id sid tid token lemma pos cord-346321-drhiqch0 1 1 key key NN cord-346321-drhiqch0 1 2 : : : cord-346321-drhiqch0 1 3 cord-346321-drhiqch0 cord-346321-drhiqch0 NN cord-346321-drhiqch0 1 4 authors author NNS cord-346321-drhiqch0 1 5 : : : cord-346321-drhiqch0 1 6 Hohdatsu Hohdatsu NNP cord-346321-drhiqch0 1 7 , , , cord-346321-drhiqch0 1 8 T. T. NNP cord-346321-drhiqch0 1 9 ; ; : cord-346321-drhiqch0 1 10 Tokunaga Tokunaga NNP cord-346321-drhiqch0 1 11 , , , cord-346321-drhiqch0 1 12 J. J. NNP cord-346321-drhiqch0 1 13 ; ; : cord-346321-drhiqch0 1 14 Koyama Koyama NNP cord-346321-drhiqch0 1 15 , , , cord-346321-drhiqch0 1 16 H. H. NNP cord-346321-drhiqch0 1 17 title title NN cord-346321-drhiqch0 1 18 : : : cord-346321-drhiqch0 2 1 The the DT cord-346321-drhiqch0 2 2 role role NN cord-346321-drhiqch0 2 3 of of IN cord-346321-drhiqch0 2 4 IgG IgG NNP cord-346321-drhiqch0 2 5 subclass subclass NN cord-346321-drhiqch0 2 6 of of IN cord-346321-drhiqch0 2 7 mouse mouse NN cord-346321-drhiqch0 2 8 monoclonal monoclonal JJ cord-346321-drhiqch0 2 9 antibodies antibody NNS cord-346321-drhiqch0 2 10 in in IN cord-346321-drhiqch0 2 11 antibody antibody NN cord-346321-drhiqch0 2 12 - - HYPH cord-346321-drhiqch0 2 13 dependent dependent JJ cord-346321-drhiqch0 2 14 enhancement enhancement NN cord-346321-drhiqch0 2 15 of of IN cord-346321-drhiqch0 2 16 feline feline JJ cord-346321-drhiqch0 2 17 infectious infectious JJ cord-346321-drhiqch0 2 18 peritonitis peritonitis NN cord-346321-drhiqch0 2 19 virus virus NN cord-346321-drhiqch0 2 20 infection infection NN cord-346321-drhiqch0 2 21 of of IN cord-346321-drhiqch0 2 22 feline feline JJ cord-346321-drhiqch0 2 23 macrophages macrophage NNS cord-346321-drhiqch0 2 24 date date NN cord-346321-drhiqch0 2 25 : : : cord-346321-drhiqch0 2 26 1994 1994 CD cord-346321-drhiqch0 2 27 journal journal NN cord-346321-drhiqch0 2 28 : : : cord-346321-drhiqch0 3 1 Arch arch JJ cord-346321-drhiqch0 3 2 Virol Virol NNP cord-346321-drhiqch0 3 3 DOI doi NN cord-346321-drhiqch0 3 4 : : : cord-346321-drhiqch0 4 1 10.1007 10.1007 CD cord-346321-drhiqch0 4 2 / / SYM cord-346321-drhiqch0 4 3 bf01310791 bf01310791 NN cord-346321-drhiqch0 4 4 sha sha NNP cord-346321-drhiqch0 4 5 : : : cord-346321-drhiqch0 4 6 8db7eb8850c737719c15a261a60da85651e19335 8db7eb8850c737719c15a261a60da85651e19335 CD cord-346321-drhiqch0 4 7 doc_id doc_id CD cord-346321-drhiqch0 4 8 : : : cord-346321-drhiqch0 4 9 346321 346321 CD cord-346321-drhiqch0 4 10 cord_uid cord_uid NNS cord-346321-drhiqch0 4 11 : : : cord-346321-drhiqch0 5 1 drhiqch0 drhiqch0 NNP cord-346321-drhiqch0 5 2 Antibody antibody NN cord-346321-drhiqch0 5 3 - - HYPH cord-346321-drhiqch0 5 4 dependent dependent JJ cord-346321-drhiqch0 5 5 enhancement enhancement NN cord-346321-drhiqch0 5 6 ( ( -LRB- cord-346321-drhiqch0 5 7 ADE ADE NNP cord-346321-drhiqch0 5 8 ) ) -RRB- cord-346321-drhiqch0 5 9 of of IN cord-346321-drhiqch0 5 10 feline feline JJ cord-346321-drhiqch0 5 11 infectious infectious JJ cord-346321-drhiqch0 5 12 peritonitis peritonitis NN cord-346321-drhiqch0 5 13 virus virus NN cord-346321-drhiqch0 5 14 ( ( -LRB- cord-346321-drhiqch0 5 15 FIPV FIPV NNS cord-346321-drhiqch0 5 16 ) ) -RRB- cord-346321-drhiqch0 5 17 infection infection NN cord-346321-drhiqch0 5 18 was be VBD cord-346321-drhiqch0 5 19 studied study VBN cord-346321-drhiqch0 5 20 in in IN cord-346321-drhiqch0 5 21 feline feline JJ cord-346321-drhiqch0 5 22 alveolar alveolar NN cord-346321-drhiqch0 5 23 macrophages macrophage NNS cord-346321-drhiqch0 5 24 and and CC cord-346321-drhiqch0 5 25 human human JJ cord-346321-drhiqch0 5 26 monocyte monocyte NNP cord-346321-drhiqch0 5 27 cell cell NN cord-346321-drhiqch0 5 28 line line NN cord-346321-drhiqch0 5 29 U937 U937 VBN cord-346321-drhiqch0 5 30 using use VBG cord-346321-drhiqch0 5 31 mouse mouse NN cord-346321-drhiqch0 5 32 neutralizing neutralize VBG cord-346321-drhiqch0 5 33 monoclonal monoclonal JJ cord-346321-drhiqch0 5 34 antibodies antibody NNS cord-346321-drhiqch0 5 35 ( ( -LRB- cord-346321-drhiqch0 5 36 MAbs MAbs NNP cord-346321-drhiqch0 5 37 ) ) -RRB- cord-346321-drhiqch0 5 38 directed direct VBD cord-346321-drhiqch0 5 39 to to IN cord-346321-drhiqch0 5 40 the the DT cord-346321-drhiqch0 5 41 spike spike NN cord-346321-drhiqch0 5 42 protein protein NN cord-346321-drhiqch0 5 43 of of IN cord-346321-drhiqch0 5 44 FIPV FIPV NNS cord-346321-drhiqch0 5 45 . . . cord-346321-drhiqch0 6 1 Even even RB cord-346321-drhiqch0 6 2 among among IN cord-346321-drhiqch0 6 3 the the DT cord-346321-drhiqch0 6 4 MAbs MAbs NNP cord-346321-drhiqch0 6 5 that that WDT cord-346321-drhiqch0 6 6 have have VBP cord-346321-drhiqch0 6 7 been be VBN cord-346321-drhiqch0 6 8 shown show VBN cord-346321-drhiqch0 6 9 to to TO cord-346321-drhiqch0 6 10 recognize recognize VB cord-346321-drhiqch0 6 11 the the DT cord-346321-drhiqch0 6 12 same same JJ cord-346321-drhiqch0 6 13 antigenic antigenic JJ cord-346321-drhiqch0 6 14 site site NN cord-346321-drhiqch0 6 15 , , , cord-346321-drhiqch0 6 16 IgG IgG NNP cord-346321-drhiqch0 6 17 2a 2a NNP cord-346321-drhiqch0 6 18 MAbs MAbs NNP cord-346321-drhiqch0 6 19 enhanced enhance VBD cord-346321-drhiqch0 6 20 FIPV FIPV NNS cord-346321-drhiqch0 6 21 infection infection NN cord-346321-drhiqch0 6 22 strongly strongly RB cord-346321-drhiqch0 6 23 , , , cord-346321-drhiqch0 6 24 whereas whereas IN cord-346321-drhiqch0 6 25 IgG IgG NNP cord-346321-drhiqch0 6 26 1 1 CD cord-346321-drhiqch0 6 27 MAbs MAbs NNP cord-346321-drhiqch0 6 28 did do VBD cord-346321-drhiqch0 6 29 not not RB cord-346321-drhiqch0 6 30 . . . cord-346321-drhiqch0 7 1 These these DT cord-346321-drhiqch0 7 2 IgG igg NN cord-346321-drhiqch0 7 3 2a 2a CD cord-346321-drhiqch0 7 4 MAbs MAbs NNP cord-346321-drhiqch0 7 5 enhanced enhance VBD cord-346321-drhiqch0 7 6 the the DT cord-346321-drhiqch0 7 7 infection infection NN cord-346321-drhiqch0 7 8 even even RB cord-346321-drhiqch0 7 9 when when WRB cord-346321-drhiqch0 7 10 macrophages macrophage NNS cord-346321-drhiqch0 7 11 pretreated pretreate VBN cord-346321-drhiqch0 7 12 with with IN cord-346321-drhiqch0 7 13 the the DT cord-346321-drhiqch0 7 14 MAb MAb NNS cord-346321-drhiqch0 7 15 were be VBD cord-346321-drhiqch0 7 16 washed wash VBN cord-346321-drhiqch0 7 17 and and CC cord-346321-drhiqch0 7 18 then then RB cord-346321-drhiqch0 7 19 inoculated inoculate VBD cord-346321-drhiqch0 7 20 with with IN cord-346321-drhiqch0 7 21 the the DT cord-346321-drhiqch0 7 22 virus virus NN cord-346321-drhiqch0 7 23 . . . cord-346321-drhiqch0 8 1 Immunofluorescence immunofluorescence NN cord-346321-drhiqch0 8 2 flow flow NN cord-346321-drhiqch0 8 3 cytometric cytometric NN cord-346321-drhiqch0 8 4 analysis analysis NN cord-346321-drhiqch0 8 5 of of IN cord-346321-drhiqch0 8 6 the the DT cord-346321-drhiqch0 8 7 macrophages macrophage NNS cord-346321-drhiqch0 8 8 treated treat VBN cord-346321-drhiqch0 8 9 with with IN cord-346321-drhiqch0 8 10 each each DT cord-346321-drhiqch0 8 11 of of IN cord-346321-drhiqch0 8 12 the the DT cord-346321-drhiqch0 8 13 MAbs MAbs NNP cord-346321-drhiqch0 9 1 showed show VBD cord-346321-drhiqch0 9 2 that that IN cord-346321-drhiqch0 9 3 the the DT cord-346321-drhiqch0 9 4 IgG IgG NNP cord-346321-drhiqch0 9 5 2a 2a VBD cord-346321-drhiqch0 9 6 MAbs MAbs NNP cord-346321-drhiqch0 9 7 but but CC cord-346321-drhiqch0 9 8 not not RB cord-346321-drhiqch0 9 9 the the DT cord-346321-drhiqch0 9 10 IgG igg NN cord-346321-drhiqch0 9 11 1 1 CD cord-346321-drhiqch0 9 12 MAbs MAbs NNP cord-346321-drhiqch0 9 13 bound bind VBN cord-346321-drhiqch0 9 14 to to IN cord-346321-drhiqch0 9 15 feline feline JJ cord-346321-drhiqch0 9 16 alveolar alveolar NN cord-346321-drhiqch0 9 17 macrophages macrophage NNS cord-346321-drhiqch0 9 18 . . . cord-346321-drhiqch0 10 1 Treatment treatment NN cord-346321-drhiqch0 10 2 of of IN cord-346321-drhiqch0 10 3 the the DT cord-346321-drhiqch0 10 4 IgG IgG NNP cord-346321-drhiqch0 10 5 2a 2a CD cord-346321-drhiqch0 10 6 MAb MAb NNS cord-346321-drhiqch0 10 7 with with IN cord-346321-drhiqch0 10 8 protein protein NN cord-346321-drhiqch0 10 9 A A NNP cord-346321-drhiqch0 10 10 decreased decrease VBD cord-346321-drhiqch0 10 11 the the DT cord-346321-drhiqch0 10 12 binding binding NN cord-346321-drhiqch0 10 13 to to IN cord-346321-drhiqch0 10 14 the the DT cord-346321-drhiqch0 10 15 macrophages macrophage NNS cord-346321-drhiqch0 10 16 and and CC cord-346321-drhiqch0 10 17 , , , cord-346321-drhiqch0 10 18 in in IN cord-346321-drhiqch0 10 19 parallel parallel NN cord-346321-drhiqch0 10 20 , , , cord-346321-drhiqch0 10 21 diminished diminish VBD cord-346321-drhiqch0 10 22 the the DT cord-346321-drhiqch0 10 23 ADE ADE NNP cord-346321-drhiqch0 10 24 activity activity NN cord-346321-drhiqch0 10 25 . . . cord-346321-drhiqch0 11 1 Although although IN cord-346321-drhiqch0 11 2 no no DT cord-346321-drhiqch0 11 3 infection infection NN cord-346321-drhiqch0 11 4 was be VBD cord-346321-drhiqch0 11 5 observed observe VBN cord-346321-drhiqch0 11 6 by by IN cord-346321-drhiqch0 11 7 inoculation inoculation NN cord-346321-drhiqch0 11 8 of of IN cord-346321-drhiqch0 11 9 FIPV FIPV NNS cord-346321-drhiqch0 11 10 to to IN cord-346321-drhiqch0 11 11 human human JJ cord-346321-drhiqch0 11 12 monocyte monocyte NNP cord-346321-drhiqch0 11 13 cell cell NN cord-346321-drhiqch0 11 14 line line NN cord-346321-drhiqch0 11 15 U937 U937 NNP cord-346321-drhiqch0 11 16 cells cell NNS cord-346321-drhiqch0 11 17 , , , cord-346321-drhiqch0 11 18 FIPV FIPV NNP cord-346321-drhiqch0 11 19 complexed complexe VBN cord-346321-drhiqch0 11 20 with with IN cord-346321-drhiqch0 11 21 either either CC cord-346321-drhiqch0 11 22 the the DT cord-346321-drhiqch0 11 23 IgG IgG NNP cord-346321-drhiqch0 11 24 2a 2a CD cord-346321-drhiqch0 11 25 MAb MAb NNPS cord-346321-drhiqch0 11 26 or or CC cord-346321-drhiqch0 11 27 the the DT cord-346321-drhiqch0 11 28 IgG igg NN cord-346321-drhiqch0 11 29 1 1 CD cord-346321-drhiqch0 11 30 MAb MAb NNS cord-346321-drhiqch0 11 31 caused cause VBD cord-346321-drhiqch0 11 32 infection infection NN cord-346321-drhiqch0 11 33 in in IN cord-346321-drhiqch0 11 34 U937 U937 NNP cord-346321-drhiqch0 11 35 cells cell NNS cord-346321-drhiqch0 11 36 which which WDT cord-346321-drhiqch0 11 37 are be VBP cord-346321-drhiqch0 11 38 shown show VBN cord-346321-drhiqch0 11 39 to to TO cord-346321-drhiqch0 11 40 express express VB cord-346321-drhiqch0 11 41 Fc Fc NNP cord-346321-drhiqch0 11 42 gamma gamma NN cord-346321-drhiqch0 11 43 receptor receptor NN cord-346321-drhiqch0 11 44 ( ( -LRB- cord-346321-drhiqch0 11 45 Fc Fc NNP cord-346321-drhiqch0 11 46 γ γ NN cord-346321-drhiqch0 11 47 R r NN cord-346321-drhiqch0 11 48 ) ) -RRB- cord-346321-drhiqch0 12 1 I -PRON- PRP cord-346321-drhiqch0 12 2 and and CC cord-346321-drhiqch0 12 3 II II NNP cord-346321-drhiqch0 12 4 that that WDT cord-346321-drhiqch0 12 5 can can MD cord-346321-drhiqch0 12 6 bind bind VB cord-346321-drhiqch0 12 7 mouse mouse NN cord-346321-drhiqch0 12 8 IgG IgG NNP cord-346321-drhiqch0 12 9 2a 2a NNP cord-346321-drhiqch0 12 10 and and CC cord-346321-drhiqch0 12 11 IgG IgG NNP cord-346321-drhiqch0 12 12 1 1 CD cord-346321-drhiqch0 12 13 , , , cord-346321-drhiqch0 12 14 respectively respectively RB cord-346321-drhiqch0 12 15 . . . cord-346321-drhiqch0 13 1 These these DT cord-346321-drhiqch0 13 2 results result NNS cord-346321-drhiqch0 13 3 suggest suggest VBP cord-346321-drhiqch0 13 4 that that IN cord-346321-drhiqch0 13 5 the the DT cord-346321-drhiqch0 13 6 enhancing enhance VBG cord-346321-drhiqch0 13 7 activity activity NN cord-346321-drhiqch0 13 8 of of IN cord-346321-drhiqch0 13 9 MAb MAb NNS cord-346321-drhiqch0 13 10 is be VBZ cord-346321-drhiqch0 13 11 closely closely RB cord-346321-drhiqch0 13 12 correlated correlate VBN cord-346321-drhiqch0 13 13 with with IN cord-346321-drhiqch0 13 14 IgG igg NN cord-346321-drhiqch0 13 15 subclass subclass NN cord-346321-drhiqch0 13 16 and and CC cord-346321-drhiqch0 13 17 that that IN cord-346321-drhiqch0 13 18 the the DT cord-346321-drhiqch0 13 19 correlation correlation NN cord-346321-drhiqch0 13 20 is be VBZ cord-346321-drhiqch0 13 21 involved involve VBN cord-346321-drhiqch0 13 22 in in IN cord-346321-drhiqch0 13 23 binding binding NN cord-346321-drhiqch0 13 24 of of IN cord-346321-drhiqch0 13 25 MAb MAb NNS cord-346321-drhiqch0 13 26 to to IN cord-346321-drhiqch0 13 27 Fc Fc NNP cord-346321-drhiqch0 13 28 γ γ NN cord-346321-drhiqch0 13 29 R r NN cord-346321-drhiqch0 13 30 on on IN cord-346321-drhiqch0 13 31 feline feline JJ cord-346321-drhiqch0 13 32 macrophage macrophage NN cord-346321-drhiqch0 13 33 . . . cord-346321-drhiqch0 14 1 Feline feline JJ cord-346321-drhiqch0 14 2 infectious infectious JJ cord-346321-drhiqch0 14 3 peritonitis peritonitis NN cord-346321-drhiqch0 14 4 virus virus NN cord-346321-drhiqch0 14 5 ( ( -LRB- cord-346321-drhiqch0 14 6 FIPV FIPV NNP cord-346321-drhiqch0 14 7 ) ) -RRB- cord-346321-drhiqch0 14 8 is be VBZ cord-346321-drhiqch0 14 9 a a DT cord-346321-drhiqch0 14 10 member member NN cord-346321-drhiqch0 14 11 of of IN cord-346321-drhiqch0 14 12 the the DT cord-346321-drhiqch0 14 13 coronavirus coronavirus NN cord-346321-drhiqch0 14 14 family family NN cord-346321-drhiqch0 14 15 and and CC cord-346321-drhiqch0 14 16 causes cause VBZ cord-346321-drhiqch0 14 17 a a DT cord-346321-drhiqch0 14 18 chronic chronic JJ cord-346321-drhiqch0 14 19 progressive progressive JJ cord-346321-drhiqch0 14 20 disease disease NN cord-346321-drhiqch0 14 21 in in IN cord-346321-drhiqch0 14 22 its -PRON- PRP$ cord-346321-drhiqch0 14 23 natural natural JJ cord-346321-drhiqch0 14 24 host host NN cord-346321-drhiqch0 14 25 . . . cord-346321-drhiqch0 15 1 The the DT cord-346321-drhiqch0 15 2 natural natural JJ cord-346321-drhiqch0 15 3 route route NN cord-346321-drhiqch0 15 4 of of IN cord-346321-drhiqch0 15 5 FIPV FIPV NNP cord-346321-drhiqch0 15 6 infection infection NN cord-346321-drhiqch0 15 7 is be VBZ cord-346321-drhiqch0 15 8 unknown unknown JJ cord-346321-drhiqch0 15 9 although although IN cord-346321-drhiqch0 15 10 cats cat NNS cord-346321-drhiqch0 15 11 can can MD cord-346321-drhiqch0 15 12 be be VB cord-346321-drhiqch0 15 13 experimentally experimentally RB cord-346321-drhiqch0 15 14 infected infect VBN cord-346321-drhiqch0 15 15 by by IN cord-346321-drhiqch0 15 16 oral oral JJ cord-346321-drhiqch0 15 17 , , , cord-346321-drhiqch0 15 18 nasal nasal NN cord-346321-drhiqch0 15 19 , , , cord-346321-drhiqch0 15 20 and and CC cord-346321-drhiqch0 15 21 parenteral parenteral JJ cord-346321-drhiqch0 15 22 administration administration NN cord-346321-drhiqch0 15 23 of of IN cord-346321-drhiqch0 15 24 FIPV FIPV NNP cord-346321-drhiqch0 15 25 . . . cord-346321-drhiqch0 16 1 Following follow VBG cord-346321-drhiqch0 16 2 infection infection NN cord-346321-drhiqch0 16 3 by by IN cord-346321-drhiqch0 16 4 these these DT cord-346321-drhiqch0 16 5 routes route NNS cord-346321-drhiqch0 16 6 , , , cord-346321-drhiqch0 16 7 FIPV FIPV NNP cord-346321-drhiqch0 16 8 first first RB cord-346321-drhiqch0 16 9 multiplies multiply VBZ cord-346321-drhiqch0 16 10 in in IN cord-346321-drhiqch0 16 11 the the DT cord-346321-drhiqch0 16 12 epithelial epithelial JJ cord-346321-drhiqch0 16 13 cells cell NNS cord-346321-drhiqch0 16 14 of of IN cord-346321-drhiqch0 16 15 the the DT cord-346321-drhiqch0 16 16 upper upper JJ cord-346321-drhiqch0 16 17 respiratory respiratory JJ cord-346321-drhiqch0 16 18 tract tract NN cord-346321-drhiqch0 16 19 and and CC cord-346321-drhiqch0 16 20 intestine intestine NN cord-346321-drhiqch0 16 21 [ [ -LRB- cord-346321-drhiqch0 16 22 30 30 CD cord-346321-drhiqch0 16 23 ] ] -RRB- cord-346321-drhiqch0 16 24 . . . cord-346321-drhiqch0 17 1 Clinically clinically RB cord-346321-drhiqch0 17 2 apparent apparent JJ cord-346321-drhiqch0 17 3 FIP fip NN cord-346321-drhiqch0 17 4 occurs occur VBZ cord-346321-drhiqch0 17 5 after after IN cord-346321-drhiqch0 17 6 the the DT cord-346321-drhiqch0 17 7 viruses virus NNS cord-346321-drhiqch0 17 8 in in IN cord-346321-drhiqch0 17 9 infected infected JJ cord-346321-drhiqch0 17 10 274 274 CD cord-346321-drhiqch0 17 11 T. t. NN cord-346321-drhiqch0 17 12 Hohdatsu Hohdatsu NNP cord-346321-drhiqch0 17 13 et et NNP cord-346321-drhiqch0 17 14 al al NNP cord-346321-drhiqch0 17 15 . . . cord-346321-drhiqch0 18 1 macrophages macrophage NNS cord-346321-drhiqch0 18 2 and and CC cord-346321-drhiqch0 18 3 monocytes monocyte VBZ cord-346321-drhiqch0 18 4 cross cross VBP cord-346321-drhiqch0 18 5 the the DT cord-346321-drhiqch0 18 6 mucosal mucosal JJ cord-346321-drhiqch0 18 7 barrier barrier NN cord-346321-drhiqch0 18 8 and and CC cord-346321-drhiqch0 18 9 spread spread VBD cord-346321-drhiqch0 18 10 throughout throughout IN cord-346321-drhiqch0 18 11 the the DT cord-346321-drhiqch0 18 12 body body NN cord-346321-drhiqch0 18 13 of of IN cord-346321-drhiqch0 18 14 the the DT cord-346321-drhiqch0 18 15 cat cat NN cord-346321-drhiqch0 18 16 . . . cord-346321-drhiqch0 19 1 Generally generally RB cord-346321-drhiqch0 19 2 , , , cord-346321-drhiqch0 19 3 macrophages macrophage NNS cord-346321-drhiqch0 19 4 play play VBP cord-346321-drhiqch0 19 5 an an DT cord-346321-drhiqch0 19 6 important important JJ cord-346321-drhiqch0 19 7 role role NN cord-346321-drhiqch0 19 8 in in IN cord-346321-drhiqch0 19 9 non non JJ cord-346321-drhiqch0 19 10 - - JJ cord-346321-drhiqch0 19 11 specific specific JJ cord-346321-drhiqch0 19 12 defense defense NN cord-346321-drhiqch0 19 13 against against IN cord-346321-drhiqch0 19 14 viral viral JJ cord-346321-drhiqch0 19 15 infection infection NN cord-346321-drhiqch0 19 16 . . . cord-346321-drhiqch0 20 1 However however RB cord-346321-drhiqch0 20 2 , , , cord-346321-drhiqch0 20 3 it -PRON- PRP cord-346321-drhiqch0 20 4 is be VBZ cord-346321-drhiqch0 20 5 also also RB cord-346321-drhiqch0 20 6 known know VBN cord-346321-drhiqch0 20 7 that that IN cord-346321-drhiqch0 20 8 viruses virus NNS cord-346321-drhiqch0 20 9 bound bind VBN cord-346321-drhiqch0 20 10 to to IN cord-346321-drhiqch0 20 11 antibodies antibody NNS cord-346321-drhiqch0 20 12 invade invade VBP cord-346321-drhiqch0 20 13 macrophages macrophage NNS cord-346321-drhiqch0 20 14 via via IN cord-346321-drhiqch0 20 15 Fc Fc NNP cord-346321-drhiqch0 20 16 region region NN cord-346321-drhiqch0 20 17 of of IN cord-346321-drhiqch0 20 18 the the DT cord-346321-drhiqch0 20 19 bound bind VBN cord-346321-drhiqch0 20 20 antibody antibody NN cord-346321-drhiqch0 20 21 and and CC cord-346321-drhiqch0 20 22 the the DT cord-346321-drhiqch0 20 23 macrophage macrophage NN cord-346321-drhiqch0 20 24 's 's POS cord-346321-drhiqch0 20 25 Fc Fc NNP cord-346321-drhiqch0 20 26 gamma gamma NN cord-346321-drhiqch0 20 27 receptor receptor NN cord-346321-drhiqch0 20 28 ( ( -LRB- cord-346321-drhiqch0 20 29 Fc Fc NNP cord-346321-drhiqch0 20 30 7 7 CD cord-346321-drhiqch0 20 31 R R NNP cord-346321-drhiqch0 20 32 ) ) -RRB- cord-346321-drhiqch0 20 33 and and CC cord-346321-drhiqch0 20 34 eventually eventually RB cord-346321-drhiqch0 20 35 lead lead VBP cord-346321-drhiqch0 20 36 to to IN cord-346321-drhiqch0 20 37 enhancement enhancement NN cord-346321-drhiqch0 20 38 of of IN cord-346321-drhiqch0 20 39 infection infection NN cord-346321-drhiqch0 20 40 [ [ -LRB- cord-346321-drhiqch0 20 41 4 4 CD cord-346321-drhiqch0 20 42 , , , cord-346321-drhiqch0 20 43 7 7 CD cord-346321-drhiqch0 20 44 - - SYM cord-346321-drhiqch0 20 45 10 10 CD cord-346321-drhiqch0 20 46 , , , cord-346321-drhiqch0 20 47 14 14 CD cord-346321-drhiqch0 20 48 , , , cord-346321-drhiqch0 20 49 26 26 CD cord-346321-drhiqch0 20 50 , , , cord-346321-drhiqch0 20 51 27 27 CD cord-346321-drhiqch0 20 52 , , , cord-346321-drhiqch0 20 53 31 31 CD cord-346321-drhiqch0 20 54 ] ] -RRB- cord-346321-drhiqch0 20 55 . . . cord-346321-drhiqch0 21 1 Its -PRON- PRP$ cord-346321-drhiqch0 21 2 most most RBS cord-346321-drhiqch0 21 3 typical typical JJ cord-346321-drhiqch0 21 4 example example NN cord-346321-drhiqch0 21 5 is be VBZ cord-346321-drhiqch0 21 6 a a DT cord-346321-drhiqch0 21 7 disease disease NN cord-346321-drhiqch0 21 8 called call VBN cord-346321-drhiqch0 21 9 dengue dengue NN cord-346321-drhiqch0 21 10 hemorrhagic hemorrhagic JJ cord-346321-drhiqch0 21 11 fever fever NN cord-346321-drhiqch0 21 12 / / SYM cord-346321-drhiqch0 21 13 dengue dengue NN cord-346321-drhiqch0 21 14 shock shock NN cord-346321-drhiqch0 21 15 syndrome syndrome NN cord-346321-drhiqch0 21 16 . . . cord-346321-drhiqch0 22 1 The the DT cord-346321-drhiqch0 22 2 antibody antibody NN cord-346321-drhiqch0 22 3 for for IN cord-346321-drhiqch0 22 4 FIPV FIPV NNP cord-346321-drhiqch0 22 5 is be VBZ cord-346321-drhiqch0 22 6 also also RB cord-346321-drhiqch0 22 7 known know VBN cord-346321-drhiqch0 22 8 to to TO cord-346321-drhiqch0 22 9 enhance enhance VB cord-346321-drhiqch0 22 10 the the DT cord-346321-drhiqch0 22 11 FIPV FIPV NNS cord-346321-drhiqch0 22 12 infection infection NN cord-346321-drhiqch0 22 13 and and CC cord-346321-drhiqch0 22 14 accelerate accelerate VB cord-346321-drhiqch0 22 15 the the DT cord-346321-drhiqch0 22 16 disease disease NN cord-346321-drhiqch0 22 17 onset onset NN cord-346321-drhiqch0 22 18 in in IN cord-346321-drhiqch0 22 19 cats cat NNS cord-346321-drhiqch0 22 20 [ [ -LRB- cord-346321-drhiqch0 22 21 22 22 CD cord-346321-drhiqch0 22 22 , , , cord-346321-drhiqch0 22 23 23 23 CD cord-346321-drhiqch0 22 24 , , , cord-346321-drhiqch0 22 25 34 34 CD cord-346321-drhiqch0 22 26 ] ] -RRB- cord-346321-drhiqch0 22 27 . . . cord-346321-drhiqch0 23 1 Following follow VBG cord-346321-drhiqch0 23 2 experimental experimental JJ cord-346321-drhiqch0 23 3 FIPV FIPV NNS cord-346321-drhiqch0 23 4 infection infection NN cord-346321-drhiqch0 23 5 , , , cord-346321-drhiqch0 23 6 cats cat NNS cord-346321-drhiqch0 23 7 with with IN cord-346321-drhiqch0 23 8 naturally naturally RB cord-346321-drhiqch0 23 9 occurring occur VBG cord-346321-drhiqch0 23 10 FIPV FIPV NNS cord-346321-drhiqch0 23 11 - - HYPH cord-346321-drhiqch0 23 12 neutralizing neutralize VBG cord-346321-drhiqch0 23 13 antibody antibody NN cord-346321-drhiqch0 23 14 frequently frequently RB cord-346321-drhiqch0 23 15 develop develop VB cord-346321-drhiqch0 23 16 FIP FIP NNP cord-346321-drhiqch0 23 17 more more RBR cord-346321-drhiqch0 23 18 rapidly rapidly RB cord-346321-drhiqch0 23 19 and and CC cord-346321-drhiqch0 23 20 with with IN cord-346321-drhiqch0 23 21 more more RBR cord-346321-drhiqch0 23 22 severe severe JJ cord-346321-drhiqch0 23 23 clinical clinical JJ cord-346321-drhiqch0 23 24 signs sign NNS cord-346321-drhiqch0 23 25 than than IN cord-346321-drhiqch0 23 26 do do VB cord-346321-drhiqch0 23 27 seronegative seronegative JJ cord-346321-drhiqch0 23 28 cats cat NNS cord-346321-drhiqch0 23 29 . . . cord-346321-drhiqch0 24 1 When when WRB cord-346321-drhiqch0 24 2 cats cat NNS cord-346321-drhiqch0 24 3 passively passively RB cord-346321-drhiqch0 24 4 immunized immunize VBN cord-346321-drhiqch0 24 5 with with IN cord-346321-drhiqch0 24 6 anti anti JJ cord-346321-drhiqch0 24 7 - - JJ cord-346321-drhiqch0 24 8 FIPV FIPV NNP cord-346321-drhiqch0 24 9 antibodies antibody NNS cord-346321-drhiqch0 24 10 were be VBD cord-346321-drhiqch0 24 11 infected infect VBN cord-346321-drhiqch0 24 12 with with IN cord-346321-drhiqch0 24 13 virulent virulent JJ cord-346321-drhiqch0 24 14 FIPV FIPV NNS cord-346321-drhiqch0 24 15 , , , cord-346321-drhiqch0 24 16 severe severe JJ cord-346321-drhiqch0 24 17 symptoms symptom NNS cord-346321-drhiqch0 24 18 were be VBD cord-346321-drhiqch0 24 19 observed observe VBN cord-346321-drhiqch0 24 20 and and CC cord-346321-drhiqch0 24 21 some some DT cord-346321-drhiqch0 24 22 of of IN cord-346321-drhiqch0 24 23 them -PRON- PRP cord-346321-drhiqch0 24 24 died die VBD cord-346321-drhiqch0 24 25 soon soon RB cord-346321-drhiqch0 24 26 after after IN cord-346321-drhiqch0 24 27 the the DT cord-346321-drhiqch0 24 28 infection infection NN cord-346321-drhiqch0 24 29 [ [ -LRB- cord-346321-drhiqch0 24 30 22 22 CD cord-346321-drhiqch0 24 31 , , , cord-346321-drhiqch0 24 32 34 34 CD cord-346321-drhiqch0 24 33 ] ] -RRB- cord-346321-drhiqch0 24 34 . . . cord-346321-drhiqch0 25 1 The the DT cord-346321-drhiqch0 25 2 enhancing enhance VBG cord-346321-drhiqch0 25 3 effect effect NN cord-346321-drhiqch0 25 4 of of IN cord-346321-drhiqch0 25 5 the the DT cord-346321-drhiqch0 25 6 antibody antibody NN cord-346321-drhiqch0 25 7 of of IN cord-346321-drhiqch0 25 8 FIPV FIPV NNP cord-346321-drhiqch0 25 9 infection infection NN cord-346321-drhiqch0 25 10 impedes impede VBZ cord-346321-drhiqch0 25 11 prophylaxis prophylaxis NN cord-346321-drhiqch0 25 12 of of IN cord-346321-drhiqch0 25 13 FIP FIP NNP cord-346321-drhiqch0 25 14 by by IN cord-346321-drhiqch0 25 15 vaccination vaccination NN cord-346321-drhiqch0 25 16 [ [ -LRB- cord-346321-drhiqch0 25 17 2 2 CD cord-346321-drhiqch0 25 18 , , , cord-346321-drhiqch0 25 19 21 21 CD cord-346321-drhiqch0 25 20 , , , cord-346321-drhiqch0 25 21 23 23 CD cord-346321-drhiqch0 25 22 - - SYM cord-346321-drhiqch0 25 23 25 25 CD cord-346321-drhiqch0 25 24 , , , cord-346321-drhiqch0 25 25 29 29 CD cord-346321-drhiqch0 25 26 , , , cord-346321-drhiqch0 25 27 35 35 CD cord-346321-drhiqch0 25 28 ] ] -RRB- cord-346321-drhiqch0 25 29 . . . cord-346321-drhiqch0 26 1 We -PRON- PRP cord-346321-drhiqch0 26 2 previously previously RB cord-346321-drhiqch0 26 3 reported report VBD cord-346321-drhiqch0 26 4 that that IN cord-346321-drhiqch0 26 5 in in IN cord-346321-drhiqch0 26 6 vitro vitro FW cord-346321-drhiqch0 26 7 FIPV FIPV NNP cord-346321-drhiqch0 26 8 infection infection NN cord-346321-drhiqch0 26 9 of of IN cord-346321-drhiqch0 26 10 feline feline JJ cord-346321-drhiqch0 26 11 alveolar alveolar NN cord-346321-drhiqch0 26 12 macrophages macrophage NNS cord-346321-drhiqch0 26 13 is be VBZ cord-346321-drhiqch0 26 14 enhanced enhance VBN cord-346321-drhiqch0 26 15 by by IN cord-346321-drhiqch0 26 16 murine murine JJ cord-346321-drhiqch0 26 17 monoclonal monoclonal JJ cord-346321-drhiqch0 26 18 antibodies antibody NNS cord-346321-drhiqch0 26 19 ( ( -LRB- cord-346321-drhiqch0 26 20 MAbs MAbs NNP cord-346321-drhiqch0 26 21 ) ) -RRB- cord-346321-drhiqch0 26 22 to to IN cord-346321-drhiqch0 26 23 the the DT cord-346321-drhiqch0 26 24 peplomer peplomer JJ cord-346321-drhiqch0 26 25 spike spike NN cord-346321-drhiqch0 26 26 ( ( -LRB- cord-346321-drhiqch0 26 27 S s NN cord-346321-drhiqch0 26 28 ) ) -RRB- cord-346321-drhiqch0 26 29 protein protein NN cord-346321-drhiqch0 26 30 or or CC cord-346321-drhiqch0 26 31 the the DT cord-346321-drhiqch0 26 32 transmembrane transmembrane NN cord-346321-drhiqch0 26 33 ( ( -LRB- cord-346321-drhiqch0 26 34 M M NNP cord-346321-drhiqch0 26 35 ) ) -RRB- cord-346321-drhiqch0 26 36 protein protein NN cord-346321-drhiqch0 26 37 of of IN cord-346321-drhiqch0 26 38 FIPV FIPV NNPS cord-346321-drhiqch0 26 39 [ [ -LRB- cord-346321-drhiqch0 26 40 12 12 CD cord-346321-drhiqch0 26 41 , , , cord-346321-drhiqch0 26 42 13 13 CD cord-346321-drhiqch0 26 43 ] ] -RRB- cord-346321-drhiqch0 26 44 . . . cord-346321-drhiqch0 27 1 This this DT cord-346321-drhiqch0 27 2 antibody antibody NN cord-346321-drhiqch0 27 3 - - HYPH cord-346321-drhiqch0 27 4 dependent dependent JJ cord-346321-drhiqch0 27 5 enhancement enhancement NN cord-346321-drhiqch0 27 6 ( ( -LRB- cord-346321-drhiqch0 27 7 ADE ADE NNP cord-346321-drhiqch0 27 8 ) ) -RRB- cord-346321-drhiqch0 27 9 was be VBD cord-346321-drhiqch0 27 10 completely completely RB cord-346321-drhiqch0 27 11 eliminated eliminate VBN cord-346321-drhiqch0 27 12 or or CC cord-346321-drhiqch0 27 13 reduced reduce VBN cord-346321-drhiqch0 27 14 by by IN cord-346321-drhiqch0 27 15 pretreatment pretreatment NN cord-346321-drhiqch0 27 16 of of IN cord-346321-drhiqch0 27 17 the the DT cord-346321-drhiqch0 27 18 MAbs MAbs NNP cord-346321-drhiqch0 27 19 with with IN cord-346321-drhiqch0 27 20 Protein Protein NNP cord-346321-drhiqch0 27 21 A A NNP cord-346321-drhiqch0 27 22 or or CC cord-346321-drhiqch0 27 23 when when WRB cord-346321-drhiqch0 27 24 F(ab')2 f(ab')2 XX cord-346321-drhiqch0 27 25 fragments fragment NNS cord-346321-drhiqch0 27 26 of of IN cord-346321-drhiqch0 27 27 the the DT cord-346321-drhiqch0 27 28 MAbs MAbs NNP cord-346321-drhiqch0 27 29 were be VBD cord-346321-drhiqch0 27 30 used use VBN cord-346321-drhiqch0 27 31 . . . cord-346321-drhiqch0 28 1 Olsen Olsen NNP cord-346321-drhiqch0 28 2 et et NNP cord-346321-drhiqch0 28 3 al al NNP cord-346321-drhiqch0 28 4 . . NNP cord-346321-drhiqch0 28 5 have have VBP cord-346321-drhiqch0 28 6 supported support VBN cord-346321-drhiqch0 28 7 our -PRON- PRP$ cord-346321-drhiqch0 28 8 findings finding NNS cord-346321-drhiqch0 28 9 by by IN cord-346321-drhiqch0 28 10 showing show VBG cord-346321-drhiqch0 28 11 enhancement enhancement NN cord-346321-drhiqch0 28 12 of of IN cord-346321-drhiqch0 28 13 FIPV FIPV NNS cord-346321-drhiqch0 28 14 infection infection NN cord-346321-drhiqch0 28 15 in in IN cord-346321-drhiqch0 28 16 primary primary JJ cord-346321-drhiqch0 28 17 feline feline JJ cord-346321-drhiqch0 28 18 peritoneal peritoneal NN cord-346321-drhiqch0 28 19 macrophages macrophage NNS cord-346321-drhiqch0 28 20 by by IN cord-346321-drhiqch0 28 21 mouse mouse NNP cord-346321-drhiqch0 28 22 MAbs MAbs NNP cord-346321-drhiqch0 28 23 to to IN cord-346321-drhiqch0 28 24 the the DT cord-346321-drhiqch0 28 25 viral viral JJ cord-346321-drhiqch0 28 26 S s NN cord-346321-drhiqch0 28 27 protein protein NN cord-346321-drhiqch0 28 28 [ [ -LRB- cord-346321-drhiqch0 28 29 20 20 CD cord-346321-drhiqch0 28 30 ] ] -RRB- cord-346321-drhiqch0 28 31 . . . cord-346321-drhiqch0 29 1 In in IN cord-346321-drhiqch0 29 2 many many JJ cord-346321-drhiqch0 29 3 instances instance NNS cord-346321-drhiqch0 29 4 virus virus NN cord-346321-drhiqch0 29 5 - - HYPH cord-346321-drhiqch0 29 6 neutralizing neutralize VBG cord-346321-drhiqch0 29 7 MAbs MAbs NNP cord-346321-drhiqch0 29 8 were be VBD cord-346321-drhiqch0 29 9 shown show VBN cord-346321-drhiqch0 29 10 to to TO cord-346321-drhiqch0 29 11 have have VB cord-346321-drhiqch0 29 12 strong strong JJ cord-346321-drhiqch0 29 13 ADE ade NN cord-346321-drhiqch0 29 14 activity activity NN cord-346321-drhiqch0 29 15 , , , cord-346321-drhiqch0 29 16 and and CC cord-346321-drhiqch0 29 17 it -PRON- PRP cord-346321-drhiqch0 29 18 was be VBD cord-346321-drhiqch0 29 19 suggested suggest VBN cord-346321-drhiqch0 29 20 that that IN cord-346321-drhiqch0 29 21 there there EX cord-346321-drhiqch0 29 22 was be VBD cord-346321-drhiqch0 29 23 some some DT cord-346321-drhiqch0 29 24 relationship relationship NN cord-346321-drhiqch0 29 25 between between IN cord-346321-drhiqch0 29 26 neutralizing neutralize VBG cord-346321-drhiqch0 29 27 activity activity NN cord-346321-drhiqch0 29 28 and and CC cord-346321-drhiqch0 29 29 ADE ade NN cord-346321-drhiqch0 29 30 activity activity NN cord-346321-drhiqch0 29 31 . . . cord-346321-drhiqch0 30 1 On on IN cord-346321-drhiqch0 30 2 the the DT cord-346321-drhiqch0 30 3 other other JJ cord-346321-drhiqch0 30 4 hand hand NN cord-346321-drhiqch0 30 5 , , , cord-346321-drhiqch0 30 6 Corapi Corapi NNP cord-346321-drhiqch0 30 7 et et NNP cord-346321-drhiqch0 30 8 al al NNP cord-346321-drhiqch0 30 9 . . NNP cord-346321-drhiqch0 30 10 recognized recognize VBD cord-346321-drhiqch0 30 11 a a DT cord-346321-drhiqch0 30 12 difference difference NN cord-346321-drhiqch0 30 13 in in IN cord-346321-drhiqch0 30 14 immunoglobulin immunoglobulin NN cord-346321-drhiqch0 30 15 subclasses subclass NNS cord-346321-drhiqch0 30 16 between between IN cord-346321-drhiqch0 30 17 ADE ade NN cord-346321-drhiqch0 30 18 - - HYPH cord-346321-drhiqch0 30 19 inducing induce VBG cord-346321-drhiqch0 30 20 FIPV FIPV NNP cord-346321-drhiqch0 30 21 - - HYPH cord-346321-drhiqch0 30 22 neutralizing neutralize VBG cord-346321-drhiqch0 30 23 MAb MAb NNS cord-346321-drhiqch0 30 24 and and CC cord-346321-drhiqch0 30 25 ADE ade NN cord-346321-drhiqch0 30 26 - - HYPH cord-346321-drhiqch0 30 27 non non JJ cord-346321-drhiqch0 30 28 inducing induce VBG cord-346321-drhiqch0 30 29 FIPV FIPV NNS cord-346321-drhiqch0 30 30 - - HYPH cord-346321-drhiqch0 30 31 neutralizing neutralize VBG cord-346321-drhiqch0 30 32 MAb MAb NNS cord-346321-drhiqch0 30 33 , , , cord-346321-drhiqch0 30 34 and and CC cord-346321-drhiqch0 30 35 they -PRON- PRP cord-346321-drhiqch0 30 36 showed show VBD cord-346321-drhiqch0 30 37 that that IN cord-346321-drhiqch0 30 38 the the DT cord-346321-drhiqch0 30 39 majority majority NN cord-346321-drhiqch0 30 40 of of IN cord-346321-drhiqch0 30 41 the the DT cord-346321-drhiqch0 30 42 ADE ADE NNP cord-346321-drhiqch0 30 43 - - HYPH cord-346321-drhiqch0 30 44 inducing induce VBG cord-346321-drhiqch0 30 45 MAbs MAbs NNP cord-346321-drhiqch0 30 46 belong belong VBP cord-346321-drhiqch0 30 47 to to IN cord-346321-drhiqch0 30 48 the the DT cord-346321-drhiqch0 30 49 IgG IgG NNP cord-346321-drhiqch0 30 50 2a 2a CD cord-346321-drhiqch0 30 51 subclass subclass NNP cord-346321-drhiqch0 30 52 [ [ -LRB- cord-346321-drhiqch0 30 53 5 5 CD cord-346321-drhiqch0 30 54 ] ] -RRB- cord-346321-drhiqch0 30 55 . . . cord-346321-drhiqch0 31 1 These these DT cord-346321-drhiqch0 31 2 results result NNS cord-346321-drhiqch0 31 3 were be VBD cord-346321-drhiqch0 31 4 obtained obtain VBN cord-346321-drhiqch0 31 5 by by IN cord-346321-drhiqch0 31 6 the the DT cord-346321-drhiqch0 31 7 experiments experiment NNS cord-346321-drhiqch0 31 8 in in IN cord-346321-drhiqch0 31 9 which which WDT cord-346321-drhiqch0 31 10 mouse mouse NN cord-346321-drhiqch0 31 11 MAbs MAbs NNP cord-346321-drhiqch0 31 12 and and CC cord-346321-drhiqch0 31 13 feline feline JJ cord-346321-drhiqch0 31 14 macrophages macrophage NNS cord-346321-drhiqch0 31 15 , , , cord-346321-drhiqch0 31 16 i.e. i.e. FW cord-346321-drhiqch0 31 17 , , , cord-346321-drhiqch0 31 18 xenogeneic xenogeneic NNP cord-346321-drhiqch0 31 19 combination combination NN cord-346321-drhiqch0 31 20 of of IN cord-346321-drhiqch0 31 21 MAbs MAbs NNP cord-346321-drhiqch0 31 22 and and CC cord-346321-drhiqch0 31 23 macrophages macrophage NNS cord-346321-drhiqch0 31 24 , , , cord-346321-drhiqch0 31 25 were be VBD cord-346321-drhiqch0 31 26 used use VBN cord-346321-drhiqch0 31 27 . . . cord-346321-drhiqch0 32 1 In in IN cord-346321-drhiqch0 32 2 contrast contrast NN cord-346321-drhiqch0 32 3 , , , cord-346321-drhiqch0 32 4 it -PRON- PRP cord-346321-drhiqch0 32 5 has have VBZ cord-346321-drhiqch0 32 6 been be VBN cord-346321-drhiqch0 32 7 reported report VBN cord-346321-drhiqch0 32 8 that that IN cord-346321-drhiqch0 32 9 mouse mouse NN cord-346321-drhiqch0 32 10 MAbs MAbs NNP cord-346321-drhiqch0 32 11 irrespective irrespective RB cord-346321-drhiqch0 32 12 of of IN cord-346321-drhiqch0 32 13 whether whether IN cord-346321-drhiqch0 32 14 the the DT cord-346321-drhiqch0 32 15 subclass subclass NN cord-346321-drhiqch0 32 16 is be VBZ cord-346321-drhiqch0 32 17 IgG IgG NNP cord-346321-drhiqch0 32 18 1 1 CD cord-346321-drhiqch0 32 19 , , , cord-346321-drhiqch0 32 20 IgG IgG NNP cord-346321-drhiqch0 32 21 2a 2a CD cord-346321-drhiqch0 32 22 or or CC cord-346321-drhiqch0 32 23 IgG IgG NNP cord-346321-drhiqch0 32 24 2b 2b NNP cord-346321-drhiqch0 32 25 enhanced enhance VBD cord-346321-drhiqch0 32 26 infection infection NN cord-346321-drhiqch0 32 27 of of IN cord-346321-drhiqch0 32 28 mouse mouse NN cord-346321-drhiqch0 32 29 ( ( -LRB- cord-346321-drhiqch0 32 30 homologous homologous JJ cord-346321-drhiqch0 32 31 ) ) -RRB- cord-346321-drhiqch0 32 32 macrophages macrophage NNS cord-346321-drhiqch0 32 33 of of IN cord-346321-drhiqch0 32 34 dengue dengue NN cord-346321-drhiqch0 32 35 virus virus NN cord-346321-drhiqch0 32 36 [ [ -LRB- cord-346321-drhiqch0 32 37 10 10 CD cord-346321-drhiqch0 32 38 , , , cord-346321-drhiqch0 32 39 17 17 CD cord-346321-drhiqch0 32 40 ] ] -RRB- cord-346321-drhiqch0 32 41 , , , cord-346321-drhiqch0 32 42 influenza influenza NN cord-346321-drhiqch0 32 43 A a DT cord-346321-drhiqch0 32 44 virus virus NN cord-346321-drhiqch0 32 45 [ [ -LRB- cord-346321-drhiqch0 32 46 18 18 CD cord-346321-drhiqch0 32 47 " " '' cord-346321-drhiqch0 32 48 ] ] -RRB- cord-346321-drhiqch0 32 49 and and CC cord-346321-drhiqch0 32 50 West West NNP cord-346321-drhiqch0 32 51 Nile Nile NNP cord-346321-drhiqch0 32 52 virus virus NN cord-346321-drhiqch0 32 53 [ [ -LRB- cord-346321-drhiqch0 32 54 3 3 CD cord-346321-drhiqch0 32 55 ] ] -RRB- cord-346321-drhiqch0 32 56 . . . cord-346321-drhiqch0 33 1 Since since IN cord-346321-drhiqch0 33 2 ADE ADE NNP cord-346321-drhiqch0 33 3 of of IN cord-346321-drhiqch0 33 4 the the DT cord-346321-drhiqch0 33 5 disease disease NN cord-346321-drhiqch0 33 6 caused cause VBN cord-346321-drhiqch0 33 7 by by IN cord-346321-drhiqch0 33 8 FIPV FIPV NNP cord-346321-drhiqch0 33 9 has have VBZ cord-346321-drhiqch0 33 10 been be VBN cord-346321-drhiqch0 33 11 clearly clearly RB cord-346321-drhiqch0 33 12 demonstrated demonstrate VBN cord-346321-drhiqch0 33 13 after after IN cord-346321-drhiqch0 33 14 vaccination vaccination NN cord-346321-drhiqch0 33 15 of of IN cord-346321-drhiqch0 33 16 cats cat NNS cord-346321-drhiqch0 33 17 with with IN cord-346321-drhiqch0 33 18 a a DT cord-346321-drhiqch0 33 19 variety variety NN cord-346321-drhiqch0 33 20 of of IN cord-346321-drhiqch0 33 21 candidate candidate NN cord-346321-drhiqch0 33 22 vaccines vaccine NNS cord-346321-drhiqch0 33 23 , , , cord-346321-drhiqch0 33 24 a a DT cord-346321-drhiqch0 33 25 more more RBR cord-346321-drhiqch0 33 26 specific specific JJ cord-346321-drhiqch0 33 27 understanding understanding NN cord-346321-drhiqch0 33 28 of of IN cord-346321-drhiqch0 33 29 ADE ADE NNP cord-346321-drhiqch0 33 30 of of IN cord-346321-drhiqch0 33 31 FIPV FIPV NNS cord-346321-drhiqch0 33 32 infection infection NN cord-346321-drhiqch0 33 33 is be VBZ cord-346321-drhiqch0 33 34 needed need VBN cord-346321-drhiqch0 33 35 [ [ -LRB- cord-346321-drhiqch0 33 36 2 2 CD cord-346321-drhiqch0 33 37 , , , cord-346321-drhiqch0 33 38 21 21 CD cord-346321-drhiqch0 33 39 , , , cord-346321-drhiqch0 33 40 23 23 CD cord-346321-drhiqch0 33 41 - - SYM cord-346321-drhiqch0 33 42 25 25 CD cord-346321-drhiqch0 33 43 , , , cord-346321-drhiqch0 33 44 30 30 CD cord-346321-drhiqch0 33 45 , , , cord-346321-drhiqch0 33 46 35 35 CD cord-346321-drhiqch0 33 47 ] ] -RRB- cord-346321-drhiqch0 33 48 . . . cord-346321-drhiqch0 34 1 It -PRON- PRP cord-346321-drhiqch0 34 2 is be VBZ cord-346321-drhiqch0 34 3 especially especially RB cord-346321-drhiqch0 34 4 important important JJ cord-346321-drhiqch0 34 5 for for IN cord-346321-drhiqch0 34 6 development development NN cord-346321-drhiqch0 34 7 of of IN cord-346321-drhiqch0 34 8 vaccines vaccine NNS cord-346321-drhiqch0 34 9 to to TO cord-346321-drhiqch0 34 10 understand understand VB cord-346321-drhiqch0 34 11 the the DT cord-346321-drhiqch0 34 12 relationship relationship NN cord-346321-drhiqch0 34 13 between between IN cord-346321-drhiqch0 34 14 FIPV FIPV NNS cord-346321-drhiqch0 34 15 neutralizing neutralize VBG cord-346321-drhiqch0 34 16 activity activity NN cord-346321-drhiqch0 34 17 and and CC cord-346321-drhiqch0 34 18 ADE ADE NNP cord-346321-drhiqch0 34 19 activity activity NN cord-346321-drhiqch0 34 20 of of IN cord-346321-drhiqch0 34 21 anti anti NNP cord-346321-drhiqch0 34 22 FIPV FIPV NNP cord-346321-drhiqch0 34 23 MAbs MAbs NNP cord-346321-drhiqch0 34 24 . . . cord-346321-drhiqch0 35 1 In in IN cord-346321-drhiqch0 35 2 this this DT cord-346321-drhiqch0 35 3 study study NN cord-346321-drhiqch0 35 4 , , , cord-346321-drhiqch0 35 5 we -PRON- PRP cord-346321-drhiqch0 35 6 determined determine VBD cord-346321-drhiqch0 35 7 the the DT cord-346321-drhiqch0 35 8 relationship relationship NN cord-346321-drhiqch0 35 9 between between IN cord-346321-drhiqch0 35 10 immunoglobulin immunoglobulin NN cord-346321-drhiqch0 35 11 subclass subclass NN cord-346321-drhiqch0 35 12 and and CC cord-346321-drhiqch0 35 13 ADE ade NN cord-346321-drhiqch0 35 14 activity activity NN cord-346321-drhiqch0 35 15 of of IN cord-346321-drhiqch0 35 16 FIPV FIPV NNP cord-346321-drhiqch0 35 17 - - HYPH cord-346321-drhiqch0 35 18 neutralizing neutralize VBG cord-346321-drhiqch0 35 19 MAbs MAbs NNP cord-346321-drhiqch0 35 20 , , , cord-346321-drhiqch0 35 21 and and CC cord-346321-drhiqch0 35 22 attempted attempt VBD cord-346321-drhiqch0 35 23 to to TO cord-346321-drhiqch0 35 24 explore explore VB cord-346321-drhiqch0 35 25 mechanisms mechanism NNS cord-346321-drhiqch0 35 26 of of IN cord-346321-drhiqch0 35 27 ADE ADE NNP cord-346321-drhiqch0 35 28 of of IN cord-346321-drhiqch0 35 29 FIPV FIPV NNS cord-346321-drhiqch0 35 30 infection infection NN cord-346321-drhiqch0 35 31 in in IN cord-346321-drhiqch0 35 32 in in IN cord-346321-drhiqch0 35 33 vitro vitro FW cord-346321-drhiqch0 35 34 system system NN cord-346321-drhiqch0 35 35 using use VBG cord-346321-drhiqch0 35 36 mouse mouse NN cord-346321-drhiqch0 35 37 MAbs MAbs NNP cord-346321-drhiqch0 35 38 and and CC cord-346321-drhiqch0 35 39 feline feline JJ cord-346321-drhiqch0 35 40 alveolar alveolar NN cord-346321-drhiqch0 35 41 macrophages macrophage NNS cord-346321-drhiqch0 35 42 or or CC cord-346321-drhiqch0 35 43 human human JJ cord-346321-drhiqch0 35 44 monocytes monocyte NNS cord-346321-drhiqch0 35 45 . . . cord-346321-drhiqch0 36 1 FIPV FIPV NNS cord-346321-drhiqch0 36 2 strain strain VBP cord-346321-drhiqch0 36 3 79 79 CD cord-346321-drhiqch0 36 4 - - HYPH cord-346321-drhiqch0 36 5 1146 1146 CD cord-346321-drhiqch0 36 6 was be VBD cord-346321-drhiqch0 36 7 used use VBN cord-346321-drhiqch0 36 8 in in IN cord-346321-drhiqch0 36 9 this this DT cord-346321-drhiqch0 36 10 study study NN cord-346321-drhiqch0 36 11 . . . cord-346321-drhiqch0 37 1 This this DT cord-346321-drhiqch0 37 2 strain strain NN cord-346321-drhiqch0 37 3 was be VBD cord-346321-drhiqch0 37 4 kindly kindly RB cord-346321-drhiqch0 37 5 provided provide VBN cord-346321-drhiqch0 37 6 by by IN cord-346321-drhiqch0 37 7 Dr. Dr. NNP cord-346321-drhiqch0 37 8 M. M. NNP cord-346321-drhiqch0 37 9 C. C. NNP cord-346321-drhiqch0 37 10 Horzinek Horzinek NNP cord-346321-drhiqch0 37 11 of of IN cord-346321-drhiqch0 37 12 the the DT cord-346321-drhiqch0 37 13 State State NNP cord-346321-drhiqch0 37 14 University University NNP cord-346321-drhiqch0 37 15 Utrecht Utrecht NNP cord-346321-drhiqch0 37 16 , , , cord-346321-drhiqch0 37 17 the the DT cord-346321-drhiqch0 37 18 Netherlands Netherlands NNP cord-346321-drhiqch0 37 19 , , , cord-346321-drhiqch0 37 20 and and CC cord-346321-drhiqch0 37 21 was be VBD cord-346321-drhiqch0 37 22 passaged passage VBN cord-346321-drhiqch0 37 23 two two CD cord-346321-drhiqch0 37 24 or or CC cord-346321-drhiqch0 37 25 three three CD cord-346321-drhiqch0 37 26 times time NNS cord-346321-drhiqch0 37 27 in in IN cord-346321-drhiqch0 37 28 feline feline JJ cord-346321-drhiqch0 37 29 fetal fetal JJ cord-346321-drhiqch0 37 30 cell cell NN cord-346321-drhiqch0 37 31 ( ( -LRB- cord-346321-drhiqch0 37 32 fcwf-4 fcwf-4 NNP cord-346321-drhiqch0 37 33 ) ) -RRB- cord-346321-drhiqch0 37 34 cultures culture NNS cord-346321-drhiqch0 37 35 . . . cord-346321-drhiqch0 38 1 Feline feline JJ cord-346321-drhiqch0 38 2 alveolar alveolar NN cord-346321-drhiqch0 38 3 macrophages macrophage NNS cord-346321-drhiqch0 38 4 were be VBD cord-346321-drhiqch0 38 5 collected collect VBN cord-346321-drhiqch0 38 6 from from IN cord-346321-drhiqch0 38 7 anti anti JJ cord-346321-drhiqch0 38 8 - - JJ cord-346321-drhiqch0 38 9 coronavirus coronavirus JJ cord-346321-drhiqch0 38 10 antibody antibody NN cord-346321-drhiqch0 38 11 - - HYPH cord-346321-drhiqch0 38 12 negative negative JJ cord-346321-drhiqch0 38 13 adult adult NN cord-346321-drhiqch0 38 14 cats cat NNS cord-346321-drhiqch0 38 15 and and CC cord-346321-drhiqch0 38 16 cultured culture VBN cord-346321-drhiqch0 38 17 in in IN cord-346321-drhiqch0 38 18 Eagle Eagle NNP cord-346321-drhiqch0 38 19 's 's POS cord-346321-drhiqch0 38 20 minimum minimum JJ cord-346321-drhiqch0 38 21 essential essential JJ cord-346321-drhiqch0 38 22 medium medium NN cord-346321-drhiqch0 38 23 containing contain VBG cord-346321-drhiqch0 38 24 50~ 50~ CD cord-346321-drhiqch0 38 25 Leibovitz Leibovitz NNP cord-346321-drhiqch0 38 26 's 's POS cord-346321-drhiqch0 38 27 L-15 L-15 NNP cord-346321-drhiqch0 38 28 medium medium NN cord-346321-drhiqch0 38 29 , , , cord-346321-drhiqch0 38 30 10~ 10~ CD cord-346321-drhiqch0 38 31 fetal fetal JJ cord-346321-drhiqch0 38 32 calf calf NN cord-346321-drhiqch0 38 33 serum serum NN cord-346321-drhiqch0 38 34 , , , cord-346321-drhiqch0 38 35 100 100 CD cord-346321-drhiqch0 38 36 units unit NNS cord-346321-drhiqch0 38 37 of of IN cord-346321-drhiqch0 38 38 penicillin penicillin NN cord-346321-drhiqch0 38 39 per per IN cord-346321-drhiqch0 38 40 ml ml NN cord-346321-drhiqch0 38 41 and and CC cord-346321-drhiqch0 38 42 100 100 CD cord-346321-drhiqch0 38 43 ~tg ~tg NNS cord-346321-drhiqch0 38 44 of of IN cord-346321-drhiqch0 38 45 streptomycin streptomycin NNS cord-346321-drhiqch0 38 46 per per IN cord-346321-drhiqch0 38 47 ml ml NN cord-346321-drhiqch0 38 48 as as RB cord-346321-drhiqch0 38 49 previously previously RB cord-346321-drhiqch0 38 50 described describe VBN cord-346321-drhiqch0 38 51 [ [ -LRB- cord-346321-drhiqch0 38 52 12 12 CD cord-346321-drhiqch0 38 53 ] ] -RRB- cord-346321-drhiqch0 38 54 . . . cord-346321-drhiqch0 39 1 Human human JJ cord-346321-drhiqch0 39 2 monocyte monocyte JJ cord-346321-drhiqch0 39 3 cell cell NN cord-346321-drhiqch0 39 4 line line NN cord-346321-drhiqch0 39 5 U937 U937 NNP cord-346321-drhiqch0 39 6 was be VBD cord-346321-drhiqch0 39 7 kindly kindly RB cord-346321-drhiqch0 39 8 provided provide VBN cord-346321-drhiqch0 39 9 by by IN cord-346321-drhiqch0 39 10 Dr. Dr. NNP cord-346321-drhiqch0 39 11 J. J. NNP cord-346321-drhiqch0 39 12 Arikawa Arikawa NNP cord-346321-drhiqch0 39 13 of of IN cord-346321-drhiqch0 39 14 the the DT cord-346321-drhiqch0 39 15 University University NNP cord-346321-drhiqch0 39 16 of of IN cord-346321-drhiqch0 39 17 Hokkaido Hokkaido NNP cord-346321-drhiqch0 39 18 , , , cord-346321-drhiqch0 39 19 Japan Japan NNP cord-346321-drhiqch0 39 20 , , , cord-346321-drhiqch0 39 21 and and CC cord-346321-drhiqch0 39 22 was be VBD cord-346321-drhiqch0 39 23 cultured culture VBN cord-346321-drhiqch0 39 24 in in IN cord-346321-drhiqch0 39 25 RPMI RPMI NNP cord-346321-drhiqch0 39 26 1640 1640 CD cord-346321-drhiqch0 39 27 medium medium NN cord-346321-drhiqch0 39 28 containing contain VBG cord-346321-drhiqch0 39 29 10~o 10~o CD cord-346321-drhiqch0 39 30 fetal fetal JJ cord-346321-drhiqch0 39 31 calf calf NN cord-346321-drhiqch0 39 32 serum serum NN cord-346321-drhiqch0 39 33 , , , cord-346321-drhiqch0 39 34 100 100 CD cord-346321-drhiqch0 39 35 units unit NNS cord-346321-drhiqch0 39 36 of of IN cord-346321-drhiqch0 39 37 penicillin penicillin NN cord-346321-drhiqch0 39 38 per per IN cord-346321-drhiqch0 39 39 ml ml NN cord-346321-drhiqch0 39 40 and and CC cord-346321-drhiqch0 39 41 100 100 CD cord-346321-drhiqch0 39 42 ~tg ~tg NNS cord-346321-drhiqch0 39 43 of of IN cord-346321-drhiqch0 39 44 streptomycin streptomycin NNS cord-346321-drhiqch0 39 45 per per IN cord-346321-drhiqch0 39 46 ml ml NN cord-346321-drhiqch0 39 47 . . . cord-346321-drhiqch0 40 1 MAbs MAbs NNP cord-346321-drhiqch0 40 2 5 5 CD cord-346321-drhiqch0 40 3 - - SYM cord-346321-drhiqch0 40 4 6 6 CD cord-346321-drhiqch0 40 5 - - SYM cord-346321-drhiqch0 40 6 3 3 CD cord-346321-drhiqch0 40 7 , , , cord-346321-drhiqch0 40 8 5 5 CD cord-346321-drhiqch0 40 9 - - SYM cord-346321-drhiqch0 40 10 7 7 CD cord-346321-drhiqch0 40 11 - - SYM cord-346321-drhiqch0 40 12 2 2 CD cord-346321-drhiqch0 40 13 , , , cord-346321-drhiqch0 40 14 7-l 7-l CD cord-346321-drhiqch0 40 15 - - HYPH cord-346321-drhiqch0 40 16 l l NN cord-346321-drhiqch0 40 17 , , , cord-346321-drhiqch0 40 18 7 7 CD cord-346321-drhiqch0 40 19 - - SYM cord-346321-drhiqch0 40 20 3 3 CD cord-346321-drhiqch0 40 21 - - SYM cord-346321-drhiqch0 40 22 1 1 CD cord-346321-drhiqch0 40 23 , , , cord-346321-drhiqch0 40 24 6 6 CD cord-346321-drhiqch0 40 25 - - SYM cord-346321-drhiqch0 40 26 4 4 CD cord-346321-drhiqch0 40 27 - - SYM cord-346321-drhiqch0 40 28 2 2 CD cord-346321-drhiqch0 40 29 , , , cord-346321-drhiqch0 40 30 and and CC cord-346321-drhiqch0 40 31 6 6 CD cord-346321-drhiqch0 40 32 - - HYPH cord-346321-drhiqch0 40 33 1 1 CD cord-346321-drhiqch0 40 34 - - SYM cord-346321-drhiqch0 40 35 1 1 CD cord-346321-drhiqch0 40 36 used use VBN cord-346321-drhiqch0 40 37 in in IN cord-346321-drhiqch0 40 38 the the DT cord-346321-drhiqch0 40 39 present present JJ cord-346321-drhiqch0 40 40 study study NN cord-346321-drhiqch0 40 41 recognize recognize VBP cord-346321-drhiqch0 40 42 S S NNP cord-346321-drhiqch0 40 43 protein protein NN cord-346321-drhiqch0 40 44 of of IN cord-346321-drhiqch0 40 45 the the DT cord-346321-drhiqch0 40 46 virus virus NN cord-346321-drhiqch0 40 47 as as IN cord-346321-drhiqch0 40 48 demonstrated demonstrate VBN cord-346321-drhiqch0 40 49 by by IN cord-346321-drhiqch0 40 50 immunoblotting immunoblotte VBG cord-346321-drhiqch0 40 51 . . . cord-346321-drhiqch0 41 1 These these DT cord-346321-drhiqch0 41 2 MAbs MAbs NNP cord-346321-drhiqch0 41 3 have have VBP cord-346321-drhiqch0 41 4 the the DT cord-346321-drhiqch0 41 5 ability ability NN cord-346321-drhiqch0 41 6 to to TO cord-346321-drhiqch0 41 7 neutralize neutralize VB cord-346321-drhiqch0 41 8 FIPV FIPV NNP cord-346321-drhiqch0 41 9 strain strain VB cord-346321-drhiqch0 41 10 79 79 CD cord-346321-drhiqch0 41 11 - - SYM cord-346321-drhiqch0 41 12 1146 1146 CD cord-346321-drhiqch0 41 13 , , , cord-346321-drhiqch0 41 14 and and CC cord-346321-drhiqch0 41 15 recognize recognize VB cord-346321-drhiqch0 41 16 two two CD cord-346321-drhiqch0 41 17 different different JJ cord-346321-drhiqch0 41 18 antigenic antigenic JJ cord-346321-drhiqch0 41 19 sites site NNS cord-346321-drhiqch0 41 20 of of IN cord-346321-drhiqch0 41 21 the the DT cord-346321-drhiqch0 41 22 viral viral JJ cord-346321-drhiqch0 41 23 S S NNP cord-346321-drhiqch0 41 24 protein protein NN cord-346321-drhiqch0 41 25 [ [ -LRB- cord-346321-drhiqch0 41 26 11 11 CD cord-346321-drhiqch0 41 27 ] ] -RRB- cord-346321-drhiqch0 41 28 . . . cord-346321-drhiqch0 42 1 The the DT cord-346321-drhiqch0 42 2 neutralization neutralization NN cord-346321-drhiqch0 42 3 titer titer NN cord-346321-drhiqch0 42 4 , , , cord-346321-drhiqch0 42 5 indirect indirect JJ cord-346321-drhiqch0 42 6 immunoftuorescent immunoftuorescent NN cord-346321-drhiqch0 42 7 antibody antibody NN cord-346321-drhiqch0 42 8 titer titer NN cord-346321-drhiqch0 42 9 , , , cord-346321-drhiqch0 42 10 immunoglobulin immunoglobulin NN cord-346321-drhiqch0 42 11 isotype isotype NN cord-346321-drhiqch0 42 12 and and CC cord-346321-drhiqch0 42 13 epitope epitope NN cord-346321-drhiqch0 42 14 specificity specificity NN cord-346321-drhiqch0 42 15 of of IN cord-346321-drhiqch0 42 16 these these DT cord-346321-drhiqch0 42 17 MAbs MAbs NNP cord-346321-drhiqch0 42 18 are be VBP cord-346321-drhiqch0 42 19 shown show VBN cord-346321-drhiqch0 42 20 in in IN cord-346321-drhiqch0 42 21 Table Table NNP cord-346321-drhiqch0 42 22 1 1 CD cord-346321-drhiqch0 42 23 . . . cord-346321-drhiqch0 43 1 The the DT cord-346321-drhiqch0 43 2 culture culture NN cord-346321-drhiqch0 43 3 fluid fluid NN cord-346321-drhiqch0 43 4 of of IN cord-346321-drhiqch0 43 5 each each DT cord-346321-drhiqch0 43 6 MAb mab NN cord-346321-drhiqch0 43 7 - - HYPH cord-346321-drhiqch0 43 8 producing produce VBG cord-346321-drhiqch0 43 9 hybridoma hybridoma NN cord-346321-drhiqch0 43 10 was be VBD cord-346321-drhiqch0 43 11 used use VBN cord-346321-drhiqch0 43 12 for for IN cord-346321-drhiqch0 43 13 the the DT cord-346321-drhiqch0 43 14 experiment experiment NN cord-346321-drhiqch0 43 15 . . . cord-346321-drhiqch0 44 1 F(ab F(ab NNP cord-346321-drhiqch0 44 2 ' ' '' cord-346321-drhiqch0 44 3 ) ) -RRB- cord-346321-drhiqch0 44 4 2 2 CD cord-346321-drhiqch0 44 5 of of IN cord-346321-drhiqch0 44 6 MAb MAb NNS cord-346321-drhiqch0 44 7 32.2 32.2 CD cord-346321-drhiqch0 44 8 , , , cord-346321-drhiqch0 44 9 Fab Fab NNP cord-346321-drhiqch0 44 10 of of IN cord-346321-drhiqch0 44 11 MAb MAb NNPS cord-346321-drhiqch0 44 12 IV.3 IV.3 NNP cord-346321-drhiqch0 44 13 and and CC cord-346321-drhiqch0 44 14 F(ab F(ab NNP cord-346321-drhiqch0 44 15 ' ' '' cord-346321-drhiqch0 44 16 ) ) -RRB- cord-346321-drhiqch0 44 17 2 2 CD cord-346321-drhiqch0 44 18 of of IN cord-346321-drhiqch0 44 19 MAb MAb NNS cord-346321-drhiqch0 44 20 3G8 3g8 CD cord-346321-drhiqch0 44 21 were be VBD cord-346321-drhiqch0 44 22 purchased purchase VBN cord-346321-drhiqch0 44 23 from from IN cord-346321-drhiqch0 44 24 Medarex Medarex NNP cord-346321-drhiqch0 44 25 , , , cord-346321-drhiqch0 44 26 Lebanon Lebanon NNP cord-346321-drhiqch0 44 27 , , , cord-346321-drhiqch0 44 28 NH NH NNP cord-346321-drhiqch0 44 29 . . . cord-346321-drhiqch0 45 1 MAb MAb NNS cord-346321-drhiqch0 45 2 32.2 32.2 CD cord-346321-drhiqch0 45 3 is be VBZ cord-346321-drhiqch0 45 4 a a DT cord-346321-drhiqch0 45 5 mouse mouse NN cord-346321-drhiqch0 45 6 IgG igg NN cord-346321-drhiqch0 45 7 1 1 CD cord-346321-drhiqch0 45 8 antibody antibody NN cord-346321-drhiqch0 45 9 that that WDT cord-346321-drhiqch0 45 10 reacts react VBZ cord-346321-drhiqch0 45 11 with with IN cord-346321-drhiqch0 45 12 human human JJ cord-346321-drhiqch0 45 13 Fc7 fc7 NN cord-346321-drhiqch0 45 14 R r NN cord-346321-drhiqch0 45 15 I i NN cord-346321-drhiqch0 45 16 [ [ -LRB- cord-346321-drhiqch0 45 17 1 1 CD cord-346321-drhiqch0 45 18 ] ] -RRB- cord-346321-drhiqch0 45 19 . . . cord-346321-drhiqch0 46 1 MAb MAb NNS cord-346321-drhiqch0 46 2 IV.3 IV.3 NNP cord-346321-drhiqch0 46 3 is be VBZ cord-346321-drhiqch0 46 4 a a DT cord-346321-drhiqch0 46 5 mouse mouse NN cord-346321-drhiqch0 46 6 IgG IgG NNP cord-346321-drhiqch0 46 7 2b 2b NNP cord-346321-drhiqch0 46 8 antibody antibody NNP cord-346321-drhiqch0 46 9 that that WDT cord-346321-drhiqch0 46 10 reacts react VBZ cord-346321-drhiqch0 46 11 with with IN cord-346321-drhiqch0 46 12 human human JJ cord-346321-drhiqch0 46 13 Fc7 fc7 NN cord-346321-drhiqch0 46 14 R R NNP cord-346321-drhiqch0 46 15 II II NNP cord-346321-drhiqch0 46 16 [ [ -LRB- cord-346321-drhiqch0 46 17 15 15 CD cord-346321-drhiqch0 46 18 ] ] -RRB- cord-346321-drhiqch0 46 19 . . . cord-346321-drhiqch0 47 1 MAb MAb NNS cord-346321-drhiqch0 47 2 3G8 3g8 CD cord-346321-drhiqch0 47 3 is be VBZ cord-346321-drhiqch0 47 4 a a DT cord-346321-drhiqch0 47 5 mouse mouse NN cord-346321-drhiqch0 47 6 IgG igg NN cord-346321-drhiqch0 47 7 1 1 CD cord-346321-drhiqch0 47 8 antibody antibody NN cord-346321-drhiqch0 47 9 that that WDT cord-346321-drhiqch0 47 10 reacts react VBZ cord-346321-drhiqch0 47 11 with with IN cord-346321-drhiqch0 47 12 human human JJ cord-346321-drhiqch0 47 13 Fc Fc NNP cord-346321-drhiqch0 47 14 ? ? . cord-346321-drhiqch0 48 1 R R NNP cord-346321-drhiqch0 48 2 III III NNP cord-346321-drhiqch0 48 3 [ [ -LRB- cord-346321-drhiqch0 48 4 6 6 CD cord-346321-drhiqch0 48 5 ] ] -RRB- cord-346321-drhiqch0 48 6 . . . cord-346321-drhiqch0 49 1 A a DT cord-346321-drhiqch0 49 2 mixture mixture NN cord-346321-drhiqch0 49 3 of of IN cord-346321-drhiqch0 49 4 MAbs MAbs NNP cord-346321-drhiqch0 49 5 that that WDT cord-346321-drhiqch0 49 6 recognize recognize VBP cord-346321-drhiqch0 49 7 peplomer peplomer JJ cord-346321-drhiqch0 49 8 protein protein NN cord-346321-drhiqch0 49 9 ( ( -LRB- cord-346321-drhiqch0 49 10 S S NNP cord-346321-drhiqch0 49 11 ) ) -RRB- cord-346321-drhiqch0 49 12 , , , cord-346321-drhiqch0 49 13 transmembrane transmembrane NN cord-346321-drhiqch0 49 14 protein protein NN cord-346321-drhiqch0 49 15 ( ( -LRB- cord-346321-drhiqch0 49 16 M M NNP cord-346321-drhiqch0 49 17 ) ) -RRB- cord-346321-drhiqch0 49 18 and and CC cord-346321-drhiqch0 49 19 nucleocapsid nucleocapsid NNP cord-346321-drhiqch0 49 20 protein protein NNP cord-346321-drhiqch0 49 21 ( ( -LRB- cord-346321-drhiqch0 49 22 N N NNP cord-346321-drhiqch0 49 23 ) ) -RRB- cord-346321-drhiqch0 49 24 of of IN cord-346321-drhiqch0 49 25 FIPV FIPV NNP cord-346321-drhiqch0 49 26 strain strain VBP cord-346321-drhiqch0 49 27 79 79 CD cord-346321-drhiqch0 49 28 - - SYM cord-346321-drhiqch0 49 29 1146 1146 CD cord-346321-drhiqch0 49 30 , , , cord-346321-drhiqch0 49 31 respectively respectively RB cord-346321-drhiqch0 49 32 , , , cord-346321-drhiqch0 49 33 was be VBD cord-346321-drhiqch0 49 34 used use VBN cord-346321-drhiqch0 49 35 as as IN cord-346321-drhiqch0 49 36 the the DT cord-346321-drhiqch0 49 37 primary primary JJ cord-346321-drhiqch0 49 38 antibody antibody NN cord-346321-drhiqch0 49 39 . . . cord-346321-drhiqch0 50 1 The the DT cord-346321-drhiqch0 50 2 MAbs MAbs NNP cord-346321-drhiqch0 50 3 were be VBD cord-346321-drhiqch0 50 4 added add VBN cord-346321-drhiqch0 50 5 to to IN cord-346321-drhiqch0 50 6 acetone acetone NN cord-346321-drhiqch0 50 7 - - HYPH cord-346321-drhiqch0 50 8 fixed fix VBN cord-346321-drhiqch0 50 9 FIPV FIPV NNS cord-346321-drhiqch0 50 10 - - HYPH cord-346321-drhiqch0 50 11 infected infect VBN cord-346321-drhiqch0 50 12 cells cell NNS cord-346321-drhiqch0 50 13 and and CC cord-346321-drhiqch0 50 14 allowed allow VBN cord-346321-drhiqch0 50 15 to to TO cord-346321-drhiqch0 50 16 stand stand VB cord-346321-drhiqch0 50 17 at at IN cord-346321-drhiqch0 50 18 37 37 CD cord-346321-drhiqch0 50 19 ° ° NN cord-346321-drhiqch0 50 20 C c NN cord-346321-drhiqch0 50 21 for for IN cord-346321-drhiqch0 50 22 30 30 CD cord-346321-drhiqch0 50 23 rain rain NN cord-346321-drhiqch0 50 24 . . . cord-346321-drhiqch0 51 1 After after IN cord-346321-drhiqch0 51 2 the the DT cord-346321-drhiqch0 51 3 specimens specimen NNS cord-346321-drhiqch0 51 4 were be VBD cord-346321-drhiqch0 51 5 washed wash VBN cord-346321-drhiqch0 51 6 with with IN cord-346321-drhiqch0 51 7 phosphate phosphate NN cord-346321-drhiqch0 51 8 - - HYPH cord-346321-drhiqch0 51 9 buffered buffer VBN cord-346321-drhiqch0 51 10 saline saline NN cord-346321-drhiqch0 51 11 ( ( -LRB- cord-346321-drhiqch0 51 12 PBS PBS NNP cord-346321-drhiqch0 51 13 ) ) -RRB- cord-346321-drhiqch0 51 14 three three CD cord-346321-drhiqch0 51 15 times time NNS cord-346321-drhiqch0 51 16 , , , cord-346321-drhiqch0 51 17 they -PRON- PRP cord-346321-drhiqch0 51 18 were be VBD cord-346321-drhiqch0 51 19 stained stain VBN cord-346321-drhiqch0 51 20 with with IN cord-346321-drhiqch0 51 21 rabbit rabbit NN cord-346321-drhiqch0 51 22 anti anti JJ cord-346321-drhiqch0 51 23 - - JJ cord-346321-drhiqch0 51 24 mouse mouse JJ cord-346321-drhiqch0 51 25 IgG IgG NNP cord-346321-drhiqch0 51 26 , , , cord-346321-drhiqch0 51 27 IgA IgA NNP cord-346321-drhiqch0 51 28 and and CC cord-346321-drhiqch0 51 29 IgM IgM NNP cord-346321-drhiqch0 51 30 serum serum NNP cord-346321-drhiqch0 51 31 conjugated conjugate VBN cord-346321-drhiqch0 51 32 with with IN cord-346321-drhiqch0 51 33 fluorescein fluorescein NN cord-346321-drhiqch0 51 34 isothiocyanate isothiocyanate NN cord-346321-drhiqch0 51 35 ( ( -LRB- cord-346321-drhiqch0 51 36 Miles Miles NNP cord-346321-drhiqch0 51 37 Laboratories Laboratories NNPS cord-346321-drhiqch0 51 38 , , , cord-346321-drhiqch0 51 39 Naperville Naperville NNP cord-346321-drhiqch0 51 40 , , , cord-346321-drhiqch0 51 41 U.S.A U.S.A NNP cord-346321-drhiqch0 51 42 ) ) -RRB- cord-346321-drhiqch0 51 43 . . . cord-346321-drhiqch0 52 1 After after IN cord-346321-drhiqch0 52 2 being be VBG cord-346321-drhiqch0 52 3 held hold VBN cord-346321-drhiqch0 52 4 at at IN cord-346321-drhiqch0 52 5 37 37 CD cord-346321-drhiqch0 52 6 ° ° NN cord-346321-drhiqch0 52 7 C c NN cord-346321-drhiqch0 52 8 for for IN cord-346321-drhiqch0 52 9 30min 30min NN cord-346321-drhiqch0 52 10 , , , cord-346321-drhiqch0 52 11 they -PRON- PRP cord-346321-drhiqch0 52 12 were be VBD cord-346321-drhiqch0 52 13 washed wash VBN cord-346321-drhiqch0 52 14 with with IN cord-346321-drhiqch0 52 15 PBS PBS NNP cord-346321-drhiqch0 52 16 , , , cord-346321-drhiqch0 52 17 mounted mount VBN cord-346321-drhiqch0 52 18 in in IN cord-346321-drhiqch0 52 19 50~ 50~ CD cord-346321-drhiqch0 52 20 glycerol glycerol NN cord-346321-drhiqch0 52 21 buffer buffer NN cord-346321-drhiqch0 52 22 and and CC cord-346321-drhiqch0 52 23 observed observe VBD cord-346321-drhiqch0 52 24 under under IN cord-346321-drhiqch0 52 25 a a DT cord-346321-drhiqch0 52 26 fluorescence fluorescence NN cord-346321-drhiqch0 52 27 microscope microscope NN cord-346321-drhiqch0 52 28 . . . cord-346321-drhiqch0 53 1 Confluent Confluent NNP cord-346321-drhiqch0 53 2 fcwf-4 fcwf-4 NNP cord-346321-drhiqch0 53 3 cell cell NN cord-346321-drhiqch0 53 4 monolayers monolayer NNS cord-346321-drhiqch0 53 5 in in IN cord-346321-drhiqch0 53 6 60-min 60-min CD cord-346321-drhiqch0 53 7 plastic plastic JJ cord-346321-drhiqch0 53 8 petri petri JJ cord-346321-drhiqch0 53 9 dishes dish NNS cord-346321-drhiqch0 53 10 were be VBD cord-346321-drhiqch0 53 11 inoculated inoculate VBN cord-346321-drhiqch0 53 12 with with IN cord-346321-drhiqch0 53 13 virus virus NN cord-346321-drhiqch0 53 14 dilutions dilution NNS cord-346321-drhiqch0 53 15 of of IN cord-346321-drhiqch0 53 16 specimen specimen NN cord-346321-drhiqch0 53 17 to to TO cord-346321-drhiqch0 53 18 be be VB cord-346321-drhiqch0 53 19 assayed assay VBN cord-346321-drhiqch0 53 20 for for IN cord-346321-drhiqch0 53 21 amount amount NN cord-346321-drhiqch0 53 22 of of IN cord-346321-drhiqch0 53 23 infectious infectious JJ cord-346321-drhiqch0 53 24 virus virus NN cord-346321-drhiqch0 53 25 in in IN cord-346321-drhiqch0 53 26 0.1 0.1 CD cord-346321-drhiqch0 53 27 ml ml NN cord-346321-drhiqch0 53 28 amounts amount NNS cord-346321-drhiqch0 53 29 . . . cord-346321-drhiqch0 54 1 After after IN cord-346321-drhiqch0 54 2 virus virus NN cord-346321-drhiqch0 54 3 adsorption adsorption NN cord-346321-drhiqch0 54 4 at at IN cord-346321-drhiqch0 54 5 37 37 CD cord-346321-drhiqch0 54 6 ° ° NN cord-346321-drhiqch0 54 7 C c NN cord-346321-drhiqch0 54 8 for for IN cord-346321-drhiqch0 54 9 60rain 60rain CD cord-346321-drhiqch0 54 10 , , , cord-346321-drhiqch0 54 11 the the DT cord-346321-drhiqch0 54 12 inoculated inoculate VBN cord-346321-drhiqch0 54 13 cultures culture NNS cord-346321-drhiqch0 54 14 were be VBD cord-346321-drhiqch0 54 15 covered cover VBN cord-346321-drhiqch0 54 16 with with IN cord-346321-drhiqch0 54 17 5 5 CD cord-346321-drhiqch0 54 18 ml ml NNS cord-346321-drhiqch0 54 19 of of IN cord-346321-drhiqch0 54 20 agar agar NNP cord-346321-drhiqch0 54 21 overlay overlay NN cord-346321-drhiqch0 54 22 medium medium NN cord-346321-drhiqch0 54 23 which which WDT cord-346321-drhiqch0 54 24 consisted consist VBD cord-346321-drhiqch0 54 25 of of IN cord-346321-drhiqch0 54 26 1~o 1~o CD cord-346321-drhiqch0 54 27 Bacto Bacto NNP cord-346321-drhiqch0 54 28 agar agar NN cord-346321-drhiqch0 54 29 in in IN cord-346321-drhiqch0 54 30 minimal minimal JJ cord-346321-drhiqch0 54 31 essential essential JJ cord-346321-drhiqch0 54 32 medium medium NN cord-346321-drhiqch0 54 33 . . . cord-346321-drhiqch0 55 1 The the DT cord-346321-drhiqch0 55 2 cultures culture NNS cord-346321-drhiqch0 55 3 were be VBD cord-346321-drhiqch0 55 4 incubated incubate VBN cord-346321-drhiqch0 55 5 in in IN cord-346321-drhiqch0 55 6 a a DT cord-346321-drhiqch0 55 7 CO2 CO2 NNP cord-346321-drhiqch0 55 8 incubator incubator NN cord-346321-drhiqch0 55 9 at at IN cord-346321-drhiqch0 55 10 37 37 CD cord-346321-drhiqch0 55 11 ° ° NN cord-346321-drhiqch0 55 12 C c NN cord-346321-drhiqch0 55 13 for for IN cord-346321-drhiqch0 55 14 2 2 CD cord-346321-drhiqch0 55 15 days day NNS cord-346321-drhiqch0 55 16 , , , cord-346321-drhiqch0 55 17 and and CC cord-346321-drhiqch0 55 18 stained stain VBN cord-346321-drhiqch0 55 19 by by IN cord-346321-drhiqch0 55 20 incubating incubate VBG cord-346321-drhiqch0 55 21 at at IN cord-346321-drhiqch0 55 22 37 37 CD cord-346321-drhiqch0 55 23 ° ° NN cord-346321-drhiqch0 55 24 C c NN cord-346321-drhiqch0 55 25 for for IN cord-346321-drhiqch0 55 26 6 6 CD cord-346321-drhiqch0 55 27 h h NN cord-346321-drhiqch0 55 28 under under IN cord-346321-drhiqch0 55 29 a a DT cord-346321-drhiqch0 55 30 second second JJ cord-346321-drhiqch0 55 31 overlay overlay NN cord-346321-drhiqch0 55 32 medium medium NN cord-346321-drhiqch0 55 33 containing contain VBG cord-346321-drhiqch0 55 34 0.01~o 0.01~o CD cord-346321-drhiqch0 55 35 neutral neutral JJ cord-346321-drhiqch0 55 36 red red NN cord-346321-drhiqch0 55 37 . . . cord-346321-drhiqch0 56 1 The the DT cord-346321-drhiqch0 56 2 infectious infectious JJ cord-346321-drhiqch0 56 3 titer titer NN cord-346321-drhiqch0 56 4 was be VBD cord-346321-drhiqch0 56 5 expressed express VBN cord-346321-drhiqch0 56 6 in in IN cord-346321-drhiqch0 56 7 plaque plaque NN cord-346321-drhiqch0 56 8 - - HYPH cord-346321-drhiqch0 56 9 forming form VBG cord-346321-drhiqch0 56 10 units unit NNS cord-346321-drhiqch0 56 11 ( ( -LRB- cord-346321-drhiqch0 56 12 PFU pfu NN cord-346321-drhiqch0 56 13 ) ) -RRB- cord-346321-drhiqch0 56 14 . . . cord-346321-drhiqch0 57 1 ADE ADE NNP cord-346321-drhiqch0 57 2 assay assay NN cord-346321-drhiqch0 57 3 of of IN cord-346321-drhiqch0 57 4 FIPV FIPV NNS cord-346321-drhiqch0 57 5 infection infection NN cord-346321-drhiqch0 57 6 of of IN cord-346321-drhiqch0 57 7 feline feline JJ cord-346321-drhiqch0 57 8 alveolar alveolar NN cord-346321-drhiqch0 57 9 macrophages macrophage NNS cord-346321-drhiqch0 57 10 was be VBD cord-346321-drhiqch0 57 11 performed perform VBN cord-346321-drhiqch0 57 12 by by IN cord-346321-drhiqch0 57 13 two two CD cord-346321-drhiqch0 57 14 methods method NNS cord-346321-drhiqch0 57 15 . . . cord-346321-drhiqch0 58 1 In in IN cord-346321-drhiqch0 58 2 the the DT cord-346321-drhiqch0 58 3 first first JJ cord-346321-drhiqch0 58 4 method method NN cord-346321-drhiqch0 58 5 , , , cord-346321-drhiqch0 58 6 equal equal JJ cord-346321-drhiqch0 58 7 amounts amount NNS cord-346321-drhiqch0 58 8 of of IN cord-346321-drhiqch0 58 9 MAb MAb NNS cord-346321-drhiqch0 58 10 and and CC cord-346321-drhiqch0 58 11 viral viral JJ cord-346321-drhiqch0 58 12 suspension suspension NN cord-346321-drhiqch0 58 13 were be VBD cord-346321-drhiqch0 58 14 allowed allow VBN cord-346321-drhiqch0 58 15 to to TO cord-346321-drhiqch0 58 16 react react VB cord-346321-drhiqch0 58 17 at at IN cord-346321-drhiqch0 58 18 276 276 CD cord-346321-drhiqch0 58 19 T. T. NNP cord-346321-drhiqch0 58 20 Hohdatsu Hohdatsu NNP cord-346321-drhiqch0 58 21 et et NNP cord-346321-drhiqch0 58 22 al al NNP cord-346321-drhiqch0 58 23 . . . cord-346321-drhiqch0 59 1 4 4 LS cord-346321-drhiqch0 59 2 ° ° NN cord-346321-drhiqch0 59 3 C c NN cord-346321-drhiqch0 59 4 for for IN cord-346321-drhiqch0 59 5 1 1 CD cord-346321-drhiqch0 59 6 h h NN cord-346321-drhiqch0 59 7 before before IN cord-346321-drhiqch0 59 8 inoculation inoculation NN cord-346321-drhiqch0 59 9 onto onto IN cord-346321-drhiqch0 59 10 the the DT cord-346321-drhiqch0 59 11 macrophages macrophage NNS cord-346321-drhiqch0 59 12 . . . cord-346321-drhiqch0 60 1 In in IN cord-346321-drhiqch0 60 2 the the DT cord-346321-drhiqch0 60 3 second second JJ cord-346321-drhiqch0 60 4 method method NN cord-346321-drhiqch0 60 5 , , , cord-346321-drhiqch0 60 6 MAbs MAbs NNP cord-346321-drhiqch0 60 7 alone alone RB cord-346321-drhiqch0 60 8 were be VBD cord-346321-drhiqch0 60 9 allowed allow VBN cord-346321-drhiqch0 60 10 to to TO cord-346321-drhiqch0 60 11 react react VB cord-346321-drhiqch0 60 12 with with IN cord-346321-drhiqch0 60 13 the the DT cord-346321-drhiqch0 60 14 macrophages macrophage NNS cord-346321-drhiqch0 60 15 at at IN cord-346321-drhiqch0 60 16 37 37 CD cord-346321-drhiqch0 60 17 ° ° NN cord-346321-drhiqch0 60 18 C c NN cord-346321-drhiqch0 60 19 for for IN cord-346321-drhiqch0 60 20 1 1 CD cord-346321-drhiqch0 60 21 h h NN cord-346321-drhiqch0 60 22 before before IN cord-346321-drhiqch0 60 23 viral viral JJ cord-346321-drhiqch0 60 24 inoculation inoculation NN cord-346321-drhiqch0 60 25 . . . cord-346321-drhiqch0 61 1 In in IN cord-346321-drhiqch0 61 2 both both DT cord-346321-drhiqch0 61 3 methods method NNS cord-346321-drhiqch0 61 4 , , , cord-346321-drhiqch0 61 5 the the DT cord-346321-drhiqch0 61 6 virus virus NN cord-346321-drhiqch0 61 7 - - HYPH cord-346321-drhiqch0 61 8 inoculated inoculate VBN cord-346321-drhiqch0 61 9 cells cell NNS cord-346321-drhiqch0 61 10 were be VBD cord-346321-drhiqch0 61 11 examined examine VBN cord-346321-drhiqch0 61 12 for for IN cord-346321-drhiqch0 61 13 viral viral JJ cord-346321-drhiqch0 61 14 antigen antigen NN cord-346321-drhiqch0 61 15 by by IN cord-346321-drhiqch0 61 16 IFA IFA NNP cord-346321-drhiqch0 61 17 using use VBG cord-346321-drhiqch0 61 18 mixture mixture NN cord-346321-drhiqch0 61 19 of of IN cord-346321-drhiqch0 61 20 anti anti JJ cord-346321-drhiqch0 61 21 - - NNP cord-346321-drhiqch0 61 22 FIPV FIPV NNP cord-346321-drhiqch0 61 23 MAbs MAbs NNP cord-346321-drhiqch0 61 24 after after IN cord-346321-drhiqch0 61 25 incubation incubation NN cord-346321-drhiqch0 61 26 for for IN cord-346321-drhiqch0 61 27 36h 36h CD cord-346321-drhiqch0 61 28 , , , cord-346321-drhiqch0 61 29 and and CC cord-346321-drhiqch0 61 30 the the DT cord-346321-drhiqch0 61 31 percent percent NN cord-346321-drhiqch0 61 32 of of IN cord-346321-drhiqch0 61 33 ADE ADE NNP cord-346321-drhiqch0 61 34 was be VBD cord-346321-drhiqch0 61 35 determined determine VBN cord-346321-drhiqch0 61 36 by by IN cord-346321-drhiqch0 61 37 the the DT cord-346321-drhiqch0 61 38 following following JJ cord-346321-drhiqch0 61 39 formula formula NN cord-346321-drhiqch0 61 40 : : : cord-346321-drhiqch0 61 41 where where WRB cord-346321-drhiqch0 61 42 A a DT cord-346321-drhiqch0 61 43 is be VBZ cord-346321-drhiqch0 61 44 the the DT cord-346321-drhiqch0 61 45 rate rate NN cord-346321-drhiqch0 61 46 of of IN cord-346321-drhiqch0 61 47 IFA IFA NNP cord-346321-drhiqch0 61 48 positive positive JJ cord-346321-drhiqch0 61 49 cells cell NNS cord-346321-drhiqch0 61 50 in in IN cord-346321-drhiqch0 61 51 the the DT cord-346321-drhiqch0 61 52 culture culture NN cord-346321-drhiqch0 61 53 infected infect VBN cord-346321-drhiqch0 61 54 in in IN cord-346321-drhiqch0 61 55 the the DT cord-346321-drhiqch0 61 56 presence presence NN cord-346321-drhiqch0 61 57 of of IN cord-346321-drhiqch0 61 58 MAb MAb NNS cord-346321-drhiqch0 61 59 and and CC cord-346321-drhiqch0 61 60 B b NN cord-346321-drhiqch0 61 61 is be VBZ cord-346321-drhiqch0 61 62 that that IN cord-346321-drhiqch0 61 63 in in IN cord-346321-drhiqch0 61 64 the the DT cord-346321-drhiqch0 61 65 culture culture NN cord-346321-drhiqch0 61 66 infected infect VBN cord-346321-drhiqch0 61 67 in in IN cord-346321-drhiqch0 61 68 the the DT cord-346321-drhiqch0 61 69 absence absence NN cord-346321-drhiqch0 61 70 of of IN cord-346321-drhiqch0 61 71 MAb MAb NNS cord-346321-drhiqch0 61 72 . . . cord-346321-drhiqch0 62 1 In in IN cord-346321-drhiqch0 62 2 ADE ADE NNP cord-346321-drhiqch0 62 3 assay assay NN cord-346321-drhiqch0 62 4 of of IN cord-346321-drhiqch0 62 5 FIPV FIPV NNS cord-346321-drhiqch0 62 6 infection infection NN cord-346321-drhiqch0 62 7 of of IN cord-346321-drhiqch0 62 8 human human JJ cord-346321-drhiqch0 62 9 monocyte monocyte NNP cord-346321-drhiqch0 62 10 cell cell NN cord-346321-drhiqch0 62 11 line line NN cord-346321-drhiqch0 62 12 U937 U937 NNP cord-346321-drhiqch0 62 13 , , , cord-346321-drhiqch0 62 14 virus virus NN cord-346321-drhiqch0 62 15 suspension suspension NN cord-346321-drhiqch0 62 16 was be VBD cord-346321-drhiqch0 62 17 allowed allow VBN cord-346321-drhiqch0 62 18 to to TO cord-346321-drhiqch0 62 19 react react VB cord-346321-drhiqch0 62 20 with with IN cord-346321-drhiqch0 62 21 MAb MAb NNS cord-346321-drhiqch0 62 22 at at IN cord-346321-drhiqch0 62 23 4 4 CD cord-346321-drhiqch0 62 24 ° ° NN cord-346321-drhiqch0 62 25 C c NN cord-346321-drhiqch0 62 26 for for IN cord-346321-drhiqch0 62 27 1 1 CD cord-346321-drhiqch0 62 28 h h NN cord-346321-drhiqch0 62 29 and and CC cord-346321-drhiqch0 62 30 then then RB cord-346321-drhiqch0 62 31 inoculated inoculate VBD cord-346321-drhiqch0 62 32 to to IN cord-346321-drhiqch0 62 33 a a DT cord-346321-drhiqch0 62 34 cell cell NN cord-346321-drhiqch0 62 35 pellet pellet NN cord-346321-drhiqch0 62 36 of of IN cord-346321-drhiqch0 62 37 U937 U937 NNP cord-346321-drhiqch0 62 38 cells cell NNS cord-346321-drhiqch0 62 39 . . . cord-346321-drhiqch0 63 1 The the DT cord-346321-drhiqch0 63 2 inoculated inoculate VBN cord-346321-drhiqch0 63 3 cells cell NNS cord-346321-drhiqch0 63 4 were be VBD cord-346321-drhiqch0 63 5 incubated incubate VBN cord-346321-drhiqch0 63 6 at at IN cord-346321-drhiqch0 63 7 37 37 CD cord-346321-drhiqch0 63 8 ° ° NN cord-346321-drhiqch0 63 9 C c NN cord-346321-drhiqch0 63 10 for for IN cord-346321-drhiqch0 63 11 1 1 CD cord-346321-drhiqch0 63 12 h h NN cord-346321-drhiqch0 63 13 to to TO cord-346321-drhiqch0 63 14 allow allow VB cord-346321-drhiqch0 63 15 virus virus NN cord-346321-drhiqch0 63 16 adsorption adsorption NN cord-346321-drhiqch0 63 17 , , , cord-346321-drhiqch0 63 18 and and CC cord-346321-drhiqch0 63 19 then then RB cord-346321-drhiqch0 63 20 washed wash VBD cord-346321-drhiqch0 63 21 with with IN cord-346321-drhiqch0 63 22 Hanks Hanks NNP cord-346321-drhiqch0 63 23 ' ' POS cord-346321-drhiqch0 63 24 balanced balanced JJ cord-346321-drhiqch0 63 25 salt salt NN cord-346321-drhiqch0 63 26 solution solution NN cord-346321-drhiqch0 63 27 ( ( -LRB- cord-346321-drhiqch0 63 28 HBSS HBSS NNP cord-346321-drhiqch0 63 29 ) ) -RRB- cord-346321-drhiqch0 63 30 . . . cord-346321-drhiqch0 64 1 After after IN cord-346321-drhiqch0 64 2 washing washing NN cord-346321-drhiqch0 64 3 , , , cord-346321-drhiqch0 64 4 the the DT cord-346321-drhiqch0 64 5 cells cell NNS cord-346321-drhiqch0 64 6 were be VBD cord-346321-drhiqch0 64 7 cultured cultured JJ cord-346321-drhiqch0 64 8 and and CC cord-346321-drhiqch0 64 9 36 36 CD cord-346321-drhiqch0 64 10 h h NN cord-346321-drhiqch0 64 11 later later RB cord-346321-drhiqch0 64 12 , , , cord-346321-drhiqch0 64 13 were be VBD cord-346321-drhiqch0 64 14 examined examine VBN cord-346321-drhiqch0 64 15 for for IN cord-346321-drhiqch0 64 16 infecting infect VBG cord-346321-drhiqch0 64 17 FIPV FIPV NNP cord-346321-drhiqch0 64 18 antigen antigen NN cord-346321-drhiqch0 64 19 by by IN cord-346321-drhiqch0 64 20 IFA IFA NNP cord-346321-drhiqch0 64 21 . . . cord-346321-drhiqch0 65 1 At at IN cord-346321-drhiqch0 65 2 the the DT cord-346321-drhiqch0 65 3 same same JJ cord-346321-drhiqch0 65 4 time time NN cord-346321-drhiqch0 65 5 , , , cord-346321-drhiqch0 65 6 the the DT cord-346321-drhiqch0 65 7 level level NN cord-346321-drhiqch0 65 8 of of IN cord-346321-drhiqch0 65 9 infectious infectious JJ cord-346321-drhiqch0 65 10 virus virus NN cord-346321-drhiqch0 65 11 in in IN cord-346321-drhiqch0 65 12 the the DT cord-346321-drhiqch0 65 13 culture culture NN cord-346321-drhiqch0 65 14 supernatant supernatant NN cord-346321-drhiqch0 65 15 was be VBD cord-346321-drhiqch0 65 16 determined determine VBN cord-346321-drhiqch0 65 17 by by IN cord-346321-drhiqch0 65 18 plaque plaque NN cord-346321-drhiqch0 65 19 assay assay NN cord-346321-drhiqch0 65 20 . . . cord-346321-drhiqch0 66 1 Undiluted undiluted JJ cord-346321-drhiqch0 66 2 MAb MAb NNS cord-346321-drhiqch0 66 3 ( ( -LRB- cord-346321-drhiqch0 66 4 5 5 CD cord-346321-drhiqch0 66 5 - - SYM cord-346321-drhiqch0 66 6 6 6 CD cord-346321-drhiqch0 66 7 - - SYM cord-346321-drhiqch0 66 8 2 2 CD cord-346321-drhiqch0 66 9 , , , cord-346321-drhiqch0 66 10 5 5 CD cord-346321-drhiqch0 66 11 - - SYM cord-346321-drhiqch0 66 12 7 7 CD cord-346321-drhiqch0 66 13 - - SYM cord-346321-drhiqch0 66 14 2 2 CD cord-346321-drhiqch0 66 15 , , , cord-346321-drhiqch0 66 16 7 7 CD cord-346321-drhiqch0 66 17 - - SYM cord-346321-drhiqch0 66 18 1 1 CD cord-346321-drhiqch0 66 19 - - SYM cord-346321-drhiqch0 66 20 1 1 CD cord-346321-drhiqch0 66 21 , , , cord-346321-drhiqch0 66 22 7 7 CD cord-346321-drhiqch0 66 23 - - SYM cord-346321-drhiqch0 66 24 3 3 CD cord-346321-drhiqch0 66 25 - - SYM cord-346321-drhiqch0 66 26 1 1 CD cord-346321-drhiqch0 66 27 , , , cord-346321-drhiqch0 66 28 6 6 CD cord-346321-drhiqch0 66 29 - - SYM cord-346321-drhiqch0 66 30 4 4 CD cord-346321-drhiqch0 66 31 - - SYM cord-346321-drhiqch0 66 32 2 2 CD cord-346321-drhiqch0 66 33 or or CC cord-346321-drhiqch0 66 34 6 6 CD cord-346321-drhiqch0 66 35 - - HYPH cord-346321-drhiqch0 66 36 1 1 CD cord-346321-drhiqch0 66 37 - - HYPH cord-346321-drhiqch0 66 38 1 1 CD cord-346321-drhiqch0 66 39 ) ) -RRB- cord-346321-drhiqch0 66 40 or or CC cord-346321-drhiqch0 66 41 a a DT cord-346321-drhiqch0 66 42 mixture mixture NN cord-346321-drhiqch0 66 43 of of IN cord-346321-drhiqch0 66 44 either either DT cord-346321-drhiqch0 66 45 one one CD cord-346321-drhiqch0 66 46 of of IN cord-346321-drhiqch0 66 47 the the DT cord-346321-drhiqch0 66 48 MAb MAb NNS cord-346321-drhiqch0 66 49 and and CC cord-346321-drhiqch0 66 50 FIPV FIPV NNP cord-346321-drhiqch0 66 51 was be VBD cord-346321-drhiqch0 66 52 added add VBN cord-346321-drhiqch0 66 53 to to IN cord-346321-drhiqch0 66 54 1 1 CD cord-346321-drhiqch0 66 55 x x SYM cord-346321-drhiqch0 66 56 10 10 CD cord-346321-drhiqch0 66 57 6 6 CD cord-346321-drhiqch0 66 58 feline feline JJ cord-346321-drhiqch0 66 59 alveolar alveolar NN cord-346321-drhiqch0 66 60 macrophages macrophage NNS cord-346321-drhiqch0 66 61 and and CC cord-346321-drhiqch0 66 62 held hold VBD cord-346321-drhiqch0 66 63 at at IN cord-346321-drhiqch0 66 64 4 4 CD cord-346321-drhiqch0 66 65 ° ° NN cord-346321-drhiqch0 66 66 C c NN cord-346321-drhiqch0 66 67 for for IN cord-346321-drhiqch0 66 68 1 1 CD cord-346321-drhiqch0 66 69 h. h. NN cord-346321-drhiqch0 67 1 After after IN cord-346321-drhiqch0 67 2 three three CD cord-346321-drhiqch0 67 3 washings washing NNS cord-346321-drhiqch0 67 4 with with IN cord-346321-drhiqch0 67 5 HBSS HBSS NNP cord-346321-drhiqch0 67 6 containing contain VBG cord-346321-drhiqch0 67 7 0.1 0.1 CD cord-346321-drhiqch0 67 8 % % NN cord-346321-drhiqch0 67 9 N n CD cord-346321-drhiqch0 67 10 , , , cord-346321-drhiqch0 67 11 N3 N3 NNP cord-346321-drhiqch0 67 12 , , , cord-346321-drhiqch0 67 13 the the DT cord-346321-drhiqch0 67 14 cells cell NNS cord-346321-drhiqch0 67 15 were be VBD cord-346321-drhiqch0 67 16 allowed allow VBN cord-346321-drhiqch0 67 17 to to TO cord-346321-drhiqch0 67 18 react react VB cord-346321-drhiqch0 67 19 with with IN cord-346321-drhiqch0 67 20 8-fold 8-fold JJ cord-346321-drhiqch0 67 21 diluted diluted JJ cord-346321-drhiqch0 67 22 FITC fitc NN cord-346321-drhiqch0 67 23 - - HYPH cord-346321-drhiqch0 67 24 conjugated conjugate VBN cord-346321-drhiqch0 67 25 Fab Fab NNP cord-346321-drhiqch0 67 26 of of IN cord-346321-drhiqch0 67 27 goat goat NN cord-346321-drhiqch0 67 28 anti anti JJ cord-346321-drhiqch0 67 29 - - JJ cord-346321-drhiqch0 67 30 mouse mouse JJ cord-346321-drhiqch0 67 31 IgG IgG NNP cord-346321-drhiqch0 67 32 antibody antibody NN cord-346321-drhiqch0 67 33 at at IN cord-346321-drhiqch0 67 34 4 4 CD cord-346321-drhiqch0 67 35 ° ° NN cord-346321-drhiqch0 67 36 C c NN cord-346321-drhiqch0 67 37 for for IN cord-346321-drhiqch0 67 38 1 1 CD cord-346321-drhiqch0 67 39 h. h. NN cord-346321-drhiqch0 67 40 After after IN cord-346321-drhiqch0 67 41 being be VBG cord-346321-drhiqch0 67 42 washed wash VBN cord-346321-drhiqch0 67 43 three three CD cord-346321-drhiqch0 67 44 times time NNS cord-346321-drhiqch0 67 45 , , , cord-346321-drhiqch0 67 46 the the DT cord-346321-drhiqch0 67 47 stained stained JJ cord-346321-drhiqch0 67 48 cells cell NNS cord-346321-drhiqch0 67 49 were be VBD cord-346321-drhiqch0 67 50 analyzed analyze VBN cord-346321-drhiqch0 67 51 by by IN cord-346321-drhiqch0 67 52 counting count VBG cord-346321-drhiqch0 67 53 about about IN cord-346321-drhiqch0 67 54 10,000 10,000 CD cord-346321-drhiqch0 67 55 cells cell NNS cord-346321-drhiqch0 67 56 on on IN cord-346321-drhiqch0 67 57 a a DT cord-346321-drhiqch0 67 58 FACS FACS NNP cord-346321-drhiqch0 67 59 440 440 CD cord-346321-drhiqch0 68 1 ( ( -LRB- cord-346321-drhiqch0 68 2 Becton Becton NNP cord-346321-drhiqch0 68 3 Dickinson Dickinson NNP cord-346321-drhiqch0 68 4 Co. Co. NNP cord-346321-drhiqch0 68 5 , , , cord-346321-drhiqch0 68 6 U.S.A. U.S.A. NNP cord-346321-drhiqch0 68 7 ) ) -RRB- cord-346321-drhiqch0 68 8 . . . cord-346321-drhiqch0 68 9 _SP cord-346321-drhiqch0 69 1 The the DT cord-346321-drhiqch0 69 2 relationship relationship NN cord-346321-drhiqch0 69 3 between between IN cord-346321-drhiqch0 69 4 Ig Ig NNP cord-346321-drhiqch0 69 5 subclass subclass NN cord-346321-drhiqch0 69 6 and and CC cord-346321-drhiqch0 69 7 A a NN cord-346321-drhiqch0 69 8 D d NN cord-346321-drhiqch0 69 9 E e NN cord-346321-drhiqch0 69 10 activity activity NN cord-346321-drhiqch0 69 11 was be VBD cord-346321-drhiqch0 69 12 investigated investigate VBN cord-346321-drhiqch0 69 13 with with IN cord-346321-drhiqch0 69 14 the the DT cord-346321-drhiqch0 69 15 M M NNP cord-346321-drhiqch0 69 16 A A NNP cord-346321-drhiqch0 69 17 b b NN cord-346321-drhiqch0 69 18 s s NN cord-346321-drhiqch0 69 19 shown show VBN cord-346321-drhiqch0 69 20 in in IN cord-346321-drhiqch0 69 21 Table Table NNP cord-346321-drhiqch0 69 22 1 1 CD cord-346321-drhiqch0 69 23 . . . cord-346321-drhiqch0 70 1 As as IN cord-346321-drhiqch0 70 2 shown show VBN cord-346321-drhiqch0 70 3 in in IN cord-346321-drhiqch0 70 4 Fig Fig NNP cord-346321-drhiqch0 70 5 . . . cord-346321-drhiqch0 71 1 1 1 LS cord-346321-drhiqch0 71 2 , , , cord-346321-drhiqch0 71 3 despite despite IN cord-346321-drhiqch0 71 4 the the DT cord-346321-drhiqch0 71 5 fact fact NN cord-346321-drhiqch0 71 6 that that IN cord-346321-drhiqch0 71 7 they -PRON- PRP cord-346321-drhiqch0 71 8 A a DT cord-346321-drhiqch0 71 9 D d NN cord-346321-drhiqch0 71 10 E e NN cord-346321-drhiqch0 71 11 activity activity NN cord-346321-drhiqch0 71 12 of of IN cord-346321-drhiqch0 71 13 these these DT cord-346321-drhiqch0 71 14 M M NNP cord-346321-drhiqch0 71 15 A A NNP cord-346321-drhiqch0 71 16 b b NN cord-346321-drhiqch0 71 17 s s NN cord-346321-drhiqch0 71 18 was be VBD cord-346321-drhiqch0 71 19 also also RB cord-346321-drhiqch0 71 20 determined determine VBN cord-346321-drhiqch0 71 21 by by IN cord-346321-drhiqch0 71 22 inoculating inoculate VBG cord-346321-drhiqch0 71 23 F f NN cord-346321-drhiqch0 71 24 I i NN cord-346321-drhiqch0 71 25 P p NN cord-346321-drhiqch0 71 26 V v NN cord-346321-drhiqch0 71 27 to to IN cord-346321-drhiqch0 71 28 macrophages macrophage NNS cord-346321-drhiqch0 71 29 pretreated pretreate VBN cord-346321-drhiqch0 71 30 with with IN cord-346321-drhiqch0 71 31 each each DT cord-346321-drhiqch0 71 32 M M NNP cord-346321-drhiqch0 71 33 A A NNP cord-346321-drhiqch0 71 34 b b NN cord-346321-drhiqch0 71 35 ( ( -LRB- cord-346321-drhiqch0 71 36 Fig Fig NNP cord-346321-drhiqch0 71 37 . . NNP cord-346321-drhiqch0 71 38 2 2 CD cord-346321-drhiqch0 71 39 ) ) -RRB- cord-346321-drhiqch0 71 40 . . . cord-346321-drhiqch0 72 1 M M NNP cord-346321-drhiqch0 72 2 A A NNP cord-346321-drhiqch0 72 3 b b NN cord-346321-drhiqch0 72 4 s s NN cord-346321-drhiqch0 72 5 5 5 CD cord-346321-drhiqch0 72 6 - - SYM cord-346321-drhiqch0 72 7 7 7 CD cord-346321-drhiqch0 72 8 - - SYM cord-346321-drhiqch0 72 9 2 2 CD cord-346321-drhiqch0 72 10 , , , cord-346321-drhiqch0 72 11 7 7 CD cord-346321-drhiqch0 72 12 - - SYM cord-346321-drhiqch0 72 13 1 1 CD cord-346321-drhiqch0 72 14 - - SYM cord-346321-drhiqch0 72 15 1 1 CD cord-346321-drhiqch0 72 16 and and CC cord-346321-drhiqch0 72 17 6 6 CD cord-346321-drhiqch0 72 18 - - SYM cord-346321-drhiqch0 72 19 4 4 CD cord-346321-drhiqch0 72 20 - - SYM cord-346321-drhiqch0 72 21 2 2 CD cord-346321-drhiqch0 72 22 , , , cord-346321-drhiqch0 73 1 whose whose WP$ cord-346321-drhiqch0 73 2 subclass subclass NN cord-346321-drhiqch0 73 3 is be VBZ cord-346321-drhiqch0 73 4 I i NN cord-346321-drhiqch0 73 5 g g NN cord-346321-drhiqch0 73 6 G g NN cord-346321-drhiqch0 73 7 2a 2a CD cord-346321-drhiqch0 73 8 , , , cord-346321-drhiqch0 73 9 enhanced enhance VBD cord-346321-drhiqch0 73 10 the the DT cord-346321-drhiqch0 73 11 infection infection NN cord-346321-drhiqch0 73 12 in in IN cord-346321-drhiqch0 73 13 the the DT cord-346321-drhiqch0 73 14 same same JJ cord-346321-drhiqch0 73 15 way way NN cord-346321-drhiqch0 73 16 as as IN cord-346321-drhiqch0 73 17 in in IN cord-346321-drhiqch0 73 18 the the DT cord-346321-drhiqch0 73 19 case case NN cord-346321-drhiqch0 73 20 when when WRB cord-346321-drhiqch0 73 21 mixture mixture NN cord-346321-drhiqch0 73 22 of of IN cord-346321-drhiqch0 73 23 F f NN cord-346321-drhiqch0 73 24 I i NN cord-346321-drhiqch0 73 25 P p NN cord-346321-drhiqch0 73 26 V v NN cord-346321-drhiqch0 73 27 and and CC cord-346321-drhiqch0 73 28 M M NNP cord-346321-drhiqch0 73 29 A A NNP cord-346321-drhiqch0 73 30 b b NN cord-346321-drhiqch0 73 31 was be VBD cord-346321-drhiqch0 73 32 inoculated inoculate VBN cord-346321-drhiqch0 73 33 to to IN cord-346321-drhiqch0 73 34 macrophages macrophage NNS cord-346321-drhiqch0 73 35 . . . cord-346321-drhiqch0 74 1 In in IN cord-346321-drhiqch0 74 2 contrast contrast NN cord-346321-drhiqch0 74 3 , , , cord-346321-drhiqch0 74 4 none none NN cord-346321-drhiqch0 74 5 of of IN cord-346321-drhiqch0 74 6 the the DT cord-346321-drhiqch0 74 7 subclass subclass NN cord-346321-drhiqch0 74 8 IgG IgG NNP cord-346321-drhiqch0 74 9 1 1 CD cord-346321-drhiqch0 74 10 MAbs MAbs NNP cord-346321-drhiqch0 74 11 ( ( -LRB- cord-346321-drhiqch0 74 12 5 5 CD cord-346321-drhiqch0 74 13 - - SYM cord-346321-drhiqch0 74 14 6 6 CD cord-346321-drhiqch0 74 15 - - SYM cord-346321-drhiqch0 74 16 2 2 CD cord-346321-drhiqch0 74 17 , , , cord-346321-drhiqch0 74 18 7 7 CD cord-346321-drhiqch0 74 19 - - SYM cord-346321-drhiqch0 74 20 3 3 CD cord-346321-drhiqch0 74 21 - - SYM cord-346321-drhiqch0 74 22 1 1 CD cord-346321-drhiqch0 74 23 and and CC cord-346321-drhiqch0 74 24 6 6 CD cord-346321-drhiqch0 74 25 - - HYPH cord-346321-drhiqch0 74 26 1 1 CD cord-346321-drhiqch0 74 27 - - SYM cord-346321-drhiqch0 74 28 1 1 CD cord-346321-drhiqch0 74 29 ) ) -RRB- cord-346321-drhiqch0 74 30 showed show VBD cord-346321-drhiqch0 74 31 ADE ADE NNP cord-346321-drhiqch0 74 32 activity activity NN cord-346321-drhiqch0 74 33 ( ( -LRB- cord-346321-drhiqch0 74 34 Fig Fig NNP cord-346321-drhiqch0 74 35 . . NNP cord-346321-drhiqch0 74 36 2 2 CD cord-346321-drhiqch0 74 37 ) ) -RRB- cord-346321-drhiqch0 74 38 . . . cord-346321-drhiqch0 75 1 These these DT cord-346321-drhiqch0 75 2 results result NNS cord-346321-drhiqch0 75 3 , , , cord-346321-drhiqch0 75 4 together together RB cord-346321-drhiqch0 75 5 with with IN cord-346321-drhiqch0 75 6 those those DT cord-346321-drhiqch0 75 7 shown show VBN cord-346321-drhiqch0 75 8 in in IN cord-346321-drhiqch0 75 9 Fig Fig NNP cord-346321-drhiqch0 75 10 . . . cord-346321-drhiqch0 76 1 1 1 LS cord-346321-drhiqch0 76 2 , , , cord-346321-drhiqch0 76 3 clearly clearly RB cord-346321-drhiqch0 76 4 indicate indicate VBP cord-346321-drhiqch0 76 5 the the DT cord-346321-drhiqch0 76 6 relationship relationship NN cord-346321-drhiqch0 76 7 between between IN cord-346321-drhiqch0 76 8 Ig Ig NNP cord-346321-drhiqch0 76 9 subclass subclass NN cord-346321-drhiqch0 76 10 of of IN cord-346321-drhiqch0 76 11 MAbs MAbs NNP cord-346321-drhiqch0 76 12 and and CC cord-346321-drhiqch0 76 13 the the DT cord-346321-drhiqch0 76 14 ADE ADE NNP cord-346321-drhiqch0 76 15 activity activity NN cord-346321-drhiqch0 76 16 . . . cord-346321-drhiqch0 77 1 Binding bind VBG cord-346321-drhiqch0 77 2 of of IN cord-346321-drhiqch0 77 3 mouse mouse NN cord-346321-drhiqch0 77 4 anti anti NNP cord-346321-drhiqch0 77 5 - - NNP cord-346321-drhiqch0 77 6 FIPV FIPV NNP cord-346321-drhiqch0 77 7 MAbs MAbs NNP cord-346321-drhiqch0 77 8 to to IN cord-346321-drhiqch0 77 9 the the DT cord-346321-drhiqch0 77 10 Fc Fc NNP cord-346321-drhiqch0 77 11 7 7 CD cord-346321-drhiqch0 77 12 R r NN cord-346321-drhiqch0 77 13 on on IN cord-346321-drhiqch0 77 14 feline feline JJ cord-346321-drhiqch0 77 15 alveolar alveolar NN cord-346321-drhiqch0 77 16 macrophages macrophage NNS cord-346321-drhiqch0 77 17 was be VBD cord-346321-drhiqch0 77 18 determined determine VBN cord-346321-drhiqch0 77 19 by by IN cord-346321-drhiqch0 77 20 indirect indirect JJ cord-346321-drhiqch0 77 21 immunofluorescence immunofluorescence NN cord-346321-drhiqch0 77 22 flow flow NN cord-346321-drhiqch0 77 23 cytometry cytometry NN cord-346321-drhiqch0 77 24 of of IN cord-346321-drhiqch0 77 25 the the DT cord-346321-drhiqch0 77 26 MAbtreated mabtreated JJ cord-346321-drhiqch0 77 27 macrophages macrophage NNS cord-346321-drhiqch0 77 28 . . . cord-346321-drhiqch0 78 1 Figure figure NN cord-346321-drhiqch0 78 2 3A 3a NN cord-346321-drhiqch0 78 3 shows show VBZ cord-346321-drhiqch0 78 4 the the DT cord-346321-drhiqch0 78 5 percentages percentage NNS cord-346321-drhiqch0 78 6 of of IN cord-346321-drhiqch0 78 7 positively positively RB cord-346321-drhiqch0 78 8 stained stain VBN cord-346321-drhiqch0 78 9 cells cell NNS cord-346321-drhiqch0 78 10 in in IN cord-346321-drhiqch0 78 11 the the DT cord-346321-drhiqch0 78 12 macrophages macrophage NNS cord-346321-drhiqch0 78 13 treated treat VBN cord-346321-drhiqch0 78 14 with with IN cord-346321-drhiqch0 78 15 different different JJ cord-346321-drhiqch0 78 16 MAb MAb NNS cord-346321-drhiqch0 78 17 . . . cord-346321-drhiqch0 79 1 Percentage percentage NN cord-346321-drhiqch0 79 2 of of IN cord-346321-drhiqch0 79 3 the the DT cord-346321-drhiqch0 79 4 stained stained JJ cord-346321-drhiqch0 79 5 macrophages macrophage NNS cord-346321-drhiqch0 79 6 which which WDT cord-346321-drhiqch0 79 7 had have VBD cord-346321-drhiqch0 79 8 been be VBN cord-346321-drhiqch0 79 9 treated treat VBN cord-346321-drhiqch0 79 10 with with IN cord-346321-drhiqch0 79 11 either either DT cord-346321-drhiqch0 79 12 one one CD cord-346321-drhiqch0 79 13 of of IN cord-346321-drhiqch0 79 14 the the DT cord-346321-drhiqch0 79 15 IgG IgG NNP cord-346321-drhiqch0 79 16 t t NNP cord-346321-drhiqch0 79 17 MAbs MAbs NNP cord-346321-drhiqch0 79 18 was be VBD cord-346321-drhiqch0 79 19 very very RB cord-346321-drhiqch0 79 20 low low JJ cord-346321-drhiqch0 79 21 and and CC cord-346321-drhiqch0 79 22 almost almost RB cord-346321-drhiqch0 79 23 the the DT cord-346321-drhiqch0 79 24 same same JJ cord-346321-drhiqch0 79 25 as as IN cord-346321-drhiqch0 79 26 that that DT cord-346321-drhiqch0 79 27 of of IN cord-346321-drhiqch0 79 28 control control NN cord-346321-drhiqch0 79 29 macrophages macrophage NNS cord-346321-drhiqch0 79 30 which which WDT cord-346321-drhiqch0 79 31 had have VBD cord-346321-drhiqch0 79 32 been be VBN cord-346321-drhiqch0 79 33 treated treat VBN cord-346321-drhiqch0 79 34 with with IN cord-346321-drhiqch0 79 35 HBSS HBSS NNP cord-346321-drhiqch0 79 36 instead instead RB cord-346321-drhiqch0 79 37 of of IN cord-346321-drhiqch0 79 38 MAb MAb NNS cord-346321-drhiqch0 79 39 . . . cord-346321-drhiqch0 80 1 In in IN cord-346321-drhiqch0 80 2 contrast contrast NN cord-346321-drhiqch0 80 3 , , , cord-346321-drhiqch0 80 4 percentage percentage NN cord-346321-drhiqch0 80 5 of of IN cord-346321-drhiqch0 80 6 the the DT cord-346321-drhiqch0 80 7 stained stained JJ cord-346321-drhiqch0 80 8 macrophages macrophage NNS cord-346321-drhiqch0 80 9 which which WDT cord-346321-drhiqch0 80 10 had have VBD cord-346321-drhiqch0 80 11 been be VBN cord-346321-drhiqch0 80 12 treated treat VBN cord-346321-drhiqch0 80 13 with with IN cord-346321-drhiqch0 80 14 either either DT cord-346321-drhiqch0 80 15 one one CD cord-346321-drhiqch0 80 16 of of IN cord-346321-drhiqch0 80 17 the the DT cord-346321-drhiqch0 80 18 IgG IgG NNP cord-346321-drhiqch0 80 19 2a 2a NNP cord-346321-drhiqch0 80 20 MAbs MAbs NNP cord-346321-drhiqch0 80 21 was be VBD cord-346321-drhiqch0 80 22 distinctly distinctly RB cord-346321-drhiqch0 80 23 increased• increased• JJ cord-346321-drhiqch0 80 24 Figure figure NN cord-346321-drhiqch0 80 25 3B 3b NN cord-346321-drhiqch0 80 26 Next Next NNP cord-346321-drhiqch0 80 27 , , , cord-346321-drhiqch0 80 28 to to TO cord-346321-drhiqch0 80 29 determine determine VB cord-346321-drhiqch0 80 30 ADE ADE NNP cord-346321-drhiqch0 80 31 by by IN cord-346321-drhiqch0 80 32 mouse mouse NN cord-346321-drhiqch0 80 33 anti anti NNP cord-346321-drhiqch0 80 34 - - NNP cord-346321-drhiqch0 80 35 FIPV FIPV NNP cord-346321-drhiqch0 80 36 MAbs MAbs NNP cord-346321-drhiqch0 80 37 of of IN cord-346321-drhiqch0 80 38 F F NNP cord-346321-drhiqch0 80 39 I i NN cord-346321-drhiqch0 80 40 P p NN cord-346321-drhiqch0 80 41 V v NN cord-346321-drhiqch0 80 42 infection infection NN cord-346321-drhiqch0 80 43 in in IN cord-346321-drhiqch0 80 44 h h NN cord-346321-drhiqch0 80 45 u u NNP cord-346321-drhiqch0 80 46 m m NNP cord-346321-drhiqch0 80 47 a a NNP cord-346321-drhiqch0 80 48 n n NN cord-346321-drhiqch0 80 49 U937 U937 NNP cord-346321-drhiqch0 80 50 cells cell NNS cord-346321-drhiqch0 80 51 , , , cord-346321-drhiqch0 80 52 F F NNP cord-346321-drhiqch0 80 53 I i NN cord-346321-drhiqch0 80 54 P p NN cord-346321-drhiqch0 80 55 V v NN cord-346321-drhiqch0 80 56 alone alone RB cord-346321-drhiqch0 80 57 or or CC cord-346321-drhiqch0 80 58 a a DT cord-346321-drhiqch0 80 59 mixture mixture NN cord-346321-drhiqch0 80 60 of of IN cord-346321-drhiqch0 80 61 F f NN cord-346321-drhiqch0 80 62 I i NN cord-346321-drhiqch0 80 63 P p NN cord-346321-drhiqch0 80 64 V v NN cord-346321-drhiqch0 80 65 and and CC cord-346321-drhiqch0 80 66 either either DT cord-346321-drhiqch0 80 67 one one CD cord-346321-drhiqch0 80 68 of of IN cord-346321-drhiqch0 80 69 the the DT cord-346321-drhiqch0 80 70 MAbs MAbs NNP cord-346321-drhiqch0 80 71 was be VBD cord-346321-drhiqch0 80 72 inoculated inoculate VBN cord-346321-drhiqch0 80 73 to to IN cord-346321-drhiqch0 80 74 U937 u937 CD cord-346321-drhiqch0 80 75 cells cell NNS cord-346321-drhiqch0 80 76 . . . cord-346321-drhiqch0 81 1 The the DT cord-346321-drhiqch0 81 2 inoculated inoculate VBN cord-346321-drhiqch0 81 3 cells cell NNS cord-346321-drhiqch0 81 4 were be VBD cord-346321-drhiqch0 81 5 cultured cultured JJ cord-346321-drhiqch0 81 6 , , , cord-346321-drhiqch0 81 7 and and CC cord-346321-drhiqch0 81 8 36 36 CD cord-346321-drhiqch0 81 9 h h NN cord-346321-drhiqch0 81 10 later later RB cord-346321-drhiqch0 81 11 , , , cord-346321-drhiqch0 81 12 viral viral JJ cord-346321-drhiqch0 81 13 proliferation proliferation NN cord-346321-drhiqch0 81 14 was be VBD cord-346321-drhiqch0 81 15 assessed assess VBN cord-346321-drhiqch0 81 16 by by IN cord-346321-drhiqch0 81 17 IFA IFA NNP cord-346321-drhiqch0 81 18 of of IN cord-346321-drhiqch0 81 19 the the DT cord-346321-drhiqch0 81 20 cells cell NNS cord-346321-drhiqch0 81 21 with with IN cord-346321-drhiqch0 81 22 mixture mixture NN cord-346321-drhiqch0 81 23 of of IN cord-346321-drhiqch0 81 24 anti anti JJ cord-346321-drhiqch0 81 25 - - NNP cord-346321-drhiqch0 81 26 FIPV FIPV NNP cord-346321-drhiqch0 81 27 MAbs MAbs NNP cord-346321-drhiqch0 81 28 and and CC cord-346321-drhiqch0 81 29 virus virus NN cord-346321-drhiqch0 81 30 plaque plaque NN cord-346321-drhiqch0 81 31 assay assay NN cord-346321-drhiqch0 81 32 of of IN cord-346321-drhiqch0 81 33 the the DT cord-346321-drhiqch0 81 34 culture culture NN cord-346321-drhiqch0 81 35 supernatant supernatant JJ cord-346321-drhiqch0 81 36 . . . cord-346321-drhiqch0 82 1 In in IN cord-346321-drhiqch0 82 2 Table Table NNP cord-346321-drhiqch0 82 3 2 2 CD cord-346321-drhiqch0 82 4 , , , cord-346321-drhiqch0 82 5 when when WRB cord-346321-drhiqch0 82 6 F F NNP cord-346321-drhiqch0 82 7 I i NN cord-346321-drhiqch0 82 8 P p NN cord-346321-drhiqch0 82 9 V v NN cord-346321-drhiqch0 82 10 alone alone RB cord-346321-drhiqch0 82 11 was be VBD cord-346321-drhiqch0 82 12 inoculated inoculate VBN cord-346321-drhiqch0 82 13 to to IN cord-346321-drhiqch0 82 14 U937 u937 CD cord-346321-drhiqch0 82 15 cells cell NNS cord-346321-drhiqch0 82 16 , , , cord-346321-drhiqch0 82 17 viral viral JJ cord-346321-drhiqch0 82 18 proliferation proliferation NN cord-346321-drhiqch0 82 19 did do VBD cord-346321-drhiqch0 82 20 not not RB cord-346321-drhiqch0 82 21 occur occur VB cord-346321-drhiqch0 82 22 at at RB cord-346321-drhiqch0 82 23 all all RB cord-346321-drhiqch0 82 24 , , , cord-346321-drhiqch0 82 25 whereas whereas IN cord-346321-drhiqch0 82 26 it -PRON- PRP cord-346321-drhiqch0 82 27 occurred occur VBD cord-346321-drhiqch0 82 28 when when WRB cord-346321-drhiqch0 82 29 the the DT cord-346321-drhiqch0 82 30 virus virus NN cord-346321-drhiqch0 82 31 complexed complexe VBN cord-346321-drhiqch0 82 32 with with IN cord-346321-drhiqch0 82 33 either either DT cord-346321-drhiqch0 82 34 one one CD cord-346321-drhiqch0 82 35 of of IN cord-346321-drhiqch0 82 36 the the DT cord-346321-drhiqch0 82 37 MAbs MAbs NNP cord-346321-drhiqch0 82 38 was be VBD cord-346321-drhiqch0 82 39 inoculated inoculate VBN cord-346321-drhiqch0 82 40 . . . cord-346321-drhiqch0 83 1 Notably notably RB cord-346321-drhiqch0 83 2 , , , cord-346321-drhiqch0 83 3 F f NN cord-346321-drhiqch0 83 4 I i NN cord-346321-drhiqch0 83 5 P p NN cord-346321-drhiqch0 83 6 V v NN cord-346321-drhiqch0 83 7 infection infection NN cord-346321-drhiqch0 83 8 was be VBD cord-346321-drhiqch0 83 9 established establish VBN cord-346321-drhiqch0 83 10 in in IN cord-346321-drhiqch0 83 11 U937 U937 NNP cord-346321-drhiqch0 83 12 cells cell NNS cord-346321-drhiqch0 83 13 even even RB cord-346321-drhiqch0 83 14 with with IN cord-346321-drhiqch0 83 15 the the DT cord-346321-drhiqch0 83 16 IgG igg NN cord-346321-drhiqch0 83 17 1 1 CD cord-346321-drhiqch0 83 18 MAbs MAbs NNP cord-346321-drhiqch0 83 19 that that WDT cord-346321-drhiqch0 83 20 did do VBD cord-346321-drhiqch0 83 21 not not RB cord-346321-drhiqch0 83 22 show show VB cord-346321-drhiqch0 83 23 A a DT cord-346321-drhiqch0 83 24 D d NN cord-346321-drhiqch0 83 25 E e NN cord-346321-drhiqch0 83 26 of of IN cord-346321-drhiqch0 83 27 the the DT cord-346321-drhiqch0 83 28 infection infection NN cord-346321-drhiqch0 83 29 in in IN cord-346321-drhiqch0 83 30 feline feline JJ cord-346321-drhiqch0 83 31 macrophages macrophage NNS cord-346321-drhiqch0 83 32 , , , cord-346321-drhiqch0 83 33 even even RB cord-346321-drhiqch0 83 34 though though IN cord-346321-drhiqch0 83 35 the the DT cord-346321-drhiqch0 83 36 degree degree NN cord-346321-drhiqch0 83 37 of of IN cord-346321-drhiqch0 83 38 the the DT cord-346321-drhiqch0 83 39 A A NNP cord-346321-drhiqch0 83 40 D d NN cord-346321-drhiqch0 83 41 E e NN cord-346321-drhiqch0 83 42 was be VBD cord-346321-drhiqch0 83 43 far far RB cord-346321-drhiqch0 83 44 less less JJR cord-346321-drhiqch0 83 45 than than IN cord-346321-drhiqch0 83 46 that that DT cord-346321-drhiqch0 83 47 by by IN cord-346321-drhiqch0 83 48 the the DT cord-346321-drhiqch0 83 49 IgG IgG NNP cord-346321-drhiqch0 83 50 2a 2a NNP cord-346321-drhiqch0 83 51 MAbs MAbs NNP cord-346321-drhiqch0 83 52 . . . cord-346321-drhiqch0 83 53 _SP cord-346321-drhiqch0 84 1 In in IN cord-346321-drhiqch0 84 2 vitro vitro FW cord-346321-drhiqch0 84 3 studies study NNS cord-346321-drhiqch0 84 4 using use VBG cord-346321-drhiqch0 84 5 a a DT cord-346321-drhiqch0 84 6 n n NN cord-346321-drhiqch0 84 7 t t NN cord-346321-drhiqch0 85 1 i i PRP cord-346321-drhiqch0 85 2 -F -f ADD cord-346321-drhiqch0 86 1 I i NN cord-346321-drhiqch0 86 2 P p NN cord-346321-drhiqch0 86 3 V V NNP cord-346321-drhiqch0 86 4 MAbs MAbs NNP cord-346321-drhiqch0 86 5 and and CC cord-346321-drhiqch0 86 6 in in IN cord-346321-drhiqch0 86 7 vivo vivo NNP cord-346321-drhiqch0 86 8 studies study NNS cord-346321-drhiqch0 86 9 of of IN cord-346321-drhiqch0 86 10 cats cat NNS cord-346321-drhiqch0 86 11 immunized immunize VBN cord-346321-drhiqch0 86 12 with with IN cord-346321-drhiqch0 86 13 recombinant recombinant JJ cord-346321-drhiqch0 86 14 vaccinia vaccinia NN cord-346321-drhiqch0 86 15 virus virus NN cord-346321-drhiqch0 86 16 expressing express VBG cord-346321-drhiqch0 87 1 F F NNP cord-346321-drhiqch0 87 2 I i NN cord-346321-drhiqch0 87 3 P p NN cord-346321-drhiqch0 87 4 V v NN cord-346321-drhiqch0 87 5 S s NN cord-346321-drhiqch0 87 6 protein protein NN cord-346321-drhiqch0 87 7 have have VBP cord-346321-drhiqch0 87 8 indicated indicate VBN cord-346321-drhiqch0 87 9 that that DT cord-346321-drhiqch0 87 10 antibody antibody NN cord-346321-drhiqch0 87 11 against against IN cord-346321-drhiqch0 87 12 F F NNP cord-346321-drhiqch0 87 13 I I NNP cord-346321-drhiqch0 87 14 P p NN cord-346321-drhiqch0 87 15 V v NN cord-346321-drhiqch0 87 16 S s NN cord-346321-drhiqch0 87 17 protein protein NN cord-346321-drhiqch0 87 18 induces induce VBZ cord-346321-drhiqch0 87 19 A a DT cord-346321-drhiqch0 87 20 D d NN cord-346321-drhiqch0 87 21 E e NN cord-346321-drhiqch0 87 22 of of IN cord-346321-drhiqch0 87 23 F f NN cord-346321-drhiqch0 87 24 I i NN cord-346321-drhiqch0 87 25 P p NN cord-346321-drhiqch0 87 26 V v NN cord-346321-drhiqch0 87 27 infection infection NN cord-346321-drhiqch0 87 28 [ [ -LRB- cord-346321-drhiqch0 87 29 5 5 CD cord-346321-drhiqch0 87 30 , , , cord-346321-drhiqch0 87 31 12 12 CD cord-346321-drhiqch0 87 32 , , , cord-346321-drhiqch0 87 33 13 13 CD cord-346321-drhiqch0 87 34 , , , cord-346321-drhiqch0 87 35 19 19 CD cord-346321-drhiqch0 87 36 , , , cord-346321-drhiqch0 87 37 20 20 CD cord-346321-drhiqch0 87 38 , , , cord-346321-drhiqch0 87 39 33 33 CD cord-346321-drhiqch0 87 40 ] ] -RRB- cord-346321-drhiqch0 87 41 . . . cord-346321-drhiqch0 88 1 Some some DT cord-346321-drhiqch0 88 2 studies study NNS cord-346321-drhiqch0 88 3 showed show VBD cord-346321-drhiqch0 88 4 that that IN cord-346321-drhiqch0 88 5 MAbs MAbs NNP cord-346321-drhiqch0 88 6 having have VBG cord-346321-drhiqch0 88 7 virus virus NN cord-346321-drhiqch0 88 8 neutralizing neutralize VBG cord-346321-drhiqch0 88 9 activity activity NN cord-346321-drhiqch0 88 10 caused cause VBD cord-346321-drhiqch0 88 11 intense intense JJ cord-346321-drhiqch0 88 12 A a NN cord-346321-drhiqch0 88 13 D d NN cord-346321-drhiqch0 88 14 E e NN cord-346321-drhiqch0 88 15 of of IN cord-346321-drhiqch0 88 16 F f NN cord-346321-drhiqch0 88 17 I i NN cord-346321-drhiqch0 88 18 P p NN cord-346321-drhiqch0 88 19 V v NN cord-346321-drhiqch0 88 20 infection infection NN cord-346321-drhiqch0 88 21 , , , cord-346321-drhiqch0 88 22 and and CC cord-346321-drhiqch0 88 23 suggested suggest VBD cord-346321-drhiqch0 88 24 that that IN cord-346321-drhiqch0 88 25 epitope epitope NN cord-346321-drhiqch0 88 26 of of IN cord-346321-drhiqch0 88 27 F f NN cord-346321-drhiqch0 88 28 I i NN cord-346321-drhiqch0 88 29 P p NN cord-346321-drhiqch0 88 30 V v NN cord-346321-drhiqch0 88 31 to to TO cord-346321-drhiqch0 88 32 be be VB cord-346321-drhiqch0 88 33 recognized recognize VBN cord-346321-drhiqch0 88 34 for for IN cord-346321-drhiqch0 88 35 A a DT cord-346321-drhiqch0 88 36 D d NN cord-346321-drhiqch0 88 37 E e NN cord-346321-drhiqch0 88 38 is be VBZ cord-346321-drhiqch0 88 39 closely closely RB cord-346321-drhiqch0 88 40 related related JJ cord-346321-drhiqch0 88 41 to to IN cord-346321-drhiqch0 88 42 that that DT cord-346321-drhiqch0 88 43 for for IN cord-346321-drhiqch0 88 44 virus virus NN cord-346321-drhiqch0 88 45 neutralization neutralization NN cord-346321-drhiqch0 88 46 [ [ -LRB- cord-346321-drhiqch0 88 47 5 5 CD cord-346321-drhiqch0 88 48 , , , cord-346321-drhiqch0 88 49 12 12 CD cord-346321-drhiqch0 88 50 , , , cord-346321-drhiqch0 88 51 13 13 CD cord-346321-drhiqch0 88 52 , , , cord-346321-drhiqch0 88 53 19 19 CD cord-346321-drhiqch0 88 54 , , , cord-346321-drhiqch0 88 55 20-I. 20-i. CD cord-346321-drhiqch0 89 1 In in IN cord-346321-drhiqch0 89 2 the the DT cord-346321-drhiqch0 89 3 present present JJ cord-346321-drhiqch0 89 4 study study NN cord-346321-drhiqch0 89 5 , , , cord-346321-drhiqch0 89 6 it -PRON- PRP cord-346321-drhiqch0 89 7 was be VBD cord-346321-drhiqch0 89 8 d d VBN cord-346321-drhiqch0 90 1 e e LS cord-346321-drhiqch0 90 2 m m NNP cord-346321-drhiqch0 91 1 o o UH cord-346321-drhiqch0 91 2 n n NN cord-346321-drhiqch0 91 3 s s NNP cord-346321-drhiqch0 92 1 t t NNP cord-346321-drhiqch0 92 2 r r NNP cord-346321-drhiqch0 93 1 a a DT cord-346321-drhiqch0 93 2 t t NN cord-346321-drhiqch0 93 3 e e NN cord-346321-drhiqch0 93 4 d d NN cord-346321-drhiqch0 93 5 that that WDT cord-346321-drhiqch0 93 6 even even RB cord-346321-drhiqch0 93 7 a a DT cord-346321-drhiqch0 93 8 m m NN cord-346321-drhiqch0 93 9 o o NN cord-346321-drhiqch0 93 10 n n NN cord-346321-drhiqch0 93 11 g g NN cord-346321-drhiqch0 93 12 mouse mouse NN cord-346321-drhiqch0 93 13 F f NN cord-346321-drhiqch0 93 14 I i NN cord-346321-drhiqch0 93 15 P p NN cord-346321-drhiqch0 93 16 V v NN cord-346321-drhiqch0 93 17 neutralizing neutralize VBG cord-346321-drhiqch0 93 18 MAbs MAbs NNP cord-346321-drhiqch0 93 19 that that WDT cord-346321-drhiqch0 93 20 have have VBP cord-346321-drhiqch0 93 21 been be VBN cord-346321-drhiqch0 93 22 shown show VBN cord-346321-drhiqch0 93 23 to to TO cord-346321-drhiqch0 93 24 recognize recognize VB cord-346321-drhiqch0 93 25 the the DT cord-346321-drhiqch0 93 26 same same JJ cord-346321-drhiqch0 93 27 antigenic antigenic JJ cord-346321-drhiqch0 93 28 site site NN cord-346321-drhiqch0 93 29 by by IN cord-346321-drhiqch0 93 30 competitive competitive JJ cord-346321-drhiqch0 93 31 binding binding NN cord-346321-drhiqch0 93 32 assay assay NN cord-346321-drhiqch0 93 33 , , , cord-346321-drhiqch0 93 34 IgG IgG NNP cord-346321-drhiqch0 93 35 2a 2a CD cord-346321-drhiqch0 94 1 M M NNP cord-346321-drhiqch0 94 2 A A NNP cord-346321-drhiqch0 94 3 b b NN cord-346321-drhiqch0 94 4 s s NN cord-346321-drhiqch0 95 1 but but CC cord-346321-drhiqch0 95 2 not not RB cord-346321-drhiqch0 95 3 IgG IgG NNP cord-346321-drhiqch0 95 4 1 1 CD cord-346321-drhiqch0 96 1 M M NNP cord-346321-drhiqch0 96 2 A A NNP cord-346321-drhiqch0 97 1 b b LS cord-346321-drhiqch0 97 2 s s NN cord-346321-drhiqch0 97 3 enhanced enhance VBD cord-346321-drhiqch0 97 4 F f NN cord-346321-drhiqch0 97 5 I i NN cord-346321-drhiqch0 97 6 P p NN cord-346321-drhiqch0 97 7 V v NN cord-346321-drhiqch0 97 8 infection infection NN cord-346321-drhiqch0 97 9 of of IN cord-346321-drhiqch0 97 10 feline feline JJ cord-346321-drhiqch0 97 11 alveolar alveolar NN cord-346321-drhiqch0 98 1 m m LS cord-346321-drhiqch0 98 2 a a DT cord-346321-drhiqch0 98 3 c c NN cord-346321-drhiqch0 98 4 r r NN cord-346321-drhiqch0 98 5 o o NN cord-346321-drhiqch0 98 6 p p NN cord-346321-drhiqch0 98 7 h h NN cord-346321-drhiqch0 98 8 a a NN cord-346321-drhiqch0 98 9 g g NN cord-346321-drhiqch0 98 10 e e NN cord-346321-drhiqch0 98 11 s s NN cord-346321-drhiqch0 98 12 ( ( -LRB- cord-346321-drhiqch0 98 13 Fig Fig NNP cord-346321-drhiqch0 98 14 . . NNP cord-346321-drhiqch0 98 15 1 1 CD cord-346321-drhiqch0 98 16 ) ) -RRB- cord-346321-drhiqch0 98 17 . . . cord-346321-drhiqch0 99 1 These these DT cord-346321-drhiqch0 99 2 IgG igg NN cord-346321-drhiqch0 99 3 2a 2a CD cord-346321-drhiqch0 99 4 MAbs MAbs NNP cord-346321-drhiqch0 99 5 enhanced enhance VBD cord-346321-drhiqch0 99 6 the the DT cord-346321-drhiqch0 99 7 infection infection NN cord-346321-drhiqch0 99 8 even even RB cord-346321-drhiqch0 99 9 when when WRB cord-346321-drhiqch0 99 10 macrophages macrophage NNS cord-346321-drhiqch0 99 11 pretreated pretreate VBN cord-346321-drhiqch0 99 12 with with IN cord-346321-drhiqch0 99 13 the the DT cord-346321-drhiqch0 99 14 MAb MAb NNS cord-346321-drhiqch0 99 15 were be VBD cord-346321-drhiqch0 99 16 washed wash VBN cord-346321-drhiqch0 99 17 and and CC cord-346321-drhiqch0 99 18 then then RB cord-346321-drhiqch0 99 19 inoculated inoculate VBD cord-346321-drhiqch0 99 20 with with IN cord-346321-drhiqch0 99 21 the the DT cord-346321-drhiqch0 99 22 virus virus NN cord-346321-drhiqch0 99 23 ( ( -LRB- cord-346321-drhiqch0 99 24 Fig Fig NNP cord-346321-drhiqch0 99 25 . . NNP cord-346321-drhiqch0 99 26 2 2 CD cord-346321-drhiqch0 99 27 ) ) -RRB- cord-346321-drhiqch0 99 28 . . . cord-346321-drhiqch0 100 1 Therefore therefore RB cord-346321-drhiqch0 100 2 we -PRON- PRP cord-346321-drhiqch0 100 3 assumed assume VBD cord-346321-drhiqch0 100 4 that that IN cord-346321-drhiqch0 100 5 mouse mouse NN cord-346321-drhiqch0 100 6 IgG IgG NNP cord-346321-drhiqch0 100 7 2a 2a CD cord-346321-drhiqch0 100 8 antibodies antibody NNS cord-346321-drhiqch0 100 9 can can MD cord-346321-drhiqch0 100 10 bind bind VB cord-346321-drhiqch0 100 11 Fc Fc NNP cord-346321-drhiqch0 100 12 ? ? . cord-346321-drhiqch0 101 1 R r NN cord-346321-drhiqch0 101 2 on on IN cord-346321-drhiqch0 101 3 feline feline JJ cord-346321-drhiqch0 101 4 alveolar alveolar NN cord-346321-drhiqch0 101 5 macrophages macrophage NNS cord-346321-drhiqch0 101 6 , , , cord-346321-drhiqch0 101 7 whereas whereas IN cord-346321-drhiqch0 101 8 IgG IgG NNP cord-346321-drhiqch0 101 9 1 1 CD cord-346321-drhiqch0 101 10 antibodies antibody NNS cord-346321-drhiqch0 101 11 can can MD cord-346321-drhiqch0 101 12 not not RB cord-346321-drhiqch0 101 13 . . . cord-346321-drhiqch0 102 1 This this DT cord-346321-drhiqch0 102 2 was be VBD cord-346321-drhiqch0 102 3 confirmed confirm VBN cord-346321-drhiqch0 102 4 by by IN cord-346321-drhiqch0 102 5 the the DT cord-346321-drhiqch0 102 6 flow flow NN cord-346321-drhiqch0 102 7 cytometric cytometric NNP cord-346321-drhiqch0 102 8 analysis analysis NN cord-346321-drhiqch0 102 9 of of IN cord-346321-drhiqch0 102 10 binding bind VBG cord-346321-drhiqch0 102 11 of of IN cord-346321-drhiqch0 102 12 the the DT cord-346321-drhiqch0 102 13 MAbs MAbs NNP cord-346321-drhiqch0 102 14 to to IN cord-346321-drhiqch0 102 15 feline feline JJ cord-346321-drhiqch0 102 16 macrophages macrophage NNS cord-346321-drhiqch0 102 17 ( ( -LRB- cord-346321-drhiqch0 102 18 Fig Fig NNP cord-346321-drhiqch0 102 19 . . . cord-346321-drhiqch0 102 20 3 3 CD cord-346321-drhiqch0 102 21 ) ) -RRB- cord-346321-drhiqch0 102 22 . . . cord-346321-drhiqch0 103 1 In in IN cord-346321-drhiqch0 103 2 addition addition NN cord-346321-drhiqch0 103 3 , , , cord-346321-drhiqch0 103 4 it -PRON- PRP cord-346321-drhiqch0 103 5 was be VBD cord-346321-drhiqch0 103 6 found find VBN cord-346321-drhiqch0 103 7 that that IN cord-346321-drhiqch0 103 8 the the DT cord-346321-drhiqch0 103 9 IgG IgG NNP cord-346321-drhiqch0 103 10 2a 2a NNP cord-346321-drhiqch0 103 11 MAbs MAbs NNP cord-346321-drhiqch0 103 12 complexed complexe VBN cord-346321-drhiqch0 103 13 with with IN cord-346321-drhiqch0 103 14 FIPV FIPV NNS cord-346321-drhiqch0 103 15 bound bind VBN cord-346321-drhiqch0 103 16 to to IN cord-346321-drhiqch0 103 17 macrophages macrophage NNS cord-346321-drhiqch0 103 18 more more RBR cord-346321-drhiqch0 103 19 intensely intensely RB cord-346321-drhiqch0 103 20 than than IN cord-346321-drhiqch0 103 21 the the DT cord-346321-drhiqch0 103 22 MAb MAb NNS cord-346321-drhiqch0 103 23 alone alone RB cord-346321-drhiqch0 103 24 did do VBD cord-346321-drhiqch0 103 25 ( ( -LRB- cord-346321-drhiqch0 103 26 Figs fig NNS cord-346321-drhiqch0 103 27 . . . cord-346321-drhiqch0 104 1 3A 3A NNP cord-346321-drhiqch0 104 2 and and CC cord-346321-drhiqch0 104 3 B B NNP cord-346321-drhiqch0 104 4 ) ) -RRB- cord-346321-drhiqch0 104 5 . . . cord-346321-drhiqch0 105 1 In in IN cord-346321-drhiqch0 105 2 accordance accordance NN cord-346321-drhiqch0 105 3 with with IN cord-346321-drhiqch0 105 4 these these DT cord-346321-drhiqch0 105 5 findings finding NNS cord-346321-drhiqch0 105 6 , , , cord-346321-drhiqch0 105 7 ADE ADE NNP cord-346321-drhiqch0 105 8 of of IN cord-346321-drhiqch0 105 9 the the DT cord-346321-drhiqch0 105 10 FIPV FIPV NNS cord-346321-drhiqch0 105 11 infection infection NN cord-346321-drhiqch0 105 12 was be VBD cord-346321-drhiqch0 105 13 intenser intense JJR cord-346321-drhiqch0 105 14 in in IN cord-346321-drhiqch0 105 15 the the DT cord-346321-drhiqch0 105 16 macrophages macrophage NNS cord-346321-drhiqch0 105 17 infected infect VBN cord-346321-drhiqch0 105 18 by by IN cord-346321-drhiqch0 105 19 the the DT cord-346321-drhiqch0 105 20 former former JJ cord-346321-drhiqch0 105 21 pathway pathway NN cord-346321-drhiqch0 105 22 than than IN cord-346321-drhiqch0 105 23 in in IN cord-346321-drhiqch0 105 24 the the DT cord-346321-drhiqch0 105 25 virus virus NN cord-346321-drhiqch0 105 26 - - HYPH cord-346321-drhiqch0 105 27 inoculated inoculate VBN cord-346321-drhiqch0 105 28 latter latter JJ cord-346321-drhiqch0 105 29 macrophages macrophage NNS cord-346321-drhiqch0 105 30 ( ( -LRB- cord-346321-drhiqch0 105 31 Figs fig NNS cord-346321-drhiqch0 105 32 . . . cord-346321-drhiqch0 105 33 1 1 CD cord-346321-drhiqch0 105 34 and and CC cord-346321-drhiqch0 105 35 2 2 CD cord-346321-drhiqch0 105 36 ) ) -RRB- cord-346321-drhiqch0 105 37 . . . cord-346321-drhiqch0 106 1 Flow flow VB cord-346321-drhiqch0 106 2 cytometric cytometric NN cord-346321-drhiqch0 106 3 analysis analysis NN cord-346321-drhiqch0 106 4 of of IN cord-346321-drhiqch0 106 5 the the DT cord-346321-drhiqch0 106 6 binding binding NN cord-346321-drhiqch0 106 7 of of IN cord-346321-drhiqch0 106 8 protein protein NN cord-346321-drhiqch0 106 9 A A NNP cord-346321-drhiqch0 106 10 - - HYPH cord-346321-drhiqch0 106 11 treated treat VBN cord-346321-drhiqch0 106 12 IgG igg NN cord-346321-drhiqch0 106 13 2a 2a CD cord-346321-drhiqch0 106 14 MAb MAb NNS cord-346321-drhiqch0 106 15 to to IN cord-346321-drhiqch0 106 16 macrophages macrophage NNS cord-346321-drhiqch0 106 17 and and CC cord-346321-drhiqch0 106 18 determination determination NN cord-346321-drhiqch0 106 19 of of IN cord-346321-drhiqch0 106 20 ADE ADE NNP cord-346321-drhiqch0 106 21 of of IN cord-346321-drhiqch0 106 22 FIPV FIPV NNS cord-346321-drhiqch0 106 23 infection infection NN cord-346321-drhiqch0 106 24 by by IN cord-346321-drhiqch0 106 25 the the DT cord-346321-drhiqch0 106 26 treated treat VBN cord-346321-drhiqch0 106 27 MAb MAb NNS cord-346321-drhiqch0 106 28 revealed reveal VBD cord-346321-drhiqch0 106 29 that that IN cord-346321-drhiqch0 106 30 the the DT cord-346321-drhiqch0 106 31 binding binding NN cord-346321-drhiqch0 106 32 of of IN cord-346321-drhiqch0 106 33 the the DT cord-346321-drhiqch0 106 34 mouse mouse NN cord-346321-drhiqch0 106 35 IgG IgG NNP cord-346321-drhiqch0 106 36 2a 2a NNP cord-346321-drhiqch0 106 37 MAbs MAbs NNP cord-346321-drhiqch0 106 38 to to IN cord-346321-drhiqch0 106 39 feline feline JJ cord-346321-drhiqch0 106 40 macrophages macrophage NNS cord-346321-drhiqch0 106 41 and and CC cord-346321-drhiqch0 106 42 their -PRON- PRP$ cord-346321-drhiqch0 106 43 ADE ade NN cord-346321-drhiqch0 106 44 activity activity NN cord-346321-drhiqch0 106 45 on on IN cord-346321-drhiqch0 106 46 FIPV FIPV NNS cord-346321-drhiqch0 106 47 infection infection NN cord-346321-drhiqch0 106 48 of of IN cord-346321-drhiqch0 106 49 the the DT cord-346321-drhiqch0 106 50 macrophages macrophage NNS cord-346321-drhiqch0 106 51 are be VBP cord-346321-drhiqch0 106 52 mediated mediate VBN cord-346321-drhiqch0 106 53 by by IN cord-346321-drhiqch0 106 54 Fc Fc NNP cord-346321-drhiqch0 106 55 region region NN cord-346321-drhiqch0 106 56 of of IN cord-346321-drhiqch0 106 57 the the DT cord-346321-drhiqch0 106 58 MAbs MAbs NNP cord-346321-drhiqch0 107 1 ( ( -LRB- cord-346321-drhiqch0 107 2 Fig Fig NNP cord-346321-drhiqch0 107 3 . . NNP cord-346321-drhiqch0 107 4 4 4 CD cord-346321-drhiqch0 107 5 ) ) -RRB- cord-346321-drhiqch0 107 6 . . . cord-346321-drhiqch0 108 1 Since since IN cord-346321-drhiqch0 108 2 Fc Fc NNP cord-346321-drhiqch0 108 3 y y NNP cord-346321-drhiqch0 108 4 Rs r NNS cord-346321-drhiqch0 108 5 on on IN cord-346321-drhiqch0 108 6 feline feline JJ cord-346321-drhiqch0 108 7 cells cell NNS cord-346321-drhiqch0 108 8 have have VBP cord-346321-drhiqch0 108 9 not not RB cord-346321-drhiqch0 108 10 been be VBN cord-346321-drhiqch0 108 11 defined define VBN cord-346321-drhiqch0 108 12 , , , cord-346321-drhiqch0 108 13 we -PRON- PRP cord-346321-drhiqch0 108 14 explored explore VBD cord-346321-drhiqch0 108 15 the the DT cord-346321-drhiqch0 108 16 Fc Fc NNP cord-346321-drhiqch0 108 17 - - HYPH cord-346321-drhiqch0 108 18 mediated mediate VBN cord-346321-drhiqch0 108 19 ADE ade NN cord-346321-drhiqch0 108 20 of of IN cord-346321-drhiqch0 108 21 FIPV FIPV NNS cord-346321-drhiqch0 108 22 infection infection NN cord-346321-drhiqch0 108 23 by by IN cord-346321-drhiqch0 108 24 using use VBG cord-346321-drhiqch0 108 25 human human JJ cord-346321-drhiqch0 108 26 cells cell NNS cord-346321-drhiqch0 108 27 , , , cord-346321-drhiqch0 108 28 of of IN cord-346321-drhiqch0 108 29 which which WDT cord-346321-drhiqch0 108 30 Fc Fc NNP cord-346321-drhiqch0 108 31 y y NNP cord-346321-drhiqch0 108 32 Rs r NNS cord-346321-drhiqch0 108 33 are be VBP cord-346321-drhiqch0 108 34 well well RB cord-346321-drhiqch0 108 35 defined define VBN cord-346321-drhiqch0 108 36 , , , cord-346321-drhiqch0 108 37 as as IN cord-346321-drhiqch0 108 38 targets target NNS cord-346321-drhiqch0 108 39 of of IN cord-346321-drhiqch0 108 40 the the DT cord-346321-drhiqch0 108 41 virus virus NN cord-346321-drhiqch0 108 42 . . . cord-346321-drhiqch0 109 1 It -PRON- PRP cord-346321-drhiqch0 109 2 is be VBZ cord-346321-drhiqch0 109 3 known know VBN cord-346321-drhiqch0 109 4 that that IN cord-346321-drhiqch0 109 5 there there EX cord-346321-drhiqch0 109 6 are be VBP cord-346321-drhiqch0 109 7 three three CD cord-346321-drhiqch0 109 8 types type NNS cord-346321-drhiqch0 109 9 of of IN cord-346321-drhiqch0 109 10 human human JJ cord-346321-drhiqch0 109 11 Fc Fc NNP cord-346321-drhiqch0 109 12 y y NNP cord-346321-drhiqch0 109 13 R r NN cord-346321-drhiqch0 109 14 , , , cord-346321-drhiqch0 109 15 i.e. i.e. FW cord-346321-drhiqch0 109 16 , , , cord-346321-drhiqch0 109 17 Fc Fc NNP cord-346321-drhiqch0 109 18 y y NNP cord-346321-drhiqch0 109 19 R r NN cord-346321-drhiqch0 109 20 I i NN cord-346321-drhiqch0 109 21 , , , cord-346321-drhiqch0 109 22 II II NNP cord-346321-drhiqch0 109 23 and and CC cord-346321-drhiqch0 109 24 III III NNP cord-346321-drhiqch0 109 25 [ [ -LRB- cord-346321-drhiqch0 109 26 32 32 CD cord-346321-drhiqch0 109 27 ] ] -RRB- cord-346321-drhiqch0 109 28 . . . cord-346321-drhiqch0 110 1 It -PRON- PRP cord-346321-drhiqch0 110 2 has have VBZ cord-346321-drhiqch0 110 3 also also RB cord-346321-drhiqch0 110 4 been be VBN cord-346321-drhiqch0 110 5 shown show VBN cord-346321-drhiqch0 110 6 that that IN cord-346321-drhiqch0 110 7 Fc Fc NNP cord-346321-drhiqch0 110 8 7 7 CD cord-346321-drhiqch0 110 9 R R NNP cord-346321-drhiqch0 110 10 I i NN cord-346321-drhiqch0 110 11 and and CC cord-346321-drhiqch0 110 12 II II NNP cord-346321-drhiqch0 110 13 are be VBP cord-346321-drhiqch0 110 14 present present JJ cord-346321-drhiqch0 110 15 on on IN cord-346321-drhiqch0 110 16 human human JJ cord-346321-drhiqch0 110 17 macrophages macrophage NNS cord-346321-drhiqch0 110 18 and and CC cord-346321-drhiqch0 110 19 that that IN cord-346321-drhiqch0 110 20 mouse mouse NNP cord-346321-drhiqch0 110 21 IgG IgG NNP cord-346321-drhiqch0 110 22 2a 2a NNP cord-346321-drhiqch0 110 23 and and CC cord-346321-drhiqch0 110 24 IgG IgG NNP cord-346321-drhiqch0 110 25 1 1 CD cord-346321-drhiqch0 110 26 bind bind VBP cord-346321-drhiqch0 110 27 well well RB cord-346321-drhiqch0 110 28 to to IN cord-346321-drhiqch0 110 29 the the DT cord-346321-drhiqch0 110 30 Fc Fc NNP cord-346321-drhiqch0 110 31 ? ? . cord-346321-drhiqch0 111 1 R R NNP cord-346321-drhiqch0 111 2 I i NN cord-346321-drhiqch0 111 3 and and CC cord-346321-drhiqch0 111 4 II II NNP cord-346321-drhiqch0 111 5 , , , cord-346321-drhiqch0 111 6 respectively respectively RB cord-346321-drhiqch0 111 7 . . . cord-346321-drhiqch0 112 1 The the DT cord-346321-drhiqch0 112 2 human human JJ cord-346321-drhiqch0 112 3 monocyte monocyte NNP cord-346321-drhiqch0 112 4 cell cell NN cord-346321-drhiqch0 112 5 line line NN cord-346321-drhiqch0 112 6 U937 U937 NNP cord-346321-drhiqch0 112 7 cells cell NNS cord-346321-drhiqch0 112 8 used use VBN cord-346321-drhiqch0 112 9 in in IN cord-346321-drhiqch0 112 10 the the DT cord-346321-drhiqch0 112 11 present present JJ cord-346321-drhiqch0 112 12 study study NN cord-346321-drhiqch0 112 13 were be VBD cord-346321-drhiqch0 112 14 shown show VBN cord-346321-drhiqch0 112 15 to to TO cord-346321-drhiqch0 112 16 express express VB cord-346321-drhiqch0 112 17 Fc Fc NNP cord-346321-drhiqch0 112 18 7 7 CD cord-346321-drhiqch0 112 19 R R NNP cord-346321-drhiqch0 112 20 I i NN cord-346321-drhiqch0 112 21 and and CC cord-346321-drhiqch0 112 22 II II NNP cord-346321-drhiqch0 112 23 to to IN cord-346321-drhiqch0 112 24 a a DT cord-346321-drhiqch0 112 25 similar similar JJ cord-346321-drhiqch0 112 26 degree degree NN cord-346321-drhiqch0 112 27 on on IN cord-346321-drhiqch0 112 28 their -PRON- PRP$ cord-346321-drhiqch0 112 29 surface surface NN cord-346321-drhiqch0 112 30 from from IN cord-346321-drhiqch0 112 31 the the DT cord-346321-drhiqch0 112 32 reactivity reactivity NN cord-346321-drhiqch0 112 33 to to IN cord-346321-drhiqch0 112 34 MAb MAb NNS cord-346321-drhiqch0 112 35 specific specific JJ cord-346321-drhiqch0 112 36 to to IN cord-346321-drhiqch0 112 37 the the DT cord-346321-drhiqch0 112 38 respective respective JJ cord-346321-drhiqch0 112 39 human human JJ cord-346321-drhiqch0 112 40 Fc Fc NNP cord-346321-drhiqch0 112 41 y y NNP cord-346321-drhiqch0 112 42 R r NN cord-346321-drhiqch0 112 43 ( ( -LRB- cord-346321-drhiqch0 112 44 Fig Fig NNP cord-346321-drhiqch0 112 45 . . . cord-346321-drhiqch0 112 46 5 5 CD cord-346321-drhiqch0 112 47 ) ) -RRB- cord-346321-drhiqch0 112 48 . . . cord-346321-drhiqch0 113 1 FIPV FIPV NNS cord-346321-drhiqch0 113 2 strain strain VBP cord-346321-drhiqch0 113 3 79 79 CD cord-346321-drhiqch0 113 4 - - SYM cord-346321-drhiqch0 113 5 1146 1146 CD cord-346321-drhiqch0 113 6 did do VBD cord-346321-drhiqch0 113 7 not not RB cord-346321-drhiqch0 113 8 infect infect VB cord-346321-drhiqch0 113 9 U937 U937 NNP cord-346321-drhiqch0 113 10 cells cell NNS cord-346321-drhiqch0 113 11 at at RB cord-346321-drhiqch0 113 12 all all RB cord-346321-drhiqch0 113 13 . . . cord-346321-drhiqch0 114 1 However however RB cord-346321-drhiqch0 114 2 , , , cord-346321-drhiqch0 114 3 when when WRB cord-346321-drhiqch0 114 4 the the DT cord-346321-drhiqch0 114 5 FIPV FIPV NNS cord-346321-drhiqch0 114 6 complexed complexe VBN cord-346321-drhiqch0 114 7 with with IN cord-346321-drhiqch0 114 8 either either DT cord-346321-drhiqch0 114 9 one one CD cord-346321-drhiqch0 114 10 of of IN cord-346321-drhiqch0 114 11 the the DT cord-346321-drhiqch0 114 12 mouse mouse NN cord-346321-drhiqch0 114 13 anti anti NNP cord-346321-drhiqch0 114 14 - - NNP cord-346321-drhiqch0 114 15 FIPV FIPV NNP cord-346321-drhiqch0 114 16 MAbs MAbs NNP cord-346321-drhiqch0 114 17 was be VBD cord-346321-drhiqch0 114 18 inoculated inoculate VBN cord-346321-drhiqch0 114 19 onto onto IN cord-346321-drhiqch0 114 20 U937 U937 NNP cord-346321-drhiqch0 114 21 cells cell NNS cord-346321-drhiqch0 114 22 , , , cord-346321-drhiqch0 114 23 distinct distinct JJ cord-346321-drhiqch0 114 24 viral viral JJ cord-346321-drhiqch0 114 25 proliferation proliferation NN cord-346321-drhiqch0 114 26 was be VBD cord-346321-drhiqch0 114 27 observed observe VBN cord-346321-drhiqch0 114 28 . . . cord-346321-drhiqch0 115 1 Notably notably RB cord-346321-drhiqch0 115 2 , , , cord-346321-drhiqch0 115 3 IgG IgG NNP cord-346321-drhiqch0 115 4 1 1 CD cord-346321-drhiqch0 115 5 MAbs MAbs NNP cord-346321-drhiqch0 115 6 , , , cord-346321-drhiqch0 115 7 which which WDT cord-346321-drhiqch0 115 8 did do VBD cord-346321-drhiqch0 115 9 not not RB cord-346321-drhiqch0 115 10 bind bind VB cord-346321-drhiqch0 115 11 to to IN cord-346321-drhiqch0 115 12 feline feline JJ cord-346321-drhiqch0 115 13 macrophages macrophage NNS cord-346321-drhiqch0 115 14 and and CC cord-346321-drhiqch0 115 15 did do VBD cord-346321-drhiqch0 115 16 not not RB cord-346321-drhiqch0 115 17 cause cause VB cord-346321-drhiqch0 115 18 ADE ADE NNP cord-346321-drhiqch0 115 19 of of IN cord-346321-drhiqch0 115 20 FIPV FIPV NNS cord-346321-drhiqch0 115 21 infection infection NN cord-346321-drhiqch0 115 22 of of IN cord-346321-drhiqch0 115 23 feline feline JJ cord-346321-drhiqch0 115 24 macrophages macrophage NNS cord-346321-drhiqch0 115 25 , , , cord-346321-drhiqch0 115 26 caused cause VBD cord-346321-drhiqch0 115 27 viral viral JJ cord-346321-drhiqch0 115 28 proliferation proliferation NN cord-346321-drhiqch0 115 29 in in IN cord-346321-drhiqch0 115 30 U937 u937 CD cord-346321-drhiqch0 115 31 cells cell NNS cord-346321-drhiqch0 115 32 . . . cord-346321-drhiqch0 116 1 These these DT cord-346321-drhiqch0 116 2 results result NNS cord-346321-drhiqch0 116 3 suggest suggest VBP cord-346321-drhiqch0 116 4 that that IN cord-346321-drhiqch0 116 5 U937 U937 NNP cord-346321-drhiqch0 116 6 cells cell NNS cord-346321-drhiqch0 116 7 of of IN cord-346321-drhiqch0 116 8 human human JJ cord-346321-drhiqch0 116 9 origin origin NN cord-346321-drhiqch0 116 10 have have VBP cord-346321-drhiqch0 116 11 no no DT cord-346321-drhiqch0 116 12 virus virus NN cord-346321-drhiqch0 116 13 receptor receptor NN cord-346321-drhiqch0 116 14 for for IN cord-346321-drhiqch0 116 15 FIPV FIPV NNS cord-346321-drhiqch0 116 16 , , , cord-346321-drhiqch0 116 17 but but CC cord-346321-drhiqch0 116 18 Fc Fc NNP cord-346321-drhiqch0 116 19 ? ? . cord-346321-drhiqch0 117 1 Rs r NNS cord-346321-drhiqch0 117 2 , , , cord-346321-drhiqch0 117 3 i.e. i.e. FW cord-346321-drhiqch0 117 4 , , , cord-346321-drhiqch0 117 5 Fc Fc NNP cord-346321-drhiqch0 117 6 y y NN cord-346321-drhiqch0 117 7 R r NN cord-346321-drhiqch0 117 8 I i NN cord-346321-drhiqch0 117 9 and and CC cord-346321-drhiqch0 117 10 II II NNP cord-346321-drhiqch0 117 11 , , , cord-346321-drhiqch0 117 12 act act VBP cord-346321-drhiqch0 117 13 as as IN cord-346321-drhiqch0 117 14 receptors receptor NNS cord-346321-drhiqch0 117 15 for for IN cord-346321-drhiqch0 117 16 the the DT cord-346321-drhiqch0 117 17 mouse mouse NN cord-346321-drhiqch0 117 18 IgG IgG NNP cord-346321-drhiqch0 117 19 2a 2a NNP cord-346321-drhiqch0 117 20 and and CC cord-346321-drhiqch0 117 21 IgG IgG NNP cord-346321-drhiqch0 117 22 1 1 CD cord-346321-drhiqch0 117 23 MAbs MAbs NNP cord-346321-drhiqch0 118 1 complexed complexe VBN cord-346321-drhiqch0 118 2 with with IN cord-346321-drhiqch0 118 3 the the DT cord-346321-drhiqch0 118 4 virus virus NN cord-346321-drhiqch0 118 5 and and CC cord-346321-drhiqch0 118 6 thus thus RB cord-346321-drhiqch0 118 7 allow allow VB cord-346321-drhiqch0 118 8 the the DT cord-346321-drhiqch0 118 9 virus virus NN cord-346321-drhiqch0 118 10 to to TO cord-346321-drhiqch0 118 11 enter enter VB cord-346321-drhiqch0 118 12 and and CC cord-346321-drhiqch0 118 13 proliferate proliferate VB cord-346321-drhiqch0 118 14 in in IN cord-346321-drhiqch0 118 15 the the DT cord-346321-drhiqch0 118 16 cells cell NNS cord-346321-drhiqch0 118 17 . . . cord-346321-drhiqch0 119 1 Some some DT cord-346321-drhiqch0 119 2 mouse mouse NN cord-346321-drhiqch0 119 3 anti anti NNP cord-346321-drhiqch0 119 4 - - NNP cord-346321-drhiqch0 119 5 FIPV FIPV NNP cord-346321-drhiqch0 119 6 IgG igg NN cord-346321-drhiqch0 119 7 1 1 CD cord-346321-drhiqch0 119 8 MAbs MAbs NNP cord-346321-drhiqch0 119 9 devoid devoid JJ cord-346321-drhiqch0 119 10 of of IN cord-346321-drhiqch0 119 11 neutralizing neutralize VBG cord-346321-drhiqch0 119 12 activity activity NN cord-346321-drhiqch0 119 13 were be VBD cord-346321-drhiqch0 119 14 reported report VBN cord-346321-drhiqch0 119 15 to to TO cord-346321-drhiqch0 119 16 exert exert VB cord-346321-drhiqch0 119 17 ADE ADE NNP cord-346321-drhiqch0 119 18 of of IN cord-346321-drhiqch0 119 19 FIPV FIPV NNS cord-346321-drhiqch0 119 20 infection infection NN cord-346321-drhiqch0 119 21 of of IN cord-346321-drhiqch0 119 22 feline feline JJ cord-346321-drhiqch0 119 23 macrophages macrophage NNS cord-346321-drhiqch0 119 24 [ [ -LRB- cord-346321-drhiqch0 119 25 5 5 CD cord-346321-drhiqch0 119 26 , , , cord-346321-drhiqch0 119 27 20 20 CD cord-346321-drhiqch0 119 28 ] ] -RRB- cord-346321-drhiqch0 119 29 , , , cord-346321-drhiqch0 119 30 though though IN cord-346321-drhiqch0 119 31 the the DT cord-346321-drhiqch0 119 32 ADE ADE NNP cord-346321-drhiqch0 119 33 activity activity NN cord-346321-drhiqch0 119 34 of of IN cord-346321-drhiqch0 119 35 these these DT cord-346321-drhiqch0 119 36 IgG igg NN cord-346321-drhiqch0 119 37 1 1 CD cord-346321-drhiqch0 119 38 MAbs MAbs NNP cord-346321-drhiqch0 119 39 was be VBD cord-346321-drhiqch0 119 40 far far RB cord-346321-drhiqch0 119 41 less less JJR cord-346321-drhiqch0 119 42 than than IN cord-346321-drhiqch0 119 43 that that DT cord-346321-drhiqch0 119 44 of of IN cord-346321-drhiqch0 119 45 mouse mouse NNP cord-346321-drhiqch0 119 46 IgG IgG NNP cord-346321-drhiqch0 119 47 2a 2a NNP cord-346321-drhiqch0 119 48 MAbs MAbs NNP cord-346321-drhiqch0 119 49 used use VBN cord-346321-drhiqch0 119 50 in in IN cord-346321-drhiqch0 119 51 the the DT cord-346321-drhiqch0 119 52 present present JJ cord-346321-drhiqch0 119 53 study study NN cord-346321-drhiqch0 119 54 . . . cord-346321-drhiqch0 120 1 Reason reason NN cord-346321-drhiqch0 120 2 for for IN cord-346321-drhiqch0 120 3 the the DT cord-346321-drhiqch0 120 4 discrepancy discrepancy NN cord-346321-drhiqch0 120 5 between between IN cord-346321-drhiqch0 120 6 these these DT cord-346321-drhiqch0 120 7 studies study NNS cord-346321-drhiqch0 120 8 and and CC cord-346321-drhiqch0 120 9 our -PRON- PRP$ cord-346321-drhiqch0 120 10 study study NN cord-346321-drhiqch0 120 11 , , , cord-346321-drhiqch0 120 12 in in IN cord-346321-drhiqch0 120 13 which which WDT cord-346321-drhiqch0 120 14 mouse mouse NN cord-346321-drhiqch0 120 15 anti anti NNP cord-346321-drhiqch0 120 16 - - NNP cord-346321-drhiqch0 120 17 FIPV FIPV NNP cord-346321-drhiqch0 120 18 IgG igg NN cord-346321-drhiqch0 120 19 1 1 CD cord-346321-drhiqch0 120 20 MAbs MAbs NNP cord-346321-drhiqch0 120 21 were be VBD cord-346321-drhiqch0 120 22 not not RB cord-346321-drhiqch0 120 23 found find VBN cord-346321-drhiqch0 120 24 to to TO cord-346321-drhiqch0 120 25 show show VB cord-346321-drhiqch0 120 26 ADE ADE NNP cord-346321-drhiqch0 120 27 of of IN cord-346321-drhiqch0 120 28 FIPV FIPV NNS cord-346321-drhiqch0 120 29 infection infection NN cord-346321-drhiqch0 120 30 of of IN cord-346321-drhiqch0 120 31 feline feline JJ cord-346321-drhiqch0 120 32 macrophages macrophage NNS cord-346321-drhiqch0 120 33 , , , cord-346321-drhiqch0 120 34 is be VBZ cord-346321-drhiqch0 120 35 not not RB cord-346321-drhiqch0 120 36 clear clear JJ cord-346321-drhiqch0 120 37 . . . cord-346321-drhiqch0 121 1 There there EX cord-346321-drhiqch0 121 2 are be VBP cord-346321-drhiqch0 121 3 the the DT cord-346321-drhiqch0 121 4 following follow VBG cord-346321-drhiqch0 121 5 possibilities possibility NNS cord-346321-drhiqch0 121 6 : : : cord-346321-drhiqch0 121 7 Fc Fc NNP cord-346321-drhiqch0 121 8 y y NNP cord-346321-drhiqch0 121 9 R r NN cord-346321-drhiqch0 121 10 for for IN cord-346321-drhiqch0 121 11 mouse mouse NN cord-346321-drhiqch0 121 12 IgG IgG NNP cord-346321-drhiqch0 121 13 1 1 CD cord-346321-drhiqch0 121 14 is be VBZ cord-346321-drhiqch0 121 15 expressed express VBN cord-346321-drhiqch0 121 16 on on IN cord-346321-drhiqch0 121 17 feline feline JJ cord-346321-drhiqch0 121 18 macrophages macrophage NNS cord-346321-drhiqch0 121 19 in in IN cord-346321-drhiqch0 121 20 very very RB cord-346321-drhiqch0 121 21 small small JJ cord-346321-drhiqch0 121 22 number number NN cord-346321-drhiqch0 121 23 , , , cord-346321-drhiqch0 121 24 or or CC cord-346321-drhiqch0 121 25 Fc Fc NNP cord-346321-drhiqch0 121 26 y y NNP cord-346321-drhiqch0 121 27 R r NN cord-346321-drhiqch0 121 28 for for IN cord-346321-drhiqch0 121 29 mouse mouse NN cord-346321-drhiqch0 121 30 IgG IgG NNP cord-346321-drhiqch0 121 31 1 1 CD cord-346321-drhiqch0 121 32 on on IN cord-346321-drhiqch0 121 33 feline feline JJ cord-346321-drhiqch0 121 34 macrophages macrophage NNS cord-346321-drhiqch0 121 35 has have VBZ cord-346321-drhiqch0 121 36 very very RB cord-346321-drhiqch0 121 37 low low JJ cord-346321-drhiqch0 121 38 affinity affinity NN cord-346321-drhiqch0 121 39 . . . cord-346321-drhiqch0 122 1 In in IN cord-346321-drhiqch0 122 2 relation relation NN cord-346321-drhiqch0 122 3 to to IN cord-346321-drhiqch0 122 4 the the DT cord-346321-drhiqch0 122 5 latter latter JJ cord-346321-drhiqch0 122 6 possibility possibility NN cord-346321-drhiqch0 122 7 , , , cord-346321-drhiqch0 122 8 U937 u937 CD cord-346321-drhiqch0 122 9 cells cell NNS cord-346321-drhiqch0 122 10 of of IN cord-346321-drhiqch0 122 11 human human JJ cord-346321-drhiqch0 122 12 origin origin NN cord-346321-drhiqch0 122 13 express express NNP cord-346321-drhiqch0 122 14 Fc Fc NNP cord-346321-drhiqch0 122 15 y y NNP cord-346321-drhiqch0 122 16 R r NN cord-346321-drhiqch0 122 17 I i NN cord-346321-drhiqch0 122 18 and and CC cord-346321-drhiqch0 122 19 II II NNP cord-346321-drhiqch0 122 20 at at IN cord-346321-drhiqch0 122 21 a a DT cord-346321-drhiqch0 122 22 similar similar JJ cord-346321-drhiqch0 122 23 level level NN cord-346321-drhiqch0 122 24 , , , cord-346321-drhiqch0 122 25 but but CC cord-346321-drhiqch0 122 26 ADE ADE NNP cord-346321-drhiqch0 122 27 activity activity NN cord-346321-drhiqch0 122 28 of of IN cord-346321-drhiqch0 122 29 mouse mouse NN cord-346321-drhiqch0 122 30 anti anti NNP cord-346321-drhiqch0 122 31 - - NNP cord-346321-drhiqch0 122 32 FIPV FIPV NNP cord-346321-drhiqch0 122 33 IgG igg NN cord-346321-drhiqch0 122 34 1 1 CD cord-346321-drhiqch0 122 35 MAb MAb NNS cord-346321-drhiqch0 122 36 on on IN cord-346321-drhiqch0 122 37 FIPV FIPV NNS cord-346321-drhiqch0 122 38 infection infection NN cord-346321-drhiqch0 122 39 of of IN cord-346321-drhiqch0 122 40 these these DT cord-346321-drhiqch0 122 41 cells cell NNS cord-346321-drhiqch0 122 42 was be VBD cord-346321-drhiqch0 122 43 found find VBN cord-346321-drhiqch0 122 44 to to TO cord-346321-drhiqch0 122 45 be be VB cord-346321-drhiqch0 122 46 far far RB cord-346321-drhiqch0 122 47 weaker weak JJR cord-346321-drhiqch0 122 48 than than IN cord-346321-drhiqch0 122 49 that that DT cord-346321-drhiqch0 122 50 of of IN cord-346321-drhiqch0 122 51 anti anti JJ cord-346321-drhiqch0 122 52 - - JJ cord-346321-drhiqch0 122 53 FIPV FIPV NNP cord-346321-drhiqch0 122 54 IgG igg NN cord-346321-drhiqch0 122 55 2a 2a CD cord-346321-drhiqch0 122 56 MAb MAb NNS cord-346321-drhiqch0 122 57 . . . cord-346321-drhiqch0 123 1 It -PRON- PRP cord-346321-drhiqch0 123 2 is be VBZ cord-346321-drhiqch0 123 3 also also RB cord-346321-drhiqch0 123 4 known know VBN cord-346321-drhiqch0 123 5 that that IN cord-346321-drhiqch0 123 6 human human JJ cord-346321-drhiqch0 123 7 IgG IgG NNP cord-346321-drhiqch0 123 8 2 2 CD cord-346321-drhiqch0 123 9 and and CC cord-346321-drhiqch0 123 10 IgG IgG NNP cord-346321-drhiqch0 123 11 4 4 CD cord-346321-drhiqch0 123 12 have have VBP cord-346321-drhiqch0 123 13 weak weak JJ cord-346321-drhiqch0 123 14 affinity affinity NN cord-346321-drhiqch0 123 15 for for IN cord-346321-drhiqch0 123 16 Fc Fc NNP cord-346321-drhiqch0 123 17 y y NNP cord-346321-drhiqch0 123 18 R r NN cord-346321-drhiqch0 123 19 on on IN cord-346321-drhiqch0 123 20 human human JJ cord-346321-drhiqch0 123 21 macrophages macrophage NNS cord-346321-drhiqch0 123 22 [ [ -LRB- cord-346321-drhiqch0 123 23 32 32 CD cord-346321-drhiqch0 123 24 ] ] -RRB- cord-346321-drhiqch0 123 25 . . . cord-346321-drhiqch0 124 1 One one CD cord-346321-drhiqch0 124 2 study study NN cord-346321-drhiqch0 124 3 of of IN cord-346321-drhiqch0 124 4 ADE ADE NNP cord-346321-drhiqch0 124 5 of of IN cord-346321-drhiqch0 124 6 dengue dengue NN cord-346321-drhiqch0 124 7 virus virus NN cord-346321-drhiqch0 124 8 infection infection NN cord-346321-drhiqch0 124 9 of of IN cord-346321-drhiqch0 124 10 mouse mouse NN cord-346321-drhiqch0 124 11 macrophages macrophage NNS cord-346321-drhiqch0 124 12 has have VBZ cord-346321-drhiqch0 124 13 shown show VBN cord-346321-drhiqch0 124 14 that that DT cord-346321-drhiqch0 124 15 treatment treatment NN cord-346321-drhiqch0 124 16 of of IN cord-346321-drhiqch0 124 17 macrophages macrophage NNS cord-346321-drhiqch0 124 18 with with IN cord-346321-drhiqch0 124 19 neuraminidase neuraminidase JJ cord-346321-drhiqch0 124 20 increased increase VBN cord-346321-drhiqch0 124 21 affinity affinity NN cord-346321-drhiqch0 124 22 of of IN cord-346321-drhiqch0 124 23 their -PRON- PRP$ cord-346321-drhiqch0 124 24 Fc Fc NNP cord-346321-drhiqch0 124 25 7 7 CD cord-346321-drhiqch0 124 26 R R NNP cord-346321-drhiqch0 124 27 II II NNP cord-346321-drhiqch0 124 28 for for IN cord-346321-drhiqch0 124 29 mouse mouse NN cord-346321-drhiqch0 124 30 IgG IgG NNP cord-346321-drhiqch0 124 31 1 1 CD cord-346321-drhiqch0 124 32 MAb MAb NNS cord-346321-drhiqch0 124 33 and and CC cord-346321-drhiqch0 124 34 resulted result VBD cord-346321-drhiqch0 124 35 in in IN cord-346321-drhiqch0 124 36 increased increase VBN cord-346321-drhiqch0 124 37 ADE ade NN cord-346321-drhiqch0 124 38 of of IN cord-346321-drhiqch0 124 39 the the DT cord-346321-drhiqch0 124 40 infection infection NN cord-346321-drhiqch0 124 41 by by IN cord-346321-drhiqch0 124 42 mouse mouse NN cord-346321-drhiqch0 124 43 anti anti JJ cord-346321-drhiqch0 124 44 - - JJ cord-346321-drhiqch0 124 45 dengue dengue JJ cord-346321-drhiqch0 124 46 virus virus NN cord-346321-drhiqch0 124 47 IgG igg NN cord-346321-drhiqch0 124 48 1 1 CD cord-346321-drhiqch0 124 49 MAb MAb NNPS cord-346321-drhiqch0 124 50 [ [ -LRB- cord-346321-drhiqch0 124 51 16 16 CD cord-346321-drhiqch0 124 52 ] ] -RRB- cord-346321-drhiqch0 124 53 . . . cord-346321-drhiqch0 125 1 This this DT cord-346321-drhiqch0 125 2 might may MD cord-346321-drhiqch0 125 3 be be VB cord-346321-drhiqch0 125 4 verified verify VBN cord-346321-drhiqch0 125 5 by by IN cord-346321-drhiqch0 125 6 a a DT cord-346321-drhiqch0 125 7 similar similar JJ cord-346321-drhiqch0 125 8 experiment experiment NN cord-346321-drhiqch0 125 9 with with IN cord-346321-drhiqch0 125 10 FIPV FIPV NNP cord-346321-drhiqch0 125 11 system system NN cord-346321-drhiqch0 125 12 . . . cord-346321-drhiqch0 126 1 Taken take VBN cord-346321-drhiqch0 126 2 all all DT cord-346321-drhiqch0 126 3 results result NNS cord-346321-drhiqch0 126 4 of of IN cord-346321-drhiqch0 126 5 the the DT cord-346321-drhiqch0 126 6 present present JJ cord-346321-drhiqch0 126 7 study study NN cord-346321-drhiqch0 126 8 together together RB cord-346321-drhiqch0 126 9 , , , cord-346321-drhiqch0 126 10 it -PRON- PRP cord-346321-drhiqch0 126 11 is be VBZ cord-346321-drhiqch0 126 12 indicated indicate VBN cord-346321-drhiqch0 126 13 that that IN cord-346321-drhiqch0 126 14 ADE ADE NNP cord-346321-drhiqch0 126 15 of of IN cord-346321-drhiqch0 126 16 FIPV FIPV NNS cord-346321-drhiqch0 126 17 infection infection NN cord-346321-drhiqch0 126 18 is be VBZ cord-346321-drhiqch0 126 19 mediated mediate VBN cord-346321-drhiqch0 126 20 by by IN cord-346321-drhiqch0 126 21 binding bind VBG cord-346321-drhiqch0 126 22 of of IN cord-346321-drhiqch0 126 23 Fc Fc NNP cord-346321-drhiqch0 126 24 region region NN cord-346321-drhiqch0 126 25 of of IN cord-346321-drhiqch0 126 26 anti anti JJ cord-346321-drhiqch0 126 27 - - JJ cord-346321-drhiqch0 126 28 FIPV fipv JJ cord-346321-drhiqch0 126 29 antibody antibody NN cord-346321-drhiqch0 126 30 to to IN cord-346321-drhiqch0 126 31 Fc Fc NNP cord-346321-drhiqch0 126 32 receptor receptor NN cord-346321-drhiqch0 126 33 expressed express VBN cord-346321-drhiqch0 126 34 on on IN cord-346321-drhiqch0 126 35 the the DT cord-346321-drhiqch0 126 36 target target NN cord-346321-drhiqch0 126 37 cells cell NNS cord-346321-drhiqch0 126 38 of of IN cord-346321-drhiqch0 126 39 FIPV FIPV NNS cord-346321-drhiqch0 126 40 . . . cord-346321-drhiqch0 127 1 This this DT cord-346321-drhiqch0 127 2 is be VBZ cord-346321-drhiqch0 127 3 supported support VBN cord-346321-drhiqch0 127 4 by by IN cord-346321-drhiqch0 127 5 finding find VBG cord-346321-drhiqch0 127 6 that that IN cord-346321-drhiqch0 127 7 any any DT cord-346321-drhiqch0 127 8 FIPV FIPV NNP cord-346321-drhiqch0 127 9 - - HYPH cord-346321-drhiqch0 127 10 neutralizing neutralize VBG cord-346321-drhiqch0 127 11 MAbs MAbs NNP cord-346321-drhiqch0 127 12 could could MD cord-346321-drhiqch0 127 13 not not RB cord-346321-drhiqch0 127 14 enhance enhance VB cord-346321-drhiqch0 127 15 FIPV FIPV NNS cord-346321-drhiqch0 127 16 infection infection NN cord-346321-drhiqch0 127 17 of of IN cord-346321-drhiqch0 127 18 Crandell Crandell NNP cord-346321-drhiqch0 127 19 feline feline JJ cord-346321-drhiqch0 127 20 kidney kidney NN cord-346321-drhiqch0 127 21 cells cell NNS cord-346321-drhiqch0 127 22 which which WDT cord-346321-drhiqch0 127 23 are be VBP cord-346321-drhiqch0 127 24 devoid devoid JJ cord-346321-drhiqch0 127 25 of of IN cord-346321-drhiqch0 127 26 Fc Fc NNP cord-346321-drhiqch0 127 27 R. R. NNP cord-346321-drhiqch0 128 1 The the DT cord-346321-drhiqch0 128 2 present present JJ cord-346321-drhiqch0 128 3 study study NN cord-346321-drhiqch0 128 4 , , , cord-346321-drhiqch0 128 5 however however RB cord-346321-drhiqch0 128 6 , , , cord-346321-drhiqch0 128 7 explored explore VBD cord-346321-drhiqch0 128 8 ADE ADE NNP cord-346321-drhiqch0 128 9 of of IN cord-346321-drhiqch0 128 10 FIPV FIPV NNS cord-346321-drhiqch0 128 11 infection infection NN cord-346321-drhiqch0 128 12 by by IN cord-346321-drhiqch0 128 13 in in FW cord-346321-drhiqch0 128 14 vitro vitro FW cord-346321-drhiqch0 128 15 experiments experiment NNS cord-346321-drhiqch0 128 16 in in IN cord-346321-drhiqch0 128 17 which which WDT cord-346321-drhiqch0 128 18 xenogeneic xenogeneic NNP cord-346321-drhiqch0 128 19 combination combination NN cord-346321-drhiqch0 128 20 of of IN cord-346321-drhiqch0 128 21 virus virus NN cord-346321-drhiqch0 128 22 targets target NNS cord-346321-drhiqch0 128 23 and and CC cord-346321-drhiqch0 128 24 anti anti JJ cord-346321-drhiqch0 128 25 - - JJ cord-346321-drhiqch0 128 26 FIPV FIPV NNP cord-346321-drhiqch0 128 27 antibody antibody NN cord-346321-drhiqch0 128 28 , , , cord-346321-drhiqch0 128 29 i.e. i.e. FW cord-346321-drhiqch0 128 30 , , , cord-346321-drhiqch0 128 31 feline feline JJ cord-346321-drhiqch0 128 32 alveolar alveolar NN cord-346321-drhiqch0 128 33 macrophages macrophage NNS cord-346321-drhiqch0 128 34 or or CC cord-346321-drhiqch0 128 35 human human JJ cord-346321-drhiqch0 128 36 monocyte monocyte NNP cord-346321-drhiqch0 128 37 U937 U937 NNP cord-346321-drhiqch0 128 38 cells cell NNS cord-346321-drhiqch0 128 39 and and CC cord-346321-drhiqch0 128 40 mouse mouse NN cord-346321-drhiqch0 128 41 anti anti NNP cord-346321-drhiqch0 128 42 - - NNP cord-346321-drhiqch0 128 43 FIPV FIPV NNP cord-346321-drhiqch0 128 44 S S NNP cord-346321-drhiqch0 128 45 protein protein NN cord-346321-drhiqch0 128 46 MAbs MAbs NNP cord-346321-drhiqch0 128 47 , , , cord-346321-drhiqch0 128 48 was be VBD cord-346321-drhiqch0 128 49 used use VBN cord-346321-drhiqch0 128 50 . . . cord-346321-drhiqch0 129 1 Therefore therefore RB cord-346321-drhiqch0 129 2 , , , cord-346321-drhiqch0 129 3 the the DT cord-346321-drhiqch0 129 4 findings finding NNS cord-346321-drhiqch0 129 5 in in IN cord-346321-drhiqch0 129 6 the the DT cord-346321-drhiqch0 129 7 present present JJ cord-346321-drhiqch0 129 8 study study NN cord-346321-drhiqch0 129 9 could could MD cord-346321-drhiqch0 129 10 not not RB cord-346321-drhiqch0 129 11 be be VB cord-346321-drhiqch0 129 12 applied apply VBN cord-346321-drhiqch0 129 13 directly directly RB cord-346321-drhiqch0 129 14 to to IN cord-346321-drhiqch0 129 15 ADE ADE NNP cord-346321-drhiqch0 129 16 of of IN cord-346321-drhiqch0 129 17 natural natural JJ cord-346321-drhiqch0 129 18 infection infection NN cord-346321-drhiqch0 129 19 in in IN cord-346321-drhiqch0 129 20 cats cat NNS cord-346321-drhiqch0 129 21 . . . cord-346321-drhiqch0 130 1 Schultz Schultz NNP cord-346321-drhiqch0 130 2 et et NNP cord-346321-drhiqch0 130 3 al al NNP cord-346321-drhiqch0 130 4 . . . cord-346321-drhiqch0 131 1 [ [ -LRB- cord-346321-drhiqch0 131 2 28 28 CD cord-346321-drhiqch0 131 3 ] ] -RRB- cord-346321-drhiqch0 131 4 reported report VBD cord-346321-drhiqch0 131 5 two two CD cord-346321-drhiqch0 131 6 subclasses subclass NNS cord-346321-drhiqch0 131 7 of of IN cord-346321-drhiqch0 131 8 feline feline NN cord-346321-drhiqch0 132 1 IgG. IgG. NNP cord-346321-drhiqch0 133 1 However however RB cord-346321-drhiqch0 133 2 , , , cord-346321-drhiqch0 133 3 biological biological JJ cord-346321-drhiqch0 133 4 properties property NNS cord-346321-drhiqch0 133 5 of of IN cord-346321-drhiqch0 133 6 feline feline JJ cord-346321-drhiqch0 133 7 IgG IgG NNP cord-346321-drhiqch0 133 8 subclasses subclass NNS cord-346321-drhiqch0 133 9 have have VBP cord-346321-drhiqch0 133 10 not not RB cord-346321-drhiqch0 133 11 yet yet RB cord-346321-drhiqch0 133 12 been be VBN cord-346321-drhiqch0 133 13 clarified clarify VBN cord-346321-drhiqch0 133 14 . . . cord-346321-drhiqch0 134 1 Further further JJ cord-346321-drhiqch0 134 2 study study NN cord-346321-drhiqch0 134 3 of of IN cord-346321-drhiqch0 134 4 the the DT cord-346321-drhiqch0 134 5 feline feline JJ cord-346321-drhiqch0 134 6 IgG IgG NNP cord-346321-drhiqch0 134 7 subclasses subclass NNS cord-346321-drhiqch0 134 8 and and CC cord-346321-drhiqch0 134 9 exploration exploration NN cord-346321-drhiqch0 134 10 of of IN cord-346321-drhiqch0 134 11 Fc Fc NNP cord-346321-drhiqch0 134 12 7 7 CD cord-346321-drhiqch0 134 13 R r NN cord-346321-drhiqch0 134 14 on on IN cord-346321-drhiqch0 134 15 feline feline JJ cord-346321-drhiqch0 134 16 cells cell NNS cord-346321-drhiqch0 134 17 are be VBP cord-346321-drhiqch0 134 18 mandatory mandatory JJ cord-346321-drhiqch0 134 19 , , , cord-346321-drhiqch0 134 20 and and CC cord-346321-drhiqch0 134 21 what what WP cord-346321-drhiqch0 134 22 IgG IgG NNP cord-346321-drhiqch0 134 23 subclass subclass NN cord-346321-drhiqch0 134 24 of of IN cord-346321-drhiqch0 134 25 anti anti JJ cord-346321-drhiqch0 134 26 - - JJ cord-346321-drhiqch0 134 27 FIPV FIPV NNP cord-346321-drhiqch0 134 28 antibody antibody NN cord-346321-drhiqch0 134 29 in in IN cord-346321-drhiqch0 134 30 the the DT cord-346321-drhiqch0 134 31 serum serum NN cord-346321-drhiqch0 134 32 of of IN cord-346321-drhiqch0 134 33 naturally naturally RB cord-346321-drhiqch0 134 34 infected infect VBN cord-346321-drhiqch0 134 35 cats cat NNS cord-346321-drhiqch0 134 36 enhances enhance VBZ cord-346321-drhiqch0 134 37 the the DT cord-346321-drhiqch0 134 38 FIPV FIPV NNS cord-346321-drhiqch0 134 39 infection infection NN cord-346321-drhiqch0 134 40 should should MD cord-346321-drhiqch0 134 41 be be VB cord-346321-drhiqch0 134 42 investigated investigate VBN cord-346321-drhiqch0 134 43 . . . cord-346321-drhiqch0 135 1 These these DT cord-346321-drhiqch0 135 2 studies study NNS cord-346321-drhiqch0 135 3 are be VBP cord-346321-drhiqch0 135 4 worthwhile worthwhile JJ cord-346321-drhiqch0 135 5 for for IN cord-346321-drhiqch0 135 6 determination determination NN cord-346321-drhiqch0 135 7 of of IN cord-346321-drhiqch0 135 8 basic basic JJ cord-346321-drhiqch0 135 9 pathogenesis pathogenesis NN cord-346321-drhiqch0 135 10 of of IN cord-346321-drhiqch0 135 11 FIP fip NN cord-346321-drhiqch0 135 12 and and CC cord-346321-drhiqch0 135 13 development development NN cord-346321-drhiqch0 135 14 of of IN cord-346321-drhiqch0 135 15 vaccines vaccine NNS cord-346321-drhiqch0 135 16 for for IN cord-346321-drhiqch0 135 17 prevention prevention NN cord-346321-drhiqch0 135 18 of of IN cord-346321-drhiqch0 135 19 FIPV FIPV NNP cord-346321-drhiqch0 135 20 infection infection NN cord-346321-drhiqch0 135 21 . . . cord-346321-drhiqch0 136 1 Monoclonal monoclonal JJ cord-346321-drhiqch0 136 2 antibodies antibody NNS cord-346321-drhiqch0 136 3 to to IN cord-346321-drhiqch0 136 4 Fc Fc NNP cord-346321-drhiqch0 136 5 receptors receptor NNS cord-346321-drhiqch0 136 6 for for IN cord-346321-drhiqch0 136 7 IgG IgG NNP cord-346321-drhiqch0 136 8 on on IN cord-346321-drhiqch0 136 9 human human JJ cord-346321-drhiqch0 136 10 mononudear mononudear JJ cord-346321-drhiqch0 136 11 phagocytes phagocyte NNS cord-346321-drhiqch0 136 12 : : : cord-346321-drhiqch0 136 13 antibody antibody NN cord-346321-drhiqch0 136 14 characterization characterization NN cord-346321-drhiqch0 136 15 and and CC cord-346321-drhiqch0 136 16 induction induction NN cord-346321-drhiqch0 136 17 of of IN cord-346321-drhiqch0 136 18 superoxide superoxide NN cord-346321-drhiqch0 136 19 production production NN cord-346321-drhiqch0 136 20 in in IN cord-346321-drhiqch0 136 21 a a DT cord-346321-drhiqch0 136 22 monocyte monocyte NNP cord-346321-drhiqch0 136 23 cell cell NN cord-346321-drhiqch0 136 24 line line NN cord-346321-drhiqch0 136 25 Experimental experimental JJ cord-346321-drhiqch0 136 26 inoculation inoculation NN cord-346321-drhiqch0 136 27 of of IN cord-346321-drhiqch0 136 28 cats cat NNS cord-346321-drhiqch0 136 29 with with IN cord-346321-drhiqch0 136 30 canine canine JJ cord-346321-drhiqch0 136 31 coronavirus coronavirus NN cord-346321-drhiqch0 136 32 and and CC cord-346321-drhiqch0 136 33 subsequent subsequent JJ cord-346321-drhiqch0 136 34 challenge challenge NN cord-346321-drhiqch0 136 35 with with IN cord-346321-drhiqch0 136 36 feline feline JJ cord-346321-drhiqch0 136 37 infectious infectious JJ cord-346321-drhiqch0 136 38 peritonitis peritonitis NN cord-346321-drhiqch0 136 39 virus virus NN cord-346321-drhiqch0 136 40 Interaction Interaction NNP cord-346321-drhiqch0 136 41 of of IN cord-346321-drhiqch0 136 42 West West NNP cord-346321-drhiqch0 136 43 Nile Nile NNP cord-346321-drhiqch0 136 44 virus virus NN cord-346321-drhiqch0 136 45 with with IN cord-346321-drhiqch0 136 46 primary primary JJ cord-346321-drhiqch0 136 47 murine murine JJ cord-346321-drhiqch0 136 48 macrophages macrophage NNS cord-346321-drhiqch0 136 49 : : : cord-346321-drhiqch0 136 50 role role NN cord-346321-drhiqch0 136 51 of of IN cord-346321-drhiqch0 136 52 cell cell NN cord-346321-drhiqch0 136 53 activation activation NN cord-346321-drhiqch0 136 54 and and CC cord-346321-drhiqch0 136 55 receptors receptor NNS cord-346321-drhiqch0 136 56 for for IN cord-346321-drhiqch0 136 57 antibody antibody NN cord-346321-drhiqch0 136 58 and and CC cord-346321-drhiqch0 136 59 complement complement VB cord-346321-drhiqch0 136 60 Monoclonal monoclonal JJ cord-346321-drhiqch0 136 61 antibodies antibody NNS cord-346321-drhiqch0 136 62 to to IN cord-346321-drhiqch0 136 63 Sindbis Sindbis NNP cord-346321-drhiqch0 136 64 virus virus NN cord-346321-drhiqch0 136 65 glycoprotein glycoprotein NN cord-346321-drhiqch0 136 66 E1 e1 NN cord-346321-drhiqch0 136 67 can can MD cord-346321-drhiqch0 136 68 neutralize neutralize VB cord-346321-drhiqch0 136 69 , , , cord-346321-drhiqch0 136 70 enhance enhance VB cord-346321-drhiqch0 136 71 infectivity infectivity NN cord-346321-drhiqch0 136 72 , , , cord-346321-drhiqch0 136 73 and and CC cord-346321-drhiqch0 136 74 independently independently RB cord-346321-drhiqch0 136 75 inhibit inhibit VB cord-346321-drhiqch0 136 76 haemagglutination haemagglutination NN cord-346321-drhiqch0 136 77 or or CC cord-346321-drhiqch0 136 78 haemolysis haemolysis NNP cord-346321-drhiqch0 136 79 Monoclonal Monoclonal NNP cord-346321-drhiqch0 136 80 antibody antibody NN cord-346321-drhiqch0 136 81 analysis analysis NN cord-346321-drhiqch0 136 82 of of IN cord-346321-drhiqch0 136 83 neutralization neutralization NN cord-346321-drhiqch0 136 84 and and CC cord-346321-drhiqch0 136 85 antibody antibody NN cord-346321-drhiqch0 136 86 - - HYPH cord-346321-drhiqch0 136 87 dependent dependent JJ cord-346321-drhiqch0 136 88 enhancement enhancement NN cord-346321-drhiqch0 136 89 of of IN cord-346321-drhiqch0 136 90 feline feline JJ cord-346321-drhiqch0 136 91 infectious infectious JJ cord-346321-drhiqch0 136 92 peritonitis peritonitis NN cord-346321-drhiqch0 136 93 virus virus NN cord-346321-drhiqch0 136 94 Human Human NNP cord-346321-drhiqch0 136 95 neutrophilic neutrophilic NN cord-346321-drhiqch0 137 1 Fcq fcq NN cord-346321-drhiqch0 137 2 , , , cord-346321-drhiqch0 137 3 receptor receptor NN cord-346321-drhiqch0 137 4 distribution distribution NN cord-346321-drhiqch0 137 5 and and CC cord-346321-drhiqch0 137 6 structure structure NN cord-346321-drhiqch0 137 7 Pathogenesis Pathogenesis NNP cord-346321-drhiqch0 137 8 of of IN cord-346321-drhiqch0 137 9 dengue dengue NN cord-346321-drhiqch0 137 10 : : : cord-346321-drhiqch0 137 11 challenges challenge NNS cord-346321-drhiqch0 137 12 to to IN cord-346321-drhiqch0 137 13 molecular molecular JJ cord-346321-drhiqch0 137 14 Biology Biology NNP cord-346321-drhiqch0 137 15 Antibody Antibody NNP cord-346321-drhiqch0 137 16 - - HYPH cord-346321-drhiqch0 137 17 enhanced enhance VBN cord-346321-drhiqch0 137 18 dengue dengue NN cord-346321-drhiqch0 137 19 virus virus NN cord-346321-drhiqch0 137 20 infection infection NN cord-346321-drhiqch0 137 21 in in IN cord-346321-drhiqch0 137 22 primate primate JJ cord-346321-drhiqch0 137 23 teukocytes teukocyte NNS cord-346321-drhiqch0 137 24 Dengue dengue NN cord-346321-drhiqch0 137 25 viruses virus NNS cord-346321-drhiqch0 137 26 and and CC cord-346321-drhiqch0 137 27 mononuclear mononuclear JJ cord-346321-drhiqch0 137 28 phagocytes phagocyte NNS cord-346321-drhiqch0 137 29 . . . cord-346321-drhiqch0 138 1 I. I. NNP cord-346321-drhiqch0 138 2 Infection infection NN cord-346321-drhiqch0 138 3 enhancement enhancement NN cord-346321-drhiqch0 138 4 by by IN cord-346321-drhiqch0 138 5 nonneutralizing nonneutralize VBG cord-346321-drhiqch0 138 6 antibody antibody NN cord-346321-drhiqch0 138 7 Heterogeneity heterogeneity NN cord-346321-drhiqch0 138 8 of of IN cord-346321-drhiqch0 138 9 infection infection NN cord-346321-drhiqch0 138 10 enhancement enhancement NN cord-346321-drhiqch0 138 11 of of IN cord-346321-drhiqch0 138 12 dengue dengue NN cord-346321-drhiqch0 138 13 2 2 CD cord-346321-drhiqch0 138 14 strains strain NNS cord-346321-drhiqch0 138 15 by by IN cord-346321-drhiqch0 138 16 monoclonal monoclonal JJ cord-346321-drhiqch0 138 17 antibodies antibody NNS cord-346321-drhiqch0 138 18 Characterization characterization NN cord-346321-drhiqch0 138 19 of of IN cord-346321-drhiqch0 138 20 monoelonal monoelonal JJ cord-346321-drhiqch0 138 21 antibodies antibody NNS cord-346321-drhiqch0 138 22 against against IN cord-346321-drhiqch0 138 23 feline feline JJ cord-346321-drhiqch0 138 24 infectious infectious JJ cord-346321-drhiqch0 138 25 peritonitis peritonitis NN cord-346321-drhiqch0 138 26 virus virus NN cord-346321-drhiqch0 138 27 type type NN cord-346321-drhiqch0 138 28 II II NNP cord-346321-drhiqch0 138 29 and and CC cord-346321-drhiqch0 138 30 antigenic antigenic JJ cord-346321-drhiqch0 138 31 relationship relationship NN cord-346321-drhiqch0 138 32 between between IN cord-346321-drhiqch0 138 33 feline feline JJ cord-346321-drhiqch0 138 34 , , , cord-346321-drhiqch0 138 35 porcine porcine JJ cord-346321-drhiqch0 138 36 and and CC cord-346321-drhiqch0 138 37 canine canine JJ cord-346321-drhiqch0 138 38 coronaviruses coronaviruse NNS cord-346321-drhiqch0 139 1 A a DT cord-346321-drhiqch0 139 2 study study NN cord-346321-drhiqch0 139 3 on on IN cord-346321-drhiqch0 139 4 the the DT cord-346321-drhiqch0 139 5 mechanism mechanism NN cord-346321-drhiqch0 139 6 of of IN cord-346321-drhiqch0 139 7 antibody antibody NN cord-346321-drhiqch0 139 8 - - HYPH cord-346321-drhiqch0 139 9 dependent dependent JJ cord-346321-drhiqch0 139 10 enhancement enhancement NN cord-346321-drhiqch0 139 11 of of IN cord-346321-drhiqch0 139 12 feline feline JJ cord-346321-drhiqch0 139 13 infectious infectious JJ cord-346321-drhiqch0 139 14 peritonitis peritonitis NN cord-346321-drhiqch0 139 15 virus virus NN cord-346321-drhiqch0 139 16 infection infection NN cord-346321-drhiqch0 139 17 in in IN cord-346321-drhiqch0 139 18 feline feline JJ cord-346321-drhiqch0 139 19 macrophages macrophage NNS cord-346321-drhiqch0 139 20 by by IN cord-346321-drhiqch0 139 21 monoctonal monoctonal NNP cord-346321-drhiqch0 139 22 antibodies antibody NNS cord-346321-drhiqch0 139 23 Enhancement Enhancement NNP cord-346321-drhiqch0 139 24 and and CC cord-346321-drhiqch0 139 25 neutralization neutralization NN cord-346321-drhiqch0 139 26 of of IN cord-346321-drhiqch0 139 27 feline feline JJ cord-346321-drhiqch0 139 28 infectious infectious JJ cord-346321-drhiqch0 139 29 peritonitis peritonitis NN cord-346321-drhiqch0 139 30 virus virus NN cord-346321-drhiqch0 139 31 infection infection NN cord-346321-drhiqch0 139 32 in in IN cord-346321-drhiqch0 139 33 feline feline JJ cord-346321-drhiqch0 139 34 macrophages macrophage NNS cord-346321-drhiqch0 139 35 by by IN cord-346321-drhiqch0 139 36 neutralizing neutralize VBG cord-346321-drhiqch0 139 37 monoclonal monoclonal JJ cord-346321-drhiqch0 139 38 antibodies antibody NNS cord-346321-drhiqch0 139 39 recognizing recognize VBG cord-346321-drhiqch0 139 40 different different JJ cord-346321-drhiqch0 139 41 epitopes epitope NNS cord-346321-drhiqch0 140 1 Studies study NNS cord-346321-drhiqch0 140 2 on on IN cord-346321-drhiqch0 140 3 the the DT cord-346321-drhiqch0 140 4 mechanism mechanism NN cord-346321-drhiqch0 140 5 of of IN cord-346321-drhiqch0 140 6 antibody antibody NN cord-346321-drhiqch0 140 7 - - HYPH cord-346321-drhiqch0 140 8 mediated mediate VBN cord-346321-drhiqch0 140 9 enhancement enhancement NN cord-346321-drhiqch0 140 10 of of IN cord-346321-drhiqch0 140 11 Getah Getah NNP cord-346321-drhiqch0 140 12 virus virus NN cord-346321-drhiqch0 140 13 infectivity infectivity NN cord-346321-drhiqch0 140 14 Human human JJ cord-346321-drhiqch0 140 15 monocytes monocyte NNS cord-346321-drhiqch0 140 16 and and CC cord-346321-drhiqch0 140 17 U937 u937 CD cord-346321-drhiqch0 140 18 cells cell NNS cord-346321-drhiqch0 140 19 bear bear VBP cord-346321-drhiqch0 140 20 two two CD cord-346321-drhiqch0 140 21 distinct distinct JJ cord-346321-drhiqch0 140 22 Fc Fc NNP cord-346321-drhiqch0 140 23 receptors receptor NNS cord-346321-drhiqch0 140 24 for for IN cord-346321-drhiqch0 140 25 IgG IgG NNP cord-346321-drhiqch0 140 26 Neuraminidase Neuraminidase NNP cord-346321-drhiqch0 141 1 augments augment VBZ cord-346321-drhiqch0 141 2 Fc Fc NNP cord-346321-drhiqch0 141 3 y y NNP cord-346321-drhiqch0 141 4 receptor receptor NN cord-346321-drhiqch0 141 5 II II NNP cord-346321-drhiqch0 141 6 - - HYPH cord-346321-drhiqch0 141 7 mediated mediate VBN cord-346321-drhiqch0 141 8 antibody antibody NN cord-346321-drhiqch0 141 9 - - HYPH cord-346321-drhiqch0 141 10 dependent dependent JJ cord-346321-drhiqch0 141 11 enhancement enhancement NN cord-346321-drhiqch0 141 12 of of IN cord-346321-drhiqch0 141 13 dengue dengue NN cord-346321-drhiqch0 141 14 virus virus NN cord-346321-drhiqch0 141 15 infection infection NN cord-346321-drhiqch0 141 16 Dengue dengue NN cord-346321-drhiqch0 141 17 4 4 CD cord-346321-drhiqch0 141 18 virus virus NN cord-346321-drhiqch0 141 19 monoctonal monoctonal JJ cord-346321-drhiqch0 141 20 antibodies antibody NNS cord-346321-drhiqch0 141 21 identify identify VBP cord-346321-drhiqch0 141 22 epitopes epitope NNS cord-346321-drhiqch0 141 23 that that WDT cord-346321-drhiqch0 141 24 mediate mediate VBP cord-346321-drhiqch0 141 25 immune immune JJ cord-346321-drhiqch0 141 26 infection infection NN cord-346321-drhiqch0 141 27 enhancement enhancement NN cord-346321-drhiqch0 141 28 of of IN cord-346321-drhiqch0 141 29 dengue dengue NN cord-346321-drhiqch0 141 30 2 2 CD cord-346321-drhiqch0 141 31 viruses virus NNS cord-346321-drhiqch0 141 32 Antibody antibody NN cord-346321-drhiqch0 141 33 - - HYPH cord-346321-drhiqch0 141 34 mediated mediate VBN cord-346321-drhiqch0 141 35 growth growth NN cord-346321-drhiqch0 141 36 of of IN cord-346321-drhiqch0 141 37 influenza influenza NN cord-346321-drhiqch0 141 38 A a DT cord-346321-drhiqch0 141 39 NWS NWS NNP cord-346321-drhiqch0 141 40 virus virus NN cord-346321-drhiqch0 141 41 in in IN cord-346321-drhiqch0 141 42 macrophagelike macrophagelike JJ cord-346321-drhiqch0 141 43 cell cell NN cord-346321-drhiqch0 141 44 line line NN cord-346321-drhiqch0 141 45 P388D1 P388D1 NNP cord-346321-drhiqch0 141 46 Identification Identification NNP cord-346321-drhiqch0 141 47 of of IN cord-346321-drhiqch0 141 48 antigenic antigenic JJ cord-346321-drhiqch0 141 49 sites site NNS cord-346321-drhiqch0 141 50 mediating mediate VBG cord-346321-drhiqch0 141 51 antibody antibody NN cord-346321-drhiqch0 141 52 - - HYPH cord-346321-drhiqch0 141 53 dependent dependent JJ cord-346321-drhiqch0 141 54 enhancement enhancement NN cord-346321-drhiqch0 141 55 of of IN cord-346321-drhiqch0 141 56 feline feline JJ cord-346321-drhiqch0 141 57 infectious infectious JJ cord-346321-drhiqch0 141 58 peritonitis peritonitis NN cord-346321-drhiqch0 141 59 virus virus NN cord-346321-drhiqch0 141 60 infectivity infectivity NN cord-346321-drhiqch0 141 61 Monoclonal monoclonal JJ cord-346321-drhiqch0 141 62 antibodies antibody NNS cord-346321-drhiqch0 141 63 to to IN cord-346321-drhiqch0 141 64 the the DT cord-346321-drhiqch0 141 65 spike spike NN cord-346321-drhiqch0 141 66 protein protein NN cord-346321-drhiqch0 141 67 of of IN cord-346321-drhiqch0 141 68 feline feline JJ cord-346321-drhiqch0 141 69 infectious infectious JJ cord-346321-drhiqch0 141 70 peritonitis peritonitis NN cord-346321-drhiqch0 141 71 virus virus NN cord-346321-drhiqch0 141 72 mediate mediate VB cord-346321-drhiqch0 141 73 antibodydependent antibodydependent NN cord-346321-drhiqch0 141 74 enhancement enhancement NN cord-346321-drhiqch0 141 75 of of IN cord-346321-drhiqch0 141 76 infection infection NN cord-346321-drhiqch0 141 77 of of IN cord-346321-drhiqch0 141 78 feline feline JJ cord-346321-drhiqch0 141 79 macrophages macrophage NNS cord-346321-drhiqch0 141 80 Attempted attempt VBD cord-346321-drhiqch0 141 81 immunization immunization NN cord-346321-drhiqch0 141 82 of of IN cord-346321-drhiqch0 141 83 cats cat NNS cord-346321-drhiqch0 141 84 against against IN cord-346321-drhiqch0 141 85 feline feline JJ cord-346321-drhiqch0 141 86 infectious infectious JJ cord-346321-drhiqch0 141 87 peritonitis peritonitis NN cord-346321-drhiqch0 141 88 , , , cord-346321-drhiqch0 141 89 using use VBG cord-346321-drhiqch0 141 90 avirulent avirulent NNP cord-346321-drhiqch0 141 91 live live JJ cord-346321-drhiqch0 141 92 virus virus NN cord-346321-drhiqch0 141 93 or or CC cord-346321-drhiqch0 141 94 sublethal sublethal JJ cord-346321-drhiqch0 141 95 amounts amount NNS cord-346321-drhiqch0 141 96 of of IN cord-346321-drhiqch0 141 97 virulent virulent JJ cord-346321-drhiqch0 141 98 virus virus NN cord-346321-drhiqch0 141 99 Immunologic immunologic JJ cord-346321-drhiqch0 141 100 phenomena phenomenon NNS cord-346321-drhiqch0 141 101 in in IN cord-346321-drhiqch0 141 102 the the DT cord-346321-drhiqch0 141 103 effusive effusive JJ cord-346321-drhiqch0 141 104 form form NN cord-346321-drhiqch0 141 105 of of IN cord-346321-drhiqch0 141 106 feline feline JJ cord-346321-drhiqch0 141 107 infectious infectious JJ cord-346321-drhiqch0 141 108 peritonitis peritonitis NN cord-346321-drhiqch0 141 109 Pathogenicity Pathogenicity NNP cord-346321-drhiqch0 141 110 studies study NNS cord-346321-drhiqch0 141 111 of of IN cord-346321-drhiqch0 141 112 feline feline JJ cord-346321-drhiqch0 141 113 coronavirus coronavirus NN cord-346321-drhiqch0 142 1 isolates isolate VBZ cord-346321-drhiqch0 142 2 79 79 CD cord-346321-drhiqch0 142 3 - - SYM cord-346321-drhiqch0 142 4 1146 1146 CD cord-346321-drhiqch0 142 5 and and CC cord-346321-drhiqch0 142 6 79 79 CD cord-346321-drhiqch0 142 7 - - HYPH cord-346321-drhiqch0 142 8 1683 1683 CD cord-346321-drhiqch0 143 1 An an DT cord-346321-drhiqch0 143 2 enteric enteric JJ cord-346321-drhiqch0 143 3 coronavirus coronavirus NN cord-346321-drhiqch0 143 4 infection infection NN cord-346321-drhiqch0 143 5 of of IN cord-346321-drhiqch0 143 6 cats cat NNS cord-346321-drhiqch0 143 7 and and CC cord-346321-drhiqch0 143 8 its -PRON- PRP$ cord-346321-drhiqch0 143 9 relationship relationship NN cord-346321-drhiqch0 143 10 to to IN cord-346321-drhiqch0 143 11 feline feline JJ cord-346321-drhiqch0 143 12 infectious infectious JJ cord-346321-drhiqch0 143 13 peritonitis peritonitis NN cord-346321-drhiqch0 143 14 Virologic Virologic NNP cord-346321-drhiqch0 143 15 and and CC cord-346321-drhiqch0 143 16 immunologic immunologic JJ cord-346321-drhiqch0 143 17 aspects aspect NNS cord-346321-drhiqch0 143 18 of of IN cord-346321-drhiqch0 143 19 feline feline JJ cord-346321-drhiqch0 143 20 infectious infectious JJ cord-346321-drhiqch0 143 21 peritonitis peritonitis NN cord-346321-drhiqch0 143 22 virus virus NN cord-346321-drhiqch0 143 23 infection infection NN cord-346321-drhiqch0 143 24 Antibody Antibody NNP cord-346321-drhiqch0 143 25 - - HYPH cord-346321-drhiqch0 143 26 mediated mediate VBN cord-346321-drhiqch0 143 27 enhancement enhancement NN cord-346321-drhiqch0 143 28 of of IN cord-346321-drhiqch0 143 29 flavivirus flavivirus JJ cord-346321-drhiqch0 143 30 replication replication NN cord-346321-drhiqch0 143 31 in in IN cord-346321-drhiqch0 143 32 macrophage macrophage NN cord-346321-drhiqch0 143 33 - - HYPH cord-346321-drhiqch0 143 34 like like JJ cord-346321-drhiqch0 143 35 cell cell NN cord-346321-drhiqch0 143 36 lines line NNS cord-346321-drhiqch0 143 37 Growth Growth NNP cord-346321-drhiqch0 143 38 of of IN cord-346321-drhiqch0 143 39 17 17 CD cord-346321-drhiqch0 143 40 D D NNP cord-346321-drhiqch0 143 41 yellow yellow JJ cord-346321-drhiqch0 143 42 fever fever NN cord-346321-drhiqch0 143 43 virus virus NN cord-346321-drhiqch0 143 44 in in IN cord-346321-drhiqch0 143 45 a a DT cord-346321-drhiqch0 143 46 macrophage macrophage NN cord-346321-drhiqch0 143 47 - - HYPH cord-346321-drhiqch0 143 48 like like JJ cord-346321-drhiqch0 143 49 cell cell NN cord-346321-drhiqch0 143 50 line line NN cord-346321-drhiqch0 143 51 , , , cord-346321-drhiqch0 143 52 U937 u937 CD cord-346321-drhiqch0 143 53 : : : cord-346321-drhiqch0 143 54 role role NN cord-346321-drhiqch0 143 55 of of IN cord-346321-drhiqch0 143 56 Fc Fc NNP cord-346321-drhiqch0 143 57 and and CC cord-346321-drhiqch0 143 58 viral viral JJ cord-346321-drhiqch0 143 59 receptors receptor NNS cord-346321-drhiqch0 143 60 in in IN cord-346321-drhiqch0 143 61 antibody antibody NN cord-346321-drhiqch0 143 62 - - HYPH cord-346321-drhiqch0 143 63 mediated mediate VBN cord-346321-drhiqch0 143 64 infection infection NN cord-346321-drhiqch0 143 65 Feline feline JJ cord-346321-drhiqch0 143 66 immunoglobulins immunoglobulin NNS cord-346321-drhiqch0 143 67 Attempted attempt VBD cord-346321-drhiqch0 143 68 immunisation immunisation NN cord-346321-drhiqch0 143 69 of of IN cord-346321-drhiqch0 143 70 cats cat NNS cord-346321-drhiqch0 143 71 against against IN cord-346321-drhiqch0 143 72 feline feline JJ cord-346321-drhiqch0 143 73 infectious infectious JJ cord-346321-drhiqch0 143 74 peritonitis peritonitis NN cord-346321-drhiqch0 143 75 using use VBG cord-346321-drhiqch0 143 76 canine canine JJ cord-346321-drhiqch0 143 77 coronavirus coronavirus NN cord-346321-drhiqch0 144 1 The the DT cord-346321-drhiqch0 144 2 sites site NNS cord-346321-drhiqch0 144 3 of of IN cord-346321-drhiqch0 144 4 early early JJ cord-346321-drhiqch0 144 5 viral viral JJ cord-346321-drhiqch0 144 6 replication replication NN cord-346321-drhiqch0 144 7 in in IN cord-346321-drhiqch0 144 8 feline feline JJ cord-346321-drhiqch0 144 9 infectious infectious JJ cord-346321-drhiqch0 144 10 peritonitis peritonitis NN cord-346321-drhiqch0 144 11 Antibody antibody NN cord-346321-drhiqch0 144 12 - - HYPH cord-346321-drhiqch0 144 13 enhanced enhance VBN cord-346321-drhiqch0 144 14 infection infection NN cord-346321-drhiqch0 144 15 by by IN cord-346321-drhiqch0 144 16 HIV-1 HIV-1 NNP cord-346321-drhiqch0 144 17 via via IN cord-346321-drhiqch0 144 18 Fc Fc NNP cord-346321-drhiqch0 144 19 receptor receptor NN cord-346321-drhiqch0 144 20 - - HYPH cord-346321-drhiqch0 144 21 mediated mediate VBN cord-346321-drhiqch0 144 22 entry entry NN cord-346321-drhiqch0 144 23 Function function NN cord-346321-drhiqch0 144 24 and and CC cord-346321-drhiqch0 144 25 heterogeneity heterogeneity NN cord-346321-drhiqch0 144 26 of of IN cord-346321-drhiqch0 144 27 human human JJ cord-346321-drhiqch0 144 28 Fc Fc NNP cord-346321-drhiqch0 144 29 receptors receptor NNS cord-346321-drhiqch0 144 30 for for IN cord-346321-drhiqch0 144 31 immunoglobulin immunoglobulin NN cord-346321-drhiqch0 144 32 G G NNP cord-346321-drhiqch0 144 33 Early early JJ cord-346321-drhiqch0 144 34 death death NN cord-346321-drhiqch0 144 35 after after IN cord-346321-drhiqch0 144 36 feline feline JJ cord-346321-drhiqch0 144 37 infectious infectious JJ cord-346321-drhiqch0 144 38 peritonitis peritonitis NN cord-346321-drhiqch0 144 39 virus virus NN cord-346321-drhiqch0 144 40 challenge challenge NN cord-346321-drhiqch0 144 41 due due JJ cord-346321-drhiqch0 144 42 to to IN cord-346321-drhiqch0 144 43 recombinant recombinant JJ cord-346321-drhiqch0 144 44 vaccinia vaccinia NN cord-346321-drhiqch0 144 45 virus virus NN cord-346321-drhiqch0 144 46 immunization immunization NN cord-346321-drhiqch0 144 47 Antibody Antibody NNP cord-346321-drhiqch0 144 48 - - HYPH cord-346321-drhiqch0 144 49 mediated mediate VBN cord-346321-drhiqch0 144 50 enhancement enhancement NN cord-346321-drhiqch0 144 51 of of IN cord-346321-drhiqch0 144 52 disease disease NN cord-346321-drhiqch0 144 53 in in IN cord-346321-drhiqch0 144 54 feline feline JJ cord-346321-drhiqch0 144 55 infectious infectious JJ cord-346321-drhiqch0 144 56 peritonitis peritonitis NN cord-346321-drhiqch0 144 57 : : : cord-346321-drhiqch0 144 58 comparisons comparison NNS cord-346321-drhiqch0 144 59 with with IN cord-346321-drhiqch0 144 60 dengue dengue NN cord-346321-drhiqch0 144 61 hemorrhagic hemorrhagic JJ cord-346321-drhiqch0 144 62 fever fever NN cord-346321-drhiqch0 144 63 Cross cross NN cord-346321-drhiqch0 144 64 - - HYPH cord-346321-drhiqch0 144 65 protection protection JJ cord-346321-drhiqch0 144 66 studies study NNS cord-346321-drhiqch0 144 67 between between IN cord-346321-drhiqch0 144 68 feline feline JJ cord-346321-drhiqch0 144 69 infectious infectious JJ cord-346321-drhiqch0 144 70 peritonitis peritonitis NN cord-346321-drhiqch0 144 71 and and CC cord-346321-drhiqch0 144 72 porcine porcine JJ cord-346321-drhiqch0 144 73 transmissible transmissible JJ cord-346321-drhiqch0 144 74 gastroenteritis gastroenteritis NN cord-346321-drhiqch0 144 75 viruses virus NNS cord-346321-drhiqch0 145 1 This this DT cord-346321-drhiqch0 145 2 work work NN cord-346321-drhiqch0 145 3 was be VBD cord-346321-drhiqch0 145 4 supported support VBN cord-346321-drhiqch0 145 5 by by IN cord-346321-drhiqch0 145 6 private private JJ cord-346321-drhiqch0 145 7 contributions contribution NNS cord-346321-drhiqch0 145 8 of of IN cord-346321-drhiqch0 145 9 Sankyo Sankyo NNP cord-346321-drhiqch0 145 10 Co. Co. NNP cord-346321-drhiqch0 145 11 , , , cord-346321-drhiqch0 145 12 Ltd. Ltd. NNP cord-346321-drhiqch0 145 13 , , , cord-346321-drhiqch0 145 14 Ajinomoto Ajinomoto NNP cord-346321-drhiqch0 145 15 General General NNP cord-346321-drhiqch0 145 16 Foods Foods NNPS cord-346321-drhiqch0 145 17 , , , cord-346321-drhiqch0 145 18 Inc. Inc. NNP cord-346321-drhiqch0 145 19 and and CC cord-346321-drhiqch0 145 20 Dainippon Dainippon NNP cord-346321-drhiqch0 145 21 Pharmaceutical Pharmaceutical NNP cord-346321-drhiqch0 145 22 Co. Co. NNP cord-346321-drhiqch0 145 23 , , , cord-346321-drhiqch0 145 24 Ltd. Ltd. NNP cord-346321-drhiqch0 145 25 , , , cord-346321-drhiqch0 145 26 Japan Japan NNP cord-346321-drhiqch0 145 27 . . . cord-346321-drhiqch0 146 1 Authors author NNS cord-346321-drhiqch0 146 2 ' ' POS cord-346321-drhiqch0 146 3 address address NN cord-346321-drhiqch0 146 4 : : : cord-346321-drhiqch0 146 5 Dr. Dr. NNP cord-346321-drhiqch0 146 6 T. T. NNP cord-346321-drhiqch0 146 7 Hohdatsu Hohdatsu NNP cord-346321-drhiqch0 146 8 , , , cord-346321-drhiqch0 146 9 Department Department NNP cord-346321-drhiqch0 146 10 of of IN cord-346321-drhiqch0 146 11 Veterinary Veterinary NNP cord-346321-drhiqch0 146 12 Infectious Infectious NNP cord-346321-drhiqch0 146 13 Diseases Diseases NNPS cord-346321-drhiqch0 146 14 , , , cord-346321-drhiqch0 146 15 School School NNP cord-346321-drhiqch0 146 16 of of IN cord-346321-drhiqch0 146 17 Veterinary Veterinary NNP cord-346321-drhiqch0 146 18 Medicine Medicine NNP cord-346321-drhiqch0 146 19 and and CC cord-346321-drhiqch0 146 20 Animal Animal NNP cord-346321-drhiqch0 146 21 Sciences Sciences NNPS cord-346321-drhiqch0 146 22 , , , cord-346321-drhiqch0 146 23 Kitasato Kitasato NNP cord-346321-drhiqch0 146 24 University University NNP cord-346321-drhiqch0 146 25 , , , cord-346321-drhiqch0 146 26 Towada Towada NNP cord-346321-drhiqch0 146 27 , , , cord-346321-drhiqch0 146 28 Aomori Aomori NNP cord-346321-drhiqch0 146 29 034 034 CD cord-346321-drhiqch0 146 30 , , , cord-346321-drhiqch0 146 31 Japan Japan NNP cord-346321-drhiqch0 146 32 . . . cord-346321-drhiqch0 147 1 Received Received NNP cord-346321-drhiqch0 147 2 May May NNP cord-346321-drhiqch0 147 3 24 24 CD cord-346321-drhiqch0 147 4 , , , cord-346321-drhiqch0 147 5 1994 1994 CD cord-346321-drhiqch0 147 6 _SP