id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-102977-yci9kq6x	Liu, Haiming	GHSR-1a is not Required for Ghrelin’s Anti-inflammatory and Fat-sparing Effects in Cancer Cachexia	2019-12-06		.txt	text/plain	4891	291	59	This study characterizes the pathways involved in AT atrophy in the Lewis Lung Carcinoma (LLC)-induced cachexia model and those mediating the effects of ghrelin in Ghsr+/+ and Ghsr−/− mice. GHSR-1a is not expressed in adipocytes (Sun, Garcia et 243 al., 2007) but is present in macrophages (Ma, Lin et al., 2013) and our findings are consistent with a 244 previous report showing that old, non-tumor-bearing Ghsr -/mice have reduced macrophage 245 infiltration, a shift on macrophage differentiation towards a more anti-inflammatory phenotype, and 246 decreased inflammation in adipose tissue (Lin, Lee et al., 2016) . In this study, we did 278 not see a significant effect of ghrelin on preventing LLC-induced fat browning, BAT thermogenesis, 279 increased REE or decreased physical activity in the setting of CACS despite the fact that ghrelin 280 prevented fat and weight loss and anorexia.	./cache/cord-102977-yci9kq6x.txt	./txt/cord-102977-yci9kq6x.txt