id sid tid token lemma pos cord-316525-uadfehr6 1 1 key key JJ cord-316525-uadfehr6 1 2 : : : cord-316525-uadfehr6 1 3 cord-316525-uadfehr6 cord-316525-uadfehr6 NNP cord-316525-uadfehr6 1 4 authors author NNS cord-316525-uadfehr6 1 5 : : : cord-316525-uadfehr6 1 6 Zhang Zhang NNP cord-316525-uadfehr6 1 7 , , , cord-316525-uadfehr6 1 8 X. X. NNP cord-316525-uadfehr6 1 9 W. W. NNP cord-316525-uadfehr6 1 10 ; ; : cord-316525-uadfehr6 1 11 Yap Yap NNP cord-316525-uadfehr6 1 12 , , , cord-316525-uadfehr6 1 13 Y. Y. NNP cord-316525-uadfehr6 1 14 L. L. NNP cord-316525-uadfehr6 1 15 ; ; : cord-316525-uadfehr6 1 16 Danchin Danchin NNP cord-316525-uadfehr6 1 17 , , , cord-316525-uadfehr6 1 18 A. a. NN cord-316525-uadfehr6 1 19 title title NN cord-316525-uadfehr6 1 20 : : : cord-316525-uadfehr6 2 1 Testing test VBG cord-316525-uadfehr6 2 2 the the DT cord-316525-uadfehr6 2 3 hypothesis hypothesis NN cord-316525-uadfehr6 2 4 of of IN cord-316525-uadfehr6 2 5 a a DT cord-316525-uadfehr6 2 6 recombinant recombinant JJ cord-316525-uadfehr6 2 7 origin origin NN cord-316525-uadfehr6 2 8 of of IN cord-316525-uadfehr6 2 9 the the DT cord-316525-uadfehr6 2 10 SARS SARS NNP cord-316525-uadfehr6 2 11 - - HYPH cord-316525-uadfehr6 2 12 associated associate VBN cord-316525-uadfehr6 2 13 coronavirus coronavirus NN cord-316525-uadfehr6 2 14 date date NN cord-316525-uadfehr6 3 1 : : : cord-316525-uadfehr6 3 2 2004 2004 CD cord-316525-uadfehr6 3 3 - - SYM cord-316525-uadfehr6 3 4 10 10 CD cord-316525-uadfehr6 3 5 - - SYM cord-316525-uadfehr6 3 6 11 11 CD cord-316525-uadfehr6 3 7 journal journal NN cord-316525-uadfehr6 3 8 : : : cord-316525-uadfehr6 4 1 Arch Arch NNP cord-316525-uadfehr6 4 2 Virol Virol NNP cord-316525-uadfehr6 5 1 DOI DOI NNP cord-316525-uadfehr6 5 2 : : : cord-316525-uadfehr6 5 3 10.1007 10.1007 CD cord-316525-uadfehr6 5 4 / / SYM cord-316525-uadfehr6 5 5 s00705 s00705 CD cord-316525-uadfehr6 5 6 - - HYPH cord-316525-uadfehr6 5 7 004 004 CD cord-316525-uadfehr6 5 8 - - HYPH cord-316525-uadfehr6 5 9 0413 0413 CD cord-316525-uadfehr6 5 10 - - SYM cord-316525-uadfehr6 5 11 9 9 CD cord-316525-uadfehr6 5 12 sha sha NN cord-316525-uadfehr6 5 13 : : : cord-316525-uadfehr6 6 1 389e155ca041826b82fd8079d545386856110a1b 389e155ca041826b82fd8079d545386856110a1b CD cord-316525-uadfehr6 6 2 doc_id doc_id CD cord-316525-uadfehr6 6 3 : : : cord-316525-uadfehr6 6 4 316525 316525 CD cord-316525-uadfehr6 6 5 cord_uid cord_uid NN cord-316525-uadfehr6 6 6 : : : cord-316525-uadfehr6 7 1 uadfehr6 uadfehr6 JJ cord-316525-uadfehr6 8 1 The the DT cord-316525-uadfehr6 8 2 origin origin NN cord-316525-uadfehr6 8 3 of of IN cord-316525-uadfehr6 8 4 severe severe JJ cord-316525-uadfehr6 8 5 acute acute JJ cord-316525-uadfehr6 8 6 respiratory respiratory JJ cord-316525-uadfehr6 8 7 syndrome syndrome NN cord-316525-uadfehr6 8 8 - - HYPH cord-316525-uadfehr6 8 9 associated associate VBN cord-316525-uadfehr6 8 10 corona corona NN cord-316525-uadfehr6 8 11 - - HYPH cord-316525-uadfehr6 8 12 virus virus NN cord-316525-uadfehr6 8 13 ( ( -LRB- cord-316525-uadfehr6 8 14 SARS SARS NNP cord-316525-uadfehr6 8 15 - - HYPH cord-316525-uadfehr6 8 16 CoV CoV NNP cord-316525-uadfehr6 8 17 ) ) -RRB- cord-316525-uadfehr6 8 18 is be VBZ cord-316525-uadfehr6 8 19 still still RB cord-316525-uadfehr6 8 20 a a DT cord-316525-uadfehr6 8 21 matter matter NN cord-316525-uadfehr6 8 22 of of IN cord-316525-uadfehr6 8 23 speculation speculation NN cord-316525-uadfehr6 8 24 , , , cord-316525-uadfehr6 8 25 although although IN cord-316525-uadfehr6 8 26 more more JJR cord-316525-uadfehr6 8 27 than than IN cord-316525-uadfehr6 8 28 one one CD cord-316525-uadfehr6 8 29 year year NN cord-316525-uadfehr6 8 30 has have VBZ cord-316525-uadfehr6 8 31 passed pass VBN cord-316525-uadfehr6 8 32 since since IN cord-316525-uadfehr6 8 33 the the DT cord-316525-uadfehr6 8 34 onset onset NN cord-316525-uadfehr6 8 35 of of IN cord-316525-uadfehr6 8 36 the the DT cord-316525-uadfehr6 8 37 SARS SARS NNP cord-316525-uadfehr6 8 38 outbreak outbreak NN cord-316525-uadfehr6 8 39 . . . cord-316525-uadfehr6 9 1 In in IN cord-316525-uadfehr6 9 2 this this DT cord-316525-uadfehr6 9 3 study study NN cord-316525-uadfehr6 9 4 , , , cord-316525-uadfehr6 9 5 we -PRON- PRP cord-316525-uadfehr6 9 6 implemented implement VBD cord-316525-uadfehr6 9 7 a a DT cord-316525-uadfehr6 9 8 3-step 3-step JJ cord-316525-uadfehr6 9 9 strategy strategy NN cord-316525-uadfehr6 9 10 to to TO cord-316525-uadfehr6 9 11 test test VB cord-316525-uadfehr6 9 12 the the DT cord-316525-uadfehr6 9 13 intriguing intriguing JJ cord-316525-uadfehr6 9 14 hypothesis hypothesis NN cord-316525-uadfehr6 9 15 that that IN cord-316525-uadfehr6 9 16 SARS SARS NNP cord-316525-uadfehr6 9 17 - - HYPH cord-316525-uadfehr6 9 18 CoV CoV NNP cord-316525-uadfehr6 9 19 might may MD cord-316525-uadfehr6 9 20 have have VB cord-316525-uadfehr6 9 21 been be VBN cord-316525-uadfehr6 9 22 derived derive VBN cord-316525-uadfehr6 9 23 from from IN cord-316525-uadfehr6 9 24 a a DT cord-316525-uadfehr6 9 25 recombinant recombinant JJ cord-316525-uadfehr6 9 26 virus virus NN cord-316525-uadfehr6 9 27 . . . cord-316525-uadfehr6 10 1 First first RB cord-316525-uadfehr6 10 2 , , , cord-316525-uadfehr6 10 3 we -PRON- PRP cord-316525-uadfehr6 10 4 blasted blast VBD cord-316525-uadfehr6 10 5 the the DT cord-316525-uadfehr6 10 6 whole whole JJ cord-316525-uadfehr6 10 7 SARS SARS NNP cord-316525-uadfehr6 10 8 - - HYPH cord-316525-uadfehr6 10 9 CoV CoV NNP cord-316525-uadfehr6 10 10 genome genome NN cord-316525-uadfehr6 10 11 against against IN cord-316525-uadfehr6 10 12 a a DT cord-316525-uadfehr6 10 13 virus virus NN cord-316525-uadfehr6 10 14 database database NN cord-316525-uadfehr6 10 15 to to TO cord-316525-uadfehr6 10 16 search search VB cord-316525-uadfehr6 10 17 viruses virus NNS cord-316525-uadfehr6 10 18 of of IN cord-316525-uadfehr6 10 19 interest interest NN cord-316525-uadfehr6 10 20 . . . cord-316525-uadfehr6 11 1 Second second RB cord-316525-uadfehr6 11 2 , , , cord-316525-uadfehr6 11 3 we -PRON- PRP cord-316525-uadfehr6 11 4 employed employ VBD cord-316525-uadfehr6 11 5 7 7 CD cord-316525-uadfehr6 11 6 recombination recombination NN cord-316525-uadfehr6 11 7 detection detection NN cord-316525-uadfehr6 11 8 techniques technique NNS cord-316525-uadfehr6 11 9 well well RB cord-316525-uadfehr6 11 10 documented document VBN cord-316525-uadfehr6 11 11 in in IN cord-316525-uadfehr6 11 12 successfully successfully RB cord-316525-uadfehr6 11 13 detecting detect VBG cord-316525-uadfehr6 11 14 recombination recombination NN cord-316525-uadfehr6 11 15 events event NNS cord-316525-uadfehr6 11 16 to to TO cord-316525-uadfehr6 11 17 explore explore VB cord-316525-uadfehr6 11 18 the the DT cord-316525-uadfehr6 11 19 presence presence NN cord-316525-uadfehr6 11 20 of of IN cord-316525-uadfehr6 11 21 recombination recombination NN cord-316525-uadfehr6 11 22 in in IN cord-316525-uadfehr6 11 23 SARS SARS NNP cord-316525-uadfehr6 11 24 - - HYPH cord-316525-uadfehr6 11 25 CoV CoV NNP cord-316525-uadfehr6 11 26 genome genome NN cord-316525-uadfehr6 11 27 . . . cord-316525-uadfehr6 12 1 Finally finally RB cord-316525-uadfehr6 12 2 , , , cord-316525-uadfehr6 12 3 we -PRON- PRP cord-316525-uadfehr6 12 4 conducted conduct VBD cord-316525-uadfehr6 12 5 phylogenetic phylogenetic JJ cord-316525-uadfehr6 12 6 analyses analysis NNS cord-316525-uadfehr6 12 7 to to TO cord-316525-uadfehr6 12 8 further further RB cord-316525-uadfehr6 12 9 explore explore VB cord-316525-uadfehr6 12 10 whether whether IN cord-316525-uadfehr6 12 11 recombination recombination NN cord-316525-uadfehr6 12 12 has have VBZ cord-316525-uadfehr6 12 13 indeed indeed RB cord-316525-uadfehr6 12 14 occurred occur VBN cord-316525-uadfehr6 12 15 in in IN cord-316525-uadfehr6 12 16 the the DT cord-316525-uadfehr6 12 17 course course NN cord-316525-uadfehr6 12 18 of of IN cord-316525-uadfehr6 12 19 coronaviruses coronaviruse NNS cord-316525-uadfehr6 12 20 history history NN cord-316525-uadfehr6 12 21 predating predate VBG cord-316525-uadfehr6 12 22 the the DT cord-316525-uadfehr6 12 23 emergence emergence NN cord-316525-uadfehr6 12 24 of of IN cord-316525-uadfehr6 12 25 SARS SARS NNP cord-316525-uadfehr6 12 26 - - HYPH cord-316525-uadfehr6 12 27 CoV. CoV. NNP cord-316525-uadfehr6 13 1 Surprisingly surprisingly RB cord-316525-uadfehr6 13 2 , , , cord-316525-uadfehr6 13 3 we -PRON- PRP cord-316525-uadfehr6 13 4 found find VBD cord-316525-uadfehr6 13 5 that that IN cord-316525-uadfehr6 13 6 7 7 CD cord-316525-uadfehr6 13 7 putative putative JJ cord-316525-uadfehr6 13 8 recombination recombination NN cord-316525-uadfehr6 13 9 regions region NNS cord-316525-uadfehr6 13 10 , , , cord-316525-uadfehr6 13 11 located locate VBN cord-316525-uadfehr6 13 12 in in IN cord-316525-uadfehr6 13 13 Replicase Replicase NNP cord-316525-uadfehr6 13 14 1ab 1ab NN cord-316525-uadfehr6 13 15 and and CC cord-316525-uadfehr6 13 16 Spike Spike NNP cord-316525-uadfehr6 13 17 protein protein NN cord-316525-uadfehr6 13 18 , , , cord-316525-uadfehr6 13 19 exist exist VBP cord-316525-uadfehr6 13 20 between between IN cord-316525-uadfehr6 13 21 SARS SARS NNP cord-316525-uadfehr6 13 22 - - HYPH cord-316525-uadfehr6 13 23 CoV CoV NNP cord-316525-uadfehr6 13 24 and and CC cord-316525-uadfehr6 13 25 other other JJ cord-316525-uadfehr6 13 26 6 6 CD cord-316525-uadfehr6 13 27 coronaviruses coronaviruse NNS cord-316525-uadfehr6 13 28 : : : cord-316525-uadfehr6 13 29 porcine porcine JJ cord-316525-uadfehr6 13 30 epidemic epidemic NN cord-316525-uadfehr6 13 31 diarrhea diarrhea NN cord-316525-uadfehr6 13 32 virus virus NN cord-316525-uadfehr6 13 33 ( ( -LRB- cord-316525-uadfehr6 13 34 PEDV PEDV NNP cord-316525-uadfehr6 13 35 ) ) -RRB- cord-316525-uadfehr6 13 36 , , , cord-316525-uadfehr6 13 37 transmissible transmissible JJ cord-316525-uadfehr6 13 38 gastroenteritis gastroenteritis NN cord-316525-uadfehr6 13 39 virus virus NN cord-316525-uadfehr6 13 40 ( ( -LRB- cord-316525-uadfehr6 13 41 TGEV TGEV NNP cord-316525-uadfehr6 13 42 ) ) -RRB- cord-316525-uadfehr6 13 43 , , , cord-316525-uadfehr6 13 44 bovine bovine JJ cord-316525-uadfehr6 13 45 coronavirus coronavirus NN cord-316525-uadfehr6 13 46 ( ( -LRB- cord-316525-uadfehr6 13 47 BCoV BCoV NNP cord-316525-uadfehr6 13 48 ) ) -RRB- cord-316525-uadfehr6 13 49 , , , cord-316525-uadfehr6 13 50 human human JJ cord-316525-uadfehr6 13 51 coronavirus coronavirus NN cord-316525-uadfehr6 13 52 229E 229e CD cord-316525-uadfehr6 13 53 ( ( -LRB- cord-316525-uadfehr6 13 54 HCoV HCoV NNP cord-316525-uadfehr6 13 55 ) ) -RRB- cord-316525-uadfehr6 13 56 , , , cord-316525-uadfehr6 13 57 murine murine JJ cord-316525-uadfehr6 13 58 hepatitis hepatitis NN cord-316525-uadfehr6 13 59 virus virus NN cord-316525-uadfehr6 13 60 ( ( -LRB- cord-316525-uadfehr6 13 61 MHV MHV NNP cord-316525-uadfehr6 13 62 ) ) -RRB- cord-316525-uadfehr6 13 63 , , , cord-316525-uadfehr6 13 64 and and CC cord-316525-uadfehr6 13 65 avian avian JJ cord-316525-uadfehr6 13 66 infectious infectious JJ cord-316525-uadfehr6 13 67 bronchitis bronchitis NN cord-316525-uadfehr6 13 68 virus virus NN cord-316525-uadfehr6 13 69 ( ( -LRB- cord-316525-uadfehr6 13 70 IBV IBV NNP cord-316525-uadfehr6 13 71 ) ) -RRB- cord-316525-uadfehr6 13 72 . . . cord-316525-uadfehr6 14 1 Thus thus RB cord-316525-uadfehr6 14 2 , , , cord-316525-uadfehr6 14 3 our -PRON- PRP$ cord-316525-uadfehr6 14 4 analyses analysis NNS cord-316525-uadfehr6 14 5 substantiate substantiate VBP cord-316525-uadfehr6 14 6 the the DT cord-316525-uadfehr6 14 7 presence presence NN cord-316525-uadfehr6 14 8 of of IN cord-316525-uadfehr6 14 9 recombination recombination NN cord-316525-uadfehr6 14 10 events event NNS cord-316525-uadfehr6 14 11 in in IN cord-316525-uadfehr6 14 12 history history NN cord-316525-uadfehr6 14 13 that that WDT cord-316525-uadfehr6 14 14 led lead VBD cord-316525-uadfehr6 14 15 to to IN cord-316525-uadfehr6 14 16 the the DT cord-316525-uadfehr6 14 17 SARS SARS NNP cord-316525-uadfehr6 14 18 - - HYPH cord-316525-uadfehr6 14 19 CoV CoV NNP cord-316525-uadfehr6 14 20 genome genome NN cord-316525-uadfehr6 14 21 . . . cord-316525-uadfehr6 15 1 Like like IN cord-316525-uadfehr6 15 2 the the DT cord-316525-uadfehr6 15 3 other other JJ cord-316525-uadfehr6 15 4 coronaviruses coronaviruse NNS cord-316525-uadfehr6 15 5 used use VBN cord-316525-uadfehr6 15 6 in in IN cord-316525-uadfehr6 15 7 the the DT cord-316525-uadfehr6 15 8 analysis analysis NN cord-316525-uadfehr6 15 9 , , , cord-316525-uadfehr6 15 10 SARS SARS NNP cord-316525-uadfehr6 15 11 - - HYPH cord-316525-uadfehr6 15 12 CoV CoV NNP cord-316525-uadfehr6 15 13 is be VBZ cord-316525-uadfehr6 15 14 also also RB cord-316525-uadfehr6 15 15 a a DT cord-316525-uadfehr6 15 16 mosaic mosaic JJ cord-316525-uadfehr6 15 17 structure structure NN cord-316525-uadfehr6 15 18 . . . cord-316525-uadfehr6 16 1 SARS SARS NNP cord-316525-uadfehr6 16 2 , , , cord-316525-uadfehr6 16 3 a a DT cord-316525-uadfehr6 16 4 new new JJ cord-316525-uadfehr6 16 5 disease disease NN cord-316525-uadfehr6 16 6 characterized characterize VBN cord-316525-uadfehr6 16 7 by by IN cord-316525-uadfehr6 16 8 high high JJ cord-316525-uadfehr6 16 9 fever fever NN cord-316525-uadfehr6 16 10 , , , cord-316525-uadfehr6 16 11 malaise malaise NN cord-316525-uadfehr6 16 12 , , , cord-316525-uadfehr6 16 13 rigor rigor NN cord-316525-uadfehr6 16 14 , , , cord-316525-uadfehr6 16 15 headache headache NN cord-316525-uadfehr6 16 16 and and CC cord-316525-uadfehr6 16 17 non non JJ cord-316525-uadfehr6 16 18 - - JJ cord-316525-uadfehr6 16 19 productive productive JJ cord-316525-uadfehr6 16 20 cough cough NN cord-316525-uadfehr6 16 21 , , , cord-316525-uadfehr6 16 22 has have VBZ cord-316525-uadfehr6 16 23 spread spread VBN cord-316525-uadfehr6 16 24 to to IN cord-316525-uadfehr6 16 25 over over IN cord-316525-uadfehr6 16 26 30 30 CD cord-316525-uadfehr6 16 27 countries country NNS cord-316525-uadfehr6 16 28 with with IN cord-316525-uadfehr6 16 29 around around IN cord-316525-uadfehr6 16 30 8 8 CD cord-316525-uadfehr6 16 31 % % NN cord-316525-uadfehr6 16 32 of of IN cord-316525-uadfehr6 16 33 mortality mortality NN cord-316525-uadfehr6 16 34 rate rate NN cord-316525-uadfehr6 16 35 on on IN cord-316525-uadfehr6 16 36 average average JJ cord-316525-uadfehr6 16 37 . . . cord-316525-uadfehr6 17 1 Sequence sequence NN cord-316525-uadfehr6 17 2 analysis analysis NN cord-316525-uadfehr6 17 3 of of IN cord-316525-uadfehr6 17 4 SARS SARS NNP cord-316525-uadfehr6 17 5 coronavirus coronavirus NN cord-316525-uadfehr6 17 6 ( ( -LRB- cord-316525-uadfehr6 17 7 SARS SARS NNP cord-316525-uadfehr6 17 8 - - HYPH cord-316525-uadfehr6 17 9 CoV CoV NNP cord-316525-uadfehr6 17 10 ) ) -RRB- cord-316525-uadfehr6 17 11 [ [ -LRB- cord-316525-uadfehr6 17 12 17 17 CD cord-316525-uadfehr6 17 13 , , , cord-316525-uadfehr6 17 14 25 25 CD cord-316525-uadfehr6 17 15 ] ] -RRB- cord-316525-uadfehr6 17 16 showed show VBD cord-316525-uadfehr6 17 17 that that IN cord-316525-uadfehr6 17 18 it -PRON- PRP cord-316525-uadfehr6 17 19 is be VBZ cord-316525-uadfehr6 17 20 a a DT cord-316525-uadfehr6 17 21 novel novel JJ cord-316525-uadfehr6 17 22 coronavirus coronavirus NN cord-316525-uadfehr6 17 23 [ [ -LRB- cord-316525-uadfehr6 17 24 12 12 CD cord-316525-uadfehr6 17 25 ] ] -RRB- cord-316525-uadfehr6 17 26 . . . cord-316525-uadfehr6 18 1 Anand Anand NNP cord-316525-uadfehr6 18 2 et et NNP cord-316525-uadfehr6 18 3 al al NNP cord-316525-uadfehr6 18 4 . . . cord-316525-uadfehr6 19 1 [ [ -LRB- cord-316525-uadfehr6 19 2 1 1 CD cord-316525-uadfehr6 19 3 ] ] -RRB- cord-316525-uadfehr6 19 4 reported report VBD cord-316525-uadfehr6 19 5 a a DT cord-316525-uadfehr6 19 6 three three CD cord-316525-uadfehr6 19 7 - - HYPH cord-316525-uadfehr6 19 8 dimensional dimensional JJ cord-316525-uadfehr6 19 9 model model NN cord-316525-uadfehr6 19 10 of of IN cord-316525-uadfehr6 19 11 SARS SARS NNP cord-316525-uadfehr6 19 12 - - HYPH cord-316525-uadfehr6 19 13 CoV CoV NNP cord-316525-uadfehr6 19 14 main main JJ cord-316525-uadfehr6 19 15 proteinase proteinase NN cord-316525-uadfehr6 19 16 and and CC cord-316525-uadfehr6 19 17 suggested suggest VBD cord-316525-uadfehr6 19 18 that that IN cord-316525-uadfehr6 19 19 _SP cord-316525-uadfehr6 19 20 There there EX cord-316525-uadfehr6 19 21 are be VBP cord-316525-uadfehr6 19 22 a a DT cord-316525-uadfehr6 19 23 number number NN cord-316525-uadfehr6 19 24 of of IN cord-316525-uadfehr6 19 25 methods method NNS cord-316525-uadfehr6 19 26 and and CC cord-316525-uadfehr6 19 27 software software NN cord-316525-uadfehr6 19 28 packages package NNS cord-316525-uadfehr6 19 29 that that WDT cord-316525-uadfehr6 19 30 have have VBP cord-316525-uadfehr6 19 31 been be VBN cord-316525-uadfehr6 19 32 developed develop VBN cord-316525-uadfehr6 19 33 for for IN cord-316525-uadfehr6 19 34 detection detection NN cord-316525-uadfehr6 19 35 of of IN cord-316525-uadfehr6 19 36 recombination recombination NN cord-316525-uadfehr6 19 37 events event NNS cord-316525-uadfehr6 19 38 in in IN cord-316525-uadfehr6 19 39 DNA dna NN cord-316525-uadfehr6 19 40 sequences sequence NNS cord-316525-uadfehr6 19 41 . . . cord-316525-uadfehr6 20 1 The the DT cord-316525-uadfehr6 20 2 performance performance NN cord-316525-uadfehr6 20 3 of of IN cord-316525-uadfehr6 20 4 these these DT cord-316525-uadfehr6 20 5 methods method NNS cord-316525-uadfehr6 20 6 has have VBZ cord-316525-uadfehr6 20 7 been be VBN cord-316525-uadfehr6 20 8 extensively extensively RB cord-316525-uadfehr6 20 9 evaluated evaluate VBN cord-316525-uadfehr6 20 10 and and CC cord-316525-uadfehr6 20 11 compared compare VBN cord-316525-uadfehr6 20 12 on on IN cord-316525-uadfehr6 20 13 simulated simulated JJ cord-316525-uadfehr6 20 14 and and CC cord-316525-uadfehr6 20 15 real real JJ cord-316525-uadfehr6 20 16 data datum NNS cord-316525-uadfehr6 20 17 [ [ -LRB- cord-316525-uadfehr6 20 18 23 23 CD cord-316525-uadfehr6 20 19 , , , cord-316525-uadfehr6 20 20 24 24 CD cord-316525-uadfehr6 20 21 ] ] -RRB- cord-316525-uadfehr6 20 22 . . . cord-316525-uadfehr6 21 1 In in IN cord-316525-uadfehr6 21 2 the the DT cord-316525-uadfehr6 21 3 present present JJ cord-316525-uadfehr6 21 4 study study NN cord-316525-uadfehr6 21 5 we -PRON- PRP cord-316525-uadfehr6 21 6 applied apply VBD cord-316525-uadfehr6 21 7 these these DT cord-316525-uadfehr6 21 8 methods method NNS cord-316525-uadfehr6 21 9 to to IN cord-316525-uadfehr6 21 10 RNA RNA NNP cord-316525-uadfehr6 21 11 viruses virus NNS cord-316525-uadfehr6 21 12 . . . cord-316525-uadfehr6 22 1 SARS SARS NNP cord-316525-uadfehr6 22 2 - - HYPH cord-316525-uadfehr6 22 3 CoV CoV NNP cord-316525-uadfehr6 22 4 and and CC cord-316525-uadfehr6 22 5 other other JJ cord-316525-uadfehr6 22 6 6 6 CD cord-316525-uadfehr6 22 7 coronavirus coronavirus NN cord-316525-uadfehr6 22 8 genomes genome NNS cord-316525-uadfehr6 22 9 ( ( -LRB- cord-316525-uadfehr6 22 10 SARS SARS NNP cord-316525-uadfehr6 22 11 - - HYPH cord-316525-uadfehr6 22 12 CoV CoV NNP cord-316525-uadfehr6 22 13 , , , cord-316525-uadfehr6 22 14 IBV IBV NNP cord-316525-uadfehr6 22 15 , , , cord-316525-uadfehr6 22 16 BCoV BCoV NNP cord-316525-uadfehr6 22 17 , , , cord-316525-uadfehr6 22 18 HCoV HCoV NNP cord-316525-uadfehr6 22 19 , , , cord-316525-uadfehr6 22 20 MHV MHV NNP cord-316525-uadfehr6 22 21 , , , cord-316525-uadfehr6 22 22 PEDV PEDV NNP cord-316525-uadfehr6 22 23 , , , cord-316525-uadfehr6 22 24 TGEV TGEV NNP cord-316525-uadfehr6 22 25 ) ) -RRB- cord-316525-uadfehr6 22 26 were be VBD cord-316525-uadfehr6 22 27 first first RB cord-316525-uadfehr6 22 28 aligned align VBN cord-316525-uadfehr6 22 29 using use VBG cord-316525-uadfehr6 22 30 CLUSTALW CLUSTALW NNP cord-316525-uadfehr6 22 31 [ [ -LRB- cord-316525-uadfehr6 22 32 33 33 CD cord-316525-uadfehr6 22 33 ] ] -RRB- cord-316525-uadfehr6 22 34 . . . cord-316525-uadfehr6 23 1 Sites site NNS cord-316525-uadfehr6 23 2 with with IN cord-316525-uadfehr6 23 3 gaps gap NNS cord-316525-uadfehr6 23 4 were be VBD cord-316525-uadfehr6 23 5 removed remove VBN cord-316525-uadfehr6 23 6 and and CC cord-316525-uadfehr6 23 7 a a DT cord-316525-uadfehr6 23 8 25077-nt 25077-nt JJ cord-316525-uadfehr6 23 9 alignment alignment NN cord-316525-uadfehr6 23 10 was be VBD cord-316525-uadfehr6 23 11 generated generate VBN cord-316525-uadfehr6 23 12 . . . cord-316525-uadfehr6 24 1 Subsequently subsequently RB cord-316525-uadfehr6 24 2 , , , cord-316525-uadfehr6 24 3 seven seven CD cord-316525-uadfehr6 24 4 methods method NNS cord-316525-uadfehr6 24 5 were be VBD cord-316525-uadfehr6 24 6 employed employ VBN cord-316525-uadfehr6 24 7 to to TO cord-316525-uadfehr6 24 8 detect detect VB cord-316525-uadfehr6 24 9 the the DT cord-316525-uadfehr6 24 10 occurrence occurrence NN cord-316525-uadfehr6 24 11 of of IN cord-316525-uadfehr6 24 12 recombination recombination NN cord-316525-uadfehr6 24 13 ( ( -LRB- cord-316525-uadfehr6 24 14 see see VB cord-316525-uadfehr6 24 15 corresponding corresponding JJ cord-316525-uadfehr6 24 16 reference reference NN cord-316525-uadfehr6 24 17 in in IN cord-316525-uadfehr6 24 18 parenthesis parenthesis NN cord-316525-uadfehr6 24 19 for for IN cord-316525-uadfehr6 24 20 details detail NNS cord-316525-uadfehr6 24 21 of of IN cord-316525-uadfehr6 24 22 each each DT cord-316525-uadfehr6 24 23 method method NN cord-316525-uadfehr6 24 24 ) ) -RRB- cord-316525-uadfehr6 25 1 : : : cord-316525-uadfehr6 25 2 BOOTSCAN BOOTSCAN NNP cord-316525-uadfehr6 25 3 [ [ -LRB- cord-316525-uadfehr6 25 4 26 26 CD cord-316525-uadfehr6 25 5 ] ] -RRB- cord-316525-uadfehr6 25 6 , , , cord-316525-uadfehr6 25 7 GENECONV GENECONV NNP cord-316525-uadfehr6 25 8 [ [ -LRB- cord-316525-uadfehr6 25 9 28 28 CD cord-316525-uadfehr6 25 10 ] ] -RRB- cord-316525-uadfehr6 25 11 , , , cord-316525-uadfehr6 25 12 DSS DSS NNP cord-316525-uadfehr6 25 13 ( ( -LRB- cord-316525-uadfehr6 25 14 Difference difference NN cord-316525-uadfehr6 25 15 of of IN cord-316525-uadfehr6 25 16 Sums Sums NNPS cord-316525-uadfehr6 25 17 of of IN cord-316525-uadfehr6 25 18 Squares square NNS cord-316525-uadfehr6 25 19 ) ) -RRB- cord-316525-uadfehr6 25 20 [ [ -LRB- cord-316525-uadfehr6 25 21 20 20 CD cord-316525-uadfehr6 25 22 ] ] -RRB- cord-316525-uadfehr6 25 23 , , . cord-316525-uadfehr6 26 1 HMM hmm UH cord-316525-uadfehr6 27 1 ( ( -LRB- cord-316525-uadfehr6 27 2 Hidden hidden JJ cord-316525-uadfehr6 27 3 Markov Markov NNP cord-316525-uadfehr6 27 4 Model Model NNP cord-316525-uadfehr6 27 5 ) ) -RRB- cord-316525-uadfehr6 28 1 [ [ -LRB- cord-316525-uadfehr6 28 2 8 8 CD cord-316525-uadfehr6 28 3 ] ] -RRB- cord-316525-uadfehr6 28 4 , , , cord-316525-uadfehr6 28 5 MAXCHI MAXCHI NNP cord-316525-uadfehr6 29 1 ( ( -LRB- cord-316525-uadfehr6 29 2 Maximum Maximum NNP cord-316525-uadfehr6 29 3 Chi Chi NNP cord-316525-uadfehr6 29 4 - - HYPH cord-316525-uadfehr6 29 5 Square Square NNP cord-316525-uadfehr6 29 6 method method NN cord-316525-uadfehr6 29 7 ) ) -RRB- cord-316525-uadfehr6 29 8 [ [ -LRB- cord-316525-uadfehr6 29 9 19 19 CD cord-316525-uadfehr6 29 10 ] ] -RRB- cord-316525-uadfehr6 29 11 , , , cord-316525-uadfehr6 29 12 PDM PDM NNP cord-316525-uadfehr6 29 13 ( ( -LRB- cord-316525-uadfehr6 29 14 Probabilistic Probabilistic NNP cord-316525-uadfehr6 29 15 Divergence Divergence NNP cord-316525-uadfehr6 29 16 Measures Measures NNPS cord-316525-uadfehr6 29 17 ) ) -RRB- cord-316525-uadfehr6 29 18 [ [ -LRB- cord-316525-uadfehr6 29 19 9 9 CD cord-316525-uadfehr6 29 20 ] ] -RRB- cord-316525-uadfehr6 29 21 , , , cord-316525-uadfehr6 29 22 RDP RDP NNP cord-316525-uadfehr6 29 23 ( ( -LRB- cord-316525-uadfehr6 29 24 Recombination Recombination NNP cord-316525-uadfehr6 29 25 Detection Detection NNP cord-316525-uadfehr6 29 26 Program Program NNP cord-316525-uadfehr6 29 27 ) ) -RRB- cord-316525-uadfehr6 30 1 [ [ -LRB- cord-316525-uadfehr6 30 2 18 18 CD cord-316525-uadfehr6 30 3 ] ] -RRB- cord-316525-uadfehr6 30 4 . . . cord-316525-uadfehr6 31 1 BOOTSCAN BOOTSCAN NNP cord-316525-uadfehr6 31 2 , , , cord-316525-uadfehr6 31 3 MAXCHI MAXCHI NNP cord-316525-uadfehr6 31 4 and and CC cord-316525-uadfehr6 31 5 RDP RDP NNP cord-316525-uadfehr6 31 6 are be VBP cord-316525-uadfehr6 31 7 implemented implement VBN cord-316525-uadfehr6 31 8 in in IN cord-316525-uadfehr6 31 9 RDP RDP NNP cord-316525-uadfehr6 31 10 software software NN cord-316525-uadfehr6 31 11 package package NN cord-316525-uadfehr6 31 12 , , , cord-316525-uadfehr6 31 13 http://web.uct.ac.za/depts/microbiology/microdescription.htm http://web.uct.ac.za/depts/microbiology/microdescription.htm ADD cord-316525-uadfehr6 31 14 . . . cord-316525-uadfehr6 32 1 GENECONV GENECONV NNP cord-316525-uadfehr6 32 2 is be VBZ cord-316525-uadfehr6 32 3 implemented implement VBN cord-316525-uadfehr6 32 4 in in IN cord-316525-uadfehr6 32 5 the the DT cord-316525-uadfehr6 32 6 program program NN cord-316525-uadfehr6 32 7 , , , cord-316525-uadfehr6 32 8 http://www.math.wustl.edu/∼sawyer/geneconv/. http://www.math.wustl.edu/∼sawyer/geneconv/. NNP cord-316525-uadfehr6 32 9 DSS DSS NNP cord-316525-uadfehr6 32 10 , , , cord-316525-uadfehr6 32 11 HMM HMM NNP cord-316525-uadfehr6 32 12 and and CC cord-316525-uadfehr6 32 13 PDM PDM NNP cord-316525-uadfehr6 32 14 are be VBP cord-316525-uadfehr6 32 15 implemented implement VBN cord-316525-uadfehr6 32 16 in in IN cord-316525-uadfehr6 32 17 TOPALi TOPALi NNP cord-316525-uadfehr6 32 18 software software NN cord-316525-uadfehr6 32 19 package package NN cord-316525-uadfehr6 32 20 , , , cord-316525-uadfehr6 32 21 http://www.bioss.sari.ac.uk/software.html http://www.bioss.sari.ac.uk/software.html '' cord-316525-uadfehr6 32 22 . . . cord-316525-uadfehr6 33 1 Basically basically RB cord-316525-uadfehr6 33 2 default default NN cord-316525-uadfehr6 33 3 parameter parameter NN cord-316525-uadfehr6 33 4 settings setting NNS cord-316525-uadfehr6 33 5 were be VBD cord-316525-uadfehr6 33 6 used use VBN cord-316525-uadfehr6 33 7 in in IN cord-316525-uadfehr6 33 8 all all PDT cord-316525-uadfehr6 33 9 the the DT cord-316525-uadfehr6 33 10 programs program NNS cord-316525-uadfehr6 33 11 , , , cord-316525-uadfehr6 33 12 except except IN cord-316525-uadfehr6 33 13 the the DT cord-316525-uadfehr6 33 14 following follow VBG cord-316525-uadfehr6 33 15 values value NNS cord-316525-uadfehr6 33 16 : : : cord-316525-uadfehr6 33 17 gscale gscale NN cord-316525-uadfehr6 33 18 = = SYM cord-316525-uadfehr6 33 19 1 1 CD cord-316525-uadfehr6 33 20 ( ( -LRB- cord-316525-uadfehr6 33 21 GENECONV GENECONV NNP cord-316525-uadfehr6 33 22 ) ) -RRB- cord-316525-uadfehr6 33 23 , , , cord-316525-uadfehr6 33 24 internal internal JJ cord-316525-uadfehr6 33 25 and and CC cord-316525-uadfehr6 33 26 external external JJ cord-316525-uadfehr6 33 27 references reference NNS cord-316525-uadfehr6 33 28 ( ( -LRB- cord-316525-uadfehr6 33 29 RDP RDP NNP cord-316525-uadfehr6 33 30 ) ) -RRB- cord-316525-uadfehr6 33 31 , , , cord-316525-uadfehr6 33 32 window window NN cord-316525-uadfehr6 33 33 size size NN cord-316525-uadfehr6 33 34 = = SYM cord-316525-uadfehr6 33 35 300 300 CD cord-316525-uadfehr6 33 36 and and CC cord-316525-uadfehr6 33 37 step step NN cord-316525-uadfehr6 33 38 = = SYM cord-316525-uadfehr6 33 39 10 10 CD cord-316525-uadfehr6 33 40 ( ( -LRB- cord-316525-uadfehr6 33 41 DSS DSS NNP cord-316525-uadfehr6 33 42 , , , cord-316525-uadfehr6 33 43 HMM HMM NNP cord-316525-uadfehr6 33 44 and and CC cord-316525-uadfehr6 33 45 PDM PDM NNP cord-316525-uadfehr6 33 46 ) ) -RRB- cord-316525-uadfehr6 33 47 . . . cord-316525-uadfehr6 34 1 After after IN cord-316525-uadfehr6 34 2 potential potential JJ cord-316525-uadfehr6 34 3 recombination recombination NN cord-316525-uadfehr6 34 4 events event NNS cord-316525-uadfehr6 34 5 were be VBD cord-316525-uadfehr6 34 6 identified identify VBN cord-316525-uadfehr6 34 7 by by IN cord-316525-uadfehr6 34 8 at at RB cord-316525-uadfehr6 34 9 least least JJS cord-316525-uadfehr6 34 10 3 3 CD cord-316525-uadfehr6 34 11 methods method NNS cord-316525-uadfehr6 34 12 above above RB cord-316525-uadfehr6 34 13 , , , cord-316525-uadfehr6 34 14 separate separate JJ cord-316525-uadfehr6 34 15 neighbor neighbor NN cord-316525-uadfehr6 34 16 joining join VBG cord-316525-uadfehr6 34 17 trees tree NNS cord-316525-uadfehr6 34 18 were be VBD cord-316525-uadfehr6 34 19 constructed construct VBN cord-316525-uadfehr6 34 20 for for IN cord-316525-uadfehr6 34 21 each each DT cord-316525-uadfehr6 34 22 putative putative JJ cord-316525-uadfehr6 34 23 recombination recombination NN cord-316525-uadfehr6 34 24 region region NN cord-316525-uadfehr6 34 25 to to TO cord-316525-uadfehr6 34 26 better better RB cord-316525-uadfehr6 34 27 evaluate evaluate VB cord-316525-uadfehr6 34 28 the the DT cord-316525-uadfehr6 34 29 evidence evidence NN cord-316525-uadfehr6 34 30 for for IN cord-316525-uadfehr6 34 31 conflicting conflict VBG cord-316525-uadfehr6 34 32 evolutionary evolutionary JJ cord-316525-uadfehr6 34 33 histories history NNS cord-316525-uadfehr6 34 34 of of IN cord-316525-uadfehr6 34 35 different different JJ cord-316525-uadfehr6 34 36 sequence sequence NN cord-316525-uadfehr6 34 37 regions region NNS cord-316525-uadfehr6 34 38 . . . cord-316525-uadfehr6 35 1 All all DT cord-316525-uadfehr6 35 2 trees tree NNS cord-316525-uadfehr6 35 3 were be VBD cord-316525-uadfehr6 35 4 produced produce VBN cord-316525-uadfehr6 35 5 with with IN cord-316525-uadfehr6 35 6 TOPALi TOPALi NNS cord-316525-uadfehr6 35 7 mentioned mention VBN cord-316525-uadfehr6 35 8 above above RB cord-316525-uadfehr6 35 9 . . . cord-316525-uadfehr6 36 1 Table table NN cord-316525-uadfehr6 36 2 2 2 CD cord-316525-uadfehr6 36 3 summarizes summarize VBZ cord-316525-uadfehr6 36 4 the the DT cord-316525-uadfehr6 36 5 results result NNS cord-316525-uadfehr6 36 6 of of IN cord-316525-uadfehr6 36 7 BOOTSCAN BOOTSCAN NNP cord-316525-uadfehr6 36 8 analysis analysis NN cord-316525-uadfehr6 36 9 with with IN cord-316525-uadfehr6 36 10 100 100 CD cord-316525-uadfehr6 36 11 % % NN cord-316525-uadfehr6 36 12 bootstrap bootstrap NN cord-316525-uadfehr6 36 13 support support NN cord-316525-uadfehr6 36 14 and and CC cord-316525-uadfehr6 36 15 significant significant JJ cord-316525-uadfehr6 36 16 P p NN cord-316525-uadfehr6 36 17 - - HYPH cord-316525-uadfehr6 36 18 value value NN cord-316525-uadfehr6 36 19 ( ( -LRB- cord-316525-uadfehr6 36 20 < < XX cord-316525-uadfehr6 36 21 0.05 0.05 CD cord-316525-uadfehr6 36 22 for for IN cord-316525-uadfehr6 36 23 uncorrected uncorrected JJ cord-316525-uadfehr6 36 24 and and CC cord-316525-uadfehr6 36 25 MC MC NNP cord-316525-uadfehr6 36 26 corrected correct VBD cord-316525-uadfehr6 36 27 Pvalue Pvalue NNP cord-316525-uadfehr6 36 28 ) ) -RRB- cord-316525-uadfehr6 36 29 . . . cord-316525-uadfehr6 37 1 Two two CD cord-316525-uadfehr6 37 2 regions region NNS cord-316525-uadfehr6 37 3 ( ( -LRB- cord-316525-uadfehr6 37 4 13151 13151 CD cord-316525-uadfehr6 37 5 - - SYM cord-316525-uadfehr6 37 6 13299 13299 CD cord-316525-uadfehr6 37 7 and and CC cord-316525-uadfehr6 37 8 16051 16051 CD cord-316525-uadfehr6 37 9 - - SYM cord-316525-uadfehr6 37 10 16449 16449 CD cord-316525-uadfehr6 37 11 , , , cord-316525-uadfehr6 37 12 position position NN cord-316525-uadfehr6 37 13 in in IN cord-316525-uadfehr6 37 14 alignment alignment NN cord-316525-uadfehr6 37 15 ) ) -RRB- cord-316525-uadfehr6 37 16 are be VBP cord-316525-uadfehr6 37 17 identified identify VBN cord-316525-uadfehr6 37 18 as as IN cord-316525-uadfehr6 37 19 putative putative JJ cord-316525-uadfehr6 37 20 recombination recombination NN cord-316525-uadfehr6 37 21 regions region NNS cord-316525-uadfehr6 37 22 and and CC cord-316525-uadfehr6 37 23 all all DT cord-316525-uadfehr6 37 24 6 6 CD cord-316525-uadfehr6 37 25 coronaviruses coronaviruse NNS cord-316525-uadfehr6 37 26 are be VBP cord-316525-uadfehr6 37 27 potential potential JJ cord-316525-uadfehr6 37 28 parents parent NNS cord-316525-uadfehr6 37 29 with with IN cord-316525-uadfehr6 37 30 SARS SARS NNP cord-316525-uadfehr6 37 31 - - HYPH cord-316525-uadfehr6 37 32 CoV CoV NNP cord-316525-uadfehr6 37 33 as as IN cord-316525-uadfehr6 37 34 potential potential JJ cord-316525-uadfehr6 37 35 daughter daughter NN cord-316525-uadfehr6 37 36 . . . cord-316525-uadfehr6 38 1 GENECONV GENECONV NNP cord-316525-uadfehr6 38 2 detected detect VBD cord-316525-uadfehr6 38 3 9 9 CD cord-316525-uadfehr6 38 4 putative putative JJ cord-316525-uadfehr6 38 5 recombination recombination NN cord-316525-uadfehr6 38 6 events event NNS cord-316525-uadfehr6 38 7 occurred occur VBD cord-316525-uadfehr6 38 8 in in IN cord-316525-uadfehr6 38 9 a a DT cord-316525-uadfehr6 38 10 wide wide JJ cord-316525-uadfehr6 38 11 range range NN cord-316525-uadfehr6 38 12 of of IN cord-316525-uadfehr6 38 13 positions position NNS cord-316525-uadfehr6 38 14 5941 5941 CD cord-316525-uadfehr6 38 15 - - SYM cord-316525-uadfehr6 38 16 24997 24997 CD cord-316525-uadfehr6 38 17 ( ( -LRB- cord-316525-uadfehr6 38 18 in in IN cord-316525-uadfehr6 38 19 alignment alignment NN cord-316525-uadfehr6 38 20 ) ) -RRB- cord-316525-uadfehr6 38 21 at at IN cord-316525-uadfehr6 38 22 a a DT cord-316525-uadfehr6 38 23 significant significant JJ cord-316525-uadfehr6 38 24 level level NN cord-316525-uadfehr6 38 25 p p NN cord-316525-uadfehr6 38 26 < < XX cord-316525-uadfehr6 38 27 0.05 0.05 CD cord-316525-uadfehr6 38 28 for for IN cord-316525-uadfehr6 38 29 two two CD cord-316525-uadfehr6 38 30 P p NN cord-316525-uadfehr6 38 31 - - HYPH cord-316525-uadfehr6 38 32 values value NNS cord-316525-uadfehr6 38 33 : : : cord-316525-uadfehr6 38 34 simulated simulate VBN cord-316525-uadfehr6 38 35 P p NN cord-316525-uadfehr6 38 36 - - HYPH cord-316525-uadfehr6 38 37 value value NN cord-316525-uadfehr6 38 38 ( ( -LRB- cord-316525-uadfehr6 38 39 based base VBN cord-316525-uadfehr6 38 40 on on IN cord-316525-uadfehr6 38 41 10,000 10,000 CD cord-316525-uadfehr6 38 42 permutations permutation NNS cord-316525-uadfehr6 38 43 ) ) -RRB- cord-316525-uadfehr6 38 44 and and CC cord-316525-uadfehr6 38 45 BLASTlike blastlike JJ cord-316525-uadfehr6 38 46 BC BC NNP cord-316525-uadfehr6 38 47 KA KA NNP cord-316525-uadfehr6 38 48 P p NN cord-316525-uadfehr6 38 49 - - HYPH cord-316525-uadfehr6 38 50 value value NN cord-316525-uadfehr6 38 51 ( ( -LRB- cord-316525-uadfehr6 38 52 Table Table NNP cord-316525-uadfehr6 38 53 3 3 CD cord-316525-uadfehr6 38 54 ) ) -RRB- cord-316525-uadfehr6 38 55 . . . cord-316525-uadfehr6 39 1 All all DT cord-316525-uadfehr6 39 2 6 6 CD cord-316525-uadfehr6 39 3 coronaviruses coronaviruse NNS cord-316525-uadfehr6 39 4 are be VBP cord-316525-uadfehr6 39 5 potential potential JJ cord-316525-uadfehr6 39 6 parents parent NNS cord-316525-uadfehr6 39 7 with with IN cord-316525-uadfehr6 39 8 SARS SARS NNP cord-316525-uadfehr6 39 9 - - HYPH cord-316525-uadfehr6 39 10 CoV CoV NNP cord-316525-uadfehr6 39 11 as as IN cord-316525-uadfehr6 39 12 potential potential JJ cord-316525-uadfehr6 39 13 daughter daughter NN cord-316525-uadfehr6 39 14 . . . cord-316525-uadfehr6 40 1 MAXCHI MAXCHI NNP cord-316525-uadfehr6 40 2 identified identify VBD cord-316525-uadfehr6 40 3 15 15 CD cord-316525-uadfehr6 40 4 putative putative JJ cord-316525-uadfehr6 40 5 recombination recombination NN cord-316525-uadfehr6 40 6 events event NNS cord-316525-uadfehr6 40 7 ( ( -LRB- cord-316525-uadfehr6 40 8 Table table NN cord-316525-uadfehr6 40 9 4 4 CD cord-316525-uadfehr6 40 10 , , , cord-316525-uadfehr6 40 11 possible possible JJ cord-316525-uadfehr6 40 12 misidentification misidentification NN cord-316525-uadfehr6 40 13 events event NNS cord-316525-uadfehr6 40 14 are be VBP cord-316525-uadfehr6 40 15 not not RB cord-316525-uadfehr6 40 16 retained retain VBN cord-316525-uadfehr6 40 17 ) ) -RRB- cord-316525-uadfehr6 40 18 . . . cord-316525-uadfehr6 41 1 Most Most JJS cord-316525-uadfehr6 41 2 of of IN cord-316525-uadfehr6 41 3 the the DT cord-316525-uadfehr6 41 4 breakpoints breakpoint NNS cord-316525-uadfehr6 41 5 are be VBP cord-316525-uadfehr6 41 6 significant significant JJ cord-316525-uadfehr6 41 7 at at IN cord-316525-uadfehr6 41 8 about about IN cord-316525-uadfehr6 41 9 0.001 0.001 CD cord-316525-uadfehr6 41 10 level level NN cord-316525-uadfehr6 41 11 ; ; : cord-316525-uadfehr6 41 12 the the DT cord-316525-uadfehr6 41 13 position position NN cord-316525-uadfehr6 41 14 located locate VBN cord-316525-uadfehr6 41 15 in in IN cord-316525-uadfehr6 41 16 alignment alignment NN cord-316525-uadfehr6 41 17 spans span VBZ cord-316525-uadfehr6 41 18 from from IN cord-316525-uadfehr6 41 19 3534 3534 CD cord-316525-uadfehr6 41 20 to to IN cord-316525-uadfehr6 41 21 22840 22840 CD cord-316525-uadfehr6 41 22 , , , cord-316525-uadfehr6 41 23 but but CC cord-316525-uadfehr6 41 24 some some DT cord-316525-uadfehr6 41 25 beginning beginning NN cord-316525-uadfehr6 41 26 or or CC cord-316525-uadfehr6 41 27 ending end VBG cord-316525-uadfehr6 41 28 breakpoints breakpoint NNS cord-316525-uadfehr6 41 29 are be VBP cord-316525-uadfehr6 41 30 not not RB cord-316525-uadfehr6 41 31 determined determine VBN cord-316525-uadfehr6 41 32 . . . cord-316525-uadfehr6 42 1 Similarly similarly RB cord-316525-uadfehr6 42 2 , , , cord-316525-uadfehr6 42 3 6 6 CD cord-316525-uadfehr6 42 4 coronaviruses coronaviruse NNS cord-316525-uadfehr6 42 5 are be VBP cord-316525-uadfehr6 42 6 potential potential JJ cord-316525-uadfehr6 42 7 parents parent NNS cord-316525-uadfehr6 42 8 with with IN cord-316525-uadfehr6 42 9 SARS SARS NNP cord-316525-uadfehr6 42 10 - - HYPH cord-316525-uadfehr6 42 11 CoV CoV NNP cord-316525-uadfehr6 42 12 as as IN cord-316525-uadfehr6 42 13 potential potential JJ cord-316525-uadfehr6 42 14 daughter daughter NN cord-316525-uadfehr6 42 15 . . . cord-316525-uadfehr6 43 1 RDP RDP NNP cord-316525-uadfehr6 43 2 revealed reveal VBD cord-316525-uadfehr6 43 3 that that IN cord-316525-uadfehr6 43 4 6 6 CD cord-316525-uadfehr6 43 5 putative putative JJ cord-316525-uadfehr6 43 6 recombination recombination NN cord-316525-uadfehr6 43 7 events event NNS cord-316525-uadfehr6 43 8 occur occur VBP cord-316525-uadfehr6 43 9 in in IN cord-316525-uadfehr6 43 10 the the DT cord-316525-uadfehr6 43 11 domain domain NN cord-316525-uadfehr6 43 12 of of IN cord-316525-uadfehr6 43 13 alignment alignment NN cord-316525-uadfehr6 43 14 5910 5910 CD cord-316525-uadfehr6 43 15 - - SYM cord-316525-uadfehr6 43 16 13334 13334 CD cord-316525-uadfehr6 43 17 ( ( -LRB- cord-316525-uadfehr6 43 18 Table table NN cord-316525-uadfehr6 43 19 5 5 CD cord-316525-uadfehr6 43 20 ) ) -RRB- cord-316525-uadfehr6 43 21 , , , cord-316525-uadfehr6 43 22 with with IN cord-316525-uadfehr6 43 23 the the DT cord-316525-uadfehr6 43 24 uncorrected uncorrected JJ cord-316525-uadfehr6 43 25 and and CC cord-316525-uadfehr6 43 26 MC MC NNP cord-316525-uadfehr6 43 27 corrected correct VBD cord-316525-uadfehr6 43 28 pvalue pvalue NNS cord-316525-uadfehr6 43 29 at at IN cord-316525-uadfehr6 43 30 less less JJR cord-316525-uadfehr6 43 31 than than IN cord-316525-uadfehr6 43 32 0.002 0.002 CD cord-316525-uadfehr6 43 33 and and CC cord-316525-uadfehr6 43 34 0.05 0.05 CD cord-316525-uadfehr6 43 35 respectively respectively RB cord-316525-uadfehr6 43 36 . . . cord-316525-uadfehr6 44 1 In in IN cord-316525-uadfehr6 44 2 this this DT cord-316525-uadfehr6 44 3 case case NN cord-316525-uadfehr6 44 4 , , , cord-316525-uadfehr6 44 5 4 4 CD cord-316525-uadfehr6 44 6 coronaviruses coronaviruse NNS cord-316525-uadfehr6 44 7 ( ( -LRB- cord-316525-uadfehr6 44 8 IBV IBV NNP cord-316525-uadfehr6 44 9 , , , cord-316525-uadfehr6 44 10 BCoV BCoV NNP cord-316525-uadfehr6 44 11 , , , cord-316525-uadfehr6 44 12 MHV MHV NNP cord-316525-uadfehr6 44 13 and and CC cord-316525-uadfehr6 44 14 PEDV PEDV NNP cord-316525-uadfehr6 44 15 ) ) -RRB- cord-316525-uadfehr6 44 16 are be VBP cord-316525-uadfehr6 44 17 potential potential JJ cord-316525-uadfehr6 44 18 parents parent NNS cord-316525-uadfehr6 44 19 with with IN cord-316525-uadfehr6 44 20 SARS SARS NNP cord-316525-uadfehr6 44 21 - - HYPH cord-316525-uadfehr6 44 22 CoV CoV NNP cord-316525-uadfehr6 44 23 as as IN cord-316525-uadfehr6 44 24 potential potential JJ cord-316525-uadfehr6 44 25 daughter daughter NN cord-316525-uadfehr6 44 26 . . . cord-316525-uadfehr6 45 1 Figure figure NN cord-316525-uadfehr6 45 2 1 1 CD cord-316525-uadfehr6 45 3 shows show VBZ cord-316525-uadfehr6 45 4 the the DT cord-316525-uadfehr6 45 5 DSS DSS NNP cord-316525-uadfehr6 45 6 profiles profile NNS cord-316525-uadfehr6 45 7 of of IN cord-316525-uadfehr6 45 8 putative putative JJ cord-316525-uadfehr6 45 9 breakpoints breakpoint NNS cord-316525-uadfehr6 45 10 between between IN cord-316525-uadfehr6 45 11 SARS SARS NNP cord-316525-uadfehr6 45 12 - - HYPH cord-316525-uadfehr6 45 13 CoV CoV NNP cord-316525-uadfehr6 45 14 and and CC cord-316525-uadfehr6 45 15 other other JJ cord-316525-uadfehr6 45 16 coronaviruses coronaviruse NNS cord-316525-uadfehr6 46 1 ( ( -LRB- cord-316525-uadfehr6 46 2 Dotted dotted JJ cord-316525-uadfehr6 46 3 line line NN cord-316525-uadfehr6 46 4 indicates indicate VBZ cord-316525-uadfehr6 46 5 the the DT cord-316525-uadfehr6 46 6 95 95 CD cord-316525-uadfehr6 46 7 percentile percentile NN cord-316525-uadfehr6 46 8 under under IN cord-316525-uadfehr6 46 9 the the DT cord-316525-uadfehr6 46 10 null null JJ cord-316525-uadfehr6 46 11 hypothesis hypothesis NN cord-316525-uadfehr6 46 12 of of IN cord-316525-uadfehr6 46 13 no no DT cord-316525-uadfehr6 46 14 recombination recombination NN cord-316525-uadfehr6 46 15 ) ) -RRB- cord-316525-uadfehr6 46 16 : : : cord-316525-uadfehr6 47 1 SARS SARS NNP cord-316525-uadfehr6 47 2 - - HYPH cord-316525-uadfehr6 47 3 CoV CoV NNP cord-316525-uadfehr6 47 4 , , , cord-316525-uadfehr6 47 5 IBV IBV NNP cord-316525-uadfehr6 47 6 , , , cord-316525-uadfehr6 47 7 BCoV BCoV NNP cord-316525-uadfehr6 47 8 and and CC cord-316525-uadfehr6 47 9 MHV MHV NNP cord-316525-uadfehr6 47 10 ( ( -LRB- cord-316525-uadfehr6 47 11 Fig Fig NNP cord-316525-uadfehr6 47 12 . . . cord-316525-uadfehr6 47 13 1a 1a CD cord-316525-uadfehr6 47 14 ) ) -RRB- cord-316525-uadfehr6 47 15 , , , cord-316525-uadfehr6 47 16 SARS SARS NNP cord-316525-uadfehr6 47 17 - - HYPH cord-316525-uadfehr6 47 18 CoV CoV NNP cord-316525-uadfehr6 47 19 , , , cord-316525-uadfehr6 47 20 MHV MHV NNP cord-316525-uadfehr6 47 21 , , , cord-316525-uadfehr6 47 22 PEDV PEDV NNP cord-316525-uadfehr6 47 23 and and CC cord-316525-uadfehr6 47 24 TGEV TGEV NNP cord-316525-uadfehr6 47 25 ( ( -LRB- cord-316525-uadfehr6 47 26 Fig fig NN cord-316525-uadfehr6 47 27 . . . cord-316525-uadfehr6 47 28 1b 1b CD cord-316525-uadfehr6 47 29 ) ) -RRB- cord-316525-uadfehr6 47 30 , , , cord-316525-uadfehr6 47 31 SARS SARS NNP cord-316525-uadfehr6 47 32 - - HYPH cord-316525-uadfehr6 47 33 CoV CoV NNP cord-316525-uadfehr6 47 34 , , , cord-316525-uadfehr6 47 35 IBV IBV NNP cord-316525-uadfehr6 47 36 , , , cord-316525-uadfehr6 47 37 HCoV HCoV NNP cord-316525-uadfehr6 47 38 and and CC cord-316525-uadfehr6 47 39 TGEV TGEV NNP cord-316525-uadfehr6 47 40 ( ( -LRB- cord-316525-uadfehr6 47 41 Fig Fig NNP cord-316525-uadfehr6 47 42 . . . cord-316525-uadfehr6 47 43 1c 1c CD cord-316525-uadfehr6 47 44 ) ) -RRB- cord-316525-uadfehr6 47 45 . . . cord-316525-uadfehr6 48 1 There there EX cord-316525-uadfehr6 48 2 are be VBP cord-316525-uadfehr6 48 3 about about RB cord-316525-uadfehr6 48 4 6 6 CD cord-316525-uadfehr6 48 5 different different JJ cord-316525-uadfehr6 48 6 breakpoints breakpoint NNS cord-316525-uadfehr6 48 7 ( ( -LRB- cord-316525-uadfehr6 48 8 significant significant JJ cord-316525-uadfehr6 48 9 peaks peak NNS cord-316525-uadfehr6 48 10 ) ) -RRB- cord-316525-uadfehr6 48 11 : : : cord-316525-uadfehr6 48 12 13614 13614 CD cord-316525-uadfehr6 48 13 and and CC cord-316525-uadfehr6 48 14 16085 16085 CD cord-316525-uadfehr6 48 15 ( ( -LRB- cord-316525-uadfehr6 48 16 Fig Fig NNP cord-316525-uadfehr6 48 17 . . . cord-316525-uadfehr6 48 18 1a 1a CD cord-316525-uadfehr6 48 19 ) ) -RRB- cord-316525-uadfehr6 48 20 , , , cord-316525-uadfehr6 48 21 11008 11008 CD cord-316525-uadfehr6 48 22 and and CC cord-316525-uadfehr6 48 23 12850 12850 CD cord-316525-uadfehr6 48 24 ( ( -LRB- cord-316525-uadfehr6 48 25 Fig Fig NNP cord-316525-uadfehr6 48 26 . . . cord-316525-uadfehr6 48 27 1b 1b CD cord-316525-uadfehr6 48 28 ) ) -RRB- cord-316525-uadfehr6 48 29 , , , cord-316525-uadfehr6 48 30 12805 12805 CD cord-316525-uadfehr6 48 31 , , , cord-316525-uadfehr6 48 32 13614 13614 CD cord-316525-uadfehr6 48 33 and and CC cord-316525-uadfehr6 48 34 16444 16444 CD cord-316525-uadfehr6 48 35 ( ( -LRB- cord-316525-uadfehr6 48 36 Fig Fig NNP cord-316525-uadfehr6 48 37 . . . cord-316525-uadfehr6 48 38 1c 1c CD cord-316525-uadfehr6 48 39 ) ) -RRB- cord-316525-uadfehr6 48 40 . . . cord-316525-uadfehr6 49 1 HMM HMM NNP cord-316525-uadfehr6 49 2 plots plot NNS cord-316525-uadfehr6 49 3 for for IN cord-316525-uadfehr6 49 4 SARS SARS NNP cord-316525-uadfehr6 49 5 - - HYPH cord-316525-uadfehr6 49 6 CoV CoV NNP cord-316525-uadfehr6 49 7 , , , cord-316525-uadfehr6 49 8 IBV IBV NNP cord-316525-uadfehr6 49 9 , , , cord-316525-uadfehr6 49 10 BCoV BCoV NNP cord-316525-uadfehr6 49 11 and and CC cord-316525-uadfehr6 49 12 HCoV HCoV NNP cord-316525-uadfehr6 49 13 ( ( -LRB- cord-316525-uadfehr6 49 14 Fig fig NN cord-316525-uadfehr6 49 15 . . NNP cord-316525-uadfehr6 49 16 2 2 LS cord-316525-uadfehr6 49 17 ) ) -RRB- cord-316525-uadfehr6 49 18 revealed reveal VBD cord-316525-uadfehr6 49 19 that that IN cord-316525-uadfehr6 49 20 the the DT cord-316525-uadfehr6 49 21 putative putative JJ cord-316525-uadfehr6 49 22 breakpoints breakpoint NNS cord-316525-uadfehr6 49 23 are be VBP cord-316525-uadfehr6 49 24 at at IN cord-316525-uadfehr6 49 25 about about IN cord-316525-uadfehr6 49 26 position position NN cord-316525-uadfehr6 49 27 5500 5500 CD cord-316525-uadfehr6 49 28 and and CC cord-316525-uadfehr6 49 29 19000 19000 CD cord-316525-uadfehr6 49 30 . . . cord-316525-uadfehr6 50 1 There there EX cord-316525-uadfehr6 50 2 is be VBZ cord-316525-uadfehr6 50 3 a a DT cord-316525-uadfehr6 50 4 clear clear JJ cord-316525-uadfehr6 50 5 transition transition NN cord-316525-uadfehr6 50 6 from from IN cord-316525-uadfehr6 50 7 state state NN cord-316525-uadfehr6 50 8 1 1 CD cord-316525-uadfehr6 51 1 ( ( -LRB- cord-316525-uadfehr6 51 2 SARS SARS NNP cord-316525-uadfehr6 51 3 - - HYPH cord-316525-uadfehr6 51 4 CoV CoV NNP cord-316525-uadfehr6 51 5 grouped group VBN cord-316525-uadfehr6 51 6 with with IN cord-316525-uadfehr6 51 7 IBV IBV NNP cord-316525-uadfehr6 51 8 ) ) -RRB- cord-316525-uadfehr6 52 1 ( ( -LRB- cord-316525-uadfehr6 52 2 Fig Fig NNP cord-316525-uadfehr6 52 3 . . . cord-316525-uadfehr6 52 4 2a 2a CD cord-316525-uadfehr6 52 5 ) ) -RRB- cord-316525-uadfehr6 52 6 into into IN cord-316525-uadfehr6 52 7 state state NN cord-316525-uadfehr6 52 8 3 3 CD cord-316525-uadfehr6 53 1 ( ( -LRB- cord-316525-uadfehr6 53 2 SARS SARS NNP cord-316525-uadfehr6 53 3 - - HYPH cord-316525-uadfehr6 53 4 CoV CoV NNP cord-316525-uadfehr6 53 5 grouped group VBD cord-316525-uadfehr6 53 6 with with IN cord-316525-uadfehr6 53 7 HCoV HCoV NNP cord-316525-uadfehr6 53 8 ) ) -RRB- cord-316525-uadfehr6 54 1 ( ( -LRB- cord-316525-uadfehr6 54 2 Fig Fig NNP cord-316525-uadfehr6 54 3 . . . cord-316525-uadfehr6 54 4 2c 2c NNP cord-316525-uadfehr6 54 5 ) ) -RRB- cord-316525-uadfehr6 54 6 . . . cord-316525-uadfehr6 55 1 The the DT cord-316525-uadfehr6 55 2 region region NN cord-316525-uadfehr6 55 3 between between IN cord-316525-uadfehr6 55 4 5500 5500 CD cord-316525-uadfehr6 55 5 and and CC cord-316525-uadfehr6 55 6 19000 19000 CD cord-316525-uadfehr6 55 7 is be VBZ cord-316525-uadfehr6 55 8 noisy noisy JJ cord-316525-uadfehr6 55 9 , , , cord-316525-uadfehr6 55 10 and and CC cord-316525-uadfehr6 55 11 at at IN cord-316525-uadfehr6 55 12 this this DT cord-316525-uadfehr6 55 13 moment moment NN cord-316525-uadfehr6 55 14 no no DT cord-316525-uadfehr6 55 15 information information NN cord-316525-uadfehr6 55 16 can can MD cord-316525-uadfehr6 55 17 be be VB cord-316525-uadfehr6 55 18 provided provide VBN cord-316525-uadfehr6 55 19 by by IN cord-316525-uadfehr6 55 20 HMM HMM NNP cord-316525-uadfehr6 55 21 . . . cord-316525-uadfehr6 56 1 Figure figure NN cord-316525-uadfehr6 56 2 3 3 CD cord-316525-uadfehr6 56 3 shows show VBZ cord-316525-uadfehr6 56 4 the the DT cord-316525-uadfehr6 56 5 results result NNS cord-316525-uadfehr6 56 6 of of IN cord-316525-uadfehr6 56 7 PDM PDM NNP cord-316525-uadfehr6 56 8 analysis analysis NN cord-316525-uadfehr6 56 9 performed perform VBN cord-316525-uadfehr6 56 10 on on IN cord-316525-uadfehr6 56 11 SARS SARS NNP cord-316525-uadfehr6 56 12 - - HYPH cord-316525-uadfehr6 56 13 CoV CoV NNP cord-316525-uadfehr6 56 14 and and CC cord-316525-uadfehr6 56 15 other other JJ cord-316525-uadfehr6 56 16 coronaviruses coronaviruse NNS cord-316525-uadfehr6 56 17 ( ( -LRB- cord-316525-uadfehr6 56 18 dotted dotted JJ cord-316525-uadfehr6 56 19 line line NN cord-316525-uadfehr6 56 20 indicates indicate VBZ cord-316525-uadfehr6 56 21 the the DT cord-316525-uadfehr6 56 22 95 95 CD cord-316525-uadfehr6 56 23 % % NN cord-316525-uadfehr6 56 24 critical critical JJ cord-316525-uadfehr6 56 25 region region NN cord-316525-uadfehr6 56 26 for for IN cord-316525-uadfehr6 56 27 the the DT cord-316525-uadfehr6 56 28 null null NN cord-316525-uadfehr6 57 1 ( ( -LRB- cord-316525-uadfehr6 57 2 Fig Fig NNP cord-316525-uadfehr6 57 3 . . . cord-316525-uadfehr6 57 4 3c 3c NNP cord-316525-uadfehr6 57 5 , , , cord-316525-uadfehr6 57 6 d d NNP cord-316525-uadfehr6 57 7 ) ) -RRB- cord-316525-uadfehr6 57 8 , , , cord-316525-uadfehr6 57 9 1393 1393 CD cord-316525-uadfehr6 57 10 , , , cord-316525-uadfehr6 57 11 6111 6111 CD cord-316525-uadfehr6 57 12 , , , cord-316525-uadfehr6 57 13 16624 16624 CD cord-316525-uadfehr6 57 14 , , , cord-316525-uadfehr6 57 15 19859 19859 CD cord-316525-uadfehr6 57 16 and and CC cord-316525-uadfehr6 57 17 20802 20802 CD cord-316525-uadfehr6 57 18 ( ( -LRB- cord-316525-uadfehr6 57 19 Fig Fig NNP cord-316525-uadfehr6 57 20 . . . cord-316525-uadfehr6 57 21 3e 3e NNP cord-316525-uadfehr6 57 22 , , , cord-316525-uadfehr6 57 23 f f NNP cord-316525-uadfehr6 57 24 ) ) -RRB- cord-316525-uadfehr6 57 25 . . . cord-316525-uadfehr6 58 1 Posada Posada NNP cord-316525-uadfehr6 58 2 [ [ -LRB- cord-316525-uadfehr6 58 3 23 23 CD cord-316525-uadfehr6 58 4 ] ] -RRB- cord-316525-uadfehr6 58 5 suggested suggest VBD cord-316525-uadfehr6 58 6 that that IN cord-316525-uadfehr6 58 7 one one PRP cord-316525-uadfehr6 58 8 should should MD cord-316525-uadfehr6 58 9 not not RB cord-316525-uadfehr6 58 10 rely rely VB cord-316525-uadfehr6 58 11 too too RB cord-316525-uadfehr6 58 12 much much RB cord-316525-uadfehr6 58 13 on on IN cord-316525-uadfehr6 58 14 a a DT cord-316525-uadfehr6 58 15 single single JJ cord-316525-uadfehr6 58 16 method method NN cord-316525-uadfehr6 58 17 for for IN cord-316525-uadfehr6 58 18 recombination recombination NN cord-316525-uadfehr6 58 19 detection detection NN cord-316525-uadfehr6 58 20 . . . cord-316525-uadfehr6 59 1 Here here RB cord-316525-uadfehr6 59 2 we -PRON- PRP cord-316525-uadfehr6 59 3 consider consider VBP cord-316525-uadfehr6 59 4 the the DT cord-316525-uadfehr6 59 5 regions region NNS cord-316525-uadfehr6 59 6 identified identify VBN cord-316525-uadfehr6 59 7 by by IN cord-316525-uadfehr6 59 8 at at RB cord-316525-uadfehr6 59 9 least least JJS cord-316525-uadfehr6 59 10 3 3 CD cord-316525-uadfehr6 59 11 methods method NNS cord-316525-uadfehr6 59 12 as as IN cord-316525-uadfehr6 59 13 putative putative JJ cord-316525-uadfehr6 59 14 recombination recombination NN cord-316525-uadfehr6 59 15 regions region NNS cord-316525-uadfehr6 59 16 . . . cord-316525-uadfehr6 60 1 The the DT cord-316525-uadfehr6 60 2 results result NNS cord-316525-uadfehr6 60 3 are be VBP cord-316525-uadfehr6 60 4 summarized summarize VBN cord-316525-uadfehr6 60 5 in in IN cord-316525-uadfehr6 60 6 Table Table NNP cord-316525-uadfehr6 60 7 6 6 CD cord-316525-uadfehr6 60 8 . . . cord-316525-uadfehr6 61 1 Seven seven CD cord-316525-uadfehr6 61 2 putative putative JJ cord-316525-uadfehr6 61 3 recombination recombination NN cord-316525-uadfehr6 61 4 regions region NNS cord-316525-uadfehr6 61 5 span span VBP cord-316525-uadfehr6 61 6 a a DT cord-316525-uadfehr6 61 7 range range NN cord-316525-uadfehr6 61 8 of of IN cord-316525-uadfehr6 61 9 positions position NNS cord-316525-uadfehr6 61 10 in in IN cord-316525-uadfehr6 61 11 SARS SARS NNP cord-316525-uadfehr6 61 12 - - HYPH cord-316525-uadfehr6 61 13 CoV CoV NNP cord-316525-uadfehr6 61 14 _SP cord-316525-uadfehr6 61 15 Phylogenetic Phylogenetic NNP cord-316525-uadfehr6 61 16 trees tree NNS cord-316525-uadfehr6 61 17 constructed construct VBN cord-316525-uadfehr6 61 18 by by IN cord-316525-uadfehr6 61 19 using use VBG cord-316525-uadfehr6 61 20 putative putative JJ cord-316525-uadfehr6 61 21 recombination recombination NN cord-316525-uadfehr6 61 22 regions region NNS cord-316525-uadfehr6 61 23 and and CC cord-316525-uadfehr6 61 24 nonrecombination nonrecombination NN cord-316525-uadfehr6 61 25 regions region NNS cord-316525-uadfehr6 61 26 identified identify VBN cord-316525-uadfehr6 61 27 by by IN cord-316525-uadfehr6 61 28 above above JJ cord-316525-uadfehr6 61 29 techniques technique NNS cord-316525-uadfehr6 61 30 are be VBP cord-316525-uadfehr6 61 31 shown show VBN cord-316525-uadfehr6 61 32 in in IN cord-316525-uadfehr6 61 33 Figure Figure NNP cord-316525-uadfehr6 61 34 4 4 CD cord-316525-uadfehr6 61 35 . . . cord-316525-uadfehr6 62 1 The the DT cord-316525-uadfehr6 62 2 left left JJ cord-316525-uadfehr6 62 3 panels panel NNS cord-316525-uadfehr6 62 4 stand stand VBP cord-316525-uadfehr6 62 5 for for IN cord-316525-uadfehr6 62 6 non non JJ cord-316525-uadfehr6 62 7 - - JJ cord-316525-uadfehr6 62 8 recombination recombination JJ cord-316525-uadfehr6 62 9 regions region NNS cord-316525-uadfehr6 62 10 and and CC cord-316525-uadfehr6 62 11 the the DT cord-316525-uadfehr6 62 12 right right JJ cord-316525-uadfehr6 62 13 panels panel NNS cord-316525-uadfehr6 62 14 for for IN cord-316525-uadfehr6 62 15 recombination recombination NN cord-316525-uadfehr6 62 16 regions region NNS cord-316525-uadfehr6 62 17 . . . cord-316525-uadfehr6 63 1 We -PRON- PRP cord-316525-uadfehr6 63 2 compared compare VBD cord-316525-uadfehr6 63 3 each each DT cord-316525-uadfehr6 63 4 row row NN cord-316525-uadfehr6 63 5 of of IN cord-316525-uadfehr6 63 6 figures figure NNS cord-316525-uadfehr6 63 7 and and CC cord-316525-uadfehr6 63 8 found find VBD cord-316525-uadfehr6 63 9 that that IN cord-316525-uadfehr6 63 10 the the DT cord-316525-uadfehr6 63 11 phylogenetic phylogenetic JJ cord-316525-uadfehr6 63 12 tree tree NN cord-316525-uadfehr6 63 13 in in IN cord-316525-uadfehr6 63 14 the the DT cord-316525-uadfehr6 63 15 left left JJ cord-316525-uadfehr6 63 16 panel panel NN cord-316525-uadfehr6 63 17 ( ( -LRB- cord-316525-uadfehr6 63 18 non non JJ cord-316525-uadfehr6 63 19 - - JJ cord-316525-uadfehr6 63 20 recombination recombination JJ cord-316525-uadfehr6 63 21 region region NN cord-316525-uadfehr6 63 22 ) ) -RRB- cord-316525-uadfehr6 63 23 had have VBD cord-316525-uadfehr6 63 24 very very RB cord-316525-uadfehr6 63 25 different different JJ cord-316525-uadfehr6 63 26 topology topology NN cord-316525-uadfehr6 63 27 when when WRB cord-316525-uadfehr6 63 28 compared compare VBN cord-316525-uadfehr6 63 29 to to IN cord-316525-uadfehr6 63 30 the the DT cord-316525-uadfehr6 63 31 phylogenetic phylogenetic JJ cord-316525-uadfehr6 63 32 tree tree NN cord-316525-uadfehr6 63 33 in in IN cord-316525-uadfehr6 63 34 the the DT cord-316525-uadfehr6 63 35 right right JJ cord-316525-uadfehr6 63 36 panel panel NN cord-316525-uadfehr6 63 37 ( ( -LRB- cord-316525-uadfehr6 63 38 recombination recombination NN cord-316525-uadfehr6 63 39 region region NN cord-316525-uadfehr6 63 40 ) ) -RRB- cord-316525-uadfehr6 63 41 , , , cord-316525-uadfehr6 63 42 which which WDT cord-316525-uadfehr6 63 43 indicates indicate VBZ cord-316525-uadfehr6 63 44 that that IN cord-316525-uadfehr6 63 45 recombination recombination NN cord-316525-uadfehr6 63 46 has have VBZ cord-316525-uadfehr6 63 47 occurred occur VBN cord-316525-uadfehr6 63 48 . . . cord-316525-uadfehr6 64 1 For for IN cord-316525-uadfehr6 64 2 example example NN cord-316525-uadfehr6 64 3 , , , cord-316525-uadfehr6 64 4 in in IN cord-316525-uadfehr6 64 5 Fig Fig NNP cord-316525-uadfehr6 64 6 . . NNP cord-316525-uadfehr6 64 7 4a 4a CD cord-316525-uadfehr6 64 8 , , , cord-316525-uadfehr6 64 9 7 7 CD cord-316525-uadfehr6 64 10 coronaviruses coronaviruse NNS cord-316525-uadfehr6 64 11 are be VBP cord-316525-uadfehr6 64 12 divided divide VBN cord-316525-uadfehr6 64 13 into into IN cord-316525-uadfehr6 64 14 4 4 CD cord-316525-uadfehr6 64 15 groups group NNS cord-316525-uadfehr6 64 16 : : : cord-316525-uadfehr6 64 17 group group NN cord-316525-uadfehr6 64 18 1 1 CD cord-316525-uadfehr6 64 19 for for IN cord-316525-uadfehr6 64 20 TGEV TGEV NNP cord-316525-uadfehr6 64 21 , , , cord-316525-uadfehr6 64 22 HCoV HCoV NNP cord-316525-uadfehr6 64 23 and and CC cord-316525-uadfehr6 64 24 PEDV PEDV NNP cord-316525-uadfehr6 64 25 , , , cord-316525-uadfehr6 64 26 group group NN cord-316525-uadfehr6 64 27 2 2 CD cord-316525-uadfehr6 64 28 for for IN cord-316525-uadfehr6 64 29 BCoV BCoV NNP cord-316525-uadfehr6 64 30 and and CC cord-316525-uadfehr6 64 31 MHV MHV NNP cord-316525-uadfehr6 64 32 , , , cord-316525-uadfehr6 64 33 group group NN cord-316525-uadfehr6 64 34 3 3 CD cord-316525-uadfehr6 64 35 for for IN cord-316525-uadfehr6 64 36 IBV IBV NNP cord-316525-uadfehr6 64 37 , , , cord-316525-uadfehr6 64 38 and and CC cord-316525-uadfehr6 64 39 group group NN cord-316525-uadfehr6 64 40 4 4 CD cord-316525-uadfehr6 64 41 for for IN cord-316525-uadfehr6 64 42 SARS SARS NNP cord-316525-uadfehr6 64 43 - - HYPH cord-316525-uadfehr6 64 44 CoV CoV NNP cord-316525-uadfehr6 64 45 , , , cord-316525-uadfehr6 64 46 consistent consistent JJ cord-316525-uadfehr6 64 47 with with IN cord-316525-uadfehr6 64 48 Marra Marra NNP cord-316525-uadfehr6 64 49 et et NNP cord-316525-uadfehr6 64 50 al al NNP cord-316525-uadfehr6 64 51 . . . cord-316525-uadfehr6 65 1 [ [ -LRB- cord-316525-uadfehr6 65 2 17 17 CD cord-316525-uadfehr6 65 3 ] ] -RRB- cord-316525-uadfehr6 65 4 ; ; : cord-316525-uadfehr6 65 5 while while IN cord-316525-uadfehr6 65 6 in in IN cord-316525-uadfehr6 65 7 Fig Fig NNP cord-316525-uadfehr6 65 8 . . . cord-316525-uadfehr6 65 9 4b 4b CD cord-316525-uadfehr6 65 10 , , , cord-316525-uadfehr6 65 11 7 7 CD cord-316525-uadfehr6 65 12 coronaviruses coronaviruse NNS cord-316525-uadfehr6 65 13 are be VBP cord-316525-uadfehr6 65 14 divided divide VBN cord-316525-uadfehr6 65 15 and and CC cord-316525-uadfehr6 65 16 SARS SARS NNP cord-316525-uadfehr6 65 17 - - HYPH cord-316525-uadfehr6 65 18 CoV CoV NNP cord-316525-uadfehr6 65 19 , , , cord-316525-uadfehr6 65 20 suggests suggest VBZ cord-316525-uadfehr6 65 21 that that IN cord-316525-uadfehr6 65 22 SARS SARS NNP cord-316525-uadfehr6 65 23 - - HYPH cord-316525-uadfehr6 65 24 CoV CoV NNP cord-316525-uadfehr6 65 25 is be VBZ cord-316525-uadfehr6 65 26 most most RBS cord-316525-uadfehr6 65 27 closely closely RB cord-316525-uadfehr6 65 28 related related JJ cord-316525-uadfehr6 65 29 to to IN cord-316525-uadfehr6 65 30 BCoV BCoV NNP cord-316525-uadfehr6 65 31 and and CC cord-316525-uadfehr6 65 32 MHV MHV NNP cord-316525-uadfehr6 65 33 , , , cord-316525-uadfehr6 65 34 which which WDT cord-316525-uadfehr6 65 35 is be VBZ cord-316525-uadfehr6 65 36 consistent consistent JJ cord-316525-uadfehr6 65 37 with with IN cord-316525-uadfehr6 65 38 a a DT cord-316525-uadfehr6 65 39 recent recent JJ cord-316525-uadfehr6 65 40 report report NN cord-316525-uadfehr6 65 41 [ [ -LRB- cord-316525-uadfehr6 65 42 29 29 CD cord-316525-uadfehr6 65 43 ] ] -RRB- cord-316525-uadfehr6 65 44 . . . cord-316525-uadfehr6 66 1 At at IN cord-316525-uadfehr6 66 2 the the DT cord-316525-uadfehr6 66 3 same same JJ cord-316525-uadfehr6 66 4 time time NN cord-316525-uadfehr6 66 5 , , , cord-316525-uadfehr6 66 6 SARS SARS NNP cord-316525-uadfehr6 66 7 - - HYPH cord-316525-uadfehr6 66 8 CoV CoV NNP cord-316525-uadfehr6 66 9 is be VBZ cord-316525-uadfehr6 66 10 also also RB cord-316525-uadfehr6 66 11 most most RBS cord-316525-uadfehr6 66 12 closely closely RB cord-316525-uadfehr6 66 13 related relate VBN cord-316525-uadfehr6 66 14 to to IN cord-316525-uadfehr6 66 15 TGEV TGEV NNP cord-316525-uadfehr6 66 16 ( ( -LRB- cord-316525-uadfehr6 66 17 Fig Fig NNP cord-316525-uadfehr6 66 18 . . . cord-316525-uadfehr6 66 19 4d 4d CD cord-316525-uadfehr6 66 20 ) ) -RRB- cord-316525-uadfehr6 66 21 and and CC cord-316525-uadfehr6 66 22 IBV IBV NNP cord-316525-uadfehr6 66 23 ( ( -LRB- cord-316525-uadfehr6 66 24 Fig Fig NNP cord-316525-uadfehr6 66 25 . . . cord-316525-uadfehr6 66 26 4f 4f CD cord-316525-uadfehr6 66 27 ) ) -RRB- cord-316525-uadfehr6 66 28 . . . cord-316525-uadfehr6 67 1 Thus thus RB cord-316525-uadfehr6 67 2 , , , cord-316525-uadfehr6 67 3 phylogenetic phylogenetic JJ cord-316525-uadfehr6 67 4 analysis analysis NN cord-316525-uadfehr6 67 5 substantiates substantiate VBZ cord-316525-uadfehr6 67 6 the the DT cord-316525-uadfehr6 67 7 presence presence NN cord-316525-uadfehr6 67 8 of of IN cord-316525-uadfehr6 67 9 recombination recombination NN cord-316525-uadfehr6 67 10 events event NNS cord-316525-uadfehr6 67 11 in in IN cord-316525-uadfehr6 67 12 the the DT cord-316525-uadfehr6 67 13 history history NN cord-316525-uadfehr6 67 14 that that WDT cord-316525-uadfehr6 67 15 led lead VBD cord-316525-uadfehr6 67 16 to to IN cord-316525-uadfehr6 67 17 the the DT cord-316525-uadfehr6 67 18 SARS SARS NNP cord-316525-uadfehr6 67 19 - - HYPH cord-316525-uadfehr6 67 20 CoV CoV NNP cord-316525-uadfehr6 67 21 genome genome NN cord-316525-uadfehr6 67 22 . . . cord-316525-uadfehr6 68 1 In in IN cord-316525-uadfehr6 68 2 this this DT cord-316525-uadfehr6 68 3 study study NN cord-316525-uadfehr6 68 4 , , , cord-316525-uadfehr6 68 5 seven seven CD cord-316525-uadfehr6 68 6 recombination recombination NN cord-316525-uadfehr6 68 7 detection detection NN cord-316525-uadfehr6 68 8 methods method NNS cord-316525-uadfehr6 68 9 and and CC cord-316525-uadfehr6 68 10 phylogenetic phylogenetic JJ cord-316525-uadfehr6 68 11 analyses analysis NNS cord-316525-uadfehr6 68 12 were be VBD cord-316525-uadfehr6 68 13 performed perform VBN cord-316525-uadfehr6 68 14 on on IN cord-316525-uadfehr6 68 15 SARS SARS NNP cord-316525-uadfehr6 68 16 - - HYPH cord-316525-uadfehr6 68 17 CoV CoV NNP cord-316525-uadfehr6 68 18 and and CC cord-316525-uadfehr6 68 19 the the DT cord-316525-uadfehr6 68 20 six six CD cord-316525-uadfehr6 68 21 coronaviruses coronaviruse NNS cord-316525-uadfehr6 68 22 identified identify VBN cord-316525-uadfehr6 68 23 by by IN cord-316525-uadfehr6 68 24 BLAST blast NN cord-316525-uadfehr6 68 25 ( ( -LRB- cord-316525-uadfehr6 68 26 IBV IBV NNP cord-316525-uadfehr6 68 27 , , , cord-316525-uadfehr6 68 28 BCoV BCoV NNP cord-316525-uadfehr6 68 29 , , , cord-316525-uadfehr6 68 30 HCoV HCoV NNP cord-316525-uadfehr6 68 31 , , , cord-316525-uadfehr6 68 32 MHV MHV NNP cord-316525-uadfehr6 68 33 , , , cord-316525-uadfehr6 68 34 PEDV PEDV NNP cord-316525-uadfehr6 68 35 and and CC cord-316525-uadfehr6 68 36 TGEV TGEV NNP cord-316525-uadfehr6 68 37 ) ) -RRB- cord-316525-uadfehr6 68 38 . . . cord-316525-uadfehr6 69 1 These these DT cord-316525-uadfehr6 69 2 techniques technique NNS cord-316525-uadfehr6 69 3 successfully successfully RB cord-316525-uadfehr6 69 4 identified identify VBD cord-316525-uadfehr6 69 5 recombination recombination NN cord-316525-uadfehr6 69 6 events event NNS cord-316525-uadfehr6 69 7 in in IN cord-316525-uadfehr6 69 8 bacteria bacteria NNS cord-316525-uadfehr6 69 9 and and CC cord-316525-uadfehr6 69 10 viruses virus NNS cord-316525-uadfehr6 69 11 [ [ -LRB- cord-316525-uadfehr6 69 12 2 2 CD cord-316525-uadfehr6 69 13 , , , cord-316525-uadfehr6 69 14 3 3 CD cord-316525-uadfehr6 69 15 , , , cord-316525-uadfehr6 69 16 6 6 CD cord-316525-uadfehr6 69 17 , , , cord-316525-uadfehr6 69 18 21 21 CD cord-316525-uadfehr6 69 19 , , , cord-316525-uadfehr6 69 20 26 26 CD cord-316525-uadfehr6 69 21 , , , cord-316525-uadfehr6 69 22 39 39 CD cord-316525-uadfehr6 69 23 ] ] -RRB- cord-316525-uadfehr6 69 24 . . . cord-316525-uadfehr6 70 1 Our -PRON- PRP$ cord-316525-uadfehr6 70 2 analysis analysis NN cord-316525-uadfehr6 70 3 concurred concur VBD cord-316525-uadfehr6 70 4 to to TO cord-316525-uadfehr6 70 5 suggest suggest VB cord-316525-uadfehr6 70 6 the the DT cord-316525-uadfehr6 70 7 occurrence occurrence NN cord-316525-uadfehr6 70 8 of of IN cord-316525-uadfehr6 70 9 recombination recombination NN cord-316525-uadfehr6 70 10 events event NNS cord-316525-uadfehr6 70 11 between between IN cord-316525-uadfehr6 70 12 ancestors ancestor NNS cord-316525-uadfehr6 70 13 of of IN cord-316525-uadfehr6 70 14 SARS SARS NNP cord-316525-uadfehr6 70 15 - - HYPH cord-316525-uadfehr6 70 16 CoV CoV NNP cord-316525-uadfehr6 70 17 and and CC cord-316525-uadfehr6 70 18 these these DT cord-316525-uadfehr6 70 19 6 6 CD cord-316525-uadfehr6 70 20 coronaviruses coronaviruse NNS cord-316525-uadfehr6 70 21 . . . cord-316525-uadfehr6 71 1 Indeed indeed RB cord-316525-uadfehr6 71 2 , , , cord-316525-uadfehr6 71 3 pairwise pairwise JJ cord-316525-uadfehr6 71 4 alignment alignment NN cord-316525-uadfehr6 71 5 showed show VBD cord-316525-uadfehr6 71 6 that that IN cord-316525-uadfehr6 71 7 many many JJ cord-316525-uadfehr6 71 8 segments segment NNS cord-316525-uadfehr6 71 9 of of IN cord-316525-uadfehr6 71 10 high high JJ cord-316525-uadfehr6 71 11 homology homology NN cord-316525-uadfehr6 71 12 with with IN cord-316525-uadfehr6 71 13 IBV IBV NNP cord-316525-uadfehr6 71 14 , , , cord-316525-uadfehr6 71 15 BCoV BCoV NNP cord-316525-uadfehr6 71 16 , , , cord-316525-uadfehr6 71 17 HCoV HCoV NNP cord-316525-uadfehr6 71 18 , , , cord-316525-uadfehr6 71 19 MHV MHV NNP cord-316525-uadfehr6 71 20 , , , cord-316525-uadfehr6 71 21 PEDV PEDV NNP cord-316525-uadfehr6 71 22 and and CC cord-316525-uadfehr6 71 23 TGEV TGEV NNP cord-316525-uadfehr6 71 24 do do VBP cord-316525-uadfehr6 71 25 exist exist VB cord-316525-uadfehr6 71 26 in in IN cord-316525-uadfehr6 71 27 SARS SARS NNP cord-316525-uadfehr6 71 28 - - HYPH cord-316525-uadfehr6 71 29 CoV CoV NNP cord-316525-uadfehr6 71 30 genome genome NN cord-316525-uadfehr6 71 31 , , , cord-316525-uadfehr6 71 32 Table Table NNP cord-316525-uadfehr6 71 33 7 7 CD cord-316525-uadfehr6 71 34 exhibits exhibit VBZ cord-316525-uadfehr6 71 35 the the DT cord-316525-uadfehr6 71 36 segments segment NNS cord-316525-uadfehr6 71 37 with with IN cord-316525-uadfehr6 71 38 length length NN cord-316525-uadfehr6 71 39 > > XX cord-316525-uadfehr6 72 1 20 20 CD cord-316525-uadfehr6 72 2 nt nt RB cord-316525-uadfehr6 72 3 and and CC cord-316525-uadfehr6 72 4 identiy identiy FW cord-316525-uadfehr6 72 5 > > XX cord-316525-uadfehr6 72 6 80 80 CD cord-316525-uadfehr6 72 7 % % NN cord-316525-uadfehr6 72 8 , , , cord-316525-uadfehr6 72 9 and and CC cord-316525-uadfehr6 72 10 Fig Fig NNP cord-316525-uadfehr6 72 11 . . . cord-316525-uadfehr6 73 1 5 5 CD cord-316525-uadfehr6 73 2 shows show VBZ cord-316525-uadfehr6 73 3 the the DT cord-316525-uadfehr6 73 4 mosaic mosaic JJ cord-316525-uadfehr6 73 5 structure structure NN cord-316525-uadfehr6 73 6 of of IN cord-316525-uadfehr6 73 7 the the DT cord-316525-uadfehr6 73 8 region region NN cord-316525-uadfehr6 73 9 14930 14930 CD cord-316525-uadfehr6 73 10 - - SYM cord-316525-uadfehr6 73 11 15908 15908 CD cord-316525-uadfehr6 73 12 in in IN cord-316525-uadfehr6 73 13 SARS SARS NNP cord-316525-uadfehr6 73 14 - - HYPH cord-316525-uadfehr6 73 15 CoV CoV NNP cord-316525-uadfehr6 73 16 genome genome NN cord-316525-uadfehr6 73 17 based base VBN cord-316525-uadfehr6 73 18 on on IN cord-316525-uadfehr6 73 19 the the DT cord-316525-uadfehr6 73 20 segments segment NNS cord-316525-uadfehr6 73 21 with with IN cord-316525-uadfehr6 73 22 length length NN cord-316525-uadfehr6 74 1 > > XX cord-316525-uadfehr6 75 1 50 50 CD cord-316525-uadfehr6 75 2 and and CC cord-316525-uadfehr6 75 3 identity identity NN cord-316525-uadfehr6 75 4 > > XX cord-316525-uadfehr6 75 5 80 80 CD cord-316525-uadfehr6 75 6 % % NN cord-316525-uadfehr6 75 7 . . . cord-316525-uadfehr6 76 1 Of of RB cord-316525-uadfehr6 76 2 course course RB cord-316525-uadfehr6 76 3 , , , cord-316525-uadfehr6 76 4 the the DT cord-316525-uadfehr6 76 5 other other JJ cord-316525-uadfehr6 76 6 coronaviruses coronaviruse NNS cord-316525-uadfehr6 76 7 used use VBN cord-316525-uadfehr6 76 8 in in IN cord-316525-uadfehr6 76 9 the the DT cord-316525-uadfehr6 76 10 analysis analysis NN cord-316525-uadfehr6 76 11 are be VBP cord-316525-uadfehr6 76 12 also also RB cord-316525-uadfehr6 76 13 mosaic mosaic JJ cord-316525-uadfehr6 76 14 structures structure NNS cord-316525-uadfehr6 76 15 , , , cord-316525-uadfehr6 76 16 for for IN cord-316525-uadfehr6 76 17 more more JJR cord-316525-uadfehr6 76 18 sequence sequence NN cord-316525-uadfehr6 76 19 similarities similarity NNS cord-316525-uadfehr6 76 20 exist exist VBP cord-316525-uadfehr6 76 21 among among IN cord-316525-uadfehr6 76 22 them -PRON- PRP cord-316525-uadfehr6 76 23 than than IN cord-316525-uadfehr6 76 24 with with IN cord-316525-uadfehr6 76 25 SARS SARS NNP cord-316525-uadfehr6 76 26 - - HYPH cord-316525-uadfehr6 76 27 CoV. CoV. NNP cord-316525-uadfehr6 77 1 It -PRON- PRP cord-316525-uadfehr6 77 2 is be VBZ cord-316525-uadfehr6 77 3 noted note VBN cord-316525-uadfehr6 77 4 that that IN cord-316525-uadfehr6 77 5 all all PDT cord-316525-uadfehr6 77 6 the the DT cord-316525-uadfehr6 77 7 sequence sequence NN cord-316525-uadfehr6 77 8 comparisons comparison NNS cord-316525-uadfehr6 77 9 in in IN cord-316525-uadfehr6 77 10 this this DT cord-316525-uadfehr6 77 11 study study NN cord-316525-uadfehr6 77 12 are be VBP cord-316525-uadfehr6 77 13 based base VBN cord-316525-uadfehr6 77 14 on on IN cord-316525-uadfehr6 77 15 nucleotide nucleotide JJ cord-316525-uadfehr6 77 16 sequences sequence NNS cord-316525-uadfehr6 77 17 . . . cord-316525-uadfehr6 78 1 While while IN cord-316525-uadfehr6 78 2 the the DT cord-316525-uadfehr6 78 3 protein protein NN cord-316525-uadfehr6 78 4 sequences sequence NNS cord-316525-uadfehr6 78 5 in in IN cord-316525-uadfehr6 78 6 SARS SARS NNP cord-316525-uadfehr6 78 7 - - HYPH cord-316525-uadfehr6 78 8 CoV CoV NNP cord-316525-uadfehr6 78 9 are be VBP cord-316525-uadfehr6 78 10 largely largely RB cord-316525-uadfehr6 78 11 different different JJ cord-316525-uadfehr6 78 12 from from IN cord-316525-uadfehr6 78 13 those those DT cord-316525-uadfehr6 78 14 in in IN cord-316525-uadfehr6 78 15 the the DT cord-316525-uadfehr6 78 16 known know VBN cord-316525-uadfehr6 78 17 three three CD cord-316525-uadfehr6 78 18 groups group NNS cord-316525-uadfehr6 78 19 of of IN cord-316525-uadfehr6 78 20 coronavirus coronavirus NN cord-316525-uadfehr6 78 21 [ [ -LRB- cord-316525-uadfehr6 78 22 17 17 CD cord-316525-uadfehr6 78 23 ] ] -RRB- cord-316525-uadfehr6 78 24 , , , cord-316525-uadfehr6 78 25 such such JJ cord-316525-uadfehr6 78 26 as as IN cord-316525-uadfehr6 78 27 , , , cord-316525-uadfehr6 78 28 for for IN cord-316525-uadfehr6 78 29 S s NN cord-316525-uadfehr6 78 30 protein protein NN cord-316525-uadfehr6 78 31 , , , cord-316525-uadfehr6 78 32 the the DT cord-316525-uadfehr6 78 33 identity identity NN cord-316525-uadfehr6 78 34 is be VBZ cord-316525-uadfehr6 78 35 : : : cord-316525-uadfehr6 78 36 25.9 25.9 CD cord-316525-uadfehr6 78 37 % % NN cord-316525-uadfehr6 78 38 for for IN cord-316525-uadfehr6 78 39 SARS SARS NNP cord-316525-uadfehr6 78 40 - - HYPH cord-316525-uadfehr6 78 41 CoV CoV NNP cord-316525-uadfehr6 78 42 and and CC cord-316525-uadfehr6 78 43 BCoV BCoV NNP cord-316525-uadfehr6 78 44 , , , cord-316525-uadfehr6 78 45 21.7 21.7 CD cord-316525-uadfehr6 78 46 % % NN cord-316525-uadfehr6 78 47 for for IN cord-316525-uadfehr6 78 48 SARS SARS NNP cord-316525-uadfehr6 78 49 - - HYPH cord-316525-uadfehr6 78 50 CoV CoV NNP cord-316525-uadfehr6 78 51 and and CC cord-316525-uadfehr6 78 52 HCoV HCoV NNP cord-316525-uadfehr6 78 53 , , , cord-316525-uadfehr6 78 54 21.5 21.5 CD cord-316525-uadfehr6 78 55 % % NN cord-316525-uadfehr6 78 56 for for IN cord-316525-uadfehr6 78 57 SARS SARS NNP cord-316525-uadfehr6 78 58 - - HYPH cord-316525-uadfehr6 78 59 CoV CoV NNP cord-316525-uadfehr6 78 60 and and CC cord-316525-uadfehr6 78 61 IBV IBV NNP cord-316525-uadfehr6 78 62 , , , cord-316525-uadfehr6 78 63 25.6 25.6 CD cord-316525-uadfehr6 78 64 % % NN cord-316525-uadfehr6 78 65 for for IN cord-316525-uadfehr6 78 66 SARS SARS NNP cord-316525-uadfehr6 78 67 - - HYPH cord-316525-uadfehr6 78 68 CoV CoV NNP cord-316525-uadfehr6 78 69 and and CC cord-316525-uadfehr6 78 70 MHV MHV NNP cord-316525-uadfehr6 78 71 , , , cord-316525-uadfehr6 78 72 20.6 20.6 CD cord-316525-uadfehr6 78 73 % % NN cord-316525-uadfehr6 78 74 for for IN cord-316525-uadfehr6 78 75 SARS SARS NNP cord-316525-uadfehr6 78 76 - - HYPH cord-316525-uadfehr6 78 77 CoV CoV NNP cord-316525-uadfehr6 78 78 and and CC cord-316525-uadfehr6 78 79 PEDV PEDV NNP cord-316525-uadfehr6 78 80 , , , cord-316525-uadfehr6 78 81 19.4 19.4 CD cord-316525-uadfehr6 78 82 % % NN cord-316525-uadfehr6 78 83 for for IN cord-316525-uadfehr6 78 84 SARS SARS NNP cord-316525-uadfehr6 78 85 - - HYPH cord-316525-uadfehr6 78 86 CoV CoV NNP cord-316525-uadfehr6 78 87 and and CC cord-316525-uadfehr6 78 88 TGEV TGEV NNP cord-316525-uadfehr6 78 89 . . . cord-316525-uadfehr6 79 1 Although although IN cord-316525-uadfehr6 79 2 SARS SARS NNP cord-316525-uadfehr6 79 3 - - HYPH cord-316525-uadfehr6 79 4 CoV CoV NNP cord-316525-uadfehr6 79 5 is be VBZ cord-316525-uadfehr6 79 6 close close JJ cord-316525-uadfehr6 79 7 to to IN cord-316525-uadfehr6 79 8 BCoV BCoV NNP cord-316525-uadfehr6 79 9 , , , cord-316525-uadfehr6 79 10 MHV MHV NNP cord-316525-uadfehr6 79 11 , , , cord-316525-uadfehr6 79 12 TGEV TGEV NNP cord-316525-uadfehr6 79 13 and and CC cord-316525-uadfehr6 79 14 IBV IBV NNP cord-316525-uadfehr6 79 15 , , , cord-316525-uadfehr6 79 16 the the DT cord-316525-uadfehr6 79 17 corresponding correspond VBG cord-316525-uadfehr6 79 18 protein protein NN cord-316525-uadfehr6 79 19 , , , cord-316525-uadfehr6 79 20 replicase replicase NNP cord-316525-uadfehr6 79 21 1a 1a NNP cord-316525-uadfehr6 79 22 , , , cord-316525-uadfehr6 79 23 is be VBZ cord-316525-uadfehr6 79 24 still still RB cord-316525-uadfehr6 79 25 different different JJ cord-316525-uadfehr6 79 26 : : : cord-316525-uadfehr6 79 27 with with IN cord-316525-uadfehr6 79 28 identity identity NN cord-316525-uadfehr6 79 29 27.4 27.4 CD cord-316525-uadfehr6 79 30 % % NN cord-316525-uadfehr6 79 31 for for IN cord-316525-uadfehr6 79 32 SARS SARS NNP cord-316525-uadfehr6 79 33 - - HYPH cord-316525-uadfehr6 79 34 CoV CoV NNP cord-316525-uadfehr6 79 35 and and CC cord-316525-uadfehr6 79 36 BCoV BCoV NNP cord-316525-uadfehr6 79 37 , , , cord-316525-uadfehr6 79 38 24.8 24.8 CD cord-316525-uadfehr6 79 39 % % NN cord-316525-uadfehr6 79 40 for for IN cord-316525-uadfehr6 79 41 SARS SARS NNP cord-316525-uadfehr6 79 42 - - HYPH cord-316525-uadfehr6 79 43 CoV CoV NNP cord-316525-uadfehr6 79 44 and and CC cord-316525-uadfehr6 79 45 IBV IBV NNP cord-316525-uadfehr6 79 46 , , , cord-316525-uadfehr6 79 47 32.2 32.2 CD cord-316525-uadfehr6 79 48 % % NN cord-316525-uadfehr6 79 49 for for IN cord-316525-uadfehr6 79 50 SARS SARS NNP cord-316525-uadfehr6 79 51 - - HYPH cord-316525-uadfehr6 79 52 CoV CoV NNP cord-316525-uadfehr6 79 53 and and CC cord-316525-uadfehr6 79 54 MHV MHV NNP cord-316525-uadfehr6 79 55 , , , cord-316525-uadfehr6 79 56 25.0 25.0 CD cord-316525-uadfehr6 79 57 % % NN cord-316525-uadfehr6 79 58 for for IN cord-316525-uadfehr6 79 59 SARS SARS NNP cord-316525-uadfehr6 79 60 - - HYPH cord-316525-uadfehr6 79 61 CoV CoV NNP cord-316525-uadfehr6 79 62 and and CC cord-316525-uadfehr6 79 63 TGEV TGEV NNP cord-316525-uadfehr6 79 64 . . . cord-316525-uadfehr6 80 1 Naturally naturally RB cord-316525-uadfehr6 80 2 , , , cord-316525-uadfehr6 80 3 we -PRON- PRP cord-316525-uadfehr6 80 4 should should MD cord-316525-uadfehr6 80 5 take take VB cord-316525-uadfehr6 80 6 into into IN cord-316525-uadfehr6 80 7 account account NN cord-316525-uadfehr6 80 8 the the DT cord-316525-uadfehr6 80 9 role role NN cord-316525-uadfehr6 80 10 of of IN cord-316525-uadfehr6 80 11 convergent convergent JJ cord-316525-uadfehr6 80 12 evolution evolution NN cord-316525-uadfehr6 80 13 , , , cord-316525-uadfehr6 80 14 which which WDT cord-316525-uadfehr6 80 15 would would MD cord-316525-uadfehr6 80 16 bear bear VB cord-316525-uadfehr6 80 17 its -PRON- PRP$ cord-316525-uadfehr6 80 18 mark mark NN cord-316525-uadfehr6 80 19 on on IN cord-316525-uadfehr6 80 20 the the DT cord-316525-uadfehr6 80 21 viral viral JJ cord-316525-uadfehr6 80 22 genome genome NN cord-316525-uadfehr6 80 23 . . . cord-316525-uadfehr6 81 1 The the DT cord-316525-uadfehr6 81 2 recombination recombination NN cord-316525-uadfehr6 81 3 events event NNS cord-316525-uadfehr6 81 4 that that WDT cord-316525-uadfehr6 81 5 we -PRON- PRP cord-316525-uadfehr6 81 6 witnessed witness VBD cord-316525-uadfehr6 81 7 in in IN cord-316525-uadfehr6 81 8 SARS SARS NNP cord-316525-uadfehr6 81 9 - - HYPH cord-316525-uadfehr6 81 10 CoV CoV NNP cord-316525-uadfehr6 81 11 are be VBP cord-316525-uadfehr6 81 12 present present JJ cord-316525-uadfehr6 81 13 in in IN cord-316525-uadfehr6 81 14 six six CD cord-316525-uadfehr6 81 15 different different JJ cord-316525-uadfehr6 81 16 viruses virus NNS cord-316525-uadfehr6 81 17 , , , cord-316525-uadfehr6 81 18 suggesting suggest VBG cord-316525-uadfehr6 81 19 sequential sequential JJ cord-316525-uadfehr6 81 20 horizontal horizontal JJ cord-316525-uadfehr6 81 21 transfers transfer NNS cord-316525-uadfehr6 81 22 and and CC cord-316525-uadfehr6 81 23 progressive progressive JJ cord-316525-uadfehr6 81 24 adaptation adaptation NN cord-316525-uadfehr6 81 25 to to IN cord-316525-uadfehr6 81 26 new new JJ cord-316525-uadfehr6 81 27 hosts host NNS cord-316525-uadfehr6 81 28 cells cell NNS cord-316525-uadfehr6 81 29 or or CC cord-316525-uadfehr6 81 30 animals animal NNS cord-316525-uadfehr6 81 31 . . . cord-316525-uadfehr6 82 1 Indeed indeed RB cord-316525-uadfehr6 82 2 because because IN cord-316525-uadfehr6 82 3 viruses virus NNS cord-316525-uadfehr6 82 4 need need VBP cord-316525-uadfehr6 82 5 both both DT cord-316525-uadfehr6 82 6 receptors receptor NNS cord-316525-uadfehr6 82 7 to to TO cord-316525-uadfehr6 82 8 permeate permeate VB cord-316525-uadfehr6 82 9 host host NN cord-316525-uadfehr6 82 10 cells cell NNS cord-316525-uadfehr6 82 11 and and CC cord-316525-uadfehr6 82 12 resist resist VB cord-316525-uadfehr6 82 13 the the DT cord-316525-uadfehr6 82 14 immune immune JJ cord-316525-uadfehr6 82 15 response response NN cord-316525-uadfehr6 82 16 of of IN cord-316525-uadfehr6 82 17 the the DT cord-316525-uadfehr6 82 18 host host NN cord-316525-uadfehr6 82 19 , , , cord-316525-uadfehr6 82 20 their -PRON- PRP$ cord-316525-uadfehr6 82 21 outer outer JJ cord-316525-uadfehr6 82 22 layer layer NN cord-316525-uadfehr6 82 23 proteins protein NNS cord-316525-uadfehr6 82 24 are be VBP cord-316525-uadfehr6 82 25 submitted submit VBN cord-316525-uadfehr6 82 26 to to IN cord-316525-uadfehr6 82 27 an an DT cord-316525-uadfehr6 82 28 extremely extremely RB cord-316525-uadfehr6 82 29 strong strong JJ cord-316525-uadfehr6 82 30 selection selection NN cord-316525-uadfehr6 82 31 pressure pressure NN cord-316525-uadfehr6 82 32 that that WDT cord-316525-uadfehr6 82 33 may may MD cord-316525-uadfehr6 82 34 restrict restrict VB cord-316525-uadfehr6 82 35 considerably considerably RB cord-316525-uadfehr6 82 36 the the DT cord-316525-uadfehr6 82 37 possible possible JJ cord-316525-uadfehr6 82 38 variations variation NNS cord-316525-uadfehr6 82 39 of of IN cord-316525-uadfehr6 82 40 the the DT cord-316525-uadfehr6 82 41 corresponding correspond VBG cord-316525-uadfehr6 82 42 proteins protein NNS cord-316525-uadfehr6 82 43 ( ( -LRB- cord-316525-uadfehr6 82 44 and and CC cord-316525-uadfehr6 82 45 accordingly accordingly RB cord-316525-uadfehr6 82 46 of of IN cord-316525-uadfehr6 82 47 the the DT cord-316525-uadfehr6 82 48 corresponding correspond VBG cord-316525-uadfehr6 82 49 genome genome NN cord-316525-uadfehr6 82 50 pieces piece NNS cord-316525-uadfehr6 82 51 of of IN cord-316525-uadfehr6 82 52 sequences sequence NNS cord-316525-uadfehr6 82 53 ) ) -RRB- cord-316525-uadfehr6 82 54 . . . cord-316525-uadfehr6 83 1 It -PRON- PRP cord-316525-uadfehr6 83 2 is be VBZ cord-316525-uadfehr6 83 3 nevertheless nevertheless RB cord-316525-uadfehr6 83 4 remarkable remarkable JJ cord-316525-uadfehr6 83 5 that that IN cord-316525-uadfehr6 83 6 , , , cord-316525-uadfehr6 83 7 despite despite IN cord-316525-uadfehr6 83 8 the the DT cord-316525-uadfehr6 83 9 inclusion inclusion NN cord-316525-uadfehr6 83 10 of of IN cord-316525-uadfehr6 83 11 all all DT cord-316525-uadfehr6 83 12 possible possible JJ cord-316525-uadfehr6 83 13 types type NNS cord-316525-uadfehr6 83 14 of of IN cord-316525-uadfehr6 83 15 viruses virus NNS cord-316525-uadfehr6 83 16 in in IN cord-316525-uadfehr6 83 17 our -PRON- PRP$ cord-316525-uadfehr6 83 18 sample sample NN cord-316525-uadfehr6 83 19 set set NN cord-316525-uadfehr6 83 20 ( ( -LRB- cord-316525-uadfehr6 83 21 as as RB cord-316525-uadfehr6 83 22 well well RB cord-316525-uadfehr6 83 23 as as IN cord-316525-uadfehr6 83 24 shuffled shuffle VBN cord-316525-uadfehr6 83 25 genomes genome NNS cord-316525-uadfehr6 83 26 from from IN cord-316525-uadfehr6 83 27 the the DT cord-316525-uadfehr6 83 28 viruses virus NNS cord-316525-uadfehr6 83 29 we -PRON- PRP cord-316525-uadfehr6 83 30 have have VBP cord-316525-uadfehr6 83 31 identified identify VBN cord-316525-uadfehr6 83 32 as as IN cord-316525-uadfehr6 83 33 relevant relevant JJ cord-316525-uadfehr6 83 34 ) ) -RRB- cord-316525-uadfehr6 83 35 we -PRON- PRP cord-316525-uadfehr6 83 36 find find VBP cord-316525-uadfehr6 83 37 a a DT cord-316525-uadfehr6 83 38 more more RBR cord-316525-uadfehr6 83 39 or or CC cord-316525-uadfehr6 83 40 less less RBR cord-316525-uadfehr6 83 41 single single JJ cord-316525-uadfehr6 83 42 category category NN cord-316525-uadfehr6 83 43 of of IN cord-316525-uadfehr6 83 44 viruses virus NNS cord-316525-uadfehr6 83 45 as as IN cord-316525-uadfehr6 83 46 similar similar JJ cord-316525-uadfehr6 83 47 to to TO cord-316525-uadfehr6 83 48 SARS- sars- VB cord-316525-uadfehr6 84 1 CoV. CoV. NNP cord-316525-uadfehr6 85 1 This this DT cord-316525-uadfehr6 85 2 suggests suggest VBZ cord-316525-uadfehr6 85 3 that that IN cord-316525-uadfehr6 85 4 even even RB cord-316525-uadfehr6 85 5 if if IN cord-316525-uadfehr6 85 6 the the DT cord-316525-uadfehr6 85 7 contribution contribution NN cord-316525-uadfehr6 85 8 of of IN cord-316525-uadfehr6 85 9 convergent convergent JJ cord-316525-uadfehr6 85 10 evolution evolution NN cord-316525-uadfehr6 85 11 is be VBZ cord-316525-uadfehr6 85 12 important important JJ cord-316525-uadfehr6 85 13 , , , cord-316525-uadfehr6 85 14 this this DT cord-316525-uadfehr6 85 15 happened happen VBD cord-316525-uadfehr6 85 16 on on IN cord-316525-uadfehr6 85 17 a a DT cord-316525-uadfehr6 85 18 more more RBR cord-316525-uadfehr6 85 19 or or CC cord-316525-uadfehr6 85 20 less less RBR cord-316525-uadfehr6 85 21 common common JJ cord-316525-uadfehr6 85 22 phylogenetic phylogenetic JJ cord-316525-uadfehr6 85 23 background background NN cord-316525-uadfehr6 85 24 , , , cord-316525-uadfehr6 85 25 suggesting suggest VBG cord-316525-uadfehr6 85 26 several several JJ cord-316525-uadfehr6 85 27 steps step NNS cord-316525-uadfehr6 85 28 of of IN cord-316525-uadfehr6 85 29 recombination recombination NN cord-316525-uadfehr6 85 30 followed follow VBN cord-316525-uadfehr6 85 31 by by IN cord-316525-uadfehr6 85 32 fine fine JJ cord-316525-uadfehr6 85 33 adaptation adaptation NN cord-316525-uadfehr6 85 34 . . . cord-316525-uadfehr6 86 1 In in IN cord-316525-uadfehr6 86 2 this this DT cord-316525-uadfehr6 86 3 context context NN cord-316525-uadfehr6 86 4 , , , cord-316525-uadfehr6 86 5 we -PRON- PRP cord-316525-uadfehr6 86 6 would would MD cord-316525-uadfehr6 86 7 like like VB cord-316525-uadfehr6 86 8 to to TO cord-316525-uadfehr6 86 9 suggest suggest VB cord-316525-uadfehr6 86 10 that that IN cord-316525-uadfehr6 86 11 ancestors ancestor NNS cord-316525-uadfehr6 86 12 of of IN cord-316525-uadfehr6 86 13 PEDV PEDV NNP cord-316525-uadfehr6 86 14 , , , cord-316525-uadfehr6 86 15 MHV MHV NNP cord-316525-uadfehr6 86 16 or or CC cord-316525-uadfehr6 86 17 both both DT cord-316525-uadfehr6 86 18 are be VBP cord-316525-uadfehr6 86 19 the the DT cord-316525-uadfehr6 86 20 most most RBS cord-316525-uadfehr6 86 21 plausible plausible JJ cord-316525-uadfehr6 86 22 origin origin NN cord-316525-uadfehr6 86 23 of of IN cord-316525-uadfehr6 86 24 SARS SARS NNP cord-316525-uadfehr6 86 25 - - HYPH cord-316525-uadfehr6 86 26 CoV. CoV. NNP cord-316525-uadfehr6 86 27 Guan Guan NNP cord-316525-uadfehr6 86 28 et et FW cord-316525-uadfehr6 86 29 al al NNP cord-316525-uadfehr6 86 30 . . . cord-316525-uadfehr6 87 1 [ [ -LRB- cord-316525-uadfehr6 87 2 7 7 CD cord-316525-uadfehr6 87 3 ] ] -RRB- cord-316525-uadfehr6 87 4 Based base VBN cord-316525-uadfehr6 87 5 on on IN cord-316525-uadfehr6 87 6 phylogenetic phylogenetic JJ cord-316525-uadfehr6 87 7 techniques technique NNS cord-316525-uadfehr6 87 8 and and CC cord-316525-uadfehr6 87 9 BOOTSCAN BOOTSCAN NNP cord-316525-uadfehr6 87 10 recombination recombination NN cord-316525-uadfehr6 87 11 analysis analysis NN cord-316525-uadfehr6 87 12 Stavrinides stavrinide NNS cord-316525-uadfehr6 87 13 and and CC cord-316525-uadfehr6 87 14 Guttman Guttman NNP cord-316525-uadfehr6 88 1 [ [ -LRB- cord-316525-uadfehr6 88 2 32 32 CD cord-316525-uadfehr6 88 3 ] ] -RRB- cord-316525-uadfehr6 88 4 indicated indicate VBD cord-316525-uadfehr6 88 5 that that IN cord-316525-uadfehr6 88 6 the the DT cord-316525-uadfehr6 88 7 replicase replicase NN cord-316525-uadfehr6 88 8 of of IN cord-316525-uadfehr6 88 9 SARS SARS NNP cord-316525-uadfehr6 88 10 - - HYPH cord-316525-uadfehr6 88 11 CoV CoV NNP cord-316525-uadfehr6 88 12 was be VBD cord-316525-uadfehr6 88 13 a a DT cord-316525-uadfehr6 88 14 mammalian mammalian JJ cord-316525-uadfehr6 88 15 - - HYPH cord-316525-uadfehr6 88 16 like like JJ cord-316525-uadfehr6 88 17 origin origin NN cord-316525-uadfehr6 88 18 , , , cord-316525-uadfehr6 88 19 the the DT cord-316525-uadfehr6 88 20 M M NNP cord-316525-uadfehr6 88 21 and and CC cord-316525-uadfehr6 88 22 N n CD cord-316525-uadfehr6 88 23 proteins protein NNS cord-316525-uadfehr6 88 24 have have VBP cord-316525-uadfehr6 88 25 an an DT cord-316525-uadfehr6 88 26 avian avian JJ cord-316525-uadfehr6 88 27 - - HYPH cord-316525-uadfehr6 88 28 like like JJ cord-316525-uadfehr6 88 29 origin origin NN cord-316525-uadfehr6 88 30 , , , cord-316525-uadfehr6 88 31 and and CC cord-316525-uadfehr6 88 32 the the DT cord-316525-uadfehr6 88 33 S S NNP cord-316525-uadfehr6 88 34 protein protein NN cord-316525-uadfehr6 88 35 has have VBZ cord-316525-uadfehr6 88 36 a a DT cord-316525-uadfehr6 88 37 mammalian mammalian JJ cord-316525-uadfehr6 88 38 - - HYPH cord-316525-uadfehr6 88 39 avian avian JJ cord-316525-uadfehr6 88 40 mosaic mosaic JJ cord-316525-uadfehr6 88 41 origin origin NN cord-316525-uadfehr6 88 42 . . . cord-316525-uadfehr6 89 1 While while IN cord-316525-uadfehr6 89 2 in in IN cord-316525-uadfehr6 89 3 the the DT cord-316525-uadfehr6 89 4 present present JJ cord-316525-uadfehr6 89 5 study study NN cord-316525-uadfehr6 89 6 we -PRON- PRP cord-316525-uadfehr6 89 7 used use VBD cord-316525-uadfehr6 89 8 phylogenetic phylogenetic JJ cord-316525-uadfehr6 89 9 analysis analysis NN cord-316525-uadfehr6 89 10 and and CC cord-316525-uadfehr6 89 11 7 7 CD cord-316525-uadfehr6 89 12 recombination recombination NN cord-316525-uadfehr6 89 13 detection detection NN cord-316525-uadfehr6 89 14 methods method NNS cord-316525-uadfehr6 89 15 , , , cord-316525-uadfehr6 89 16 including include VBG cord-316525-uadfehr6 89 17 the the DT cord-316525-uadfehr6 89 18 powerful powerful JJ cord-316525-uadfehr6 89 19 methods method NNS cord-316525-uadfehr6 89 20 of of IN cord-316525-uadfehr6 89 21 MAXCHI MAXCHI NNP cord-316525-uadfehr6 89 22 and and CC cord-316525-uadfehr6 89 23 GENECONV GENECONV NNP cord-316525-uadfehr6 89 24 among among IN cord-316525-uadfehr6 89 25 14 14 CD cord-316525-uadfehr6 89 26 methods method NNS cord-316525-uadfehr6 89 27 studied study VBN cord-316525-uadfehr6 89 28 ( ( -LRB- cord-316525-uadfehr6 89 29 SIMPLOT SIMPLOT NNP cord-316525-uadfehr6 89 30 ( ( -LRB- cord-316525-uadfehr6 89 31 BOOTSCAN BOOTSCAN NNP cord-316525-uadfehr6 89 32 ) ) -RRB- cord-316525-uadfehr6 89 33 , , , cord-316525-uadfehr6 89 34 GENECONV GENECONV NNP cord-316525-uadfehr6 89 35 , , , cord-316525-uadfehr6 89 36 HOMOPLASY HOMOPLASY NNP cord-316525-uadfehr6 89 37 TEST test NN cord-316525-uadfehr6 89 38 , , , cord-316525-uadfehr6 89 39 PIST PIST NNP cord-316525-uadfehr6 89 40 , , , cord-316525-uadfehr6 89 41 _SP cord-316525-uadfehr6 89 42 MAXCHI MAXCHI NNP cord-316525-uadfehr6 89 43 , , , cord-316525-uadfehr6 89 44 CHIMAERA CHIMAERA NNP cord-316525-uadfehr6 89 45 , , , cord-316525-uadfehr6 89 46 PHYPRO PHYPRO NNP cord-316525-uadfehr6 89 47 , , , cord-316525-uadfehr6 89 48 PLATO PLATO NNP cord-316525-uadfehr6 89 49 , , , cord-316525-uadfehr6 89 50 RDP RDP NNP cord-316525-uadfehr6 89 51 , , , cord-316525-uadfehr6 89 52 RECPARS recpar NNS cord-316525-uadfehr6 89 53 , , , cord-316525-uadfehr6 89 54 RETICULATE RETICULATE NNP cord-316525-uadfehr6 89 55 , , , cord-316525-uadfehr6 89 56 _SP cord-316525-uadfehr6 89 57 RUNS RUNS NNP cord-316525-uadfehr6 89 58 TEST test NN cord-316525-uadfehr6 89 59 , , , cord-316525-uadfehr6 89 60 SNEATH SNEATH NNP cord-316525-uadfehr6 89 61 TEST test NN cord-316525-uadfehr6 89 62 , , , cord-316525-uadfehr6 89 63 TRIPLE TRIPLE NNP cord-316525-uadfehr6 89 64 ) ) -RRB- cord-316525-uadfehr6 89 65 [ [ -LRB- cord-316525-uadfehr6 89 66 23 23 CD cord-316525-uadfehr6 89 67 , , , cord-316525-uadfehr6 89 68 24 24 CD cord-316525-uadfehr6 89 69 ] ] -RRB- cord-316525-uadfehr6 89 70 , , , cord-316525-uadfehr6 89 71 to to TO cord-316525-uadfehr6 89 72 conduct conduct VB cord-316525-uadfehr6 89 73 whole whole JJ cord-316525-uadfehr6 89 74 genomewide genomewide NNP cord-316525-uadfehr6 89 75 recombination recombination NN cord-316525-uadfehr6 89 76 analysis analysis NN cord-316525-uadfehr6 89 77 . . . cord-316525-uadfehr6 90 1 We -PRON- PRP cord-316525-uadfehr6 90 2 identified identify VBD cord-316525-uadfehr6 90 3 seven seven CD cord-316525-uadfehr6 90 4 putative putative JJ cord-316525-uadfehr6 90 5 recombination recombination NN cord-316525-uadfehr6 90 6 regions region NNS cord-316525-uadfehr6 90 7 , , , cord-316525-uadfehr6 90 8 which which WDT cord-316525-uadfehr6 90 9 encompass encompass VBP cord-316525-uadfehr6 90 10 , , , cord-316525-uadfehr6 90 11 in in IN cord-316525-uadfehr6 90 12 terms term NNS cord-316525-uadfehr6 90 13 of of IN cord-316525-uadfehr6 90 14 proteins protein NNS cord-316525-uadfehr6 90 15 involved involve VBN cord-316525-uadfehr6 90 16 , , , cord-316525-uadfehr6 90 17 replicase replicase NNP cord-316525-uadfehr6 90 18 1A 1A NNP cord-316525-uadfehr6 90 19 , , , cord-316525-uadfehr6 90 20 replicase replicase NNP cord-316525-uadfehr6 90 21 1B 1B NNP cord-316525-uadfehr6 90 22 and and CC cord-316525-uadfehr6 90 23 the the DT cord-316525-uadfehr6 90 24 spike spike NN cord-316525-uadfehr6 90 25 glycoprotein glycoprotein NN cord-316525-uadfehr6 90 26 . . . cord-316525-uadfehr6 91 1 Stavrinides Stavrinides NNP cord-316525-uadfehr6 91 2 and and CC cord-316525-uadfehr6 91 3 Guttman Guttman NNP cord-316525-uadfehr6 91 4 [ [ -LRB- cord-316525-uadfehr6 91 5 32 32 CD cord-316525-uadfehr6 91 6 ] ] -RRB- cord-316525-uadfehr6 91 7 primarily primarily RB cord-316525-uadfehr6 91 8 inferred infer VBD cord-316525-uadfehr6 91 9 the the DT cord-316525-uadfehr6 91 10 occurrence occurrence NN cord-316525-uadfehr6 91 11 of of IN cord-316525-uadfehr6 91 12 recombination recombination NN cord-316525-uadfehr6 91 13 qualitatively qualitatively RB cord-316525-uadfehr6 91 14 , , , cord-316525-uadfehr6 91 15 but but CC cord-316525-uadfehr6 91 16 did do VBD cord-316525-uadfehr6 91 17 not not RB cord-316525-uadfehr6 91 18 identify identify VB cord-316525-uadfehr6 91 19 the the DT cord-316525-uadfehr6 91 20 precise precise JJ cord-316525-uadfehr6 91 21 recombination recombination NN cord-316525-uadfehr6 91 22 region region NN cord-316525-uadfehr6 91 23 in in IN cord-316525-uadfehr6 91 24 the the DT cord-316525-uadfehr6 91 25 protein protein NN cord-316525-uadfehr6 91 26 involved involve VBN cord-316525-uadfehr6 91 27 ( ( -LRB- cord-316525-uadfehr6 91 28 the the DT cord-316525-uadfehr6 91 29 S S NNP cord-316525-uadfehr6 91 30 protein protein NN cord-316525-uadfehr6 91 31 is be VBZ cord-316525-uadfehr6 91 32 an an DT cord-316525-uadfehr6 91 33 exception exception NN cord-316525-uadfehr6 91 34 , , , cord-316525-uadfehr6 91 35 they -PRON- PRP cord-316525-uadfehr6 91 36 identified identify VBD cord-316525-uadfehr6 91 37 a a DT cord-316525-uadfehr6 91 38 recombination recombination NN cord-316525-uadfehr6 91 39 region region NN cord-316525-uadfehr6 91 40 in in IN cord-316525-uadfehr6 91 41 S S NNP cord-316525-uadfehr6 91 42 protein protein NN cord-316525-uadfehr6 91 43 , , , cord-316525-uadfehr6 91 44 located locate VBN cord-316525-uadfehr6 91 45 between between IN cord-316525-uadfehr6 91 46 nucleotides nucleotide NNS cord-316525-uadfehr6 91 47 2472 2472 CD cord-316525-uadfehr6 91 48 and and CC cord-316525-uadfehr6 91 49 2694 2694 CD cord-316525-uadfehr6 91 50 of of IN cord-316525-uadfehr6 91 51 the the DT cord-316525-uadfehr6 91 52 S S NNP cord-316525-uadfehr6 91 53 protein protein NN cord-316525-uadfehr6 91 54 , , , cord-316525-uadfehr6 91 55 i.e. i.e. FW cord-316525-uadfehr6 91 56 between between IN cord-316525-uadfehr6 91 57 nucleotides nucleotide NNS cord-316525-uadfehr6 91 58 23963 23963 CD cord-316525-uadfehr6 91 59 and and CC cord-316525-uadfehr6 91 60 24185 24185 CD cord-316525-uadfehr6 91 61 of of IN cord-316525-uadfehr6 91 62 the the DT cord-316525-uadfehr6 91 63 SARS SARS NNP cord-316525-uadfehr6 91 64 - - HYPH cord-316525-uadfehr6 91 65 CoV CoV NNP cord-316525-uadfehr6 91 66 genome genome NN cord-316525-uadfehr6 91 67 , , , cord-316525-uadfehr6 91 68 basically basically RB cord-316525-uadfehr6 91 69 covered cover VBN cord-316525-uadfehr6 91 70 by by IN cord-316525-uadfehr6 91 71 the the DT cord-316525-uadfehr6 91 72 last last JJ cord-316525-uadfehr6 91 73 recombination recombination NN cord-316525-uadfehr6 91 74 region region NN cord-316525-uadfehr6 91 75 for for IN cord-316525-uadfehr6 91 76 S s NN cord-316525-uadfehr6 91 77 protein protein NN cord-316525-uadfehr6 91 78 ( ( -LRB- cord-316525-uadfehr6 91 79 Table Table NNP cord-316525-uadfehr6 91 80 6 6 CD cord-316525-uadfehr6 91 81 ) ) -RRB- cord-316525-uadfehr6 91 82 ) ) -RRB- cord-316525-uadfehr6 91 83 . . . cord-316525-uadfehr6 92 1 Most most RBS cord-316525-uadfehr6 92 2 importantly importantly RB cord-316525-uadfehr6 92 3 , , , cord-316525-uadfehr6 92 4 each each DT cord-316525-uadfehr6 92 5 of of IN cord-316525-uadfehr6 92 6 our -PRON- PRP$ cord-316525-uadfehr6 92 7 recombination recombination NN cord-316525-uadfehr6 92 8 regions region NNS cord-316525-uadfehr6 92 9 is be VBZ cord-316525-uadfehr6 92 10 identified identify VBN cord-316525-uadfehr6 92 11 by by IN cord-316525-uadfehr6 92 12 at at RB cord-316525-uadfehr6 92 13 least least JJS cord-316525-uadfehr6 92 14 3 3 CD cord-316525-uadfehr6 92 15 methods method NNS cord-316525-uadfehr6 92 16 , , , cord-316525-uadfehr6 92 17 because because IN cord-316525-uadfehr6 92 18 one one PRP cord-316525-uadfehr6 92 19 should should MD cord-316525-uadfehr6 92 20 not not RB cord-316525-uadfehr6 92 21 rely rely VB cord-316525-uadfehr6 92 22 too too RB cord-316525-uadfehr6 92 23 much much RB cord-316525-uadfehr6 92 24 on on IN cord-316525-uadfehr6 92 25 a a DT cord-316525-uadfehr6 92 26 single single JJ cord-316525-uadfehr6 92 27 method method NN cord-316525-uadfehr6 92 28 , , , cord-316525-uadfehr6 92 29 as as IN cord-316525-uadfehr6 92 30 suggested suggest VBN cord-316525-uadfehr6 92 31 in in IN cord-316525-uadfehr6 92 32 [ [ -LRB- cord-316525-uadfehr6 92 33 23 23 CD cord-316525-uadfehr6 92 34 ] ] -RRB- cord-316525-uadfehr6 92 35 . . . cord-316525-uadfehr6 93 1 In in IN cord-316525-uadfehr6 93 2 general general JJ cord-316525-uadfehr6 93 3 , , , cord-316525-uadfehr6 93 4 we -PRON- PRP cord-316525-uadfehr6 93 5 believe believe VBP cord-316525-uadfehr6 93 6 two two CD cord-316525-uadfehr6 93 7 studies study NNS cord-316525-uadfehr6 93 8 lead lead VBP cord-316525-uadfehr6 93 9 to to IN cord-316525-uadfehr6 93 10 the the DT cord-316525-uadfehr6 93 11 overall overall JJ cord-316525-uadfehr6 93 12 conclusion conclusion NN cord-316525-uadfehr6 93 13 : : : cord-316525-uadfehr6 93 14 the the DT cord-316525-uadfehr6 93 15 evolution evolution NN cord-316525-uadfehr6 93 16 of of IN cord-316525-uadfehr6 93 17 SARS SARS NNP cord-316525-uadfehr6 93 18 - - HYPH cord-316525-uadfehr6 93 19 CoV CoV NNP cord-316525-uadfehr6 93 20 has have VBZ cord-316525-uadfehr6 93 21 involved involve VBN cord-316525-uadfehr6 93 22 recombination recombination NN cord-316525-uadfehr6 93 23 . . . cord-316525-uadfehr6 94 1 The the DT cord-316525-uadfehr6 94 2 recombination recombination NN cord-316525-uadfehr6 94 3 event event NN cord-316525-uadfehr6 94 4 in in IN cord-316525-uadfehr6 94 5 the the DT cord-316525-uadfehr6 94 6 replicase replicase NN cord-316525-uadfehr6 94 7 is be VBZ cord-316525-uadfehr6 94 8 related relate VBN cord-316525-uadfehr6 94 9 to to IN cord-316525-uadfehr6 94 10 the the DT cord-316525-uadfehr6 94 11 fact fact NN cord-316525-uadfehr6 94 12 that that IN cord-316525-uadfehr6 94 13 the the DT cord-316525-uadfehr6 94 14 RNA RNA NNP cord-316525-uadfehr6 94 15 polymerase polymerase NN cord-316525-uadfehr6 94 16 of of IN cord-316525-uadfehr6 94 17 coronaviruses coronaviruse NNS cord-316525-uadfehr6 94 18 utilize utilize VBP cord-316525-uadfehr6 94 19 a a DT cord-316525-uadfehr6 94 20 discontinuous discontinuous JJ cord-316525-uadfehr6 94 21 transcription transcription NN cord-316525-uadfehr6 94 22 mechanism mechanism NN cord-316525-uadfehr6 94 23 to to TO cord-316525-uadfehr6 94 24 synthesize synthesize VB cord-316525-uadfehr6 94 25 mRNAs mrnas CD cord-316525-uadfehr6 94 26 . . . cord-316525-uadfehr6 95 1 The the DT cord-316525-uadfehr6 95 2 viral viral JJ cord-316525-uadfehr6 95 3 polymerase polymerase NN cord-316525-uadfehr6 95 4 must must MD cord-316525-uadfehr6 95 5 jump jump VB cord-316525-uadfehr6 95 6 between between IN cord-316525-uadfehr6 95 7 different different JJ cord-316525-uadfehr6 95 8 RNA RNA NNP cord-316525-uadfehr6 95 9 templates template NNS cord-316525-uadfehr6 95 10 regularly regularly RB cord-316525-uadfehr6 95 11 during during IN cord-316525-uadfehr6 95 12 positive positive JJ cord-316525-uadfehr6 95 13 - - HYPH cord-316525-uadfehr6 95 14 or or CC cord-316525-uadfehr6 95 15 negative negative JJ cord-316525-uadfehr6 95 16 - - HYPH cord-316525-uadfehr6 95 17 strand strand NN cord-316525-uadfehr6 95 18 RNA RNA NNP cord-316525-uadfehr6 95 19 synthesis synthesis NN cord-316525-uadfehr6 95 20 and and CC cord-316525-uadfehr6 95 21 depending depend VBG cord-316525-uadfehr6 95 22 on on IN cord-316525-uadfehr6 95 23 the the DT cord-316525-uadfehr6 95 24 rejoining rejoin VBG cord-316525-uadfehr6 95 25 sites site NNS cord-316525-uadfehr6 95 26 , , , cord-316525-uadfehr6 95 27 the the DT cord-316525-uadfehr6 95 28 resultant resultant JJ cord-316525-uadfehr6 95 29 RNA RNA NNP cord-316525-uadfehr6 95 30 recombination recombination NN cord-316525-uadfehr6 95 31 will will MD cord-316525-uadfehr6 95 32 be be VB cord-316525-uadfehr6 95 33 either either CC cord-316525-uadfehr6 95 34 homologous homologous JJ cord-316525-uadfehr6 95 35 or or CC cord-316525-uadfehr6 95 36 nonhomologous nonhomologous JJ cord-316525-uadfehr6 95 37 . . . cord-316525-uadfehr6 96 1 This this DT cord-316525-uadfehr6 96 2 is be VBZ cord-316525-uadfehr6 96 3 the the DT cord-316525-uadfehr6 96 4 copy copy NN cord-316525-uadfehr6 96 5 - - HYPH cord-316525-uadfehr6 96 6 choice choice NN cord-316525-uadfehr6 96 7 model model NN cord-316525-uadfehr6 96 8 of of IN cord-316525-uadfehr6 96 9 recombination recombination NN cord-316525-uadfehr6 96 10 in in IN cord-316525-uadfehr6 96 11 RNA RNA NNP cord-316525-uadfehr6 96 12 viruses virus NNS cord-316525-uadfehr6 96 13 [ [ -LRB- cord-316525-uadfehr6 96 14 13 13 CD cord-316525-uadfehr6 96 15 , , , cord-316525-uadfehr6 96 16 27 27 CD cord-316525-uadfehr6 96 17 , , , cord-316525-uadfehr6 96 18 31 31 CD cord-316525-uadfehr6 96 19 , , , cord-316525-uadfehr6 96 20 34 34 CD cord-316525-uadfehr6 96 21 ] ] -RRB- cord-316525-uadfehr6 96 22 . . . cord-316525-uadfehr6 97 1 The the DT cord-316525-uadfehr6 97 2 recombination recombination NN cord-316525-uadfehr6 97 3 event event NN cord-316525-uadfehr6 97 4 in in IN cord-316525-uadfehr6 97 5 S S NNP cord-316525-uadfehr6 97 6 protein protein NN cord-316525-uadfehr6 97 7 is be VBZ cord-316525-uadfehr6 97 8 certainly certainly RB cord-316525-uadfehr6 97 9 important important JJ cord-316525-uadfehr6 97 10 since since IN cord-316525-uadfehr6 97 11 this this DT cord-316525-uadfehr6 97 12 allows allow VBZ cord-316525-uadfehr6 97 13 the the DT cord-316525-uadfehr6 97 14 virus virus NN cord-316525-uadfehr6 97 15 to to TO cord-316525-uadfehr6 97 16 alter alter VB cord-316525-uadfehr6 97 17 surface surface NN cord-316525-uadfehr6 97 18 antigenicity antigenicity NN cord-316525-uadfehr6 97 19 and and CC cord-316525-uadfehr6 97 20 escape escape VB cord-316525-uadfehr6 97 21 immunesurveillance immunesurveillance NN cord-316525-uadfehr6 97 22 in in IN cord-316525-uadfehr6 97 23 the the DT cord-316525-uadfehr6 97 24 animals animal NNS cord-316525-uadfehr6 97 25 , , , cord-316525-uadfehr6 97 26 thus thus RB cord-316525-uadfehr6 97 27 adapting adapt VBG cord-316525-uadfehr6 97 28 to to IN cord-316525-uadfehr6 97 29 a a DT cord-316525-uadfehr6 97 30 human human JJ cord-316525-uadfehr6 97 31 host host NN cord-316525-uadfehr6 97 32 . . . cord-316525-uadfehr6 98 1 The the DT cord-316525-uadfehr6 98 2 existence existence NN cord-316525-uadfehr6 98 3 of of IN cord-316525-uadfehr6 98 4 SARS SARS NNP cord-316525-uadfehr6 98 5 - - HYPH cord-316525-uadfehr6 98 6 CoV CoV NNP cord-316525-uadfehr6 98 7 - - HYPH cord-316525-uadfehr6 98 8 like like JJ cord-316525-uadfehr6 98 9 viruses virus NNS cord-316525-uadfehr6 98 10 ( ( -LRB- cord-316525-uadfehr6 98 11 99.8 99.8 CD cord-316525-uadfehr6 98 12 % % NN cord-316525-uadfehr6 98 13 homology homology NN cord-316525-uadfehr6 98 14 to to IN cord-316525-uadfehr6 98 15 human human JJ cord-316525-uadfehr6 98 16 SARS SARS NNP cord-316525-uadfehr6 98 17 - - HYPH cord-316525-uadfehr6 98 18 CoV CoV NNP cord-316525-uadfehr6 98 19 ) ) -RRB- cord-316525-uadfehr6 98 20 in in IN cord-316525-uadfehr6 98 21 several several JJ cord-316525-uadfehr6 98 22 wild wild JJ cord-316525-uadfehr6 98 23 animals animal NNS cord-316525-uadfehr6 98 24 in in IN cord-316525-uadfehr6 98 25 a a DT cord-316525-uadfehr6 98 26 live live JJ cord-316525-uadfehr6 98 27 animal animal NN cord-316525-uadfehr6 98 28 market market NN cord-316525-uadfehr6 98 29 in in IN cord-316525-uadfehr6 98 30 Guangdong Guangdong NNP cord-316525-uadfehr6 98 31 [ [ -LRB- cord-316525-uadfehr6 98 32 7 7 CD cord-316525-uadfehr6 98 33 ] ] -RRB- cord-316525-uadfehr6 98 34 indicated indicate VBD cord-316525-uadfehr6 98 35 that that IN cord-316525-uadfehr6 98 36 interspecies interspecie NNS cord-316525-uadfehr6 98 37 transmission transmission NN cord-316525-uadfehr6 98 38 among among IN cord-316525-uadfehr6 98 39 the the DT cord-316525-uadfehr6 98 40 human human JJ cord-316525-uadfehr6 98 41 and and CC cord-316525-uadfehr6 98 42 animal animal NN cord-316525-uadfehr6 98 43 SARS SARS NNP cord-316525-uadfehr6 98 44 - - HYPH cord-316525-uadfehr6 98 45 CoV CoV NNP cord-316525-uadfehr6 98 46 - - HYPH cord-316525-uadfehr6 98 47 like like JJ cord-316525-uadfehr6 98 48 viruses virus NNS cord-316525-uadfehr6 98 49 had have VBD cord-316525-uadfehr6 98 50 occurred occur VBN cord-316525-uadfehr6 98 51 . . . cord-316525-uadfehr6 99 1 The the DT cord-316525-uadfehr6 99 2 mutation mutation NN cord-316525-uadfehr6 99 3 analysis analysis NN cord-316525-uadfehr6 99 4 of of IN cord-316525-uadfehr6 99 5 sequence sequence NN cord-316525-uadfehr6 99 6 variations variation NNS cord-316525-uadfehr6 99 7 among among IN cord-316525-uadfehr6 99 8 these these DT cord-316525-uadfehr6 99 9 isolates isolate NNS cord-316525-uadfehr6 99 10 will will MD cord-316525-uadfehr6 99 11 help help VB cord-316525-uadfehr6 99 12 identify identify VB cord-316525-uadfehr6 99 13 the the DT cord-316525-uadfehr6 99 14 genetic genetic JJ cord-316525-uadfehr6 99 15 signature signature NN cord-316525-uadfehr6 99 16 of of IN cord-316525-uadfehr6 99 17 SARS SARS NNP cord-316525-uadfehr6 99 18 virus virus NN cord-316525-uadfehr6 99 19 strains strain VBZ cord-316525-uadfehr6 99 20 when when WRB cord-316525-uadfehr6 99 21 a a DT cord-316525-uadfehr6 99 22 sufficient sufficient JJ cord-316525-uadfehr6 99 23 amount amount NN cord-316525-uadfehr6 99 24 of of IN cord-316525-uadfehr6 99 25 sequence sequence NN cord-316525-uadfehr6 99 26 data data NN cord-316525-uadfehr6 99 27 is be VBZ cord-316525-uadfehr6 99 28 available available JJ cord-316525-uadfehr6 99 29 . . . cord-316525-uadfehr6 100 1 The the DT cord-316525-uadfehr6 100 2 very very JJ cord-316525-uadfehr6 100 3 fact fact NN cord-316525-uadfehr6 100 4 that that IN cord-316525-uadfehr6 100 5 several several JJ cord-316525-uadfehr6 100 6 species specie NNS cord-316525-uadfehr6 100 7 of of IN cord-316525-uadfehr6 100 8 animals animal NNS cord-316525-uadfehr6 100 9 are be VBP cord-316525-uadfehr6 100 10 affected affect VBN cord-316525-uadfehr6 100 11 does do VBZ cord-316525-uadfehr6 100 12 not not RB cord-316525-uadfehr6 100 13 allow allow VB cord-316525-uadfehr6 100 14 one one CD cord-316525-uadfehr6 100 15 to to TO cord-316525-uadfehr6 100 16 trace trace VB cord-316525-uadfehr6 100 17 directly directly RB cord-316525-uadfehr6 100 18 the the DT cord-316525-uadfehr6 100 19 origin origin NN cord-316525-uadfehr6 100 20 of of IN cord-316525-uadfehr6 100 21 the the DT cord-316525-uadfehr6 100 22 virus virus NN cord-316525-uadfehr6 100 23 as as IN cord-316525-uadfehr6 100 24 endemic endemic JJ cord-316525-uadfehr6 100 25 in in IN cord-316525-uadfehr6 100 26 one one CD cord-316525-uadfehr6 100 27 of of IN cord-316525-uadfehr6 100 28 these these DT cord-316525-uadfehr6 100 29 species specie NNS cord-316525-uadfehr6 100 30 , , , cord-316525-uadfehr6 100 31 but but CC cord-316525-uadfehr6 100 32 , , , cord-316525-uadfehr6 100 33 rather rather RB cord-316525-uadfehr6 100 34 , , , cord-316525-uadfehr6 100 35 might may MD cord-316525-uadfehr6 100 36 be be VB cord-316525-uadfehr6 100 37 indicative indicative JJ cord-316525-uadfehr6 100 38 that that IN cord-316525-uadfehr6 100 39 animals animal NNS cord-316525-uadfehr6 100 40 and and CC cord-316525-uadfehr6 100 41 men man NNS cord-316525-uadfehr6 100 42 might may MD cord-316525-uadfehr6 100 43 have have VB cord-316525-uadfehr6 100 44 been be VBN cord-316525-uadfehr6 100 45 contaminated contaminate VBN cord-316525-uadfehr6 100 46 by by IN cord-316525-uadfehr6 100 47 a a DT cord-316525-uadfehr6 100 48 virus virus NN cord-316525-uadfehr6 100 49 from from IN cord-316525-uadfehr6 100 50 a a DT cord-316525-uadfehr6 100 51 common common JJ cord-316525-uadfehr6 100 52 origin origin NN cord-316525-uadfehr6 100 53 , , , cord-316525-uadfehr6 100 54 presumably presumably RB cord-316525-uadfehr6 100 55 located locate VBN cord-316525-uadfehr6 100 56 in in IN cord-316525-uadfehr6 100 57 animal animal NN cord-316525-uadfehr6 100 58 food food NN cord-316525-uadfehr6 100 59 present present JJ cord-316525-uadfehr6 100 60 in in IN cord-316525-uadfehr6 100 61 local local JJ cord-316525-uadfehr6 100 62 markets market NNS cord-316525-uadfehr6 100 63 in in IN cord-316525-uadfehr6 100 64 the the DT cord-316525-uadfehr6 100 65 Guangdong Guangdong NNP cord-316525-uadfehr6 100 66 province province NN cord-316525-uadfehr6 100 67 . . . cord-316525-uadfehr6 101 1 Investigating investigate VBG cord-316525-uadfehr6 101 2 a a DT cord-316525-uadfehr6 101 3 wide wide JJ cord-316525-uadfehr6 101 4 variety variety NN cord-316525-uadfehr6 101 5 of of IN cord-316525-uadfehr6 101 6 animal animal NN cord-316525-uadfehr6 101 7 coronaviruses coronaviruse NNS cord-316525-uadfehr6 101 8 , , , cord-316525-uadfehr6 101 9 especially especially RB cord-316525-uadfehr6 101 10 in in IN cord-316525-uadfehr6 101 11 relation relation NN cord-316525-uadfehr6 101 12 to to IN cord-316525-uadfehr6 101 13 rodents rodent NNS cord-316525-uadfehr6 101 14 , , , cord-316525-uadfehr6 101 15 birds bird NNS cord-316525-uadfehr6 101 16 , , , cord-316525-uadfehr6 101 17 snakes snake NNS cord-316525-uadfehr6 101 18 and and CC cord-316525-uadfehr6 101 19 farm farm NN cord-316525-uadfehr6 101 20 animals animal NNS cord-316525-uadfehr6 101 21 , , , cord-316525-uadfehr6 101 22 would would MD cord-316525-uadfehr6 101 23 be be VB cord-316525-uadfehr6 101 24 interesting interesting JJ cord-316525-uadfehr6 101 25 with with IN cord-316525-uadfehr6 101 26 regard regard NN cord-316525-uadfehr6 101 27 to to IN cord-316525-uadfehr6 101 28 the the DT cord-316525-uadfehr6 101 29 origin origin NN cord-316525-uadfehr6 101 30 of of IN cord-316525-uadfehr6 101 31 the the DT cord-316525-uadfehr6 101 32 SARS SARS NNP cord-316525-uadfehr6 101 33 - - HYPH cord-316525-uadfehr6 101 34 CoV CoV NNP cord-316525-uadfehr6 101 35 that that WDT cord-316525-uadfehr6 101 36 caused cause VBD cord-316525-uadfehr6 101 37 disease disease NN cord-316525-uadfehr6 101 38 in in IN cord-316525-uadfehr6 101 39 humans human NNS cord-316525-uadfehr6 101 40 . . . cord-316525-uadfehr6 102 1 Finally finally RB cord-316525-uadfehr6 102 2 , , , cord-316525-uadfehr6 102 3 a a DT cord-316525-uadfehr6 102 4 challenging challenging JJ cord-316525-uadfehr6 102 5 question question NN cord-316525-uadfehr6 102 6 arises arise VBZ cord-316525-uadfehr6 102 7 . . . cord-316525-uadfehr6 103 1 What what WP cord-316525-uadfehr6 103 2 is be VBZ cord-316525-uadfehr6 103 3 the the DT cord-316525-uadfehr6 103 4 molecular molecular JJ cord-316525-uadfehr6 103 5 basis basis NN cord-316525-uadfehr6 103 6 of of IN cord-316525-uadfehr6 103 7 recombination recombination NN cord-316525-uadfehr6 103 8 in in IN cord-316525-uadfehr6 103 9 SARS SARS NNP cord-316525-uadfehr6 103 10 - - HYPH cord-316525-uadfehr6 103 11 CoV CoV NNP cord-316525-uadfehr6 103 12 ? ? . cord-316525-uadfehr6 104 1 Many many JJ cord-316525-uadfehr6 104 2 requirements requirement NNS cord-316525-uadfehr6 104 3 are be VBP cord-316525-uadfehr6 104 4 needed need VBN cord-316525-uadfehr6 104 5 for for IN cord-316525-uadfehr6 104 6 recombination recombination NN cord-316525-uadfehr6 104 7 to to TO cord-316525-uadfehr6 104 8 occur occur VB cord-316525-uadfehr6 104 9 : : : cord-316525-uadfehr6 104 10 ( ( -LRB- cord-316525-uadfehr6 104 11 1 1 LS cord-316525-uadfehr6 104 12 ) ) -RRB- cord-316525-uadfehr6 104 13 Two two CD cord-316525-uadfehr6 104 14 coronaviruses coronaviruse NNS cord-316525-uadfehr6 104 15 can can MD cord-316525-uadfehr6 104 16 infect infect VB cord-316525-uadfehr6 104 17 a a DT cord-316525-uadfehr6 104 18 host host NN cord-316525-uadfehr6 104 19 simultaneously simultaneously RB cord-316525-uadfehr6 104 20 and and CC cord-316525-uadfehr6 104 21 continue continue VBP cord-316525-uadfehr6 104 22 to to TO cord-316525-uadfehr6 104 23 replicate replicate VB cord-316525-uadfehr6 104 24 without without IN cord-316525-uadfehr6 104 25 interference interference NN cord-316525-uadfehr6 104 26 with with IN cord-316525-uadfehr6 104 27 each each DT cord-316525-uadfehr6 104 28 other other JJ cord-316525-uadfehr6 104 29 ; ; : cord-316525-uadfehr6 104 30 ( ( -LRB- cord-316525-uadfehr6 104 31 2 2 LS cord-316525-uadfehr6 104 32 ) ) -RRB- cord-316525-uadfehr6 104 33 Sufficient sufficient JJ cord-316525-uadfehr6 104 34 nucleotide nucleotide JJ cord-316525-uadfehr6 104 35 identity identity NN cord-316525-uadfehr6 104 36 between between IN cord-316525-uadfehr6 104 37 these these DT cord-316525-uadfehr6 104 38 genomes genome NNS cord-316525-uadfehr6 104 39 is be VBZ cord-316525-uadfehr6 104 40 essential essential JJ cord-316525-uadfehr6 104 41 for for IN cord-316525-uadfehr6 104 42 genome genome NN cord-316525-uadfehr6 104 43 - - HYPH cord-316525-uadfehr6 104 44 switching switching NN cord-316525-uadfehr6 104 45 to to TO cord-316525-uadfehr6 104 46 occur occur VB cord-316525-uadfehr6 104 47 during during IN cord-316525-uadfehr6 104 48 RNA RNA NNP cord-316525-uadfehr6 104 49 replication replication NN cord-316525-uadfehr6 104 50 ; ; , cord-316525-uadfehr6 104 51 ( ( -LRB- cord-316525-uadfehr6 104 52 3 3 LS cord-316525-uadfehr6 104 53 ) ) -RRB- cord-316525-uadfehr6 105 1 The the DT cord-316525-uadfehr6 105 2 proteins protein NNS cord-316525-uadfehr6 105 3 arising arise VBG cord-316525-uadfehr6 105 4 from from IN cord-316525-uadfehr6 105 5 recombination recombination NN cord-316525-uadfehr6 105 6 must must MD cord-316525-uadfehr6 105 7 be be VB cord-316525-uadfehr6 105 8 functional functional JJ cord-316525-uadfehr6 105 9 ; ; : cord-316525-uadfehr6 105 10 ( ( -LRB- cord-316525-uadfehr6 105 11 4 4 LS cord-316525-uadfehr6 105 12 ) ) -RRB- cord-316525-uadfehr6 106 1 The the DT cord-316525-uadfehr6 106 2 recombinant recombinant JJ cord-316525-uadfehr6 106 3 virus virus NN cord-316525-uadfehr6 106 4 must must MD cord-316525-uadfehr6 106 5 have have VB cord-316525-uadfehr6 106 6 some some DT cord-316525-uadfehr6 106 7 selective selective JJ cord-316525-uadfehr6 106 8 advantage advantage NN cord-316525-uadfehr6 106 9 for for IN cord-316525-uadfehr6 106 10 its -PRON- PRP$ cord-316525-uadfehr6 106 11 survival survival NN cord-316525-uadfehr6 106 12 . . . cord-316525-uadfehr6 107 1 That that RB cord-316525-uadfehr6 107 2 is is RB cord-316525-uadfehr6 107 3 , , , cord-316525-uadfehr6 107 4 the the DT cord-316525-uadfehr6 107 5 recombination recombination NN cord-316525-uadfehr6 107 6 that that WDT cord-316525-uadfehr6 107 7 creates create VBZ cord-316525-uadfehr6 107 8 a a DT cord-316525-uadfehr6 107 9 successful successful JJ cord-316525-uadfehr6 107 10 " " `` cord-316525-uadfehr6 107 11 new new JJ cord-316525-uadfehr6 107 12 " " '' cord-316525-uadfehr6 107 13 coronavirus coronavirus NN cord-316525-uadfehr6 107 14 is be VBZ cord-316525-uadfehr6 107 15 probably probably RB cord-316525-uadfehr6 107 16 a a DT cord-316525-uadfehr6 107 17 rare rare JJ cord-316525-uadfehr6 107 18 event event NN cord-316525-uadfehr6 107 19 . . . cord-316525-uadfehr6 108 1 So so RB cord-316525-uadfehr6 108 2 , , , cord-316525-uadfehr6 108 3 we -PRON- PRP cord-316525-uadfehr6 108 4 must must MD cord-316525-uadfehr6 108 5 stress stress VB cord-316525-uadfehr6 108 6 that that IN cord-316525-uadfehr6 108 7 the the DT cord-316525-uadfehr6 108 8 potential potential JJ cord-316525-uadfehr6 108 9 recombination recombination NN cord-316525-uadfehr6 108 10 events event NNS cord-316525-uadfehr6 108 11 in in IN cord-316525-uadfehr6 108 12 SARS SARS NNP cord-316525-uadfehr6 108 13 - - HYPH cord-316525-uadfehr6 108 14 CoV CoV NNP cord-316525-uadfehr6 108 15 , , , cord-316525-uadfehr6 108 16 identified identify VBN cord-316525-uadfehr6 108 17 in in IN cord-316525-uadfehr6 108 18 the the DT cord-316525-uadfehr6 108 19 present present JJ cord-316525-uadfehr6 108 20 study study NN cord-316525-uadfehr6 108 21 , , , cord-316525-uadfehr6 108 22 are be VBP cord-316525-uadfehr6 108 23 most most RBS cord-316525-uadfehr6 108 24 likely likely JJ cord-316525-uadfehr6 108 25 " " `` cord-316525-uadfehr6 108 26 old old JJ cord-316525-uadfehr6 108 27 " " '' cord-316525-uadfehr6 108 28 events event NNS cord-316525-uadfehr6 108 29 , , , cord-316525-uadfehr6 108 30 which which WDT cord-316525-uadfehr6 108 31 may may MD cord-316525-uadfehr6 108 32 represent represent VB cord-316525-uadfehr6 108 33 the the DT cord-316525-uadfehr6 108 34 events event NNS cord-316525-uadfehr6 108 35 that that WDT cord-316525-uadfehr6 108 36 occurred occur VBD cord-316525-uadfehr6 108 37 thousands thousand NNS cord-316525-uadfehr6 108 38 of of IN cord-316525-uadfehr6 108 39 years year NNS cord-316525-uadfehr6 108 40 ago ago RB cord-316525-uadfehr6 108 41 . . . cord-316525-uadfehr6 109 1 Although although IN cord-316525-uadfehr6 109 2 the the DT cord-316525-uadfehr6 109 3 recent recent JJ cord-316525-uadfehr6 109 4 findings finding NNS cord-316525-uadfehr6 109 5 indicated indicate VBD cord-316525-uadfehr6 109 6 that that IN cord-316525-uadfehr6 109 7 SARS SARS NNP cord-316525-uadfehr6 109 8 - - HYPH cord-316525-uadfehr6 109 9 CoV CoV NNP cord-316525-uadfehr6 109 10 did do VBD cord-316525-uadfehr6 109 11 exist exist VB cord-316525-uadfehr6 109 12 in in IN cord-316525-uadfehr6 109 13 a a DT cord-316525-uadfehr6 109 14 number number NN cord-316525-uadfehr6 109 15 of of IN cord-316525-uadfehr6 109 16 wild wild JJ cord-316525-uadfehr6 109 17 animals animal NNS cord-316525-uadfehr6 109 18 [ [ -LRB- cord-316525-uadfehr6 109 19 7 7 CD cord-316525-uadfehr6 109 20 ] ] -RRB- cord-316525-uadfehr6 109 21 , , , cord-316525-uadfehr6 109 22 we -PRON- PRP cord-316525-uadfehr6 109 23 have have VBP cord-316525-uadfehr6 109 24 not not RB cord-316525-uadfehr6 109 25 yet yet RB cord-316525-uadfehr6 109 26 determined determine VBN cord-316525-uadfehr6 109 27 where where WRB cord-316525-uadfehr6 109 28 these these DT cord-316525-uadfehr6 109 29 SARS SARS NNP cord-316525-uadfehr6 109 30 - - HYPH cord-316525-uadfehr6 109 31 CoV CoV NNP cord-316525-uadfehr6 109 32 - - HYPH cord-316525-uadfehr6 109 33 like like JJ cord-316525-uadfehr6 109 34 virus virus NN cord-316525-uadfehr6 109 35 strains strain NNS cord-316525-uadfehr6 109 36 come come VBP cord-316525-uadfehr6 109 37 from from IN cord-316525-uadfehr6 109 38 . . . cord-316525-uadfehr6 110 1 Coronavirus Coronavirus NNP cord-316525-uadfehr6 110 2 main main JJ cord-316525-uadfehr6 110 3 proteinase proteinase NN cord-316525-uadfehr6 110 4 ( ( -LRB- cord-316525-uadfehr6 110 5 3CL 3CL NNP cord-316525-uadfehr6 110 6 pro pro JJ cord-316525-uadfehr6 110 7 ) ) -RRB- cord-316525-uadfehr6 110 8 structure structure NN cord-316525-uadfehr6 110 9 : : : cord-316525-uadfehr6 110 10 basis basis NN cord-316525-uadfehr6 110 11 for for IN cord-316525-uadfehr6 110 12 design design NN cord-316525-uadfehr6 110 13 of of IN cord-316525-uadfehr6 110 14 anti anti JJ cord-316525-uadfehr6 110 15 - - JJ cord-316525-uadfehr6 110 16 SARS SARS NNP cord-316525-uadfehr6 110 17 drugs drug NNS cord-316525-uadfehr6 110 18 Testing test VBG cord-316525-uadfehr6 110 19 the the DT cord-316525-uadfehr6 110 20 hypothesis hypothesis NN cord-316525-uadfehr6 110 21 of of IN cord-316525-uadfehr6 110 22 a a DT cord-316525-uadfehr6 110 23 recombinant recombinant JJ cord-316525-uadfehr6 110 24 origin origin NN cord-316525-uadfehr6 110 25 of of IN cord-316525-uadfehr6 110 26 human human JJ cord-316525-uadfehr6 110 27 immunodeficiency immunodeficiency NN cord-316525-uadfehr6 110 28 virus virus NN cord-316525-uadfehr6 110 29 type type NN cord-316525-uadfehr6 110 30 1 1 CD cord-316525-uadfehr6 110 31 subtype subtype NN cord-316525-uadfehr6 110 32 E e NN cord-316525-uadfehr6 110 33 Full full JJ cord-316525-uadfehr6 110 34 - - HYPH cord-316525-uadfehr6 110 35 length length NN cord-316525-uadfehr6 110 36 sequence sequence NN cord-316525-uadfehr6 110 37 and and CC cord-316525-uadfehr6 110 38 mosaic mosaic JJ cord-316525-uadfehr6 110 39 structure structure NN cord-316525-uadfehr6 110 40 of of IN cord-316525-uadfehr6 110 41 a a DT cord-316525-uadfehr6 110 42 human human JJ cord-316525-uadfehr6 110 43 immunodeficiency immunodeficiency NN cord-316525-uadfehr6 110 44 virus virus NN cord-316525-uadfehr6 110 45 type type NN cord-316525-uadfehr6 110 46 1 1 CD cord-316525-uadfehr6 110 47 isolate isolate VBP cord-316525-uadfehr6 110 48 from from IN cord-316525-uadfehr6 110 49 Thailand Thailand NNP cord-316525-uadfehr6 110 50 Evolution Evolution NNP cord-316525-uadfehr6 110 51 of of IN cord-316525-uadfehr6 110 52 avian avian JJ cord-316525-uadfehr6 110 53 coronavirus coronavirus NN cord-316525-uadfehr6 110 54 IBV IBV NNP cord-316525-uadfehr6 110 55 : : : cord-316525-uadfehr6 110 56 sequence sequence NN cord-316525-uadfehr6 110 57 of of IN cord-316525-uadfehr6 110 58 the the DT cord-316525-uadfehr6 110 59 matrix matrix NN cord-316525-uadfehr6 110 60 glycoprotein glycoprotein NN cord-316525-uadfehr6 110 61 gene gene NN cord-316525-uadfehr6 110 62 and and CC cord-316525-uadfehr6 110 63 intergenic intergenic JJ cord-316525-uadfehr6 110 64 region region NN cord-316525-uadfehr6 110 65 of of IN cord-316525-uadfehr6 110 66 several several JJ cord-316525-uadfehr6 110 67 serotypes serotype NNS cord-316525-uadfehr6 110 68 Infectious infectious JJ cord-316525-uadfehr6 110 69 bronchitis bronchitis NN cord-316525-uadfehr6 110 70 virus virus NN cord-316525-uadfehr6 110 71 : : : cord-316525-uadfehr6 110 72 evidence evidence NN cord-316525-uadfehr6 110 73 for for IN cord-316525-uadfehr6 110 74 recombination recombination NN cord-316525-uadfehr6 110 75 within within IN cord-316525-uadfehr6 110 76 the the DT cord-316525-uadfehr6 110 77 Massachusetts Massachusetts NNP cord-316525-uadfehr6 110 78 serotype serotype NN cord-316525-uadfehr6 111 1 The the DT cord-316525-uadfehr6 111 2 heterosexual heterosexual JJ cord-316525-uadfehr6 111 3 human human JJ cord-316525-uadfehr6 111 4 immunodeficiency immunodeficiency NN cord-316525-uadfehr6 111 5 virus virus NN cord-316525-uadfehr6 111 6 type type NN cord-316525-uadfehr6 111 7 1 1 CD cord-316525-uadfehr6 111 8 epidemic epidemic NN cord-316525-uadfehr6 111 9 in in IN cord-316525-uadfehr6 111 10 Thailand Thailand NNP cord-316525-uadfehr6 111 11 is be VBZ cord-316525-uadfehr6 111 12 caused cause VBN cord-316525-uadfehr6 111 13 by by IN cord-316525-uadfehr6 111 14 an an DT cord-316525-uadfehr6 111 15 intersubtype intersubtype NN cord-316525-uadfehr6 111 16 ( ( -LRB- cord-316525-uadfehr6 111 17 A a NN cord-316525-uadfehr6 111 18 / / SYM cord-316525-uadfehr6 111 19 E e NN cord-316525-uadfehr6 111 20 ) ) -RRB- cord-316525-uadfehr6 111 21 recombinant recombinant NN cord-316525-uadfehr6 111 22 of of IN cord-316525-uadfehr6 111 23 African african JJ cord-316525-uadfehr6 111 24 origin origin NN cord-316525-uadfehr6 111 25 Isolation isolation NN cord-316525-uadfehr6 111 26 and and CC cord-316525-uadfehr6 111 27 characterization characterization NN cord-316525-uadfehr6 111 28 of of IN cord-316525-uadfehr6 111 29 viruses virus NNS cord-316525-uadfehr6 111 30 related relate VBN cord-316525-uadfehr6 111 31 to to IN cord-316525-uadfehr6 111 32 the the DT cord-316525-uadfehr6 111 33 SARS SARS NNP cord-316525-uadfehr6 111 34 coronavirus coronavirus NN cord-316525-uadfehr6 111 35 from from IN cord-316525-uadfehr6 111 36 animals animal NNS cord-316525-uadfehr6 111 37 in in IN cord-316525-uadfehr6 111 38 southern southern JJ cord-316525-uadfehr6 111 39 China China NNP cord-316525-uadfehr6 111 40 Detecting detect VBG cord-316525-uadfehr6 111 41 recombination recombination NN cord-316525-uadfehr6 111 42 with with IN cord-316525-uadfehr6 111 43 MCMC MCMC NNP cord-316525-uadfehr6 111 44 Probabilistic Probabilistic NNP cord-316525-uadfehr6 111 45 divergence divergence NN cord-316525-uadfehr6 111 46 measures measure NNS cord-316525-uadfehr6 111 47 for for IN cord-316525-uadfehr6 111 48 detecting detect VBG cord-316525-uadfehr6 111 49 interspecies interspecie NNS cord-316525-uadfehr6 111 50 recombination recombination NN cord-316525-uadfehr6 112 1 A a DT cord-316525-uadfehr6 112 2 novel novel JJ cord-316525-uadfehr6 112 3 variant variant NN cord-316525-uadfehr6 112 4 of of IN cord-316525-uadfehr6 112 5 avian avian JJ cord-316525-uadfehr6 112 6 infectious infectious JJ cord-316525-uadfehr6 112 7 bronchitis bronchitis NN cord-316525-uadfehr6 112 8 virus virus NN cord-316525-uadfehr6 112 9 resulting result VBG cord-316525-uadfehr6 112 10 from from IN cord-316525-uadfehr6 112 11 recombination recombination NN cord-316525-uadfehr6 112 12 among among IN cord-316525-uadfehr6 112 13 three three CD cord-316525-uadfehr6 112 14 different different JJ cord-316525-uadfehr6 112 15 strains strain NNS cord-316525-uadfehr6 112 16 Experimental experimental JJ cord-316525-uadfehr6 112 17 evidence evidence NN cord-316525-uadfehr6 112 18 of of IN cord-316525-uadfehr6 112 19 recombination recombination NN cord-316525-uadfehr6 112 20 in in IN cord-316525-uadfehr6 112 21 coronavirus coronavirus NN cord-316525-uadfehr6 112 22 infectious infectious JJ cord-316525-uadfehr6 112 23 bronchitis bronchitis NN cord-316525-uadfehr6 112 24 virus virus NN cord-316525-uadfehr6 112 25 A a DT cord-316525-uadfehr6 112 26 novel novel JJ cord-316525-uadfehr6 112 27 coronavirus coronavirus NN cord-316525-uadfehr6 112 28 associated associate VBN cord-316525-uadfehr6 112 29 with with IN cord-316525-uadfehr6 112 30 severe severe JJ cord-316525-uadfehr6 112 31 acute acute JJ cord-316525-uadfehr6 112 32 respiratory respiratory JJ cord-316525-uadfehr6 112 33 syndrome syndrome NN cord-316525-uadfehr6 112 34 RNA RNA NNP cord-316525-uadfehr6 112 35 recombination recombination NN cord-316525-uadfehr6 112 36 in in IN cord-316525-uadfehr6 112 37 animal animal NN cord-316525-uadfehr6 112 38 and and CC cord-316525-uadfehr6 112 39 plant plant NN cord-316525-uadfehr6 112 40 viruses virus NNS cord-316525-uadfehr6 112 41 Recombination recombination VBP cord-316525-uadfehr6 112 42 in in IN cord-316525-uadfehr6 112 43 large large JJ cord-316525-uadfehr6 112 44 RNA RNA NNP cord-316525-uadfehr6 112 45 viruses virus NNS cord-316525-uadfehr6 112 46 : : : cord-316525-uadfehr6 112 47 coronaviruses coronaviruses NNP cord-316525-uadfehr6 112 48 Transmission Transmission NNP cord-316525-uadfehr6 112 49 dynamics dynamic NNS cord-316525-uadfehr6 112 50 and and CC cord-316525-uadfehr6 112 51 control control NN cord-316525-uadfehr6 112 52 of of IN cord-316525-uadfehr6 112 53 severe severe JJ cord-316525-uadfehr6 112 54 acute acute JJ cord-316525-uadfehr6 112 55 respiratory respiratory JJ cord-316525-uadfehr6 112 56 syndrome syndrome NN cord-316525-uadfehr6 112 57 High high JJ cord-316525-uadfehr6 112 58 - - HYPH cord-316525-uadfehr6 112 59 frequency frequency NN cord-316525-uadfehr6 112 60 RNA RNA NNP cord-316525-uadfehr6 112 61 recombination recombination NN cord-316525-uadfehr6 112 62 of of IN cord-316525-uadfehr6 112 63 murine murine JJ cord-316525-uadfehr6 112 64 coronaviruses coronaviruse NNS cord-316525-uadfehr6 113 1 The the DT cord-316525-uadfehr6 113 2 genome genome NN cord-316525-uadfehr6 113 3 sequence sequence NN cord-316525-uadfehr6 113 4 of of IN cord-316525-uadfehr6 113 5 the the DT cord-316525-uadfehr6 113 6 SARSassociated sarsassociated JJ cord-316525-uadfehr6 113 7 coronavirus coronavirus NN cord-316525-uadfehr6 113 8 RDP rdp NN cord-316525-uadfehr6 113 9 : : : cord-316525-uadfehr6 113 10 detection detection NN cord-316525-uadfehr6 113 11 of of IN cord-316525-uadfehr6 113 12 recombination recombination NN cord-316525-uadfehr6 113 13 amongst amongst IN cord-316525-uadfehr6 113 14 aligned align VBN cord-316525-uadfehr6 113 15 sequences sequence NNS cord-316525-uadfehr6 113 16 Analyzing analyze VBG cord-316525-uadfehr6 113 17 the the DT cord-316525-uadfehr6 113 18 mosaic mosaic JJ cord-316525-uadfehr6 113 19 structure structure NN cord-316525-uadfehr6 113 20 of of IN cord-316525-uadfehr6 113 21 genes gene NNS cord-316525-uadfehr6 114 1 A a DT cord-316525-uadfehr6 114 2 graphical graphical JJ cord-316525-uadfehr6 114 3 method method NN cord-316525-uadfehr6 114 4 for for IN cord-316525-uadfehr6 114 5 detecting detect VBG cord-316525-uadfehr6 114 6 recombination recombination NN cord-316525-uadfehr6 114 7 in in IN cord-316525-uadfehr6 114 8 phylogenetic phylogenetic JJ cord-316525-uadfehr6 114 9 data datum NNS cord-316525-uadfehr6 114 10 sets set VBZ cord-316525-uadfehr6 114 11 Recombination Recombination NNP cord-316525-uadfehr6 114 12 in in IN cord-316525-uadfehr6 114 13 the the DT cord-316525-uadfehr6 114 14 ompA ompa JJ cord-316525-uadfehr6 114 15 gene gene NN cord-316525-uadfehr6 114 16 but but CC cord-316525-uadfehr6 114 17 not not RB cord-316525-uadfehr6 114 18 the the DT cord-316525-uadfehr6 114 19 omcB omcb CD cord-316525-uadfehr6 114 20 gene gene NN cord-316525-uadfehr6 114 21 of of IN cord-316525-uadfehr6 114 22 Chlamydia Chlamydia NNP cord-316525-uadfehr6 114 23 contributes contribute VBZ cord-316525-uadfehr6 114 24 to to IN cord-316525-uadfehr6 114 25 serovar serovar NN cord-316525-uadfehr6 114 26 - - HYPH cord-316525-uadfehr6 114 27 specific specific JJ cord-316525-uadfehr6 114 28 differences difference NNS cord-316525-uadfehr6 114 29 in in IN cord-316525-uadfehr6 114 30 tissue tissue NN cord-316525-uadfehr6 114 31 tropism tropism NN cord-316525-uadfehr6 114 32 , , , cord-316525-uadfehr6 114 33 immune immune JJ cord-316525-uadfehr6 114 34 surveillance surveillance NN cord-316525-uadfehr6 114 35 , , , cord-316525-uadfehr6 114 36 and and CC cord-316525-uadfehr6 114 37 persistence persistence NN cord-316525-uadfehr6 114 38 of of IN cord-316525-uadfehr6 114 39 the the DT cord-316525-uadfehr6 114 40 organism organism NN cord-316525-uadfehr6 115 1 A a DT cord-316525-uadfehr6 115 2 double double JJ cord-316525-uadfehr6 115 3 epidemic epidemic NN cord-316525-uadfehr6 115 4 model model NN cord-316525-uadfehr6 115 5 for for IN cord-316525-uadfehr6 115 6 the the DT cord-316525-uadfehr6 115 7 SARS SARS NNP cord-316525-uadfehr6 115 8 propagation propagation NN cord-316525-uadfehr6 115 9 Evaluation Evaluation NNP cord-316525-uadfehr6 115 10 of of IN cord-316525-uadfehr6 115 11 methods method NNS cord-316525-uadfehr6 115 12 for for IN cord-316525-uadfehr6 115 13 detecting detect VBG cord-316525-uadfehr6 115 14 recombination recombination NN cord-316525-uadfehr6 115 15 from from IN cord-316525-uadfehr6 115 16 DNA dna NN cord-316525-uadfehr6 115 17 sequences sequence NNS cord-316525-uadfehr6 115 18 : : : cord-316525-uadfehr6 115 19 Empirical empirical JJ cord-316525-uadfehr6 115 20 data datum NNS cord-316525-uadfehr6 115 21 Evaluation Evaluation NNP cord-316525-uadfehr6 115 22 of of IN cord-316525-uadfehr6 115 23 methods method NNS cord-316525-uadfehr6 115 24 for for IN cord-316525-uadfehr6 115 25 detecting detect VBG cord-316525-uadfehr6 115 26 recombination recombination NN cord-316525-uadfehr6 115 27 from from IN cord-316525-uadfehr6 115 28 DNA dna NN cord-316525-uadfehr6 115 29 sequences sequence NNS cord-316525-uadfehr6 115 30 : : : cord-316525-uadfehr6 116 1 Computer computer NN cord-316525-uadfehr6 116 2 simulations simulation NNS cord-316525-uadfehr6 116 3 Characterization characterization NN cord-316525-uadfehr6 116 4 of of IN cord-316525-uadfehr6 116 5 a a DT cord-316525-uadfehr6 116 6 novel novel JJ cord-316525-uadfehr6 116 7 coronavirus coronavirus NN cord-316525-uadfehr6 116 8 associated associate VBN cord-316525-uadfehr6 116 9 with with IN cord-316525-uadfehr6 116 10 severe severe JJ cord-316525-uadfehr6 116 11 acute acute JJ cord-316525-uadfehr6 116 12 respiratory respiratory JJ cord-316525-uadfehr6 116 13 syndrome syndrome NN cord-316525-uadfehr6 116 14 Identification identification NN cord-316525-uadfehr6 116 15 of of IN cord-316525-uadfehr6 116 16 breakpoints breakpoint NNS cord-316525-uadfehr6 116 17 in in IN cord-316525-uadfehr6 116 18 intergenotypic intergenotypic JJ cord-316525-uadfehr6 116 19 recombinants recombinant NNS cord-316525-uadfehr6 116 20 of of IN cord-316525-uadfehr6 116 21 HIV HIV NNP cord-316525-uadfehr6 116 22 type type NN cord-316525-uadfehr6 116 23 1 1 CD cord-316525-uadfehr6 116 24 by by IN cord-316525-uadfehr6 116 25 Bootscanning Bootscanning NNP cord-316525-uadfehr6 116 26 A a DT cord-316525-uadfehr6 116 27 new new JJ cord-316525-uadfehr6 116 28 model model NN cord-316525-uadfehr6 116 29 for for IN cord-316525-uadfehr6 116 30 coronavirus coronavirus NN cord-316525-uadfehr6 116 31 transcription transcription NN cord-316525-uadfehr6 116 32 Statistical statistical JJ cord-316525-uadfehr6 116 33 tests test NNS cord-316525-uadfehr6 116 34 for for IN cord-316525-uadfehr6 116 35 detecting detect VBG cord-316525-uadfehr6 116 36 gene gene NN cord-316525-uadfehr6 116 37 conversion conversion NN cord-316525-uadfehr6 116 38 Unique Unique NNP cord-316525-uadfehr6 116 39 and and CC cord-316525-uadfehr6 116 40 conserved conserve VBN cord-316525-uadfehr6 116 41 features feature NNS cord-316525-uadfehr6 116 42 of of IN cord-316525-uadfehr6 116 43 genome genome NN cord-316525-uadfehr6 116 44 and and CC cord-316525-uadfehr6 116 45 proteome proteome NN cord-316525-uadfehr6 116 46 of of IN cord-316525-uadfehr6 116 47 SARS SARS NNP cord-316525-uadfehr6 116 48 - - HYPH cord-316525-uadfehr6 116 49 coronavirus coronavirus NN cord-316525-uadfehr6 116 50 , , , cord-316525-uadfehr6 116 51 an an DT cord-316525-uadfehr6 116 52 early early JJ cord-316525-uadfehr6 116 53 split split NN cord-316525-uadfehr6 116 54 - - HYPH cord-316525-uadfehr6 116 55 off off NN cord-316525-uadfehr6 116 56 from from IN cord-316525-uadfehr6 116 57 the the DT cord-316525-uadfehr6 116 58 coronavirus coronavirus NN cord-316525-uadfehr6 116 59 group group NN cord-316525-uadfehr6 116 60 2 2 CD cord-316525-uadfehr6 116 61 lineage lineage NN cord-316525-uadfehr6 116 62 Comparison comparison NN cord-316525-uadfehr6 116 63 of of IN cord-316525-uadfehr6 116 64 the the DT cord-316525-uadfehr6 116 65 genome genome NN cord-316525-uadfehr6 116 66 organization organization NN cord-316525-uadfehr6 116 67 of of IN cord-316525-uadfehr6 116 68 toro toro NNP cord-316525-uadfehr6 116 69 - - HYPH cord-316525-uadfehr6 116 70 and and CC cord-316525-uadfehr6 116 71 coronaviruses coronaviruse NNS cord-316525-uadfehr6 116 72 : : : cord-316525-uadfehr6 116 73 evidence evidence NN cord-316525-uadfehr6 116 74 for for IN cord-316525-uadfehr6 116 75 two two CD cord-316525-uadfehr6 116 76 nonhomologous nonhomologous NNP cord-316525-uadfehr6 116 77 RNA RNA NNP cord-316525-uadfehr6 116 78 recombination recombination NN cord-316525-uadfehr6 116 79 events event NNS cord-316525-uadfehr6 116 80 during during IN cord-316525-uadfehr6 116 81 Berne Berne NNP cord-316525-uadfehr6 116 82 virus virus NN cord-316525-uadfehr6 116 83 evolution evolution NN cord-316525-uadfehr6 116 84 Transcription Transcription NNP cord-316525-uadfehr6 116 85 strategy strategy NN cord-316525-uadfehr6 116 86 of of IN cord-316525-uadfehr6 116 87 coronaviruses coronaviruse NNS cord-316525-uadfehr6 116 88 : : : cord-316525-uadfehr6 117 1 fusion fusion NN cord-316525-uadfehr6 117 2 of of IN cord-316525-uadfehr6 117 3 non non JJ cord-316525-uadfehr6 117 4 - - JJ cord-316525-uadfehr6 117 5 contiguous contiguous JJ cord-316525-uadfehr6 117 6 sequences sequence NNS cord-316525-uadfehr6 117 7 during during IN cord-316525-uadfehr6 117 8 mRNA mRNA NNP cord-316525-uadfehr6 117 9 synthesis synthesis NN cord-316525-uadfehr6 117 10 Mosaic Mosaic NNP cord-316525-uadfehr6 117 11 evolution evolution NN cord-316525-uadfehr6 117 12 of of IN cord-316525-uadfehr6 117 13 the the DT cord-316525-uadfehr6 117 14 severe severe JJ cord-316525-uadfehr6 117 15 acute acute JJ cord-316525-uadfehr6 117 16 respiratory respiratory JJ cord-316525-uadfehr6 117 17 syndrome syndrome NN cord-316525-uadfehr6 117 18 coronavirus coronavirus NN cord-316525-uadfehr6 117 19 CLUSTAL CLUSTAL NNP cord-316525-uadfehr6 117 20 W W NNP cord-316525-uadfehr6 117 21 : : : cord-316525-uadfehr6 117 22 improving improve VBG cord-316525-uadfehr6 117 23 the the DT cord-316525-uadfehr6 117 24 sensitivity sensitivity NN cord-316525-uadfehr6 117 25 of of IN cord-316525-uadfehr6 117 26 progressive progressive JJ cord-316525-uadfehr6 117 27 multiple multiple JJ cord-316525-uadfehr6 117 28 sequence sequence NN cord-316525-uadfehr6 117 29 alignment alignment NN cord-316525-uadfehr6 117 30 through through IN cord-316525-uadfehr6 117 31 sequence sequence NN cord-316525-uadfehr6 117 32 weighting weighting NN cord-316525-uadfehr6 117 33 , , , cord-316525-uadfehr6 117 34 positions position NNS cord-316525-uadfehr6 117 35 - - HYPH cord-316525-uadfehr6 117 36 specific specific JJ cord-316525-uadfehr6 117 37 gap gap NN cord-316525-uadfehr6 117 38 penalties penalty NNS cord-316525-uadfehr6 117 39 and and CC cord-316525-uadfehr6 117 40 weight weight NN cord-316525-uadfehr6 117 41 matrix matrix NN cord-316525-uadfehr6 117 42 choice choice NN cord-316525-uadfehr6 117 43 Regulation regulation NN cord-316525-uadfehr6 117 44 of of IN cord-316525-uadfehr6 117 45 transcription transcription NN cord-316525-uadfehr6 117 46 of of IN cord-316525-uadfehr6 117 47 coronaviruses coronaviruse NNS cord-316525-uadfehr6 117 48 Recombination Recombination NNP cord-316525-uadfehr6 117 49 in in IN cord-316525-uadfehr6 117 50 SARS SARS NNP cord-316525-uadfehr6 117 51 - - HYPH cord-316525-uadfehr6 117 52 CoV CoV NNP cord-316525-uadfehr6 117 53 Flood Flood NNP cord-316525-uadfehr6 117 54 of of IN cord-316525-uadfehr6 117 55 sequence sequence NN cord-316525-uadfehr6 117 56 data data NN cord-316525-uadfehr6 117 57 yields yield VBZ cord-316525-uadfehr6 117 58 clues clue NNS cord-316525-uadfehr6 117 59 but but CC cord-316525-uadfehr6 117 60 few few JJ cord-316525-uadfehr6 117 61 answers answer NNS cord-316525-uadfehr6 117 62 Evidence evidence NN cord-316525-uadfehr6 117 63 of of IN cord-316525-uadfehr6 117 64 natural natural JJ cord-316525-uadfehr6 117 65 recombination recombination NN cord-316525-uadfehr6 117 66 within within IN cord-316525-uadfehr6 117 67 the the DT cord-316525-uadfehr6 117 68 S1 S1 NNP cord-316525-uadfehr6 117 69 gene gene NN cord-316525-uadfehr6 117 70 of of IN cord-316525-uadfehr6 117 71 infectious infectious JJ cord-316525-uadfehr6 117 72 bronchitis bronchitis NN cord-316525-uadfehr6 117 73 virus virus NN cord-316525-uadfehr6 117 74 Evolutionary evolutionary JJ cord-316525-uadfehr6 117 75 implications implication NNS cord-316525-uadfehr6 117 76 of of IN cord-316525-uadfehr6 117 77 genetic genetic JJ cord-316525-uadfehr6 117 78 variations variation NNS cord-316525-uadfehr6 117 79 in in IN cord-316525-uadfehr6 117 80 the the DT cord-316525-uadfehr6 117 81 S1 S1 NNP cord-316525-uadfehr6 117 82 gene gene NN cord-316525-uadfehr6 117 83 of of IN cord-316525-uadfehr6 117 84 infectious infectious JJ cord-316525-uadfehr6 117 85 bronchitis bronchitis NN cord-316525-uadfehr6 117 86 virus virus NN cord-316525-uadfehr6 117 87 Experimental experimental JJ cord-316525-uadfehr6 117 88 confirmation confirmation NN cord-316525-uadfehr6 117 89 of of IN cord-316525-uadfehr6 117 90 recombination recombination NN cord-316525-uadfehr6 117 91 upstream upstream RB cord-316525-uadfehr6 117 92 of of IN cord-316525-uadfehr6 117 93 the the DT cord-316525-uadfehr6 117 94 S1 S1 NNP cord-316525-uadfehr6 117 95 hypervariable hypervariable NN cord-316525-uadfehr6 117 96 region region NN cord-316525-uadfehr6 117 97 of of IN cord-316525-uadfehr6 117 98 infectious infectious JJ cord-316525-uadfehr6 117 99 bronchitis bronchitis NN cord-316525-uadfehr6 117 100 virus virus NN cord-316525-uadfehr6 117 101 Widespread widespread JJ cord-316525-uadfehr6 117 102 intra intra JJ cord-316525-uadfehr6 117 103 - - JJ cord-316525-uadfehr6 117 104 serotype serotype JJ cord-316525-uadfehr6 117 105 recombination recombination NN cord-316525-uadfehr6 117 106 in in IN cord-316525-uadfehr6 117 107 natural natural JJ cord-316525-uadfehr6 117 108 populations population NNS cord-316525-uadfehr6 117 109 of of IN cord-316525-uadfehr6 117 110 dengue dengue NN cord-316525-uadfehr6 117 111 virus virus NN cord-316525-uadfehr6 118 1 Author author NN cord-316525-uadfehr6 118 2 's 's POS cord-316525-uadfehr6 118 3 address address NN cord-316525-uadfehr6 118 4 : : : cord-316525-uadfehr6 118 5 Dr Dr NNP cord-316525-uadfehr6 119 1 We -PRON- PRP cord-316525-uadfehr6 119 2 wish wish VBP cord-316525-uadfehr6 119 3 to to TO cord-316525-uadfehr6 119 4 thank thank VB cord-316525-uadfehr6 119 5 the the DT cord-316525-uadfehr6 119 6 Hong Hong NNP cord-316525-uadfehr6 119 7 Kong Kong NNP cord-316525-uadfehr6 119 8 Innovation Innovation NNP cord-316525-uadfehr6 119 9 and and CC cord-316525-uadfehr6 119 10 Technology Technology NNP cord-316525-uadfehr6 119 11 Fund Fund NNP cord-316525-uadfehr6 119 12 for for IN cord-316525-uadfehr6 119 13 supporting support VBG cord-316525-uadfehr6 119 14 the the DT cord-316525-uadfehr6 119 15 present present JJ cord-316525-uadfehr6 119 16 research research NN cord-316525-uadfehr6 119 17 . . . cord-316525-uadfehr6 120 1 Ending end VBG cord-316525-uadfehr6 120 2 in in IN cord-316525-uadfehr6 120 3 Length length NN cord-316525-uadfehr6 120 4 _SP cord-316525-uadfehr6 120 5 Identity Identity NNP cord-316525-uadfehr6 120 6 _SP cord-316525-uadfehr6 120 7 Match Match NNP cord-316525-uadfehr6 120 8 percent percent VB cord-316525-uadfehr6 120 9 _SP cord-316525-uadfehr6 121 1 Source source NN cord-316525-uadfehr6 121 2 _SP cord-316525-uadfehr6 121 3 SARS SARS NNP cord-316525-uadfehr6 121 4 _SP cord-316525-uadfehr6 122 1 SARS SARS NNP cord-316525-uadfehr6 122 2 _SP cord-316525-uadfehr6 122 3 ( ( -LRB- cord-316525-uadfehr6 122 4 % % NN cord-316525-uadfehr6 122 5 ) ) -RRB- cord-316525-uadfehr6 122 6 _SP cord-316525-uadfehr6 122 7 10063 10063 CD cord-316525-uadfehr6 122 8 _SP cord-316525-uadfehr6 123 1 10109 10109 CD cord-316525-uadfehr6 123 2 _SP cord-316525-uadfehr6 124 1 47 47 CD cord-316525-uadfehr6 124 2 _SP cord-316525-uadfehr6 125 1 41 41 CD cord-316525-uadfehr6 125 2 _SP cord-316525-uadfehr6 126 1 88 88 CD cord-316525-uadfehr6 126 2 _SP cord-316525-uadfehr6 126 3 MHV MHV NNP cord-316525-uadfehr6 126 4 _SP cord-316525-uadfehr6 127 1 10609 10609 CD cord-316525-uadfehr6 127 2 _SP cord-316525-uadfehr6 128 1 10641 10641 CD cord-316525-uadfehr6 128 2 _SP cord-316525-uadfehr6 129 1 33 33 CD cord-316525-uadfehr6 129 2 _SP cord-316525-uadfehr6 129 3 30 30 CD cord-316525-uadfehr6 129 4 _SP cord-316525-uadfehr6 129 5 91 91 CD cord-316525-uadfehr6 129 6 _SP cord-316525-uadfehr6 129 7 TGEV TGEV NNP cord-316525-uadfehr6 129 8 _SP cord-316525-uadfehr6 130 1 12821 12821 CD cord-316525-uadfehr6 130 2 _SP cord-316525-uadfehr6 131 1 12854 12854 CD cord-316525-uadfehr6 131 2 _SP cord-316525-uadfehr6 132 1 34 34 CD cord-316525-uadfehr6 132 2 _SP cord-316525-uadfehr6 132 3 31 31 CD cord-316525-uadfehr6 132 4 _SP cord-316525-uadfehr6 132 5 92 92 CD cord-316525-uadfehr6 132 6 _SP cord-316525-uadfehr6 133 1 HCoV HCoV NNP cord-316525-uadfehr6 133 2 _SP cord-316525-uadfehr6 133 3 13844 13844 CD cord-316525-uadfehr6 133 4 _SP cord-316525-uadfehr6 134 1 13879 13879 CD cord-316525-uadfehr6 134 2 _SP cord-316525-uadfehr6 135 1 36 36 CD cord-316525-uadfehr6 135 2 _SP cord-316525-uadfehr6 135 3 32 32 CD cord-316525-uadfehr6 135 4 _SP cord-316525-uadfehr6 136 1 89 89 CD cord-316525-uadfehr6 136 2 _SP cord-316525-uadfehr6 137 1 BCoV BCoV NNP cord-316525-uadfehr6 137 2 _SP cord-316525-uadfehr6 137 3 13845 13845 CD cord-316525-uadfehr6 137 4 _SP cord-316525-uadfehr6 138 1 13879 13879 CD cord-316525-uadfehr6 138 2 _SP cord-316525-uadfehr6 139 1 35 35 CD cord-316525-uadfehr6 139 2 IBV IBV NNP cord-316525-uadfehr6 139 3 _SP cord-316525-uadfehr6 140 1 14808 14808 CD cord-316525-uadfehr6 140 2 _SP cord-316525-uadfehr6 141 1 14835 14835 CD cord-316525-uadfehr6 141 2 _SP cord-316525-uadfehr6 142 1 28 28 CD cord-316525-uadfehr6 142 2 _SP cord-316525-uadfehr6 143 1 26 26 CD cord-316525-uadfehr6 143 2 _SP cord-316525-uadfehr6 144 1 93 93 CD cord-316525-uadfehr6 144 2 _SP cord-316525-uadfehr6 145 1 HCoV HCoV NNP cord-316525-uadfehr6 145 2 _SP cord-316525-uadfehr6 146 1 14913 14913 CD cord-316525-uadfehr6 146 2 _SP cord-316525-uadfehr6 147 1 14947 14947 CD cord-316525-uadfehr6 147 2 _SP cord-316525-uadfehr6 148 1 35 35 CD cord-316525-uadfehr6 148 2 _SP cord-316525-uadfehr6 148 3 31 31 CD cord-316525-uadfehr6 148 4 _SP cord-316525-uadfehr6 148 5 89 89 CD cord-316525-uadfehr6 148 6 _SP cord-316525-uadfehr6 149 1 HCoV HCoV NNP cord-316525-uadfehr6 149 2 _SP cord-316525-uadfehr6 150 1 14933 14933 CD cord-316525-uadfehr6 150 2 _SP cord-316525-uadfehr6 151 1 15070 15070 CD cord-316525-uadfehr6 151 2 _SP cord-316525-uadfehr6 152 1 138 138 CD cord-316525-uadfehr6 152 2 _SP cord-316525-uadfehr6 152 3 112 112 CD cord-316525-uadfehr6 152 4 _SP cord-316525-uadfehr6 153 1 82 82 CD cord-316525-uadfehr6 153 2 _SP cord-316525-uadfehr6 154 1 BCoV BCoV NNP cord-316525-uadfehr6 154 2 _SP cord-316525-uadfehr6 154 3 14982 14982 CD cord-316525-uadfehr6 154 4 _SP cord-316525-uadfehr6 155 1 15091 15091 CD cord-316525-uadfehr6 155 2 _SP cord-316525-uadfehr6 156 1 110 110 CD cord-316525-uadfehr6 156 2 _SP cord-316525-uadfehr6 157 1 89 89 CD cord-316525-uadfehr6 157 2 _SP cord-316525-uadfehr6 158 1 81 81 CD cord-316525-uadfehr6 158 2 _SP cord-316525-uadfehr6 158 3 IBV IBV NNP cord-316525-uadfehr6 158 4 _SP cord-316525-uadfehr6 158 5 14986 14986 CD cord-316525-uadfehr6 158 6 _SP cord-316525-uadfehr6 159 1 15055 15055 CD cord-316525-uadfehr6 159 2 _SP cord-316525-uadfehr6 160 1 70 70 CD cord-316525-uadfehr6 160 2 _SP cord-316525-uadfehr6 160 3 64 64 CD cord-316525-uadfehr6 160 4 _SP cord-316525-uadfehr6 160 5 92 92 CD cord-316525-uadfehr6 160 6 _SP cord-316525-uadfehr6 161 1 MHV MHV NNP cord-316525-uadfehr6 161 2 _SP cord-316525-uadfehr6 162 1 15062 15062 CD cord-316525-uadfehr6 162 2 _SP cord-316525-uadfehr6 163 1 15093 15093 CD cord-316525-uadfehr6 163 2 _SP cord-316525-uadfehr6 164 1 32 32 CD cord-316525-uadfehr6 164 2 _SP cord-316525-uadfehr6 165 1 29 29 CD cord-316525-uadfehr6 165 2 _SP cord-316525-uadfehr6 166 1 91 91 CD cord-316525-uadfehr6 166 2 _SP cord-316525-uadfehr6 167 1 HCoV HCoV NNP cord-316525-uadfehr6 167 2 _SP cord-316525-uadfehr6 168 1 15123 15123 CD cord-316525-uadfehr6 168 2 _SP cord-316525-uadfehr6 169 1 15173 15173 CD cord-316525-uadfehr6 169 2 _SP cord-316525-uadfehr6 170 1 51 51 CD cord-316525-uadfehr6 170 2 _SP cord-316525-uadfehr6 171 1 43 43 CD cord-316525-uadfehr6 171 2 _SP cord-316525-uadfehr6 172 1 85 85 CD cord-316525-uadfehr6 172 2 _SP cord-316525-uadfehr6 173 1 TGEV TGEV NNP cord-316525-uadfehr6 173 2 _SP cord-316525-uadfehr6 174 1 15210 15210 CD cord-316525-uadfehr6 174 2 _SP cord-316525-uadfehr6 175 1 15232 15232 CD cord-316525-uadfehr6 175 2 _SP cord-316525-uadfehr6 176 1 23 23 CD cord-316525-uadfehr6 176 2 _SP cord-316525-uadfehr6 177 1 22 22 CD cord-316525-uadfehr6 177 2 _SP cord-316525-uadfehr6 177 3 96 96 CD cord-316525-uadfehr6 177 4 _SP cord-316525-uadfehr6 177 5 PEDV PEDV NNP cord-316525-uadfehr6 177 6 _SP cord-316525-uadfehr6 178 1 15210 15210 CD cord-316525-uadfehr6 178 2 _SP cord-316525-uadfehr6 179 1 15238 15238 CD cord-316525-uadfehr6 179 2 _SP cord-316525-uadfehr6 180 1 29 29 CD cord-316525-uadfehr6 180 2 _SP cord-316525-uadfehr6 181 1 27 27 CD cord-316525-uadfehr6 181 2 _SP cord-316525-uadfehr6 182 1 94 94 CD cord-316525-uadfehr6 182 2 _SP cord-316525-uadfehr6 183 1 BCoV BCoV NNP cord-316525-uadfehr6 183 2 _SP cord-316525-uadfehr6 184 1 15210 15210 CD cord-316525-uadfehr6 184 2 _SP cord-316525-uadfehr6 185 1 15253 15253 CD cord-316525-uadfehr6 185 2 _SP cord-316525-uadfehr6 186 1 44 44 CD cord-316525-uadfehr6 186 2 _SP cord-316525-uadfehr6 187 1 40 40 CD cord-316525-uadfehr6 187 2 _SP cord-316525-uadfehr6 187 3 91 91 CD cord-316525-uadfehr6 187 4 _SP cord-316525-uadfehr6 188 1 IBV IBV NNP cord-316525-uadfehr6 188 2 _SP cord-316525-uadfehr6 189 1 15417 15417 CD cord-316525-uadfehr6 189 2 _SP cord-316525-uadfehr6 190 1 15482 15482 CD cord-316525-uadfehr6 190 2 _SP cord-316525-uadfehr6 191 1 66 66 CD cord-316525-uadfehr6 191 2 _SP cord-316525-uadfehr6 192 1 57 57 CD cord-316525-uadfehr6 192 2 _SP cord-316525-uadfehr6 192 3 87 87 CD cord-316525-uadfehr6 192 4 _SP cord-316525-uadfehr6 193 1 BCoV BCoV NNP cord-316525-uadfehr6 193 2 _SP cord-316525-uadfehr6 194 1 15417 15417 CD cord-316525-uadfehr6 194 2 _SP cord-316525-uadfehr6 195 1 15457 15457 CD cord-316525-uadfehr6 195 2 _SP cord-316525-uadfehr6 196 1 41 41 CD cord-316525-uadfehr6 196 2 _SP cord-316525-uadfehr6 197 1 37 37 CD cord-316525-uadfehr6 197 2 _SP cord-316525-uadfehr6 197 3 91 91 CD cord-316525-uadfehr6 197 4 _SP cord-316525-uadfehr6 198 1 IBV IBV NNP cord-316525-uadfehr6 198 2 _SP cord-316525-uadfehr6 199 1 15420 15420 CD cord-316525-uadfehr6 199 2 _SP cord-316525-uadfehr6 200 1 15479 15479 CD cord-316525-uadfehr6 200 2 _SP cord-316525-uadfehr6 201 1 63 63 CD cord-316525-uadfehr6 201 2 _SP cord-316525-uadfehr6 202 1 55 55 CD cord-316525-uadfehr6 202 2 _SP cord-316525-uadfehr6 203 1 88 88 CD cord-316525-uadfehr6 203 2 _SP cord-316525-uadfehr6 204 1 MHV MHV NNP cord-316525-uadfehr6 204 2 _SP cord-316525-uadfehr6 205 1 15611 15611 CD cord-316525-uadfehr6 205 2 _SP cord-316525-uadfehr6 206 1 15682 15682 CD cord-316525-uadfehr6 206 2 _SP cord-316525-uadfehr6 207 1 72 72 CD cord-316525-uadfehr6 207 2 _SP cord-316525-uadfehr6 207 3 64 64 CD cord-316525-uadfehr6 207 4 _SP cord-316525-uadfehr6 207 5 89 89 CD cord-316525-uadfehr6 207 6 _SP cord-316525-uadfehr6 207 7 PEDV PEDV NNP cord-316525-uadfehr6 207 8 _SP cord-316525-uadfehr6 208 1 15624 15624 CD cord-316525-uadfehr6 208 2 _SP cord-316525-uadfehr6 209 1 15670 15670 CD cord-316525-uadfehr6 209 2 _SP cord-316525-uadfehr6 210 1 47 47 CD cord-316525-uadfehr6 210 2 _SP cord-316525-uadfehr6 211 1 42 42 CD cord-316525-uadfehr6 211 2 _SP cord-316525-uadfehr6 212 1 90 90 CD cord-316525-uadfehr6 212 2 _SP cord-316525-uadfehr6 213 1 HCoV HCoV NNP cord-316525-uadfehr6 213 2 _SP cord-316525-uadfehr6 214 1 15633 15633 CD cord-316525-uadfehr6 214 2 _SP cord-316525-uadfehr6 215 1 15672 15672 CD cord-316525-uadfehr6 215 2 _SP cord-316525-uadfehr6 216 1 40 40 CD cord-316525-uadfehr6 216 2 _SP cord-316525-uadfehr6 216 3 35 35 CD cord-316525-uadfehr6 216 4 _SP cord-316525-uadfehr6 216 5 88 88 CD cord-316525-uadfehr6 216 6 _SP cord-316525-uadfehr6 217 1 TGEV TGEV NNP cord-316525-uadfehr6 217 2 _SP cord-316525-uadfehr6 218 1 15729 15729 CD cord-316525-uadfehr6 218 2 _SP cord-316525-uadfehr6 219 1 15770 15770 CD cord-316525-uadfehr6 219 2 _SP cord-316525-uadfehr6 220 1 42 42 CD cord-316525-uadfehr6 220 2 _SP cord-316525-uadfehr6 221 1 40 40 CD cord-316525-uadfehr6 221 2 _SP cord-316525-uadfehr6 222 1 96 96 CD cord-316525-uadfehr6 222 2 _SP cord-316525-uadfehr6 223 1 MHV MHV NNP cord-316525-uadfehr6 223 2 _SP cord-316525-uadfehr6 224 1 15765 15765 CD cord-316525-uadfehr6 224 2 _SP cord-316525-uadfehr6 225 1 15817 15817 CD cord-316525-uadfehr6 225 2 _SP cord-316525-uadfehr6 226 1 53 53 CD cord-316525-uadfehr6 226 2 _SP cord-316525-uadfehr6 227 1 46 46 CD cord-316525-uadfehr6 227 2 _SP cord-316525-uadfehr6 228 1 87 87 CD cord-316525-uadfehr6 228 2 _SP cord-316525-uadfehr6 229 1 HCoV HCoV NNP cord-316525-uadfehr6 229 2 _SP cord-316525-uadfehr6 230 1 15852 15852 CD cord-316525-uadfehr6 230 2 _SP cord-316525-uadfehr6 231 1 15908 15908 CD cord-316525-uadfehr6 231 2 _SP cord-316525-uadfehr6 231 3 57 57 CD cord-316525-uadfehr6 231 4 _SP cord-316525-uadfehr6 231 5 49 49 CD cord-316525-uadfehr6 231 6 _SP cord-316525-uadfehr6 232 1 86 86 CD cord-316525-uadfehr6 232 2 _SP cord-316525-uadfehr6 233 1 MHV MHV NNP cord-316525-uadfehr6 233 2 _SP cord-316525-uadfehr6 234 1 17088 17088 CD cord-316525-uadfehr6 234 2 _SP cord-316525-uadfehr6 235 1 17125 17125 CD cord-316525-uadfehr6 235 2 _SP cord-316525-uadfehr6 236 1 38 38 CD cord-316525-uadfehr6 236 2 _SP cord-316525-uadfehr6 237 1 35 35 CD cord-316525-uadfehr6 237 2 _SP cord-316525-uadfehr6 237 3 93 93 CD cord-316525-uadfehr6 237 4 _SP cord-316525-uadfehr6 238 1 IBV IBV NNP cord-316525-uadfehr6 238 2 _SP cord-316525-uadfehr6 239 1 17688 17688 CD cord-316525-uadfehr6 239 2 _SP cord-316525-uadfehr6 240 1 17714 17714 CD cord-316525-uadfehr6 240 2 _SP cord-316525-uadfehr6 241 1 27 27 CD cord-316525-uadfehr6 241 2 _SP cord-316525-uadfehr6 242 1 25 25 CD cord-316525-uadfehr6 242 2 _SP cord-316525-uadfehr6 243 1 93 93 CD cord-316525-uadfehr6 243 2 _SP cord-316525-uadfehr6 244 1 TGEV TGEV NNP cord-316525-uadfehr6 244 2 _SP cord-316525-uadfehr6 245 1 17757 17757 CD cord-316525-uadfehr6 245 2 _SP cord-316525-uadfehr6 246 1 17800 17800 CD cord-316525-uadfehr6 246 2 _SP cord-316525-uadfehr6 247 1 44 44 CD cord-316525-uadfehr6 247 2 _SP cord-316525-uadfehr6 248 1 39 39 CD cord-316525-uadfehr6 248 2 _SP cord-316525-uadfehr6 249 1 89 89 CD cord-316525-uadfehr6 249 2 _SP cord-316525-uadfehr6 249 3 PEDV PEDV NNP cord-316525-uadfehr6 249 4 _SP cord-316525-uadfehr6 250 1 17783 17783 CD cord-316525-uadfehr6 250 2 _SP cord-316525-uadfehr6 251 1 17809 17809 CD cord-316525-uadfehr6 251 2 _SP cord-316525-uadfehr6 252 1 27 27 CD cord-316525-uadfehr6 252 2 _SP cord-316525-uadfehr6 253 1 25 25 CD cord-316525-uadfehr6 253 2 _SP cord-316525-uadfehr6 253 3 93 93 CD cord-316525-uadfehr6 253 4 _SP cord-316525-uadfehr6 254 1 HCoV HCoV NNP cord-316525-uadfehr6 254 2 _SP cord-316525-uadfehr6 255 1 18558 18558 CD cord-316525-uadfehr6 255 2 _SP cord-316525-uadfehr6 256 1 18577 18577 CD cord-316525-uadfehr6 256 2 _SP cord-316525-uadfehr6 257 1 20 20 CD cord-316525-uadfehr6 257 2 _SP cord-316525-uadfehr6 257 3 20 20 CD cord-316525-uadfehr6 257 4 _SP cord-316525-uadfehr6 257 5 100 100 CD cord-316525-uadfehr6 257 6 _SP cord-316525-uadfehr6 258 1 PEDV PEDV NNP cord-316525-uadfehr6 258 2 _SP cord-316525-uadfehr6 259 1 18771 18771 CD cord-316525-uadfehr6 259 2 _SP cord-316525-uadfehr6 260 1 18847 18847 CD cord-316525-uadfehr6 260 2 _SP cord-316525-uadfehr6 261 1 77 77 CD cord-316525-uadfehr6 261 2 _SP cord-316525-uadfehr6 262 1 65 65 CD cord-316525-uadfehr6 262 2 _SP cord-316525-uadfehr6 262 3 85 85 CD cord-316525-uadfehr6 262 4 _SP cord-316525-uadfehr6 263 1 TGEV TGEV NNP cord-316525-uadfehr6 263 2 _SP cord-316525-uadfehr6 264 1 18784 18784 CD cord-316525-uadfehr6 264 2 _SP cord-316525-uadfehr6 265 1 18833 18833 CD cord-316525-uadfehr6 265 2 _SP cord-316525-uadfehr6 266 1 50 50 CD cord-316525-uadfehr6 266 2 _SP cord-316525-uadfehr6 267 1 44 44 CD cord-316525-uadfehr6 267 2 _SP cord-316525-uadfehr6 267 3 88 88 CD cord-316525-uadfehr6 267 4 _SP cord-316525-uadfehr6 268 1 HCoV HCoV NNP cord-316525-uadfehr6 268 2 _SP cord-316525-uadfehr6 269 1 19102 19102 CD cord-316525-uadfehr6 269 2 _SP cord-316525-uadfehr6 270 1 19132 19132 CD cord-316525-uadfehr6 270 2 _SP cord-316525-uadfehr6 271 1 31 31 CD cord-316525-uadfehr6 271 2 _SP cord-316525-uadfehr6 272 1 29 29 CD cord-316525-uadfehr6 272 2 _SP cord-316525-uadfehr6 272 3 94 94 CD cord-316525-uadfehr6 272 4 _SP cord-316525-uadfehr6 272 5 IBV IBV NNP cord-316525-uadfehr6 272 6 _SP cord-316525-uadfehr6 273 1 19113 19113 CD cord-316525-uadfehr6 273 2 _SP cord-316525-uadfehr6 274 1 19132 19132 CD cord-316525-uadfehr6 274 2 _SP cord-316525-uadfehr6 275 1 20 20 CD cord-316525-uadfehr6 275 2 _SP cord-316525-uadfehr6 275 3 20 20 CD cord-316525-uadfehr6 275 4 _SP cord-316525-uadfehr6 275 5 100 100 CD cord-316525-uadfehr6 275 6 _SP cord-316525-uadfehr6 276 1 HCoV HCoV NNP cord-316525-uadfehr6 276 2 _SP cord-316525-uadfehr6 277 1 19146 19146 CD cord-316525-uadfehr6 277 2 _SP cord-316525-uadfehr6 278 1 19252 19252 CD cord-316525-uadfehr6 278 2 _SP cord-316525-uadfehr6 278 3 107 107 CD cord-316525-uadfehr6 278 4 _SP cord-316525-uadfehr6 279 1 87 87 CD cord-316525-uadfehr6 279 2 _SP cord-316525-uadfehr6 280 1 82 82 CD cord-316525-uadfehr6 280 2 _SP cord-316525-uadfehr6 281 1 MHV MHV NNP cord-316525-uadfehr6 281 2 _SP cord-316525-uadfehr6 282 1 19201 19201 CD cord-316525-uadfehr6 282 2 _SP cord-316525-uadfehr6 282 3 19252 19252 CD cord-316525-uadfehr6 282 4 _SP cord-316525-uadfehr6 283 1 52 52 CD cord-316525-uadfehr6 283 2 _SP cord-316525-uadfehr6 284 1 45 45 CD cord-316525-uadfehr6 284 2 _SP cord-316525-uadfehr6 284 3 87 87 CD cord-316525-uadfehr6 284 4 _SP cord-316525-uadfehr6 285 1 IBV IBV NNP cord-316525-uadfehr6 285 2 _SP cord-316525-uadfehr6 285 3 19206 19206 CD cord-316525-uadfehr6 285 4 _SP cord-316525-uadfehr6 286 1 19253 19253 CD cord-316525-uadfehr6 286 2 _SP cord-316525-uadfehr6 287 1 48 48 CD cord-316525-uadfehr6 287 2 _SP cord-316525-uadfehr6 288 1 44 44 CD cord-316525-uadfehr6 288 2 _SP cord-316525-uadfehr6 288 3 92 92 CD cord-316525-uadfehr6 288 4 _SP cord-316525-uadfehr6 289 1 BCoV BCoV NNP cord-316525-uadfehr6 289 2 _SP cord-316525-uadfehr6 290 1 19396 19396 CD cord-316525-uadfehr6 290 2 _SP cord-316525-uadfehr6 291 1 19420 19420 CD cord-316525-uadfehr6 291 2 _SP cord-316525-uadfehr6 292 1 25 25 CD cord-316525-uadfehr6 292 2 _SP cord-316525-uadfehr6 293 1 24 24 CD cord-316525-uadfehr6 293 2 _SP cord-316525-uadfehr6 294 1 96 96 CD cord-316525-uadfehr6 294 2 _SP cord-316525-uadfehr6 295 1 MHV MHV NNP cord-316525-uadfehr6 295 2 _SP