id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-102763-tc1z0nm9	Zhang, Yuan	IgY antibodies against Ebola virus possess post-exposure protection and excellent thermostability	2020-05-21		.txt	text/plain	1764	104	53	Lethal dose of virus challenged mice were treated 2 or 24 h post-infection with different doses of anti-EBOV IgY. We developed a highly thermostable therapeutic antibody against EBOV based on chicken immunoglobulin Y (IgY). The newborn mice receiving passive transfer of IgY achieved complete protection against a lethal dose of virus challenge indicating that the anti-EBOV IgY provides a promising countermeasure to solve the current clinical application problems of Ebola antibody-based treatments in Africa. To obtain high titer EBOV NAbs, 5-month-old laying hens were vaccinated with five different 124 immunogens, including 10 3 or 10 4 TCID 50 VSVΔ G/EBOVGP, 100 μ g rEBOVGP, 100 μ g 125 pCAGGS/EBOVGP, 10 μg EBOV-VLP, and 10 11 virus particles (vp) Ad5/EBOVGP (Fig 2a) . Protective 546 monotherapy against lethal Ebola virus infection by a potently neutralizing antibody Protective 546 monotherapy against lethal Ebola virus infection by a potently neutralizing antibody	./cache/cord-102763-tc1z0nm9.txt	./txt/cord-102763-tc1z0nm9.txt