id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-102729-b1q7gbd6	Mickael, Alexandra	Asip (Agouti-signaling protein) aggression gene regulate auditory processing genes in mice	2020-06-12		.txt	text/plain	4430	281	48	ASIP (nonagouti) gene plays a vital role in regulating the melanocortin GPCRs family function, and it is responsible for regulating aggression in mice. We found that ASIP KO in mice upregulates several genes controlling auditory function, including Phox2b, Mpk13, Fat2, Neurod2, Slc18a3, Gon4l Gbx2, Slc6a3(Dat1) Aldh1a7 Tyrp1 and Lbx1. In order to confirm that our mice model study would be representative of aggression hearing link, we conducted an evolutionary study that revealed that ASIP is negatively selected between mice and humans. When we analyzed RNA-seq for Asip ko mouse model we found that several genes controlling hearing were upregulated in the KO samples. We found these results reflected in the molecular pathway of melanocortin receptors 1 and 4, where their knocking out their negative agonist; Asip resulted in upregulating various hearing associated genes such as Fat2 among others.	./cache/cord-102729-b1q7gbd6.txt	./txt/cord-102729-b1q7gbd6.txt