id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-102964-zh737cjk	Ferraro, Francesco	Modulation of endothelial organelle size as an antithrombotic strategy	2020-05-17		.txt	text/plain	5532	357	43	Out of 1280 human licensed drugs we found 58 compounds fitting our criteria, with a variety of mechanisms of action consistent suggesting a number of pathways that influence biogenesis of WPBs. A quantitative high-throughput microscopy-based workflow, dubbed highthroughput morphometry (HTM), allows rapid quantification of the size of tens to hundreds of thousands of WPBs within thousands of endothelial cells (Ferraro et al., 2014) . We have previously shown that treatment of endothelial cells with two statins, simvastatin and fluvastatin, induces WPB size shortening, resulting in reduced adhesive properties of the VWF released by activated endothelial cells (HUVEC), measured by the reduced size of platelet-decorated VWF strings and by the recruitment of VWF from a flowing plasma pool (Ferraro et al., 2016) . Further to the potential toxicity associated with administration of drugs at high concentrations, we note that in vitro combination of WPB-size reducing treatments, acting through different mechanisms, can display synergy in the abatement of plasma VWF recruitment to the endothelial surface (Supplemental Figure 1) .	./cache/cord-102964-zh737cjk.txt	./txt/cord-102964-zh737cjk.txt