id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-352190-1987sfyz	Xia, Hongyue	Adaptive Evolution of Feline Coronavirus Genes Based on Selection Analysis	2020-08-13		.txt	text/plain	4274	222	54	PURPOSE: We investigated sequences of the feline coronaviruses (FCoV), which include feline enteric coronavirus (FECV) and feline infectious peritonitis virus (FIPV), from China and other countries to gain insight into the adaptive evolution of this virus. A greater number of sites in each gene experienced negative rather than positive selection, which suggests that most of the protein sequence must be conservatively maintained for virus survival. The goal of our study is to increase the sampling of FCoV in China and to also examine the selective pressures acting on the genes of these viruses isolated from different parts of the world. To detect the presence of positive selection in the FCoV sequences from the different countries, we applied the branch, site, and branch-site tests from the PAML suit [18] . By analyzing the selective pressure experienced by genes in the FCoV genome involved in replication, entry, and virulence, we have identified a few sites that potentially experienced adaptive evolution.	./cache/cord-352190-1987sfyz.txt	./txt/cord-352190-1987sfyz.txt