id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-102219-d3gkfo7s	Perzel Mandell, Kira A.	Characterizing the dynamic and functional DNA methylation landscape in the developing human cortex	2019-10-30		.txt	text/plain	5038	231	47	In the present report, we describe the use of whole genome bisulfite sequencing (WGBS) to capture an unbiased map of the DNAm landscape, and to characterize both CpG and CpH methylation during prenatal brain development. We performed whole genome bisulfite sequencing (WGBS) to better characterize the shifting DNAm landscape in the developing human dorsolateral prefrontal cortex (DLPFC) in 20 prenatal samples during the second trimester in utero (Table S1 ). We found that DNAm changes were abundant even during this relatively restricted period in prenatal development, with 36,546 CpG sites differentially methylated across the ages of 14-20 post-conception weeks (PCW, at FDR < 0.05, Table S3 ). The top biological processes associated with genes containing differentially methylated CpGs across age were related to axon development and guidance, and regulation of neuron projection ( Figure S4 , Table S8 ).	./cache/cord-102219-d3gkfo7s.txt	./txt/cord-102219-d3gkfo7s.txt