id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-354730-hfau2odb	Wang, Rong	Antagonizing Interferon-Mediated Immune Response by Porcine Reproductive and Respiratory Syndrome Virus	2014-07-03		.txt	text/plain	4923	312	45	PRRSV interplays with host IFN production and IFN-activated signaling, which may contribute to the delayed onset and low level of neutralizing antibodies, as well as weak cell-mediated immune response in infected pigs. This review summarizes the recent advances in the research of PRRSV interference with IFN-mediated innate immunity, the viral proteins involved, and their molecular mechanisms, as well as diverse effects by different strains and in different cell types. These transcription activation factors translocate into the nucleus and result in induction of type I IFNs and expression of inflammatory cytokines, which not only lead to an antiviral state of the neighboring uninfected cells, but also serve as key regulators to evoke adaptive immune response. Porcine reproductive and respiratory syndrome virus nonstructural protein 1 modulates host innate immune response by antagonizing IRF3 activation Porcine reproductive and respiratory syndrome virus inhibits type I interferon signaling by blocking STAT1/STAT2 nuclear translocation	./cache/cord-354730-hfau2odb.txt	./txt/cord-354730-hfau2odb.txt