id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-102886-oo7q05ml	Gomes, Fabio M.	“Proliferation of DBLOX Peroxidase-Expressing Oenocytes Maintains Innate Immune Memory in Primed Mosquitoes”	2020-09-10		.txt	text/plain	1963	116	45	title: "Proliferation of DBLOX Peroxidase-Expressing Oenocytes Maintains Innate Immune Memory in Primed Mosquitoes" Immune priming in Anopheles gambiae mosquitoes following infection with Plasmodium parasites is mediated by the systemic release of a hemocyte differentiation factor (HDF), a complex of lipoxin A4 bound to Evokin, a lipid carrier. We provide direct evidence that modifications mediated by the histone acetyltransferase AgTip60 (AGAP01539) are essential for sustained oenocyte proliferation, HDF synthesis and immune priming. We propose that oenocytes function as a population of "memory" cells that continuously release lipoxin to orchestrate and maintain a broad, systemic and long-lasting state of enhanced immune surveillance. We recently showed that two heme peroxidases, HPX7 and HPX8, are necessary for midgut PGE 2 synthesis and are essential to establish immune priming in response to Plasmodium infection (8) . These cells express high levels of DBLOX and their proliferation is essential for HDF synthesis and to maintain the priming response.	./cache/cord-102886-oo7q05ml.txt	./txt/cord-102886-oo7q05ml.txt