id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-102811-jlr4vb4u	Baumeister, Sebastian E	Physical activity and risk of Alzheimer’s disease: a two-sample Mendelian randomization study	2019-10-29		.txt	text/plain	2194	111	38	Several meta-analyses of observational studies suggested a protective effect of physical activity for cognitive decline and risk of dementia and AD [3] [4] [5] [6] [7] [8] [9] [10] . Mendelian randomization (MR) is a method that uses genetic variants as instrumental variables to uncover causal relationships in the presence of observational study bias such as unobserved confounding and reverse causation [15] . We selected eight SNPs associated with accelerometer-based physical activity (mean acceleration in milli-gravities) at a genome-wide significance level (P < 5 x 10 -8 ), using a PLINKclumping algorithm (r² threshold = 0.001 and window size = 10mB), from a genome-wide study of 91,084 UK Biobank participants [16] (Supplementary Table 1 ). Summary data for the association of SNPs for accelerometer-based physical activity with AD were obtained from a GWAS of 21,982 clinically-confirmed AD cases and 41,944 cognitively normal controls [17] . Physical activity can improve cognition in patients with Alzheimer's disease: a systematic review and meta-analysis of randomized controlled trials	./cache/cord-102811-jlr4vb4u.txt	./txt/cord-102811-jlr4vb4u.txt