926-y1rjgbui 57 7 of of IN cord-289926-y1rjgbui 57 8 achieving achieve VBG cord-289926-y1rjgbui 57 9 an an DT cord-289926-y1rjgbui 57 10 equal equal JJ cord-289926-y1rjgbui 57 11 or or CC cord-289926-y1rjgbui 57 12 better well JJR cord-289926-y1rjgbui 57 13 score score NN cord-289926-y1rjgbui 57 14 , , , cord-289926-y1rjgbui 57 15 for for IN cord-289926-y1rjgbui 57 16 the the DT cord-289926-y1rjgbui 57 17 best good JJS cord-289926-y1rjgbui 57 18 partial partial JJ cord-289926-y1rjgbui 57 19 alignments alignment NNS cord-289926-y1rjgbui 57 20 of of IN cord-289926-y1rjgbui 57 21 SRY sry NN cord-289926-y1rjgbui 57 22 - - HYPH cord-289926-y1rjgbui 57 23 HDAg HDAg NNS cord-289926-y1rjgbui 57 24 and and CC cord-289926-y1rjgbui 57 25 DIPA DIPA NNP cord-289926-y1rjgbui 57 26 - - HYPH cord-289926-y1rjgbui 57 27 HDAg HDAg NNP cord-289926-y1rjgbui 57 28 ( ( -LRB- cord-289926-y1rjgbui 57 29 Fig Fig NNP cord-289926-y1rjgbui 57 30 . . . cord-289926-y1rjgbui 57 31 2A 2a CD cord-289926-y1rjgbui 57 32 , , , cord-289926-y1rjgbui 57 33 C C NNP cord-289926-y1rjgbui 57 34 ) ) -RRB- cord-289926-y1rjgbui 57 35 were be VBD cord-289926-y1rjgbui 57 36 calculated calculate VBN cord-289926-y1rjgbui 57 37 by by IN cord-289926-y1rjgbui 57 38 the the DT cord-289926-y1rjgbui 57 39 Monte Monte NNP cord-289926-y1rjgbui 57 40 Carlo Carlo NNP cord-289926-y1rjgbui 57 41 procedure procedure NN cord-289926-y1rjgbui 57 42 described describe VBN cord-289926-y1rjgbui 57 43 above above RB cord-289926-y1rjgbui 57 44 ( ( -LRB- cord-289926-y1rjgbui 57 45 see see VB cord-289926-y1rjgbui 57 46 Sequence sequence NN cord-289926-y1rjgbui 57 47 alignments alignment NNS cord-289926-y1rjgbui 57 48 ) ) -RRB- cord-289926-y1rjgbui 57 49 . . . cord-289926-y1rjgbui 58 1 Randomly randomly RB cord-289926-y1rjgbui 58 2 generated generate VBN cord-289926-y1rjgbui 58 3 sequences sequence NNS cord-289926-y1rjgbui 58 4 with with IN cord-289926-y1rjgbui 58 5 the the DT cord-289926-y1rjgbui 58 6 same same JJ cord-289926-y1rjgbui 58 7 composition composition NN cord-289926-y1rjgbui 58 8 as as IN cord-289926-y1rjgbui 58 9 the the DT cord-289926-y1rjgbui 58 10 best good JJS cord-289926-y1rjgbui 58 11 locally locally RB cord-289926-y1rjgbui 58 12 matching match VBG cord-289926-y1rjgbui 58 13 segments segment NNS cord-289926-y1rjgbui 58 14 were be VBD cord-289926-y1rjgbui 58 15 compared compare VBN cord-289926-y1rjgbui 58 16 to to IN cord-289926-y1rjgbui 58 17 the the DT cord-289926-y1rjgbui 58 18 respective respective JJ cord-289926-y1rjgbui 58 19 query query NN cord-289926-y1rjgbui 58 20 sequence sequence NN cord-289926-y1rjgbui 58 21 1,000,000 1,000,000 CD cord-289926-y1rjgbui 58 22 times time NNS cord-289926-y1rjgbui 58 23 . . . cord-289926-y1rjgbui 59 1 This this DT cord-289926-y1rjgbui 59 2 is be VBZ cord-289926-y1rjgbui 59 3 a a DT cord-289926-y1rjgbui 59 4 very very RB cord-289926-y1rjgbui 59 5 conservative conservative JJ cord-289926-y1rjgbui 59 6 test test NN cord-289926-y1rjgbui 59 7 since since IN cord-289926-y1rjgbui 59 8 the the DT cord-289926-y1rjgbui 59 9 compositions composition NNS cord-289926-y1rjgbui 59 10 of of IN cord-289926-y1rjgbui 59 11 these these DT cord-289926-y1rjgbui 59 12 segments segment NNS cord-289926-y1rjgbui 59 13 are be VBP cord-289926-y1rjgbui 59 14 biased biased JJ cord-289926-y1rjgbui 59 15 . . . cord-289926-y1rjgbui 60 1 Theory theory NN cord-289926-y1rjgbui 60 2 suggests suggest VBZ cord-289926-y1rjgbui 60 3 that that DT cord-289926-y1rjgbui 60 4 sequence sequence NN cord-289926-y1rjgbui 60 5 alignment alignment NN cord-289926-y1rjgbui 60 6 scores score NNS cord-289926-y1rjgbui 60 7 follow follow VBP cord-289926-y1rjgbui 60 8 an an DT cord-289926-y1rjgbui 60 9 extreme extreme JJ cord-289926-y1rjgbui 60 10 value value NN cord-289926-y1rjgbui 60 11 distribution distribution NN cord-289926-y1rjgbui 60 12 ( ( -LRB- cord-289926-y1rjgbui 60 13 EVD EVD NNP cord-289926-y1rjgbui 60 14 ) ) -RRB- cord-289926-y1rjgbui 60 15 similar similar JJ cord-289926-y1rjgbui 60 16 to to IN cord-289926-y1rjgbui 60 17 that that DT cord-289926-y1rjgbui 60 18 of of IN cord-289926-y1rjgbui 60 19 maximal maximal JJ cord-289926-y1rjgbui 60 20 segment segment NN cord-289926-y1rjgbui 60 21 scores score NNS cord-289926-y1rjgbui 60 22 [ [ -LRB- cord-289926-y1rjgbui 60 23 29 29 CD cord-289926-y1rjgbui 60 24 ] ] -RRB- cord-289926-y1rjgbui 60 25 , , , cord-289926-y1rjgbui 60 26 i.e. i.e. FW cord-289926-y1rjgbui 60 27 The the DT cord-289926-y1rjgbui 60 28 logarithm logarithm NN cord-289926-y1rjgbui 60 29 of of IN cord-289926-y1rjgbui 60 30 the the DT cord-289926-y1rjgbui 60 31 frequencies frequency NNS cord-289926-y1rjgbui 60 32 of of IN cord-289926-y1rjgbui 60 33 occurrence occurrence NN cord-289926-y1rjgbui 60 34 of of IN cord-289926-y1rjgbui 60 35 scores score NNS cord-289926-y1rjgbui 60 36 greater great JJR cord-289926-y1rjgbui 60 37 than than IN cord-289926-y1rjgbui 60 38 or or CC cord-289926-y1rjgbui 60 39 equal equal JJ cord-289926-y1rjgbui 60 40 to to IN cord-289926-y1rjgbui 60 41 specific specific JJ cord-289926-y1rjgbui 60 42 values value NNS cord-289926-y1rjgbui 60 43 were be VBD cord-289926-y1rjgbui 60 44 plotted plot VBN cord-289926-y1rjgbui 60 45 for for IN cord-289926-y1rjgbui 60 46 the the DT cord-289926-y1rjgbui 60 47 top top JJ cord-289926-y1rjgbui 60 48 500 500 CD cord-289926-y1rjgbui 60 49 ( ( -LRB- cord-289926-y1rjgbui 60 50 0.05 0.05 CD cord-289926-y1rjgbui 60 51 % % NN cord-289926-y1rjgbui 60 52 ) ) -RRB- cord-289926-y1rjgbui 60 53 random random JJ cord-289926-y1rjgbui 60 54 alignments alignment NNS cord-289926-y1rjgbui 60 55 and and CC cord-289926-y1rjgbui 60 56 the the DT cord-289926-y1rjgbui 60 57 P p NN cord-289926-y1rjgbui 60 58 - - HYPH cord-289926-y1rjgbui 60 59 values value NNS cord-289926-y1rjgbui 60 60 calculated calculate VBN cord-289926-y1rjgbui 60 61 from from IN cord-289926-y1rjgbui 60 62 the the DT cord-289926-y1rjgbui 60 63 resulting result VBG cord-289926-y1rjgbui 60 64 plot plot NN cord-289926-y1rjgbui 60 65 ( ( -LRB- cord-289926-y1rjgbui 60 66 Fig Fig NNP cord-289926-y1rjgbui 60 67 . . . cord-289926-y1rjgbui 60 68 4 4 CD cord-289926-y1rjgbui 60 69 ) ) -RRB- cord-289926-y1rjgbui 60 70 . . . cord-289926-y1rjgbui 61 1 The the DT cord-289926-y1rjgbui 61 2 similarity similarity NN cord-289926-y1rjgbui 61 3 between between IN cord-289926-y1rjgbui 61 4 the the DT cord-289926-y1rjgbui 61 5 SRY sry NN cord-289926-y1rjgbui 61 6 and and CC cord-289926-y1rjgbui 61 7 HDAg HDAg NNP cord-289926-y1rjgbui 61 8 was be VBD cord-289926-y1rjgbui 61 9 noticed notice VBN cord-289926-y1rjgbui 61 10 during during IN cord-289926-y1rjgbui 61 11 SWISS swiss JJ cord-289926-y1rjgbui 61 12 - - HYPH cord-289926-y1rjgbui 61 13 PROT prot NN cord-289926-y1rjgbui 61 14 database database NN cord-289926-y1rjgbui 61 15 searches search NNS cord-289926-y1rjgbui 61 16 with with IN cord-289926-y1rjgbui 61 17 evolutionary evolutionary JJ cord-289926-y1rjgbui 61 18 profiles profile NNS cord-289926-y1rjgbui 61 19 [ [ -LRB- cord-289926-y1rjgbui 61 20 27 27 CD cord-289926-y1rjgbui 61 21 ] ] -RRB- cord-289926-y1rjgbui 61 22 constructed construct VBN cord-289926-y1rjgbui 61 23 from from IN cord-289926-y1rjgbui 61 24 a a DT cord-289926-y1rjgbui 61 25 multiple multiple JJ cord-289926-y1rjgbui 61 26 alignment alignment NN cord-289926-y1rjgbui 61 27 of of IN cord-289926-y1rjgbui 61 28 the the DT cord-289926-y1rjgbui 61 29 RNA RNA NNP cord-289926-y1rjgbui 61 30 - - HYPH cord-289926-y1rjgbui 61 31 binding bind VBG cord-289926-y1rjgbui 61 32 domain domain NN cord-289926-y1rjgbui 61 33 of of IN cord-289926-y1rjgbui 61 34 HDAg hdag NN cord-289926-y1rjgbui 61 35 from from IN cord-289926-y1rjgbui 61 36 nine nine CD cord-289926-y1rjgbui 61 37 distinct distinct JJ cord-289926-y1rjgbui 61 38 isolates isolate NNS cord-289926-y1rjgbui 61 39 of of IN cord-289926-y1rjgbui 61 40 HDV HDV NNP cord-289926-y1rjgbui 61 41 . . . cord-289926-y1rjgbui 62 1 Searches search NNS cord-289926-y1rjgbui 62 2 with with IN cord-289926-y1rjgbui 62 3 the the DT cord-289926-y1rjgbui 62 4 evolutionary evolutionary JJ cord-289926-y1rjgbui 62 5 profile profile NN cord-289926-y1rjgbui 62 6 identified identify VBD cord-289926-y1rjgbui 62 7 several several JJ cord-289926-y1rjgbui 62 8 target target NN cord-289926-y1rjgbui 62 9 sequences sequence NNS cord-289926-y1rjgbui 62 10 that that WDT cord-289926-y1rjgbui 62 11 contained contain VBD cord-289926-y1rjgbui 62 12 HMG HMG NNP cord-289926-y1rjgbui 62 13 boxes box NNS cord-289926-y1rjgbui 62 14 , , , cord-289926-y1rjgbui 62 15 such such JJ cord-289926-y1rjgbui 62 16 as as IN cord-289926-y1rjgbui 62 17 HMGI HMGI NNP cord-289926-y1rjgbui 62 18 and and CC cord-289926-y1rjgbui 62 19 HMGY HMGY NNP cord-289926-y1rjgbui 62 20 with with IN cord-289926-y1rjgbui 62 21 Z z NN cord-289926-y1rjgbui 62 22 score score NN cord-289926-y1rjgbui 62 23 > > XX cord-289926-y1rjgbui 62 24 7.0 7.0 CD cord-289926-y1rjgbui 62 25 . . . cord-289926-y1rjgbui 63 1 Searches search NNS cord-289926-y1rjgbui 63 2 with with IN cord-289926-y1rjgbui 63 3 profiles profile NNS cord-289926-y1rjgbui 63 4 based base VBN cord-289926-y1rjgbui 63 5 on on IN cord-289926-y1rjgbui 63 6 the the DT cord-289926-y1rjgbui 63 7 predicted predict VBN cord-289926-y1rjgbui 63 8 secondary secondary JJ cord-289926-y1rjgbui 63 9 structures structure NNS cord-289926-y1rjgbui 63 10 identified identify VBD cord-289926-y1rjgbui 63 11 other other JJ cord-289926-y1rjgbui 63 12 HMG HMG NNP cord-289926-y1rjgbui 63 13 products product NNS cord-289926-y1rjgbui 63 14 , , , cord-289926-y1rjgbui 63 15 such such JJ cord-289926-y1rjgbui 63 16 as as IN cord-289926-y1rjgbui 63 17 HMG2 HMG2 NNP cord-289926-y1rjgbui 63 18 HUMAN HUMAN NNP cord-289926-y1rjgbui 63 19 and and CC cord-289926-y1rjgbui 63 20 HMG2 HMG2 NNP cord-289926-y1rjgbui 63 21 MOUSE MOUSE NNP cord-289926-y1rjgbui 63 22 ( ( -LRB- cord-289926-y1rjgbui 63 23 Z z NN cord-289926-y1rjgbui 63 24 score score NN cord-289926-y1rjgbui 63 25 > > XX cord-289926-y1rjgbui 63 26 7.0 7.0 CD cord-289926-y1rjgbui 63 27 ) ) -RRB- cord-289926-y1rjgbui 63 28 , , , cord-289926-y1rjgbui 63 29 and and CC cord-289926-y1rjgbui 63 30 SRY SRY NNP cord-289926-y1rjgbui 63 31 HORSE HORSE NNP cord-289926-y1rjgbui 63 32 ( ( -LRB- cord-289926-y1rjgbui 63 33 Z Z NNP cord-289926-y1rjgbui 63 34 score>6.0 score>6.0 NNP cord-289926-y1rjgbui 63 35 ) ) -RRB- cord-289926-y1rjgbui 63 36 . . . cord-289926-y1rjgbui 64 1 Pairwise pairwise JJ cord-289926-y1rjgbui 64 2 alignments alignment NNS cord-289926-y1rjgbui 64 3 of of IN cord-289926-y1rjgbui 64 4 these these DT cord-289926-y1rjgbui 64 5 target target NN cord-289926-y1rjgbui 64 6 sequences sequence NNS cord-289926-y1rjgbui 64 7 with with IN cord-289926-y1rjgbui 64 8 the the DT cord-289926-y1rjgbui 64 9 RNA RNA NNP cord-289926-y1rjgbui 64 10 - - HYPH cord-289926-y1rjgbui 64 11 binding bind VBG cord-289926-y1rjgbui 64 12 domain domain NN cord-289926-y1rjgbui 64 13 of of IN cord-289926-y1rjgbui 64 14 HDAg HDAg NNS cord-289926-y1rjgbui 64 15 identified identify VBD cord-289926-y1rjgbui 64 16 the the DT cord-289926-y1rjgbui 64 17 HMG HMG NNP cord-289926-y1rjgbui 64 18 box box NN cord-289926-y1rjgbui 64 19 of of IN cord-289926-y1rjgbui 64 20 SRY SRY NNP cord-289926-y1rjgbui 64 21 as as IN cord-289926-y1rjgbui 64 22 most most RBS cord-289926-y1rjgbui 64 23 closely closely RB cord-289926-y1rjgbui 64 24 related related JJ cord-289926-y1rjgbui 64 25 sequence sequence NN cord-289926-y1rjgbui 64 26 . . . cord-289926-y1rjgbui 65 1 We -PRON- PRP cord-289926-y1rjgbui 65 2 then then RB cord-289926-y1rjgbui 65 3 constructed construct VBD cord-289926-y1rjgbui 65 4 profiles profile NNS cord-289926-y1rjgbui 65 5 from from IN cord-289926-y1rjgbui 65 6 the the DT cord-289926-y1rjgbui 65 7 SRY SRY NNP cord-289926-y1rjgbui 65 8 - - HYPH cord-289926-y1rjgbui 65 9 HDAg hdag NN cord-289926-y1rjgbui 65 10 alignment alignment NN cord-289926-y1rjgbui 65 11 , , , cord-289926-y1rjgbui 65 12 which which WDT cord-289926-y1rjgbui 65 13 , , , cord-289926-y1rjgbui 65 14 upon upon IN cord-289926-y1rjgbui 65 15 database database NN cord-289926-y1rjgbui 65 16 search search NN cord-289926-y1rjgbui 65 17 , , , cord-289926-y1rjgbui 65 18 identified identify VBD cord-289926-y1rjgbui 65 19 a a DT cord-289926-y1rjgbui 65 20 large large JJ cord-289926-y1rjgbui 65 21 family family NN cord-289926-y1rjgbui 65 22 of of IN cord-289926-y1rjgbui 65 23 proteins protein NNS cord-289926-y1rjgbui 65 24 containing contain VBG cord-289926-y1rjgbui 65 25 the the DT cord-289926-y1rjgbui 65 26 HMG HMG NNP cord-289926-y1rjgbui 65 27 box box NN cord-289926-y1rjgbui 65 28 : : : cord-289926-y1rjgbui 66 1 SRY sry UH cord-289926-y1rjgbui 66 2 genes gene NNS cord-289926-y1rjgbui 66 3 , , , cord-289926-y1rjgbui 66 4 SRY sry NN cord-289926-y1rjgbui 66 5 - - HYPH cord-289926-y1rjgbui 66 6 related relate VBN cord-289926-y1rjgbui 66 7 genes gene NNS cord-289926-y1rjgbui 66 8 and and CC cord-289926-y1rjgbui 66 9 SOX SOX NNP cord-289926-y1rjgbui 66 10 ( ( -LRB- cord-289926-y1rjgbui 66 11 SRY sry UH cord-289926-y1rjgbui 66 12 box box NN cord-289926-y1rjgbui 66 13 ) ) -RRB- cord-289926-y1rjgbui 66 14 genes gene NNS cord-289926-y1rjgbui 66 15 . . . cord-289926-y1rjgbui 67 1 HDAg HDAg NNP cord-289926-y1rjgbui 67 2 shows show VBZ cord-289926-y1rjgbui 67 3 the the DT cord-289926-y1rjgbui 67 4 highest high JJS cord-289926-y1rjgbui 67 5 similarity similarity NN cord-289926-y1rjgbui 67 6 to to IN cord-289926-y1rjgbui 67 7 the the DT cord-289926-y1rjgbui 67 8 HMG HMG NNP cord-289926-y1rjgbui 67 9 box box NN cord-289926-y1rjgbui 67 10 of of IN cord-289926-y1rjgbui 67 11 the the DT cord-289926-y1rjgbui 67 12 human human JJ cord-289926-y1rjgbui 67 13 SRY SRY NNP cord-289926-y1rjgbui 67 14 and and CC cord-289926-y1rjgbui 67 15 SOX3 SOX3 NNP cord-289926-y1rjgbui 67 16 gene gene NN cord-289926-y1rjgbui 67 17 products product NNS cord-289926-y1rjgbui 67 18 ; ; : cord-289926-y1rjgbui 67 19 for for IN cord-289926-y1rjgbui 67 20 the the DT cord-289926-y1rjgbui 67 21 sake sake NN cord-289926-y1rjgbui 67 22 of of IN cord-289926-y1rjgbui 67 23 clarity clarity NN cord-289926-y1rjgbui 67 24 only only RB cord-289926-y1rjgbui 67 25 the the DT cord-289926-y1rjgbui 67 26 SRY SRY NNP cord-289926-y1rjgbui 67 27 sequence sequence NN cord-289926-y1rjgbui 67 28 is be VBZ cord-289926-y1rjgbui 67 29 shown show VBN cord-289926-y1rjgbui 67 30 in in IN cord-289926-y1rjgbui 67 31 the the DT cord-289926-y1rjgbui 67 32 analysis analysis NN cord-289926-y1rjgbui 67 33 below below RB cord-289926-y1rjgbui 67 34 . . . cord-289926-y1rjgbui 68 1 The the DT cord-289926-y1rjgbui 68 2 best good JJS cord-289926-y1rjgbui 68 3 alignment alignment NN cord-289926-y1rjgbui 68 4 results result NNS cord-289926-y1rjgbui 68 5 are be VBP cord-289926-y1rjgbui 68 6 achieved achieve VBN cord-289926-y1rjgbui 68 7 with with IN cord-289926-y1rjgbui 68 8 the the DT cord-289926-y1rjgbui 68 9 first first JJ cord-289926-y1rjgbui 68 10 47 47 CD cord-289926-y1rjgbui 68 11 residues residue NNS cord-289926-y1rjgbui 68 12 of of IN cord-289926-y1rjgbui 68 13 the the DT cord-289926-y1rjgbui 68 14 HMG HMG NNP cord-289926-y1rjgbui 68 15 box box NN cord-289926-y1rjgbui 68 16 ( ( -LRB- cord-289926-y1rjgbui 68 17 corresponding correspond VBG cord-289926-y1rjgbui 68 18 to to IN cord-289926-y1rjgbui 68 19 residues residue NNS cord-289926-y1rjgbui 68 20 59 59 CD cord-289926-y1rjgbui 68 21 - - SYM cord-289926-y1rjgbui 68 22 105 105 CD cord-289926-y1rjgbui 68 23 of of IN cord-289926-y1rjgbui 68 24 SRY SRY NNP cord-289926-y1rjgbui 68 25 ) ) -RRB- cord-289926-y1rjgbui 68 26 aligned align VBN cord-289926-y1rjgbui 68 27 to to IN cord-289926-y1rjgbui 68 28 the the DT cord-289926-y1rjgbui 68 29 42 42 CD cord-289926-y1rjgbui 68 30 residues residue NNS cord-289926-y1rjgbui 68 31 of of IN cord-289926-y1rjgbui 68 32 RNA rna NN cord-289926-y1rjgbui 68 33 - - HYPH cord-289926-y1rjgbui 68 34 binding bind VBG cord-289926-y1rjgbui 68 35 motif motif NN cord-289926-y1rjgbui 68 36 of of IN cord-289926-y1rjgbui 68 37 HDAg hdag NN cord-289926-y1rjgbui 68 38 ( ( -LRB- cord-289926-y1rjgbui 68 39 corresponding correspond VBG cord-289926-y1rjgbui 68 40 to to IN cord-289926-y1rjgbui 68 41 the the DT cord-289926-y1rjgbui 68 42 residues residue NNS cord-289926-y1rjgbui 68 43 86 86 CD cord-289926-y1rjgbui 68 44 - - SYM cord-289926-y1rjgbui 68 45 127 127 CD cord-289926-y1rjgbui 68 46 ) ) -RRB- cord-289926-y1rjgbui 68 47 : : : cord-289926-y1rjgbui 68 48 54 54 CD cord-289926-y1rjgbui 68 49 % % NN cord-289926-y1rjgbui 68 50 identity identity NN cord-289926-y1rjgbui 68 51 and and CC cord-289926-y1rjgbui 68 52 72 72 CD cord-289926-y1rjgbui 68 53 % % NN cord-289926-y1rjgbui 68 54 sequence sequence NN cord-289926-y1rjgbui 68 55 similarity similarity NN cord-289926-y1rjgbui 68 56 are be VBP cord-289926-y1rjgbui 68 57 observed observe VBN cord-289926-y1rjgbui 68 58 ( ( -LRB- cord-289926-y1rjgbui 68 59 Fig Fig NNP cord-289926-y1rjgbui 68 60 . . . cord-289926-y1rjgbui 68 61 2A 2a CD cord-289926-y1rjgbui 68 62 ) ) -RRB- cord-289926-y1rjgbui 68 63 . . . cord-289926-y1rjgbui 69 1 This this DT cord-289926-y1rjgbui 69 2 region region NN cord-289926-y1rjgbui 69 3 covers cover VBZ cord-289926-y1rjgbui 69 4 the the DT cord-289926-y1rjgbui 69 5 first first JJ cord-289926-y1rjgbui 69 6 ARM arm NN cord-289926-y1rjgbui 69 7 and and CC cord-289926-y1rjgbui 69 8 part part NN cord-289926-y1rjgbui 69 9 of of IN cord-289926-y1rjgbui 69 10 the the DT cord-289926-y1rjgbui 69 11 leucine leucine NNP cord-289926-y1rjgbui 69 12 zipper zipper NN cord-289926-y1rjgbui 69 13 region region NN cord-289926-y1rjgbui 69 14 . . . cord-289926-y1rjgbui 70 1 This this DT cord-289926-y1rjgbui 70 2 is be VBZ cord-289926-y1rjgbui 70 3 the the DT cord-289926-y1rjgbui 70 4 only only JJ cord-289926-y1rjgbui 70 5 alignment alignment NN cord-289926-y1rjgbui 70 6 that that WDT cord-289926-y1rjgbui 70 7 produces produce VBZ cord-289926-y1rjgbui 70 8 a a DT cord-289926-y1rjgbui 70 9 significant significant JJ cord-289926-y1rjgbui 70 10 Z z NN cord-289926-y1rjgbui 70 11 score score NN cord-289926-y1rjgbui 70 12 ( ( -LRB- cord-289926-y1rjgbui 70 13 see see VB cord-289926-y1rjgbui 70 14 below below RB cord-289926-y1rjgbui 70 15 ) ) -RRB- cord-289926-y1rjgbui 70 16 . . . cord-289926-y1rjgbui 71 1 A a DT cord-289926-y1rjgbui 71 2 longer long JJR cord-289926-y1rjgbui 71 3 alignment alignment NN cord-289926-y1rjgbui 71 4 ( ( -LRB- cord-289926-y1rjgbui 71 5 Fig Fig NNP cord-289926-y1rjgbui 71 6 . . . cord-289926-y1rjgbui 71 7 2B 2B NNP cord-289926-y1rjgbui 71 8 ) ) -RRB- cord-289926-y1rjgbui 71 9 covers cover VBZ cord-289926-y1rjgbui 71 10 two two CD cord-289926-y1rjgbui 71 11 ARMs arm NNS cord-289926-y1rjgbui 71 12 bracketing bracket VBG cord-289926-y1rjgbui 71 13 a a DT cord-289926-y1rjgbui 71 14 leucine leucine NN cord-289926-y1rjgbui 71 15 zipper zipper NN cord-289926-y1rjgbui 71 16 , , , cord-289926-y1rjgbui 71 17 which which WDT cord-289926-y1rjgbui 71 18 together together RB cord-289926-y1rjgbui 71 19 comprise comprise VBP cord-289926-y1rjgbui 71 20 the the DT cord-289926-y1rjgbui 71 21 RNA RNA NNP cord-289926-y1rjgbui 71 22 - - HYPH cord-289926-y1rjgbui 71 23 binding bind VBG cord-289926-y1rjgbui 71 24 motif motif NN cord-289926-y1rjgbui 71 25 in in IN cord-289926-y1rjgbui 71 26 HDAg hdag NN cord-289926-y1rjgbui 71 27 . . . cord-289926-y1rjgbui 72 1 This this DT cord-289926-y1rjgbui 72 2 longer long JJR cord-289926-y1rjgbui 72 3 alignment alignment NN cord-289926-y1rjgbui 72 4 between between IN cord-289926-y1rjgbui 72 5 HDAg hdag NN cord-289926-y1rjgbui 72 6 and and CC cord-289926-y1rjgbui 72 7 SRY SRY NNP cord-289926-y1rjgbui 72 8 proteins protein NNS cord-289926-y1rjgbui 72 9 extends extend VBZ cord-289926-y1rjgbui 72 10 though though IN cord-289926-y1rjgbui 72 11 the the DT cord-289926-y1rjgbui 72 12 C C NNP cord-289926-y1rjgbui 72 13 - - HYPH cord-289926-y1rjgbui 72 14 terminal terminal NN cord-289926-y1rjgbui 72 15 region region NN cord-289926-y1rjgbui 72 16 of of IN cord-289926-y1rjgbui 72 17 both both DT cord-289926-y1rjgbui 72 18 proteins protein NNS cord-289926-y1rjgbui 72 19 ; ; : cord-289926-y1rjgbui 72 20 it -PRON- PRP cord-289926-y1rjgbui 72 21 exhibits exhibit VBZ cord-289926-y1rjgbui 72 22 33 33 CD cord-289926-y1rjgbui 72 23 % % NN cord-289926-y1rjgbui 72 24 identity identity NN cord-289926-y1rjgbui 72 25 and and CC cord-289926-y1rjgbui 72 26 59 59 CD cord-289926-y1rjgbui 72 27 % % NN cord-289926-y1rjgbui 72 28 similarity similarity NN cord-289926-y1rjgbui 72 29 ( ( -LRB- cord-289926-y1rjgbui 72 30 Fig Fig NNP cord-289926-y1rjgbui 72 31 . . . cord-289926-y1rjgbui 72 32 2B 2b CD cord-289926-y1rjgbui 72 33 ) ) -RRB- cord-289926-y1rjgbui 72 34 . . . cord-289926-y1rjgbui 73 1 The the DT cord-289926-y1rjgbui 73 2 similarity similarity NN cord-289926-y1rjgbui 73 3 in in IN cord-289926-y1rjgbui 73 4 HDAg hdag NN cord-289926-y1rjgbui 73 5 begins begin VBZ cord-289926-y1rjgbui 73 6 ten ten CD cord-289926-y1rjgbui 73 7 residues residue NNS cord-289926-y1rjgbui 73 8 upstream upstream RB cord-289926-y1rjgbui 73 9 of of IN cord-289926-y1rjgbui 73 10 the the DT cord-289926-y1rjgbui 73 11 left left JJ cord-289926-y1rjgbui 73 12 ARM arm NN cord-289926-y1rjgbui 73 13 and and CC cord-289926-y1rjgbui 73 14 continues continue VBZ cord-289926-y1rjgbui 73 15 into into IN cord-289926-y1rjgbui 73 16 the the DT cord-289926-y1rjgbui 73 17 leucine leucine NN cord-289926-y1rjgbui 73 18 zipper zipper NN cord-289926-y1rjgbui 73 19 , , , cord-289926-y1rjgbui 73 20 where where WRB cord-289926-y1rjgbui 73 21 similarity similarity NN cord-289926-y1rjgbui 73 22 gradually gradually RB cord-289926-y1rjgbui 73 23 weakens weaken VBZ cord-289926-y1rjgbui 73 24 but but CC cord-289926-y1rjgbui 73 25 is be VBZ cord-289926-y1rjgbui 73 26 still still RB cord-289926-y1rjgbui 73 27 detectable detectable JJ cord-289926-y1rjgbui 73 28 through through IN cord-289926-y1rjgbui 73 29 the the DT cord-289926-y1rjgbui 73 30 right right JJ cord-289926-y1rjgbui 73 31 ARM arm NN cord-289926-y1rjgbui 73 32 of of IN cord-289926-y1rjgbui 73 33 HDAg hdag NN cord-289926-y1rjgbui 73 34 ( ( -LRB- cord-289926-y1rjgbui 73 35 Fig Fig NNP cord-289926-y1rjgbui 73 36 . . NNP cord-289926-y1rjgbui 73 37 1 1 CD cord-289926-y1rjgbui 73 38 , , , cord-289926-y1rjgbui 73 39 2B 2b CD cord-289926-y1rjgbui 73 40 ) ) -RRB- cord-289926-y1rjgbui 73 41 . . . cord-289926-y1rjgbui 74 1 When when WRB cord-289926-y1rjgbui 74 2 HDAg HDAg NNP cord-289926-y1rjgbui 74 3 was be VBD cord-289926-y1rjgbui 74 4 aligned align VBN cord-289926-y1rjgbui 74 5 with with IN cord-289926-y1rjgbui 74 6 ARM arm NN cord-289926-y1rjgbui 74 7 - - HYPH cord-289926-y1rjgbui 74 8 containing contain VBG cord-289926-y1rjgbui 74 9 sequences sequence NNS cord-289926-y1rjgbui 74 10 , , , cord-289926-y1rjgbui 74 11 the the DT cord-289926-y1rjgbui 74 12 best good JJS cord-289926-y1rjgbui 74 13 alignment alignment NN cord-289926-y1rjgbui 74 14 was be VBD cord-289926-y1rjgbui 74 15 found find VBN cord-289926-y1rjgbui 74 16 with with IN cord-289926-y1rjgbui 74 17 HIV HIV NNP cord-289926-y1rjgbui 74 18 rev rev NNP cord-289926-y1rjgbui 74 19 gene gene NN cord-289926-y1rjgbui 74 20 product product NN cord-289926-y1rjgbui 74 21 . . . cord-289926-y1rjgbui 75 1 This this DT cord-289926-y1rjgbui 75 2 alignment alignment NN cord-289926-y1rjgbui 75 3 shows show VBZ cord-289926-y1rjgbui 75 4 39 39 CD cord-289926-y1rjgbui 75 5 % % NN cord-289926-y1rjgbui 75 6 identity identity NN cord-289926-y1rjgbui 75 7 and and CC cord-289926-y1rjgbui 75 8 63 63 CD cord-289926-y1rjgbui 75 9 % % NN cord-289926-y1rjgbui 75 10 similarity similarity NN cord-289926-y1rjgbui 75 11 across across IN cord-289926-y1rjgbui 75 12 the the DT cord-289926-y1rjgbui 75 13 entire entire JJ cord-289926-y1rjgbui 75 14 rev rev NNP cord-289926-y1rjgbui 75 15 gene gene NN cord-289926-y1rjgbui 75 16 ( ( -LRB- cord-289926-y1rjgbui 75 17 Fig Fig NNP cord-289926-y1rjgbui 75 18 . . . cord-289926-y1rjgbui 75 19 2F 2F NNP cord-289926-y1rjgbui 75 20 ) ) -RRB- cord-289926-y1rjgbui 75 21 . . . cord-289926-y1rjgbui 76 1 The the DT cord-289926-y1rjgbui 76 2 alignment alignment NN cord-289926-y1rjgbui 76 3 of of IN cord-289926-y1rjgbui 76 4 HDAg hdag NN cord-289926-y1rjgbui 76 5 and and CC cord-289926-y1rjgbui 76 6 DIPA DIPA NNP cord-289926-y1rjgbui 76 7 , , , cord-289926-y1rjgbui 76 8 a a DT cord-289926-y1rjgbui 76 9 proposed propose VBN cord-289926-y1rjgbui 76 10 cellular cellular JJ cord-289926-y1rjgbui 76 11 homolog homolog NN cord-289926-y1rjgbui 76 12 of of IN cord-289926-y1rjgbui 76 13 HDAg HDAg NNPS cord-289926-y1rjgbui 76 14 [ [ -LRB- cord-289926-y1rjgbui 76 15 5 5 CD cord-289926-y1rjgbui 76 16 ] ] -RRB- cord-289926-y1rjgbui 76 17 , , , cord-289926-y1rjgbui 76 18 shows show VBZ cord-289926-y1rjgbui 76 19 34 34 CD cord-289926-y1rjgbui 76 20 % % NN cord-289926-y1rjgbui 76 21 identity identity NN cord-289926-y1rjgbui 76 22 and and CC cord-289926-y1rjgbui 76 23 57 57 CD cord-289926-y1rjgbui 76 24 % % NN cord-289926-y1rjgbui 76 25 similarity similarity NN cord-289926-y1rjgbui 76 26 across across IN cord-289926-y1rjgbui 76 27 the the DT cord-289926-y1rjgbui 76 28 entire entire JJ cord-289926-y1rjgbui 76 29 length length NN cord-289926-y1rjgbui 76 30 of of IN cord-289926-y1rjgbui 76 31 the the DT cord-289926-y1rjgbui 76 32 protein protein NN cord-289926-y1rjgbui 76 33 sequences sequence NNS cord-289926-y1rjgbui 76 34 ( ( -LRB- cord-289926-y1rjgbui 76 35 Fig Fig NNP cord-289926-y1rjgbui 76 36 . . . cord-289926-y1rjgbui 76 37 2D 2D NNP cord-289926-y1rjgbui 76 38 ) ) -RRB- cord-289926-y1rjgbui 76 39 . . . cord-289926-y1rjgbui 77 1 The the DT cord-289926-y1rjgbui 77 2 similarity similarity NN cord-289926-y1rjgbui 77 3 is be VBZ cord-289926-y1rjgbui 77 4 distributed distribute VBN cord-289926-y1rjgbui 77 5 across across IN cord-289926-y1rjgbui 77 6 the the DT cord-289926-y1rjgbui 77 7 entire entire JJ cord-289926-y1rjgbui 77 8 sequence sequence NN cord-289926-y1rjgbui 77 9 , , , cord-289926-y1rjgbui 77 10 however however RB cord-289926-y1rjgbui 77 11 , , , cord-289926-y1rjgbui 77 12 the the DT cord-289926-y1rjgbui 77 13 amino amino NN cord-289926-y1rjgbui 77 14 - - HYPH cord-289926-y1rjgbui 77 15 terminal terminal NN cord-289926-y1rjgbui 77 16 and and CC cord-289926-y1rjgbui 77 17 central central JJ cord-289926-y1rjgbui 77 18 regions region NNS cord-289926-y1rjgbui 77 19 show show VBP cord-289926-y1rjgbui 77 20 a a DT cord-289926-y1rjgbui 77 21 somewhat somewhat RB cord-289926-y1rjgbui 77 22 higher high JJR cord-289926-y1rjgbui 77 23 level level NN cord-289926-y1rjgbui 77 24 of of IN cord-289926-y1rjgbui 77 25 similarity similarity NN cord-289926-y1rjgbui 77 26 ( ( -LRB- cord-289926-y1rjgbui 77 27 Fig Fig NNP cord-289926-y1rjgbui 77 28 . . . cord-289926-y1rjgbui 77 29 2D 2D NNP cord-289926-y1rjgbui 77 30 ) ) -RRB- cord-289926-y1rjgbui 77 31 . . . cord-289926-y1rjgbui 78 1 Our -PRON- PRP$ cord-289926-y1rjgbui 78 2 analysis analysis NN cord-289926-y1rjgbui 78 3 is be VBZ cord-289926-y1rjgbui 78 4 focused focus VBN cord-289926-y1rjgbui 78 5 on on IN cord-289926-y1rjgbui 78 6 the the DT cord-289926-y1rjgbui 78 7 central central JJ cord-289926-y1rjgbui 78 8 region region NN cord-289926-y1rjgbui 78 9 of of IN cord-289926-y1rjgbui 78 10 HDAg HDAg NNS cord-289926-y1rjgbui 78 11 which which WDT cord-289926-y1rjgbui 78 12 shows show VBZ cord-289926-y1rjgbui 78 13 higher high JJR cord-289926-y1rjgbui 78 14 level level NN cord-289926-y1rjgbui 78 15 of of IN cord-289926-y1rjgbui 78 16 sequence sequence NN cord-289926-y1rjgbui 78 17 similarity similarity NN cord-289926-y1rjgbui 78 18 and and CC cord-289926-y1rjgbui 78 19 also also RB cord-289926-y1rjgbui 78 20 corresponds correspond VBZ cord-289926-y1rjgbui 78 21 to to IN cord-289926-y1rjgbui 78 22 the the DT cord-289926-y1rjgbui 78 23 most most RBS cord-289926-y1rjgbui 78 24 similar similar JJ cord-289926-y1rjgbui 78 25 region region NN cord-289926-y1rjgbui 78 26 of of IN cord-289926-y1rjgbui 78 27 HDAg hdag NN cord-289926-y1rjgbui 78 28 and and CC cord-289926-y1rjgbui 78 29 SRY sry UH cord-289926-y1rjgbui 78 30 . . . cord-289926-y1rjgbui 79 1 This this DT cord-289926-y1rjgbui 79 2 55-residue 55-residue CD cord-289926-y1rjgbui 79 3 long long JJ cord-289926-y1rjgbui 79 4 subsequence subsequence NN cord-289926-y1rjgbui 79 5 corresponds correspond VBZ cord-289926-y1rjgbui 79 6 to to IN cord-289926-y1rjgbui 79 7 the the DT cord-289926-y1rjgbui 79 8 first first JJ cord-289926-y1rjgbui 79 9 arginine arginine NN cord-289926-y1rjgbui 79 10 rich rich JJ cord-289926-y1rjgbui 79 11 motif motif NN cord-289926-y1rjgbui 79 12 ( ( -LRB- cord-289926-y1rjgbui 79 13 ARM arm NN cord-289926-y1rjgbui 79 14 ) ) -RRB- cord-289926-y1rjgbui 79 15 and and CC cord-289926-y1rjgbui 79 16 most most JJS cord-289926-y1rjgbui 79 17 of of IN cord-289926-y1rjgbui 79 18 the the DT cord-289926-y1rjgbui 79 19 leucine leucine NNP cord-289926-y1rjgbui 79 20 zipper zipper NN cord-289926-y1rjgbui 79 21 of of IN cord-289926-y1rjgbui 79 22 HDAg HDAg NNP cord-289926-y1rjgbui 79 23 ( ( -LRB- cord-289926-y1rjgbui 79 24 Fig Fig NNP cord-289926-y1rjgbui 79 25 . . . cord-289926-y1rjgbui 79 26 2C 2C NNP cord-289926-y1rjgbui 79 27 ) ) -RRB- cord-289926-y1rjgbui 79 28 . . . cord-289926-y1rjgbui 80 1 The the DT cord-289926-y1rjgbui 80 2 levels level NNS cord-289926-y1rjgbui 80 3 of of IN cord-289926-y1rjgbui 80 4 residue residue NN cord-289926-y1rjgbui 80 5 identity identity NN cord-289926-y1rjgbui 80 6 and and CC cord-289926-y1rjgbui 80 7 similarity similarity NN cord-289926-y1rjgbui 80 8 of of IN cord-289926-y1rjgbui 80 9 this this DT cord-289926-y1rjgbui 80 10 alignment alignment NN cord-289926-y1rjgbui 80 11 are be VBP cord-289926-y1rjgbui 80 12 45 45 CD cord-289926-y1rjgbui 80 13 % % NN cord-289926-y1rjgbui 80 14 and and CC cord-289926-y1rjgbui 80 15 63 63 CD cord-289926-y1rjgbui 80 16 % % NN cord-289926-y1rjgbui 80 17 respectively respectively RB cord-289926-y1rjgbui 80 18 . . . cord-289926-y1rjgbui 81 1 As as IN cord-289926-y1rjgbui 81 2 a a DT cord-289926-y1rjgbui 81 3 control control NN cord-289926-y1rjgbui 81 4 , , , cord-289926-y1rjgbui 81 5 DIPA DIPA NNP cord-289926-y1rjgbui 81 6 was be VBD cord-289926-y1rjgbui 81 7 also also RB cord-289926-y1rjgbui 81 8 aligned align VBN cord-289926-y1rjgbui 81 9 with with IN cord-289926-y1rjgbui 81 10 HIV HIV NNP cord-289926-y1rjgbui 81 11 rev rev NNP cord-289926-y1rjgbui 81 12 -an -an NNP cord-289926-y1rjgbui 81 13 ARM ARM NNP cord-289926-y1rjgbui 81 14 containing contain VBG cord-289926-y1rjgbui 81 15 protein protein NN cord-289926-y1rjgbui 81 16 unrelated unrelated JJ cord-289926-y1rjgbui 81 17 to to IN cord-289926-y1rjgbui 81 18 DIPA DIPA NNP cord-289926-y1rjgbui 81 19 or or CC cord-289926-y1rjgbui 81 20 HDAg hdag NN cord-289926-y1rjgbui 81 21 . . . cord-289926-y1rjgbui 82 1 This this DT cord-289926-y1rjgbui 82 2 alignment alignment NN cord-289926-y1rjgbui 82 3 shows show VBZ cord-289926-y1rjgbui 82 4 45 45 CD cord-289926-y1rjgbui 82 5 % % NN cord-289926-y1rjgbui 82 6 identity identity NN cord-289926-y1rjgbui 82 7 and and CC cord-289926-y1rjgbui 82 8 74 74 CD cord-289926-y1rjgbui 82 9 % % NN cord-289926-y1rjgbui 82 10 similarity similarity NN cord-289926-y1rjgbui 82 11 across across IN cord-289926-y1rjgbui 82 12 entire entire JJ cord-289926-y1rjgbui 82 13 length length NN cord-289926-y1rjgbui 82 14 of of IN cord-289926-y1rjgbui 82 15 89-residue 89-residue CD cord-289926-y1rjgbui 82 16 long long JJ cord-289926-y1rjgbui 82 17 rev rev NNP cord-289926-y1rjgbui 82 18 protein protein NN cord-289926-y1rjgbui 82 19 ( ( -LRB- cord-289926-y1rjgbui 82 20 Fig Fig NNP cord-289926-y1rjgbui 82 21 . . . cord-289926-y1rjgbui 82 22 2E 2E NNP cord-289926-y1rjgbui 82 23 ) ) -RRB- cord-289926-y1rjgbui 82 24 . . . cord-289926-y1rjgbui 83 1 The the DT cord-289926-y1rjgbui 83 2 HMG HMG NNP cord-289926-y1rjgbui 83 3 box box NN cord-289926-y1rjgbui 83 4 of of IN cord-289926-y1rjgbui 83 5 SRY SRY NNP cord-289926-y1rjgbui 83 6 belongs belong VBZ cord-289926-y1rjgbui 83 7 to to IN cord-289926-y1rjgbui 83 8 the the DT cord-289926-y1rjgbui 83 9 HMG-1 HMG-1 NNP cord-289926-y1rjgbui 83 10 subgroup subgroup NN cord-289926-y1rjgbui 83 11 . . . cord-289926-y1rjgbui 84 1 Many many JJ cord-289926-y1rjgbui 84 2 of of IN cord-289926-y1rjgbui 84 3 the the DT cord-289926-y1rjgbui 84 4 residues residue NNS cord-289926-y1rjgbui 84 5 that that WDT cord-289926-y1rjgbui 84 6 are be VBP cord-289926-y1rjgbui 84 7 conserved conserve VBN cord-289926-y1rjgbui 84 8 between between IN cord-289926-y1rjgbui 84 9 the the DT cord-289926-y1rjgbui 84 10 HMG HMG NNP cord-289926-y1rjgbui 84 11 box box NN cord-289926-y1rjgbui 84 12 of of IN cord-289926-y1rjgbui 84 13 SRY SRY NNP cord-289926-y1rjgbui 84 14 and and CC cord-289926-y1rjgbui 84 15 HMG1.2 HMG1.2 NNP cord-289926-y1rjgbui 84 16 are be VBP cord-289926-y1rjgbui 84 17 also also RB cord-289926-y1rjgbui 84 18 conserved conserve VBN cord-289926-y1rjgbui 84 19 in in IN cord-289926-y1rjgbui 84 20 the the DT cord-289926-y1rjgbui 84 21 alignment alignment NN cord-289926-y1rjgbui 84 22 between between IN cord-289926-y1rjgbui 84 23 SRY SRY NNP cord-289926-y1rjgbui 84 24 and and CC cord-289926-y1rjgbui 84 25 the the DT cord-289926-y1rjgbui 84 26 RNA RNA NNP cord-289926-y1rjgbui 84 27 - - HYPH cord-289926-y1rjgbui 84 28 binding bind VBG cord-289926-y1rjgbui 84 29 domain domain NN cord-289926-y1rjgbui 84 30 of of IN cord-289926-y1rjgbui 84 31 HDAg hdag NN cord-289926-y1rjgbui 84 32 ( ( -LRB- cord-289926-y1rjgbui 84 33 data datum NNS cord-289926-y1rjgbui 84 34 not not RB cord-289926-y1rjgbui 84 35 shown show VBN cord-289926-y1rjgbui 84 36 ) ) -RRB- cord-289926-y1rjgbui 84 37 . . . cord-289926-y1rjgbui 85 1 To to TO cord-289926-y1rjgbui 85 2 identify identify VB cord-289926-y1rjgbui 85 3 the the DT cord-289926-y1rjgbui 85 4 residues residue NNS cord-289926-y1rjgbui 85 5 that that WDT cord-289926-y1rjgbui 85 6 are be VBP cord-289926-y1rjgbui 85 7 conserved conserve VBN cord-289926-y1rjgbui 85 8 among among IN cord-289926-y1rjgbui 85 9 all all DT cord-289926-y1rjgbui 85 10 sequences sequence NNS cord-289926-y1rjgbui 85 11 , , , cord-289926-y1rjgbui 85 12 we -PRON- PRP cord-289926-y1rjgbui 85 13 aligned align VBD cord-289926-y1rjgbui 85 14 the the DT cord-289926-y1rjgbui 85 15 sequences sequence NNS cord-289926-y1rjgbui 85 16 of of IN cord-289926-y1rjgbui 85 17 SRY SRY NNP cord-289926-y1rjgbui 85 18 , , , cord-289926-y1rjgbui 85 19 SOX3 SOX3 NNP cord-289926-y1rjgbui 85 20 , , , cord-289926-y1rjgbui 85 21 HMG1.2 HMG1.2 NNP cord-289926-y1rjgbui 85 22 and and CC cord-289926-y1rjgbui 85 23 the the DT cord-289926-y1rjgbui 85 24 RNA RNA NNP cord-289926-y1rjgbui 85 25 - - HYPH cord-289926-y1rjgbui 85 26 binding bind VBG cord-289926-y1rjgbui 85 27 domain domain NN cord-289926-y1rjgbui 85 28 of of IN cord-289926-y1rjgbui 85 29 HDAg hdag NN cord-289926-y1rjgbui 85 30 to to IN cord-289926-y1rjgbui 85 31 the the DT cord-289926-y1rjgbui 85 32 profile profile NN cord-289926-y1rjgbui 85 33 of of IN cord-289926-y1rjgbui 85 34 SRY sry NN cord-289926-y1rjgbui 85 35 and and CC cord-289926-y1rjgbui 85 36 HDAg hdag NN cord-289926-y1rjgbui 85 37 sequences sequence NNS cord-289926-y1rjgbui 85 38 ( ( -LRB- cord-289926-y1rjgbui 85 39 Fig Fig NNP cord-289926-y1rjgbui 85 40 . . . cord-289926-y1rjgbui 85 41 3A 3A NNP cord-289926-y1rjgbui 85 42 ) ) -RRB- cord-289926-y1rjgbui 85 43 . . . cord-289926-y1rjgbui 86 1 A a DT cord-289926-y1rjgbui 86 2 total total NN cord-289926-y1rjgbui 86 3 of of IN cord-289926-y1rjgbui 86 4 17 17 CD cord-289926-y1rjgbui 86 5 residues residue NNS cord-289926-y1rjgbui 86 6 are be VBP cord-289926-y1rjgbui 86 7 identical identical JJ cord-289926-y1rjgbui 86 8 between between IN cord-289926-y1rjgbui 86 9 SOX3 SOX3 NNP cord-289926-y1rjgbui 86 10 , , , cord-289926-y1rjgbui 86 11 SRY SRY NNP cord-289926-y1rjgbui 86 12 and and CC cord-289926-y1rjgbui 86 13 HMG1.2 HMG1.2 NNP cord-289926-y1rjgbui 86 14 ; ; : cord-289926-y1rjgbui 86 15 the the DT cord-289926-y1rjgbui 86 16 alignment alignment NN cord-289926-y1rjgbui 86 17 of of IN cord-289926-y1rjgbui 86 18 the the DT cord-289926-y1rjgbui 86 19 RNA RNA NNP cord-289926-y1rjgbui 86 20 - - HYPH cord-289926-y1rjgbui 86 21 binding bind VBG cord-289926-y1rjgbui 86 22 domain domain NN cord-289926-y1rjgbui 86 23 of of IN cord-289926-y1rjgbui 86 24 HDAg hdag NN cord-289926-y1rjgbui 86 25 shares share NNS cord-289926-y1rjgbui 86 26 10 10 CD cord-289926-y1rjgbui 86 27 of of IN cord-289926-y1rjgbui 86 28 these these DT cord-289926-y1rjgbui 86 29 identities identity NNS cord-289926-y1rjgbui 86 30 . . . cord-289926-y1rjgbui 87 1 The the DT cord-289926-y1rjgbui 87 2 identities identity NNS cord-289926-y1rjgbui 87 3 are be VBP cord-289926-y1rjgbui 87 4 concentrated concentrate VBN cord-289926-y1rjgbui 87 5 in in IN cord-289926-y1rjgbui 87 6 the the DT cord-289926-y1rjgbui 87 7 first first JJ cord-289926-y1rjgbui 87 8 2 2 CD cord-289926-y1rjgbui 87 9 of of IN cord-289926-y1rjgbui 87 10 the the DT cord-289926-y1rjgbui 87 11 3 3 CD cord-289926-y1rjgbui 87 12 helices helix NNS cord-289926-y1rjgbui 87 13 predicted predict VBN cord-289926-y1rjgbui 87 14 for for IN cord-289926-y1rjgbui 87 15 the the DT cord-289926-y1rjgbui 87 16 HMG-1 HMG-1 NNP cord-289926-y1rjgbui 87 17 subgroup subgroup NN cord-289926-y1rjgbui 88 1 ( ( -LRB- cord-289926-y1rjgbui 88 2 Fig Fig NNP cord-289926-y1rjgbui 88 3 . . . cord-289926-y1rjgbui 88 4 3A 3A NNP cord-289926-y1rjgbui 88 5 , , , cord-289926-y1rjgbui 88 6 3B 3B NNP cord-289926-y1rjgbui 88 7 ) ) -RRB- cord-289926-y1rjgbui 88 8 . . . cord-289926-y1rjgbui 89 1 HDAg HDAg NNP cord-289926-y1rjgbui 89 2 , , , cord-289926-y1rjgbui 89 3 SRY sry UH cord-289926-y1rjgbui 89 4 and and CC cord-289926-y1rjgbui 89 5 DIPA DIPA NNP cord-289926-y1rjgbui 89 6 contain contain VBP cord-289926-y1rjgbui 89 7 arginine arginine NN cord-289926-y1rjgbui 89 8 rich rich JJ cord-289926-y1rjgbui 89 9 motifs motif NNS cord-289926-y1rjgbui 89 10 . . . cord-289926-y1rjgbui 90 1 This this DT cord-289926-y1rjgbui 90 2 compositional compositional JJ cord-289926-y1rjgbui 90 3 bias bias NN cord-289926-y1rjgbui 90 4 can can MD cord-289926-y1rjgbui 90 5 lead lead VB cord-289926-y1rjgbui 90 6 to to IN cord-289926-y1rjgbui 90 7 overestimation overestimation NN cord-289926-y1rjgbui 90 8 of of IN cord-289926-y1rjgbui 90 9 the the DT cord-289926-y1rjgbui 90 10 significance significance NN cord-289926-y1rjgbui 90 11 of of IN cord-289926-y1rjgbui 90 12 sequence sequence NN cord-289926-y1rjgbui 90 13 similarity similarity NN cord-289926-y1rjgbui 90 14 in in IN cord-289926-y1rjgbui 90 15 the the DT cord-289926-y1rjgbui 90 16 pairwise pairwise JJ cord-289926-y1rjgbui 90 17 alignments alignment NNS cord-289926-y1rjgbui 90 18 . . . cord-289926-y1rjgbui 91 1 To to TO cord-289926-y1rjgbui 91 2 verify verify VB cord-289926-y1rjgbui 91 3 that that IN cord-289926-y1rjgbui 91 4 the the DT cord-289926-y1rjgbui 91 5 above above JJ cord-289926-y1rjgbui 91 6 HDAg hdag NN cord-289926-y1rjgbui 91 7 alignments alignment NNS cord-289926-y1rjgbui 91 8 are be VBP cord-289926-y1rjgbui 91 9 not not RB cord-289926-y1rjgbui 91 10 due due JJ cord-289926-y1rjgbui 91 11 to to IN cord-289926-y1rjgbui 91 12 compositional compositional JJ cord-289926-y1rjgbui 91 13 bias bias NN cord-289926-y1rjgbui 91 14 of of IN cord-289926-y1rjgbui 91 15 the the DT cord-289926-y1rjgbui 91 16 sequences sequence NNS cord-289926-y1rjgbui 91 17 , , , cord-289926-y1rjgbui 91 18 a a DT cord-289926-y1rjgbui 91 19 Monte Monte NNP cord-289926-y1rjgbui 91 20 Carlo Carlo NNP cord-289926-y1rjgbui 91 21 analysis analysis NN cord-289926-y1rjgbui 91 22 was be VBD cord-289926-y1rjgbui 91 23 performed perform VBN cord-289926-y1rjgbui 91 24 for for IN cord-289926-y1rjgbui 91 25 each each DT cord-289926-y1rjgbui 91 26 of of IN cord-289926-y1rjgbui 91 27 the the DT cord-289926-y1rjgbui 91 28 pairwise pairwise JJ cord-289926-y1rjgbui 91 29 alignments alignment NNS cord-289926-y1rjgbui 91 30 . . . cord-289926-y1rjgbui 92 1 One one CD cord-289926-y1rjgbui 92 2 sequence sequence NN cord-289926-y1rjgbui 92 3 was be VBD cord-289926-y1rjgbui 92 4 shuffled shuffle VBN cord-289926-y1rjgbui 92 5 and and CC cord-289926-y1rjgbui 92 6 then then RB cord-289926-y1rjgbui 92 7 realigned realign VBD cord-289926-y1rjgbui 92 8 to to IN cord-289926-y1rjgbui 92 9 the the DT cord-289926-y1rjgbui 92 10 other other JJ cord-289926-y1rjgbui 92 11 sequence sequence NN cord-289926-y1rjgbui 92 12 under under IN cord-289926-y1rjgbui 92 13 the the DT cord-289926-y1rjgbui 92 14 initial initial JJ cord-289926-y1rjgbui 92 15 conditions condition NNS cord-289926-y1rjgbui 92 16 . . . cord-289926-y1rjgbui 93 1 In in IN cord-289926-y1rjgbui 93 2 the the DT cord-289926-y1rjgbui 93 3 case case NN cord-289926-y1rjgbui 93 4 of of IN cord-289926-y1rjgbui 93 5 partial partial JJ cord-289926-y1rjgbui 93 6 alignments alignment NNS cord-289926-y1rjgbui 93 7 ( ( -LRB- cord-289926-y1rjgbui 93 8 Fig Fig NNP cord-289926-y1rjgbui 93 9 . . . cord-289926-y1rjgbui 93 10 2A 2A NNP cord-289926-y1rjgbui 93 11 , , , cord-289926-y1rjgbui 93 12 2C 2C NNP cord-289926-y1rjgbui 93 13 ) ) -RRB- cord-289926-y1rjgbui 94 1 the the DT cord-289926-y1rjgbui 94 2 greatest great JJS cord-289926-y1rjgbui 94 3 local local JJ cord-289926-y1rjgbui 94 4 compositional compositional JJ cord-289926-y1rjgbui 94 5 bias bias NN cord-289926-y1rjgbui 94 6 is be VBZ cord-289926-y1rjgbui 94 7 preserved preserve VBN cord-289926-y1rjgbui 94 8 , , , cord-289926-y1rjgbui 94 9 which which WDT cord-289926-y1rjgbui 94 10 makes make VBZ cord-289926-y1rjgbui 94 11 it -PRON- PRP cord-289926-y1rjgbui 94 12 a a DT cord-289926-y1rjgbui 94 13 stringent stringent JJ cord-289926-y1rjgbui 94 14 test test NN cord-289926-y1rjgbui 94 15 . . . cord-289926-y1rjgbui 95 1 This this DT cord-289926-y1rjgbui 95 2 process process NN cord-289926-y1rjgbui 95 3 was be VBD cord-289926-y1rjgbui 95 4 repeated repeat VBN cord-289926-y1rjgbui 95 5 10,000 10,000 CD cord-289926-y1rjgbui 95 6 times time NNS cord-289926-y1rjgbui 95 7 and and CC cord-289926-y1rjgbui 95 8 the the DT cord-289926-y1rjgbui 95 9 distribution distribution NN cord-289926-y1rjgbui 95 10 of of IN cord-289926-y1rjgbui 95 11 the the DT cord-289926-y1rjgbui 95 12 alignment alignment NN cord-289926-y1rjgbui 95 13 scores score NNS cord-289926-y1rjgbui 95 14 was be VBD cord-289926-y1rjgbui 95 15 examined examine VBN cord-289926-y1rjgbui 95 16 . . . cord-289926-y1rjgbui 96 1 Matches match NNS cord-289926-y1rjgbui 96 2 merely merely RB cord-289926-y1rjgbui 96 3 due due JJ cord-289926-y1rjgbui 96 4 to to IN cord-289926-y1rjgbui 96 5 compositional compositional JJ cord-289926-y1rjgbui 96 6 effects effect NNS cord-289926-y1rjgbui 96 7 alone alone RB cord-289926-y1rjgbui 96 8 should should MD cord-289926-y1rjgbui 96 9 occur occur VB cord-289926-y1rjgbui 96 10 at at IN cord-289926-y1rjgbui 96 11 equivalent equivalent JJ cord-289926-y1rjgbui 96 12 frequencies frequency NNS cord-289926-y1rjgbui 96 13 in in IN cord-289926-y1rjgbui 96 14 the the DT cord-289926-y1rjgbui 96 15 original original JJ cord-289926-y1rjgbui 96 16 and and CC cord-289926-y1rjgbui 96 17 scrambled scrambled JJ cord-289926-y1rjgbui 96 18 alignments alignment NNS cord-289926-y1rjgbui 96 19 . . . cord-289926-y1rjgbui 97 1 When when WRB cord-289926-y1rjgbui 97 2 the the DT cord-289926-y1rjgbui 97 3 alignment alignment NN cord-289926-y1rjgbui 97 4 score score NN cord-289926-y1rjgbui 97 5 of of IN cord-289926-y1rjgbui 97 6 the the DT cord-289926-y1rjgbui 97 7 original original JJ cord-289926-y1rjgbui 97 8 sequence sequence NN cord-289926-y1rjgbui 97 9 is be VBZ cord-289926-y1rjgbui 97 10 compared compare VBN cord-289926-y1rjgbui 97 11 to to IN cord-289926-y1rjgbui 97 12 the the DT cord-289926-y1rjgbui 97 13 distribution distribution NN cord-289926-y1rjgbui 97 14 of of IN cord-289926-y1rjgbui 97 15 the the DT cord-289926-y1rjgbui 97 16 scores score NNS cord-289926-y1rjgbui 97 17 of of IN cord-289926-y1rjgbui 97 18 the the DT cord-289926-y1rjgbui 97 19 scrambled scramble VBN cord-289926-y1rjgbui 97 20 sequences sequence NNS cord-289926-y1rjgbui 97 21 , , , cord-289926-y1rjgbui 97 22 Z z NN cord-289926-y1rjgbui 97 23 scores score NNS cord-289926-y1rjgbui 97 24 larger large JJR cord-289926-y1rjgbui 97 25 than than IN cord-289926-y1rjgbui 97 26 6.0 6.0 CD cord-289926-y1rjgbui 97 27 indicate indicate VBP cord-289926-y1rjgbui 97 28 that that IN cord-289926-y1rjgbui 97 29 the the DT cord-289926-y1rjgbui 97 30 original original JJ cord-289926-y1rjgbui 97 31 alignment alignment NN cord-289926-y1rjgbui 97 32 is be VBZ cord-289926-y1rjgbui 97 33 not not RB cord-289926-y1rjgbui 97 34 simply simply RB cord-289926-y1rjgbui 97 35 due due JJ cord-289926-y1rjgbui 97 36 to to IN cord-289926-y1rjgbui 97 37 compositional compositional JJ cord-289926-y1rjgbui 97 38 bias bias NN cord-289926-y1rjgbui 97 39 . . . cord-289926-y1rjgbui 98 1 A a DT cord-289926-y1rjgbui 98 2 Z z NN cord-289926-y1rjgbui 98 3 score score NN cord-289926-y1rjgbui 98 4 less less JJR cord-289926-y1rjgbui 98 5 than than IN cord-289926-y1rjgbui 98 6 3.0 3.0 CD cord-289926-y1rjgbui 98 7 indicates indicate VBZ cord-289926-y1rjgbui 98 8 that that IN cord-289926-y1rjgbui 98 9 the the DT cord-289926-y1rjgbui 98 10 similarities similarity NNS cord-289926-y1rjgbui 98 11 between between IN cord-289926-y1rjgbui 98 12 two two CD cord-289926-y1rjgbui 98 13 sequences sequence NNS cord-289926-y1rjgbui 98 14 are be VBP cord-289926-y1rjgbui 98 15 unlikely unlikely JJ cord-289926-y1rjgbui 98 16 to to TO cord-289926-y1rjgbui 98 17 be be VB cord-289926-y1rjgbui 98 18 significant significant JJ cord-289926-y1rjgbui 98 19 and and CC cord-289926-y1rjgbui 98 20 are be VBP cord-289926-y1rjgbui 98 21 probably probably RB cord-289926-y1rjgbui 98 22 due due JJ cord-289926-y1rjgbui 98 23 to to IN cord-289926-y1rjgbui 98 24 biased biased JJ cord-289926-y1rjgbui 98 25 composition composition NN cord-289926-y1rjgbui 98 26 . . . cord-289926-y1rjgbui 99 1 The the DT cord-289926-y1rjgbui 99 2 only only JJ cord-289926-y1rjgbui 99 3 potentially potentially RB cord-289926-y1rjgbui 99 4 significant significant JJ cord-289926-y1rjgbui 99 5 alignment alignment NN cord-289926-y1rjgbui 99 6 is be VBZ cord-289926-y1rjgbui 99 7 a a DT cord-289926-y1rjgbui 99 8 partial partial JJ cord-289926-y1rjgbui 99 9 alignment alignment NN cord-289926-y1rjgbui 99 10 between between IN cord-289926-y1rjgbui 99 11 the the DT cord-289926-y1rjgbui 99 12 functional functional JJ cord-289926-y1rjgbui 99 13 domains domain NNS cord-289926-y1rjgbui 99 14 of of IN cord-289926-y1rjgbui 99 15 SRY sry NN cord-289926-y1rjgbui 99 16 and and CC cord-289926-y1rjgbui 99 17 HDAg HDAg NNP cord-289926-y1rjgbui 99 18 ( ( -LRB- cord-289926-y1rjgbui 99 19 Fig Fig NNP cord-289926-y1rjgbui 99 20 . . . cord-289926-y1rjgbui 99 21 2A 2a CD cord-289926-y1rjgbui 99 22 ) ) -RRB- cord-289926-y1rjgbui 99 23 ( ( -LRB- cord-289926-y1rjgbui 99 24 Z z NN cord-289926-y1rjgbui 99 25 score score NN cord-289926-y1rjgbui 99 26 = = SYM cord-289926-y1rjgbui 99 27 6.85 6.85 CD cord-289926-y1rjgbui 99 28 ) ) -RRB- cord-289926-y1rjgbui 99 29 . . . cord-289926-y1rjgbui 100 1 The the DT cord-289926-y1rjgbui 100 2 rest rest NN cord-289926-y1rjgbui 100 3 of of IN cord-289926-y1rjgbui 100 4 the the DT cord-289926-y1rjgbui 100 5 alignments alignment NNS cord-289926-y1rjgbui 100 6 -SRY -sry VBP cord-289926-y1rjgbui 100 7 - - HYPH cord-289926-y1rjgbui 100 8 HDAg hdag JJ cord-289926-y1rjgbui 100 9 ( ( -LRB- cord-289926-y1rjgbui 100 10 long long JJ cord-289926-y1rjgbui 100 11 alignment alignment NN cord-289926-y1rjgbui 100 12 ) ) -RRB- cord-289926-y1rjgbui 100 13 , , , cord-289926-y1rjgbui 100 14 DIPA DIPA NNP cord-289926-y1rjgbui 100 15 - - HYPH cord-289926-y1rjgbui 100 16 HDAg HDAg NNP cord-289926-y1rjgbui 100 17 ( ( -LRB- cord-289926-y1rjgbui 100 18 both both DT cord-289926-y1rjgbui 100 19 alignments alignment NNS cord-289926-y1rjgbui 100 20 ) ) -RRB- cord-289926-y1rjgbui 100 21 , , , cord-289926-y1rjgbui 100 22 HDAg HDAg NNP cord-289926-y1rjgbui 100 23 - - HYPH cord-289926-y1rjgbui 100 24 rev rev NNP cord-289926-y1rjgbui 100 25 and and CC cord-289926-y1rjgbui 100 26 DIPA DIPA NNP cord-289926-y1rjgbui 100 27 - - HYPH cord-289926-y1rjgbui 100 28 rev rev NNP cord-289926-y1rjgbui 100 29 have have VBP cord-289926-y1rjgbui 100 30 Z z NN cord-289926-y1rjgbui 100 31 scores score NNS cord-289926-y1rjgbui 100 32 as as IN cord-289926-y1rjgbui 100 33 a a DT cord-289926-y1rjgbui 100 34 function function NN cord-289926-y1rjgbui 100 35 of of IN cord-289926-y1rjgbui 100 36 gap gap NN cord-289926-y1rjgbui 100 37 penalties penalty NNS cord-289926-y1rjgbui 100 38 are be VBP cord-289926-y1rjgbui 100 39 reported report VBN cord-289926-y1rjgbui 100 40 here here RB cord-289926-y1rjgbui 100 41 for for IN cord-289926-y1rjgbui 100 42 the the DT cord-289926-y1rjgbui 100 43 47 47 CD cord-289926-y1rjgbui 100 44 residue residue NN cord-289926-y1rjgbui 100 45 long long JJ cord-289926-y1rjgbui 100 46 alignment alignment NN cord-289926-y1rjgbui 100 47 of of IN cord-289926-y1rjgbui 100 48 SRY sry NN cord-289926-y1rjgbui 100 49 and and CC cord-289926-y1rjgbui 100 50 HDAg HDAg NNP cord-289926-y1rjgbui 100 51 ( ( -LRB- cord-289926-y1rjgbui 100 52 Fig Fig NNP cord-289926-y1rjgbui 100 53 . . . cord-289926-y1rjgbui 100 54 2A 2a CD cord-289926-y1rjgbui 100 55 ) ) -RRB- cord-289926-y1rjgbui 100 56 and and CC cord-289926-y1rjgbui 100 57 the the DT cord-289926-y1rjgbui 100 58 55 55 CD cord-289926-y1rjgbui 100 59 residue residue NN cord-289926-y1rjgbui 100 60 long long JJ cord-289926-y1rjgbui 100 61 alignment alignment NN cord-289926-y1rjgbui 100 62 of of IN cord-289926-y1rjgbui 100 63 DIPA DIPA NNP cord-289926-y1rjgbui 100 64 and and CC cord-289926-y1rjgbui 100 65 HDAg HDAg NNP cord-289926-y1rjgbui 100 66 ( ( -LRB- cord-289926-y1rjgbui 100 67 Fig Fig NNP cord-289926-y1rjgbui 100 68 . . . cord-289926-y1rjgbui 100 69 2C 2C NNP cord-289926-y1rjgbui 100 70 ) ) -RRB- cord-289926-y1rjgbui 100 71 . . . cord-289926-y1rjgbui 101 1 Z z NN cord-289926-y1rjgbui 101 2 scores score NNS cord-289926-y1rjgbui 101 3 were be VBD cord-289926-y1rjgbui 101 4 calculated calculate VBN cord-289926-y1rjgbui 101 5 using use VBG cord-289926-y1rjgbui 101 6 PAM PAM NNP cord-289926-y1rjgbui 101 7 150 150 CD cord-289926-y1rjgbui 101 8 comparison comparison NN cord-289926-y1rjgbui 101 9 matrix matrix NN cord-289926-y1rjgbui 101 10 . . . cord-289926-y1rjgbui 102 1 Average average JJ cord-289926-y1rjgbui 102 2 and and CC cord-289926-y1rjgbui 102 3 Standard Standard NNP cord-289926-y1rjgbui 102 4 Deviation Deviation NNP cord-289926-y1rjgbui 102 5 values value NNS cord-289926-y1rjgbui 102 6 ( ( -LRB- cord-289926-y1rjgbui 102 7 for for IN cord-289926-y1rjgbui 102 8 Z z NN cord-289926-y1rjgbui 102 9 score score NN cord-289926-y1rjgbui 102 10 calculation calculation NN cord-289926-y1rjgbui 102 11 ) ) -RRB- cord-289926-y1rjgbui 102 12 were be VBD cord-289926-y1rjgbui 102 13 based base VBN cord-289926-y1rjgbui 102 14 on on IN cord-289926-y1rjgbui 102 15 10,000 10,000 CD cord-289926-y1rjgbui 102 16 alignments alignment NNS cord-289926-y1rjgbui 102 17 per per IN cord-289926-y1rjgbui 102 18 sequence sequence NN cord-289926-y1rjgbui 102 19 . . . cord-289926-y1rjgbui 103 1 The the DT cord-289926-y1rjgbui 103 2 best good JJS cord-289926-y1rjgbui 103 3 Z z NN cord-289926-y1rjgbui 103 4 score score NN cord-289926-y1rjgbui 103 5 for for IN cord-289926-y1rjgbui 103 6 each each DT cord-289926-y1rjgbui 103 7 alignment alignment NN cord-289926-y1rjgbui 103 8 is be VBZ cord-289926-y1rjgbui 103 9 shown show VBN cord-289926-y1rjgbui 103 10 in in IN cord-289926-y1rjgbui 103 11 boldface boldface NN cord-289926-y1rjgbui 103 12 Z z NN cord-289926-y1rjgbui 103 13 score score NN cord-289926-y1rjgbui 103 14 < < XX cord-289926-y1rjgbui 103 15 6.0 6.0 CD cord-289926-y1rjgbui 103 16 in in IN cord-289926-y1rjgbui 103 17 the the DT cord-289926-y1rjgbui 103 18 Monte Monte NNP cord-289926-y1rjgbui 103 19 Carlo Carlo NNP cord-289926-y1rjgbui 103 20 analysis analysis NN cord-289926-y1rjgbui 103 21 ( ( -LRB- cord-289926-y1rjgbui 103 22 see see VB cord-289926-y1rjgbui 103 23 Fig Fig NNP cord-289926-y1rjgbui 103 24 . . NNP cord-289926-y1rjgbui 103 25 2 2 CD cord-289926-y1rjgbui 103 26 ) ) -RRB- cord-289926-y1rjgbui 103 27 . . . cord-289926-y1rjgbui 104 1 Table table NN cord-289926-y1rjgbui 104 2 1 1 CD cord-289926-y1rjgbui 104 3 reports report VBZ cord-289926-y1rjgbui 104 4 the the DT cord-289926-y1rjgbui 104 5 Z z NN cord-289926-y1rjgbui 104 6 scores score NNS cord-289926-y1rjgbui 104 7 for for IN cord-289926-y1rjgbui 104 8 the the DT cord-289926-y1rjgbui 104 9 optimized optimize VBN cord-289926-y1rjgbui 104 10 partial partial JJ cord-289926-y1rjgbui 104 11 alignments alignment NNS cord-289926-y1rjgbui 104 12 of of IN cord-289926-y1rjgbui 104 13 HDAg HDAg NNS cord-289926-y1rjgbui 104 14 with with IN cord-289926-y1rjgbui 104 15 SRY sry NN cord-289926-y1rjgbui 104 16 and and CC cord-289926-y1rjgbui 104 17 HDAg HDAg NNS cord-289926-y1rjgbui 104 18 with with IN cord-289926-y1rjgbui 104 19 DIPA DIPA NNP cord-289926-y1rjgbui 104 20 . . . cord-289926-y1rjgbui 105 1 In in IN cord-289926-y1rjgbui 105 2 all all DT cord-289926-y1rjgbui 105 3 cases case NNS cord-289926-y1rjgbui 105 4 the the DT cord-289926-y1rjgbui 105 5 SRY SRY NNP cord-289926-y1rjgbui 105 6 - - HYPH cord-289926-y1rjgbui 105 7 HDAg hdag NN cord-289926-y1rjgbui 105 8 alignment alignment NN cord-289926-y1rjgbui 105 9 is be VBZ cord-289926-y1rjgbui 105 10 much much RB cord-289926-y1rjgbui 105 11 more more RBR cord-289926-y1rjgbui 105 12 significant significant JJ cord-289926-y1rjgbui 105 13 than than IN cord-289926-y1rjgbui 105 14 the the DT cord-289926-y1rjgbui 105 15 DIPA DIPA NNP cord-289926-y1rjgbui 105 16 - - HYPH cord-289926-y1rjgbui 105 17 HDAg HDAg NNP cord-289926-y1rjgbui 105 18 alignment alignment NN cord-289926-y1rjgbui 105 19 . . . cord-289926-y1rjgbui 106 1 For for IN cord-289926-y1rjgbui 106 2 the the DT cord-289926-y1rjgbui 106 3 best good JJS cord-289926-y1rjgbui 106 4 partial partial JJ cord-289926-y1rjgbui 106 5 alignments alignment NNS cord-289926-y1rjgbui 106 6 of of IN cord-289926-y1rjgbui 106 7 SRY sry NN cord-289926-y1rjgbui 106 8 - - HYPH cord-289926-y1rjgbui 106 9 HDAg HDAg NNS cord-289926-y1rjgbui 106 10 and and CC cord-289926-y1rjgbui 106 11 DIPA DIPA NNP cord-289926-y1rjgbui 106 12 - - HYPH cord-289926-y1rjgbui 106 13 HDAg HDAg NNP cord-289926-y1rjgbui 106 14 we -PRON- PRP cord-289926-y1rjgbui 106 15 also also RB cord-289926-y1rjgbui 106 16 determined determine VBD cord-289926-y1rjgbui 106 17 the the DT cord-289926-y1rjgbui 106 18 P p NN cord-289926-y1rjgbui 106 19 - - HYPH cord-289926-y1rjgbui 106 20 value value NN cord-289926-y1rjgbui 106 21 of of IN cord-289926-y1rjgbui 106 22 the the DT cord-289926-y1rjgbui 106 23 alignment alignment NN cord-289926-y1rjgbui 106 24 . . . cord-289926-y1rjgbui 107 1 We -PRON- PRP cord-289926-y1rjgbui 107 2 plotted plot VBD cord-289926-y1rjgbui 107 3 the the DT cord-289926-y1rjgbui 107 4 log log NN cord-289926-y1rjgbui 107 5 of of IN cord-289926-y1rjgbui 107 6 the the DT cord-289926-y1rjgbui 107 7 observed observed JJ cord-289926-y1rjgbui 107 8 frequency frequency NN cord-289926-y1rjgbui 107 9 of of IN cord-289926-y1rjgbui 107 10 occurrence occurrence NN cord-289926-y1rjgbui 107 11 for for IN cord-289926-y1rjgbui 107 12 the the DT cord-289926-y1rjgbui 107 13 top top JJ cord-289926-y1rjgbui 107 14 0.05 0.05 CD cord-289926-y1rjgbui 107 15 % % NN cord-289926-y1rjgbui 107 16 of of IN cord-289926-y1rjgbui 107 17 1,000,000 1,000,000 CD cord-289926-y1rjgbui 107 18 random random JJ cord-289926-y1rjgbui 107 19 alignments alignment NNS cord-289926-y1rjgbui 107 20 as as IN cord-289926-y1rjgbui 107 21 a a DT cord-289926-y1rjgbui 107 22 function function NN cord-289926-y1rjgbui 107 23 of of IN cord-289926-y1rjgbui 107 24 their -PRON- PRP$ cord-289926-y1rjgbui 107 25 alignment alignment NN cord-289926-y1rjgbui 107 26 score score NN cord-289926-y1rjgbui 107 27 ( ( -LRB- cord-289926-y1rjgbui 107 28 Fig Fig NNP cord-289926-y1rjgbui 107 29 . . . cord-289926-y1rjgbui 107 30 4 4 CD cord-289926-y1rjgbui 107 31 ) ) -RRB- cord-289926-y1rjgbui 107 32 . . . cord-289926-y1rjgbui 108 1 The the DT cord-289926-y1rjgbui 108 2 P p NN cord-289926-y1rjgbui 108 3 - - HYPH cord-289926-y1rjgbui 108 4 value value NN cord-289926-y1rjgbui 108 5 for for IN cord-289926-y1rjgbui 108 6 the the DT cord-289926-y1rjgbui 108 7 SRY SRY NNP cord-289926-y1rjgbui 108 8 - - HYPH cord-289926-y1rjgbui 108 9 HDAg hdag NN cord-289926-y1rjgbui 108 10 partial partial JJ cord-289926-y1rjgbui 108 11 alignment alignment NN cord-289926-y1rjgbui 108 12 ( ( -LRB- cord-289926-y1rjgbui 108 13 Fig Fig NNP cord-289926-y1rjgbui 108 14 . . . cord-289926-y1rjgbui 108 15 2A 2a CD cord-289926-y1rjgbui 108 16 ) ) -RRB- cord-289926-y1rjgbui 108 17 is be VBZ cord-289926-y1rjgbui 108 18 estimated estimate VBN cord-289926-y1rjgbui 108 19 to to TO cord-289926-y1rjgbui 108 20 be be VB cord-289926-y1rjgbui 108 21 7.6 7.6 CD cord-289926-y1rjgbui 108 22 × × CD cord-289926-y1rjgbui 108 23 10 10 CD cord-289926-y1rjgbui 108 24 −7 −7 NNP cord-289926-y1rjgbui 108 25 . . . cord-289926-y1rjgbui 109 1 The the DT cord-289926-y1rjgbui 109 2 P p NN cord-289926-y1rjgbui 109 3 - - HYPH cord-289926-y1rjgbui 109 4 value value NN cord-289926-y1rjgbui 109 5 for for IN cord-289926-y1rjgbui 109 6 the the DT cord-289926-y1rjgbui 109 7 DIPA DIPA NNP cord-289926-y1rjgbui 109 8 - - HYPH cord-289926-y1rjgbui 109 9 HDAg HDAg NNP cord-289926-y1rjgbui 109 10 partial partial JJ cord-289926-y1rjgbui 109 11 alignment alignment NN cord-289926-y1rjgbui 109 12 ( ( -LRB- cord-289926-y1rjgbui 109 13 Fig Fig NNP cord-289926-y1rjgbui 109 14 . . . cord-289926-y1rjgbui 109 15 2C 2C NNP cord-289926-y1rjgbui 109 16 ) ) -RRB- cord-289926-y1rjgbui 109 17 is be VBZ cord-289926-y1rjgbui 109 18 estimated estimate VBN cord-289926-y1rjgbui 109 19 to to TO cord-289926-y1rjgbui 109 20 be be VB cord-289926-y1rjgbui 109 21 3.6 3.6 CD cord-289926-y1rjgbui 109 22 × × CD cord-289926-y1rjgbui 109 23 10 10 CD cord-289926-y1rjgbui 109 24 −4 −4 CD cord-289926-y1rjgbui 109 25 . . . cord-289926-y1rjgbui 110 1 In in IN cord-289926-y1rjgbui 110 2 this this DT cord-289926-y1rjgbui 110 3 experiment experiment NN cord-289926-y1rjgbui 110 4 326 326 CD cord-289926-y1rjgbui 110 5 out out IN cord-289926-y1rjgbui 110 6 of of IN cord-289926-y1rjgbui 110 7 1,000,000 1,000,000 CD cord-289926-y1rjgbui 110 8 random random JJ cord-289926-y1rjgbui 110 9 alignments alignment NNS cord-289926-y1rjgbui 110 10 had have VBD cord-289926-y1rjgbui 110 11 better well JJR cord-289926-y1rjgbui 110 12 scores score NNS cord-289926-y1rjgbui 110 13 than than IN cord-289926-y1rjgbui 110 14 the the DT cord-289926-y1rjgbui 110 15 proposed propose VBN cord-289926-y1rjgbui 110 16 DIPA DIPA NNP cord-289926-y1rjgbui 110 17 - - HYPH cord-289926-y1rjgbui 110 18 HDAg hdag NN cord-289926-y1rjgbui 110 19 alignment alignment NN cord-289926-y1rjgbui 110 20 ; ; : cord-289926-y1rjgbui 110 21 some some DT cord-289926-y1rjgbui 110 22 scores score NNS cord-289926-y1rjgbui 110 23 were be VBD cord-289926-y1rjgbui 110 24 significantly significantly RB cord-289926-y1rjgbui 110 25 better well JJR cord-289926-y1rjgbui 110 26 ( ( -LRB- cord-289926-y1rjgbui 110 27 5 5 CD cord-289926-y1rjgbui 110 28 alignments alignment NNS cord-289926-y1rjgbui 110 29 had have VBD cord-289926-y1rjgbui 110 30 scores score NNS cord-289926-y1rjgbui 110 31 over over IN cord-289926-y1rjgbui 110 32 50 50 CD cord-289926-y1rjgbui 110 33 , , , cord-289926-y1rjgbui 110 34 while while IN cord-289926-y1rjgbui 110 35 the the DT cord-289926-y1rjgbui 110 36 actual actual JJ cord-289926-y1rjgbui 110 37 DIPA DIPA NNP cord-289926-y1rjgbui 110 38 - - HYPH cord-289926-y1rjgbui 110 39 HDAg hdag NN cord-289926-y1rjgbui 110 40 alignment alignment NN cord-289926-y1rjgbui 110 41 had have VBD cord-289926-y1rjgbui 110 42 score score NN cord-289926-y1rjgbui 110 43 39.5 39.5 CD cord-289926-y1rjgbui 110 44 ) ) -RRB- cord-289926-y1rjgbui 110 45 . . . cord-289926-y1rjgbui 111 1 In in IN cord-289926-y1rjgbui 111 2 the the DT cord-289926-y1rjgbui 111 3 case case NN cord-289926-y1rjgbui 111 4 of of IN cord-289926-y1rjgbui 111 5 the the DT cord-289926-y1rjgbui 111 6 SRY SRY NNP cord-289926-y1rjgbui 111 7 - - HYPH cord-289926-y1rjgbui 111 8 HDAg hdag NN cord-289926-y1rjgbui 111 9 alignment alignment NN cord-289926-y1rjgbui 111 10 , , , cord-289926-y1rjgbui 111 11 none none NN cord-289926-y1rjgbui 111 12 of of IN cord-289926-y1rjgbui 111 13 the the DT cord-289926-y1rjgbui 111 14 1,000,000 1,000,000 CD cord-289926-y1rjgbui 111 15 random random JJ cord-289926-y1rjgbui 111 16 alignments alignment NNS cord-289926-y1rjgbui 111 17 exceeded exceed VBD cord-289926-y1rjgbui 111 18 the the DT cord-289926-y1rjgbui 111 19 reported reported JJ cord-289926-y1rjgbui 111 20 score score NN cord-289926-y1rjgbui 111 21 of of IN cord-289926-y1rjgbui 111 22 47.8 47.8 CD cord-289926-y1rjgbui 111 23 ( ( -LRB- cord-289926-y1rjgbui 111 24 the the DT cord-289926-y1rjgbui 111 25 highest high JJS cord-289926-y1rjgbui 111 26 random random JJ cord-289926-y1rjgbui 111 27 score score NN cord-289926-y1rjgbui 111 28 was be VBD cord-289926-y1rjgbui 111 29 45.9 45.9 CD cord-289926-y1rjgbui 111 30 ) ) -RRB- cord-289926-y1rjgbui 111 31 . . . cord-289926-y1rjgbui 112 1 Testing test VBG cord-289926-y1rjgbui 112 2 for for IN cord-289926-y1rjgbui 112 3 frameshifting frameshifte VBG cord-289926-y1rjgbui 112 4 during during IN cord-289926-y1rjgbui 112 5 translation translation NN cord-289926-y1rjgbui 113 1 SRY sry UH cord-289926-y1rjgbui 113 2 protein protein NN cord-289926-y1rjgbui 113 3 was be VBD cord-289926-y1rjgbui 113 4 aligned align VBN cord-289926-y1rjgbui 113 5 to to IN cord-289926-y1rjgbui 113 6 the the DT cord-289926-y1rjgbui 113 7 HDV HDV NNP cord-289926-y1rjgbui 113 8 genome genome NN cord-289926-y1rjgbui 113 9 in in IN cord-289926-y1rjgbui 113 10 all all DT cord-289926-y1rjgbui 113 11 6 6 CD cord-289926-y1rjgbui 113 12 reading reading NN cord-289926-y1rjgbui 113 13 frames frame NNS cord-289926-y1rjgbui 113 14 . . . cord-289926-y1rjgbui 114 1 As as IN cord-289926-y1rjgbui 114 2 expected expect VBN cord-289926-y1rjgbui 114 3 , , , cord-289926-y1rjgbui 114 4 the the DT cord-289926-y1rjgbui 114 5 significant significant JJ cord-289926-y1rjgbui 114 6 alignment alignment NN cord-289926-y1rjgbui 114 7 is be VBZ cord-289926-y1rjgbui 114 8 found find VBN cord-289926-y1rjgbui 114 9 on on IN cord-289926-y1rjgbui 114 10 the the DT cord-289926-y1rjgbui 114 11 antisense antisense NN cord-289926-y1rjgbui 114 12 strand strand NN cord-289926-y1rjgbui 114 13 . . . cord-289926-y1rjgbui 115 1 There there EX cord-289926-y1rjgbui 115 2 is be VBZ cord-289926-y1rjgbui 115 3 no no DT cord-289926-y1rjgbui 115 4 potential potential JJ cord-289926-y1rjgbui 115 5 _SP cord-289926-y1rjgbui 116 1 The the DT cord-289926-y1rjgbui 116 2 discovery discovery NN cord-289926-y1rjgbui 116 3 of of IN cord-289926-y1rjgbui 116 4 sequence sequence NN cord-289926-y1rjgbui 116 5 similarity similarity NN cord-289926-y1rjgbui 116 6 between between IN cord-289926-y1rjgbui 116 7 the the DT cord-289926-y1rjgbui 116 8 RNA RNA NNP cord-289926-y1rjgbui 116 9 - - HYPH cord-289926-y1rjgbui 116 10 binding bind VBG cord-289926-y1rjgbui 116 11 domain domain NN cord-289926-y1rjgbui 116 12 of of IN cord-289926-y1rjgbui 116 13 HDAg hdag NN cord-289926-y1rjgbui 116 14 and and CC cord-289926-y1rjgbui 116 15 the the DT cord-289926-y1rjgbui 116 16 HMG HMG NNP cord-289926-y1rjgbui 116 17 box box NN cord-289926-y1rjgbui 116 18 of of IN cord-289926-y1rjgbui 116 19 SRY SRY NNP cord-289926-y1rjgbui 116 20 suggests suggest VBZ cord-289926-y1rjgbui 116 21 a a DT cord-289926-y1rjgbui 116 22 possible possible JJ cord-289926-y1rjgbui 116 23 evolutionary evolutionary JJ cord-289926-y1rjgbui 116 24 relationship relationship NN cord-289926-y1rjgbui 116 25 between between IN cord-289926-y1rjgbui 116 26 the the DT cord-289926-y1rjgbui 116 27 HMG HMG NNP cord-289926-y1rjgbui 116 28 box box NN cord-289926-y1rjgbui 116 29 , , , cord-289926-y1rjgbui 116 30 a a DT cord-289926-y1rjgbui 116 31 DNA dna NN cord-289926-y1rjgbui 116 32 - - HYPH cord-289926-y1rjgbui 116 33 binding bind VBG cord-289926-y1rjgbui 116 34 domain domain NN cord-289926-y1rjgbui 116 35 , , , cord-289926-y1rjgbui 116 36 and and CC cord-289926-y1rjgbui 116 37 the the DT cord-289926-y1rjgbui 116 38 RNA RNA NNP cord-289926-y1rjgbui 116 39 - - HYPH cord-289926-y1rjgbui 116 40 binding bind VBG cord-289926-y1rjgbui 116 41 domain domain NN cord-289926-y1rjgbui 116 42 of of IN cord-289926-y1rjgbui 116 43 HDAg HDAg NNS cord-289926-y1rjgbui 116 44 . . . cord-289926-y1rjgbui 117 1 For for IN cord-289926-y1rjgbui 117 2 the the DT cord-289926-y1rjgbui 117 3 sake sake NN cord-289926-y1rjgbui 117 4 of of IN cord-289926-y1rjgbui 117 5 clarity clarity NN cord-289926-y1rjgbui 117 6 we -PRON- PRP cord-289926-y1rjgbui 117 7 will will MD cord-289926-y1rjgbui 117 8 discuss discuss VB cord-289926-y1rjgbui 117 9 the the DT cord-289926-y1rjgbui 117 10 relationship relationship NN cord-289926-y1rjgbui 117 11 between between IN cord-289926-y1rjgbui 117 12 HDAg HDAg NNS cord-289926-y1rjgbui 117 13 and and CC cord-289926-y1rjgbui 117 14 SRY sry UH cord-289926-y1rjgbui 117 15 , , , cord-289926-y1rjgbui 117 16 but but CC cord-289926-y1rjgbui 117 17 the the DT cord-289926-y1rjgbui 117 18 same same JJ cord-289926-y1rjgbui 117 19 argument argument NN cord-289926-y1rjgbui 117 20 could could MD cord-289926-y1rjgbui 117 21 apply apply VB cord-289926-y1rjgbui 117 22 to to IN cord-289926-y1rjgbui 117 23 SOX3 SOX3 NNP cord-289926-y1rjgbui 117 24 and and CC cord-289926-y1rjgbui 117 25 , , , cord-289926-y1rjgbui 117 26 possibly possibly RB cord-289926-y1rjgbui 117 27 , , , cord-289926-y1rjgbui 117 28 to to IN cord-289926-y1rjgbui 117 29 other other JJ cord-289926-y1rjgbui 117 30 SRY sry NN cord-289926-y1rjgbui 117 31 - - HYPH cord-289926-y1rjgbui 117 32 related relate VBN cord-289926-y1rjgbui 117 33 genes gene NNS cord-289926-y1rjgbui 117 34 . . . cord-289926-y1rjgbui 118 1 Statistically statistically RB cord-289926-y1rjgbui 118 2 significant significant JJ cord-289926-y1rjgbui 118 3 sequence sequence NN cord-289926-y1rjgbui 118 4 similarities similarity NNS cord-289926-y1rjgbui 118 5 are be VBP cord-289926-y1rjgbui 118 6 limited limit VBN cord-289926-y1rjgbui 118 7 to to IN cord-289926-y1rjgbui 118 8 the the DT cord-289926-y1rjgbui 118 9 functionally functionally RB cord-289926-y1rjgbui 118 10 essential essential JJ cord-289926-y1rjgbui 118 11 regions region NNS cord-289926-y1rjgbui 118 12 of of IN cord-289926-y1rjgbui 118 13 both both DT cord-289926-y1rjgbui 118 14 genes gene NNS cord-289926-y1rjgbui 118 15 : : : cord-289926-y1rjgbui 118 16 in in IN cord-289926-y1rjgbui 118 17 the the DT cord-289926-y1rjgbui 118 18 SRY SRY NNP cord-289926-y1rjgbui 118 19 gene gene NN cord-289926-y1rjgbui 118 20 the the DT cord-289926-y1rjgbui 118 21 similarity similarity NN cord-289926-y1rjgbui 118 22 is be VBZ cord-289926-y1rjgbui 118 23 confined confine VBN cord-289926-y1rjgbui 118 24 to to IN cord-289926-y1rjgbui 118 25 the the DT cord-289926-y1rjgbui 118 26 HMG HMG NNP cord-289926-y1rjgbui 118 27 ( ( -LRB- cord-289926-y1rjgbui 118 28 High High NNP cord-289926-y1rjgbui 118 29 Mobility Mobility NNP cord-289926-y1rjgbui 118 30 Group Group NNP cord-289926-y1rjgbui 118 31 ) ) -RRB- cord-289926-y1rjgbui 118 32 box box NN cord-289926-y1rjgbui 118 33 , , , cord-289926-y1rjgbui 118 34 a a DT cord-289926-y1rjgbui 118 35 DNA dna NN cord-289926-y1rjgbui 118 36 binding binding NN cord-289926-y1rjgbui 118 37 motif motif NN cord-289926-y1rjgbui 118 38 found find VBN cord-289926-y1rjgbui 118 39 in in IN cord-289926-y1rjgbui 118 40 the the DT cord-289926-y1rjgbui 118 41 HMG HMG NNP cord-289926-y1rjgbui 118 42 protein protein NN cord-289926-y1rjgbui 118 43 superfamily superfamily NN cord-289926-y1rjgbui 118 44 [ [ -LRB- cord-289926-y1rjgbui 118 45 24 24 CD cord-289926-y1rjgbui 118 46 , , , cord-289926-y1rjgbui 118 47 31 31 CD cord-289926-y1rjgbui 118 48 ] ] -RRB- cord-289926-y1rjgbui 118 49 , , , cord-289926-y1rjgbui 118 50 in in IN cord-289926-y1rjgbui 118 51 HDAg hdag FW cord-289926-y1rjgbui 118 52 the the DT cord-289926-y1rjgbui 118 53 similarity similarity NN cord-289926-y1rjgbui 118 54 is be VBZ cord-289926-y1rjgbui 118 55 limited limit VBN cord-289926-y1rjgbui 118 56 to to IN cord-289926-y1rjgbui 118 57 RNA rna NN cord-289926-y1rjgbui 118 58 - - HYPH cord-289926-y1rjgbui 118 59 binding bind VBG cord-289926-y1rjgbui 118 60 domain domain NN cord-289926-y1rjgbui 118 61 . . . cord-289926-y1rjgbui 119 1 SRY sry UH cord-289926-y1rjgbui 119 2 , , , cord-289926-y1rjgbui 119 3 HDAg HDAg NNS cord-289926-y1rjgbui 119 4 and and CC cord-289926-y1rjgbui 119 5 DIPA DIPA NNP cord-289926-y1rjgbui 119 6 are be VBP cord-289926-y1rjgbui 119 7 bZIP bZIP VBG cord-289926-y1rjgbui 119 8 proteins protein NNS cord-289926-y1rjgbui 119 9 -they -they CD cord-289926-y1rjgbui 120 1 thus thus RB cord-289926-y1rjgbui 120 2 possess possess VB cord-289926-y1rjgbui 120 3 a a DT cord-289926-y1rjgbui 120 4 strong strong JJ cord-289926-y1rjgbui 120 5 compositional compositional JJ cord-289926-y1rjgbui 120 6 bias bias NN cord-289926-y1rjgbui 120 7 , , , cord-289926-y1rjgbui 120 8 which which WDT cord-289926-y1rjgbui 120 9 influences influence VBZ cord-289926-y1rjgbui 120 10 sequence sequence NN cord-289926-y1rjgbui 120 11 analyses analysis NNS cord-289926-y1rjgbui 120 12 . . . cord-289926-y1rjgbui 121 1 This this DT cord-289926-y1rjgbui 121 2 compositional compositional JJ cord-289926-y1rjgbui 121 3 bias bias NN cord-289926-y1rjgbui 121 4 may may MD cord-289926-y1rjgbui 121 5 reflect reflect VB cord-289926-y1rjgbui 121 6 structural structural JJ cord-289926-y1rjgbui 121 7 and and CC cord-289926-y1rjgbui 121 8 functional functional JJ cord-289926-y1rjgbui 121 9 constrains constrain NNS cord-289926-y1rjgbui 121 10 placed place VBN cord-289926-y1rjgbui 121 11 upon upon IN cord-289926-y1rjgbui 121 12 the the DT cord-289926-y1rjgbui 121 13 RNA RNA NNP cord-289926-y1rjgbui 121 14 or or CC cord-289926-y1rjgbui 121 15 DNA dna NN cord-289926-y1rjgbui 121 16 - - HYPH cord-289926-y1rjgbui 121 17 binding bind VBG cord-289926-y1rjgbui 121 18 domain domain NN cord-289926-y1rjgbui 121 19 , , , cord-289926-y1rjgbui 121 20 and and CC cord-289926-y1rjgbui 121 21 could could MD cord-289926-y1rjgbui 121 22 therefore therefore RB cord-289926-y1rjgbui 121 23 suggest suggest VB cord-289926-y1rjgbui 121 24 sequence sequence NN cord-289926-y1rjgbui 121 25 convergence convergence NN cord-289926-y1rjgbui 121 26 rather rather RB cord-289926-y1rjgbui 121 27 than than IN cord-289926-y1rjgbui 121 28 a a DT cord-289926-y1rjgbui 121 29 common common JJ cord-289926-y1rjgbui 121 30 evolutionary evolutionary JJ cord-289926-y1rjgbui 121 31 origin origin NN cord-289926-y1rjgbui 121 32 . . . cord-289926-y1rjgbui 122 1 Thus thus RB cord-289926-y1rjgbui 122 2 the the DT cord-289926-y1rjgbui 122 3 high high JJ cord-289926-y1rjgbui 122 4 values value NNS cord-289926-y1rjgbui 122 5 for for IN cord-289926-y1rjgbui 122 6 percent percent NN cord-289926-y1rjgbui 122 7 identity identity NN cord-289926-y1rjgbui 122 8 and and CC cord-289926-y1rjgbui 122 9 similarity similarity NN cord-289926-y1rjgbui 122 10 in in IN cord-289926-y1rjgbui 122 11 compositionally compositionally RB cord-289926-y1rjgbui 122 12 biased biased JJ cord-289926-y1rjgbui 122 13 alignments alignment NNS cord-289926-y1rjgbui 122 14 are be VBP cord-289926-y1rjgbui 122 15 less less RBR cord-289926-y1rjgbui 122 16 significant significant JJ cord-289926-y1rjgbui 122 17 than than IN cord-289926-y1rjgbui 122 18 in in IN cord-289926-y1rjgbui 122 19 compositionally compositionally RB cord-289926-y1rjgbui 122 20 unbiased unbiased JJ cord-289926-y1rjgbui 122 21 sequences sequence NNS cord-289926-y1rjgbui 122 22 . . . cord-289926-y1rjgbui 123 1 To to TO cord-289926-y1rjgbui 123 2 address address VB cord-289926-y1rjgbui 123 3 the the DT cord-289926-y1rjgbui 123 4 effects effect NNS cord-289926-y1rjgbui 123 5 of of IN cord-289926-y1rjgbui 123 6 the the DT cord-289926-y1rjgbui 123 7 local local JJ cord-289926-y1rjgbui 123 8 compositional compositional JJ cord-289926-y1rjgbui 123 9 bias bias NN cord-289926-y1rjgbui 123 10 we -PRON- PRP cord-289926-y1rjgbui 123 11 used use VBD cord-289926-y1rjgbui 123 12 a a DT cord-289926-y1rjgbui 123 13 Monte Monte NNP cord-289926-y1rjgbui 123 14 Carlo Carlo NNP cord-289926-y1rjgbui 123 15 analysis analysis NN cord-289926-y1rjgbui 123 16 -a -a NN cord-289926-y1rjgbui 123 17 process process NN cord-289926-y1rjgbui 123 18 that that WDT cord-289926-y1rjgbui 123 19 compares compare VBZ cord-289926-y1rjgbui 123 20 the the DT cord-289926-y1rjgbui 123 21 alignment alignment NN cord-289926-y1rjgbui 123 22 of of IN cord-289926-y1rjgbui 123 23 interest interest NN cord-289926-y1rjgbui 123 24 with with IN cord-289926-y1rjgbui 123 25 alignments alignment NNS cord-289926-y1rjgbui 123 26 of of IN cord-289926-y1rjgbui 123 27 the the DT cord-289926-y1rjgbui 123 28 randomly randomly RB cord-289926-y1rjgbui 123 29 generated generate VBN cord-289926-y1rjgbui 123 30 sequences sequence NNS cord-289926-y1rjgbui 123 31 of of IN cord-289926-y1rjgbui 123 32 the the DT cord-289926-y1rjgbui 123 33 same same JJ cord-289926-y1rjgbui 123 34 composition composition NN cord-289926-y1rjgbui 123 35 . . . cord-289926-y1rjgbui 124 1 Z z NN cord-289926-y1rjgbui 124 2 scores score NNS cord-289926-y1rjgbui 124 3 above above IN cord-289926-y1rjgbui 124 4 6.0 6.0 CD cord-289926-y1rjgbui 124 5 indicate indicate VBP cord-289926-y1rjgbui 124 6 that that IN cord-289926-y1rjgbui 124 7 the the DT cord-289926-y1rjgbui 124 8 alignment alignment NN cord-289926-y1rjgbui 124 9 of of IN cord-289926-y1rjgbui 124 10 interest interest NN cord-289926-y1rjgbui 124 11 supports support VBZ cord-289926-y1rjgbui 124 12 the the DT cord-289926-y1rjgbui 124 13 inference inference NN cord-289926-y1rjgbui 124 14 of of IN cord-289926-y1rjgbui 124 15 homology homology NN cord-289926-y1rjgbui 124 16 in in IN cord-289926-y1rjgbui 124 17 spite spite NN cord-289926-y1rjgbui 124 18 of of IN cord-289926-y1rjgbui 124 19 compositional compositional JJ cord-289926-y1rjgbui 124 20 biases bias NNS cord-289926-y1rjgbui 124 21 . . . cord-289926-y1rjgbui 125 1 The the DT cord-289926-y1rjgbui 125 2 high high JJ cord-289926-y1rjgbui 125 3 Z z NN cord-289926-y1rjgbui 125 4 score score NN cord-289926-y1rjgbui 125 5 ( ( -LRB- cord-289926-y1rjgbui 125 6 Z z NN cord-289926-y1rjgbui 125 7 score score NN cord-289926-y1rjgbui 125 8 = = SYM cord-289926-y1rjgbui 125 9 6.85 6.85 CD cord-289926-y1rjgbui 125 10 ) ) -RRB- cord-289926-y1rjgbui 125 11 of of IN cord-289926-y1rjgbui 125 12 SRY SRY NNP cord-289926-y1rjgbui 125 13 - - HYPH cord-289926-y1rjgbui 125 14 HDAg hdag NN cord-289926-y1rjgbui 125 15 alignment alignment NN cord-289926-y1rjgbui 125 16 argues argue VBZ cord-289926-y1rjgbui 125 17 that that IN cord-289926-y1rjgbui 125 18 the the DT cord-289926-y1rjgbui 125 19 HDAg hdag NN cord-289926-y1rjgbui 125 20 sequence sequence NN cord-289926-y1rjgbui 125 21 is be VBZ cord-289926-y1rjgbui 125 22 more more RBR cord-289926-y1rjgbui 125 23 similar similar JJ cord-289926-y1rjgbui 125 24 to to IN cord-289926-y1rjgbui 125 25 the the DT cord-289926-y1rjgbui 125 26 HMG HMG NNP cord-289926-y1rjgbui 125 27 domain domain NN cord-289926-y1rjgbui 125 28 of of IN cord-289926-y1rjgbui 125 29 SRY sry NN cord-289926-y1rjgbui 125 30 than than IN cord-289926-y1rjgbui 125 31 to to IN cord-289926-y1rjgbui 125 32 any any DT cord-289926-y1rjgbui 125 33 randomly randomly RB cord-289926-y1rjgbui 125 34 assembled assemble VBN cord-289926-y1rjgbui 125 35 sequences sequence NNS cord-289926-y1rjgbui 125 36 of of IN cord-289926-y1rjgbui 125 37 the the DT cord-289926-y1rjgbui 125 38 same same JJ cord-289926-y1rjgbui 125 39 composition composition NN cord-289926-y1rjgbui 125 40 . . . cord-289926-y1rjgbui 126 1 Therefore therefore RB cord-289926-y1rjgbui 126 2 , , , cord-289926-y1rjgbui 126 3 the the DT cord-289926-y1rjgbui 126 4 compositional compositional JJ cord-289926-y1rjgbui 126 5 constraints constraint NNS cord-289926-y1rjgbui 126 6 alone alone RB cord-289926-y1rjgbui 126 7 upon upon IN cord-289926-y1rjgbui 126 8 the the DT cord-289926-y1rjgbui 126 9 functional functional JJ cord-289926-y1rjgbui 126 10 domain domain NN cord-289926-y1rjgbui 126 11 can can MD cord-289926-y1rjgbui 126 12 not not RB cord-289926-y1rjgbui 126 13 explain explain VB cord-289926-y1rjgbui 126 14 the the DT cord-289926-y1rjgbui 126 15 observed observed JJ cord-289926-y1rjgbui 126 16 level level NN cord-289926-y1rjgbui 126 17 of of IN cord-289926-y1rjgbui 126 18 sequence sequence NN cord-289926-y1rjgbui 126 19 similarity similarity NN cord-289926-y1rjgbui 126 20 between between IN cord-289926-y1rjgbui 126 21 HMG HMG NNP cord-289926-y1rjgbui 126 22 domain domain NN cord-289926-y1rjgbui 126 23 of of IN cord-289926-y1rjgbui 126 24 SRY sry NN cord-289926-y1rjgbui 126 25 and and CC cord-289926-y1rjgbui 126 26 HDAg hdag NN cord-289926-y1rjgbui 126 27 . . . cord-289926-y1rjgbui 127 1 While while IN cord-289926-y1rjgbui 127 2 it -PRON- PRP cord-289926-y1rjgbui 127 3 is be VBZ cord-289926-y1rjgbui 127 4 possible possible JJ cord-289926-y1rjgbui 127 5 that that IN cord-289926-y1rjgbui 127 6 the the DT cord-289926-y1rjgbui 127 7 unusual unusual JJ cord-289926-y1rjgbui 127 8 degree degree NN cord-289926-y1rjgbui 127 9 of of IN cord-289926-y1rjgbui 127 10 sequence sequence NN cord-289926-y1rjgbui 127 11 similarity similarity NN cord-289926-y1rjgbui 127 12 is be VBZ cord-289926-y1rjgbui 127 13 due due JJ cord-289926-y1rjgbui 127 14 to to IN cord-289926-y1rjgbui 127 15 convergent convergent JJ cord-289926-y1rjgbui 127 16 evolution evolution NN cord-289926-y1rjgbui 127 17 to to IN cord-289926-y1rjgbui 127 18 an an DT cord-289926-y1rjgbui 127 19 energetically energetically RB cord-289926-y1rjgbui 127 20 favorable favorable JJ cord-289926-y1rjgbui 127 21 nucleic nucleic JJ cord-289926-y1rjgbui 127 22 acid acid NN cord-289926-y1rjgbui 127 23 binding bind VBG cord-289926-y1rjgbui 127 24 structure structure NN cord-289926-y1rjgbui 127 25 , , , cord-289926-y1rjgbui 127 26 one one PRP cord-289926-y1rjgbui 127 27 must must MD cord-289926-y1rjgbui 127 28 keep keep VB cord-289926-y1rjgbui 127 29 in in IN cord-289926-y1rjgbui 127 30 mind mind NN cord-289926-y1rjgbui 127 31 that that IN cord-289926-y1rjgbui 127 32 there there EX cord-289926-y1rjgbui 127 33 are be VBP cord-289926-y1rjgbui 127 34 a a DT cord-289926-y1rjgbui 127 35 nearly nearly RB cord-289926-y1rjgbui 127 36 unlimited unlimited JJ cord-289926-y1rjgbui 127 37 number number NN cord-289926-y1rjgbui 127 38 of of IN cord-289926-y1rjgbui 127 39 ways way NNS cord-289926-y1rjgbui 127 40 to to TO cord-289926-y1rjgbui 127 41 create create VB cord-289926-y1rjgbui 127 42 a a DT cord-289926-y1rjgbui 127 43 polypeptide polypeptide NN cord-289926-y1rjgbui 127 44 that that WDT cord-289926-y1rjgbui 127 45 will will MD cord-289926-y1rjgbui 127 46 fold fold VB cord-289926-y1rjgbui 127 47 into into IN cord-289926-y1rjgbui 127 48 a a DT cord-289926-y1rjgbui 127 49 given give VBN cord-289926-y1rjgbui 127 50 three three CD cord-289926-y1rjgbui 127 51 - - HYPH cord-289926-y1rjgbui 127 52 dimensional dimensional JJ cord-289926-y1rjgbui 127 53 shape shape NN cord-289926-y1rjgbui 127 54 . . . cord-289926-y1rjgbui 128 1 Therefore therefore RB cord-289926-y1rjgbui 128 2 there there EX cord-289926-y1rjgbui 128 3 is be VBZ cord-289926-y1rjgbui 128 4 no no DT cord-289926-y1rjgbui 128 5 a a FW cord-289926-y1rjgbui 128 6 priori priori JJ cord-289926-y1rjgbui 128 7 reason reason NN cord-289926-y1rjgbui 128 8 that that IN cord-289926-y1rjgbui 128 9 unrelated unrelated JJ cord-289926-y1rjgbui 128 10 molecules molecule NNS cord-289926-y1rjgbui 128 11 should should MD cord-289926-y1rjgbui 128 12 show show VB cord-289926-y1rjgbui 128 13 significant significant JJ cord-289926-y1rjgbui 128 14 similarity similarity NN cord-289926-y1rjgbui 128 15 or or CC cord-289926-y1rjgbui 128 16 similar similar JJ cord-289926-y1rjgbui 128 17 spacing spacing NN cord-289926-y1rjgbui 128 18 of of IN cord-289926-y1rjgbui 128 19 conserved conserved JJ cord-289926-y1rjgbui 128 20 residues residue NNS cord-289926-y1rjgbui 128 21 in in IN cord-289926-y1rjgbui 128 22 the the DT cord-289926-y1rjgbui 128 23 absence absence NN cord-289926-y1rjgbui 128 24 of of IN cord-289926-y1rjgbui 128 25 an an DT cord-289926-y1rjgbui 128 26 ancestral ancestral JJ cord-289926-y1rjgbui 128 27 relationship relationship NN cord-289926-y1rjgbui 128 28 . . . cord-289926-y1rjgbui 129 1 See see VB cord-289926-y1rjgbui 129 2 Patterson Patterson NNP cord-289926-y1rjgbui 129 3 [ [ -LRB- cord-289926-y1rjgbui 129 4 36 36 CD cord-289926-y1rjgbui 129 5 ] ] -RRB- cord-289926-y1rjgbui 129 6 for for IN cord-289926-y1rjgbui 129 7 a a DT cord-289926-y1rjgbui 129 8 more more RBR cord-289926-y1rjgbui 129 9 complete complete JJ cord-289926-y1rjgbui 129 10 development development NN cord-289926-y1rjgbui 129 11 of of IN cord-289926-y1rjgbui 129 12 this this DT cord-289926-y1rjgbui 129 13 argument argument NN cord-289926-y1rjgbui 129 14 . . . cord-289926-y1rjgbui 130 1 None none NN cord-289926-y1rjgbui 130 2 of of IN cord-289926-y1rjgbui 130 3 the the DT cord-289926-y1rjgbui 130 4 alignments alignment NNS cord-289926-y1rjgbui 130 5 between between IN cord-289926-y1rjgbui 130 6 DIPA DIPA NNP cord-289926-y1rjgbui 130 7 and and CC cord-289926-y1rjgbui 130 8 HDAg HDAg NNPS cord-289926-y1rjgbui 130 9 were be VBD cord-289926-y1rjgbui 130 10 found find VBN cord-289926-y1rjgbui 130 11 to to TO cord-289926-y1rjgbui 130 12 be be VB cord-289926-y1rjgbui 130 13 statistically statistically RB cord-289926-y1rjgbui 130 14 significant significant JJ cord-289926-y1rjgbui 130 15 based base VBN cord-289926-y1rjgbui 130 16 on on IN cord-289926-y1rjgbui 130 17 a a DT cord-289926-y1rjgbui 130 18 Monte Monte NNP cord-289926-y1rjgbui 130 19 Carlo Carlo NNP cord-289926-y1rjgbui 130 20 analysis analysis NN cord-289926-y1rjgbui 130 21 . . . cord-289926-y1rjgbui 131 1 The the DT cord-289926-y1rjgbui 131 2 best good JJS cord-289926-y1rjgbui 131 3 Z z NN cord-289926-y1rjgbui 131 4 score score NN cord-289926-y1rjgbui 131 5 for for IN cord-289926-y1rjgbui 131 6 an an DT cord-289926-y1rjgbui 131 7 alignment alignment NN cord-289926-y1rjgbui 131 8 is be VBZ cord-289926-y1rjgbui 131 9 4.68 4.68 CD cord-289926-y1rjgbui 131 10 ; ; : cord-289926-y1rjgbui 131 11 it -PRON- PRP cord-289926-y1rjgbui 131 12 corresponds correspond VBZ cord-289926-y1rjgbui 131 13 to to IN cord-289926-y1rjgbui 131 14 the the DT cord-289926-y1rjgbui 131 15 partial partial JJ cord-289926-y1rjgbui 131 16 alignment alignment NN cord-289926-y1rjgbui 131 17 between between IN cord-289926-y1rjgbui 131 18 the the DT cord-289926-y1rjgbui 131 19 55-residue 55-residue CD cord-289926-y1rjgbui 131 20 long long JJ cord-289926-y1rjgbui 131 21 central central JJ cord-289926-y1rjgbui 131 22 domain domain NN cord-289926-y1rjgbui 131 23 of of IN cord-289926-y1rjgbui 131 24 DIPA DIPA NNP cord-289926-y1rjgbui 131 25 and and CC cord-289926-y1rjgbui 131 26 RNA RNA NNP cord-289926-y1rjgbui 131 27 - - HYPH cord-289926-y1rjgbui 131 28 binding bind VBG cord-289926-y1rjgbui 131 29 domain domain NN cord-289926-y1rjgbui 131 30 of of IN cord-289926-y1rjgbui 131 31 HDAg hdag NN cord-289926-y1rjgbui 131 32 ( ( -LRB- cord-289926-y1rjgbui 131 33 Fig Fig NNP cord-289926-y1rjgbui 131 34 . . . cord-289926-y1rjgbui 131 35 2C 2C NNP cord-289926-y1rjgbui 131 36 ) ) -RRB- cord-289926-y1rjgbui 131 37 . . . cord-289926-y1rjgbui 132 1 The the DT cord-289926-y1rjgbui 132 2 P p NN cord-289926-y1rjgbui 132 3 - - HYPH cord-289926-y1rjgbui 132 4 value value NN cord-289926-y1rjgbui 132 5 of of IN cord-289926-y1rjgbui 132 6 this this DT cord-289926-y1rjgbui 132 7 alignment alignment NN cord-289926-y1rjgbui 132 8 is be VBZ cord-289926-y1rjgbui 132 9 estimated estimate VBN cord-289926-y1rjgbui 132 10 to to TO cord-289926-y1rjgbui 132 11 be be VB cord-289926-y1rjgbui 132 12 3.6 3.6 CD cord-289926-y1rjgbui 132 13 × × CD cord-289926-y1rjgbui 132 14 10 10 CD cord-289926-y1rjgbui 132 15 −4 −4 CD cord-289926-y1rjgbui 132 16 ( ( -LRB- cord-289926-y1rjgbui 132 17 Fig Fig NNP cord-289926-y1rjgbui 132 18 . . . cord-289926-y1rjgbui 132 19 4 4 CD cord-289926-y1rjgbui 132 20 ) ) -RRB- cord-289926-y1rjgbui 132 21 . . . cord-289926-y1rjgbui 133 1 The the DT cord-289926-y1rjgbui 133 2 E e NN cord-289926-y1rjgbui 133 3 - - NN cord-289926-y1rjgbui 133 4 value value NN cord-289926-y1rjgbui 133 5 ( ( -LRB- cord-289926-y1rjgbui 133 6 expected expect VBN cord-289926-y1rjgbui 133 7 number number NN cord-289926-y1rjgbui 133 8 of of IN cord-289926-y1rjgbui 133 9 comparisons comparison NNS cord-289926-y1rjgbui 133 10 achieving achieve VBG cord-289926-y1rjgbui 133 11 an an DT cord-289926-y1rjgbui 133 12 equal equal JJ cord-289926-y1rjgbui 133 13 or or CC cord-289926-y1rjgbui 133 14 higher high JJR cord-289926-y1rjgbui 133 15 score score NN cord-289926-y1rjgbui 133 16 in in IN cord-289926-y1rjgbui 133 17 an an DT cord-289926-y1rjgbui 133 18 equivalent equivalent JJ cord-289926-y1rjgbui 133 19 database database NN cord-289926-y1rjgbui 133 20 search search NN cord-289926-y1rjgbui 133 21 ) ) -RRB- cord-289926-y1rjgbui 133 22 for for IN cord-289926-y1rjgbui 133 23 this this DT cord-289926-y1rjgbui 133 24 alignment alignment NN cord-289926-y1rjgbui 133 25 is be VBZ cord-289926-y1rjgbui 133 26 25 25 CD cord-289926-y1rjgbui 133 27 for for IN cord-289926-y1rjgbui 133 28 a a DT cord-289926-y1rjgbui 133 29 69,000 69,000 CD cord-289926-y1rjgbui 133 30 sequences sequence NNS cord-289926-y1rjgbui 133 31 database database NN cord-289926-y1rjgbui 133 32 ( ( -LRB- cord-289926-y1rjgbui 133 33 size size NN cord-289926-y1rjgbui 133 34 of of IN cord-289926-y1rjgbui 133 35 the the DT cord-289926-y1rjgbui 133 36 latest late JJS cord-289926-y1rjgbui 133 37 SWISS swiss JJ cord-289926-y1rjgbui 133 38 - - HYPH cord-289926-y1rjgbui 133 39 PROT prot NN cord-289926-y1rjgbui 133 40 database database NN cord-289926-y1rjgbui 133 41 , , , cord-289926-y1rjgbui 133 42 release release VB cord-289926-y1rjgbui 133 43 35 35 CD cord-289926-y1rjgbui 133 44 ) ) -RRB- cord-289926-y1rjgbui 133 45 . . . cord-289926-y1rjgbui 134 1 This this DT cord-289926-y1rjgbui 134 2 E e NN cord-289926-y1rjgbui 134 3 - - NN cord-289926-y1rjgbui 134 4 value value NN cord-289926-y1rjgbui 134 5 indicates indicate VBZ cord-289926-y1rjgbui 134 6 that that IN cord-289926-y1rjgbui 134 7 the the DT cord-289926-y1rjgbui 134 8 database database NN cord-289926-y1rjgbui 134 9 search search NN cord-289926-y1rjgbui 134 10 with with IN cord-289926-y1rjgbui 134 11 the the DT cord-289926-y1rjgbui 134 12 RNA RNA NNP cord-289926-y1rjgbui 134 13 - - HYPH cord-289926-y1rjgbui 134 14 binding bind VBG cord-289926-y1rjgbui 134 15 domain domain NN cord-289926-y1rjgbui 134 16 of of IN cord-289926-y1rjgbui 134 17 HDAg HDAg NNS cord-289926-y1rjgbui 134 18 will will MD cord-289926-y1rjgbui 134 19 identify identify VB cord-289926-y1rjgbui 134 20 approximately approximately RB cord-289926-y1rjgbui 134 21 25 25 CD cord-289926-y1rjgbui 134 22 unrelated unrelated JJ cord-289926-y1rjgbui 134 23 proteins protein NNS cord-289926-y1rjgbui 134 24 that that WDT cord-289926-y1rjgbui 134 25 will will MD cord-289926-y1rjgbui 134 26 have have VB cord-289926-y1rjgbui 134 27 alignment alignment NN cord-289926-y1rjgbui 134 28 scores score NNS cord-289926-y1rjgbui 134 29 as as IN cord-289926-y1rjgbui 134 30 good good JJ cord-289926-y1rjgbui 134 31 or or CC cord-289926-y1rjgbui 134 32 better well JJR cord-289926-y1rjgbui 134 33 than than IN cord-289926-y1rjgbui 134 34 DIPA DIPA NNP cord-289926-y1rjgbui 134 35 alignment alignment NN cord-289926-y1rjgbui 134 36 . . . cord-289926-y1rjgbui 135 1 In in IN cord-289926-y1rjgbui 135 2 fact fact NN cord-289926-y1rjgbui 135 3 , , , cord-289926-y1rjgbui 135 4 the the DT cord-289926-y1rjgbui 135 5 alignment alignment NN cord-289926-y1rjgbui 135 6 of of IN cord-289926-y1rjgbui 135 7 DIPA DIPA NNP cord-289926-y1rjgbui 135 8 and and CC cord-289926-y1rjgbui 135 9 the the DT cord-289926-y1rjgbui 135 10 HIV HIV NNP cord-289926-y1rjgbui 135 11 rev rev NNP cord-289926-y1rjgbui 135 12 protein protein NN cord-289926-y1rjgbui 135 13 ( ( -LRB- cord-289926-y1rjgbui 135 14 Fig Fig NNP cord-289926-y1rjgbui 135 15 . . . cord-289926-y1rjgbui 135 16 2E 2E NNP cord-289926-y1rjgbui 135 17 ) ) -RRB- cord-289926-y1rjgbui 135 18 , , , cord-289926-y1rjgbui 135 19 which which WDT cord-289926-y1rjgbui 135 20 is be VBZ cord-289926-y1rjgbui 135 21 presumably presumably RB cord-289926-y1rjgbui 135 22 unrelated unrelated JJ cord-289926-y1rjgbui 135 23 to to IN cord-289926-y1rjgbui 135 24 DIPA DIPA NNP cord-289926-y1rjgbui 135 25 , , , cord-289926-y1rjgbui 135 26 has have VBZ cord-289926-y1rjgbui 135 27 a a DT cord-289926-y1rjgbui 135 28 similar similar JJ cord-289926-y1rjgbui 135 29 Z z NN cord-289926-y1rjgbui 135 30 score score NN cord-289926-y1rjgbui 135 31 = = SYM cord-289926-y1rjgbui 135 32 4.7 4.7 CD cord-289926-y1rjgbui 135 33 . . . cord-289926-y1rjgbui 136 1 Alignments alignment NNS cord-289926-y1rjgbui 136 2 of of IN cord-289926-y1rjgbui 136 3 other other JJ cord-289926-y1rjgbui 136 4 DIPA DIPA NNP cord-289926-y1rjgbui 136 5 regions region NNS cord-289926-y1rjgbui 136 6 or or CC cord-289926-y1rjgbui 136 7 of of IN cord-289926-y1rjgbui 136 8 the the DT cord-289926-y1rjgbui 136 9 entire entire JJ cord-289926-y1rjgbui 136 10 DIPA DIPA NNP cord-289926-y1rjgbui 136 11 protein protein NN cord-289926-y1rjgbui 136 12 with with IN cord-289926-y1rjgbui 136 13 SRY SRY NNP cord-289926-y1rjgbui 136 14 produced produce VBD cord-289926-y1rjgbui 136 15 even even RB cord-289926-y1rjgbui 136 16 less less RBR cord-289926-y1rjgbui 136 17 significant significant JJ cord-289926-y1rjgbui 136 18 Z z NN cord-289926-y1rjgbui 136 19 scores score NNS cord-289926-y1rjgbui 136 20 ( ( -LRB- cord-289926-y1rjgbui 136 21 Fig Fig NNP cord-289926-y1rjgbui 136 22 . . . cord-289926-y1rjgbui 136 23 2D 2D NNP cord-289926-y1rjgbui 136 24 ) ) -RRB- cord-289926-y1rjgbui 136 25 . . . cord-289926-y1rjgbui 137 1 Statistical statistical JJ cord-289926-y1rjgbui 137 2 analysis analysis NN cord-289926-y1rjgbui 137 3 recently recently RB cord-289926-y1rjgbui 137 4 performed perform VBN cord-289926-y1rjgbui 137 5 by by IN cord-289926-y1rjgbui 137 6 Long Long NNP cord-289926-y1rjgbui 137 7 et et NNP cord-289926-y1rjgbui 137 8 al al NNP cord-289926-y1rjgbui 137 9 . . . cord-289926-y1rjgbui 138 1 considered consider VBN cord-289926-y1rjgbui 138 2 the the DT cord-289926-y1rjgbui 138 3 entire entire JJ cord-289926-y1rjgbui 138 4 DIPA DIPA NNP cord-289926-y1rjgbui 138 5 sequence sequence NN cord-289926-y1rjgbui 138 6 ; ; : cord-289926-y1rjgbui 138 7 it -PRON- PRP cord-289926-y1rjgbui 138 8 also also RB cord-289926-y1rjgbui 138 9 indicated indicate VBD cord-289926-y1rjgbui 138 10 that that DT cord-289926-y1rjgbui 138 11 sequence sequence NN cord-289926-y1rjgbui 138 12 similarity similarity NN cord-289926-y1rjgbui 138 13 between between IN cord-289926-y1rjgbui 138 14 HDAg HDAg NNS cord-289926-y1rjgbui 138 15 and and CC cord-289926-y1rjgbui 138 16 DIPA DIPA NNP cord-289926-y1rjgbui 138 17 is be VBZ cord-289926-y1rjgbui 138 18 not not RB cord-289926-y1rjgbui 138 19 significant significant JJ cord-289926-y1rjgbui 138 20 [ [ -LRB- cord-289926-y1rjgbui 138 21 34 34 CD cord-289926-y1rjgbui 138 22 ] ] -RRB- cord-289926-y1rjgbui 138 23 . . . cord-289926-y1rjgbui 139 1 The the DT cord-289926-y1rjgbui 139 2 P p NN cord-289926-y1rjgbui 139 3 - - HYPH cord-289926-y1rjgbui 139 4 value value NN cord-289926-y1rjgbui 139 5 of of IN cord-289926-y1rjgbui 139 6 the the DT cord-289926-y1rjgbui 139 7 alignment alignment NN cord-289926-y1rjgbui 139 8 of of IN cord-289926-y1rjgbui 139 9 the the DT cord-289926-y1rjgbui 139 10 entire entire JJ cord-289926-y1rjgbui 139 11 DIPA DIPA NNP cord-289926-y1rjgbui 139 12 and and CC cord-289926-y1rjgbui 139 13 HDAg hdag NN cord-289926-y1rjgbui 139 14 proteins protein NNS cord-289926-y1rjgbui 139 15 is be VBZ cord-289926-y1rjgbui 139 16 2 2 CD cord-289926-y1rjgbui 139 17 × × NN cord-289926-y1rjgbui 139 18 10 10 CD cord-289926-y1rjgbui 139 19 −3 −3 NN cord-289926-y1rjgbui 139 20 as as IN cord-289926-y1rjgbui 139 21 reported report VBN cord-289926-y1rjgbui 139 22 by by IN cord-289926-y1rjgbui 139 23 Brazas Brazas NNP cord-289926-y1rjgbui 139 24 and and CC cord-289926-y1rjgbui 139 25 Ganem Ganem NNP cord-289926-y1rjgbui 139 26 in in IN cord-289926-y1rjgbui 139 27 their -PRON- PRP$ cord-289926-y1rjgbui 139 28 reply reply NN cord-289926-y1rjgbui 139 29 to to IN cord-289926-y1rjgbui 139 30 Long Long NNP cord-289926-y1rjgbui 139 31 et et NNP cord-289926-y1rjgbui 139 32 al al NNP cord-289926-y1rjgbui 139 33 . . . cord-289926-y1rjgbui 140 1 [ [ -LRB- cord-289926-y1rjgbui 140 2 4 4 CD cord-289926-y1rjgbui 140 3 ] ] -RRB- cord-289926-y1rjgbui 140 4 . . . cord-289926-y1rjgbui 141 1 This this DT cord-289926-y1rjgbui 141 2 value value NN cord-289926-y1rjgbui 141 3 is be VBZ cord-289926-y1rjgbui 141 4 less less RBR cord-289926-y1rjgbui 141 5 significant significant JJ cord-289926-y1rjgbui 141 6 than than IN cord-289926-y1rjgbui 141 7 the the DT cord-289926-y1rjgbui 141 8 Pvalue Pvalue NNP cord-289926-y1rjgbui 141 9 for for IN cord-289926-y1rjgbui 141 10 the the DT cord-289926-y1rjgbui 141 11 DIPA DIPA NNP cord-289926-y1rjgbui 141 12 fragment fragment NN cord-289926-y1rjgbui 141 13 reported report VBD cord-289926-y1rjgbui 141 14 above above RB cord-289926-y1rjgbui 141 15 . . . cord-289926-y1rjgbui 142 1 The the DT cord-289926-y1rjgbui 142 2 presence presence NN cord-289926-y1rjgbui 142 3 of of IN cord-289926-y1rjgbui 142 4 the the DT cord-289926-y1rjgbui 142 5 bZIP bzip CD cord-289926-y1rjgbui 142 6 domains domain NNS cord-289926-y1rjgbui 142 7 , , , cord-289926-y1rjgbui 142 8 which which WDT cord-289926-y1rjgbui 142 9 made make VBD cord-289926-y1rjgbui 142 10 detection detection NN cord-289926-y1rjgbui 142 11 of of IN cord-289926-y1rjgbui 142 12 functional functional JJ cord-289926-y1rjgbui 142 13 interaction interaction NN cord-289926-y1rjgbui 142 14 between between IN cord-289926-y1rjgbui 142 15 DIPA DIPA NNP cord-289926-y1rjgbui 142 16 and and CC cord-289926-y1rjgbui 142 17 HDAg hdag NN cord-289926-y1rjgbui 142 18 possible possible JJ cord-289926-y1rjgbui 142 19 [ [ -LRB- cord-289926-y1rjgbui 142 20 5 5 CD cord-289926-y1rjgbui 142 21 ] ] -RRB- cord-289926-y1rjgbui 142 22 , , , cord-289926-y1rjgbui 142 23 should should MD cord-289926-y1rjgbui 142 24 also also RB cord-289926-y1rjgbui 142 25 serve serve VB cord-289926-y1rjgbui 142 26 as as IN cord-289926-y1rjgbui 142 27 a a DT cord-289926-y1rjgbui 142 28 warning warning NN cord-289926-y1rjgbui 142 29 during during IN cord-289926-y1rjgbui 142 30 sequence sequence NN cord-289926-y1rjgbui 142 31 analysis analysis NN cord-289926-y1rjgbui 142 32 : : : cord-289926-y1rjgbui 142 33 bZIP bzip CD cord-289926-y1rjgbui 142 34 domains domain NNS cord-289926-y1rjgbui 142 35 are be VBP cord-289926-y1rjgbui 142 36 compositionally compositionally RB cord-289926-y1rjgbui 142 37 biased biased JJ cord-289926-y1rjgbui 142 38 and and CC cord-289926-y1rjgbui 142 39 this this DT cord-289926-y1rjgbui 142 40 bias bias NN cord-289926-y1rjgbui 142 41 makes make VBZ cord-289926-y1rjgbui 142 42 it -PRON- PRP cord-289926-y1rjgbui 142 43 more more RBR cord-289926-y1rjgbui 142 44 likely likely JJ cord-289926-y1rjgbui 142 45 to to TO cord-289926-y1rjgbui 142 46 obtain obtain VB cord-289926-y1rjgbui 142 47 high high JJ cord-289926-y1rjgbui 142 48 alignment alignment NN cord-289926-y1rjgbui 142 49 scores score NNS cord-289926-y1rjgbui 142 50 with with IN cord-289926-y1rjgbui 142 51 unrelated unrelated JJ cord-289926-y1rjgbui 142 52 proteins protein NNS cord-289926-y1rjgbui 142 53 . . . cord-289926-y1rjgbui 143 1 The the DT cord-289926-y1rjgbui 143 2 Monte Monte NNP cord-289926-y1rjgbui 143 3 Carlo Carlo NNP cord-289926-y1rjgbui 143 4 analysis analysis NN cord-289926-y1rjgbui 143 5 of of IN cord-289926-y1rjgbui 143 6 the the DT cord-289926-y1rjgbui 143 7 partial partial JJ cord-289926-y1rjgbui 143 8 alignment alignment NN cord-289926-y1rjgbui 143 9 of of IN cord-289926-y1rjgbui 143 10 the the DT cord-289926-y1rjgbui 143 11 HMG HMG NNP cord-289926-y1rjgbui 143 12 domain domain NN cord-289926-y1rjgbui 143 13 of of IN cord-289926-y1rjgbui 143 14 SRY SRY NNP cord-289926-y1rjgbui 143 15 and and CC cord-289926-y1rjgbui 143 16 the the DT cord-289926-y1rjgbui 143 17 RNA RNA NNP cord-289926-y1rjgbui 143 18 - - HYPH cord-289926-y1rjgbui 143 19 binding bind VBG cord-289926-y1rjgbui 143 20 domain domain NN cord-289926-y1rjgbui 143 21 of of IN cord-289926-y1rjgbui 143 22 HDAg hdag NN cord-289926-y1rjgbui 143 23 produces produce VBZ cord-289926-y1rjgbui 143 24 a a DT cord-289926-y1rjgbui 143 25 Z z NN cord-289926-y1rjgbui 143 26 score score NN cord-289926-y1rjgbui 143 27 of of IN cord-289926-y1rjgbui 143 28 6.85 6.85 CD cord-289926-y1rjgbui 143 29 -a -a : cord-289926-y1rjgbui 143 30 statistically statistically RB cord-289926-y1rjgbui 143 31 significant significant JJ cord-289926-y1rjgbui 143 32 value value NN cord-289926-y1rjgbui 143 33 ( ( -LRB- cord-289926-y1rjgbui 143 34 Fig Fig NNP cord-289926-y1rjgbui 143 35 . . . cord-289926-y1rjgbui 143 36 2A 2a CD cord-289926-y1rjgbui 143 37 ) ) -RRB- cord-289926-y1rjgbui 143 38 . . . cord-289926-y1rjgbui 144 1 The the DT cord-289926-y1rjgbui 144 2 P p NN cord-289926-y1rjgbui 144 3 - - HYPH cord-289926-y1rjgbui 144 4 value value NN cord-289926-y1rjgbui 144 5 for for IN cord-289926-y1rjgbui 144 6 this this DT cord-289926-y1rjgbui 144 7 alignment alignment NN cord-289926-y1rjgbui 144 8 is be VBZ cord-289926-y1rjgbui 144 9 7.6 7.6 CD cord-289926-y1rjgbui 144 10 × × NN cord-289926-y1rjgbui 144 11 10 10 CD cord-289926-y1rjgbui 144 12 −7 −7 NNP cord-289926-y1rjgbui 144 13 , , , cord-289926-y1rjgbui 144 14 indicating indicate VBG cord-289926-y1rjgbui 144 15 that that IN cord-289926-y1rjgbui 144 16 an an DT cord-289926-y1rjgbui 144 17 alignment alignment NN cord-289926-y1rjgbui 144 18 this this DT cord-289926-y1rjgbui 144 19 good good NN cord-289926-y1rjgbui 144 20 is be VBZ cord-289926-y1rjgbui 144 21 unlikely unlikely JJ cord-289926-y1rjgbui 144 22 to to TO cord-289926-y1rjgbui 144 23 arise arise VB cord-289926-y1rjgbui 144 24 by by IN cord-289926-y1rjgbui 144 25 chance chance NN cord-289926-y1rjgbui 144 26 , , , cord-289926-y1rjgbui 144 27 even even RB cord-289926-y1rjgbui 144 28 when when WRB cord-289926-y1rjgbui 144 29 analysis analysis NN cord-289926-y1rjgbui 144 30 is be VBZ cord-289926-y1rjgbui 144 31 limited limit VBN cord-289926-y1rjgbui 144 32 to to IN cord-289926-y1rjgbui 144 33 the the DT cord-289926-y1rjgbui 144 34 compositionally compositionally RB cord-289926-y1rjgbui 144 35 biased biased JJ cord-289926-y1rjgbui 144 36 HMG HMG NNP cord-289926-y1rjgbui 144 37 box box NN cord-289926-y1rjgbui 144 38 region region NN cord-289926-y1rjgbui 144 39 . . . cord-289926-y1rjgbui 145 1 E e NN cord-289926-y1rjgbui 145 2 - - NN cord-289926-y1rjgbui 145 3 value value NN cord-289926-y1rjgbui 145 4 of of IN cord-289926-y1rjgbui 145 5 this this DT cord-289926-y1rjgbui 145 6 alignment alignment NN cord-289926-y1rjgbui 145 7 is be VBZ cord-289926-y1rjgbui 145 8 0.05 0.05 CD cord-289926-y1rjgbui 145 9 for for IN cord-289926-y1rjgbui 145 10 the the DT cord-289926-y1rjgbui 145 11 latest late JJS cord-289926-y1rjgbui 145 12 release release NN cord-289926-y1rjgbui 145 13 of of IN cord-289926-y1rjgbui 145 14 SWISS SWISS NNP cord-289926-y1rjgbui 145 15 - - HYPH cord-289926-y1rjgbui 145 16 PROT PROT NNP cord-289926-y1rjgbui 145 17 ( ( -LRB- cord-289926-y1rjgbui 145 18 release35 release35 NNP cord-289926-y1rjgbui 145 19 ) ) -RRB- cord-289926-y1rjgbui 145 20 ; ; : cord-289926-y1rjgbui 145 21 thus thus RB cord-289926-y1rjgbui 145 22 an an DT cord-289926-y1rjgbui 145 23 unrelated unrelated JJ cord-289926-y1rjgbui 145 24 protein protein NN cord-289926-y1rjgbui 145 25 with with IN cord-289926-y1rjgbui 145 26 an an DT cord-289926-y1rjgbui 145 27 alignment alignment NN cord-289926-y1rjgbui 145 28 score score NN cord-289926-y1rjgbui 145 29 as as RB cord-289926-y1rjgbui 145 30 good good JJ cord-289926-y1rjgbui 145 31 or or CC cord-289926-y1rjgbui 145 32 better well JJR cord-289926-y1rjgbui 145 33 as as IN cord-289926-y1rjgbui 145 34 that that DT cord-289926-y1rjgbui 145 35 of of IN cord-289926-y1rjgbui 145 36 the the DT cord-289926-y1rjgbui 145 37 HMG HMG NNP cord-289926-y1rjgbui 145 38 domain domain NN cord-289926-y1rjgbui 145 39 of of IN cord-289926-y1rjgbui 145 40 SRY SRY NNP cord-289926-y1rjgbui 145 41 and and CC cord-289926-y1rjgbui 145 42 the the DT cord-289926-y1rjgbui 145 43 RNA RNA NNP cord-289926-y1rjgbui 145 44 - - HYPH cord-289926-y1rjgbui 145 45 binding bind VBG cord-289926-y1rjgbui 145 46 domain domain NN cord-289926-y1rjgbui 145 47 of of IN cord-289926-y1rjgbui 145 48 HDAg HDAg NNS cord-289926-y1rjgbui 145 49 will will MD cord-289926-y1rjgbui 145 50 be be VB cord-289926-y1rjgbui 145 51 expected expect VBN cord-289926-y1rjgbui 145 52 to to TO cord-289926-y1rjgbui 145 53 be be VB cord-289926-y1rjgbui 145 54 found find VBN cord-289926-y1rjgbui 145 55 only only RB cord-289926-y1rjgbui 145 56 after after IN cord-289926-y1rjgbui 145 57 20-fold 20-fold CD cord-289926-y1rjgbui 145 58 increase increase NN cord-289926-y1rjgbui 145 59 in in IN cord-289926-y1rjgbui 145 60 the the DT cord-289926-y1rjgbui 145 61 size size NN cord-289926-y1rjgbui 145 62 of of IN cord-289926-y1rjgbui 145 63 the the DT cord-289926-y1rjgbui 145 64 current current JJ cord-289926-y1rjgbui 145 65 database database NN cord-289926-y1rjgbui 145 66 . . . cord-289926-y1rjgbui 146 1 A a DT cord-289926-y1rjgbui 146 2 cellular cellular JJ cord-289926-y1rjgbui 146 3 gene gene NN cord-289926-y1rjgbui 146 4 and and CC cord-289926-y1rjgbui 146 5 its -PRON- PRP$ cord-289926-y1rjgbui 146 6 RNA RNA NNP cord-289926-y1rjgbui 146 7 viral viral JJ cord-289926-y1rjgbui 146 8 cognate cognate NN cord-289926-y1rjgbui 146 9 diverge diverge VBP cord-289926-y1rjgbui 146 10 more more RBR cord-289926-y1rjgbui 146 11 rapidly rapidly RB cord-289926-y1rjgbui 146 12 than than IN cord-289926-y1rjgbui 146 13 would would MD cord-289926-y1rjgbui 146 14 be be VB cord-289926-y1rjgbui 146 15 expected expect VBN cord-289926-y1rjgbui 146 16 for for IN cord-289926-y1rjgbui 146 17 two two CD cord-289926-y1rjgbui 146 18 cellular cellular JJ cord-289926-y1rjgbui 146 19 genes gene NNS cord-289926-y1rjgbui 146 20 due due JJ cord-289926-y1rjgbui 146 21 to to IN cord-289926-y1rjgbui 146 22 the the DT cord-289926-y1rjgbui 146 23 low low JJ cord-289926-y1rjgbui 146 24 fidelity fidelity NN cord-289926-y1rjgbui 146 25 of of IN cord-289926-y1rjgbui 146 26 RNA RNA NNP cord-289926-y1rjgbui 146 27 replication replication NN cord-289926-y1rjgbui 146 28 . . . cord-289926-y1rjgbui 147 1 Because because IN cord-289926-y1rjgbui 147 2 of of IN cord-289926-y1rjgbui 147 3 this this DT cord-289926-y1rjgbui 147 4 rapid rapid JJ cord-289926-y1rjgbui 147 5 divergence divergence NN cord-289926-y1rjgbui 147 6 , , , cord-289926-y1rjgbui 147 7 one one PRP cord-289926-y1rjgbui 147 8 would would MD cord-289926-y1rjgbui 147 9 expect expect VB cord-289926-y1rjgbui 147 10 the the DT cord-289926-y1rjgbui 147 11 similarity similarity NN cord-289926-y1rjgbui 147 12 between between IN cord-289926-y1rjgbui 147 13 a a DT cord-289926-y1rjgbui 147 14 DNAencoded dnaencoded JJ cord-289926-y1rjgbui 147 15 gene gene NN cord-289926-y1rjgbui 147 16 and and CC cord-289926-y1rjgbui 147 17 its -PRON- PRP$ cord-289926-y1rjgbui 147 18 RNA RNA NNP cord-289926-y1rjgbui 147 19 - - HYPH cord-289926-y1rjgbui 147 20 encoded encode VBN cord-289926-y1rjgbui 147 21 counterpart counterpart NN cord-289926-y1rjgbui 147 22 to to TO cord-289926-y1rjgbui 147 23 correspond correspond VB cord-289926-y1rjgbui 147 24 to to IN cord-289926-y1rjgbui 147 25 the the DT cord-289926-y1rjgbui 147 26 regions region NNS cord-289926-y1rjgbui 147 27 that that WDT cord-289926-y1rjgbui 147 28 are be VBP cord-289926-y1rjgbui 147 29 absolutely absolutely RB cord-289926-y1rjgbui 147 30 essential essential JJ cord-289926-y1rjgbui 147 31 for for IN cord-289926-y1rjgbui 147 32 the the DT cord-289926-y1rjgbui 147 33 function function NN cord-289926-y1rjgbui 147 34 of of IN cord-289926-y1rjgbui 147 35 the the DT cord-289926-y1rjgbui 147 36 protein protein NN cord-289926-y1rjgbui 147 37 . . . cord-289926-y1rjgbui 148 1 In in IN cord-289926-y1rjgbui 148 2 the the DT cord-289926-y1rjgbui 148 3 case case NN cord-289926-y1rjgbui 148 4 of of IN cord-289926-y1rjgbui 148 5 SRY SRY NNP cord-289926-y1rjgbui 148 6 - - HYPH cord-289926-y1rjgbui 148 7 HDAg HDAg NNP cord-289926-y1rjgbui 148 8 this this DT cord-289926-y1rjgbui 148 9 is be VBZ cord-289926-y1rjgbui 148 10 indeed indeed RB cord-289926-y1rjgbui 148 11 the the DT cord-289926-y1rjgbui 148 12 case case NN cord-289926-y1rjgbui 148 13 : : : cord-289926-y1rjgbui 148 14 the the DT cord-289926-y1rjgbui 148 15 region region NN cord-289926-y1rjgbui 148 16 of of IN cord-289926-y1rjgbui 148 17 similarity similarity NN cord-289926-y1rjgbui 148 18 is be VBZ cord-289926-y1rjgbui 148 19 limited limit VBN cord-289926-y1rjgbui 148 20 to to IN cord-289926-y1rjgbui 148 21 the the DT cord-289926-y1rjgbui 148 22 RNA RNA NNP cord-289926-y1rjgbui 148 23 - - HYPH cord-289926-y1rjgbui 148 24 binding bind VBG cord-289926-y1rjgbui 148 25 region region NN cord-289926-y1rjgbui 148 26 of of IN cord-289926-y1rjgbui 148 27 HDAg HDAg NNS cord-289926-y1rjgbui 148 28 , , , cord-289926-y1rjgbui 148 29 which which WDT cord-289926-y1rjgbui 148 30 as as IN cord-289926-y1rjgbui 148 31 been be VBN cord-289926-y1rjgbui 148 32 shown show VBN cord-289926-y1rjgbui 148 33 to to TO cord-289926-y1rjgbui 148 34 be be VB cord-289926-y1rjgbui 148 35 functionally functionally RB cord-289926-y1rjgbui 148 36 important important JJ cord-289926-y1rjgbui 148 37 [ [ -LRB- cord-289926-y1rjgbui 148 38 32 32 CD cord-289926-y1rjgbui 148 39 ] ] -RRB- cord-289926-y1rjgbui 148 40 . . . cord-289926-y1rjgbui 149 1 Two two CD cord-289926-y1rjgbui 149 2 nuclear nuclear JJ cord-289926-y1rjgbui 149 3 localization localization NN cord-289926-y1rjgbui 149 4 signals signal NNS cord-289926-y1rjgbui 149 5 ( ( -LRB- cord-289926-y1rjgbui 149 6 NLSs nls NNS cord-289926-y1rjgbui 149 7 ) ) -RRB- cord-289926-y1rjgbui 149 8 recently recently RB cord-289926-y1rjgbui 149 9 identified identify VBN cord-289926-y1rjgbui 149 10 within within IN cord-289926-y1rjgbui 149 11 the the DT cord-289926-y1rjgbui 149 12 HMG HMG NNP cord-289926-y1rjgbui 149 13 domain domain NN cord-289926-y1rjgbui 149 14 of of IN cord-289926-y1rjgbui 149 15 SRY SRY NNP cord-289926-y1rjgbui 149 16 are be VBP cord-289926-y1rjgbui 149 17 also also RB cord-289926-y1rjgbui 149 18 conserved conserve VBN cord-289926-y1rjgbui 149 19 within within IN cord-289926-y1rjgbui 149 20 the the DT cord-289926-y1rjgbui 149 21 RNA RNA NNP cord-289926-y1rjgbui 149 22 - - HYPH cord-289926-y1rjgbui 149 23 binding bind VBG cord-289926-y1rjgbui 149 24 domain domain NN cord-289926-y1rjgbui 149 25 of of IN cord-289926-y1rjgbui 149 26 HDAg HDAg NNS cord-289926-y1rjgbui 149 27 [ [ -LRB- cord-289926-y1rjgbui 149 28 43 43 CD cord-289926-y1rjgbui 149 29 ] ] -RRB- cord-289926-y1rjgbui 149 30 . . . cord-289926-y1rjgbui 150 1 These these DT cord-289926-y1rjgbui 150 2 NLSs nls NNS cord-289926-y1rjgbui 150 3 are be VBP cord-289926-y1rjgbui 150 4 distinct distinct JJ cord-289926-y1rjgbui 150 5 from from IN cord-289926-y1rjgbui 150 6 an an DT cord-289926-y1rjgbui 150 7 already already RB cord-289926-y1rjgbui 150 8 identified identify VBN cord-289926-y1rjgbui 150 9 bipartite bipartite JJ cord-289926-y1rjgbui 150 10 NLS nls NN cord-289926-y1rjgbui 150 11 within within IN cord-289926-y1rjgbui 150 12 HDAg HDAg NNS cord-289926-y1rjgbui 150 13 which which WDT cord-289926-y1rjgbui 150 14 is be VBZ cord-289926-y1rjgbui 150 15 located locate VBN cord-289926-y1rjgbui 150 16 to to IN cord-289926-y1rjgbui 150 17 the the DT cord-289926-y1rjgbui 150 18 amino amino NN cord-289926-y1rjgbui 150 19 terminal terminal JJ cord-289926-y1rjgbui 150 20 side side NN cord-289926-y1rjgbui 150 21 of of IN cord-289926-y1rjgbui 150 22 the the DT cord-289926-y1rjgbui 150 23 RNA RNA NNP cord-289926-y1rjgbui 150 24 - - HYPH cord-289926-y1rjgbui 150 25 binding bind VBG cord-289926-y1rjgbui 150 26 domain domain NN cord-289926-y1rjgbui 150 27 [ [ -LRB- cord-289926-y1rjgbui 150 28 49 49 CD cord-289926-y1rjgbui 150 29 ] ] -RRB- cord-289926-y1rjgbui 150 30 . . . cord-289926-y1rjgbui 151 1 Our -PRON- PRP$ cord-289926-y1rjgbui 151 2 model model NN cord-289926-y1rjgbui 151 3 predicts predict VBZ cord-289926-y1rjgbui 151 4 these these DT cord-289926-y1rjgbui 151 5 new new JJ cord-289926-y1rjgbui 151 6 NLSs nls NNS cord-289926-y1rjgbui 151 7 should should MD cord-289926-y1rjgbui 151 8 be be VB cord-289926-y1rjgbui 151 9 functional functional JJ cord-289926-y1rjgbui 151 10 in in IN cord-289926-y1rjgbui 151 11 HDAg hdag NN cord-289926-y1rjgbui 151 12 . . . cord-289926-y1rjgbui 152 1 Recent recent JJ cord-289926-y1rjgbui 152 2 experiments experiment NNS cord-289926-y1rjgbui 152 3 demonstrate demonstrate VBP cord-289926-y1rjgbui 152 4 that that IN cord-289926-y1rjgbui 152 5 the the DT cord-289926-y1rjgbui 152 6 presence presence NN cord-289926-y1rjgbui 152 7 of of IN cord-289926-y1rjgbui 152 8 either either DT cord-289926-y1rjgbui 152 9 one one CD cord-289926-y1rjgbui 152 10 of of IN cord-289926-y1rjgbui 152 11 the the DT cord-289926-y1rjgbui 152 12 ARM arm NN cord-289926-y1rjgbui 152 13 sequences sequence NNS cord-289926-y1rjgbui 152 14 is be VBZ cord-289926-y1rjgbui 152 15 sufficient sufficient JJ cord-289926-y1rjgbui 152 16 for for IN cord-289926-y1rjgbui 152 17 nuclear nuclear JJ cord-289926-y1rjgbui 152 18 localization localization NN cord-289926-y1rjgbui 152 19 of of IN cord-289926-y1rjgbui 152 20 the the DT cord-289926-y1rjgbui 152 21 antigen antigen NN cord-289926-y1rjgbui 152 22 , , , cord-289926-y1rjgbui 152 23 supporting support VBG cord-289926-y1rjgbui 152 24 our -PRON- PRP$ cord-289926-y1rjgbui 152 25 prediction prediction NN cord-289926-y1rjgbui 152 26 [ [ -LRB- cord-289926-y1rjgbui 152 27 9 9 CD cord-289926-y1rjgbui 152 28 ] ] -RRB- cord-289926-y1rjgbui 152 29 . . . cord-289926-y1rjgbui 153 1 SRY SRY NNP cord-289926-y1rjgbui 153 2 is be VBZ cord-289926-y1rjgbui 153 3 the the DT cord-289926-y1rjgbui 153 4 only only JJ cord-289926-y1rjgbui 153 5 gene gene NN cord-289926-y1rjgbui 153 6 from from IN cord-289926-y1rjgbui 153 7 the the DT cord-289926-y1rjgbui 153 8 Y Y NNP cord-289926-y1rjgbui 153 9 chromosome chromosome NN cord-289926-y1rjgbui 153 10 known know VBN cord-289926-y1rjgbui 153 11 to to TO cord-289926-y1rjgbui 153 12 be be VB cord-289926-y1rjgbui 153 13 involved involve VBN cord-289926-y1rjgbui 153 14 in in IN cord-289926-y1rjgbui 153 15 testis testis NN cord-289926-y1rjgbui 153 16 development development NN cord-289926-y1rjgbui 153 17 . . . cord-289926-y1rjgbui 154 1 It -PRON- PRP cord-289926-y1rjgbui 154 2 is be VBZ cord-289926-y1rjgbui 154 3 most most RBS cord-289926-y1rjgbui 154 4 closely closely RB cord-289926-y1rjgbui 154 5 related related JJ cord-289926-y1rjgbui 154 6 to to IN cord-289926-y1rjgbui 154 7 the the DT cord-289926-y1rjgbui 154 8 SOX3 SOX3 NNP cord-289926-y1rjgbui 154 9 gene gene NN cord-289926-y1rjgbui 154 10 : : : cord-289926-y1rjgbui 154 11 these these DT cord-289926-y1rjgbui 154 12 genes gene NNS cord-289926-y1rjgbui 154 13 were be VBD cord-289926-y1rjgbui 154 14 proposed propose VBN cord-289926-y1rjgbui 154 15 at at IN cord-289926-y1rjgbui 154 16 one one CD cord-289926-y1rjgbui 154 17 time time NN cord-289926-y1rjgbui 154 18 to to TO cord-289926-y1rjgbui 154 19 be be VB cord-289926-y1rjgbui 154 20 alleles allele NNS cord-289926-y1rjgbui 154 21 of of IN cord-289926-y1rjgbui 154 22 a a DT cord-289926-y1rjgbui 154 23 developmental developmental JJ cord-289926-y1rjgbui 154 24 gene gene NN cord-289926-y1rjgbui 154 25 on on IN cord-289926-y1rjgbui 154 26 the the DT cord-289926-y1rjgbui 154 27 undifferentiated undifferentiated JJ cord-289926-y1rjgbui 154 28 or or CC cord-289926-y1rjgbui 154 29 partially partially RB cord-289926-y1rjgbui 154 30 differentiated differentiate VBN cord-289926-y1rjgbui 154 31 proto proto JJ cord-289926-y1rjgbui 154 32 - - HYPH cord-289926-y1rjgbui 154 33 X x NN cord-289926-y1rjgbui 154 34 and and CC cord-289926-y1rjgbui 154 35 proto proto NN cord-289926-y1rjgbui 154 36 - - HYPH cord-289926-y1rjgbui 154 37 Y y NN cord-289926-y1rjgbui 154 38 [ [ -LRB- cord-289926-y1rjgbui 154 39 21 21 CD cord-289926-y1rjgbui 154 40 ] ] -RRB- cord-289926-y1rjgbui 154 41 . . . cord-289926-y1rjgbui 155 1 SRY SRY NNP cord-289926-y1rjgbui 155 2 is be VBZ cord-289926-y1rjgbui 155 3 a a DT cord-289926-y1rjgbui 155 4 member member NN cord-289926-y1rjgbui 155 5 of of IN cord-289926-y1rjgbui 155 6 HMG HMG NNP cord-289926-y1rjgbui 155 7 superfamily superfamily NN cord-289926-y1rjgbui 155 8 ; ; : cord-289926-y1rjgbui 155 9 it -PRON- PRP cord-289926-y1rjgbui 155 10 possesses possess VBZ cord-289926-y1rjgbui 155 11 a a DT cord-289926-y1rjgbui 155 12 79-residue 79-residue JJ cord-289926-y1rjgbui 155 13 long long JJ cord-289926-y1rjgbui 155 14 HMG HMG NNP cord-289926-y1rjgbui 155 15 box box NN cord-289926-y1rjgbui 155 16 which which WDT cord-289926-y1rjgbui 155 17 binds bind VBZ cord-289926-y1rjgbui 155 18 to to IN cord-289926-y1rjgbui 155 19 a a DT cord-289926-y1rjgbui 155 20 well well RB cord-289926-y1rjgbui 155 21 - - HYPH cord-289926-y1rjgbui 155 22 defined define VBN cord-289926-y1rjgbui 155 23 consensus consensus NN cord-289926-y1rjgbui 155 24 sequence sequence NN cord-289926-y1rjgbui 155 25 : : : cord-289926-y1rjgbui 155 26 5 5 CD cord-289926-y1rjgbui 155 27 -CCTTTGA -CCTTTGA : cord-289926-y1rjgbui 155 28 and and CC cord-289926-y1rjgbui 155 29 probably probably RB cord-289926-y1rjgbui 155 30 controls control VBZ cord-289926-y1rjgbui 155 31 the the DT cord-289926-y1rjgbui 155 32 transcription transcription NN cord-289926-y1rjgbui 155 33 of of IN cord-289926-y1rjgbui 155 34 other other JJ cord-289926-y1rjgbui 155 35 sex sex NN cord-289926-y1rjgbui 155 36 - - HYPH cord-289926-y1rjgbui 155 37 determination determination NN cord-289926-y1rjgbui 155 38 genes gene NNS cord-289926-y1rjgbui 155 39 . . . cord-289926-y1rjgbui 156 1 The the DT cord-289926-y1rjgbui 156 2 HMG HMG NNP cord-289926-y1rjgbui 156 3 superfamily superfamily NN cord-289926-y1rjgbui 156 4 is be VBZ cord-289926-y1rjgbui 156 5 ancient ancient JJ cord-289926-y1rjgbui 156 6 -it -it . cord-289926-y1rjgbui 157 1 is be VBZ cord-289926-y1rjgbui 157 2 present present JJ cord-289926-y1rjgbui 157 3 in in IN cord-289926-y1rjgbui 157 4 plants plant NNS cord-289926-y1rjgbui 157 5 , , , cord-289926-y1rjgbui 157 6 yeast yeast NN cord-289926-y1rjgbui 157 7 and and CC cord-289926-y1rjgbui 157 8 animals animal NNS cord-289926-y1rjgbui 157 9 , , , cord-289926-y1rjgbui 157 10 and and CC cord-289926-y1rjgbui 157 11 is be VBZ cord-289926-y1rjgbui 157 12 characterized characterize VBN cord-289926-y1rjgbui 157 13 by by IN cord-289926-y1rjgbui 157 14 highly highly RB cord-289926-y1rjgbui 157 15 diverse diverse JJ cord-289926-y1rjgbui 157 16 sequences sequence NNS cord-289926-y1rjgbui 157 17 [ [ -LRB- cord-289926-y1rjgbui 157 18 31 31 CD cord-289926-y1rjgbui 157 19 ] ] -RRB- cord-289926-y1rjgbui 157 20 . . . cord-289926-y1rjgbui 158 1 Members member NNS cord-289926-y1rjgbui 158 2 of of IN cord-289926-y1rjgbui 158 3 the the DT cord-289926-y1rjgbui 158 4 HMG HMG NNP cord-289926-y1rjgbui 158 5 family family NN cord-289926-y1rjgbui 158 6 may may MD cord-289926-y1rjgbui 158 7 contain contain VB cord-289926-y1rjgbui 158 8 single single JJ cord-289926-y1rjgbui 158 9 or or CC cord-289926-y1rjgbui 158 10 multiple multiple JJ cord-289926-y1rjgbui 158 11 copies copy NNS cord-289926-y1rjgbui 158 12 of of IN cord-289926-y1rjgbui 158 13 the the DT cord-289926-y1rjgbui 158 14 HMG HMG NNP cord-289926-y1rjgbui 158 15 box box NN cord-289926-y1rjgbui 158 16 ; ; : cord-289926-y1rjgbui 158 17 some some DT cord-289926-y1rjgbui 158 18 members member NNS cord-289926-y1rjgbui 158 19 bind bind VBP cord-289926-y1rjgbui 158 20 DNA dna NN cord-289926-y1rjgbui 158 21 in in IN cord-289926-y1rjgbui 158 22 a a DT cord-289926-y1rjgbui 158 23 sequence sequence NN cord-289926-y1rjgbui 158 24 - - HYPH cord-289926-y1rjgbui 158 25 specific specific JJ cord-289926-y1rjgbui 158 26 manner manner NN cord-289926-y1rjgbui 158 27 , , , cord-289926-y1rjgbui 158 28 others other NNS cord-289926-y1rjgbui 158 29 bind bind VBP cord-289926-y1rjgbui 158 30 DNA DNA NNP cord-289926-y1rjgbui 158 31 non non NN cord-289926-y1rjgbui 158 32 - - JJ cord-289926-y1rjgbui 158 33 specifically specifically RB cord-289926-y1rjgbui 158 34 , , , cord-289926-y1rjgbui 158 35 and and CC cord-289926-y1rjgbui 158 36 yet yet RB cord-289926-y1rjgbui 158 37 others other NNS cord-289926-y1rjgbui 158 38 recognize recognize VBP cord-289926-y1rjgbui 158 39 and and CC cord-289926-y1rjgbui 158 40 bind bind VB cord-289926-y1rjgbui 158 41 to to IN cord-289926-y1rjgbui 158 42 distorted distorted JJ cord-289926-y1rjgbui 158 43 DNA dna NN cord-289926-y1rjgbui 158 44 -such -such NN cord-289926-y1rjgbui 158 45 as as IN cord-289926-y1rjgbui 158 46 4-way 4-way JJ cord-289926-y1rjgbui 158 47 junctions junction NNS cord-289926-y1rjgbui 158 48 or or CC cord-289926-y1rjgbui 158 49 cisplatinmodified cisplatinmodifie VBN cord-289926-y1rjgbui 158 50 DNA DNA NNP cord-289926-y1rjgbui 158 51 [ [ -LRB- cord-289926-y1rjgbui 158 52 38 38 CD cord-289926-y1rjgbui 158 53 ] ] -RRB- cord-289926-y1rjgbui 158 54 . . . cord-289926-y1rjgbui 159 1 In in IN cord-289926-y1rjgbui 159 2 all all DT cord-289926-y1rjgbui 159 3 known know VBN cord-289926-y1rjgbui 159 4 cases case NNS cord-289926-y1rjgbui 159 5 , , , cord-289926-y1rjgbui 159 6 the the DT cord-289926-y1rjgbui 159 7 binding binding NN cord-289926-y1rjgbui 159 8 of of IN cord-289926-y1rjgbui 159 9 HMG HMG NNP cord-289926-y1rjgbui 159 10 box box NN cord-289926-y1rjgbui 159 11 proteins protein NNS cord-289926-y1rjgbui 159 12 causes cause VBZ cord-289926-y1rjgbui 159 13 distortion distortion NN cord-289926-y1rjgbui 159 14 or or CC cord-289926-y1rjgbui 159 15 a a DT cord-289926-y1rjgbui 159 16 bend bend NN cord-289926-y1rjgbui 159 17 in in IN cord-289926-y1rjgbui 159 18 the the DT cord-289926-y1rjgbui 159 19 DNA dna NN cord-289926-y1rjgbui 159 20 [ [ -LRB- cord-289926-y1rjgbui 159 21 38 38 CD cord-289926-y1rjgbui 159 22 ] ] -RRB- cord-289926-y1rjgbui 159 23 . . . cord-289926-y1rjgbui 160 1 Our -PRON- PRP$ cord-289926-y1rjgbui 160 2 model model NN cord-289926-y1rjgbui 160 3 therefore therefore RB cord-289926-y1rjgbui 160 4 predicts predict VBZ cord-289926-y1rjgbui 160 5 that that IN cord-289926-y1rjgbui 160 6 HDAg HDAg NNS cord-289926-y1rjgbui 160 7 will will MD cord-289926-y1rjgbui 160 8 induce induce VB cord-289926-y1rjgbui 160 9 a a DT cord-289926-y1rjgbui 160 10 similar similar JJ cord-289926-y1rjgbui 160 11 bend bend NN cord-289926-y1rjgbui 160 12 when when WRB cord-289926-y1rjgbui 160 13 binding bind VBG cord-289926-y1rjgbui 160 14 to to IN cord-289926-y1rjgbui 160 15 the the DT cord-289926-y1rjgbui 160 16 HDV HDV NNP cord-289926-y1rjgbui 160 17 genome genome NN cord-289926-y1rjgbui 160 18 . . . cord-289926-y1rjgbui 161 1 HDAg HDAg NNP cord-289926-y1rjgbui 161 2 exhibits exhibit VBZ cord-289926-y1rjgbui 161 3 binding bind VBG cord-289926-y1rjgbui 161 4 specificity specificity NN cord-289926-y1rjgbui 161 5 which which WDT cord-289926-y1rjgbui 161 6 appears appear VBZ cord-289926-y1rjgbui 161 7 to to TO cord-289926-y1rjgbui 161 8 be be VB cord-289926-y1rjgbui 161 9 determined determine VBN cord-289926-y1rjgbui 161 10 primarily primarily RB cord-289926-y1rjgbui 161 11 by by IN cord-289926-y1rjgbui 161 12 the the DT cord-289926-y1rjgbui 161 13 structure structure NN cord-289926-y1rjgbui 161 14 of of IN cord-289926-y1rjgbui 161 15 the the DT cord-289926-y1rjgbui 161 16 HDV HDV NNP cord-289926-y1rjgbui 161 17 RNA RNA NNP cord-289926-y1rjgbui 161 18 . . . cord-289926-y1rjgbui 162 1 However however RB cord-289926-y1rjgbui 162 2 some some DT cord-289926-y1rjgbui 162 3 sequence sequence NN cord-289926-y1rjgbui 162 4 specificity specificity NN cord-289926-y1rjgbui 162 5 is be VBZ cord-289926-y1rjgbui 162 6 required require VBN cord-289926-y1rjgbui 162 7 , , , cord-289926-y1rjgbui 162 8 since since IN cord-289926-y1rjgbui 162 9 HDAg hdag NN cord-289926-y1rjgbui 162 10 binds bind VBZ cord-289926-y1rjgbui 162 11 specifically specifically RB cord-289926-y1rjgbui 162 12 to to IN cord-289926-y1rjgbui 162 13 both both CC cord-289926-y1rjgbui 162 14 a a DT cord-289926-y1rjgbui 162 15 rod rod NN cord-289926-y1rjgbui 162 16 - - HYPH cord-289926-y1rjgbui 162 17 like like JJ cord-289926-y1rjgbui 162 18 structure structure NN cord-289926-y1rjgbui 162 19 comprising comprise VBG cord-289926-y1rjgbui 162 20 the the DT cord-289926-y1rjgbui 162 21 entire entire JJ cord-289926-y1rjgbui 162 22 HDV HDV NNP cord-289926-y1rjgbui 162 23 genome genome NN cord-289926-y1rjgbui 162 24 , , , cord-289926-y1rjgbui 162 25 and and CC cord-289926-y1rjgbui 162 26 to to IN cord-289926-y1rjgbui 162 27 a a DT cord-289926-y1rjgbui 162 28 multiple multiple JJ cord-289926-y1rjgbui 162 29 stem stem NN cord-289926-y1rjgbui 162 30 - - HYPH cord-289926-y1rjgbui 162 31 and and CC cord-289926-y1rjgbui 162 32 - - HYPH cord-289926-y1rjgbui 162 33 loop loop NN cord-289926-y1rjgbui 162 34 structure structure NN cord-289926-y1rjgbui 162 35 formed form VBN cord-289926-y1rjgbui 162 36 by by IN cord-289926-y1rjgbui 162 37 the the DT cord-289926-y1rjgbui 162 38 fragment fragment NN cord-289926-y1rjgbui 162 39 containing contain VBG cord-289926-y1rjgbui 162 40 the the DT cord-289926-y1rjgbui 162 41 ribozyme ribozyme NN cord-289926-y1rjgbui 162 42 domain domain NN cord-289926-y1rjgbui 162 43 of of IN cord-289926-y1rjgbui 162 44 HDV HDV NNP cord-289926-y1rjgbui 162 45 , , , cord-289926-y1rjgbui 162 46 but but CC cord-289926-y1rjgbui 162 47 does do VBZ cord-289926-y1rjgbui 162 48 not not RB cord-289926-y1rjgbui 162 49 bind bind VB cord-289926-y1rjgbui 162 50 to to IN cord-289926-y1rjgbui 162 51 the the DT cord-289926-y1rjgbui 162 52 double double RB cord-289926-y1rjgbui 162 53 - - HYPH cord-289926-y1rjgbui 162 54 stranded strand VBN cord-289926-y1rjgbui 162 55 RNA RNA NNP cord-289926-y1rjgbui 162 56 derived derive VBN cord-289926-y1rjgbui 162 57 from from IN cord-289926-y1rjgbui 162 58 an an DT cord-289926-y1rjgbui 162 59 unrelated unrelated JJ cord-289926-y1rjgbui 162 60 coronavirus coronavirus NN cord-289926-y1rjgbui 162 61 ( ( -LRB- cord-289926-y1rjgbui 162 62 mouse mouse NNP cord-289926-y1rjgbui 162 63 hepatitis hepatitis NNP cord-289926-y1rjgbui 162 64 virus virus NN cord-289926-y1rjgbui 162 65 ) ) -RRB- cord-289926-y1rjgbui 162 66 [ [ -LRB- cord-289926-y1rjgbui 162 67 33 33 CD cord-289926-y1rjgbui 162 68 ] ] -RRB- cord-289926-y1rjgbui 162 69 . . . cord-289926-y1rjgbui 163 1 HMG HMG NNP cord-289926-y1rjgbui 163 2 proteins protein NNS cord-289926-y1rjgbui 163 3 can can MD cord-289926-y1rjgbui 163 4 be be VB cord-289926-y1rjgbui 163 5 divided divide VBN cord-289926-y1rjgbui 163 6 into into IN cord-289926-y1rjgbui 163 7 3 3 CD cord-289926-y1rjgbui 163 8 major major JJ cord-289926-y1rjgbui 163 9 groups group NNS cord-289926-y1rjgbui 163 10 based base VBN cord-289926-y1rjgbui 163 11 on on IN cord-289926-y1rjgbui 163 12 their -PRON- PRP$ cord-289926-y1rjgbui 163 13 size size NN cord-289926-y1rjgbui 163 14 , , , cord-289926-y1rjgbui 163 15 sequence sequence NN cord-289926-y1rjgbui 163 16 similarities similarity NNS cord-289926-y1rjgbui 163 17 and and CC cord-289926-y1rjgbui 163 18 DNA dna NN cord-289926-y1rjgbui 163 19 - - HYPH cord-289926-y1rjgbui 163 20 binding bind VBG cord-289926-y1rjgbui 163 21 properties property NNS cord-289926-y1rjgbui 163 22 : : : cord-289926-y1rjgbui 163 23 HMG-1/-2 HMG-1/-2 NNP cord-289926-y1rjgbui 163 24 , , , cord-289926-y1rjgbui 163 25 HMG-14/-17 hmg-14/-17 NN cord-289926-y1rjgbui 163 26 and and CC cord-289926-y1rjgbui 163 27 HMG HMG NNP cord-289926-y1rjgbui 164 1 -I -I NNP cord-289926-y1rjgbui 164 2 / / SYM cord-289926-y1rjgbui 164 3 Y Y NNP cord-289926-y1rjgbui 164 4 [ [ -LRB- cord-289926-y1rjgbui 164 5 2 2 CD cord-289926-y1rjgbui 164 6 ] ] -RRB- cord-289926-y1rjgbui 164 7 . . . cord-289926-y1rjgbui 165 1 The the DT cord-289926-y1rjgbui 165 2 SRY SRY NNP cord-289926-y1rjgbui 165 3 gene gene NN cord-289926-y1rjgbui 165 4 belongs belong VBZ cord-289926-y1rjgbui 165 5 to to IN cord-289926-y1rjgbui 165 6 the the DT cord-289926-y1rjgbui 165 7 HMG-1/-2 HMG-1/-2 NNP cord-289926-y1rjgbui 165 8 family family NN cord-289926-y1rjgbui 165 9 , , , cord-289926-y1rjgbui 165 10 which which WDT cord-289926-y1rjgbui 165 11 is be VBZ cord-289926-y1rjgbui 165 12 represented represent VBN cord-289926-y1rjgbui 165 13 by by IN cord-289926-y1rjgbui 165 14 the the DT cord-289926-y1rjgbui 165 15 HMG-1 HMG-1 NNP cord-289926-y1rjgbui 165 16 motif motif NN cord-289926-y1rjgbui 165 17 and and CC cord-289926-y1rjgbui 165 18 contains contain VBZ cord-289926-y1rjgbui 165 19 2 2 CD cord-289926-y1rjgbui 165 20 HMG HMG NNP cord-289926-y1rjgbui 165 21 boxes box NNS cord-289926-y1rjgbui 165 22 referred refer VBN cord-289926-y1rjgbui 165 23 as as IN cord-289926-y1rjgbui 165 24 HMG1.1 HMG1.1 NNP cord-289926-y1rjgbui 165 25 and and CC cord-289926-y1rjgbui 165 26 HMG1.2 HMG1.2 NNP cord-289926-y1rjgbui 165 27 . . . cord-289926-y1rjgbui 166 1 The the DT cord-289926-y1rjgbui 166 2 HMG HMG NNP cord-289926-y1rjgbui 166 3 box box NN cord-289926-y1rjgbui 166 4 of of IN cord-289926-y1rjgbui 166 5 SRY SRY NNP cord-289926-y1rjgbui 166 6 is be VBZ cord-289926-y1rjgbui 166 7 more more RBR cord-289926-y1rjgbui 166 8 similar similar JJ cord-289926-y1rjgbui 166 9 to to IN cord-289926-y1rjgbui 166 10 HMG1.2 HMG1.2 NNP cord-289926-y1rjgbui 166 11 , , , cord-289926-y1rjgbui 166 12 which which WDT cord-289926-y1rjgbui 166 13 is be VBZ cord-289926-y1rjgbui 166 14 the the DT cord-289926-y1rjgbui 166 15 most most RBS cord-289926-y1rjgbui 166 16 likely likely JJ cord-289926-y1rjgbui 166 17 candidate candidate NN cord-289926-y1rjgbui 166 18 for for IN cord-289926-y1rjgbui 166 19 an an DT cord-289926-y1rjgbui 166 20 ancestral ancestral JJ cord-289926-y1rjgbui 166 21 HMG1 HMG1 NNP cord-289926-y1rjgbui 166 22 box box NN cord-289926-y1rjgbui 166 23 [ [ -LRB- cord-289926-y1rjgbui 166 24 2 2 CD cord-289926-y1rjgbui 166 25 ] ] -RRB- cord-289926-y1rjgbui 166 26 . . . cord-289926-y1rjgbui 167 1 Ten ten CD cord-289926-y1rjgbui 167 2 of of IN cord-289926-y1rjgbui 167 3 17 17 CD cord-289926-y1rjgbui 167 4 identities identity NNS cord-289926-y1rjgbui 167 5 in in IN cord-289926-y1rjgbui 167 6 the the DT cord-289926-y1rjgbui 167 7 alignment alignment NN cord-289926-y1rjgbui 167 8 of of IN cord-289926-y1rjgbui 167 9 the the DT cord-289926-y1rjgbui 167 10 HMG HMG NNP cord-289926-y1rjgbui 167 11 box box NN cord-289926-y1rjgbui 167 12 of of IN cord-289926-y1rjgbui 167 13 SRY SRY NNP cord-289926-y1rjgbui 167 14 with with IN cord-289926-y1rjgbui 167 15 HMG1.2 HMG1.2 NNP cord-289926-y1rjgbui 167 16 are be VBP cord-289926-y1rjgbui 167 17 also also RB cord-289926-y1rjgbui 167 18 present present JJ cord-289926-y1rjgbui 167 19 in in IN cord-289926-y1rjgbui 167 20 its -PRON- PRP$ cord-289926-y1rjgbui 167 21 alignment alignment NN cord-289926-y1rjgbui 167 22 with with IN cord-289926-y1rjgbui 167 23 the the DT cord-289926-y1rjgbui 167 24 RNA RNA NNP cord-289926-y1rjgbui 167 25 - - HYPH cord-289926-y1rjgbui 167 26 binding bind VBG cord-289926-y1rjgbui 167 27 domain domain NN cord-289926-y1rjgbui 167 28 of of IN cord-289926-y1rjgbui 167 29 HDAg hdag NN cord-289926-y1rjgbui 167 30 , , , cord-289926-y1rjgbui 167 31 and and CC cord-289926-y1rjgbui 167 32 three three CD cord-289926-y1rjgbui 167 33 of of IN cord-289926-y1rjgbui 167 34 the the DT cord-289926-y1rjgbui 167 35 remaining remain VBG cord-289926-y1rjgbui 167 36 7 7 CD cord-289926-y1rjgbui 167 37 show show NN cord-289926-y1rjgbui 167 38 conservative conservative JJ cord-289926-y1rjgbui 167 39 substitutions substitution NNS cord-289926-y1rjgbui 167 40 ( ( -LRB- cord-289926-y1rjgbui 167 41 K k NN cord-289926-y1rjgbui 167 42 - - HYPH cord-289926-y1rjgbui 167 43 > > XX cord-289926-y1rjgbui 167 44 R r NN cord-289926-y1rjgbui 167 45 , , , cord-289926-y1rjgbui 167 46 A a NN cord-289926-y1rjgbui 167 47 - - HYPH cord-289926-y1rjgbui 167 48 > > NN cord-289926-y1rjgbui 167 49 G g NN cord-289926-y1rjgbui 167 50 , , , cord-289926-y1rjgbui 167 51 A A NNP cord-289926-y1rjgbui 167 52 ->L ->L NNP cord-289926-y1rjgbui 167 53 , , , cord-289926-y1rjgbui 167 54 Fig Fig NNP cord-289926-y1rjgbui 167 55 . . NNP cord-289926-y1rjgbui 167 56 3 3 CD cord-289926-y1rjgbui 167 57 ) ) -RRB- cord-289926-y1rjgbui 167 58 . . . cord-289926-y1rjgbui 168 1 Thus thus RB cord-289926-y1rjgbui 168 2 the the DT cord-289926-y1rjgbui 168 3 sequence sequence NN cord-289926-y1rjgbui 168 4 constraints constraint NNS cord-289926-y1rjgbui 168 5 upon upon IN cord-289926-y1rjgbui 168 6 the the DT cord-289926-y1rjgbui 168 7 RNAbinding rnabinding NN cord-289926-y1rjgbui 168 8 domain domain NN cord-289926-y1rjgbui 168 9 can can MD cord-289926-y1rjgbui 168 10 be be VB cord-289926-y1rjgbui 168 11 traced trace VBN cord-289926-y1rjgbui 168 12 back back RB cord-289926-y1rjgbui 168 13 through through IN cord-289926-y1rjgbui 168 14 the the DT cord-289926-y1rjgbui 168 15 most most RBS cord-289926-y1rjgbui 168 16 closely closely RB cord-289926-y1rjgbui 168 17 related related JJ cord-289926-y1rjgbui 168 18 HMG HMG NNP cord-289926-y1rjgbui 168 19 box box NN cord-289926-y1rjgbui 168 20 ( ( -LRB- cord-289926-y1rjgbui 168 21 of of IN cord-289926-y1rjgbui 168 22 SRY SRY NNP cord-289926-y1rjgbui 168 23 ) ) -RRB- cord-289926-y1rjgbui 168 24 to to IN cord-289926-y1rjgbui 168 25 the the DT cord-289926-y1rjgbui 168 26 ancestral ancestral JJ cord-289926-y1rjgbui 168 27 sequence sequence NN cord-289926-y1rjgbui 168 28 of of IN cord-289926-y1rjgbui 168 29 the the DT cord-289926-y1rjgbui 168 30 HMG-1 HMG-1 NNP cord-289926-y1rjgbui 168 31 family family NN cord-289926-y1rjgbui 168 32 . . . cord-289926-y1rjgbui 169 1 The the DT cord-289926-y1rjgbui 169 2 predicted predict VBN cord-289926-y1rjgbui 169 3 secondary secondary JJ cord-289926-y1rjgbui 169 4 structure structure NN cord-289926-y1rjgbui 169 5 of of IN cord-289926-y1rjgbui 169 6 HMG-1 HMG-1 NNP cord-289926-y1rjgbui 169 7 and and CC cord-289926-y1rjgbui 169 8 the the DT cord-289926-y1rjgbui 169 9 solution solution NN cord-289926-y1rjgbui 169 10 structure structure NN cord-289926-y1rjgbui 169 11 of of IN cord-289926-y1rjgbui 169 12 hamster hamster NN cord-289926-y1rjgbui 169 13 HMG1.2 HMG1.2 NNP cord-289926-y1rjgbui 169 14 have have VBP cord-289926-y1rjgbui 169 15 been be VBN cord-289926-y1rjgbui 169 16 determined determine VBN cord-289926-y1rjgbui 169 17 [ [ -LRB- cord-289926-y1rjgbui 169 18 38 38 CD cord-289926-y1rjgbui 169 19 ] ] -RRB- cord-289926-y1rjgbui 169 20 . . . cord-289926-y1rjgbui 170 1 The the DT cord-289926-y1rjgbui 170 2 structure structure NN cord-289926-y1rjgbui 170 3 consists consist VBZ cord-289926-y1rjgbui 170 4 of of IN cord-289926-y1rjgbui 170 5 a a DT cord-289926-y1rjgbui 170 6 stretch stretch NN cord-289926-y1rjgbui 170 7 of of IN cord-289926-y1rjgbui 170 8 basic basic JJ cord-289926-y1rjgbui 170 9 residues residue NNS cord-289926-y1rjgbui 170 10 followed follow VBN cord-289926-y1rjgbui 170 11 by by IN cord-289926-y1rjgbui 170 12 proline proline NN cord-289926-y1rjgbui 170 13 at at IN cord-289926-y1rjgbui 170 14 the the DT cord-289926-y1rjgbui 170 15 N n CD cord-289926-y1rjgbui 170 16 - - HYPH cord-289926-y1rjgbui 170 17 terminal terminal JJ cord-289926-y1rjgbui 170 18 end end NN cord-289926-y1rjgbui 170 19 , , , cord-289926-y1rjgbui 170 20 referred refer VBN cord-289926-y1rjgbui 170 21 by by IN cord-289926-y1rjgbui 170 22 the the DT cord-289926-y1rjgbui 170 23 authors author NNS cord-289926-y1rjgbui 170 24 as as IN cord-289926-y1rjgbui 170 25 the the DT cord-289926-y1rjgbui 170 26 ' ' `` cord-289926-y1rjgbui 170 27 terminal terminal JJ cord-289926-y1rjgbui 170 28 unit unit NN cord-289926-y1rjgbui 170 29 ' ' '' cord-289926-y1rjgbui 170 30 , , , cord-289926-y1rjgbui 170 31 and and CC cord-289926-y1rjgbui 170 32 3 3 CD cord-289926-y1rjgbui 170 33 ␣ ␣ ADD cord-289926-y1rjgbui 171 1 -helices -helices : cord-289926-y1rjgbui 171 2 ( ( -LRB- cord-289926-y1rjgbui 171 3 Fig Fig NNP cord-289926-y1rjgbui 171 4 . . . cord-289926-y1rjgbui 171 5 3 3 CD cord-289926-y1rjgbui 171 6 ) ) -RRB- cord-289926-y1rjgbui 171 7 . . . cord-289926-y1rjgbui 172 1 The the DT cord-289926-y1rjgbui 172 2 sequence sequence NN cord-289926-y1rjgbui 172 3 similarity similarity NN cord-289926-y1rjgbui 172 4 between between IN cord-289926-y1rjgbui 172 5 HMG-1 HMG-1 NNP cord-289926-y1rjgbui 172 6 and and CC cord-289926-y1rjgbui 172 7 the the DT cord-289926-y1rjgbui 172 8 RNA RNA NNP cord-289926-y1rjgbui 172 9 - - HYPH cord-289926-y1rjgbui 172 10 binding bind VBG cord-289926-y1rjgbui 172 11 domain domain NN cord-289926-y1rjgbui 172 12 of of IN cord-289926-y1rjgbui 172 13 HDAg hdag NN cord-289926-y1rjgbui 172 14 begins begin VBZ cord-289926-y1rjgbui 172 15 within within IN cord-289926-y1rjgbui 172 16 the the DT cord-289926-y1rjgbui 172 17 terminal terminal JJ cord-289926-y1rjgbui 172 18 unit unit NN cord-289926-y1rjgbui 172 19 and and CC cord-289926-y1rjgbui 172 20 continues continue VBZ cord-289926-y1rjgbui 172 21 through through IN cord-289926-y1rjgbui 172 22 first first JJ cord-289926-y1rjgbui 172 23 and and CC cord-289926-y1rjgbui 172 24 second second JJ cord-289926-y1rjgbui 173 1 ␣ ␣ NNP cord-289926-y1rjgbui 173 2 -helices -helices . cord-289926-y1rjgbui 174 1 ( ( -LRB- cord-289926-y1rjgbui 174 2 h1 h1 NNP cord-289926-y1rjgbui 174 3 and and CC cord-289926-y1rjgbui 174 4 h2 h2 NNP cord-289926-y1rjgbui 174 5 ) ) -RRB- cord-289926-y1rjgbui 174 6 . . . cord-289926-y1rjgbui 175 1 Together together RB cord-289926-y1rjgbui 175 2 , , , cord-289926-y1rjgbui 175 3 these these DT cord-289926-y1rjgbui 175 4 structures structure NNS cord-289926-y1rjgbui 175 5 comprise comprise VBP cord-289926-y1rjgbui 175 6 the the DT cord-289926-y1rjgbui 175 7 side side NN cord-289926-y1rjgbui 175 8 of of IN cord-289926-y1rjgbui 175 9 a a DT cord-289926-y1rjgbui 175 10 flat flat RB cord-289926-y1rjgbui 175 11 - - HYPH cord-289926-y1rjgbui 175 12 shaped shaped JJ cord-289926-y1rjgbui 175 13 arrowhead arrowhead NN cord-289926-y1rjgbui 175 14 which which WDT cord-289926-y1rjgbui 175 15 is be VBZ cord-289926-y1rjgbui 175 16 proposed propose VBN cord-289926-y1rjgbui 175 17 to to TO cord-289926-y1rjgbui 175 18 lie lie VB cord-289926-y1rjgbui 175 19 along along IN cord-289926-y1rjgbui 175 20 the the DT cord-289926-y1rjgbui 175 21 minor minor JJ cord-289926-y1rjgbui 175 22 groove groove NN cord-289926-y1rjgbui 175 23 and and CC cord-289926-y1rjgbui 175 24 continue continue VB cord-289926-y1rjgbui 175 25 into into IN cord-289926-y1rjgbui 175 26 the the DT cord-289926-y1rjgbui 175 27 major major JJ cord-289926-y1rjgbui 175 28 groove groove NN cord-289926-y1rjgbui 175 29 of of IN cord-289926-y1rjgbui 175 30 the the DT cord-289926-y1rjgbui 175 31 DNA dna NN cord-289926-y1rjgbui 175 32 [ [ -LRB- cord-289926-y1rjgbui 175 33 38 38 CD cord-289926-y1rjgbui 175 34 ] ] -RRB- cord-289926-y1rjgbui 175 35 . . . cord-289926-y1rjgbui 176 1 Interactions interaction NNS cord-289926-y1rjgbui 176 2 between between IN cord-289926-y1rjgbui 176 3 the the DT cord-289926-y1rjgbui 176 4 terminal terminal JJ cord-289926-y1rjgbui 176 5 unit unit NN cord-289926-y1rjgbui 176 6 and and CC cord-289926-y1rjgbui 176 7 the the DT cord-289926-y1rjgbui 176 8 DNA dna NN cord-289926-y1rjgbui 176 9 are be VBP cord-289926-y1rjgbui 176 10 absolutely absolutely RB cord-289926-y1rjgbui 176 11 essential essential JJ cord-289926-y1rjgbui 176 12 [ [ -LRB- cord-289926-y1rjgbui 176 13 38 38 CD cord-289926-y1rjgbui 176 14 ] ] -RRB- cord-289926-y1rjgbui 176 15 . . . cord-289926-y1rjgbui 177 1 The the DT cord-289926-y1rjgbui 177 2 sequence sequence NN cord-289926-y1rjgbui 177 3 of of IN cord-289926-y1rjgbui 177 4 the the DT cord-289926-y1rjgbui 177 5 terminal terminal JJ cord-289926-y1rjgbui 177 6 unit unit NN cord-289926-y1rjgbui 177 7 is be VBZ cord-289926-y1rjgbui 177 8 conserved conserve VBN cord-289926-y1rjgbui 177 9 between between IN cord-289926-y1rjgbui 177 10 SRY sry NN cord-289926-y1rjgbui 177 11 and and CC cord-289926-y1rjgbui 177 12 HDAg HDAg NNS cord-289926-y1rjgbui 177 13 , , , cord-289926-y1rjgbui 177 14 and and CC cord-289926-y1rjgbui 177 15 it -PRON- PRP cord-289926-y1rjgbui 177 16 is be VBZ cord-289926-y1rjgbui 177 17 also also RB cord-289926-y1rjgbui 177 18 similar similar JJ cord-289926-y1rjgbui 177 19 to to IN cord-289926-y1rjgbui 177 20 regions region NNS cord-289926-y1rjgbui 177 21 of of IN cord-289926-y1rjgbui 177 22 HMG1 HMG1 NNP cord-289926-y1rjgbui 177 23 / / SYM cord-289926-y1rjgbui 177 24 Y Y NNP cord-289926-y1rjgbui 177 25 proteins protein NNS cord-289926-y1rjgbui 177 26 , , , cord-289926-y1rjgbui 177 27 perhaps perhaps RB cord-289926-y1rjgbui 177 28 explaining explain VBG cord-289926-y1rjgbui 177 29 why why WRB cord-289926-y1rjgbui 177 30 a a DT cord-289926-y1rjgbui 177 31 database database NN cord-289926-y1rjgbui 177 32 search search NN cord-289926-y1rjgbui 177 33 with with IN cord-289926-y1rjgbui 177 34 the the DT cord-289926-y1rjgbui 177 35 RNA RNA NNP cord-289926-y1rjgbui 177 36 - - HYPH cord-289926-y1rjgbui 177 37 binding bind VBG cord-289926-y1rjgbui 177 38 domain domain NN cord-289926-y1rjgbui 177 39 of of IN cord-289926-y1rjgbui 177 40 HDAg HDAg NNS cord-289926-y1rjgbui 177 41 showed show VBD cord-289926-y1rjgbui 177 42 similarity similarity NN cord-289926-y1rjgbui 177 43 to to IN cord-289926-y1rjgbui 177 44 several several JJ cord-289926-y1rjgbui 177 45 HMGI HMGI NNP cord-289926-y1rjgbui 177 46 / / SYM cord-289926-y1rjgbui 177 47 Y Y NNP cord-289926-y1rjgbui 177 48 sequences sequence NNS cord-289926-y1rjgbui 177 49 ( ( -LRB- cord-289926-y1rjgbui 177 50 see see VB cord-289926-y1rjgbui 177 51 ' ' '' cord-289926-y1rjgbui 177 52 Database database NN cord-289926-y1rjgbui 177 53 searches search NNS cord-289926-y1rjgbui 177 54 ' ' POS cord-289926-y1rjgbui 177 55 section section NN cord-289926-y1rjgbui 177 56 in in IN cord-289926-y1rjgbui 177 57 Results result NNS cord-289926-y1rjgbui 177 58 ) ) -RRB- cord-289926-y1rjgbui 177 59 . . . cord-289926-y1rjgbui 178 1 Helix helix NN cord-289926-y1rjgbui 178 2 3 3 CD cord-289926-y1rjgbui 178 3 of of IN cord-289926-y1rjgbui 178 4 HMG-1 HMG-1 NNP cord-289926-y1rjgbui 178 5 comprises comprise VBZ cord-289926-y1rjgbui 178 6 the the DT cord-289926-y1rjgbui 178 7 other other JJ cord-289926-y1rjgbui 178 8 side side NN cord-289926-y1rjgbui 178 9 of of IN cord-289926-y1rjgbui 178 10 the the DT cord-289926-y1rjgbui 178 11 arrowhead arrowhead NN cord-289926-y1rjgbui 178 12 and and CC cord-289926-y1rjgbui 178 13 is be VBZ cord-289926-y1rjgbui 178 14 proposed propose VBN cord-289926-y1rjgbui 178 15 to to TO cord-289926-y1rjgbui 178 16 lie lie VB cord-289926-y1rjgbui 178 17 along along IN cord-289926-y1rjgbui 178 18 the the DT cord-289926-y1rjgbui 178 19 phosphodiester phosphodiester NN cord-289926-y1rjgbui 178 20 backbone backbone NN cord-289926-y1rjgbui 178 21 of of IN cord-289926-y1rjgbui 178 22 the the DT cord-289926-y1rjgbui 178 23 DNA dna NN cord-289926-y1rjgbui 178 24 [ [ -LRB- cord-289926-y1rjgbui 178 25 38 38 CD cord-289926-y1rjgbui 178 26 ] ] -RRB- cord-289926-y1rjgbui 178 27 ; ; : cord-289926-y1rjgbui 178 28 there there EX cord-289926-y1rjgbui 178 29 is be VBZ cord-289926-y1rjgbui 178 30 little little JJ cord-289926-y1rjgbui 178 31 sequence sequence NN cord-289926-y1rjgbui 178 32 similarity similarity NN cord-289926-y1rjgbui 178 33 between between IN cord-289926-y1rjgbui 178 34 this this DT cord-289926-y1rjgbui 178 35 helix helix NN cord-289926-y1rjgbui 178 36 and and CC cord-289926-y1rjgbui 178 37 HDAg hdag NN cord-289926-y1rjgbui 178 38 -there -there NN cord-289926-y1rjgbui 178 39 appears appear VBZ cord-289926-y1rjgbui 178 40 to to TO cord-289926-y1rjgbui 178 41 be be VB cord-289926-y1rjgbui 178 42 a a DT cord-289926-y1rjgbui 178 43 deletion deletion NN cord-289926-y1rjgbui 178 44 in in IN cord-289926-y1rjgbui 178 45 the the DT cord-289926-y1rjgbui 178 46 corresponding correspond VBG cord-289926-y1rjgbui 178 47 region region NN cord-289926-y1rjgbui 178 48 of of IN cord-289926-y1rjgbui 178 49 HDAg HDAg NNS cord-289926-y1rjgbui 178 50 . . . cord-289926-y1rjgbui 179 1 However however RB cord-289926-y1rjgbui 179 2 , , , cord-289926-y1rjgbui 179 3 the the DT cord-289926-y1rjgbui 179 4 region region NN cord-289926-y1rjgbui 179 5 immediately immediately RB cord-289926-y1rjgbui 179 6 following follow VBG cord-289926-y1rjgbui 179 7 helix helix NN cord-289926-y1rjgbui 179 8 3 3 CD cord-289926-y1rjgbui 179 9 has have VBZ cord-289926-y1rjgbui 179 10 a a DT cord-289926-y1rjgbui 179 11 stretch stretch NN cord-289926-y1rjgbui 179 12 of of IN cord-289926-y1rjgbui 179 13 basic basic JJ cord-289926-y1rjgbui 179 14 residues residue NNS cord-289926-y1rjgbui 179 15 that that WDT cord-289926-y1rjgbui 179 16 could could MD cord-289926-y1rjgbui 179 17 be be VB cord-289926-y1rjgbui 179 18 aligned align VBN cord-289926-y1rjgbui 179 19 with with IN cord-289926-y1rjgbui 179 20 the the DT cord-289926-y1rjgbui 179 21 right right JJ cord-289926-y1rjgbui 179 22 ARM arm NN cord-289926-y1rjgbui 179 23 of of IN cord-289926-y1rjgbui 179 24 the the DT cord-289926-y1rjgbui 179 25 RNA RNA NNP cord-289926-y1rjgbui 179 26 - - HYPH cord-289926-y1rjgbui 179 27 binding bind VBG cord-289926-y1rjgbui 179 28 domain domain NN cord-289926-y1rjgbui 179 29 of of IN cord-289926-y1rjgbui 179 30 HDAg hdag NN cord-289926-y1rjgbui 179 31 ( ( -LRB- cord-289926-y1rjgbui 179 32 Fig Fig NNP cord-289926-y1rjgbui 179 33 . . . cord-289926-y1rjgbui 179 34 3A 3A NNP cord-289926-y1rjgbui 179 35 ) ) -RRB- cord-289926-y1rjgbui 179 36 . . . cord-289926-y1rjgbui 180 1 It -PRON- PRP cord-289926-y1rjgbui 180 2 is be VBZ cord-289926-y1rjgbui 180 3 notable notable JJ cord-289926-y1rjgbui 180 4 that that IN cord-289926-y1rjgbui 180 5 the the DT cord-289926-y1rjgbui 180 6 residues residue NNS cord-289926-y1rjgbui 180 7 proposed propose VBN cord-289926-y1rjgbui 180 8 to to TO cord-289926-y1rjgbui 180 9 be be VB cord-289926-y1rjgbui 180 10 involved involve VBN cord-289926-y1rjgbui 180 11 in in IN cord-289926-y1rjgbui 180 12 contacting contact VBG cord-289926-y1rjgbui 180 13 DNA DNA NNP cord-289926-y1rjgbui 180 14 ( ( -LRB- cord-289926-y1rjgbui 180 15 terminal terminal JJ cord-289926-y1rjgbui 180 16 unit unit NN cord-289926-y1rjgbui 180 17 ) ) -RRB- cord-289926-y1rjgbui 180 18 and and CC cord-289926-y1rjgbui 180 19 those those DT cord-289926-y1rjgbui 180 20 whose whose WP$ cord-289926-y1rjgbui 180 21 substitution substitution NN cord-289926-y1rjgbui 180 22 is be VBZ cord-289926-y1rjgbui 180 23 likely likely JJ cord-289926-y1rjgbui 180 24 to to TO cord-289926-y1rjgbui 180 25 cause cause VB cord-289926-y1rjgbui 180 26 gross gross JJ cord-289926-y1rjgbui 180 27 structural structural JJ cord-289926-y1rjgbui 180 28 perturbations perturbation NNS cord-289926-y1rjgbui 180 29 ( ( -LRB- cord-289926-y1rjgbui 180 30 e.g. e.g. IN cord-289926-y1rjgbui 180 31 replacement replacement NN cord-289926-y1rjgbui 180 32 of of IN cord-289926-y1rjgbui 180 33 the the DT cord-289926-y1rjgbui 180 34 small small JJ cord-289926-y1rjgbui 180 35 residue residue NN cord-289926-y1rjgbui 180 36 at at IN cord-289926-y1rjgbui 180 37 position position NN cord-289926-y1rjgbui 180 38 40 40 CD cord-289926-y1rjgbui 180 39 , , , cord-289926-y1rjgbui 180 40 or or CC cord-289926-y1rjgbui 180 41 the the DT cord-289926-y1rjgbui 180 42 presence presence NN cord-289926-y1rjgbui 180 43 of of IN cord-289926-y1rjgbui 180 44 phenylalanine phenylalanine NN cord-289926-y1rjgbui 180 45 at at IN cord-289926-y1rjgbui 180 46 position position NN cord-289926-y1rjgbui 180 47 11 11 CD cord-289926-y1rjgbui 180 48 , , , cord-289926-y1rjgbui 180 49 Fig Fig NNP cord-289926-y1rjgbui 180 50 . . . cord-289926-y1rjgbui 180 51 _SP cord-289926-y1rjgbui 180 52 3 3 CD cord-289926-y1rjgbui 180 53 ) ) -RRB- cord-289926-y1rjgbui 180 54 are be VBP cord-289926-y1rjgbui 180 55 conserved conserve VBN cord-289926-y1rjgbui 180 56 among among IN cord-289926-y1rjgbui 180 57 the the DT cord-289926-y1rjgbui 180 58 HMG HMG NNP cord-289926-y1rjgbui 180 59 boxes box NNS cord-289926-y1rjgbui 180 60 of of IN cord-289926-y1rjgbui 180 61 SRY SRY NNP cord-289926-y1rjgbui 180 62 , , , cord-289926-y1rjgbui 180 63 HMG-1 HMG-1 NNP cord-289926-y1rjgbui 180 64 and and CC cord-289926-y1rjgbui 180 65 the the DT cord-289926-y1rjgbui 180 66 RNA RNA NNP cord-289926-y1rjgbui 180 67 - - HYPH cord-289926-y1rjgbui 180 68 binding bind VBG cord-289926-y1rjgbui 180 69 domain domain NN cord-289926-y1rjgbui 180 70 of of IN cord-289926-y1rjgbui 180 71 HDAg HDAg NNS cord-289926-y1rjgbui 180 72 . . . cord-289926-y1rjgbui 181 1 Gly-40 Gly-40 NNP cord-289926-y1rjgbui 181 2 is be VBZ cord-289926-y1rjgbui 181 3 proposed propose VBN cord-289926-y1rjgbui 181 4 to to TO cord-289926-y1rjgbui 181 5 pack pack VB cord-289926-y1rjgbui 181 6 closely closely RB cord-289926-y1rjgbui 181 7 to to IN cord-289926-y1rjgbui 181 8 Phe-10 Phe-10 NNP cord-289926-y1rjgbui 181 9 in in IN cord-289926-y1rjgbui 181 10 the the DT cord-289926-y1rjgbui 181 11 first first JJ cord-289926-y1rjgbui 181 12 helix helix NN cord-289926-y1rjgbui 181 13 in in IN cord-289926-y1rjgbui 181 14 the the DT cord-289926-y1rjgbui 181 15 resolved resolve VBN cord-289926-y1rjgbui 181 16 structure structure NN cord-289926-y1rjgbui 181 17 for for IN cord-289926-y1rjgbui 181 18 HMG1.2 HMG1.2 NNP cord-289926-y1rjgbui 181 19 of of IN cord-289926-y1rjgbui 181 20 hamster hamster NN cord-289926-y1rjgbui 181 21 [ [ -LRB- cord-289926-y1rjgbui 181 22 38 38 CD cord-289926-y1rjgbui 181 23 ] ] -RRB- cord-289926-y1rjgbui 181 24 . . . cord-289926-y1rjgbui 182 1 These these DT cord-289926-y1rjgbui 182 2 two two CD cord-289926-y1rjgbui 182 3 residues residue NNS cord-289926-y1rjgbui 182 4 are be VBP cord-289926-y1rjgbui 182 5 also also RB cord-289926-y1rjgbui 182 6 preserved preserve VBN cord-289926-y1rjgbui 182 7 within within IN cord-289926-y1rjgbui 182 8 the the DT cord-289926-y1rjgbui 182 9 RNA rna NN cord-289926-y1rjgbui 182 10 - - HYPH cord-289926-y1rjgbui 182 11 binding bind VBG cord-289926-y1rjgbui 182 12 domain domain NN cord-289926-y1rjgbui 182 13 of of IN cord-289926-y1rjgbui 182 14 HDAg HDAg NNS cord-289926-y1rjgbui 182 15 . . . cord-289926-y1rjgbui 183 1 On on IN cord-289926-y1rjgbui 183 2 the the DT cord-289926-y1rjgbui 183 3 other other JJ cord-289926-y1rjgbui 183 4 hand hand NN cord-289926-y1rjgbui 183 5 , , , cord-289926-y1rjgbui 183 6 many many JJ cord-289926-y1rjgbui 183 7 of of IN cord-289926-y1rjgbui 183 8 the the DT cord-289926-y1rjgbui 183 9 residues residue NNS cord-289926-y1rjgbui 183 10 involved involve VBN cord-289926-y1rjgbui 183 11 in in IN cord-289926-y1rjgbui 183 12 tertiary tertiary JJ cord-289926-y1rjgbui 183 13 folding folding NN cord-289926-y1rjgbui 183 14 of of IN cord-289926-y1rjgbui 183 15 the the DT cord-289926-y1rjgbui 183 16 HMG HMG NNP cord-289926-y1rjgbui 183 17 domain domain NN cord-289926-y1rjgbui 183 18 have have VBP cord-289926-y1rjgbui 183 19 been be VBN cord-289926-y1rjgbui 183 20 replaced replace VBN cord-289926-y1rjgbui 183 21 or or CC cord-289926-y1rjgbui 183 22 deleted delete VBN cord-289926-y1rjgbui 183 23 : : : cord-289926-y1rjgbui 183 24 in in IN cord-289926-y1rjgbui 183 25 the the DT cord-289926-y1rjgbui 183 26 RNA RNA NNP cord-289926-y1rjgbui 183 27 binding binding NN cord-289926-y1rjgbui 183 28 region region NN cord-289926-y1rjgbui 183 29 of of IN cord-289926-y1rjgbui 183 30 HDAg HDAg NNP cord-289926-y1rjgbui 184 1 the the DT cord-289926-y1rjgbui 184 2 N n CD cord-289926-y1rjgbui 184 3 - - HYPH cord-289926-y1rjgbui 184 4 terminal terminal JJ cord-289926-y1rjgbui 184 5 portion portion NN cord-289926-y1rjgbui 184 6 of of IN cord-289926-y1rjgbui 184 7 helix helix NN cord-289926-y1rjgbui 184 8 1 1 CD cord-289926-y1rjgbui 184 9 consists consist NNS cord-289926-y1rjgbui 184 10 of of IN cord-289926-y1rjgbui 184 11 polar polar JJ cord-289926-y1rjgbui 184 12 and and CC cord-289926-y1rjgbui 184 13 charged charge VBN cord-289926-y1rjgbui 184 14 residues residue NNS cord-289926-y1rjgbui 184 15 , , , cord-289926-y1rjgbui 184 16 while while IN cord-289926-y1rjgbui 184 17 the the DT cord-289926-y1rjgbui 184 18 same same JJ cord-289926-y1rjgbui 184 19 region region NN cord-289926-y1rjgbui 184 20 in in IN cord-289926-y1rjgbui 184 21 the the DT cord-289926-y1rjgbui 184 22 HMG HMG NNP cord-289926-y1rjgbui 184 23 box box NN cord-289926-y1rjgbui 184 24 is be VBZ cord-289926-y1rjgbui 184 25 hydrophobic hydrophobic JJ cord-289926-y1rjgbui 184 26 ( ( -LRB- cord-289926-y1rjgbui 184 27 Fig Fig NNP cord-289926-y1rjgbui 184 28 . . . cord-289926-y1rjgbui 184 29 3A 3A NNP cord-289926-y1rjgbui 184 30 ) ) -RRB- cord-289926-y1rjgbui 184 31 . . . cord-289926-y1rjgbui 185 1 Another another DT cord-289926-y1rjgbui 185 2 notable notable JJ cord-289926-y1rjgbui 185 3 feature feature NN cord-289926-y1rjgbui 185 4 is be VBZ cord-289926-y1rjgbui 185 5 the the DT cord-289926-y1rjgbui 185 6 lack lack NN cord-289926-y1rjgbui 185 7 of of IN cord-289926-y1rjgbui 185 8 tryptophan tryptophan NN cord-289926-y1rjgbui 185 9 residues residue NNS cord-289926-y1rjgbui 185 10 in in IN cord-289926-y1rjgbui 185 11 the the DT cord-289926-y1rjgbui 185 12 RNA RNA NNP cord-289926-y1rjgbui 185 13 - - HYPH cord-289926-y1rjgbui 185 14 binding bind VBG cord-289926-y1rjgbui 185 15 domain domain NN cord-289926-y1rjgbui 185 16 ( ( -LRB- cord-289926-y1rjgbui 185 17 SRY SRY NNP cord-289926-y1rjgbui 185 18 has have VBZ cord-289926-y1rjgbui 185 19 3 3 CD cord-289926-y1rjgbui 185 20 tryptophan tryptophan NN cord-289926-y1rjgbui 185 21 residues residue NNS cord-289926-y1rjgbui 185 22 , , , cord-289926-y1rjgbui 185 23 SOX3 SOX3 NNP cord-289926-y1rjgbui 185 24 has have VBZ cord-289926-y1rjgbui 185 25 2 2 CD cord-289926-y1rjgbui 185 26 tryptophan tryptophan NN cord-289926-y1rjgbui 185 27 residues residue NNS cord-289926-y1rjgbui 185 28 and and CC cord-289926-y1rjgbui 185 29 HMG-1 HMG-1 NNP cord-289926-y1rjgbui 185 30 has have VBZ cord-289926-y1rjgbui 185 31 1 1 CD cord-289926-y1rjgbui 185 32 tryptophan tryptophan NN cord-289926-y1rjgbui 185 33 residue residue NN cord-289926-y1rjgbui 185 34 ) ) -RRB- cord-289926-y1rjgbui 185 35 and and CC cord-289926-y1rjgbui 185 36 an an DT cord-289926-y1rjgbui 185 37 overall overall JJ cord-289926-y1rjgbui 185 38 lower low JJR cord-289926-y1rjgbui 185 39 percentage percentage NN cord-289926-y1rjgbui 185 40 of of IN cord-289926-y1rjgbui 185 41 the the DT cord-289926-y1rjgbui 185 42 hydrophobic hydrophobic JJ cord-289926-y1rjgbui 185 43 residues residue NNS cord-289926-y1rjgbui 185 44 . . . cord-289926-y1rjgbui 186 1 The the DT cord-289926-y1rjgbui 186 2 structure structure NN cord-289926-y1rjgbui 186 3 of of IN cord-289926-y1rjgbui 186 4 the the DT cord-289926-y1rjgbui 186 5 RNAbinding rnabinding NN cord-289926-y1rjgbui 186 6 domain domain NN cord-289926-y1rjgbui 186 7 of of IN cord-289926-y1rjgbui 186 8 HDAg hdag NN cord-289926-y1rjgbui 186 9 has have VBZ cord-289926-y1rjgbui 186 10 not not RB cord-289926-y1rjgbui 186 11 yet yet RB cord-289926-y1rjgbui 186 12 been be VBN cord-289926-y1rjgbui 186 13 determined determine VBN cord-289926-y1rjgbui 186 14 , , , cord-289926-y1rjgbui 186 15 but but CC cord-289926-y1rjgbui 186 16 a a DT cord-289926-y1rjgbui 186 17 computer computer NN cord-289926-y1rjgbui 186 18 generated generate VBD cord-289926-y1rjgbui 186 19 model model NN cord-289926-y1rjgbui 186 20 [ [ -LRB- cord-289926-y1rjgbui 186 21 47 47 CD cord-289926-y1rjgbui 186 22 ] ] -RRB- cord-289926-y1rjgbui 186 23 predicts predict VBZ cord-289926-y1rjgbui 186 24 a a DT cord-289926-y1rjgbui 186 25 helix helix NN cord-289926-y1rjgbui 186 26 - - HYPH cord-289926-y1rjgbui 186 27 loop loop NN cord-289926-y1rjgbui 186 28 - - HYPH cord-289926-y1rjgbui 186 29 helix helix NN cord-289926-y1rjgbui 186 30 structure structure NN cord-289926-y1rjgbui 186 31 in in IN cord-289926-y1rjgbui 186 32 which which WDT cord-289926-y1rjgbui 186 33 the the DT cord-289926-y1rjgbui 186 34 first first JJ cord-289926-y1rjgbui 186 35 helix helix NN cord-289926-y1rjgbui 186 36 covers cover VBZ cord-289926-y1rjgbui 186 37 regions region NNS cord-289926-y1rjgbui 186 38 corresponding correspond VBG cord-289926-y1rjgbui 186 39 to to IN cord-289926-y1rjgbui 186 40 helix helix NN cord-289926-y1rjgbui 186 41 1 1 CD cord-289926-y1rjgbui 186 42 and and CC cord-289926-y1rjgbui 186 43 part part NN cord-289926-y1rjgbui 186 44 of of IN cord-289926-y1rjgbui 186 45 helix helix NN cord-289926-y1rjgbui 186 46 2 2 CD cord-289926-y1rjgbui 186 47 of of IN cord-289926-y1rjgbui 186 48 HMG-1 HMG-1 NNP cord-289926-y1rjgbui 186 49 , , , cord-289926-y1rjgbui 186 50 while while IN cord-289926-y1rjgbui 186 51 the the DT cord-289926-y1rjgbui 186 52 second second JJ cord-289926-y1rjgbui 186 53 helix helix NN cord-289926-y1rjgbui 186 54 of of IN cord-289926-y1rjgbui 186 55 the the DT cord-289926-y1rjgbui 186 56 RNA RNA NNP cord-289926-y1rjgbui 186 57 - - HYPH cord-289926-y1rjgbui 186 58 binding bind VBG cord-289926-y1rjgbui 186 59 domain domain NN cord-289926-y1rjgbui 186 60 corresponds correspond VBZ cord-289926-y1rjgbui 186 61 to to IN cord-289926-y1rjgbui 186 62 helix helix NN cord-289926-y1rjgbui 186 63 3 3 CD cord-289926-y1rjgbui 186 64 of of IN cord-289926-y1rjgbui 186 65 HMG-1 hmg-1 NN cord-289926-y1rjgbui 187 1 ( ( -LRB- cord-289926-y1rjgbui 187 2 Fig Fig NNP cord-289926-y1rjgbui 187 3 . . . cord-289926-y1rjgbui 187 4 3C 3C NNP cord-289926-y1rjgbui 187 5 ) ) -RRB- cord-289926-y1rjgbui 187 6 . . . cord-289926-y1rjgbui 188 1 Based base VBN cord-289926-y1rjgbui 188 2 on on IN cord-289926-y1rjgbui 188 3 the the DT cord-289926-y1rjgbui 188 4 sequence sequence NN cord-289926-y1rjgbui 188 5 similarities similarity NNS cord-289926-y1rjgbui 188 6 discussed discuss VBN cord-289926-y1rjgbui 188 7 above above IN cord-289926-y1rjgbui 188 8 we -PRON- PRP cord-289926-y1rjgbui 188 9 suggest suggest VBP cord-289926-y1rjgbui 188 10 that that IN cord-289926-y1rjgbui 188 11 the the DT cord-289926-y1rjgbui 188 12 DNAbinding dnabinding NN cord-289926-y1rjgbui 188 13 domain domain NN cord-289926-y1rjgbui 188 14 of of IN cord-289926-y1rjgbui 188 15 SRY SRY NNP cord-289926-y1rjgbui 188 16 has have VBZ cord-289926-y1rjgbui 188 17 evolved evolve VBN cord-289926-y1rjgbui 188 18 into into IN cord-289926-y1rjgbui 188 19 the the DT cord-289926-y1rjgbui 188 20 RNA RNA NNP cord-289926-y1rjgbui 188 21 - - HYPH cord-289926-y1rjgbui 188 22 binding bind VBG cord-289926-y1rjgbui 188 23 domain domain NN cord-289926-y1rjgbui 188 24 of of IN cord-289926-y1rjgbui 188 25 HDAg HDAg NNS cord-289926-y1rjgbui 188 26 . . . cord-289926-y1rjgbui 189 1 This this DT cord-289926-y1rjgbui 189 2 particular particular JJ cord-289926-y1rjgbui 189 3 case case NN cord-289926-y1rjgbui 189 4 is be VBZ cord-289926-y1rjgbui 189 5 hardly hardly RB cord-289926-y1rjgbui 189 6 unique unique JJ cord-289926-y1rjgbui 189 7 : : : cord-289926-y1rjgbui 189 8 many many JJ cord-289926-y1rjgbui 189 9 recent recent JJ cord-289926-y1rjgbui 189 10 publications publication NNS cord-289926-y1rjgbui 189 11 report report VBP cord-289926-y1rjgbui 189 12 proteins protein NNS cord-289926-y1rjgbui 189 13 that that WDT cord-289926-y1rjgbui 189 14 bind bind VBP cord-289926-y1rjgbui 189 15 to to IN cord-289926-y1rjgbui 189 16 both both CC cord-289926-y1rjgbui 189 17 DNA DNA NNP cord-289926-y1rjgbui 189 18 and and CC cord-289926-y1rjgbui 189 19 RNA RNA NNP cord-289926-y1rjgbui 189 20 . . . cord-289926-y1rjgbui 190 1 Among among IN cord-289926-y1rjgbui 190 2 such such JJ cord-289926-y1rjgbui 190 3 proteins protein NNS cord-289926-y1rjgbui 190 4 are be VBP cord-289926-y1rjgbui 190 5 : : : cord-289926-y1rjgbui 190 6 DNA dna NN cord-289926-y1rjgbui 190 7 - - HYPH cord-289926-y1rjgbui 190 8 binding bind VBG cord-289926-y1rjgbui 190 9 protein protein NN cord-289926-y1rjgbui 190 10 SSAP SSAP NNP cord-289926-y1rjgbui 190 11 , , , cord-289926-y1rjgbui 190 12 which which WDT cord-289926-y1rjgbui 190 13 contains contain VBZ cord-289926-y1rjgbui 190 14 an an DT cord-289926-y1rjgbui 190 15 RNA RNA NNP cord-289926-y1rjgbui 190 16 Recognition recognition NN cord-289926-y1rjgbui 190 17 Motif motif NN cord-289926-y1rjgbui 190 18 ( ( -LRB- cord-289926-y1rjgbui 190 19 RRM rrm NN cord-289926-y1rjgbui 190 20 ) ) -RRB- cord-289926-y1rjgbui 190 21 and and CC cord-289926-y1rjgbui 190 22 specifically specifically RB cord-289926-y1rjgbui 190 23 binds bind VBZ cord-289926-y1rjgbui 190 24 to to IN cord-289926-y1rjgbui 190 25 the the DT cord-289926-y1rjgbui 190 26 enhancer enhancer NN cord-289926-y1rjgbui 190 27 region region NN cord-289926-y1rjgbui 190 28 of of IN cord-289926-y1rjgbui 190 29 sea sea NN cord-289926-y1rjgbui 190 30 urchin urchin NN cord-289926-y1rjgbui 190 31 histone histone NN cord-289926-y1rjgbui 190 32 H1 H1 NNP cord-289926-y1rjgbui 190 33 [ [ -LRB- cord-289926-y1rjgbui 190 34 13 13 CD cord-289926-y1rjgbui 190 35 ] ] -RRB- cord-289926-y1rjgbui 190 36 , , , cord-289926-y1rjgbui 190 37 human human JJ cord-289926-y1rjgbui 190 38 transcriptional transcriptional JJ cord-289926-y1rjgbui 190 39 activator activator NN cord-289926-y1rjgbui 190 40 p54nrb p54nrb NNP cord-289926-y1rjgbui 190 41 which which WDT cord-289926-y1rjgbui 190 42 binds bind VBZ cord-289926-y1rjgbui 190 43 both both DT cord-289926-y1rjgbui 190 44 DNA dna NN cord-289926-y1rjgbui 190 45 and and CC cord-289926-y1rjgbui 190 46 pre pre JJ cord-289926-y1rjgbui 190 47 - - JJ cord-289926-y1rjgbui 190 48 mRNA mrna JJ cord-289926-y1rjgbui 190 49 [ [ -LRB- cord-289926-y1rjgbui 190 50 1 1 CD cord-289926-y1rjgbui 190 51 ] ] -RRB- cord-289926-y1rjgbui 190 52 , , , cord-289926-y1rjgbui 190 53 mammalian mammalian JJ cord-289926-y1rjgbui 190 54 protein protein NN cord-289926-y1rjgbui 190 55 H16 H16 NNP cord-289926-y1rjgbui 190 56 which which WDT cord-289926-y1rjgbui 190 57 binds bind VBZ cord-289926-y1rjgbui 190 58 to to IN cord-289926-y1rjgbui 190 59 single single JJ cord-289926-y1rjgbui 190 60 stranded strand VBN cord-289926-y1rjgbui 190 61 DNA dna NN cord-289926-y1rjgbui 190 62 and and CC cord-289926-y1rjgbui 190 63 to to IN cord-289926-y1rjgbui 190 64 the the DT cord-289926-y1rjgbui 190 65 corresponding correspond VBG cord-289926-y1rjgbui 190 66 RNA RNA NNP cord-289926-y1rjgbui 190 67 sequence sequence NN cord-289926-y1rjgbui 190 68 [ [ -LRB- cord-289926-y1rjgbui 190 69 23 23 CD cord-289926-y1rjgbui 190 70 ] ] -RRB- cord-289926-y1rjgbui 190 71 , , , cord-289926-y1rjgbui 190 72 and and CC cord-289926-y1rjgbui 190 73 Y Y NNP cord-289926-y1rjgbui 190 74 - - HYPH cord-289926-y1rjgbui 190 75 box box NN cord-289926-y1rjgbui 190 76 proteins protein NNS cord-289926-y1rjgbui 190 77 which which WDT cord-289926-y1rjgbui 190 78 recognize recognize VBP cord-289926-y1rjgbui 190 79 both both CC cord-289926-y1rjgbui 190 80 RNA RNA NNP cord-289926-y1rjgbui 190 81 and and CC cord-289926-y1rjgbui 190 82 DNA DNA NNP cord-289926-y1rjgbui 190 83 [ [ -LRB- cord-289926-y1rjgbui 190 84 48 48 CD cord-289926-y1rjgbui 190 85 ] ] -RRB- cord-289926-y1rjgbui 190 86 . . . cord-289926-y1rjgbui 191 1 Two two CD cord-289926-y1rjgbui 191 2 RNA rna NN cord-289926-y1rjgbui 191 3 - - HYPH cord-289926-y1rjgbui 191 4 binding bind VBG cord-289926-y1rjgbui 191 5 proteins protein NNS cord-289926-y1rjgbui 191 6 have have VBP cord-289926-y1rjgbui 191 7 been be VBN cord-289926-y1rjgbui 191 8 shown show VBN cord-289926-y1rjgbui 191 9 to to TO cord-289926-y1rjgbui 191 10 have have VB cord-289926-y1rjgbui 191 11 a a DT cord-289926-y1rjgbui 191 12 similar similar JJ cord-289926-y1rjgbui 191 13 structure structure NN cord-289926-y1rjgbui 191 14 to to IN cord-289926-y1rjgbui 191 15 that that DT cord-289926-y1rjgbui 191 16 of of IN cord-289926-y1rjgbui 191 17 DNA dna NN cord-289926-y1rjgbui 191 18 binding binding NN cord-289926-y1rjgbui 191 19 domains domain NNS cord-289926-y1rjgbui 191 20 : : : cord-289926-y1rjgbui 191 21 ribosomal ribosomal JJ cord-289926-y1rjgbui 191 22 protein protein NN cord-289926-y1rjgbui 191 23 S7 S7 NNP cord-289926-y1rjgbui 191 24 appears appear VBZ cord-289926-y1rjgbui 191 25 to to TO cord-289926-y1rjgbui 191 26 have have VB cord-289926-y1rjgbui 191 27 a a DT cord-289926-y1rjgbui 191 28 pair pair NN cord-289926-y1rjgbui 191 29 of of IN cord-289926-y1rjgbui 191 30 helix helix NN cord-289926-y1rjgbui 191 31 - - HYPH cord-289926-y1rjgbui 191 32 turn turn NN cord-289926-y1rjgbui 191 33 - - HYPH cord-289926-y1rjgbui 191 34 helix helix NN cord-289926-y1rjgbui 191 35 motifs motif NNS cord-289926-y1rjgbui 191 36 similar similar JJ cord-289926-y1rjgbui 191 37 to to IN cord-289926-y1rjgbui 191 38 DNA dna NN cord-289926-y1rjgbui 191 39 architectural architectural JJ cord-289926-y1rjgbui 191 40 factors factor NNS cord-289926-y1rjgbui 191 41 [ [ -LRB- cord-289926-y1rjgbui 191 42 28 28 CD cord-289926-y1rjgbui 191 43 ] ] -RRB- cord-289926-y1rjgbui 191 44 and and CC cord-289926-y1rjgbui 191 45 the the DT cord-289926-y1rjgbui 191 46 ribosomal ribosomal JJ cord-289926-y1rjgbui 191 47 protein protein NN cord-289926-y1rjgbui 191 48 L11 L11 NNP cord-289926-y1rjgbui 191 49 contains contain VBZ cord-289926-y1rjgbui 191 50 3 3 CD cord-289926-y1rjgbui 192 1 ␣ ␣ NNP cord-289926-y1rjgbui 192 2 -helices -helices . cord-289926-y1rjgbui 193 1 and and CC cord-289926-y1rjgbui 193 2 is be VBZ cord-289926-y1rjgbui 193 3 similar similar JJ cord-289926-y1rjgbui 193 4 to to IN cord-289926-y1rjgbui 193 5 homeodomain homeodomain NNP cord-289926-y1rjgbui 193 6 proteins protein NNS cord-289926-y1rjgbui 193 7 [ [ -LRB- cord-289926-y1rjgbui 193 8 50 50 CD cord-289926-y1rjgbui 193 9 ] ] -RRB- cord-289926-y1rjgbui 193 10 . . . cord-289926-y1rjgbui 194 1 On on IN cord-289926-y1rjgbui 194 2 the the DT cord-289926-y1rjgbui 194 3 reciprocal reciprocal JJ cord-289926-y1rjgbui 194 4 side side NN cord-289926-y1rjgbui 194 5 , , , cord-289926-y1rjgbui 194 6 the the DT cord-289926-y1rjgbui 194 7 homeodomain homeodomain NN cord-289926-y1rjgbui 194 8 of of IN cord-289926-y1rjgbui 194 9 the the DT cord-289926-y1rjgbui 194 10 Drosophila Drosophila NNP cord-289926-y1rjgbui 194 11 bicoid bicoid NN cord-289926-y1rjgbui 194 12 protein protein NN cord-289926-y1rjgbui 194 13 has have VBZ cord-289926-y1rjgbui 194 14 been be VBN cord-289926-y1rjgbui 194 15 shown show VBN cord-289926-y1rjgbui 194 16 to to TO cord-289926-y1rjgbui 194 17 interact interact VB cord-289926-y1rjgbui 194 18 in in IN cord-289926-y1rjgbui 194 19 a a DT cord-289926-y1rjgbui 194 20 sequence sequence NN cord-289926-y1rjgbui 194 21 - - HYPH cord-289926-y1rjgbui 194 22 specific specific JJ cord-289926-y1rjgbui 194 23 manner manner NN cord-289926-y1rjgbui 194 24 with with IN cord-289926-y1rjgbui 194 25 3 3 CD cord-289926-y1rjgbui 194 26 -untranslated -untranslated JJ cord-289926-y1rjgbui 194 27 region region NN cord-289926-y1rjgbui 194 28 of of IN cord-289926-y1rjgbui 194 29 the the DT cord-289926-y1rjgbui 194 30 caudal caudal JJ cord-289926-y1rjgbui 194 31 gene gene NN cord-289926-y1rjgbui 194 32 transcript transcript NN cord-289926-y1rjgbui 194 33 [ [ -LRB- cord-289926-y1rjgbui 194 34 6 6 CD cord-289926-y1rjgbui 194 35 , , , cord-289926-y1rjgbui 194 36 14 14 CD cord-289926-y1rjgbui 194 37 ] ] -RRB- cord-289926-y1rjgbui 194 38 . . . cord-289926-y1rjgbui 195 1 Both both DT cord-289926-y1rjgbui 195 2 DNA dna NN cord-289926-y1rjgbui 195 3 - - HYPH cord-289926-y1rjgbui 195 4 binding binding JJ cord-289926-y1rjgbui 195 5 and and CC cord-289926-y1rjgbui 195 6 RNA rna NN cord-289926-y1rjgbui 195 7 - - HYPH cord-289926-y1rjgbui 195 8 binding bind VBG cord-289926-y1rjgbui 195 9 domains domain NNS cord-289926-y1rjgbui 195 10 often often RB cord-289926-y1rjgbui 195 11 interact interact VBP cord-289926-y1rjgbui 195 12 with with IN cord-289926-y1rjgbui 195 13 nucleic nucleic JJ cord-289926-y1rjgbui 195 14 acids acid NNS cord-289926-y1rjgbui 195 15 using use VBG cord-289926-y1rjgbui 195 16 ␣ ␣ ADD cord-289926-y1rjgbui 195 17 -helical -helical JJ cord-289926-y1rjgbui 195 18 structures structure NNS cord-289926-y1rjgbui 195 19 . . . cord-289926-y1rjgbui 196 1 While while IN cord-289926-y1rjgbui 196 2 both both CC cord-289926-y1rjgbui 196 3 the the DT cord-289926-y1rjgbui 196 4 major major JJ cord-289926-y1rjgbui 196 5 and and CC cord-289926-y1rjgbui 196 6 minor minor JJ cord-289926-y1rjgbui 196 7 grooves groove NNS cord-289926-y1rjgbui 196 8 of of IN cord-289926-y1rjgbui 196 9 regular regular JJ cord-289926-y1rjgbui 196 10 A a DT cord-289926-y1rjgbui 196 11 - - HYPH cord-289926-y1rjgbui 196 12 form form NN cord-289926-y1rjgbui 196 13 RNA RNA NNP cord-289926-y1rjgbui 196 14 are be VBP cord-289926-y1rjgbui 196 15 too too RB cord-289926-y1rjgbui 196 16 narrow narrow JJ cord-289926-y1rjgbui 196 17 to to TO cord-289926-y1rjgbui 196 18 permit permit VB cord-289926-y1rjgbui 196 19 a a DT cord-289926-y1rjgbui 196 20 direct direct JJ cord-289926-y1rjgbui 196 21 interaction interaction NN cord-289926-y1rjgbui 196 22 with with IN cord-289926-y1rjgbui 196 23 an an DT cord-289926-y1rjgbui 196 24 ␣ ␣ NN cord-289926-y1rjgbui 196 25 -helix -helix NN cord-289926-y1rjgbui 196 26 , , , cord-289926-y1rjgbui 196 27 bulges bulge NNS cord-289926-y1rjgbui 196 28 and and CC cord-289926-y1rjgbui 196 29 mismatches mismatch NNS cord-289926-y1rjgbui 196 30 considerably considerably RB cord-289926-y1rjgbui 196 31 alter alter VBP cord-289926-y1rjgbui 196 32 the the DT cord-289926-y1rjgbui 196 33 groove groove NN cord-289926-y1rjgbui 196 34 dimensions dimension NNS cord-289926-y1rjgbui 196 35 allowing allow VBG cord-289926-y1rjgbui 196 36 sufficient sufficient JJ cord-289926-y1rjgbui 196 37 contact contact NN cord-289926-y1rjgbui 196 38 surface surface NN cord-289926-y1rjgbui 196 39 with with IN cord-289926-y1rjgbui 196 40 an an DT cord-289926-y1rjgbui 196 41 ␣ ␣ NN cord-289926-y1rjgbui 196 42 -helix -helix JJ cord-289926-y1rjgbui 196 43 [ [ -LRB- cord-289926-y1rjgbui 196 44 41 41 CD cord-289926-y1rjgbui 196 45 ] ] -RRB- cord-289926-y1rjgbui 196 46 . . . cord-289926-y1rjgbui 197 1 The the DT cord-289926-y1rjgbui 197 2 HMG HMG NNP cord-289926-y1rjgbui 197 3 box box NN cord-289926-y1rjgbui 197 4 has have VBZ cord-289926-y1rjgbui 197 5 not not RB cord-289926-y1rjgbui 197 6 been be VBN cord-289926-y1rjgbui 197 7 reported report VBN cord-289926-y1rjgbui 197 8 to to TO cord-289926-y1rjgbui 197 9 bind bind VB cord-289926-y1rjgbui 197 10 RNA RNA NNP cord-289926-y1rjgbui 197 11 , , , cord-289926-y1rjgbui 197 12 however however RB cord-289926-y1rjgbui 197 13 it -PRON- PRP cord-289926-y1rjgbui 197 14 binds bind VBZ cord-289926-y1rjgbui 197 15 both both CC cord-289926-y1rjgbui 197 16 double double JJ cord-289926-y1rjgbui 197 17 - - HYPH cord-289926-y1rjgbui 197 18 and and CC cord-289926-y1rjgbui 197 19 single single RB cord-289926-y1rjgbui 197 20 - - HYPH cord-289926-y1rjgbui 197 21 stranded strand VBN cord-289926-y1rjgbui 197 22 DNA dna NN cord-289926-y1rjgbui 197 23 [ [ -LRB- cord-289926-y1rjgbui 197 24 16 16 CD cord-289926-y1rjgbui 197 25 ] ] -RRB- cord-289926-y1rjgbui 197 26 . . . cord-289926-y1rjgbui 198 1 Proteins protein NNS cord-289926-y1rjgbui 198 2 containing contain VBG cord-289926-y1rjgbui 198 3 an an DT cord-289926-y1rjgbui 198 4 HMG HMG NNP cord-289926-y1rjgbui 198 5 domain domain NN cord-289926-y1rjgbui 198 6 have have VBP cord-289926-y1rjgbui 198 7 widely widely RB cord-289926-y1rjgbui 198 8 diverse diverse JJ cord-289926-y1rjgbui 198 9 cellular cellular JJ cord-289926-y1rjgbui 198 10 roles role NNS cord-289926-y1rjgbui 198 11 , , , cord-289926-y1rjgbui 198 12 indicating indicate VBG cord-289926-y1rjgbui 198 13 that that IN cord-289926-y1rjgbui 198 14 an an DT cord-289926-y1rjgbui 198 15 HMG HMG NNP cord-289926-y1rjgbui 198 16 domain domain NN cord-289926-y1rjgbui 198 17 participates participate VBZ cord-289926-y1rjgbui 198 18 in in IN cord-289926-y1rjgbui 198 19 a a DT cord-289926-y1rjgbui 198 20 variety variety NN cord-289926-y1rjgbui 198 21 of of IN cord-289926-y1rjgbui 198 22 DNA dna NN cord-289926-y1rjgbui 198 23 - - HYPH cord-289926-y1rjgbui 198 24 protein protein NN cord-289926-y1rjgbui 198 25 interactions interaction NNS cord-289926-y1rjgbui 198 26 . . . cord-289926-y1rjgbui 199 1 It -PRON- PRP cord-289926-y1rjgbui 199 2 is be VBZ cord-289926-y1rjgbui 199 3 conceivable conceivable JJ cord-289926-y1rjgbui 199 4 that that IN cord-289926-y1rjgbui 199 5 the the DT cord-289926-y1rjgbui 199 6 wide wide JJ cord-289926-y1rjgbui 199 7 DNA dna NN cord-289926-y1rjgbui 199 8 - - HYPH cord-289926-y1rjgbui 199 9 binding bind VBG cord-289926-y1rjgbui 199 10 range range NN cord-289926-y1rjgbui 199 11 of of IN cord-289926-y1rjgbui 199 12 the the DT cord-289926-y1rjgbui 199 13 HMG HMG NNP cord-289926-y1rjgbui 199 14 domain domain NN cord-289926-y1rjgbui 199 15 could could MD cord-289926-y1rjgbui 199 16 extend extend VB cord-289926-y1rjgbui 199 17 to to IN cord-289926-y1rjgbui 199 18 RNA RNA NNP cord-289926-y1rjgbui 199 19 - - HYPH cord-289926-y1rjgbui 199 20 binding binding NN cord-289926-y1rjgbui 199 21 , , , cord-289926-y1rjgbui 199 22 especially especially RB cord-289926-y1rjgbui 199 23 considering consider VBG cord-289926-y1rjgbui 199 24 the the DT cord-289926-y1rjgbui 199 25 high high JJ cord-289926-y1rjgbui 199 26 rates rate NNS cord-289926-y1rjgbui 199 27 of of IN cord-289926-y1rjgbui 199 28 mutation mutation NN cord-289926-y1rjgbui 199 29 and and CC cord-289926-y1rjgbui 199 30 selection selection NN cord-289926-y1rjgbui 199 31 existing exist VBG cord-289926-y1rjgbui 199 32 in in IN cord-289926-y1rjgbui 199 33 the the DT cord-289926-y1rjgbui 199 34 virus virus NN cord-289926-y1rjgbui 199 35 . . . cord-289926-y1rjgbui 200 1 The the DT cord-289926-y1rjgbui 200 2 basic basic JJ cord-289926-y1rjgbui 200 3 stretches stretch NNS cord-289926-y1rjgbui 200 4 of of IN cord-289926-y1rjgbui 200 5 the the DT cord-289926-y1rjgbui 200 6 RNA RNA NNP cord-289926-y1rjgbui 200 7 - - HYPH cord-289926-y1rjgbui 200 8 binding bind VBG cord-289926-y1rjgbui 200 9 domain domain NN cord-289926-y1rjgbui 200 10 are be VBP cord-289926-y1rjgbui 200 11 similar similar JJ cord-289926-y1rjgbui 200 12 to to IN cord-289926-y1rjgbui 200 13 the the DT cord-289926-y1rjgbui 200 14 argininerich argininerich NNP cord-289926-y1rjgbui 200 15 motifs motif NNS cord-289926-y1rjgbui 200 16 ( ( -LRB- cord-289926-y1rjgbui 200 17 ARMs arm NNS cord-289926-y1rjgbui 200 18 ) ) -RRB- cord-289926-y1rjgbui 200 19 found find VBN cord-289926-y1rjgbui 200 20 in in IN cord-289926-y1rjgbui 200 21 the the DT cord-289926-y1rjgbui 200 22 products product NNS cord-289926-y1rjgbui 200 23 of of IN cord-289926-y1rjgbui 200 24 the the DT cord-289926-y1rjgbui 200 25 HIV HIV NNP cord-289926-y1rjgbui 200 26 tat tat NNP cord-289926-y1rjgbui 200 27 and and CC cord-289926-y1rjgbui 200 28 rev rev NNP cord-289926-y1rjgbui 200 29 genes gene NNS cord-289926-y1rjgbui 200 30 , , , cord-289926-y1rjgbui 200 31 bacterial bacterial JJ cord-289926-y1rjgbui 200 32 antiterminators antiterminator NNS cord-289926-y1rjgbui 200 33 and and CC cord-289926-y1rjgbui 200 34 coat coat NN cord-289926-y1rjgbui 200 35 proteins protein NNS cord-289926-y1rjgbui 200 36 from from IN cord-289926-y1rjgbui 200 37 the the DT cord-289926-y1rjgbui 200 38 RNA RNA NNP cord-289926-y1rjgbui 200 39 viruses virus NNS cord-289926-y1rjgbui 200 40 [ [ -LRB- cord-289926-y1rjgbui 200 41 45 45 CD cord-289926-y1rjgbui 200 42 ] ] -RRB- cord-289926-y1rjgbui 200 43 . . . cord-289926-y1rjgbui 201 1 Short short JJ cord-289926-y1rjgbui 201 2 arginine arginine NN cord-289926-y1rjgbui 201 3 - - HYPH cord-289926-y1rjgbui 201 4 rich rich JJ cord-289926-y1rjgbui 201 5 stretches stretch NNS cord-289926-y1rjgbui 201 6 tend tend VBP cord-289926-y1rjgbui 201 7 to to TO cord-289926-y1rjgbui 201 8 form form VB cord-289926-y1rjgbui 201 9 ␣ ␣ CD cord-289926-y1rjgbui 201 10 -helical -helical JJ cord-289926-y1rjgbui 201 11 structures structure NNS cord-289926-y1rjgbui 201 12 , , , cord-289926-y1rjgbui 201 13 which which WDT cord-289926-y1rjgbui 201 14 can can MD cord-289926-y1rjgbui 201 15 bind bind VB cord-289926-y1rjgbui 201 16 in in IN cord-289926-y1rjgbui 201 17 the the DT cord-289926-y1rjgbui 201 18 wide wide JJ cord-289926-y1rjgbui 201 19 groove groove NN cord-289926-y1rjgbui 201 20 of of IN cord-289926-y1rjgbui 201 21 RNA RNA NNP cord-289926-y1rjgbui 201 22 close close RB cord-289926-y1rjgbui 201 23 to to IN cord-289926-y1rjgbui 201 24 loops loop NNS cord-289926-y1rjgbui 201 25 or or CC cord-289926-y1rjgbui 201 26 large large JJ cord-289926-y1rjgbui 201 27 bulges bulge NNS cord-289926-y1rjgbui 201 28 . . . cord-289926-y1rjgbui 202 1 Only only RB cord-289926-y1rjgbui 202 2 one one CD cord-289926-y1rjgbui 202 3 ARM arm NN cord-289926-y1rjgbui 202 4 is be VBZ cord-289926-y1rjgbui 202 5 usually usually RB cord-289926-y1rjgbui 202 6 necessary necessary JJ cord-289926-y1rjgbui 202 7 for for IN cord-289926-y1rjgbui 202 8 binding bind VBG cord-289926-y1rjgbui 202 9 ; ; : cord-289926-y1rjgbui 202 10 an an DT cord-289926-y1rjgbui 202 11 arginine arginine NN cord-289926-y1rjgbui 202 12 - - HYPH cord-289926-y1rjgbui 202 13 rich rich JJ cord-289926-y1rjgbui 202 14 peptide peptide NN cord-289926-y1rjgbui 202 15 as as RB cord-289926-y1rjgbui 202 16 short short JJ cord-289926-y1rjgbui 202 17 as as IN cord-289926-y1rjgbui 202 18 17 17 CD cord-289926-y1rjgbui 202 19 residues residue NNS cord-289926-y1rjgbui 202 20 was be VBD cord-289926-y1rjgbui 202 21 shown show VBN cord-289926-y1rjgbui 202 22 to to TO cord-289926-y1rjgbui 202 23 bind bind VB cord-289926-y1rjgbui 202 24 specifically specifically RB cord-289926-y1rjgbui 202 25 to to IN cord-289926-y1rjgbui 202 26 RNA RNA NNP cord-289926-y1rjgbui 202 27 [ [ -LRB- cord-289926-y1rjgbui 202 28 44 44 CD cord-289926-y1rjgbui 202 29 , , , cord-289926-y1rjgbui 202 30 45 45 CD cord-289926-y1rjgbui 202 31 ] ] -RRB- cord-289926-y1rjgbui 202 32 . . . cord-289926-y1rjgbui 203 1 HDAg HDAg NNP cord-289926-y1rjgbui 203 2 is be VBZ cord-289926-y1rjgbui 203 3 unique unique JJ cord-289926-y1rjgbui 203 4 in in IN cord-289926-y1rjgbui 203 5 that that IN cord-289926-y1rjgbui 203 6 it -PRON- PRP cord-289926-y1rjgbui 203 7 requires require VBZ cord-289926-y1rjgbui 203 8 two two CD cord-289926-y1rjgbui 203 9 ARMs arm NNS cord-289926-y1rjgbui 203 10 instead instead RB cord-289926-y1rjgbui 203 11 of of IN cord-289926-y1rjgbui 203 12 one one CD cord-289926-y1rjgbui 203 13 ; ; : cord-289926-y1rjgbui 203 14 moreover moreover RB cord-289926-y1rjgbui 203 15 , , , cord-289926-y1rjgbui 203 16 the the DT cord-289926-y1rjgbui 203 17 spacer spacer NN cord-289926-y1rjgbui 203 18 between between IN cord-289926-y1rjgbui 203 19 the the DT cord-289926-y1rjgbui 203 20 ARMs arm NNS cord-289926-y1rjgbui 203 21 ( ( -LRB- cord-289926-y1rjgbui 203 22 leucine leucine NNP cord-289926-y1rjgbui 203 23 zipper zipper NN cord-289926-y1rjgbui 203 24 ) ) -RRB- cord-289926-y1rjgbui 203 25 is be VBZ cord-289926-y1rjgbui 203 26 essential essential JJ cord-289926-y1rjgbui 203 27 as as RB cord-289926-y1rjgbui 203 28 well well RB cord-289926-y1rjgbui 203 29 [ [ -LRB- cord-289926-y1rjgbui 203 30 30 30 CD cord-289926-y1rjgbui 203 31 , , , cord-289926-y1rjgbui 203 32 32 32 CD cord-289926-y1rjgbui 203 33 ] ] -RRB- cord-289926-y1rjgbui 203 34 . . . cord-289926-y1rjgbui 204 1 We -PRON- PRP cord-289926-y1rjgbui 204 2 therefore therefore RB cord-289926-y1rjgbui 204 3 think think VBP cord-289926-y1rjgbui 204 4 that that IN cord-289926-y1rjgbui 204 5 each each DT cord-289926-y1rjgbui 204 6 ARM arm NN cord-289926-y1rjgbui 204 7 constitutes constitute VBZ cord-289926-y1rjgbui 204 8 only only RB cord-289926-y1rjgbui 204 9 a a DT cord-289926-y1rjgbui 204 10 part part NN cord-289926-y1rjgbui 204 11 of of IN cord-289926-y1rjgbui 204 12 the the DT cord-289926-y1rjgbui 204 13 RNA RNA NNP cord-289926-y1rjgbui 204 14 - - HYPH cord-289926-y1rjgbui 204 15 binding bind VBG cord-289926-y1rjgbui 204 16 motif motif NN cord-289926-y1rjgbui 204 17 , , , cord-289926-y1rjgbui 204 18 the the DT cord-289926-y1rjgbui 204 19 entire entire JJ cord-289926-y1rjgbui 204 20 motif motif NN cord-289926-y1rjgbui 204 21 being be VBG cord-289926-y1rjgbui 204 22 defined define VBN cord-289926-y1rjgbui 204 23 by by IN cord-289926-y1rjgbui 204 24 its -PRON- PRP$ cord-289926-y1rjgbui 204 25 alignment alignment NN cord-289926-y1rjgbui 204 26 with with IN cord-289926-y1rjgbui 204 27 the the DT cord-289926-y1rjgbui 204 28 HMG HMG NNP cord-289926-y1rjgbui 204 29 box box NN cord-289926-y1rjgbui 204 30 . . . cord-289926-y1rjgbui 205 1 It -PRON- PRP cord-289926-y1rjgbui 205 2 is be VBZ cord-289926-y1rjgbui 205 3 not not RB cord-289926-y1rjgbui 205 4 clear clear JJ cord-289926-y1rjgbui 205 5 whether whether IN cord-289926-y1rjgbui 205 6 the the DT cord-289926-y1rjgbui 205 7 ARM arm NN cord-289926-y1rjgbui 205 8 regions region NNS cord-289926-y1rjgbui 205 9 within within IN cord-289926-y1rjgbui 205 10 the the DT cord-289926-y1rjgbui 205 11 RNA RNA NNP cord-289926-y1rjgbui 205 12 - - HYPH cord-289926-y1rjgbui 205 13 binding bind VBG cord-289926-y1rjgbui 205 14 domain domain NN cord-289926-y1rjgbui 205 15 of of IN cord-289926-y1rjgbui 205 16 HDAg HDAg NNS cord-289926-y1rjgbui 205 17 are be VBP cord-289926-y1rjgbui 205 18 evolutionarily evolutionarily RB cord-289926-y1rjgbui 205 19 related related JJ cord-289926-y1rjgbui 205 20 to to IN cord-289926-y1rjgbui 205 21 ' ' `` cord-289926-y1rjgbui 205 22 classic classic JJ cord-289926-y1rjgbui 205 23 ' ' '' cord-289926-y1rjgbui 205 24 ARMs arm NNS cord-289926-y1rjgbui 205 25 or or CC cord-289926-y1rjgbui 205 26 whether whether IN cord-289926-y1rjgbui 205 27 the the DT cord-289926-y1rjgbui 205 28 sequence sequence NN cord-289926-y1rjgbui 205 29 similarity similarity NN cord-289926-y1rjgbui 205 30 is be VBZ cord-289926-y1rjgbui 205 31 a a DT cord-289926-y1rjgbui 205 32 consequence consequence NN cord-289926-y1rjgbui 205 33 of of IN cord-289926-y1rjgbui 205 34 the the DT cord-289926-y1rjgbui 205 35 functional functional JJ cord-289926-y1rjgbui 205 36 and and CC cord-289926-y1rjgbui 205 37 structural structural JJ cord-289926-y1rjgbui 205 38 constrains constrain NNS cord-289926-y1rjgbui 205 39 imposed impose VBN cord-289926-y1rjgbui 205 40 on on IN cord-289926-y1rjgbui 205 41 the the DT cord-289926-y1rjgbui 205 42 RNA RNA NNP cord-289926-y1rjgbui 205 43 / / SYM cord-289926-y1rjgbui 205 44 DNA dna NN cord-289926-y1rjgbui 205 45 - - HYPH cord-289926-y1rjgbui 205 46 binding bind VBG cord-289926-y1rjgbui 205 47 domain domain NN cord-289926-y1rjgbui 205 48 . . . cord-289926-y1rjgbui 206 1 Alignments alignment NNS cord-289926-y1rjgbui 206 2 of of IN cord-289926-y1rjgbui 206 3 HDAg HDAg NNS cord-289926-y1rjgbui 206 4 and and CC cord-289926-y1rjgbui 206 5 ARM arm NN cord-289926-y1rjgbui 206 6 - - HYPH cord-289926-y1rjgbui 206 7 containing contain VBG cord-289926-y1rjgbui 206 8 sequences sequence NNS cord-289926-y1rjgbui 206 9 such such JJ cord-289926-y1rjgbui 206 10 as as IN cord-289926-y1rjgbui 206 11 rev rev NNP cord-289926-y1rjgbui 206 12 and and CC cord-289926-y1rjgbui 206 13 tat tat NNP cord-289926-y1rjgbui 206 14 show show VBP cord-289926-y1rjgbui 206 15 moderately moderately RB cord-289926-y1rjgbui 206 16 high high JJ cord-289926-y1rjgbui 206 17 levels level NNS cord-289926-y1rjgbui 206 18 of of IN cord-289926-y1rjgbui 206 19 similarity similarity NN cord-289926-y1rjgbui 206 20 , , , cord-289926-y1rjgbui 206 21 but but CC cord-289926-y1rjgbui 206 22 it -PRON- PRP cord-289926-y1rjgbui 206 23 is be VBZ cord-289926-y1rjgbui 206 24 interspersed intersperse VBN cord-289926-y1rjgbui 206 25 across across IN cord-289926-y1rjgbui 206 26 the the DT cord-289926-y1rjgbui 206 27 entire entire JJ cord-289926-y1rjgbui 206 28 sequence sequence NN cord-289926-y1rjgbui 206 29 and and CC cord-289926-y1rjgbui 206 30 no no DT cord-289926-y1rjgbui 206 31 continuous continuous JJ cord-289926-y1rjgbui 206 32 stretches stretch NNS cord-289926-y1rjgbui 206 33 of of IN cord-289926-y1rjgbui 206 34 similarity similarity NN cord-289926-y1rjgbui 206 35 were be VBD cord-289926-y1rjgbui 206 36 found find VBN cord-289926-y1rjgbui 206 37 with with IN cord-289926-y1rjgbui 206 38 the the DT cord-289926-y1rjgbui 206 39 ARM arm NN cord-289926-y1rjgbui 206 40 domains domain NNS cord-289926-y1rjgbui 206 41 of of IN cord-289926-y1rjgbui 206 42 HDAg HDAg NNS cord-289926-y1rjgbui 206 43 . . . cord-289926-y1rjgbui 207 1 The the DT cord-289926-y1rjgbui 207 2 most most RBS cord-289926-y1rjgbui 207 3 extended extended JJ cord-289926-y1rjgbui 207 4 similarity similarity NN cord-289926-y1rjgbui 207 5 found find VBN cord-289926-y1rjgbui 207 6 between between IN cord-289926-y1rjgbui 207 7 the the DT cord-289926-y1rjgbui 207 8 HIV HIV NNP cord-289926-y1rjgbui 207 9 rev rev NNP cord-289926-y1rjgbui 207 10 gene gene NN cord-289926-y1rjgbui 207 11 and and CC cord-289926-y1rjgbui 207 12 the the DT cord-289926-y1rjgbui 207 13 HDAg hdag NN cord-289926-y1rjgbui 207 14 is be VBZ cord-289926-y1rjgbui 207 15 outside outside RB cord-289926-y1rjgbui 207 16 of of IN cord-289926-y1rjgbui 207 17 the the DT cord-289926-y1rjgbui 207 18 RNA RNA NNP cord-289926-y1rjgbui 207 19 binding binding NN cord-289926-y1rjgbui 207 20 domain domain NN cord-289926-y1rjgbui 207 21 of of IN cord-289926-y1rjgbui 207 22 HDAg hdag NN cord-289926-y1rjgbui 207 23 ( ( -LRB- cord-289926-y1rjgbui 207 24 Fig Fig NNP cord-289926-y1rjgbui 207 25 . . . cord-289926-y1rjgbui 207 26 2F 2F NNP cord-289926-y1rjgbui 207 27 ) ) -RRB- cord-289926-y1rjgbui 207 28 . . . cord-289926-y1rjgbui 208 1 Homology homology NN cord-289926-y1rjgbui 208 2 of of IN cord-289926-y1rjgbui 208 3 HDAg HDAg NNS cord-289926-y1rjgbui 208 4 and and CC cord-289926-y1rjgbui 208 5 the the DT cord-289926-y1rjgbui 208 6 DNA dna NN cord-289926-y1rjgbui 208 7 - - HYPH cord-289926-y1rjgbui 208 8 binding bind VBG cord-289926-y1rjgbui 208 9 domain domain NN cord-289926-y1rjgbui 208 10 of of IN cord-289926-y1rjgbui 208 11 HMG HMG NNP cord-289926-y1rjgbui 208 12 box box NN cord-289926-y1rjgbui 208 13 may may MD cord-289926-y1rjgbui 208 14 give give VB cord-289926-y1rjgbui 208 15 insight insight NN cord-289926-y1rjgbui 208 16 into into IN cord-289926-y1rjgbui 208 17 the the DT cord-289926-y1rjgbui 208 18 mechanism mechanism NN cord-289926-y1rjgbui 208 19 of of IN cord-289926-y1rjgbui 208 20 neoplastic neoplastic JJ cord-289926-y1rjgbui 208 21 transformation transformation NN cord-289926-y1rjgbui 208 22 and and CC cord-289926-y1rjgbui 208 23 progression progression NN cord-289926-y1rjgbui 208 24 toward toward IN cord-289926-y1rjgbui 208 25 cirrhosis cirrhosis NN cord-289926-y1rjgbui 208 26 frequently frequently RB cord-289926-y1rjgbui 208 27 observed observe VBD cord-289926-y1rjgbui 208 28 in in IN cord-289926-y1rjgbui 208 29 chronic chronic JJ cord-289926-y1rjgbui 208 30 hepatitis hepatitis NN cord-289926-y1rjgbui 208 31 infection infection NN cord-289926-y1rjgbui 208 32 [ [ -LRB- cord-289926-y1rjgbui 208 33 18 18 CD cord-289926-y1rjgbui 208 34 ] ] -RRB- cord-289926-y1rjgbui 208 35 . . . cord-289926-y1rjgbui 209 1 It -PRON- PRP cord-289926-y1rjgbui 209 2 is be VBZ cord-289926-y1rjgbui 209 3 possible possible JJ cord-289926-y1rjgbui 209 4 that that IN cord-289926-y1rjgbui 209 5 the the DT cord-289926-y1rjgbui 209 6 RNA RNA NNP cord-289926-y1rjgbui 209 7 - - HYPH cord-289926-y1rjgbui 209 8 binding bind VBG cord-289926-y1rjgbui 209 9 domain domain NN cord-289926-y1rjgbui 209 10 of of IN cord-289926-y1rjgbui 209 11 HDAg hdag NN cord-289926-y1rjgbui 209 12 has have VBZ cord-289926-y1rjgbui 209 13 retained retain VBN cord-289926-y1rjgbui 209 14 some some DT cord-289926-y1rjgbui 209 15 of of IN cord-289926-y1rjgbui 209 16 the the DT cord-289926-y1rjgbui 209 17 DNA dna NN cord-289926-y1rjgbui 209 18 - - HYPH cord-289926-y1rjgbui 209 19 binding bind VBG cord-289926-y1rjgbui 209 20 capability capability NN cord-289926-y1rjgbui 209 21 of of IN cord-289926-y1rjgbui 209 22 its -PRON- PRP$ cord-289926-y1rjgbui 209 23 ancestral ancestral JJ cord-289926-y1rjgbui 209 24 HMG HMG NNP cord-289926-y1rjgbui 209 25 box box NN cord-289926-y1rjgbui 209 26 and and CC cord-289926-y1rjgbui 209 27 thus thus RB cord-289926-y1rjgbui 209 28 could could MD cord-289926-y1rjgbui 209 29 activate activate VB cord-289926-y1rjgbui 209 30 cellular cellular JJ cord-289926-y1rjgbui 209 31 proto proto JJ cord-289926-y1rjgbui 209 32 - - HYPH cord-289926-y1rjgbui 209 33 oncogenes oncogene NNS cord-289926-y1rjgbui 209 34 . . . cord-289926-y1rjgbui 210 1 It -PRON- PRP cord-289926-y1rjgbui 210 2 has have VBZ cord-289926-y1rjgbui 210 3 been be VBN cord-289926-y1rjgbui 210 4 shown show VBN cord-289926-y1rjgbui 210 5 that that IN cord-289926-y1rjgbui 210 6 the the DT cord-289926-y1rjgbui 210 7 HMG HMG NNP cord-289926-y1rjgbui 210 8 box box NN cord-289926-y1rjgbui 210 9 of of IN cord-289926-y1rjgbui 210 10 the the DT cord-289926-y1rjgbui 210 11 SRY SRY NNP cord-289926-y1rjgbui 210 12 protein protein NN cord-289926-y1rjgbui 210 13 is be VBZ cord-289926-y1rjgbui 210 14 involved involve VBN cord-289926-y1rjgbui 210 15 in in IN cord-289926-y1rjgbui 210 16 specific specific JJ cord-289926-y1rjgbui 210 17 binding binding NN cord-289926-y1rjgbui 210 18 and and CC cord-289926-y1rjgbui 210 19 regulation regulation NN cord-289926-y1rjgbui 210 20 of of IN cord-289926-y1rjgbui 210 21 the the DT cord-289926-y1rjgbui 210 22 expression expression NN cord-289926-y1rjgbui 210 23 of of IN cord-289926-y1rjgbui 210 24 the the DT cord-289926-y1rjgbui 210 25 cellular cellular JJ cord-289926-y1rjgbui 210 26 proto proto JJ cord-289926-y1rjgbui 210 27 - - HYPH cord-289926-y1rjgbui 210 28 oncogene oncogene NN cord-289926-y1rjgbui 210 29 c c NN cord-289926-y1rjgbui 210 30 - - HYPH cord-289926-y1rjgbui 210 31 fos fos NNP cord-289926-y1rjgbui 210 32 -FRA1 -FRA1 NNP cord-289926-y1rjgbui 210 33 [ [ -LRB- cord-289926-y1rjgbui 210 34 10 10 CD cord-289926-y1rjgbui 210 35 ] ] -RRB- cord-289926-y1rjgbui 210 36 . . . cord-289926-y1rjgbui 211 1 The the DT cord-289926-y1rjgbui 211 2 RNA RNA NNP cord-289926-y1rjgbui 211 3 binding binding NN cord-289926-y1rjgbui 211 4 domain domain NN cord-289926-y1rjgbui 211 5 of of IN cord-289926-y1rjgbui 211 6 HDAg HDAg NNS cord-289926-y1rjgbui 211 7 may may MD cord-289926-y1rjgbui 211 8 be be VB cord-289926-y1rjgbui 211 9 capable capable JJ cord-289926-y1rjgbui 211 10 of of IN cord-289926-y1rjgbui 211 11 similar similar JJ cord-289926-y1rjgbui 211 12 binding binding NN cord-289926-y1rjgbui 211 13 . . . cord-289926-y1rjgbui 212 1 While while IN cord-289926-y1rjgbui 212 2 the the DT cord-289926-y1rjgbui 212 3 specificity specificity NN cord-289926-y1rjgbui 212 4 of of IN cord-289926-y1rjgbui 212 5 such such JJ cord-289926-y1rjgbui 212 6 DNA dna NN cord-289926-y1rjgbui 212 7 binding binding NN cord-289926-y1rjgbui 212 8 by by IN cord-289926-y1rjgbui 212 9 HDAg HDAg NNS cord-289926-y1rjgbui 212 10 is be VBZ cord-289926-y1rjgbui 212 11 likely likely JJ cord-289926-y1rjgbui 212 12 to to TO cord-289926-y1rjgbui 212 13 be be VB cord-289926-y1rjgbui 212 14 lower low JJR cord-289926-y1rjgbui 212 15 than than IN cord-289926-y1rjgbui 212 16 that that DT cord-289926-y1rjgbui 212 17 of of IN cord-289926-y1rjgbui 212 18 a a DT cord-289926-y1rjgbui 212 19 true true JJ cord-289926-y1rjgbui 212 20 transcription transcription NN cord-289926-y1rjgbui 212 21 factor factor NN cord-289926-y1rjgbui 212 22 , , , cord-289926-y1rjgbui 212 23 the the DT cord-289926-y1rjgbui 212 24 sheer sheer JJ cord-289926-y1rjgbui 212 25 abundance abundance NN cord-289926-y1rjgbui 212 26 and and CC cord-289926-y1rjgbui 212 27 persistence persistence NN cord-289926-y1rjgbui 212 28 of of IN cord-289926-y1rjgbui 212 29 the the DT cord-289926-y1rjgbui 212 30 antigen antigen NN cord-289926-y1rjgbui 212 31 during during IN cord-289926-y1rjgbui 212 32 chronic chronic JJ cord-289926-y1rjgbui 212 33 hepatitis hepatitis NN cord-289926-y1rjgbui 212 34 infection infection NN cord-289926-y1rjgbui 212 35 , , , cord-289926-y1rjgbui 212 36 as as RB cord-289926-y1rjgbui 212 37 well well RB cord-289926-y1rjgbui 212 38 as as IN cord-289926-y1rjgbui 212 39 the the DT cord-289926-y1rjgbui 212 40 evolution evolution NN cord-289926-y1rjgbui 212 41 of of IN cord-289926-y1rjgbui 212 42 the the DT cord-289926-y1rjgbui 212 43 HDV HDV NNP cord-289926-y1rjgbui 212 44 genome genome NN cord-289926-y1rjgbui 212 45 throughout throughout IN cord-289926-y1rjgbui 212 46 the the DT cord-289926-y1rjgbui 212 47 course course NN cord-289926-y1rjgbui 212 48 of of IN cord-289926-y1rjgbui 212 49 infection infection NN cord-289926-y1rjgbui 212 50 [ [ -LRB- cord-289926-y1rjgbui 212 51 30 30 CD cord-289926-y1rjgbui 212 52 , , , cord-289926-y1rjgbui 212 53 32 32 CD cord-289926-y1rjgbui 212 54 ] ] -RRB- cord-289926-y1rjgbui 212 55 might may MD cord-289926-y1rjgbui 212 56 be be VB cord-289926-y1rjgbui 212 57 sufficient sufficient JJ cord-289926-y1rjgbui 212 58 to to TO cord-289926-y1rjgbui 212 59 activate activate VB cord-289926-y1rjgbui 212 60 a a DT cord-289926-y1rjgbui 212 61 cellular cellular JJ cord-289926-y1rjgbui 212 62 proto proto JJ cord-289926-y1rjgbui 212 63 - - HYPH cord-289926-y1rjgbui 212 64 oncogene oncogene NN cord-289926-y1rjgbui 212 65 . . . cord-289926-y1rjgbui 213 1 In in IN cord-289926-y1rjgbui 213 2 fact fact NN cord-289926-y1rjgbui 213 3 , , , cord-289926-y1rjgbui 213 4 the the DT cord-289926-y1rjgbui 213 5 expression expression NN cord-289926-y1rjgbui 213 6 of of IN cord-289926-y1rjgbui 213 7 the the DT cord-289926-y1rjgbui 213 8 proto proto JJ cord-289926-y1rjgbui 213 9 - - HYPH cord-289926-y1rjgbui 213 10 oncogene oncogene NN cord-289926-y1rjgbui 213 11 c c NN cord-289926-y1rjgbui 213 12 - - HYPH cord-289926-y1rjgbui 213 13 myc myc NNP cord-289926-y1rjgbui 213 14 is be VBZ cord-289926-y1rjgbui 213 15 a a DT cord-289926-y1rjgbui 213 16 hallmark hallmark NN cord-289926-y1rjgbui 213 17 of of IN cord-289926-y1rjgbui 213 18 chronic chronic JJ cord-289926-y1rjgbui 213 19 HDV HDV NNP cord-289926-y1rjgbui 213 20 infection infection NN cord-289926-y1rjgbui 213 21 ; ; : cord-289926-y1rjgbui 213 22 c c LS cord-289926-y1rjgbui 213 23 - - HYPH cord-289926-y1rjgbui 213 24 myc myc NNP cord-289926-y1rjgbui 213 25 protein protein NN cord-289926-y1rjgbui 213 26 is be VBZ cord-289926-y1rjgbui 213 27 observed observe VBN cord-289926-y1rjgbui 213 28 only only RB cord-289926-y1rjgbui 213 29 in in IN cord-289926-y1rjgbui 213 30 cells cell NNS cord-289926-y1rjgbui 213 31 that that WDT cord-289926-y1rjgbui 213 32 contain contain VBP cord-289926-y1rjgbui 213 33 HDAg HDAg NNS cord-289926-y1rjgbui 213 34 [ [ -LRB- cord-289926-y1rjgbui 213 35 46 46 CD cord-289926-y1rjgbui 213 36 ] ] -RRB- cord-289926-y1rjgbui 213 37 . . . cord-289926-y1rjgbui 214 1 Binding bind VBG cord-289926-y1rjgbui 214 2 of of IN cord-289926-y1rjgbui 214 3 HDAg HDAg NNS cord-289926-y1rjgbui 214 4 to to IN cord-289926-y1rjgbui 214 5 cellular cellular JJ cord-289926-y1rjgbui 214 6 DNA dna NN cord-289926-y1rjgbui 214 7 has have VBZ cord-289926-y1rjgbui 214 8 not not RB cord-289926-y1rjgbui 214 9 been be VBN cord-289926-y1rjgbui 214 10 explored explore VBN cord-289926-y1rjgbui 214 11 . . . cord-289926-y1rjgbui 215 1 It -PRON- PRP cord-289926-y1rjgbui 215 2 would would MD cord-289926-y1rjgbui 215 3 be be VB cord-289926-y1rjgbui 215 4 interesting interesting JJ cord-289926-y1rjgbui 215 5 to to TO cord-289926-y1rjgbui 215 6 test test VB cord-289926-y1rjgbui 215 7 for for IN cord-289926-y1rjgbui 215 8 specific specific JJ cord-289926-y1rjgbui 215 9 binding binding NN cord-289926-y1rjgbui 215 10 of of IN cord-289926-y1rjgbui 215 11 the the DT cord-289926-y1rjgbui 215 12 RNA RNA NNP cord-289926-y1rjgbui 215 13 - - HYPH cord-289926-y1rjgbui 215 14 binding bind VBG cord-289926-y1rjgbui 215 15 domain domain NN cord-289926-y1rjgbui 215 16 of of IN cord-289926-y1rjgbui 215 17 HDAg hdag NN cord-289926-y1rjgbui 215 18 to to IN cord-289926-y1rjgbui 215 19 c c NNP cord-289926-y1rjgbui 215 20 - - HYPH cord-289926-y1rjgbui 215 21 myc myc NNP cord-289926-y1rjgbui 215 22 and and CC cord-289926-y1rjgbui 215 23 other other JJ cord-289926-y1rjgbui 215 24 proto proto JJ cord-289926-y1rjgbui 215 25 - - HYPH cord-289926-y1rjgbui 215 26 oncogenes oncogene NNS cord-289926-y1rjgbui 215 27 that that WDT cord-289926-y1rjgbui 215 28 could could MD cord-289926-y1rjgbui 215 29 be be VB cord-289926-y1rjgbui 215 30 involved involve VBN cord-289926-y1rjgbui 215 31 in in IN cord-289926-y1rjgbui 215 32 the the DT cord-289926-y1rjgbui 215 33 onset onset NN cord-289926-y1rjgbui 215 34 of of IN cord-289926-y1rjgbui 215 35 cirrhosis cirrhosis NN cord-289926-y1rjgbui 215 36 observed observe VBN cord-289926-y1rjgbui 215 37 in in IN cord-289926-y1rjgbui 215 38 HDV HDV NNP cord-289926-y1rjgbui 215 39 patients patient NNS cord-289926-y1rjgbui 215 40 . . . cord-289926-y1rjgbui 216 1 Analysis analysis NN cord-289926-y1rjgbui 216 2 of of IN cord-289926-y1rjgbui 216 3 the the DT cord-289926-y1rjgbui 216 4 HDV HDV NNP cord-289926-y1rjgbui 216 5 genome genome NN cord-289926-y1rjgbui 216 6 suggests suggest VBZ cord-289926-y1rjgbui 216 7 that that IN cord-289926-y1rjgbui 216 8 a a DT cord-289926-y1rjgbui 216 9 large large JJ cord-289926-y1rjgbui 216 10 part part NN cord-289926-y1rjgbui 216 11 of of IN cord-289926-y1rjgbui 216 12 the the DT cord-289926-y1rjgbui 216 13 viral viral JJ cord-289926-y1rjgbui 216 14 genome genome NN cord-289926-y1rjgbui 216 15 , , , cord-289926-y1rjgbui 216 16 including include VBG cord-289926-y1rjgbui 216 17 the the DT cord-289926-y1rjgbui 216 18 sequence sequence NN cord-289926-y1rjgbui 216 19 coding code VBG cord-289926-y1rjgbui 216 20 for for IN cord-289926-y1rjgbui 216 21 HDAg HDAg NNS cord-289926-y1rjgbui 216 22 , , , cord-289926-y1rjgbui 216 23 is be VBZ cord-289926-y1rjgbui 216 24 of of IN cord-289926-y1rjgbui 216 25 cellular cellular JJ cord-289926-y1rjgbui 216 26 origin origin NN cord-289926-y1rjgbui 216 27 , , , cord-289926-y1rjgbui 216 28 while while IN cord-289926-y1rjgbui 216 29 the the DT cord-289926-y1rjgbui 216 30 remaining remain VBG cord-289926-y1rjgbui 216 31 part part NN cord-289926-y1rjgbui 216 32 resembles resemble VBZ cord-289926-y1rjgbui 216 33 a a DT cord-289926-y1rjgbui 216 34 plant plant NN cord-289926-y1rjgbui 216 35 viroid viroid NN cord-289926-y1rjgbui 216 36 sequence sequence NN cord-289926-y1rjgbui 216 37 [ [ -LRB- cord-289926-y1rjgbui 216 38 17 17 CD cord-289926-y1rjgbui 216 39 , , , cord-289926-y1rjgbui 216 40 30 30 CD cord-289926-y1rjgbui 216 41 ] ] -RRB- cord-289926-y1rjgbui 216 42 . . . cord-289926-y1rjgbui 217 1 The the DT cord-289926-y1rjgbui 217 2 ribozyme ribozyme NNS cord-289926-y1rjgbui 217 3 activities activity NNS cord-289926-y1rjgbui 217 4 of of IN cord-289926-y1rjgbui 217 5 HDV HDV NNP cord-289926-y1rjgbui 217 6 , , , cord-289926-y1rjgbui 217 7 such such JJ cord-289926-y1rjgbui 217 8 as as IN cord-289926-y1rjgbui 217 9 self self NN cord-289926-y1rjgbui 217 10 - - HYPH cord-289926-y1rjgbui 217 11 cleavage cleavage NN cord-289926-y1rjgbui 217 12 and and CC cord-289926-y1rjgbui 217 13 self self NN cord-289926-y1rjgbui 217 14 - - HYPH cord-289926-y1rjgbui 217 15 ligation ligation NN cord-289926-y1rjgbui 217 16 , , , cord-289926-y1rjgbui 217 17 further further RB cord-289926-y1rjgbui 217 18 resemble resemble VB cord-289926-y1rjgbui 217 19 the the DT cord-289926-y1rjgbui 217 20 properties property NNS cord-289926-y1rjgbui 217 21 of of IN cord-289926-y1rjgbui 217 22 the the DT cord-289926-y1rjgbui 217 23 viroid viroid NN cord-289926-y1rjgbui 217 24 . . . cord-289926-y1rjgbui 218 1 A a DT cord-289926-y1rjgbui 218 2 possible possible JJ cord-289926-y1rjgbui 218 3 mechanism mechanism NN cord-289926-y1rjgbui 218 4 explaining explain VBG cord-289926-y1rjgbui 218 5 the the DT cord-289926-y1rjgbui 218 6 origin origin NN cord-289926-y1rjgbui 218 7 of of IN cord-289926-y1rjgbui 218 8 HDV HDV NNP cord-289926-y1rjgbui 218 9 -the -the ADD cord-289926-y1rjgbui 218 10 only only RB cord-289926-y1rjgbui 218 11 known know VBN cord-289926-y1rjgbui 218 12 animal animal NN cord-289926-y1rjgbui 218 13 virus virus NN cord-289926-y1rjgbui 218 14 with with IN cord-289926-y1rjgbui 218 15 a a DT cord-289926-y1rjgbui 218 16 circular circular JJ cord-289926-y1rjgbui 218 17 RNA RNA NNP cord-289926-y1rjgbui 218 18 genome genome NN cord-289926-y1rjgbui 218 19 -involves -involve VBZ cord-289926-y1rjgbui 218 20 the the DT cord-289926-y1rjgbui 218 21 capture capture NN cord-289926-y1rjgbui 218 22 of of IN cord-289926-y1rjgbui 218 23 a a DT cord-289926-y1rjgbui 218 24 cellular cellular JJ cord-289926-y1rjgbui 218 25 transcript transcript NN cord-289926-y1rjgbui 218 26 by by IN cord-289926-y1rjgbui 218 27 a a DT cord-289926-y1rjgbui 218 28 viroid viroid NN cord-289926-y1rjgbui 218 29 . . . cord-289926-y1rjgbui 219 1 The the DT cord-289926-y1rjgbui 219 2 elegant elegant JJ cord-289926-y1rjgbui 219 3 capture capture NN cord-289926-y1rjgbui 219 4 mechanism mechanism NN cord-289926-y1rjgbui 219 5 proposed propose VBN cord-289926-y1rjgbui 219 6 by by IN cord-289926-y1rjgbui 219 7 Brazas Brazas NNP cord-289926-y1rjgbui 219 8 and and CC cord-289926-y1rjgbui 219 9 Ganem Ganem NNP cord-289926-y1rjgbui 219 10 [ [ -LRB- cord-289926-y1rjgbui 219 11 5 5 CD cord-289926-y1rjgbui 219 12 ] ] -RRB- cord-289926-y1rjgbui 219 13 involves involve VBZ cord-289926-y1rjgbui 219 14 the the DT cord-289926-y1rjgbui 219 15 fusion fusion NN cord-289926-y1rjgbui 219 16 of of IN cord-289926-y1rjgbui 219 17 the the DT cord-289926-y1rjgbui 219 18 cellular cellular JJ cord-289926-y1rjgbui 219 19 and and CC cord-289926-y1rjgbui 219 20 viral viral JJ cord-289926-y1rjgbui 219 21 transcript transcript NN cord-289926-y1rjgbui 219 22 , , , cord-289926-y1rjgbui 219 23 and and CC cord-289926-y1rjgbui 219 24 duplication duplication NN cord-289926-y1rjgbui 219 25 of of IN cord-289926-y1rjgbui 219 26 the the DT cord-289926-y1rjgbui 219 27 cellular cellular JJ cord-289926-y1rjgbui 219 28 transcript transcript NN cord-289926-y1rjgbui 219 29 during during IN cord-289926-y1rjgbui 219 30 the the DT cord-289926-y1rjgbui 219 31 synthesis synthesis NN cord-289926-y1rjgbui 219 32 of of IN cord-289926-y1rjgbui 219 33 the the DT cord-289926-y1rjgbui 219 34 antisense antisense NN cord-289926-y1rjgbui 219 35 strand strand NN cord-289926-y1rjgbui 219 36 , , , cord-289926-y1rjgbui 219 37 followed follow VBN cord-289926-y1rjgbui 219 38 by by IN cord-289926-y1rjgbui 219 39 the the DT cord-289926-y1rjgbui 219 40 recircularization recircularization NN cord-289926-y1rjgbui 219 41 of of IN cord-289926-y1rjgbui 219 42 the the DT cord-289926-y1rjgbui 219 43 entire entire JJ cord-289926-y1rjgbui 219 44 transcript transcript NN cord-289926-y1rjgbui 219 45 ( ( -LRB- cord-289926-y1rjgbui 219 46 Fig Fig NNP cord-289926-y1rjgbui 219 47 . . NNP cord-289926-y1rjgbui 219 48 5 5 CD cord-289926-y1rjgbui 219 49 ) ) -RRB- cord-289926-y1rjgbui 219 50 . . . cord-289926-y1rjgbui 220 1 The the DT cord-289926-y1rjgbui 220 2 size size NN cord-289926-y1rjgbui 220 3 of of IN cord-289926-y1rjgbui 220 4 the the DT cord-289926-y1rjgbui 220 5 SRY SRY NNP cord-289926-y1rjgbui 220 6 protein protein NN cord-289926-y1rjgbui 220 7 matches match VBZ cord-289926-y1rjgbui 220 8 the the DT cord-289926-y1rjgbui 220 9 HDV HDV NNP cord-289926-y1rjgbui 220 10 size size NN cord-289926-y1rjgbui 220 11 requirements requirement NNS cord-289926-y1rjgbui 220 12 : : : cord-289926-y1rjgbui 220 13 SRY SRY NNP cord-289926-y1rjgbui 220 14 is be VBZ cord-289926-y1rjgbui 220 15 204 204 CD cord-289926-y1rjgbui 220 16 residues residue NNS cord-289926-y1rjgbui 220 17 long long RB cord-289926-y1rjgbui 220 18 ; ; : cord-289926-y1rjgbui 220 19 duplication duplication NN cord-289926-y1rjgbui 220 20 of of IN cord-289926-y1rjgbui 220 21 the the DT cord-289926-y1rjgbui 220 22 SRY SRY NNP cord-289926-y1rjgbui 220 23 RNA RNA NNP cord-289926-y1rjgbui 220 24 would would MD cord-289926-y1rjgbui 220 25 result result VB cord-289926-y1rjgbui 220 26 in in IN cord-289926-y1rjgbui 220 27 a a DT cord-289926-y1rjgbui 220 28 cellular cellular JJ cord-289926-y1rjgbui 220 29 part part NN cord-289926-y1rjgbui 220 30 of of IN cord-289926-y1rjgbui 220 31 HDV HDV NNP cord-289926-y1rjgbui 220 32 over over IN cord-289926-y1rjgbui 220 33 1200 1200 CD cord-289926-y1rjgbui 220 34 bases basis NNS cord-289926-y1rjgbui 220 35 long long JJ cord-289926-y1rjgbui 221 1 ( ( -LRB- cord-289926-y1rjgbui 221 2 the the DT cord-289926-y1rjgbui 221 3 exact exact JJ cord-289926-y1rjgbui 221 4 length length NN cord-289926-y1rjgbui 221 5 will will MD cord-289926-y1rjgbui 221 6 depend depend VB cord-289926-y1rjgbui 221 7 on on IN cord-289926-y1rjgbui 221 8 the the DT cord-289926-y1rjgbui 221 9 length length NN cord-289926-y1rjgbui 221 10 of of IN cord-289926-y1rjgbui 221 11 the the DT cord-289926-y1rjgbui 221 12 non non JJ cord-289926-y1rjgbui 221 13 - - JJ cord-289926-y1rjgbui 221 14 coding coding JJ cord-289926-y1rjgbui 221 15 regions region NNS cord-289926-y1rjgbui 221 16 of of IN cord-289926-y1rjgbui 221 17 the the DT cord-289926-y1rjgbui 221 18 SRY SRY NNP cord-289926-y1rjgbui 221 19 transcript transcript NN cord-289926-y1rjgbui 221 20 ) ) -RRB- cord-289926-y1rjgbui 221 21 . . . cord-289926-y1rjgbui 222 1 This this DT cord-289926-y1rjgbui 222 2 agrees agree VBZ cord-289926-y1rjgbui 222 3 with with IN cord-289926-y1rjgbui 222 4 the the DT cord-289926-y1rjgbui 222 5 approximately approximately RB cord-289926-y1rjgbui 222 6 1300 1300 CD cord-289926-y1rjgbui 222 7 bases basis NNS cord-289926-y1rjgbui 222 8 of of IN cord-289926-y1rjgbui 222 9 highly highly RB cord-289926-y1rjgbui 222 10 self self NN cord-289926-y1rjgbui 222 11 - - HYPH cord-289926-y1rjgbui 222 12 complementary complementary JJ cord-289926-y1rjgbui 222 13 RNA RNA NNP cord-289926-y1rjgbui 222 14 of of IN cord-289926-y1rjgbui 222 15 cellular cellular JJ cord-289926-y1rjgbui 222 16 origin origin NN cord-289926-y1rjgbui 222 17 in in IN cord-289926-y1rjgbui 222 18 HDV HDV NNP cord-289926-y1rjgbui 222 19 . . . cord-289926-y1rjgbui 223 1 The the DT cord-289926-y1rjgbui 223 2 replication replication NN cord-289926-y1rjgbui 223 3 of of IN cord-289926-y1rjgbui 223 4 HDV HDV NNP cord-289926-y1rjgbui 223 5 is be VBZ cord-289926-y1rjgbui 223 6 conducted conduct VBN cord-289926-y1rjgbui 223 7 by by IN cord-289926-y1rjgbui 223 8 cellular cellular JJ cord-289926-y1rjgbui 223 9 machinery machinery NN cord-289926-y1rjgbui 223 10 , , , cord-289926-y1rjgbui 223 11 with with IN cord-289926-y1rjgbui 223 12 the the DT cord-289926-y1rjgbui 223 13 addition addition NN cord-289926-y1rjgbui 223 14 of of IN cord-289926-y1rjgbui 223 15 HDAg HDAg NNS cord-289926-y1rjgbui 223 16 . . . cord-289926-y1rjgbui 224 1 HDAg HDAg NNP cord-289926-y1rjgbui 224 2 is be VBZ cord-289926-y1rjgbui 224 3 absolutely absolutely RB cord-289926-y1rjgbui 224 4 required require VBN cord-289926-y1rjgbui 224 5 for for IN cord-289926-y1rjgbui 224 6 in in IN cord-289926-y1rjgbui 224 7 vivo vivo FW cord-289926-y1rjgbui 224 8 HDV HDV NNP cord-289926-y1rjgbui 224 9 replication replication NN cord-289926-y1rjgbui 224 10 [ [ -LRB- cord-289926-y1rjgbui 224 11 32 32 CD cord-289926-y1rjgbui 224 12 ] ] -RRB- cord-289926-y1rjgbui 224 13 and and CC cord-289926-y1rjgbui 224 14 serves serve VBZ cord-289926-y1rjgbui 224 15 as as IN cord-289926-y1rjgbui 224 16 a a DT cord-289926-y1rjgbui 224 17 bridging bridge VBG cord-289926-y1rjgbui 224 18 factor factor NN cord-289926-y1rjgbui 224 19 between between IN cord-289926-y1rjgbui 224 20 the the DT cord-289926-y1rjgbui 224 21 viral viral JJ cord-289926-y1rjgbui 224 22 template template NN cord-289926-y1rjgbui 224 23 and and CC cord-289926-y1rjgbui 224 24 cellular cellular JJ cord-289926-y1rjgbui 224 25 transcriptional transcriptional JJ cord-289926-y1rjgbui 224 26 complex complex NN cord-289926-y1rjgbui 224 27 . . . cord-289926-y1rjgbui 225 1 Coopting coopte VBG cord-289926-y1rjgbui 225 2 a a DT cord-289926-y1rjgbui 225 3 single single JJ cord-289926-y1rjgbui 225 4 component component NN cord-289926-y1rjgbui 225 5 of of IN cord-289926-y1rjgbui 225 6 the the DT cord-289926-y1rjgbui 225 7 cellular cellular JJ cord-289926-y1rjgbui 225 8 Fig Fig NNP cord-289926-y1rjgbui 225 9 . . . cord-289926-y1rjgbui 226 1 5 5 LS cord-289926-y1rjgbui 226 2 . . . cord-289926-y1rjgbui 227 1 Possible possible JJ cord-289926-y1rjgbui 227 2 mechanism mechanism NN cord-289926-y1rjgbui 227 3 of of IN cord-289926-y1rjgbui 227 4 HDV HDV NNP cord-289926-y1rjgbui 227 5 formation formation NN cord-289926-y1rjgbui 227 6 . . . cord-289926-y1rjgbui 228 1 A a DT cord-289926-y1rjgbui 228 2 Viroid viroid JJ cord-289926-y1rjgbui 228 3 sense sense NN cord-289926-y1rjgbui 228 4 strand strand NN cord-289926-y1rjgbui 228 5 joins join VBZ cord-289926-y1rjgbui 228 6 at at IN cord-289926-y1rjgbui 228 7 the the DT cord-289926-y1rjgbui 228 8 3 3 CD cord-289926-y1rjgbui 228 9 -end -end SYM cord-289926-y1rjgbui 228 10 of of IN cord-289926-y1rjgbui 228 11 SRY SRY NNP cord-289926-y1rjgbui 228 12 transcript transcript NN cord-289926-y1rjgbui 228 13 . . . cord-289926-y1rjgbui 229 1 B B NNP cord-289926-y1rjgbui 229 2 Replication replication NN cord-289926-y1rjgbui 229 3 begins begin VBZ cord-289926-y1rjgbui 229 4 at at IN cord-289926-y1rjgbui 229 5 the the DT cord-289926-y1rjgbui 229 6 3 3 CD cord-289926-y1rjgbui 229 7 -end -end : cord-289926-y1rjgbui 229 8 of of IN cord-289926-y1rjgbui 229 9 the the DT cord-289926-y1rjgbui 229 10 viroid viroid NN cord-289926-y1rjgbui 229 11 and and CC cord-289926-y1rjgbui 229 12 proceeds proceed VBZ cord-289926-y1rjgbui 229 13 through through IN cord-289926-y1rjgbui 229 14 SRY SRY NNP cord-289926-y1rjgbui 229 15 , , , cord-289926-y1rjgbui 229 16 synthesizing synthesize VBG cord-289926-y1rjgbui 229 17 an an DT cord-289926-y1rjgbui 229 18 antisense antisense NN cord-289926-y1rjgbui 229 19 of of IN cord-289926-y1rjgbui 229 20 the the DT cord-289926-y1rjgbui 229 21 viroid viroid NNP cord-289926-y1rjgbui 229 22 genome genome NN cord-289926-y1rjgbui 229 23 and and CC cord-289926-y1rjgbui 229 24 of of IN cord-289926-y1rjgbui 229 25 the the DT cord-289926-y1rjgbui 229 26 SRY SRY NNP cord-289926-y1rjgbui 229 27 transcript transcript NN cord-289926-y1rjgbui 229 28 . . . cord-289926-y1rjgbui 230 1 A a DT cord-289926-y1rjgbui 230 2 hairpin hairpin JJ cord-289926-y1rjgbui 230 3 structure structure NN cord-289926-y1rjgbui 230 4 at at IN cord-289926-y1rjgbui 230 5 the the DT cord-289926-y1rjgbui 230 6 5 5 CD cord-289926-y1rjgbui 230 7 -end -end : cord-289926-y1rjgbui 230 8 of of IN cord-289926-y1rjgbui 230 9 SRY SRY NNP cord-289926-y1rjgbui 230 10 template template NN cord-289926-y1rjgbui 230 11 allows allow VBZ cord-289926-y1rjgbui 230 12 transcription transcription NN cord-289926-y1rjgbui 230 13 to to TO cord-289926-y1rjgbui 230 14 continue continue VB cord-289926-y1rjgbui 230 15 synthesizing synthesize VBG cord-289926-y1rjgbui 230 16 a a DT cord-289926-y1rjgbui 230 17 complement complement NN cord-289926-y1rjgbui 230 18 of of IN cord-289926-y1rjgbui 230 19 the the DT cord-289926-y1rjgbui 230 20 SRY SRY NNP cord-289926-y1rjgbui 230 21 - - : cord-289926-y1rjgbui 230 22 that that DT cord-289926-y1rjgbui 230 23 is be VBZ cord-289926-y1rjgbui 230 24 a a DT cord-289926-y1rjgbui 230 25 sense sense NN cord-289926-y1rjgbui 230 26 version version NN cord-289926-y1rjgbui 230 27 of of IN cord-289926-y1rjgbui 230 28 SRY SRY NNP cord-289926-y1rjgbui 230 29 transcript transcript NN cord-289926-y1rjgbui 230 30 . . . cord-289926-y1rjgbui 231 1 The the DT cord-289926-y1rjgbui 231 2 resulting result VBG cord-289926-y1rjgbui 231 3 construct construct NN cord-289926-y1rjgbui 231 4 has have VBZ cord-289926-y1rjgbui 231 5 an an DT cord-289926-y1rjgbui 231 6 antisense antisense JJ cord-289926-y1rjgbui 231 7 strand strand NN cord-289926-y1rjgbui 231 8 of of IN cord-289926-y1rjgbui 231 9 the the DT cord-289926-y1rjgbui 231 10 viroid viroid NN cord-289926-y1rjgbui 231 11 , , , cord-289926-y1rjgbui 231 12 followed follow VBN cord-289926-y1rjgbui 231 13 by by IN cord-289926-y1rjgbui 231 14 the the DT cord-289926-y1rjgbui 231 15 antisense antisense NN cord-289926-y1rjgbui 231 16 copy copy NN cord-289926-y1rjgbui 231 17 of of IN cord-289926-y1rjgbui 231 18 SRY SRY NNP cord-289926-y1rjgbui 231 19 followed follow VBN cord-289926-y1rjgbui 231 20 by by IN cord-289926-y1rjgbui 231 21 the the DT cord-289926-y1rjgbui 231 22 sense sense NN cord-289926-y1rjgbui 231 23 copy copy NN cord-289926-y1rjgbui 231 24 of of IN cord-289926-y1rjgbui 231 25 SRY SRY NNP cord-289926-y1rjgbui 231 26 . . . cord-289926-y1rjgbui 232 1 C C NNP cord-289926-y1rjgbui 232 2 Circularization Circularization NNP cord-289926-y1rjgbui 232 3 of of IN cord-289926-y1rjgbui 232 4 the the DT cord-289926-y1rjgbui 232 5 linear linear JJ cord-289926-y1rjgbui 232 6 transcript transcript NN cord-289926-y1rjgbui 232 7 . . . cord-289926-y1rjgbui 233 1 D D NNP cord-289926-y1rjgbui 233 2 Additional additional JJ cord-289926-y1rjgbui 233 3 round round NN cord-289926-y1rjgbui 233 4 of of IN cord-289926-y1rjgbui 233 5 replication replication NN cord-289926-y1rjgbui 233 6 results result NNS cord-289926-y1rjgbui 233 7 in in IN cord-289926-y1rjgbui 233 8 the the DT cord-289926-y1rjgbui 233 9 reversal reversal NN cord-289926-y1rjgbui 233 10 order order NN cord-289926-y1rjgbui 233 11 of of IN cord-289926-y1rjgbui 233 12 the the DT cord-289926-y1rjgbui 233 13 regions region NNS cord-289926-y1rjgbui 233 14 : : : cord-289926-y1rjgbui 234 1 viroid viroid NNP cord-289926-y1rjgbui 234 2 region region NN cord-289926-y1rjgbui 234 3 ( ( -LRB- cord-289926-y1rjgbui 234 4 sense sense NN cord-289926-y1rjgbui 234 5 ) ) -RRB- cord-289926-y1rjgbui 234 6 is be VBZ cord-289926-y1rjgbui 234 7 followed follow VBN cord-289926-y1rjgbui 234 8 by by IN cord-289926-y1rjgbui 234 9 antisense antisense NN cord-289926-y1rjgbui 234 10 strand strand NN cord-289926-y1rjgbui 234 11 of of IN cord-289926-y1rjgbui 234 12 SRY SRY NNP cord-289926-y1rjgbui 234 13 , , , cord-289926-y1rjgbui 234 14 which which WDT cord-289926-y1rjgbui 234 15 in in IN cord-289926-y1rjgbui 234 16 turn turn NN cord-289926-y1rjgbui 234 17 is be VBZ cord-289926-y1rjgbui 234 18 followed follow VBN cord-289926-y1rjgbui 234 19 by by IN cord-289926-y1rjgbui 234 20 the the DT cord-289926-y1rjgbui 234 21 sense sense NN cord-289926-y1rjgbui 234 22 strand strand NN cord-289926-y1rjgbui 234 23 of of IN cord-289926-y1rjgbui 234 24 SRY SRY NNP cord-289926-y1rjgbui 234 25 . . . cord-289926-y1rjgbui 235 1 E e LS cord-289926-y1rjgbui 235 2 Subsequent subsequent JJ cord-289926-y1rjgbui 235 3 evolution evolution NN cord-289926-y1rjgbui 235 4 of of IN cord-289926-y1rjgbui 235 5 the the DT cord-289926-y1rjgbui 235 6 genome genome NN cord-289926-y1rjgbui 235 7 results result NNS cord-289926-y1rjgbui 235 8 in in IN cord-289926-y1rjgbui 235 9 the the DT cord-289926-y1rjgbui 235 10 organization organization NN cord-289926-y1rjgbui 235 11 of of IN cord-289926-y1rjgbui 235 12 domains domain NNS cord-289926-y1rjgbui 235 13 seen see VBN cord-289926-y1rjgbui 235 14 in in IN cord-289926-y1rjgbui 235 15 the the DT cord-289926-y1rjgbui 235 16 HDV HDV NNP cord-289926-y1rjgbui 235 17 today today NN cord-289926-y1rjgbui 236 1 : : : cord-289926-y1rjgbui 236 2 a a DT cord-289926-y1rjgbui 236 3 viroid viroid JJ cord-289926-y1rjgbui 236 4 region region NN cord-289926-y1rjgbui 236 5 is be VBZ cord-289926-y1rjgbui 236 6 followed follow VBN cord-289926-y1rjgbui 236 7 by by IN cord-289926-y1rjgbui 236 8 an an DT cord-289926-y1rjgbui 236 9 antisense antisense NN cord-289926-y1rjgbui 236 10 of of IN cord-289926-y1rjgbui 236 11 HDV HDV NNP cord-289926-y1rjgbui 236 12 antigen antigen NN cord-289926-y1rjgbui 236 13 followed follow VBN cord-289926-y1rjgbui 236 14 by by IN cord-289926-y1rjgbui 236 15 a a DT cord-289926-y1rjgbui 236 16 non non JJ cord-289926-y1rjgbui 236 17 - - JJ cord-289926-y1rjgbui 236 18 coding coding JJ cord-289926-y1rjgbui 236 19 region region NN cord-289926-y1rjgbui 236 20 which which WDT cord-289926-y1rjgbui 236 21 is be VBZ cord-289926-y1rjgbui 236 22 highly highly RB cord-289926-y1rjgbui 236 23 complementary complementary JJ cord-289926-y1rjgbui 236 24 to to IN cord-289926-y1rjgbui 236 25 the the DT cord-289926-y1rjgbui 236 26 region region NN cord-289926-y1rjgbui 236 27 coding code VBG cord-289926-y1rjgbui 236 28 for for IN cord-289926-y1rjgbui 236 29 the the DT cord-289926-y1rjgbui 236 30 HDV HDV NNP cord-289926-y1rjgbui 236 31 antigen antigen NN cord-289926-y1rjgbui 236 32 transcriptional transcriptional JJ cord-289926-y1rjgbui 236 33 machinery machinery NN cord-289926-y1rjgbui 236 34 and and CC cord-289926-y1rjgbui 236 35 adapting adapt VBG cord-289926-y1rjgbui 236 36 its -PRON- PRP$ cord-289926-y1rjgbui 236 37 specificity specificity NN cord-289926-y1rjgbui 236 38 to to TO cord-289926-y1rjgbui 236 39 prefer prefer VB cord-289926-y1rjgbui 236 40 the the DT cord-289926-y1rjgbui 236 41 viral viral JJ cord-289926-y1rjgbui 236 42 template template NN cord-289926-y1rjgbui 236 43 is be VBZ cord-289926-y1rjgbui 236 44 an an DT cord-289926-y1rjgbui 236 45 elegant elegant JJ cord-289926-y1rjgbui 236 46 way way NN cord-289926-y1rjgbui 236 47 to to TO cord-289926-y1rjgbui 236 48 ensure ensure VB cord-289926-y1rjgbui 236 49 viral viral JJ cord-289926-y1rjgbui 236 50 replication replication NN cord-289926-y1rjgbui 236 51 and and CC cord-289926-y1rjgbui 236 52 survival survival NN cord-289926-y1rjgbui 236 53 . . . cord-289926-y1rjgbui 237 1 It -PRON- PRP cord-289926-y1rjgbui 237 2 is be VBZ cord-289926-y1rjgbui 237 3 notable notable JJ cord-289926-y1rjgbui 237 4 that that IN cord-289926-y1rjgbui 237 5 the the DT cord-289926-y1rjgbui 237 6 tissue tissue NN cord-289926-y1rjgbui 237 7 - - HYPH cord-289926-y1rjgbui 237 8 specificity specificity NN cord-289926-y1rjgbui 237 9 of of IN cord-289926-y1rjgbui 237 10 SRY SRY NNP cord-289926-y1rjgbui 237 11 does do VBZ cord-289926-y1rjgbui 237 12 not not RB cord-289926-y1rjgbui 237 13 match match VB cord-289926-y1rjgbui 237 14 that that DT cord-289926-y1rjgbui 237 15 of of IN cord-289926-y1rjgbui 237 16 HDV HDV NNP cord-289926-y1rjgbui 237 17 : : : cord-289926-y1rjgbui 238 1 SRY SRY NNP cord-289926-y1rjgbui 238 2 is be VBZ cord-289926-y1rjgbui 238 3 expressed express VBN cord-289926-y1rjgbui 238 4 primarily primarily RB cord-289926-y1rjgbui 238 5 in in IN cord-289926-y1rjgbui 238 6 germ germ NN cord-289926-y1rjgbui 238 7 cells cell NNS cord-289926-y1rjgbui 238 8 and and CC cord-289926-y1rjgbui 238 9 in in IN cord-289926-y1rjgbui 238 10 somatic somatic JJ cord-289926-y1rjgbui 238 11 cells cell NNS cord-289926-y1rjgbui 238 12 of of IN cord-289926-y1rjgbui 238 13 the the DT cord-289926-y1rjgbui 238 14 testis testis NN cord-289926-y1rjgbui 238 15 [ [ -LRB- cord-289926-y1rjgbui 238 16 51 51 CD cord-289926-y1rjgbui 238 17 ] ] -RRB- cord-289926-y1rjgbui 238 18 , , , cord-289926-y1rjgbui 238 19 while while IN cord-289926-y1rjgbui 238 20 HDV HDV NNP cord-289926-y1rjgbui 238 21 is be VBZ cord-289926-y1rjgbui 238 22 restricted restrict VBN cord-289926-y1rjgbui 238 23 to to IN cord-289926-y1rjgbui 238 24 liver liver NN cord-289926-y1rjgbui 238 25 tissue tissue NN cord-289926-y1rjgbui 238 26 . . . cord-289926-y1rjgbui 239 1 It -PRON- PRP cord-289926-y1rjgbui 239 2 has have VBZ cord-289926-y1rjgbui 239 3 been be VBN cord-289926-y1rjgbui 239 4 shown show VBN cord-289926-y1rjgbui 239 5 experimentally experimentally RB cord-289926-y1rjgbui 239 6 , , , cord-289926-y1rjgbui 239 7 however however RB cord-289926-y1rjgbui 239 8 , , , cord-289926-y1rjgbui 239 9 that that IN cord-289926-y1rjgbui 239 10 the the DT cord-289926-y1rjgbui 239 11 replication replication NN cord-289926-y1rjgbui 239 12 of of IN cord-289926-y1rjgbui 239 13 the the DT cord-289926-y1rjgbui 239 14 HDV HDV NNP cord-289926-y1rjgbui 239 15 can can MD cord-289926-y1rjgbui 239 16 proceed proceed VB cord-289926-y1rjgbui 239 17 in in IN cord-289926-y1rjgbui 239 18 the the DT cord-289926-y1rjgbui 239 19 skeletal skeletal JJ cord-289926-y1rjgbui 239 20 muscle muscle NN cord-289926-y1rjgbui 239 21 [ [ -LRB- cord-289926-y1rjgbui 239 22 37 37 CD cord-289926-y1rjgbui 239 23 ] ] -RRB- cord-289926-y1rjgbui 239 24 . . . cord-289926-y1rjgbui 240 1 A a DT cord-289926-y1rjgbui 240 2 low low JJ cord-289926-y1rjgbui 240 3 level level NN cord-289926-y1rjgbui 240 4 of of IN cord-289926-y1rjgbui 240 5 SRY SRY NNP cord-289926-y1rjgbui 240 6 could could MD cord-289926-y1rjgbui 240 7 be be VB cord-289926-y1rjgbui 240 8 expressed express VBN cord-289926-y1rjgbui 240 9 in in IN cord-289926-y1rjgbui 240 10 other other JJ cord-289926-y1rjgbui 240 11 tissues tissue NNS cord-289926-y1rjgbui 240 12 , , , cord-289926-y1rjgbui 240 13 including include VBG cord-289926-y1rjgbui 240 14 the the DT cord-289926-y1rjgbui 240 15 liver liver NN cord-289926-y1rjgbui 240 16 , , , cord-289926-y1rjgbui 240 17 allowing allow VBG cord-289926-y1rjgbui 240 18 for for IN cord-289926-y1rjgbui 240 19 transcript transcript NN cord-289926-y1rjgbui 240 20 capture capture NN cord-289926-y1rjgbui 240 21 , , , cord-289926-y1rjgbui 240 22 or or CC cord-289926-y1rjgbui 240 23 alternatively alternatively RB cord-289926-y1rjgbui 240 24 , , , cord-289926-y1rjgbui 240 25 HDV HDV NNP cord-289926-y1rjgbui 240 26 could could MD cord-289926-y1rjgbui 240 27 have have VB cord-289926-y1rjgbui 240 28 evolved evolve VBN cord-289926-y1rjgbui 240 29 from from IN cord-289926-y1rjgbui 240 30 an an DT cord-289926-y1rjgbui 240 31 SRY sry NN cord-289926-y1rjgbui 240 32 - - HYPH cord-289926-y1rjgbui 240 33 related relate VBN cord-289926-y1rjgbui 240 34 gene gene NN cord-289926-y1rjgbui 240 35 specifically specifically RB cord-289926-y1rjgbui 240 36 expressed express VBN cord-289926-y1rjgbui 240 37 in in IN cord-289926-y1rjgbui 240 38 liver liver NN cord-289926-y1rjgbui 240 39 , , , cord-289926-y1rjgbui 240 40 such such JJ cord-289926-y1rjgbui 240 41 as as IN cord-289926-y1rjgbui 240 42 SOX-18 SOX-18 NNP cord-289926-y1rjgbui 240 43 [ [ -LRB- cord-289926-y1rjgbui 240 44 15 15 CD cord-289926-y1rjgbui 240 45 ] ] -RRB- cord-289926-y1rjgbui 240 46 . . . cord-289926-y1rjgbui 241 1 Finally finally RB cord-289926-y1rjgbui 241 2 , , , cord-289926-y1rjgbui 241 3 it -PRON- PRP cord-289926-y1rjgbui 241 4 is be VBZ cord-289926-y1rjgbui 241 5 possible possible JJ cord-289926-y1rjgbui 241 6 that that IN cord-289926-y1rjgbui 241 7 the the DT cord-289926-y1rjgbui 241 8 expression expression NN cord-289926-y1rjgbui 241 9 of of IN cord-289926-y1rjgbui 241 10 original original JJ cord-289926-y1rjgbui 241 11 viroid viroid NN cord-289926-y1rjgbui 241 12 was be VBD cord-289926-y1rjgbui 241 13 not not RB cord-289926-y1rjgbui 241 14 confined confine VBN cord-289926-y1rjgbui 241 15 to to IN cord-289926-y1rjgbui 241 16 liver liver NN cord-289926-y1rjgbui 241 17 cells cell NNS cord-289926-y1rjgbui 241 18 and and CC cord-289926-y1rjgbui 241 19 the the DT cord-289926-y1rjgbui 241 20 initial initial JJ cord-289926-y1rjgbui 241 21 capture capture NN cord-289926-y1rjgbui 241 22 event event NN cord-289926-y1rjgbui 241 23 of of IN cord-289926-y1rjgbui 241 24 cellular cellular JJ cord-289926-y1rjgbui 241 25 RNA RNA NNP cord-289926-y1rjgbui 241 26 could could MD cord-289926-y1rjgbui 241 27 have have VB cord-289926-y1rjgbui 241 28 occurred occur VBN cord-289926-y1rjgbui 241 29 in in IN cord-289926-y1rjgbui 241 30 a a DT cord-289926-y1rjgbui 241 31 stem stem NN cord-289926-y1rjgbui 241 32 or or CC cord-289926-y1rjgbui 241 33 germ germ NN cord-289926-y1rjgbui 241 34 cell cell NN cord-289926-y1rjgbui 241 35 where where WRB cord-289926-y1rjgbui 241 36 SRY SRY NNP cord-289926-y1rjgbui 241 37 is be VBZ cord-289926-y1rjgbui 241 38 abundantly abundantly RB cord-289926-y1rjgbui 241 39 expressed express VBN cord-289926-y1rjgbui 241 40 [ [ -LRB- cord-289926-y1rjgbui 241 41 51 51 CD cord-289926-y1rjgbui 241 42 ] ] -RRB- cord-289926-y1rjgbui 241 43 . . . cord-289926-y1rjgbui 242 1 This this DT cord-289926-y1rjgbui 242 2 would would MD cord-289926-y1rjgbui 242 3 introduce introduce VB cord-289926-y1rjgbui 242 4 HDV HDV NNP cord-289926-y1rjgbui 242 5 into into IN cord-289926-y1rjgbui 242 6 many many JJ cord-289926-y1rjgbui 242 7 cell cell NN cord-289926-y1rjgbui 242 8 types type NNS cord-289926-y1rjgbui 242 9 ; ; : cord-289926-y1rjgbui 242 10 its -PRON- PRP$ cord-289926-y1rjgbui 242 11 eventual eventual JJ cord-289926-y1rjgbui 242 12 dependence dependence NN cord-289926-y1rjgbui 242 13 for for IN cord-289926-y1rjgbui 242 14 replication replication NN cord-289926-y1rjgbui 242 15 on on IN cord-289926-y1rjgbui 242 16 hepatitis hepatitis NN cord-289926-y1rjgbui 242 17 B B NNP cord-289926-y1rjgbui 242 18 virus virus NN cord-289926-y1rjgbui 242 19 would would MD cord-289926-y1rjgbui 242 20 limit limit VB cord-289926-y1rjgbui 242 21 its -PRON- PRP$ cord-289926-y1rjgbui 242 22 range range NN cord-289926-y1rjgbui 242 23 to to IN cord-289926-y1rjgbui 242 24 the the DT cord-289926-y1rjgbui 242 25 liver liver NN cord-289926-y1rjgbui 242 26 cells cell NNS cord-289926-y1rjgbui 242 27 . . . cord-289926-y1rjgbui 243 1 It -PRON- PRP cord-289926-y1rjgbui 243 2 may may MD cord-289926-y1rjgbui 243 3 never never RB cord-289926-y1rjgbui 243 4 be be VB cord-289926-y1rjgbui 243 5 possible possible JJ cord-289926-y1rjgbui 243 6 to to TO cord-289926-y1rjgbui 243 7 conclusively conclusively RB cord-289926-y1rjgbui 243 8 determine determine VB cord-289926-y1rjgbui 243 9 the the DT cord-289926-y1rjgbui 243 10 origin origin NN cord-289926-y1rjgbui 243 11 of of IN cord-289926-y1rjgbui 243 12 HDAg HDAg NNP cord-289926-y1rjgbui 243 13 based base VBN cord-289926-y1rjgbui 243 14 on on IN cord-289926-y1rjgbui 243 15 sequence sequence NN cord-289926-y1rjgbui 243 16 similarity similarity NN cord-289926-y1rjgbui 243 17 alone alone RB cord-289926-y1rjgbui 243 18 , , , cord-289926-y1rjgbui 243 19 since since IN cord-289926-y1rjgbui 243 20 RNA rna NN cord-289926-y1rjgbui 243 21 - - HYPH cord-289926-y1rjgbui 243 22 encoded encode VBN cord-289926-y1rjgbui 243 23 genes gene NNS cord-289926-y1rjgbui 243 24 evolve evolve VBP cord-289926-y1rjgbui 243 25 rapidly rapidly RB cord-289926-y1rjgbui 243 26 . . . cord-289926-y1rjgbui 244 1 However however RB cord-289926-y1rjgbui 244 2 several several JJ cord-289926-y1rjgbui 244 3 arguments argument NNS cord-289926-y1rjgbui 244 4 can can MD cord-289926-y1rjgbui 244 5 be be VB cord-289926-y1rjgbui 244 6 made make VBN cord-289926-y1rjgbui 244 7 in in IN cord-289926-y1rjgbui 244 8 support support NN cord-289926-y1rjgbui 244 9 of of IN cord-289926-y1rjgbui 244 10 SRY SRY NNP cord-289926-y1rjgbui 244 11 as as IN cord-289926-y1rjgbui 244 12 a a DT cord-289926-y1rjgbui 244 13 cellular cellular JJ cord-289926-y1rjgbui 244 14 counterpart counterpart NN cord-289926-y1rjgbui 244 15 of of IN cord-289926-y1rjgbui 244 16 HDAg HDAg NNS cord-289926-y1rjgbui 244 17 . . . cord-289926-y1rjgbui 245 1 1 1 LS cord-289926-y1rjgbui 245 2 . . . cord-289926-y1rjgbui 246 1 The the DT cord-289926-y1rjgbui 246 2 sequence sequence NN cord-289926-y1rjgbui 246 3 similarity similarity NN cord-289926-y1rjgbui 246 4 between between IN cord-289926-y1rjgbui 246 5 SRY sry NN cord-289926-y1rjgbui 246 6 and and CC cord-289926-y1rjgbui 246 7 HDAg hdag NN cord-289926-y1rjgbui 246 8 corresponds correspond VBZ cord-289926-y1rjgbui 246 9 to to IN cord-289926-y1rjgbui 246 10 the the DT cord-289926-y1rjgbui 246 11 functional functional JJ cord-289926-y1rjgbui 246 12 domains domain NNS cord-289926-y1rjgbui 246 13 experimentally experimentally RB cord-289926-y1rjgbui 246 14 identified identify VBN cord-289926-y1rjgbui 246 15 . . . cord-289926-y1rjgbui 247 1 2 2 LS cord-289926-y1rjgbui 247 2 . . . cord-289926-y1rjgbui 248 1 Sequence sequence NN cord-289926-y1rjgbui 248 2 similarity similarity NN cord-289926-y1rjgbui 248 3 is be VBZ cord-289926-y1rjgbui 248 4 restricted restrict VBN cord-289926-y1rjgbui 248 5 to to IN cord-289926-y1rjgbui 248 6 functional functional JJ cord-289926-y1rjgbui 248 7 domains domain NNS cord-289926-y1rjgbui 248 8 -as -as : cord-289926-y1rjgbui 248 9 expected expect VBN cord-289926-y1rjgbui 248 10 for for IN cord-289926-y1rjgbui 248 11 rapidly rapidly RB cord-289926-y1rjgbui 248 12 evolving evolve VBG cord-289926-y1rjgbui 248 13 RNA rna NN cord-289926-y1rjgbui 248 14 - - HYPH cord-289926-y1rjgbui 248 15 encoded encode VBN cord-289926-y1rjgbui 248 16 genes gene NNS cord-289926-y1rjgbui 248 17 . . . cord-289926-y1rjgbui 249 1 3 3 LS cord-289926-y1rjgbui 249 2 . . . cord-289926-y1rjgbui 250 1 Both both DT cord-289926-y1rjgbui 250 2 proteins protein NNS cord-289926-y1rjgbui 250 3 -SRY -sry VBP cord-289926-y1rjgbui 250 4 and and CC cord-289926-y1rjgbui 250 5 HDAg hdag NN cord-289926-y1rjgbui 250 6 -bind -bind HYPH cord-289926-y1rjgbui 250 7 nucleic nucleic JJ cord-289926-y1rjgbui 250 8 acids acid NNS cord-289926-y1rjgbui 250 9 and and CC cord-289926-y1rjgbui 250 10 are be VBP cord-289926-y1rjgbui 250 11 involved involve VBN cord-289926-y1rjgbui 250 12 in in IN cord-289926-y1rjgbui 250 13 transcription transcription NN cord-289926-y1rjgbui 250 14 . . . cord-289926-y1rjgbui 251 1 4 4 LS cord-289926-y1rjgbui 251 2 . . . cord-289926-y1rjgbui 252 1 Sequence sequence NN cord-289926-y1rjgbui 252 2 and and CC cord-289926-y1rjgbui 252 3 structure structure NN cord-289926-y1rjgbui 252 4 similarity similarity NN cord-289926-y1rjgbui 252 5 between between IN cord-289926-y1rjgbui 252 6 DNA dna NN cord-289926-y1rjgbui 252 7 - - HYPH cord-289926-y1rjgbui 252 8 binding binding NN cord-289926-y1rjgbui 252 9 to to IN cord-289926-y1rjgbui 252 10 RNA rna NN cord-289926-y1rjgbui 252 11 - - HYPH cord-289926-y1rjgbui 252 12 binding bind VBG cord-289926-y1rjgbui 252 13 motifs motif NNS cord-289926-y1rjgbui 252 14 is be VBZ cord-289926-y1rjgbui 252 15 supported support VBN cord-289926-y1rjgbui 252 16 by by IN cord-289926-y1rjgbui 252 17 a a DT cord-289926-y1rjgbui 252 18 number number NN cord-289926-y1rjgbui 252 19 of of IN cord-289926-y1rjgbui 252 20 recent recent JJ cord-289926-y1rjgbui 252 21 publications publication NNS cord-289926-y1rjgbui 252 22 . . . cord-289926-y1rjgbui 253 1 The the DT cord-289926-y1rjgbui 253 2 above above JJ cord-289926-y1rjgbui 253 3 arguments argument NNS cord-289926-y1rjgbui 253 4 make make VBP cord-289926-y1rjgbui 253 5 the the DT cord-289926-y1rjgbui 253 6 SRY SRY NNP cord-289926-y1rjgbui 253 7 protein protein NN cord-289926-y1rjgbui 253 8 a a DT cord-289926-y1rjgbui 253 9 strong strong JJ cord-289926-y1rjgbui 253 10 candidate candidate NN cord-289926-y1rjgbui 253 11 for for IN cord-289926-y1rjgbui 253 12 a a DT cord-289926-y1rjgbui 253 13 cellular cellular JJ cord-289926-y1rjgbui 253 14 counterpart counterpart NN cord-289926-y1rjgbui 253 15 of of IN cord-289926-y1rjgbui 253 16 HDAg HDAg NNS cord-289926-y1rjgbui 253 17 . . . cord-289926-y1rjgbui 254 1 Our -PRON- PRP$ cord-289926-y1rjgbui 254 2 hypothesis hypothesis NN cord-289926-y1rjgbui 254 3 predicts predict VBZ cord-289926-y1rjgbui 254 4 presence presence NN cord-289926-y1rjgbui 254 5 of of IN cord-289926-y1rjgbui 254 6 additional additional JJ cord-289926-y1rjgbui 254 7 nuclear nuclear JJ cord-289926-y1rjgbui 254 8 localization localization NN cord-289926-y1rjgbui 254 9 signals signal NNS cord-289926-y1rjgbui 254 10 within within IN cord-289926-y1rjgbui 254 11 ARMs arm NNS cord-289926-y1rjgbui 254 12 which which WDT cord-289926-y1rjgbui 254 13 was be VBD cord-289926-y1rjgbui 254 14 recently recently RB cord-289926-y1rjgbui 254 15 confirmed confirm VBN cord-289926-y1rjgbui 254 16 experimentally experimentally RB cord-289926-y1rjgbui 254 17 . . . cord-289926-y1rjgbui 255 1 It -PRON- PRP cord-289926-y1rjgbui 255 2 also also RB cord-289926-y1rjgbui 255 3 predicts predict VBZ cord-289926-y1rjgbui 255 4 structural structural JJ cord-289926-y1rjgbui 255 5 perturbation perturbation NN cord-289926-y1rjgbui 255 6 of of IN cord-289926-y1rjgbui 255 7 the the DT cord-289926-y1rjgbui 255 8 HDV HDV NNP cord-289926-y1rjgbui 255 9 RNA RNA NNP cord-289926-y1rjgbui 255 10 upon upon IN cord-289926-y1rjgbui 255 11 HDAg hdag NN cord-289926-y1rjgbui 255 12 binding binding NN cord-289926-y1rjgbui 255 13 , , , cord-289926-y1rjgbui 255 14 and and CC cord-289926-y1rjgbui 255 15 possible possible JJ cord-289926-y1rjgbui 255 16 specific specific JJ cord-289926-y1rjgbui 255 17 binding binding NN cord-289926-y1rjgbui 255 18 between between IN cord-289926-y1rjgbui 255 19 HDAg HDAg NNS cord-289926-y1rjgbui 255 20 and and CC cord-289926-y1rjgbui 255 21 the the DT cord-289926-y1rjgbui 255 22 regulatory regulatory JJ cord-289926-y1rjgbui 255 23 regions region NNS cord-289926-y1rjgbui 255 24 of of IN cord-289926-y1rjgbui 255 25 cellular cellular JJ cord-289926-y1rjgbui 255 26 proto proto JJ cord-289926-y1rjgbui 255 27 - - HYPH cord-289926-y1rjgbui 255 28 oncogenes oncogene NNS cord-289926-y1rjgbui 255 29 . . . cord-289926-y1rjgbui 256 1 Testing test VBG cord-289926-y1rjgbui 256 2 these these DT cord-289926-y1rjgbui 256 3 predictions prediction NNS cord-289926-y1rjgbui 256 4 and and CC cord-289926-y1rjgbui 256 5 determining determine VBG cord-289926-y1rjgbui 256 6 the the DT cord-289926-y1rjgbui 256 7 structure structure NN cord-289926-y1rjgbui 256 8 of of IN cord-289926-y1rjgbui 256 9 HDAg HDAg NNS cord-289926-y1rjgbui 256 10 may may MD cord-289926-y1rjgbui 256 11 shed shed VB cord-289926-y1rjgbui 256 12 further further JJ cord-289926-y1rjgbui 256 13 light light NN cord-289926-y1rjgbui 256 14 on on IN cord-289926-y1rjgbui 256 15 possible possible JJ cord-289926-y1rjgbui 256 16 evolutionary evolutionary JJ cord-289926-y1rjgbui 256 17 relationship relationship NN cord-289926-y1rjgbui 256 18 between between IN cord-289926-y1rjgbui 256 19 the the DT cord-289926-y1rjgbui 256 20 HMG HMG NNP cord-289926-y1rjgbui 256 21 domain domain NN cord-289926-y1rjgbui 256 22 of of IN cord-289926-y1rjgbui 256 23 SRY SRY NNP cord-289926-y1rjgbui 256 24 and and CC cord-289926-y1rjgbui 256 25 the the DT cord-289926-y1rjgbui 256 26 RNA RNA NNP cord-289926-y1rjgbui 256 27 binding binding NN cord-289926-y1rjgbui 256 28 domain domain NN cord-289926-y1rjgbui 256 29 of of IN cord-289926-y1rjgbui 256 30 HDAg HDAg NNS cord-289926-y1rjgbui 256 31 . . . cord-289926-y1rjgbui 257 1 The the DT cord-289926-y1rjgbui 257 2 intracisternal intracisternal JJ cord-289926-y1rjgbui 257 3 A a NN cord-289926-y1rjgbui 257 4 - - HYPH cord-289926-y1rjgbui 257 5 particle particle NN cord-289926-y1rjgbui 257 6 proximal proximal JJ cord-289926-y1rjgbui 257 7 enhancer enhancer NN cord-289926-y1rjgbui 257 8 - - HYPH cord-289926-y1rjgbui 257 9 binding bind VBG cord-289926-y1rjgbui 257 10 protein protein NN cord-289926-y1rjgbui 257 11 activates activate VBZ cord-289926-y1rjgbui 257 12 transcription transcription NN cord-289926-y1rjgbui 257 13 and and CC cord-289926-y1rjgbui 257 14 is be VBZ cord-289926-y1rjgbui 257 15 identical identical JJ cord-289926-y1rjgbui 257 16 to to IN cord-289926-y1rjgbui 257 17 the the DT cord-289926-y1rjgbui 257 18 RNA RNA NNP cord-289926-y1rjgbui 257 19 - - : cord-289926-y1rjgbui 257 20 and and CC cord-289926-y1rjgbui 257 21 DNAbinding DNAbinding NNP cord-289926-y1rjgbui 257 22 protein protein NN cord-289926-y1rjgbui 258 1 p54nrb p54nrb NNP cord-289926-y1rjgbui 259 1 / / NFP cord-289926-y1rjgbui 260 1 NonO NonO NNP cord-289926-y1rjgbui 261 1 The the DT cord-289926-y1rjgbui 261 2 HMG-1 HMG-1 NNP cord-289926-y1rjgbui 261 3 box box NN cord-289926-y1rjgbui 261 4 protein protein NN cord-289926-y1rjgbui 261 5 family family NN cord-289926-y1rjgbui 261 6 : : : cord-289926-y1rjgbui 261 7 classification classification NN cord-289926-y1rjgbui 261 8 and and CC cord-289926-y1rjgbui 261 9 functional functional JJ cord-289926-y1rjgbui 261 10 relationship relationship NN cord-289926-y1rjgbui 262 1 An an DT cord-289926-y1rjgbui 262 2 ultra ultra JJ cord-289926-y1rjgbui 262 3 - - JJ cord-289926-y1rjgbui 262 4 sensitive sensitive JJ cord-289926-y1rjgbui 262 5 RNA RNA NNP cord-289926-y1rjgbui 262 6 structural structural JJ cord-289926-y1rjgbui 262 7 element element NN cord-289926-y1rjgbui 262 8 in in IN cord-289926-y1rjgbui 262 9 viroid viroid JJ cord-289926-y1rjgbui 262 10 - - HYPH cord-289926-y1rjgbui 262 11 like like JJ cord-289926-y1rjgbui 262 12 domain domain NN cord-289926-y1rjgbui 262 13 of of IN cord-289926-y1rjgbui 262 14 hepatitis hepatitis NN cord-289926-y1rjgbui 262 15 delta delta NNP cord-289926-y1rjgbui 262 16 virus virus NN cord-289926-y1rjgbui 262 17 Delta Delta NNP cord-289926-y1rjgbui 262 18 - - : cord-289926-y1rjgbui 262 19 interacting interact VBG cord-289926-y1rjgbui 262 20 protein protein NN cord-289926-y1rjgbui 262 21 A a NN cord-289926-y1rjgbui 262 22 and and CC cord-289926-y1rjgbui 262 23 the the DT cord-289926-y1rjgbui 262 24 origin origin NN cord-289926-y1rjgbui 262 25 of of IN cord-289926-y1rjgbui 262 26 the the DT cord-289926-y1rjgbui 262 27 hepatitis hepatitis NNP cord-289926-y1rjgbui 262 28 delta delta NNP cord-289926-y1rjgbui 262 29 virus virus NN cord-289926-y1rjgbui 263 1 A a DT cord-289926-y1rjgbui 263 2 cellular cellular JJ cord-289926-y1rjgbui 263 3 homolog homolog NN cord-289926-y1rjgbui 263 4 of of IN cord-289926-y1rjgbui 263 5 hepatitis hepatitis NNP cord-289926-y1rjgbui 263 6 delta delta NNP cord-289926-y1rjgbui 263 7 antigen antigen NN cord-289926-y1rjgbui 263 8 : : : cord-289926-y1rjgbui 263 9 implications implication NNS cord-289926-y1rjgbui 263 10 for for IN cord-289926-y1rjgbui 263 11 viral viral JJ cord-289926-y1rjgbui 263 12 replication replication NN cord-289926-y1rjgbui 263 13 and and CC cord-289926-y1rjgbui 263 14 evolution evolution NN cord-289926-y1rjgbui 263 15 Sequence sequence NN cord-289926-y1rjgbui 263 16 - - HYPH cord-289926-y1rjgbui 263 17 specific specific JJ cord-289926-y1rjgbui 263 18 RNA RNA NNP cord-289926-y1rjgbui 263 19 binding binding NN cord-289926-y1rjgbui 263 20 by by IN cord-289926-y1rjgbui 263 21 bicoid bicoid NNP cord-289926-y1rjgbui 263 22 Role role NN cord-289926-y1rjgbui 263 23 of of IN cord-289926-y1rjgbui 263 24 two two CD cord-289926-y1rjgbui 263 25 forms form NNS cord-289926-y1rjgbui 263 26 of of IN cord-289926-y1rjgbui 263 27 hepatitis hepatitis NNP cord-289926-y1rjgbui 263 28 delta delta NNP cord-289926-y1rjgbui 263 29 virus virus NN cord-289926-y1rjgbui 263 30 antigen antigen NN cord-289926-y1rjgbui 263 31 : : : cord-289926-y1rjgbui 263 32 evidence evidence NN cord-289926-y1rjgbui 263 33 for for IN cord-289926-y1rjgbui 263 34 a a DT cord-289926-y1rjgbui 263 35 mechanism mechanism NN cord-289926-y1rjgbui 263 36 of of IN cord-289926-y1rjgbui 263 37 self self NN cord-289926-y1rjgbui 263 38 - - HYPH cord-289926-y1rjgbui 263 39 limiting limit VBG cord-289926-y1rjgbui 263 40 genome genome NN cord-289926-y1rjgbui 263 41 replication replication NN cord-289926-y1rjgbui 263 42 Structure Structure NNP cord-289926-y1rjgbui 263 43 and and CC cord-289926-y1rjgbui 263 44 the the DT cord-289926-y1rjgbui 263 45 replication replication NN cord-289926-y1rjgbui 263 46 of of IN cord-289926-y1rjgbui 263 47 the the DT cord-289926-y1rjgbui 263 48 genome genome NN cord-289926-y1rjgbui 263 49 of of IN cord-289926-y1rjgbui 263 50 hepatitis hepatitis NNP cord-289926-y1rjgbui 263 51 delta delta NNP cord-289926-y1rjgbui 263 52 virus virus NN cord-289926-y1rjgbui 263 53 Hepatitis Hepatitis NNP cord-289926-y1rjgbui 263 54 delta delta NN cord-289926-y1rjgbui 263 55 antigen antigen NN cord-289926-y1rjgbui 263 56 mediates mediate VBZ cord-289926-y1rjgbui 263 57 the the DT cord-289926-y1rjgbui 263 58 nuclear nuclear JJ cord-289926-y1rjgbui 263 59 import import NN cord-289926-y1rjgbui 263 60 of of IN cord-289926-y1rjgbui 263 61 hepatitis hepatitis NNP cord-289926-y1rjgbui 263 62 delta delta NNP cord-289926-y1rjgbui 263 63 virus virus NN cord-289926-y1rjgbui 263 64 RNA RNA NNP cord-289926-y1rjgbui 263 65 SRY SRY NNP cord-289926-y1rjgbui 263 66 protein protein NN cord-289926-y1rjgbui 263 67 enhances enhance VBZ cord-289926-y1rjgbui 263 68 transcription transcription NN cord-289926-y1rjgbui 263 69 of of IN cord-289926-y1rjgbui 263 70 Fos Fos NNP cord-289926-y1rjgbui 263 71 - - HYPH cord-289926-y1rjgbui 263 72 related relate VBN cord-289926-y1rjgbui 263 73 antigen antigen NN cord-289926-y1rjgbui 263 74 1 1 CD cord-289926-y1rjgbui 263 75 promoter promoter NN cord-289926-y1rjgbui 263 76 constructs construct VBZ cord-289926-y1rjgbui 263 77 The the DT cord-289926-y1rjgbui 263 78 significance significance NN cord-289926-y1rjgbui 263 79 of of IN cord-289926-y1rjgbui 263 80 protein protein NN cord-289926-y1rjgbui 263 81 sequence sequence NN cord-289926-y1rjgbui 264 1 similarities similarity NNS cord-289926-y1rjgbui 264 2 A a DT cord-289926-y1rjgbui 264 3 model model NN cord-289926-y1rjgbui 264 4 of of IN cord-289926-y1rjgbui 264 5 evolutionary evolutionary JJ cord-289926-y1rjgbui 264 6 changes change NNS cord-289926-y1rjgbui 264 7 in in IN cord-289926-y1rjgbui 264 8 protein protein NN cord-289926-y1rjgbui 265 1 The the DT cord-289926-y1rjgbui 265 2 embryonic embryonic JJ cord-289926-y1rjgbui 265 3 enhancer enhancer NN cord-289926-y1rjgbui 265 4 - - HYPH cord-289926-y1rjgbui 265 5 binding bind VBG cord-289926-y1rjgbui 265 6 protein protein NN cord-289926-y1rjgbui 265 7 SSAP SSAP NNP cord-289926-y1rjgbui 265 8 contains contain VBZ cord-289926-y1rjgbui 265 9 a a DT cord-289926-y1rjgbui 265 10 novel novel JJ cord-289926-y1rjgbui 265 11 DNA dna NN cord-289926-y1rjgbui 265 12 - - HYPH cord-289926-y1rjgbui 265 13 binding bind VBG cord-289926-y1rjgbui 265 14 domain domain NN cord-289926-y1rjgbui 265 15 which which WDT cord-289926-y1rjgbui 265 16 has have VBZ cord-289926-y1rjgbui 265 17 homology homology NN cord-289926-y1rjgbui 265 18 to to IN cord-289926-y1rjgbui 265 19 several several JJ cord-289926-y1rjgbui 265 20 RNA rna NN cord-289926-y1rjgbui 265 21 - - HYPH cord-289926-y1rjgbui 265 22 binding bind VBG cord-289926-y1rjgbui 265 23 proteins protein NNS cord-289926-y1rjgbui 265 24 RNA RNA NNP cord-289926-y1rjgbui 265 25 recognition recognition NN cord-289926-y1rjgbui 265 26 and and CC cord-289926-y1rjgbui 265 27 translational translational JJ cord-289926-y1rjgbui 265 28 regulation regulation NN cord-289926-y1rjgbui 265 29 by by IN cord-289926-y1rjgbui 265 30 a a DT cord-289926-y1rjgbui 265 31 homeodomain homeodomain NN cord-289926-y1rjgbui 265 32 protein protein NN cord-289926-y1rjgbui 265 33 Sequence sequence NN cord-289926-y1rjgbui 265 34 and and CC cord-289926-y1rjgbui 265 35 expression expression NN cord-289926-y1rjgbui 265 36 of of IN cord-289926-y1rjgbui 265 37 Sox-18 Sox-18 NNP cord-289926-y1rjgbui 265 38 , , , cord-289926-y1rjgbui 265 39 a a DT cord-289926-y1rjgbui 265 40 new new JJ cord-289926-y1rjgbui 265 41 HMG HMG NNP cord-289926-y1rjgbui 265 42 - - HYPH cord-289926-y1rjgbui 265 43 box box NN cord-289926-y1rjgbui 265 44 transcription transcription NN cord-289926-y1rjgbui 265 45 factor factor NN cord-289926-y1rjgbui 266 1 The the DT cord-289926-y1rjgbui 266 2 intracellular intracellular JJ cord-289926-y1rjgbui 266 3 distribution distribution NN cord-289926-y1rjgbui 266 4 and and CC cord-289926-y1rjgbui 266 5 function function NN cord-289926-y1rjgbui 266 6 group group NN cord-289926-y1rjgbui 266 7 of of IN cord-289926-y1rjgbui 266 8 the the DT cord-289926-y1rjgbui 266 9 high high JJ cord-289926-y1rjgbui 266 10 mobility mobility NN cord-289926-y1rjgbui 266 11 chromosomal chromosomal NN cord-289926-y1rjgbui 266 12 proteins protein NNS cord-289926-y1rjgbui 266 13 Phylogeny phylogeny NN cord-289926-y1rjgbui 266 14 of of IN cord-289926-y1rjgbui 266 15 viroids viroid NNS cord-289926-y1rjgbui 266 16 , , , cord-289926-y1rjgbui 266 17 viroidlike viroidlike NNP cord-289926-y1rjgbui 266 18 satellite satellite NN cord-289926-y1rjgbui 266 19 RNAs rna NNS cord-289926-y1rjgbui 266 20 , , , cord-289926-y1rjgbui 266 21 and and CC cord-289926-y1rjgbui 266 22 the the DT cord-289926-y1rjgbui 266 23 viroidlike viroidlike JJ cord-289926-y1rjgbui 266 24 domain domain NN cord-289926-y1rjgbui 266 25 of of IN cord-289926-y1rjgbui 266 26 hepatitis hepatitis NNP cord-289926-y1rjgbui 266 27 delta delta NNP cord-289926-y1rjgbui 266 28 virus virus NN cord-289926-y1rjgbui 266 29 RNA RNA NNP cord-289926-y1rjgbui 266 30 Influence Influence NNP cord-289926-y1rjgbui 266 31 of of IN cord-289926-y1rjgbui 266 32 hepatitis hepatitis NNP cord-289926-y1rjgbui 266 33 delta delta NNP cord-289926-y1rjgbui 266 34 virus virus NN cord-289926-y1rjgbui 266 35 infection infection NN cord-289926-y1rjgbui 266 36 on on IN cord-289926-y1rjgbui 266 37 progression progression NN cord-289926-y1rjgbui 266 38 to to IN cord-289926-y1rjgbui 266 39 cirrhosis cirrhosis NN cord-289926-y1rjgbui 266 40 in in IN cord-289926-y1rjgbui 266 41 chronic chronic JJ cord-289926-y1rjgbui 266 42 hepatitis hepatitis NN cord-289926-y1rjgbui 266 43 type type NN cord-289926-y1rjgbui 266 44 B B NNP cord-289926-y1rjgbui 266 45 Maximum Maximum NNP cord-289926-y1rjgbui 266 46 - - HYPH cord-289926-y1rjgbui 266 47 likelihood likelihood NN cord-289926-y1rjgbui 266 48 estimation estimation NN cord-289926-y1rjgbui 266 49 of of IN cord-289926-y1rjgbui 266 50 evolutionary evolutionary JJ cord-289926-y1rjgbui 266 51 trees tree NNS cord-289926-y1rjgbui 266 52 from from IN cord-289926-y1rjgbui 266 53 continuous continuous JJ cord-289926-y1rjgbui 266 54 characters character NNS cord-289926-y1rjgbui 266 55 Progressive progressive JJ cord-289926-y1rjgbui 266 56 sequence sequence NN cord-289926-y1rjgbui 266 57 alignment alignment NN cord-289926-y1rjgbui 266 58 as as IN cord-289926-y1rjgbui 266 59 a a DT cord-289926-y1rjgbui 266 60 prerequisite prerequisite NN cord-289926-y1rjgbui 266 61 to to TO cord-289926-y1rjgbui 266 62 correct correct VB cord-289926-y1rjgbui 266 63 phylogenetic phylogenetic JJ cord-289926-y1rjgbui 266 64 trees tree NNS cord-289926-y1rjgbui 267 1 An an DT cord-289926-y1rjgbui 267 2 SRY sry NN cord-289926-y1rjgbui 267 3 - - HYPH cord-289926-y1rjgbui 267 4 related relate VBN cord-289926-y1rjgbui 267 5 sequence sequence NN cord-289926-y1rjgbui 267 6 of of IN cord-289926-y1rjgbui 267 7 the the DT cord-289926-y1rjgbui 267 8 marsupial marsupial JJ cord-289926-y1rjgbui 267 9 X X NNP cord-289926-y1rjgbui 267 10 chromosome chromosome NN cord-289926-y1rjgbui 267 11 : : : cord-289926-y1rjgbui 267 12 implications implication NNS cord-289926-y1rjgbui 267 13 for for IN cord-289926-y1rjgbui 267 14 the the DT cord-289926-y1rjgbui 267 15 evolution evolution NN cord-289926-y1rjgbui 267 16 of of IN cord-289926-y1rjgbui 267 17 the the DT cord-289926-y1rjgbui 267 18 mammalian mammalian JJ cord-289926-y1rjgbui 267 19 testis testis NN cord-289926-y1rjgbui 267 20 - - HYPH cord-289926-y1rjgbui 267 21 determining determine VBG cord-289926-y1rjgbui 267 22 gene gene NN cord-289926-y1rjgbui 268 1 The the DT cord-289926-y1rjgbui 268 2 RNAs rna NNS cord-289926-y1rjgbui 268 3 of of IN cord-289926-y1rjgbui 268 4 hepatitis hepatitis NNP cord-289926-y1rjgbui 268 5 delta delta NNP cord-289926-y1rjgbui 268 6 virus virus NN cord-289926-y1rjgbui 268 7 are be VBP cord-289926-y1rjgbui 268 8 copied copy VBN cord-289926-y1rjgbui 268 9 by by IN cord-289926-y1rjgbui 268 10 RNA RNA NNP cord-289926-y1rjgbui 268 11 polymerase polymerase NN cord-289926-y1rjgbui 268 12 II II NNP cord-289926-y1rjgbui 268 13 in in IN cord-289926-y1rjgbui 268 14 nuclear nuclear JJ cord-289926-y1rjgbui 268 15 homogenates homogenate NNS cord-289926-y1rjgbui 268 16 Identity identity NN cord-289926-y1rjgbui 268 17 of of IN cord-289926-y1rjgbui 268 18 the the DT cord-289926-y1rjgbui 268 19 RNA RNA NNP cord-289926-y1rjgbui 268 20 - - HYPH cord-289926-y1rjgbui 268 21 binding bind VBG cord-289926-y1rjgbui 268 22 protein protein NN cord-289926-y1rjgbui 268 23 K k NN cord-289926-y1rjgbui 268 24 of of IN cord-289926-y1rjgbui 268 25 hnRNP hnrnp DT cord-289926-y1rjgbui 268 26 particles particle NNS cord-289926-y1rjgbui 268 27 with with IN cord-289926-y1rjgbui 268 28 protein protein NN cord-289926-y1rjgbui 268 29 H16 H16 NNP cord-289926-y1rjgbui 268 30 , , , cord-289926-y1rjgbui 268 31 a a DT cord-289926-y1rjgbui 268 32 sequence sequence NN cord-289926-y1rjgbui 268 33 - - HYPH cord-289926-y1rjgbui 268 34 specific specific JJ cord-289926-y1rjgbui 268 35 single single JJ cord-289926-y1rjgbui 268 36 strand strand NN cord-289926-y1rjgbui 268 37 DNA dna NN cord-289926-y1rjgbui 268 38 - - HYPH cord-289926-y1rjgbui 268 39 binding bind VBG cord-289926-y1rjgbui 268 40 protein protein NN cord-289926-y1rjgbui 269 1 The the DT cord-289926-y1rjgbui 269 2 HMG HMG NNP cord-289926-y1rjgbui 269 3 domain domain NN cord-289926-y1rjgbui 269 4 of of IN cord-289926-y1rjgbui 269 5 lymphoid lymphoid JJ cord-289926-y1rjgbui 269 6 enhancer enhancer NN cord-289926-y1rjgbui 269 7 factor factor NN cord-289926-y1rjgbui 269 8 1 1 CD cord-289926-y1rjgbui 269 9 bends bend VBZ cord-289926-y1rjgbui 269 10 DNA dna NN cord-289926-y1rjgbui 269 11 and and CC cord-289926-y1rjgbui 269 12 facilitates facilitate VBZ cord-289926-y1rjgbui 269 13 assembly assembly NN cord-289926-y1rjgbui 269 14 of of IN cord-289926-y1rjgbui 269 15 functional functional JJ cord-289926-y1rjgbui 269 16 nucleoprotein nucleoprotein JJ cord-289926-y1rjgbui 269 17 structures structure NNS cord-289926-y1rjgbui 269 18 Trans Trans NNP cord-289926-y1rjgbui 269 19 - - JJ cord-289926-y1rjgbui 269 20 dominant dominant JJ cord-289926-y1rjgbui 269 21 inhibition inhibition NN cord-289926-y1rjgbui 269 22 of of IN cord-289926-y1rjgbui 269 23 human human JJ cord-289926-y1rjgbui 269 24 hepatitis hepatitis NNP cord-289926-y1rjgbui 269 25 delta delta NNP cord-289926-y1rjgbui 269 26 virus virus NN cord-289926-y1rjgbui 269 27 genome genome NN cord-289926-y1rjgbui 269 28 replication replication NN cord-289926-y1rjgbui 269 29 Profile Profile NNP cord-289926-y1rjgbui 269 30 analysis analysis NN cord-289926-y1rjgbui 269 31 : : : cord-289926-y1rjgbui 269 32 detection detection NN cord-289926-y1rjgbui 269 33 of of IN cord-289926-y1rjgbui 269 34 distantly distantly RB cord-289926-y1rjgbui 269 35 related relate VBN cord-289926-y1rjgbui 269 36 proteins protein NNS cord-289926-y1rjgbui 269 37 Identification identification NN cord-289926-y1rjgbui 269 38 of of IN cord-289926-y1rjgbui 269 39 sequence sequence NN cord-289926-y1rjgbui 269 40 pattern pattern NN cord-289926-y1rjgbui 269 41 with with IN cord-289926-y1rjgbui 269 42 profile profile NN cord-289926-y1rjgbui 269 43 analysis analysis NN cord-289926-y1rjgbui 269 44 Ribosomal Ribosomal NNP cord-289926-y1rjgbui 269 45 protein protein NN cord-289926-y1rjgbui 269 46 S7 S7 NNP cord-289926-y1rjgbui 269 47 : : : cord-289926-y1rjgbui 269 48 a a DT cord-289926-y1rjgbui 269 49 new new JJ cord-289926-y1rjgbui 269 50 RNA rna NN cord-289926-y1rjgbui 269 51 - - HYPH cord-289926-y1rjgbui 269 52 binding bind VBG cord-289926-y1rjgbui 269 53 motif motif NN cord-289926-y1rjgbui 269 54 with with IN cord-289926-y1rjgbui 269 55 structural structural JJ cord-289926-y1rjgbui 269 56 similarities similarity NNS cord-289926-y1rjgbui 269 57 to to IN cord-289926-y1rjgbui 269 58 a a DT cord-289926-y1rjgbui 269 59 DNA dna NN cord-289926-y1rjgbui 269 60 architectural architectural JJ cord-289926-y1rjgbui 269 61 factor factor NN cord-289926-y1rjgbui 269 62 Methods method NNS cord-289926-y1rjgbui 269 63 for for IN cord-289926-y1rjgbui 269 64 assessing assess VBG cord-289926-y1rjgbui 269 65 the the DT cord-289926-y1rjgbui 269 66 statistical statistical JJ cord-289926-y1rjgbui 269 67 significance significance NN cord-289926-y1rjgbui 269 68 of of IN cord-289926-y1rjgbui 269 69 molecular molecular JJ cord-289926-y1rjgbui 269 70 sequence sequence NN cord-289926-y1rjgbui 269 71 features feature NNS cord-289926-y1rjgbui 269 72 by by IN cord-289926-y1rjgbui 269 73 using use VBG cord-289926-y1rjgbui 269 74 general general JJ cord-289926-y1rjgbui 269 75 scoring scoring NN cord-289926-y1rjgbui 269 76 scheme scheme NN cord-289926-y1rjgbui 270 1 The the DT cord-289926-y1rjgbui 270 2 molecular molecular JJ cord-289926-y1rjgbui 270 3 biology biology NN cord-289926-y1rjgbui 270 4 of˙hepatitis of˙hepatitis IN cord-289926-y1rjgbui 270 5 delta delta NN cord-289926-y1rjgbui 270 6 virus virus NN cord-289926-y1rjgbui 270 7 Ancestry ancestry NN cord-289926-y1rjgbui 270 8 and and CC cord-289926-y1rjgbui 270 9 diversity diversity NN cord-289926-y1rjgbui 270 10 of of IN cord-289926-y1rjgbui 270 11 the the DT cord-289926-y1rjgbui 270 12 HMG HMG NNP cord-289926-y1rjgbui 270 13 box box NN cord-289926-y1rjgbui 270 14 superfamily superfamily NN cord-289926-y1rjgbui 270 15 RNA RNA NNP cord-289926-y1rjgbui 270 16 - - HYPH cord-289926-y1rjgbui 270 17 binding bind VBG cord-289926-y1rjgbui 270 18 activity activity NN cord-289926-y1rjgbui 270 19 of of IN cord-289926-y1rjgbui 270 20 hepatitis hepatitis NN cord-289926-y1rjgbui 270 21 delta delta NNP cord-289926-y1rjgbui 270 22 antigen antigen NNP cord-289926-y1rjgbui 270 23 involves involve VBZ cord-289926-y1rjgbui 270 24 two two CD cord-289926-y1rjgbui 270 25 arginine arginine NN cord-289926-y1rjgbui 270 26 - - HYPH cord-289926-y1rjgbui 270 27 rich rich JJ cord-289926-y1rjgbui 270 28 motifs motif NNS cord-289926-y1rjgbui 270 29 and and CC cord-289926-y1rjgbui 270 30 is be VBZ cord-289926-y1rjgbui 270 31 required require VBN cord-289926-y1rjgbui 270 32 for for IN cord-289926-y1rjgbui 270 33 hepatitis hepatitis NNP cord-289926-y1rjgbui 270 34 delta delta NNP cord-289926-y1rjgbui 270 35 virus virus NN cord-289926-y1rjgbui 270 36 RNA RNA NNP cord-289926-y1rjgbui 270 37 replication replication NN cord-289926-y1rjgbui 270 38 Characterization characterization NN cord-289926-y1rjgbui 270 39 of of IN cord-289926-y1rjgbui 270 40 hepatitis hepatitis NNP cord-289926-y1rjgbui 270 41 delta delta NNP cord-289926-y1rjgbui 270 42 antigen antigen NN cord-289926-y1rjgbui 270 43 : : : cord-289926-y1rjgbui 270 44 specific specific JJ cord-289926-y1rjgbui 270 45 binding binding NN cord-289926-y1rjgbui 270 46 to to IN cord-289926-y1rjgbui 270 47 hepatitis hepatitis NNP cord-289926-y1rjgbui 270 48 delta delta NNP cord-289926-y1rjgbui 270 49 virus virus NN cord-289926-y1rjgbui 270 50 RNA RNA NNP cord-289926-y1rjgbui 270 51 Delta Delta NNP cord-289926-y1rjgbui 270 52 -interacting -interacte VBG cord-289926-y1rjgbui 270 53 protein protein NN cord-289926-y1rjgbui 270 54 A A NNP cord-289926-y1rjgbui 270 55 and and CC cord-289926-y1rjgbui 270 56 the the DT cord-289926-y1rjgbui 270 57 origin origin NN cord-289926-y1rjgbui 270 58 of of IN cord-289926-y1rjgbui 270 59 hepatitis hepatitis NNP cord-289926-y1rjgbui 270 60 delta delta NNP cord-289926-y1rjgbui 270 61 virus virus NN cord-289926-y1rjgbui 271 1 A a DT cord-289926-y1rjgbui 271 2 general general JJ cord-289926-y1rjgbui 271 3 method method NN cord-289926-y1rjgbui 271 4 applicable applicable JJ cord-289926-y1rjgbui 271 5 to to IN cord-289926-y1rjgbui 271 6 the the DT cord-289926-y1rjgbui 271 7 search search NN cord-289926-y1rjgbui 271 8 for for IN cord-289926-y1rjgbui 271 9 similarities similarity NNS cord-289926-y1rjgbui 271 10 in in IN cord-289926-y1rjgbui 271 11 the the DT cord-289926-y1rjgbui 271 12 amino amino NN cord-289926-y1rjgbui 271 13 acid acid NN cord-289926-y1rjgbui 271 14 sequence sequence NN cord-289926-y1rjgbui 271 15 of of IN cord-289926-y1rjgbui 271 16 two two CD cord-289926-y1rjgbui 271 17 proteins protein NNS cord-289926-y1rjgbui 271 18 Homology homology NN cord-289926-y1rjgbui 271 19 in in IN cord-289926-y1rjgbui 271 20 classical classical JJ cord-289926-y1rjgbui 271 21 and and CC cord-289926-y1rjgbui 271 22 molecular molecular JJ cord-289926-y1rjgbui 271 23 biology biology NN cord-289926-y1rjgbui 271 24 Replication replication NN cord-289926-y1rjgbui 271 25 of of IN cord-289926-y1rjgbui 271 26 the the DT cord-289926-y1rjgbui 271 27 hepatitis hepatitis NN cord-289926-y1rjgbui 271 28 delta delta NNP cord-289926-y1rjgbui 271 29 virus virus NN cord-289926-y1rjgbui 271 30 RNA RNA NNP cord-289926-y1rjgbui 271 31 in in IN cord-289926-y1rjgbui 271 32 mice mouse NNS cord-289926-y1rjgbui 271 33 after after IN cord-289926-y1rjgbui 271 34 intramuscular intramuscular JJ cord-289926-y1rjgbui 271 35 injection injection NN cord-289926-y1rjgbui 271 36 of of IN cord-289926-y1rjgbui 271 37 plasmid plasmid NN cord-289926-y1rjgbui 271 38 DNA DNA NNP cord-289926-y1rjgbui 271 39 Solution Solution NNP cord-289926-y1rjgbui 271 40 structure structure NN cord-289926-y1rjgbui 271 41 of of IN cord-289926-y1rjgbui 271 42 a a DT cord-289926-y1rjgbui 271 43 DNA dna NN cord-289926-y1rjgbui 271 44 - - HYPH cord-289926-y1rjgbui 271 45 binding bind VBG cord-289926-y1rjgbui 271 46 domain domain NN cord-289926-y1rjgbui 271 47 from from IN cord-289926-y1rjgbui 271 48 HMG1 HMG1 NNP cord-289926-y1rjgbui 271 49 Replication Replication NNP cord-289926-y1rjgbui 271 50 and and CC cord-289926-y1rjgbui 271 51 evolution evolution NN cord-289926-y1rjgbui 271 52 of of IN cord-289926-y1rjgbui 271 53 viroid viroid JJ cord-289926-y1rjgbui 271 54 - - HYPH cord-289926-y1rjgbui 271 55 like like JJ cord-289926-y1rjgbui 271 56 pathogens pathogen NNS cord-289926-y1rjgbui 272 1 A a DT cord-289926-y1rjgbui 272 2 gene gene NN cord-289926-y1rjgbui 272 3 from from IN cord-289926-y1rjgbui 272 4 the the DT cord-289926-y1rjgbui 272 5 human human JJ cord-289926-y1rjgbui 272 6 sexdetermining sexdetermining NN cord-289926-y1rjgbui 272 7 region region NN cord-289926-y1rjgbui 272 8 encodes encode VBZ cord-289926-y1rjgbui 272 9 a a DT cord-289926-y1rjgbui 272 10 protein protein NN cord-289926-y1rjgbui 272 11 with with IN cord-289926-y1rjgbui 272 12 homology homology NN cord-289926-y1rjgbui 272 13 to to IN cord-289926-y1rjgbui 272 14 a a DT cord-289926-y1rjgbui 272 15 conserved conserve VBN cord-289926-y1rjgbui 272 16 DNA dna NN cord-289926-y1rjgbui 272 17 - - HYPH cord-289926-y1rjgbui 272 18 binding bind VBG cord-289926-y1rjgbui 272 19 motif motif NN cord-289926-y1rjgbui 272 20 RNA rna NN cord-289926-y1rjgbui 272 21 - - HYPH cord-289926-y1rjgbui 272 22 binding bind VBG cord-289926-y1rjgbui 272 23 proteins protein NNS cord-289926-y1rjgbui 272 24 as as IN cord-289926-y1rjgbui 272 25 regulators regulator NNS cord-289926-y1rjgbui 272 26 of of IN cord-289926-y1rjgbui 272 27 gene gene NN cord-289926-y1rjgbui 272 28 expression expression NN cord-289926-y1rjgbui 272 29 Comparison Comparison NNP cord-289926-y1rjgbui 272 30 in in IN cord-289926-y1rjgbui 272 31 biosequences biosequence NNS cord-289926-y1rjgbui 272 32 Two two CD cord-289926-y1rjgbui 272 33 independent independent JJ cord-289926-y1rjgbui 272 34 nuclear nuclear JJ cord-289926-y1rjgbui 272 35 localization localization NN cord-289926-y1rjgbui 272 36 signals signal NNS cord-289926-y1rjgbui 272 37 are be VBP cord-289926-y1rjgbui 272 38 present present JJ cord-289926-y1rjgbui 272 39 in in IN cord-289926-y1rjgbui 272 40 the the DT cord-289926-y1rjgbui 272 41 DNA dna NN cord-289926-y1rjgbui 272 42 - - HYPH cord-289926-y1rjgbui 272 43 binding bind VBG cord-289926-y1rjgbui 272 44 high high JJ cord-289926-y1rjgbui 272 45 - - HYPH cord-289926-y1rjgbui 272 46 mobility mobility NN cord-289926-y1rjgbui 272 47 group group NN cord-289926-y1rjgbui 272 48 domains domain NNS cord-289926-y1rjgbui 272 49 of of IN cord-289926-y1rjgbui 272 50 SRY SRY NNP cord-289926-y1rjgbui 272 51 and and CC cord-289926-y1rjgbui 272 52 SOX9 SOX9 NNP cord-289926-y1rjgbui 272 53 RNA RNA NNP cord-289926-y1rjgbui 272 54 recognition recognition NN cord-289926-y1rjgbui 272 55 by by IN cord-289926-y1rjgbui 272 56 an an DT cord-289926-y1rjgbui 272 57 isolated isolated JJ cord-289926-y1rjgbui 272 58 a a DT cord-289926-y1rjgbui 272 59 helix helix NN cord-289926-y1rjgbui 272 60 Structural structural JJ cord-289926-y1rjgbui 272 61 variety variety NN cord-289926-y1rjgbui 272 62 of of IN cord-289926-y1rjgbui 272 63 arginine arginine NN cord-289926-y1rjgbui 272 64 - - HYPH cord-289926-y1rjgbui 272 65 rich rich JJ cord-289926-y1rjgbui 272 66 RNA rna NN cord-289926-y1rjgbui 272 67 - - HYPH cord-289926-y1rjgbui 272 68 binding bind VBG cord-289926-y1rjgbui 272 69 peptides peptide NNS cord-289926-y1rjgbui 272 70 Expression expression NN cord-289926-y1rjgbui 272 71 of of IN cord-289926-y1rjgbui 272 72 the the DT cord-289926-y1rjgbui 272 73 c c NNP cord-289926-y1rjgbui 272 74 - - HYPH cord-289926-y1rjgbui 272 75 myc myc NNP cord-289926-y1rjgbui 272 76 protooncogene protooncogene NNP cord-289926-y1rjgbui 272 77 product product NN cord-289926-y1rjgbui 272 78 in in IN cord-289926-y1rjgbui 272 79 cells cell NNS cord-289926-y1rjgbui 272 80 infected infect VBN cord-289926-y1rjgbui 272 81 with with IN cord-289926-y1rjgbui 272 82 hepatitis hepatitis NN cord-289926-y1rjgbui 272 83 delta delta NNP cord-289926-y1rjgbui 272 84 virus virus NN cord-289926-y1rjgbui 272 85 Immunogenic immunogenic JJ cord-289926-y1rjgbui 272 86 domains domain NNS cord-289926-y1rjgbui 272 87 of of IN cord-289926-y1rjgbui 272 88 hepatitis hepatitis NN cord-289926-y1rjgbui 272 89 delta delta NNP cord-289926-y1rjgbui 272 90 virus virus NN cord-289926-y1rjgbui 272 91 antigen antigen NN cord-289926-y1rjgbui 272 92 : : : cord-289926-y1rjgbui 272 93 peptide peptide NN cord-289926-y1rjgbui 272 94 mapping mapping NN cord-289926-y1rjgbui 272 95 of of IN cord-289926-y1rjgbui 272 96 epitopes epitope NNS cord-289926-y1rjgbui 272 97 recognized recognize VBN cord-289926-y1rjgbui 272 98 by by IN cord-289926-y1rjgbui 272 99 human human JJ cord-289926-y1rjgbui 272 100 and and CC cord-289926-y1rjgbui 272 101 woodchuck woodchuck NN cord-289926-y1rjgbui 272 102 antibodies antibody NNS cord-289926-y1rjgbui 272 103 Structural structural JJ cord-289926-y1rjgbui 272 104 and and CC cord-289926-y1rjgbui 272 105 functional functional JJ cord-289926-y1rjgbui 272 106 properties property NNS cord-289926-y1rjgbui 272 107 of of IN cord-289926-y1rjgbui 272 108 the the DT cord-289926-y1rjgbui 272 109 evolutionary evolutionary JJ cord-289926-y1rjgbui 272 110 ancient ancient JJ cord-289926-y1rjgbui 272 111 Y Y NNP cord-289926-y1rjgbui 272 112 - - HYPH cord-289926-y1rjgbui 272 113 box box NN cord-289926-y1rjgbui 272 114 family family NN cord-289926-y1rjgbui 272 115 of of IN cord-289926-y1rjgbui 272 116 nucleic nucleic JJ cord-289926-y1rjgbui 272 117 acid acid NN cord-289926-y1rjgbui 272 118 binding bind VBG cord-289926-y1rjgbui 272 119 proteins protein NNS cord-289926-y1rjgbui 272 120 Characterization characterization NN cord-289926-y1rjgbui 272 121 of of IN cord-289926-y1rjgbui 272 122 nuclear nuclear JJ cord-289926-y1rjgbui 272 123 targeting targeting NN cord-289926-y1rjgbui 272 124 signal signal NN cord-289926-y1rjgbui 272 125 of of IN cord-289926-y1rjgbui 272 126 hepatitis hepatitis NNP cord-289926-y1rjgbui 272 127 delta delta NNP cord-289926-y1rjgbui 272 128 antigen antigen NNP cord-289926-y1rjgbui 272 129 : : : cord-289926-y1rjgbui 272 130 nuclear nuclear JJ cord-289926-y1rjgbui 272 131 transport transport NN cord-289926-y1rjgbui 272 132 as as IN cord-289926-y1rjgbui 272 133 a a DT cord-289926-y1rjgbui 272 134 protein protein NN cord-289926-y1rjgbui 272 135 complex complex NN cord-289926-y1rjgbui 273 1 The the DT cord-289926-y1rjgbui 273 2 RNA RNA NNP cord-289926-y1rjgbui 273 3 binding binding NN cord-289926-y1rjgbui 273 4 domain domain NN cord-289926-y1rjgbui 273 5 of of IN cord-289926-y1rjgbui 273 6 ribosomal ribosomal JJ cord-289926-y1rjgbui 273 7 protein protein NN cord-289926-y1rjgbui 273 8 L11 L11 NNP cord-289926-y1rjgbui 273 9 is be VBZ cord-289926-y1rjgbui 273 10 structurally structurally RB cord-289926-y1rjgbui 273 11 similar similar JJ cord-289926-y1rjgbui 273 12 to to IN cord-289926-y1rjgbui 273 13 homeodomains homeodomains NNP cord-289926-y1rjgbui 273 14 Transcription Transcription NNP cord-289926-y1rjgbui 273 15 of of IN cord-289926-y1rjgbui 273 16 circular circular JJ cord-289926-y1rjgbui 273 17 and and CC cord-289926-y1rjgbui 273 18 noncircular noncircular JJ cord-289926-y1rjgbui 273 19 forms form NNS cord-289926-y1rjgbui 273 20 of of IN cord-289926-y1rjgbui 273 21 SRY SRY NNP cord-289926-y1rjgbui 273 22 in in IN cord-289926-y1rjgbui 273 23 mouse mouse NN cord-289926-y1rjgbui 273 24 testes testis NNS cord-289926-y1rjgbui 274 1 We -PRON- PRP cord-289926-y1rjgbui 274 2 are be VBP cord-289926-y1rjgbui 274 3 grateful grateful JJ cord-289926-y1rjgbui 274 4 to to IN cord-289926-y1rjgbui 274 5 D. D. NNP cord-289926-y1rjgbui 274 6 W. W. NNP cord-289926-y1rjgbui 274 7 Smith Smith NNP cord-289926-y1rjgbui 274 8 and and CC cord-289926-y1rjgbui 274 9 T. T. NNP cord-289926-y1rjgbui 274 10 L. L. NNP cord-289926-y1rjgbui 274 11 Bailey Bailey NNP cord-289926-y1rjgbui 274 12 for for IN cord-289926-y1rjgbui 274 13 suggestions suggestion NNS cord-289926-y1rjgbui 274 14 and and CC cord-289926-y1rjgbui 274 15 critical critical JJ cord-289926-y1rjgbui 274 16 reading reading NN cord-289926-y1rjgbui 274 17 of of IN cord-289926-y1rjgbui 274 18 the the DT cord-289926-y1rjgbui 274 19 manuscript manuscript NN cord-289926-y1rjgbui 274 20 . . . cord-289926-y1rjgbui 275 1 This this DT cord-289926-y1rjgbui 275 2 work work NN cord-289926-y1rjgbui 275 3 was be VBD cord-289926-y1rjgbui 275 4 supported support VBN cord-289926-y1rjgbui 275 5 by by IN cord-289926-y1rjgbui 276 1 NIH NIH NNP cord-289926-y1rjgbui 276 2 / / SYM cord-289926-y1rjgbui 276 3 NCRR NCRR NNP cord-289926-y1rjgbui 276 4 grant grant NN cord-289926-y1rjgbui 276 5 RR08605 rr08605 IN cord-289926-y1rjgbui 276 6 and and CC cord-289926-y1rjgbui 276 7 by by IN cord-289926-y1rjgbui 276 8 NSF NSF NNP cord-289926-y1rjgbui 276 9 grant grant VBP cord-289926-y1rjgbui 276 10 ASC-890285 ASC-890285 NNP cord-289926-y1rjgbui 276 11 . . . cord-289926-y1rjgbui 277 1 Received receive VBN cord-289926-y1rjgbui 277 2 June June NNP cord-289926-y1rjgbui 277 3 16 16 CD cord-289926-y1rjgbui 277 4 , , , cord-289926-y1rjgbui 277 5 1998 1998 CD cord-289926-y1rjgbui 277 6 _SP